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Mannose binding lectin

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https://www.readbyqxmd.com/read/28086930/mannose-binding-lectin-associated-serine-protease-2-masp-2-contributes-to-poor-disease-outcome-in-humans-and-mice-with-pneumococcal-meningitis
#1
E Soemirien Kasanmoentalib, Mercedes Valls Seron, Bart Ferwerda, Michael W Tanck, Aeilko H Zwinderman, Frank Baas, Arie van der Ende, Matthijs C Brouwer, Diederik van de Beek
BACKGROUND: Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the severity of the pro-inflammatory response in the subarachnoid space. The complement system, which mediates key inflammatory processes, has been implicated as a modulator of pneumococcal meningitis disease severity in animal studies. METHODS: We investigated mannose-binding lectin-associated serine protease (MASP-2) levels in cerebrospinal fluid (CSF) samples derived from the diagnostic lumbar puncture, which was available for 307 of 792 pneumococcal meningitis episodes included in our prospective nationwide cohort study (39%), and the association between these levels and clinical outcome...
January 3, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28079948/induction-of-antibodies-directed-against-branched-core-o-mannosyl-glycopeptides-selectivity-complimentary-to-the-cona-lectin
#2
Jin Yu, Oliver C Grant, Christian Pett, Sabine Strahl, Robert J Woods, Ulrika Westerlind
Mammalian protein O-mannosylation comprise a group of post-translational modifications (PTMs) involved in muscle and brain development. Despite the enormous progress made, to date the biological impact of the mammalian O-mannosyl glycoproteome remains largely unknown. Tools are still needed to investigate the structure, role and abundance of O-mannosyl glycans. While O-mannosyl branching has been shown to be of relevance in integrin-dependent cell-migration, and also plays a role in demyelinating diseases, a broader understanding of the biological roles of branched O-mannosyl glycans is lacking in part due to the paucity of detection tools...
January 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28069433/dual-recognition-activity-of-a-rhamnose-binding-lectin-to-pathogenic-bacteria-and-zooxanthellae-in-stony-coral-pocillopora-damicornis
#3
Zhi Zhou, Xiaopeng Yu, Jia Tang, Yunjie Zhu, Guangmei Chen, Liping Guo, Bo Huang
Rhamnose-binding lectin (RBL) is a type of Ca(2+)-independent lectin with tandem repeat carbohydrate-recognition domain, and is crucial for the innate immunity in many invertebrates. In this study, the cDNA sequence encoding RBL in coral Pocillopora damicornis (PdRBL-1) was cloned. The PdRBL-1 protein shared highest amino acid sequence similarity (55%) with the polyp of Hydra vulgaris, and contained a signal peptide and two tandem carbohydrate-recognition domains in which all cysteine residues were conserved...
January 6, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28056798/high-rate-of-in-stent-restenosis-after-coronary-intervention-in-carriers-of-the-mutant-mannose-binding-lectin-allele
#4
Zsolt Bagyura, Loretta Kiss, Balázs Berta, Ágnes Szilágyi, Kristóf Hirschberg, Gábor Széplaki, Árpád Lux, Zsolt Szelid, Pál Soós, Béla Merkely
BACKGROUND: In-stent restenosis occurs in 10-30% of patients following bare metal stent (BMS) implantation and has various risk factors. Mannose-binding lectin (MBL) is known to have effect on the progression of atherosclerosis. Single nucleotide polymorphisms (SNP) of the MBL2 gene intron 1 (codon 52, 54, 57) are known to modulate the bioavailability of the MBL protein. Our aim was to identify the association of these polymorphisms of the MBL gene in the occurrence of in-stent restenosis after coronary artery bare metal stent implantation...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28052761/increased-activity-of-the-complement-system-in-cerebrospinal-fluid-of-the-patients-with-non-hiv-cryptococcal-meningitis
#5
Lei Shen, Jianming Zheng, Yan Wang, Mengqi Zhu, Haoxiang Zhu, Qi Cheng, Qian Li
BACKGROUNDS: Cryptococcal meningitis (CM) has been known to lead to significant morbidity and mortality. The relative contribution of the complement system in protection and pathogenesis during CM remains largely unknown. The purpose of this study was to evaluate the baseline complement component profiles in human cerebrospinal fluid (CSF) and plasma from non-HIV patients with CM, and therefore to provide insights of possible roles of the complement system in CM. METHODS: CSF and blood samples from forty two CM patients not infected with HIV and thirteen non-CM control patients (Ctrl) were retrospectively selected and evaluated from the patients admitted to the hospital with a suspected diagnosis of CM...
January 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28046067/c-type-lectin-receptor-dectin-2-binds-to-an-endogenous-protein-%C3%AE-glucuronidase-on-dendritic-cells
#6
Daiki Mori, Kensuke Shibata, Sho Yamasaki
C-type lectin receptors (CLRs) recognize pathogen-derived ligands and abnormal self that trigger protective immune responses. However, the precise nature of self ligands recognized by CLRs remains to be determined. Here, we found that Dectin-2 recognizes bone marrow-derived dendritic cells (BMDCs) using Dectin-2-expressing reporter cells. This activity was inhibited by an excessive amount of mannose, and by the mutation of mannose-binding motif in Dectin-2. β-glucuronidase (Gusb) was identified as a protein bound to Dectin-2 and mutations of N-glycosylation sites in Gusb impaired the binding of Gusb to Dectin-2...
2017: PloS One
https://www.readbyqxmd.com/read/28032346/mannose-binding-lectin-and-l-ficolin-polymorphisms-in-patients-with-community-acquired-pneumonia-caused-by-intracellular-pathogens
#7
Gijs van Kempen, Sabine Meijvis, Hendrik Endeman, Bart Vlaminckx, Bob Meek, Ben de Jong, Ger T Rijkers, Willem Jan Bos
Community acquired pneumonia (CAP) is the leading infectious disease requiring hospitalisation in the Western World. Genetic variability affecting the host response to infection may play a role in susceptibility and outcome in CAP patients. Mannose binding lectin (MBL) and L-ficolin (L-FCN) are two important activators of the complement system and they can enhance phagocytosis by opsonisation. In a prospective cohort of 505 Dutch CAP patients and 227 controls we studied whether polymorphisms in the MBL (MBL2) and FCN (FCN2) genes influenced susceptibility and outcome...
December 29, 2016: Immunology
https://www.readbyqxmd.com/read/28029199/mannose-functionalized-hyperbranched-polyglycerol-loaded-with-zinc-porphyrin-investigation-of-the-multivalency-effect-in-antibacterial-photodynamic-therapy
#8
Arno Wiehe, Michael H Staegemann, Burkhard Gitter, Jens Dernedde, Christian Kuehne, Rainer Haag
The antibacterial photodynamic activity of hyperbranched polyglycerol loaded with zinc porphyrin photosensitizers and mannose units is investigated. hPG with a MW of 19.5 kDa has been functionalized with ~15 molecules of a zinc porphyrin photosensitizer using the copper(I)-catalyzed 1,3-dipolar cycloaddition. These nanoparticle conjugates have been functionalized with increasing loadings of mannose in the range of approx. 20-110 groups. With higher mannose loadings (approx. 58-110 groups) the water-insoluble zinc-porphyrin photosensitizer can thus be transferred into a water-soluble form...
December 28, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28011641/glycan-bound-to-the-selectin-low-affinity-state-engages-glu88-to-stabilize-the-high-affinity-state-under-force
#9
Padmaja Mehta-D'souza, Arkadiusz G Klopocki, Vaheh Oganesyan, Simon Terzyan, Timothy Mather, Zhenhai Li, Sumith R Panicker, Cheng Zhu, Rodger P McEver
Selectin interactions with fucosylated glycan ligands mediate leukocyte rolling in the vasculature under shear forces. Crystal structures of P- and E-selectin suggest a two-state model in which ligand binding to the lectin domain closes loop 83-89 around the Ca(2+)-coordination site, enabling Glu88 to engage Ca(2+) and fucose. This triggers further allostery that opens the lectin/EGF-domain hinge. The model posits that force accelerates transition from the bent (low-affinity) to the extended (high-affinity) state...
December 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27999137/cystatin-c-is-a-crucial-endogenous-protective-determinant-against-stroke
#10
Zongping Fang, Jiao Deng, Zhixin Wu, Beibei Dong, Shiquan Wang, Xiaodan Chen, Huang Nie, Hailong Dong, Lize Xiong
BACKGROUND AND PURPOSERESULTS: Endogenous neuroprotection can be induced by ischemic and nonischemic preconditioning. However, not all subjects that undergo preconditioning exhibit similar favorable outcome. This study is to explore the molecules responsible for this phenomenon and find new therapeutic targets for stroke. METHODS: Adult male Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion. High-throughput proteomic technique, isobaric tag for relative and absolute quantification, was used to screen differentially expressed proteins in the rats that developed ischemic tolerance from hyperbaric oxygen (HBO) preconditioning...
December 20, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27997520/polymorphisms-of-mannose-binding-lectin-and-toll-like-receptors-2-3-4-7-and-8-and-the-risk-of-respiratory-infections-and-acute-otitis-media-in-children
#11
Laura Toivonen, Juho Vuononvirta, Jussi Mertsola, Matti Waris, Qiushui He, Ville Peltola
BACKGROUND: Mannose-binding lectin (MBL) and toll-like receptors (TLR) are important components of the innate immune system. We assessed the susceptibility of children with genetic variants in these factors to respiratory infections, rhinovirus infections, and acute otitis media. METHODS: In a prospective cohort study, blood samples from 381 Finnish children were analyzed for polymorphisms in MBL2 at codons 52, 54, and 57, TLR2 Arg753Gln, TLR3 Leu412Phe, TLR4 Asp299Gly, TLR7 Gln11Leu, and TLR8 Leu651Leu...
December 15, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27982280/mannose-binding-lectin-2-mbl2-gene-polymorphisms-are-related-to-protein-plasma-levels-but-not-to-heart-disease-and-infection-by-chlamydia
#12
M A F Queiroz, S T M Gomes, N C C Almeida, M I M Souza, S R C F Costa, R B Hermes, S S Lima, M M Zaninotto, M A A Fossa, M A Maneschy, R N Martins-Feitosa, V N Azevedo, L F A Machado, M O G Ishak, R Ishak, A C R Vallinoto
The presence of the single nucleotide polymorphisms in exon 1 of the mannose-binding lectin 2 (MBL2) gene was evaluated in a sample of 159 patients undergoing coronary artery bypass surgery (71 patients undergoing valve replacement surgery and 300 control subjects) to investigate a possible association between polymorphisms and heart disease with Chlamydia infection. The identification of the alleles B and D was performed using real time polymerase chain reaction (PCR) and of the allele C was accomplished through PCR assays followed by digestion with the restriction enzyme...
December 12, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27931588/evaluation-of-mannose-binding-lectin-is-a-useful-approach-to-predict-the-risk-of-infectious-complications-following-autologous-hematopoietic-stem-cell-transplantation
#13
Z B Radnay, M Udvardy, M Papp, J Hársfalvi, L Rejto, I Pál, Á Illés, A Kiss
Hematopoietic stem cell transplantation (HSCT) associated immunocompromised state carries high risk of infectious complications. Mannose-binding lectin (MBL) is an acute phase protein involved in innate immune response. Serum MBL level is genetically determined and quite stable. According to literature, significant association was shown between low MBL concentrations and serious infections. The association between serum MBL level and frequency and severity of infections was studied in 186 patients following autologous HSCT...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27911110/mannose-binding-lectin-deficiency-in-brazilian-patients-with-spondyloarthritis
#14
Thelma L Skare, Renato Nisihara, Juliana Z Cieslinski, João O Zeni, Henrique N Rasera, Iara Messias-Reason, Shirley R R Utiyama
BACKGROUND: Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense. OBJECTIVE: To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical profile of these diseases. METHODS: We studied 89 SpA patients and 89 healthy individuals, paired for age and gender. MBL serum levels were measured by ELISA test...
December 2, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27909766/association-between-tlr2-tlr4-gene-polymorphisms-and-copd-phenotype-in-a%C3%A2-greek-cohort
#15
A Apostolou, T Kerenidi, A Michopoulos, K I Gourgoulianis, M Noutsias, A E Germenis, M Speletas
BACKGROUND: Considering that the innate immune system plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD), we hypothesized that functional single-nucleotide polymorphisms (SNPs) of innate immune genes affect the disease phenotype and prognosis. AIM: To elucidate the contribution of common functional TLR2 and TLR4 SNPs and genotypic deficiency of the mannose-binding lectin (MBL) protein, both as single parameters and in combination, in Greek COPD patients...
December 1, 2016: Herz
https://www.readbyqxmd.com/read/27876780/a-meta-analysis-of-mbl2-polymorphisms-and-tuberculosis-risk
#16
Mohammed Y Areeshi, Raju K Mandal, Naseem Akhter, Sajad A Dar, Arshad Jawed, Mohd Wahid, Harishankar Mahto, Aditya K Panda, Mohtashim Lohani, Shafiul Haque
MBL2 gene encodes mannose-binding lectin, is a member of innate immune system. Earlier studies revealed that MBL2 gene variants, rs1800451, rs1800450, rs5030737, rs7096206, rs11003125 and rs7095891 are associated with impaired serum level and susceptibility to TB, but their results are inconsistent. A meta-analysis was performed by including 22 studies (7095 TB-patients and 7662 controls) and data were analyzed with respect to associations between alleles, genotypes and minor allele carriers to evaluate the potential association between MBL2 polymorphisms and TB risk...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27874116/understanding-carbohydrate-protein-interactions-using-homologous-supramolecular-chiral-ru-ii-glyconanoclusters
#17
Harikrishna Bavireddi, Raghavendra Vasudeva Murthy, Madhuri Gade, Sivakoti Sangabathuni, Preeti Madhukar Chaudhary, Catherine Alex, Bernd Lepenies, Raghavendra Kikkeri
Multivalent glycodendrimers make promising tools to tackle the basic and translational research in the field of carbohydrate-mediated interactions. Despite advances in glycodendrimers and glycopolymers, the multivalent probes available to date are still far from being ideal biological mimics. This work demonstrates the inherent chirality of glycodendrimers to be one of the promising factors to generate different spatial carbohydrate micro-environments to modulate specific carbohydrate-protein interactions. By exploiting the host-guest strategy, chiral Ru(ii) complexes (Δ and Λ) and mannose capped β-cyclodextrin (β-CD), we generated a library of homologous metallo-glycodendrimers (MGDs) with sizes of 50-70 nm...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27871914/neonatal-levels-of-adiponectin-interleukin-10-and-interleukin-12-are-associated-with-the-risk-of-developing-type-1-diabetes-in-childhood-and-adolescence-a-nationwide-danish-case-control-study
#18
Steffen U Thorsen, Christian B Pipper, Stefanie Eising, Kristin Skogstrand, David M Hougaard, Jannet Svensson, Flemming Pociot
BACKGROUND/AIM: An in-depth understanding of the early phase of type 1 diabetes (T1D) pathogenesis is important for targeting primary prevention. We examined if 14 preselected mediators of immune responses differed in neonates that later developed T1D compared to control neonates. METHODS: The study is a case-control study with a 1:2 matching. The individuals were born between 1981 through 2002. Cases were validated using the National Patient Register and the Danish Childhood Diabetes Register...
November 15, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27871013/tri-and-tetravalent-mannoclusters-cross-link-and-aggregate-bc2l-a-lectin-from-burkholderia-cenocepacia
#19
Magdolna Csávás, Lenka Malinovská, Florent Perret, Milán Gyurkó, Zita Tünde Illyés, Michaela Wimmerová, Anikó Borbás
The opportunistic Gram-negative bacterium Burkholderia cenocepacia causes lethal infections in cystic fibrosis patients. Multivalent mannoside derivatives were prepared as potential inhibitors of lectin BC2L-A, one of the virulence factors deployed by B. cenocepacia in the infection process. An (α1→2)-thio-linked mannobioside mimic bearing an azide functionalized aglycon was conjugated to different multivalent scaffolds such as propargylated calix[4]arenes, methyl gallate and pentaerythritol by azide-alkyne 1,3-dipolar cycloaddition...
January 2, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/27857715/complementary-roles-of-the-classical-and-lectin-complement-pathways-in-the-defense-against-aspergillus-fumigatus
#20
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Mikkel-Ole Skjoedt, Gregory L Stahl, Peter Garred
Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear. The aim of this study was to unravel the role of the classical, lectin, and alternative pathways under both immunocompetent and immunocompromised conditions to provide a relevant dual-perspective on the response against A. fumigatus. Conidia (spores) from a clinical isolate of A...
2016: Frontiers in Immunology
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