Linan Zhang, Yilin Liu, Gangjian Luo, Chaojin Chen, Chaoxun Dou, Jingyi Du, Hanbin Xie, Yu Guan, Jing Yang, Zhendong Ding, Ziyan Huang, Yongming Chen, Ziqing Hei, Zhen Zhang, Weifeng Yao
Perioperative neurocognitive disorder (PND) is a common complication in surgical patients. While many interventions to prevent PND have been studied, the availability of treatment methods is limited. Thus, it is crucial to delve into the mechanisms of PND, pinpoint therapeutic targets, and develop effective treatment approaches. In this study, reduced dorsal tenia tecta (DTT) neuronal activity was found to be associated with tibial fracture surgery-induced PND, indicating that a neuronal excitation-inhibition (E-I) imbalance could contribute to PND...
April 17, 2024: ACS Nano