keyword
https://read.qxmd.com/read/38252367/complement-system-deficiencies-in-elite-athletes
#21
JOURNAL ARTICLE
Libor Vítek, Jana Woronyczova, Veronika Hanzikova, Helena Posová
BACKGROUND: Although regular physical activity improves immune competency and reduces the prevalence of inflammatory diseases, strenuous training in elite athletes is associated with an increased susceptibility to infectious complications. Therefore, the objective of our study was to assess the routinely examined parameters of the complement system in elite athletes. The study was carried out in a cohort of elite athletes (n = 134) and healthy control subjects (n = 110)...
January 22, 2024: Sports Medicine—Open
https://read.qxmd.com/read/38244136/mannose-specific-plant-and-microbial-lectins-as-antiviral-agents-a-review
#22
REVIEW
Ankita Gupta, Kusum Yadav, Anurag Yadav, Rumana Ahmad, Aditi Srivastava, Dileep Kumar, Mohammad Amir Khan, U N Dwivedi
Lectins are non-immunological carbohydrate-binding proteins classified on the basis of their structure, origin, and sugar specificity. The binding specificity of such proteins with the surface glycan moiety determines their activity and clinical applications. Thus, lectins hold great potential as diagnostic and drug discovery agents and as novel biopharmaceutical products. In recent years, significant advancements have been made in understanding plant and microbial lectins as therapeutic agents against various viral diseases...
January 20, 2024: Glycoconjugate Journal
https://read.qxmd.com/read/38224220/aunps-cnc-nanocomposite-with-a-dual-dispersion-effect-for-ldi-tof-ms-analysis-of-intact-proteins-in-nsclc-serum-exosomes
#23
JOURNAL ARTICLE
Liang Shan, Yongxia Qiao, Lifang Ma, Xiao Zhang, Changqiang Chen, Xin Xu, Dan Li, Shiyu Qiu, Xiangfei Xue, Yongchun Yu, Yinlong Guo, Kun Qian, Jiayi Wang
Detecting exosomal markers using laser desorption/ionization time-of-flight mass spectrometry (LDI-TOF MS) is a novel approach for examining liquid biopsies of non-small cell lung cancer (NSCLC) samples. However, LDI-TOF MS is limited by low sensitivity and poor reproducibility when analyzing intact proteins directly. In this report, gold nanoparticles/cellulose nanocrystals (AuNPs/CNC) is introduced as the matrix for direct analysis of intact proteins in NSCLC serum exosomes. AuNPs/CNC with "dual dispersion" effects dispersed and stabilized AuNPs and improved ion inhibition effects caused by protein aggregation...
January 15, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38187242/high-production-mbl2-polymorphisms-protect-against-covid-19-complications-in-critically-ill-patients-a-retrospective-cohort-study
#24
JOURNAL ARTICLE
Lorena Viana de Andrade, Mirela Vanessa de Souza Sá, Beatriz Vasconcelos, Luydson Richardson Silva Vasconcelos, Ricardo Khouri, Carlos Dornels Freire de Souza, Anderson da Costa Armstrong, Rodrigo Feliciano do Carmo
Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association of MBL2 polymorphisms with the risk of hospitalization and clinical worsening in patients with COVID-19. A total of 550 patients with COVID-19 were included (94 non-hospitalized and 456 hospitalized). Polymorphisms in MBL2 exon 1 (codons 52, 54 and 57) and promoter region (-550, -221, and +4) were determined by real-time PCR...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38182041/recognition-of-highly-branched-n-glycans-of-the-porcine-whipworm-by-the-immune-system
#25
JOURNAL ARTICLE
Barbara Eckmair, Chao Gao, Akul Y Mehta, Zuzanna Dutkiewicz, Jorick Vanbeselaere, Richard D Cummings, Katharina Paschinger, Iain B H Wilson
Glycans are key to host-pathogen interactions, whereby recognition by the host and immunomodulation by the pathogen can be mediated by carbohydrate binding proteins, such as lectins of the innate immune system, and their glycoconjugate ligands. Previous studies have shown that excretory-secretory products of the porcine nematode parasite Trichuris suis exert immunomodulatory effects in a glycan-dependent manner. To better understand the mechanisms of these interactions, we prepared N-glycans from T. suis and both analyzed their structures and used them to generate a natural glycan microarray...
January 3, 2024: Molecular & Cellular Proteomics: MCP
https://read.qxmd.com/read/38170734/fungal-chitin-binding-glycoprotein-induces-dectin-2-mediated-allergic-airway-inflammation-synergistically-with-chitin
#26
JOURNAL ARTICLE
Yasunori Muraosa, Yutaro Hino, Shogo Takatsuka, Akira Watanabe, Emiko Sakaida, Shinobu Saijo, Yoshitsugu Miyazaki, Sho Yamasaki, Katsuhiko Kamei
Although chitin in fungal cell walls is associated with allergic airway inflammation, the precise mechanism underlying this association has yet to be elucidated. Here, we investigated the involvement of fungal chitin-binding protein and chitin in allergic airway inflammation. Recombinant Aspergillus fumigatus LdpA (rLdpA) expressed in Pichia pastoris was shown to be an O-linked glycoprotein containing terminal α-mannose residues recognized by the host C-type lectin receptor, Dectin-2. Chitin particles were shown to induce acute neutrophilic airway inflammation mediated release of interleukin-1α (IL-1α) associated with cell death...
January 2024: PLoS Pathogens
https://read.qxmd.com/read/38167099/association-of-mbl2-gene-polymorphisms-and-mbl-levels-with-dilated-cardiomyopathy-in-a-chinese-han-population
#27
JOURNAL ARTICLE
Yujie Mao, Hong Wei, Yugang Gong, Lei Peng, Yu Chen
BACKGROUND: It has been reported that Mannose-binding lectin 2 (MBL2) gene polymorphisms and expression levels are related to dilated cardiomyopathy (DCM). This study aimed to investigate the potential association between MBL2 gene polymorphisms and the pathogenesis of DCM. METHODS: Five single nucleotide polymorphisms (SNPs) of the MBL2 gene were genotyped in 440 DCM patients and 532 controls in Southwest China. A luciferase reporter assay was used to detect the transcriptional activity the different genotypes...
January 2, 2024: BMC Medical Genomics
https://read.qxmd.com/read/38163494/pvmr1-a-novel-c-type-lectin-plays-a-crucial-role-in-the-antibacterial-immune-response-of-pacific-white-shrimp-penaeus-vannamei
#28
JOURNAL ARTICLE
Weiran Huo, Lu Qin, Wanwan Guo, Xiaowen Zhang, Qiyan Du, Xiaohua Xia
C-type lectins (CTLs) are important immune molecules in innate immune, which participate in non-self recognition and clearance of pathogens. Here, a new CTL with two distinct C-type lectin domains (CTLDs) from Pacific white shrimp Penaeus vannamei, designated as PvMR1 was identified. The obtained PvMR1 coding sequence (CDS) was 1044 bp long encoding a protein with 347 amino acids. PvMR1 had two CTLD, a conserved mannose-specific EPN motif and a galactose-specific QPD motif, clustering into the same branch as the crustacean CTLs...
December 30, 2023: Fish & Shellfish Immunology
https://read.qxmd.com/read/38112943/serum-proteomic-profiling-reveals-potential-inflammatory-biomarkers-in-long-covid-patients-a-comparative-analysis-with-healthy-controls
#29
JOURNAL ARTICLE
M C Medori, K Dhuli, S Tezzele, C Micheletti, P E Maltese, S Cecchin, G Bonetti, F Fioretti, A Calzoni, A Praderio, M G De Angelis, G Arabia, K Donato, L Lorusso, P Manganotti, E Capelli, S Cristoni, S Nodari, M Bertelli
OBJECTIVE: The highly transmissible severe acute respiratory syndrome-Coronavirus-2 was responsible for the 2020 COVID-19 pandemic. COVID-19 mostly affects the respiratory system; however, this infection also affects several other organs. In addition, the sequelae of this disease affect patients for several months after recovery, resulting in long-COVID syndrome. PATIENTS AND METHODS: In order to characterize the differences between healthy control individuals and long-COVID patients, proteomic profiling of the serum of both groups was performed by mass spectrometry...
December 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38092094/identification-and-characterization-of-an-l-type-lectin-from-obscure-puffer-takifugu-obscurus-in-response-to-bacterial-infection
#30
JOURNAL ARTICLE
Fu-Hui Jiang, Ying Huang, Xin-Yue Yu, Li-Fan Cui, Yan Shi, Xiao-Rui Song, Zhe Zhao
L-type lectins (LTLs) contain a carbohydrate recognition domain homologous to leguminous lectins, and have functions in selective protein trafficking, sorting and targeting in the secretory pathway of animals. In this study, a novel LTL, designated as ToERGIC-53, was cloned and identified from obscure puffer Takifugu obscurus. The open reading frame of ToERGIC-53 contained 1554 nucleotides encoding 517 amino acid residues. The deduced ToERGIC-53 protein consisted of a signal peptide, a leguminous lectin domain (LTLD), a coiled-coil region, and a transmembrane region...
December 11, 2023: Fish & Shellfish Immunology
https://read.qxmd.com/read/38073222/pre-treatment-inflammatory-and-immune-system-parameters-predicting-cervical-cancer-metastasis
#31
JOURNAL ARTICLE
Mirah Avisha, Nugraha Utama Pelupessy, Abdul Rahman, Syahrul Rauf, Nur Rakhmah, Firdaus Hamid
OBJECTIVE: This study aimed to evaluate the relationship between mannose-binding lectin-associated serine protease-2 as an immune system parameter and neutrophil lymphocyte ratio (NLR) as an inflammatory parameter to predict cervical cancer metastasis. MATERIALS AND METHODS: This cross-sectional study included 70 patients diagnosed with cervical cancer between January 2022 and February 2023 at Dr. Wahidin Sudirohusodo Hospital, Hasanuddin University Hospital, and Ibnu Sina Hospital, Makassar, Indonesia...
December 8, 2023: Turkish Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38050344/regulation-of-the-innate-immune-response-and-gut-microbiome-by-p53
#32
JOURNAL ARTICLE
Amy Hui Ping Khor, Tomoyuki Koguchi, Hao Liu, Masanori Kakuta, Daisuke Matsubara, Ruimeng Wen, Yoji Sagiya, Seiya Imoto, Hidewaki Nakagawa, Koichi Matsuda, Chizu Tanikawa
p53 is a key tumor suppressor mutated in half of human cancers. In recent years, p53 was shown to regulate a wide variety of functions. From the transcriptome analysis of 24 tissues of irradiated mice, we identified 553 genes markedly induced by p53. Gene Ontology (GO) enrichment analysis found that the most associated biological process was innate immunity. 16S rRNA-seq analysis revealed that Akkermansia, which has anti-inflammatory properties and is involved in the regulation of intestinal barrier integrity, was decreased in p53-knockout (p53-/- ) mice after radiation...
December 4, 2023: Cancer Science
https://read.qxmd.com/read/38013973/c1-esterase-inhibitor-mediated-immunosuppression-in-covid-19-friend-or-foe
#33
REVIEW
Melissa A Hausburg, Jason S Williams, Kaysie L Banton, Charles W Mains, Michael Roshon, David Bar-Or
From asymptomatic to severe, SARS-CoV-2, causative agent of COVID-19, elicits varying disease severities. Moreover, understanding innate and adaptive immune responses to SARS-CoV-2 is imperative since variants such as Omicron negatively impact adaptive antibody neutralization. Severe COVID-19 is, in part, associated with aberrant activation of complement and Factor XII (FXIIa), initiator of contact system activation. Paradoxically, a protein that inhibits the three known pathways of complement activation and FXIIa, C1 esterase inhibitor (C1-INH), is increased in COVID-19 patient plasma and is associated with disease severity...
December 2022: Clin Immunol Commun
https://read.qxmd.com/read/38002835/the-role-of-mannose-binding-lectin-and-inflammatory-markers-in-establishing-the-course-and-prognosis-of-community-acquired-pneumonia-in-children
#34
JOURNAL ARTICLE
Roxana Taraș, Beatrice Mahler, Mihaela Bălgrădean, Diana Derewicz, Miruna Ioana Lazăr, Ruxandra Vidlescu, Florian Berghea
BACKGROUND: Community-acquired pneumonia (CAP) is one of the most significant childhood diseases worldwide and a leading infectious cause of death in children. This study aimed to evaluate the prognostic value of the inflammatory markers-C-reactive protein (CRP) and procalcitonin (PCT)-and the polymorphic glycoprotein mannose-binding lectin (MBL), deficiency of which is associated with severe infections, in the determination of the optimal type and timing of therapeutic intervention for CAP in childhood...
October 27, 2023: Children
https://read.qxmd.com/read/37979136/fluorinated-man-9-as-a-high-mannose-mimetic-to-unravel-its-recognition-by-dc-sign-using-nmr
#35
JOURNAL ARTICLE
Adrián Silva-Díaz, Jonathan Ramírez-Cárdenas, Juan C Muñoz-García, M Carmen de la Fuente, Michel Thépaut, Franck Fieschi, Javier Ramos-Soriano, Jesús Angulo, Javier Rojo
Lectins are capable of reading out the structural information contained in carbohydrates through specific recognition processes. Determining the binding epitope of the sugar is fundamental to understanding this recognition event. Nuclear magnetic resonance (NMR) is a powerful tool to obtain this structural information in solution; however, when the sugar involved is a complex oligosaccharide, such as high mannose, the signal overlap found in the NMR spectra precludes an accurate analysis of the interaction...
November 18, 2023: Journal of the American Chemical Society
https://read.qxmd.com/read/37972111/the-pseudomonas-aeruginosa-lectin-lecb-modulates-intracellular-reactive-oxygen-species-production-in-human-neutrophils
#36
JOURNAL ARTICLE
Felix P Sanchez Klose, Agnes Dahlstrand Rudin, Linda Bergqvist, Julia M Scheffler, Katarina Jönsson, Ulrika Islander, Anna Karlsson-Bengtsson, Johan Bylund, Vignesh Venkatakrishnan
Pseudomonas aeruginosa is a gram-negative bacterium and an opportunistic pathogen ubiquitously present throughout nature. LecB, a fucose- and mannose-binding lectin, is a prominent virulence factors of P. aeruginosa, which can be expressed on the bacterial surface but also be secreted. However, the LecB interaction with human immune cells remain to be characterized. Neutrophils comprise the first line of defense against infections and their production of reactive oxygen species (ROS) and release of extracellular traps (NETs) are critical antimicrobial mechanisms...
November 16, 2023: European Journal of Immunology
https://read.qxmd.com/read/37958949/structural-analysis-and-characterization-of-an-antiproliferative-lectin-from-canavalia-villosa-seeds
#37
JOURNAL ARTICLE
Claudia F Lossio, Vinicius J S Osterne, Vanir R Pinto-Junior, Simin Chen, Messias V Oliveira, Joost Verduijn, Isabel Verbeke, Sonia Serna, Niels C Reichardt, Andre Skirtach, Benildo S Cavada, Els J M Van Damme, Kyria S Nascimento
Cells use glycans to encode information that modulates processes ranging from cell-cell recognition to programmed cell death. This information is encoded within a glycocode, and its decoding is performed by carbohydrate-binding proteins. Among these, lectins stand out due to their specific and reversible interaction with carbohydrates. Changes in glycosylation patterns are observed in several pathologies, including cancer, where abnormal glycans are found on the surfaces of affected tissues. Given the importance of the bioprospection of promising biomolecules, the current work aimed to determine the structural properties and anticancer potential of the mannose-specific lectin from seeds of Canavalia villosa (Cvill)...
November 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37944682/molecular-characterization-and-functional-analysis-of-galectin-1-from-silver-pomfret-pampus-argenteus
#38
JOURNAL ARTICLE
Suyang Chen, Tingting Gao, Xionglin Li, Kejing Huang, Lu Yuan, Suming Zhou, Jianhu Jiang, Yajun Wang, Jiasong Xie
Galectins, as members of lectin families, exhibit a high affinity for β-galactosides and play diverse roles in biological processes. They function as pattern recognition receptors (PRRs) with important roles in immune defense. In this study, galectin-1, designated as SpGal-1, was identified and characterized from silver pomfret (Pampus argenteus). The SpGal-1 comprises an open reading frame (ORF) spanning 396 base pairs (bp) and encodes a deduced amino acid (aa) sequence containing a single carbohydrate recognition domain (CRD)...
November 7, 2023: Fish & Shellfish Immunology
https://read.qxmd.com/read/37915610/elevated-high-mannose-n-glycans-hamper-endometrial-decidualization
#39
JOURNAL ARTICLE
Siyi Chen, Aihui Zhang, Na Li, Hongpan Wu, Yaqi Li, Shuai Liu, Qiu Yan
Decidualization of endometrial stromal cells is a hallmark of endometrial receptivity for embryo implantation, and dysfunctional decidualization is associated with pregnancy failure. Protein glycosylation is an important posttranslational modification that affects the structure and function of glycoproteins. Our results showed that high-mannose epitopes were elevated in the decidual tissues of miscarriage patients compared with early pregnant women by Lectin microarray. Furthermore, the level of mannosyl-oligosaccharide α-1,2 mannosidase IA (MAN1A1), a key enzyme for high-mannose glycan biosynthesis, was decreased in the decidual tissues of miscarriage patients...
November 17, 2023: IScience
https://read.qxmd.com/read/37896833/human-mannose-receptor-1-attenuates-hiv-1-infectivity-in-a-virus-isolate-specific-manner
#40
JOURNAL ARTICLE
Hideki Saito, Sayaka Sukegawa, Sandra Kao, Klaus Strebel
Human mannose receptor 1 (hMRC1) is a transmembrane glycoprotein that belongs to the C-type lectin family and is expressed on the surface of most tissue macrophages. hMRC1 contributes to the binding and transmission of HIV-1 and is involved in the endocytic uptake of HIV-1 for subsequent antigen presentation. We previously reported that hMRC1 functions as an antiviral factor by inhibiting virus release through a BST-2-like mechanism. The inhibition of virus release was not virus isolate-specific and, surprisingly, was not Env-dependent...
October 6, 2023: Viruses
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