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https://www.readbyqxmd.com/read/29629545/diagnosis-of-early-stage-idiopathic-parkinson-s-disease-using-high-resolution-quantitative-susceptibility-mapping-combined-with-histogram-analysis-in-the-substantia-nigra-at-3-t
#1
Eung Yeop Kim, Young Hee Sung, Hyeong Geol Shin, Young Noh, Yoonho Nam, Jongho Lee
BACKGROUND AND PURPOSE: To test whether nigrosome-1 imaging using high-resolution quantitative susceptibility mapping (QSM) combined with histogram analysis can improve the diagnostic accuracy in early-stage idiopathic Parkinson's disease (IPD) patients. METHODS: Three-dimensional multiecho gradient-recalled echo images (0.5×0.5×1.0 mm³) were obtained at 3 T for QSM in 38 patients with IPD and 25 healthy subjects. To segment the substantia nigra (SN), regions of interest (ROIs) were semiautomatically drawn at the location below the red nucleus, and the normal-appearing nigrosome-1 was determined by manual correction...
January 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29530959/nigrosome-1-absence-in-de-novo-parkinson-disease
#2
Matthew Brodsky, David Lahna, Jeffrey Pollock, David Pettersson, John Grinstead, William Rooney
No abstract text is available yet for this article.
March 13, 2018: Neurology
https://www.readbyqxmd.com/read/29498540/quantifying-changes-in-nigrosomes-using-quantitative-susceptibility-mapping-and-neuromelanin-imaging-for-the-diagnosis-of-early-stage-parkinson-s-disease
#3
Hiroto Takahashi, Yoshiyuki Watanabe, Hisashi Tanaka, Masahito Mihara, Hideki Mochizuki, Tian Liu, Yi Wang, Noriyuki Tomiyama
OBJECTIVE: To quantify nigral changes with a focus on their spatial variation within the substantia nigra pars compacta (SNpc) for diagnosing early-stage Parkinson's disease (PD). METHODS: The study participants were 18 patients with early-stage PD (PD group) and 18 healthy controls (HC group) who underwent quantitative susceptibility mapping (QSM) and neuromelanin imaging. The QSM and neuromelanin values in each whole SNpc containing the entire nigrosome and dorsolateral SNpc containing nigrosome 1 were calculated...
March 2, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29247084/protocol-of-a-single-group-prospective-observational-study-on-the-diagnostic-value-of-3t-susceptibility-weighted-mri-of-nigrosome-1-in-patients-with-parkinsonian-symptoms-the-n3-i-pd-study-nigrosomal-i-ron-i-maging-i-n-parkinson-s-disease
#4
Stefan T Schwarz, Yue Xing, Saadnah Naidu, Jim Birchall, Rob Skelly, Alan Perkins, Jonathan Evans, Gill Sare, Antonio Martin-Bastida, Nin Bajaj, Penny Gowland, Paola Piccini, Dorothee P Auer
INTRODUCTION: Parkinson's disease (PD) is the most common movement disorder in the elderly and is characterised clinically by bradykinesia, tremor and rigidity. Diagnosing Parkinson's can be difficult especially in the early stages. High-resolution nigrosome MRI offers promising diagnostic accuracy of patients with established clinical symptoms; however, it is unclear whether this may help to establish the diagnosis in the early stages of PD, when there is diagnostic uncertainty. In this scenario, a single photon emission CT scan using a radioactive dopamine transporter ligand can help to establish the diagnosis, or clinical follow-up may eventually clarify the diagnosis...
December 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29073886/ultra-high-field-swi-of-the-substantia-nigra-at-7t-reliability-and-consistency-of-the-swallow-tail-sign
#5
Manuel A Schmidt, Tobias Engelhorn, Franz Marxreiter, Juergen Winkler, Stefan Lang, Stephan Kloska, Philipp Goelitz, Arnd Doerfler
BACKGROUND: The loss of the swallow-tail sign of the substantia nigra has been proposed for diagnosis of Parkinson's disease. Aim was to evaluate, if the sign occurs consistently in healthy subjects and if it can be reliably detected with high-resolution 7T susceptibility weighted imaging (SWI). METHODS: Thirteen healthy adults received SWI at 7T. 3 neuroradiologists, who were blinded to patients' diagnosis, independently classified subjects regarding the swallow-tail sign to be present or absent...
October 26, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29064601/differential-involvement-of-nigral-subregions-in-idiopathic-parkinson-s-disease
#6
Young Hee Sung, Jongho Lee, Yoonho Nam, Hyeong-Geol Shin, Young Noh, Dong Hoon Shin, Eung Yeop Kim
In this study, the prevalence of abnormality in putative nigrosome 1 and nigrosome 4 (N1 and N4, respectively) was investigated in early versus late-stage idiopathic Parkinson's disease (IPD) patients. A total of 128 IPD patients (early stage[n = 89]; late stage[n = 39]) and 15 healthy subjects were scanned for high-resolution (0.5 × 0.5 × 1.0 mm3 ) multiecho gradient-recalled echo MRI and dopamine transporter PET imaging. The MRI data were processed for susceptibility map-weighted imaging (SMWI) to improve a contrast-to-noise ratio, and the images were resliced at 0...
January 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29016618/nigrosome-1-visibility-at-susceptibility-weighted-7t-mri-a-dependable-diagnostic-marker-for-parkinson-s-disease-or-merely-an-inconsistent-age-dependent-imaging-finding
#7
Carolin Gramsch, Iris Reuter, Oliver Kraff, Harald H Quick, Christian Tanislav, Florian Roessler, Cornelius Deuschl, Michael Forsting, Marc Schlamann
BACKGROUND: Visualisation of nigrosome 1, a substructure of the healthy substantia nigra, was restricted in susceptibility weighted MR imaging in almost all patients with Parkinson's disease studied so far. The purpose of this study was to determine the degree of visibility of this substructure in subjects without Parkinson's disease and to examine the potential link between increasing brain iron accumulation with age and its detectability. METHODS: In 46 subjects (21 women, 25 men; 19 to 75 y; mean age: 44...
2017: PloS One
https://www.readbyqxmd.com/read/28705819/mri-of-the-swallow-tail-sign-a-useful-marker-in-the-diagnosis-of-lewy-body-dementia
#8
S Shams, D Fällmar, S Schwarz, L-O Wahlund, D van Westen, O Hansson, E-M Larsson, S Haller
BACKGROUND AND PURPOSE: There are, to date, no MR imaging diagnostic markers for Lewy body dementia. Nigrosome 1, containing dopaminergic cells, in the substantia nigra pars compacta is hyperintense on SWI and has been called the swallow tail sign, disappearing with Parkinson disease. We aimed to study the swallow tail sign and its clinical applicability in Lewy body dementia and hypothesized that the sign would be likewise applicable in Lewy body dementia. MATERIALS AND METHODS: This was a retrospective cross-sectional multicenter study including 97 patients (mean age, 65 ± 10 years; 46% women), consisting of the following: controls (n = 21) and those with Lewy body dementia (n = 19), Alzheimer disease (n = 20), frontotemporal lobe dementia (n = 20), and mild cognitive impairment (n = 17)...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28331948/erratum-to-diagnostic-imaging-of-dementia-with-lewy-bodies-by-susceptibility-weighted-imaging-of-nigrosomes-versus-striatal-dopamine-transporter-single-photon-emission-computed-tomography-a-retrospective-observational-study
#9
Koji Kamagata, Tomoya Nakatsuka, Ryuji Sakakibara, Yohei Tsuyusaki, Tomohiro Takamura, Kanako Sato, Michimasa Suzuki, Masaaki Hori, Kanako K Kumamaru, Tsutomu Inaoka, Shigeki Aoki, Hitoshi Terada
No abstract text is available yet for this article.
April 2017: Neuroradiology
https://www.readbyqxmd.com/read/28035426/diagnostic-imaging-of-dementia-with-lewy-bodies-by-susceptibility-weighted-imaging-of-nigrosomes-versus-striatal-dopamine-transporter-single-photon-emission-computed-tomography-a-retrospective-observational-study
#10
Koji Kamagata, Tomoya Nakatsuka, Ryuji Sakakibara, Yohei Tsuyusaki, Tomohiro Takamura, Kanako Sato, Michimasa Suzuki, Masaaki Hori, Kanako K Kumamaru, Tsutomu Inaoka, Shigeki Aoki, Hitoshi Terada
INTRODUCTION: The characteristics of dementia with Lewy bodies (DLB), Alzheimer's disease (AD) and amnestic mild cognitive impairment (a-MCI) overlap but require different treatments; therefore, it is important to differentiate these pathologies. Assessment of dopamine uptake in the striatum using dopamine transporter (DaT) single-photon emission computed tomography (SPECT) is the gold standard for diagnosing DLB; however, this modality is expensive, time consuming and involves radiation exposure...
January 2017: Neuroradiology
https://www.readbyqxmd.com/read/27981030/9-4-t-mr-microscopy-of-the-substantia-nigra-with-pathological-validation-in-controls-and-disease
#11
L A Massey, M A Miranda, O Al-Helli, H G Parkes, J S Thornton, P-W So, M J White, L Mancini, C Strand, J Holton, A J Lees, T Revesz, T A Yousry
BACKGROUND: The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures. We sought to define the anatomy of the SN using high field spin-echo MRI of pathological material in which we could study the anatomy in detail to corroborate our MRI findings in controls and Parkinson's disease and progressive supranuclear palsy. METHODS: 23 brains were selected from the Queen Square Brain Bank (10 controls, 8 progressive supranuclear palsy, 5 Parkinson's disease) and imaged using high field 9...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27859983/imaging-of-nigrosome-1-in-substantia-nigra-at-3t-using-multiecho-susceptibility-map-weighted-imaging-smwi
#12
Yoonho Nam, Sung-Min Gho, Dong-Hyun Kim, Eung Yeop Kim, Jongho Lee
PURPOSE: To enhance the visibility of nigrosome 1 in substantia nigra, which has recently been suggested as an imaging biomarker for Parkinson's disease (PD) at 3T magnetic resonance imaging (MRI). MATERIALS AND METHODS: The substantia nigra structure was visualized at 3T MRI using multiecho susceptibility map-weighted imaging (SMWI) in 15 healthy volunteers and 6 patients with Parkinson's disease (PD). The visibility of nigrosome 1 was further enhanced by acquiring data in an oblique-coronal imaging plane at a high spatial resolution (0...
November 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27812347/t2-imaging-changes-in-the-nigrosome-1-relate-to-clinical-measures-of-parkinson-s-disease
#13
Katherine A Fu, Romil Nathan, Ivo D Dinov, Junning Li, Arthur W Toga
BACKGROUND: The nigrosome-1 region of the substantia nigra (SN) undergoes the greatest and earliest dopaminergic neuron loss in Parkinson's disease (PD). As T2-weighted magnetic resonance imaging (MRI) scans are often collected with routine clinical MRI protocols, this investigation aims to determine whether T2-imaging changes in the nigrosome-1 are related to clinical measures of PD and to assess their potential as a more clinically accessible biomarker for PD. METHODS: Voxel intensity ratios were calculated for T2-weighted MRI scans from 47 subjects from the Parkinson's Progression Markers Initiative database...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27559425/nigrosome-1-on-susceptibility-weighted-imaging-to-differentiate-parkinson-s-disease-from-atypical-parkinsonism-an-in-vivo-and-ex-vivo-pilot-study
#14
Frederick J A Meijer, Stefan C Steens, Anouke van Rumund, Anne-Marie van Cappellen van Walsum, Benno Küsters, Rianne A J Esselink, Marcel M Verbeek, Bastiaan R Bloem, Bożena Goraj
BACKGROUND: Previous case-control studies have suggested that the absence of a swallow-tail appearance in the substantia nigra on high-resolution SWI, representing nigrosome-1, has high accuracy to identify Parkinson's disease (PD). The first goal of our study was to evaluate nigrosome-1 ex vivo using optimized high-resolution susceptibility sensitive MRI. Our second goal was to evaluate its diagnostic value in vivo using a clinical 3T SWI sequence to differentiate between PD and atypical parkinsonism (AP) in a cohort of patients with early-stage parkinsonism...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27489952/correlation-of-3d-flair-and-dopamine-transporter-imaging-in-patients-with-parkinsonism
#15
Se Won Oh, Na-Young Shin, Jae Jung Lee, Seung-Koo Lee, Phil Hyu Lee, Soo Mee Lim, Jin Woo Kim
OBJECTIVE: The purpose of this study is to evaluate direct in vivo visualization of nigrosome-1 in substantia nigra (SN) with 3D FLAIR imaging and its diagnostic value in predicting the intactness of presynaptic dopaminergic function of the nigrostriatal pathway. MATERIALS AND METHODS: Forty-five patients showing parkinsonism who underwent both 3D FLAIR and dopamine transporter (DAT) imaging were recruited. In total, 90 SNs were reviewed on axial 3D FLAIR images...
November 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/26951846/loss-of-substantia-nigra-hyperintensity-on-7-tesla-mri-of-parkinson-s-disease-multiple-system-atrophy-and-progressive-supranuclear-palsy
#16
Jong-Min Kim, Hye-Jin Jeong, Yun Jung Bae, Sung-Yeon Park, Eunhee Kim, Seo Young Kang, Eung Seok Oh, Kyeong Joon Kim, Beomseok Jeon, Sang Eun Kim, Zang-Hee Cho, Young-Bo Kim
BACKGROUND: Seven Tesla (7T) MRI can visualize anatomical alterations occurring in a hyperintense structure of the substantia nigra in Parkinson's disease (PD). OBJECTIVE: We investigated whether 7T MRI can detect the loss of substantia nigra hyperintensity in patients with PD, multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). METHODS: Using 7T MRI, we evaluated 26 healthy subjects, 30 patients with PD, 7 patients with MSA, and 3 patients with PSP...
May 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/26698258/visualization-of-nigrosomes-1-in-3t-mr-susceptibility-weighted-imaging-and-its-absence-in-diagnosing-parkinson-s-disease
#17
P Gao, P-Y Zhou, G Li, G-B Zhang, P-Q Wang, J-Z Liu, F Xu, F Yang, X-X Wu
OBJECTIVE: To assess the imaging features of nigrosomes-1 in the substantia nigra through 3T MR susceptibility weighted imaging (SWI) and its disease-specific changes for the diagnosis of Parkinson's disease (PD). PATIENTS AND METHODS: A total of 116 subjects were included in this study and allocated into 3 groups: 54 patients diagnosed with PD were assigned to the PD group, 51 age- and sex-matched volunteers without PD served as the control N-PD group, and 11 clinically suspected PD patients were allocated to the undiagnosed (UD) group...
December 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26690908/drug-induced-parkinsonism-versus-idiopathic-parkinson-disease-utility-of-nigrosome-1-with-3-t-imaging
#18
Young Hee Sung, Young Noh, Jongho Lee, Eung Yeop Kim
Purpose To explore the utility of nigrosome 1 with 3-T magnetic resonance (MR) imaging to differentiate idiopathic Parkinson disease (IPD) from drug-induced parkinsonism (DIP). Materials and Methods The institutional review board approved this study, and participants gave informed consent. This study enrolled patients with DIP (n = 20) and IPD (n = 29) who underwent N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl)nortropane ((18)F-FP-CIT) positron emission tomography (PET) and healthy participants (n = 20)...
June 2016: Radiology
https://www.readbyqxmd.com/read/26294646/nigrosome-1-detection-at-3t-mri-for-the-diagnosis-of-early-stage-idiopathic-parkinson-disease-assessment-of-diagnostic-accuracy-and-agreement-on-imaging-asymmetry-and-clinical-laterality
#19
Y Noh, Y H Sung, J Lee, E Y Kim
BACKGROUND AND PURPOSE: In the early stages of idiopathic Parkinson disease, motor symptoms are usually asymmetric. We aimed to assess the feasibility of nigrosome 1 detection at 3T MR imaging to analyze the agreement of its asymmetry and clinical laterality. MATERIALS AND METHODS: High-resolution 3D multiecho imaging was performed at 3T MR imaging in 13 healthy subjects and 24 patients with idiopathic Parkinson disease confirmed by N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane ((18)F-FP-CIT) PET...
November 2015: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/25645462/loss-of-angiotensin-ii-receptor-expression-in-dopamine-neurons-in-parkinson-s-disease-correlates-with-pathological-progression-and-is-accompanied-by-increases-in-nox4-and-8-oh-guanosine-related-nucleic-acid-oxidation-and-caspase-3-activation
#20
W Michael Zawada, Robert E Mrak, JoAnn Biedermann, Quinton D Palmer, Stephen M Gentleman, Orwa Aboud, W Sue T Griffin
BACKGROUND: In rodent models of Parkinson's disease (PD), dopamine neuron loss is accompanied by increased expression of angiotensin II (AngII), its type 1 receptor (AT1), and NADPH oxidase (Nox) in the nigral dopamine neurons and microglia. AT1 blockers (ARBs) stymie such oxidative damage and neuron loss. Whether changes in the AngII/AT1/Nox4 axis contribute to Parkinson neuropathogenesis is unknown. Here, we studied the distribution of AT1 and Nox4 in dopamine neurons in two nigral subregions: the less affected calbindin-rich matrix and the first-affected calbindin-poor nigrosome 1 of three patients, who were clinically asymptomatic, but had nigral dopamine cell loss and Braak stages consistent with a neuropathological diagnosis of PD (prePD)...
February 3, 2015: Acta Neuropathologica Communications
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