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Mannose binding lectin

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https://www.readbyqxmd.com/read/28322582/man%C3%AE-1-2man-binding-anti-hiv-lectins-enhance-the-exposure-of-v2i-and-v3-crown-neutralization-epitopes-on-the-v1v2-and-v3-hypervariable-loops-of-hiv-1-envelope
#1
Muzafar Jan, Chitra Upadhyay, Aman Sharma, Caterina E Hioe, Sunil K Arora
This study aimed to explore the contribution of high mannose glycans in the masking of conserved GPG and LDI/V containing V3 crown and V2i epitopes on the hypervariable loops of most exposed distal surface of HIV-1 Env. Using lectins specific to Manα1-2Man residue containing Man6-9GlcNAc2 glycans extensively decorating HIV-1 Env, we found that Manα1-2Man binding lectins enhance the exposure of these partially and transiently exposed epitopes and consequentially increase the neutralization strength of these antibodies...
March 21, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28298186/association-of-mannose-binding-lectin-gene-polymorphisms-with-the-development-of-pulmonary-tuberculosis-in-china
#2
Yan-Ling Guo, Yang Liu, Wu-Juan Ban, Qi Sun, Guang-Li Shi
BACKGROUND: Mannose-binding lectin (MBL) is an important protein in the lectin pathway of the immune system. This study explores the association between MBL polymorphism and the susceptibility to tuberculosis (TB). The association between the MBL2 polymorphisms and serum MBL levels is also analyzed in the present study. METHODS: A total of 112 inpatients with pulmonary TB and 120 healthy controls were recruited to participate in this case-control study. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism(PCR-RFLP) technology was used to genotype MBL gene (variants in -221Y/X and exon l codons 54 A/B)...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28296924/changes-in-surface-glycosylation-and-glycocalyx-shedding-in-trichobilharzia-regenti-schistosomatidae-during-the-transformation-of-cercaria-to-schistosomulum
#3
Jana Řimnáčová, Libor Mikeš, Libuše Turjanicová, Jana Bulantová, Petr Horák
The invasive larvae (cercariae) of schistosomes penetrate the skin of their definitive hosts. During the invasion, they undergo dramatic ultrastructural and physiological transitions. These changes result in the development of the subsequent stage, schistosomulum, which migrates through host tissues in close contact with host's immune system. One of the striking changes in the transforming cercariae is the shedding of their thick tegumental glycocalyx, which represents an immunoattractive structure; therefore its removal helps cercariae to avoid immune attack...
2017: PloS One
https://www.readbyqxmd.com/read/28282442/characterization-of-c-type-lectins-reveals-an-unexpectedly-limited-interaction-between-cryptococcus-neoformans-spores-and-dectin-1
#4
Naomi M Walsh, Marcel Wuthrich, Huafeng Wang, Bruce Klein, Christina M Hull
Phagocytosis by innate immune cells is an important process for protection against multiple pathologies and is particularly important for resistance to infection. However, phagocytosis has also been implicated in the progression of some diseases, including the dissemination of the human fungal pathogen, Cryptococcus neoformans. Previously, we identified Dectin-1 as a likely phagocytic receptor for C. neoformans spores through the use of soluble components in receptor-ligand blocking experiments. In this study, we used gain-of-function and loss-of-function assays with intact cells to evaluate the in vivo role of Dectin-1 and other C-type lectins in interactions with C...
2017: PloS One
https://www.readbyqxmd.com/read/28262777/the-role-of-the-complement-system-in-diabetic-nephropathy
#5
REVIEW
Allan Flyvbjerg
The development of type 1 and type 2 diabetes mellitus has a substantial negative impact on morbidity and mortality and is responsible for substantial individual and socioeconomic costs worldwide. One of the most serious consequences of diabetes mellitus is the development of diabetic angiopathy, which manifests clinically as microvascular and macrovascular complications. One microvascular complication, diabetic nephropathy, is the most common cause of end-stage renal disease in developed countries. Although several available therapeutic interventions can delay the onset and progression of diabetic nephropathy, morbidity associated with this disease remains high and new therapeutic approaches are needed...
March 6, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28262211/complement-alternative-pathway-s-activation-in-patients-with-lupus-nephritis
#6
Di Song, Wei-Yi Guo, Feng-Mei Wang, Yong-Zhe Li, Yan Song, Feng Yu, Ming-Hui Zhao
OBJECTIVE: The aim of this study was to detect the spectrum of complement activation pathways in circulation and to assess their correlations with clinical and pathologic features in a large lupus nephritis cohort from China. MATERIALS AND METHODS: Plasma levels of C1q, mannose-binding lectin, C4d, Bb, C3, C3a, C5a and soluble C5b-9 were detected by enzyme-linked immunosorbent assay in 222 patients with active biopsy-proven lupus nephritis, 34 patients with lupus nephritis at remission, 82 patients with active systemic lupus erythematosus without renal involvement and 39 normal controls...
March 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28259967/enhanced-expression-of-%C3%AE-2-3-linked-sialic-acids-promotes-gastric-cancer-cell-metastasis-and-correlates-with-poor-prognosis
#7
Li Shen, Zhiguo Luo, Junbo Wu, Li Qiu, Ming Luo, Qing Ke, Xiaoxia Dong
Gastric cancer (GC) is a highly metastatic disease and one of the leading causes of cancer death in the world. Aberrant glycosylation is one of many molecular changes that accompany malignant transformation. This study was aimed at identification of glycan profiling changes in GC progression and its potential mechanisms. We employed a microarray with 91 lectins to compare the differential glycans in the three human GC cell lines, SGC-7901, BGC-823 and MGC-803. According to glycan-binding specificities of lectins, all GC cell lines expressed common sugar structures, such as mannose, galactose and fucose...
February 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28250938/mutation-of-tyr137-of-the-universal-escherichia-coli-fimbrial-adhesin-fimh-relaxes-the-tyrosine-gate-prior-to-mannose-binding
#8
Said Rabbani, Eva-Maria Krammer, Goedele Roos, Adam Zalewski, Roland Preston, Sameh Eid, Pascal Zihlmann, Martine Prévost, Marc F Lensink, Andrew Thompson, Beat Ernst, Julie Bouckaert
The most prevalent diseases manifested by Escherichia coli are acute and recurrent bladder infections and chronic inflammatory bowel diseases such as Crohn's disease. E. coli clinical isolates express the FimH adhesin, which consists of a mannose-specific lectin domain connected via a pilin domain to the tip of type 1 pili. Although the isolated FimH lectin domain has affinities in the nanomolar range for all high-mannosidic glycans, differentiation between these glycans is based on their capacity to form predominantly hydrophobic interactions within the tyrosine gate at the entrance to the binding pocket...
January 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28246614/mannose-binding-lectin-biologic-characteristics-and-role-in-the-susceptibility-to-infections-and-ischemia-reperfusion-related-injury-in-critically-ill-neonates
#9
REVIEW
Cinzia Auriti, Giusi Prencipe, Maria Moriondo, Iliana Bersani, Chiara Bertaina, Vito Mondì, Rita Inglese
The mannose-binding lectin (MBL) is a member of the collectin family, belonging to the innate immunity system. Genetic, biologic, and clinical properties of MBL have been widely investigated throughout the last decades, although some interesting aspects of its potential clinical relevance are still poorly understood. Low circulating concentrations of MBL have been associated with increased risk of infection and poor neurologic outcome in neonates. On the other hand, an excessive and uncontrolled inflammatory response by the neonatal intestine after the exposure to luminal bacteria, leading to an increased production of MBL, may be involved in the onset of necrotizing enterocolitis...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28223515/rational-design-of-adjuvants-targeting-the-c-type-lectin-mincle
#10
Alexiane Decout, Sandro Silva-Gomes, Daniel Drocourt, Sophie Barbe, Isabelle André, Francisco J Cueto, Thierry Lioux, David Sancho, Eric Pérouzel, Alain Vercellone, Jacques Prandi, Martine Gilleron, Gérard Tiraby, Jérôme Nigou
The advances in subunit vaccines development have intensified the search for potent adjuvants, particularly adjuvants inducing cell-mediated immune responses. Identification of the C-type lectin Mincle as one of the receptors underlying the remarkable immunogenicity of the mycobacterial cell wall, via recognition of trehalose-6,6'-dimycolate (TDM), has opened avenues for the rational design of such molecules. Using a combination of chemical synthesis, biological evaluation, molecular dynamics simulations, and protein mutagenesis, we gained insight into the molecular bases of glycolipid recognition by Mincle...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28221015/taking-orders-from-light-photo-switchable-working-inactive-smart-surfaces-for-protein-and-cell-adhesion
#11
Junji Zhang, Wenjing Ma, Xiao-Peng He, He Tian
Photoresponsive smart surfaces are promising candidates for a variety of applications in optoelectronics and sensing devices. The use of light as an order signal provides advantages of remote and noninvasive control with high temporal and spatial resolutions. Modification of the photoswitches with target biomacromolecules, such as peptides, DNA, and small molecules including folic acid derivatives and sugars, has recently become a popular strategy to empower the smart surfaces with an improved detection efficiency and specificity...
March 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28207759/investigations-on-therapeutic-glucocerebrosidases-through-paired-detection-with-fluorescent-activity-based-probes
#12
Wouter W Kallemeijn, Saskia Scheij, Sascha Hoogendoorn, Martin D Witte, Daniela Herrera Moro Chao, Cindy P A A van Roomen, Roelof Ottenhoff, Herman S Overkleeft, Rolf G Boot, Johannes M F G Aerts
Deficiency of glucocerebrosidase (GBA) causes Gaucher disease (GD). In the common non-neuronopathic GD type I variant, glucosylceramide accumulates primarily in the lysosomes of visceral macrophages. Supplementing storage cells with lacking enzyme is accomplished via chronic intravenous administration of recombinant GBA containing mannose-terminated N-linked glycans, mediating the selective uptake by macrophages expressing mannose-binding lectin(s). Two recombinant GBA preparations with distinct N-linked glycans are registered in Europe for treatment of type I GD: imiglucerase (Genzyme), contains predominantly Man(3) glycans, and velaglucerase (Shire PLC) Man(9) glycans...
2017: PloS One
https://www.readbyqxmd.com/read/28197138/genetic-and-phenotypic-screening-of-mannose-binding-lectin-in-relation-to-risk-of-recurrent-vulvovaginal-infections-in-women-of-north-india-a-prospective-cohort-study
#13
Namarta Kalia, Jatinder Singh, Sujata Sharma, Hardesh Arora, Manpreet Kaur
Recurrent Vulvovaginal Infections (RVVI) is common problem associated with women of reproductive age. The function and deleterious effect of Mannose Binding Lectin 2 (MBL2) common polymorphisms are reported to be associated with various diseases. However, the role of MBL2 promoter gene polymorphisms and their combined effect with structural variant along with Serum Mannose Binding Lectin (sMBL) levels in RVVI has not been investigated. The study included 258 RVVI cases and 203 age matched healthy controls. These were investigated for the distribution of MBL2 codon 54 and promoter polymorphisms by Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28157181/roles-of-n-glycans-in-the-polymerization-dependent-aggregation-of-mutant-ig-%C3%AE-chains-in-the-early-secretory-pathway
#14
Chiara Giannone, Claudio Fagioli, Caterina Valetti, Roberto Sitia, Tiziana Anelli
The polymeric structure of secretory IgM allows efficient antigen binding and complement fixation. The available structural models place the N-glycans bound to asparagines 402 and 563 of Ig-μ chains within a densely packed core of native IgM. These glycans are found in the high mannose state also in secreted IgM, suggesting that polymerization hinders them to Golgi processing enzymes. Their absence alters polymerization. Here we investigate their role following the fate of aggregation-prone mutant μ chains lacking the Cμ1 domain (μ∆)...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28150103/purification-biochemical-characterization-and-amino-acid-sequence-of-a-novel-type-of-lectin-from-aplysia-dactylomela-eggs-with-antibacterial-antibiofilm-potential
#15
Rômulo Farias Carneiro, Renato Cézar Farias Torres, Renata Pinheiro Chaves, Mayron Alves de Vasconcelos, Bruno Lopes de Sousa, André Castelo Rodrigues Goveia, Francisco Vassiliepe Arruda, Maria Nágila Carneiro Matos, Helena Matthews-Cascon, Valder Nogueira Freire, Edson Holanda Teixeira, Celso Shiniti Nagano, Alexandre Holanda Sampaio
A new lectin from Aplysia dactylomela eggs (ADEL) was isolated by affinity chromatography on HCl-activated Sepharose™ media. Hemagglutination caused by ADEL was inhibited by several galactosides, mainly galacturonic acid (Ka = 6.05 × 10(6) M(-1)). The primary structure of ADEL consists of 217 residues, including 11 half-cystines involved in five intrachain and one interchain disulfide bond, resulting in a molecular mass of 57,228 ± 2 Da, as determined by matrix-assisted laser desorption/ionization time of flight mass spectrometry...
February 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28144635/expression-analysis-of-lily-type-lectin-isotypes-in-the-rock-bream-oplegnathus-fasciatus-in-the-tissue-developmental-stage-and-viral-infection
#16
Young Mee Lee, In Jung Yang, Jae Koo Noh, Hyun Chul Kim, Choul-Ji Park, Jong-Won Park, Gyeong Eon Noh, Woo-Jin Kim, Kyung-Kil Kim
Lectins belong to the pattern-recognition receptors (PRRs) class and play important roles in the recognition and elimination of pathogens via the innate immune system. Recently, it was reported that lily-type lectin-1 is involved when a pathogen attacks in the early immune response of fish. However, this study is limited to information that the lectin is involved in the innate immune response against viral infection. In the present study, the lily-type lectin-2 and -3 of Oplegnathus fasciatus (OfLTL-2 and 3) have been presented to be included B-lectin domain and two D-mannose binding sites in the amino acid sequence that an important feature for the fundamental structure...
December 2016: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/28132614/insight-into-the-intermolecular-recognition-mechanism-involved-in-complement-component-4-activation-through-serine-protease-trypsin
#17
Vikrant Kumar Sinha, Om Prakash Sharma, Muthuvel Suresh Kumar
Serine protease cleaved-complement component 4 (C4) at sessile loop, which is significant for completion of lectin and classical complement pathways at the time of infections. The co-crystalized structure of C4 with Mannose-binding protein-associated serine protease 2 (MASP2) provided the structural and functional aspects of its interaction and underlined the C4 activation by MASP2. The same study also revealed the significance of complement control protein (CCP) domain through mutational study, where mutated CCP domain led to the inhibition of C4 activation...
February 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28130769/secretory-expression-and-characterization-of-chinese-narcissus-gna-like-lectin-in-pichia-pastoris
#18
Xinyu Li, Pengpeng Zhang, Ning Zhang, Xiao Liang, Wenya Wang, Qipeng Yuan, Qiang Li
Narcissus tazetta lectin (NTL) is a GNA-like lectin, which has a wide potential application in medicine, agriculture, and glycobiology. In the present paper, the codon-optimized ntl gene was transformed into the yeast Pichia pastoris; SDS-PAGE gel and western blotting analysis revealed that the recombinant lectin was expressed successfully in Pichia yeast. The similarity between the recombinant NTL and the native NTL was confirmed by circular dichroism (CD) and hemagglutination assay further. In the 5-L scale fermentator, the protein yield was as high as 1...
January 27, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28117986/sequence-controlled-glycopolymers-via-step-growth-polymerization-of-precision-glycomacromolecules-for-lectin-receptor-clustering
#19
Christoph Gerke, Morten F Ebbesen, Dennis Jansen, Sophia Boden, Tanja Freichel, Laura Hartmann
A versatile approach for the synthesis of sequence-controlled multiblock copolymers, using a combination of solid phase synthesis and step-growth polymerization by photoinduced thiol-ene coupling (TEC) is presented. Following this strategy, a series of sequence-controlled glycopolymers is derived from the polymerization of a hydrophilic spacer macromonomer and different glycomacromonomers bearing between one to five α-d-Mannose (Man) ligands. Through the solid phase assembly of the macromonomers, the number and positioning of spacer and sugar moieties is controlled and translates into the sequence-control of the final polymer...
March 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28111019/flexibility-in-mannan-binding-lectin-associated-serine-proteases-1-and-2-provides-insight-on-lectin-pathway-activation
#20
Ruodan Nan, Christopher M Furze, David W Wright, Jayesh Gor, Russell Wallis, Stephen J Perkins
The lectin pathway of complement is activated by complexes comprising a recognition component (mannose-binding lectin, serum ficolins, collectin-LK or collectin-K1) and a serine protease (MASP-1 or MASP-2). MASP-1 activates MASP-2, and MASP-2 cleaves C4 and C4b-bound C2. To clarify activation, new crystal structures of Ca(2+)-bound MASP dimers were determined, together with their solution structures from X-ray scattering, analytical ultracentrifugation, and atomistic modeling. Solution structures of the CUB1-EGF-CUB2 dimer of each MASP indicate that the two CUB2 domains were tilted by as much as 90° compared with the crystal structures, indicating considerable flexibility at the EGF-CUB2 junction...
February 7, 2017: Structure
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