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Impulse control disorder and parkinson

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https://www.readbyqxmd.com/read/27913125/apomorphine-therapy-in-parkinson-s-and-future-directions
#1
Nataliya Titova, K Ray Chaudhuri
Apomorphine infusion or injection is an important dopamine agonist non-oral therapy usually used in advanced Parkinson's disease (PD) with refractory motor fluctuations. The drug also has appreciable efficacy for nonmotor fluctuations and is the quickest to reverse predictable "off" periods. Current subcutaneous administration, however, is complicated by problems associated with needle-based therapies, such as skin nodule formation, skin irritation, and avoidance of this treatment option by needle-phobic subjects...
November 30, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27911342/impulsive-and-compulsive-behaviors-in%C3%A2-parkinson-disease-the-norwegian-parkwest-study
#2
Aleksander H Erga, Guido Alves, Jan Petter Larsen, Ole Bj Rn Tysnes, Kenn Freddy Pedersen
BACKGROUND: Impulsive and compulsive behaviors (ICBs) are frequent in Parkinson's disease (PD), but data from population-based cohorts is lacking. OBJECTIVES: To determine the frequency and associated demographic, clinical, neuropsychiatric and cognitive features of ICBs in a population-based PD cohort. METHODS: This cross-sectional study included 125 patients with PD and 159 age- and gender-matched normal controls recruited from the Norwegian ParkWest study...
November 30, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27889491/pramipexole-enhances-disadvantageous-decision-making-lack-of-relation-to-changes-in-phasic-dopamine-release
#3
Romina Pes, Sean C Godar, Andrew T Fox, Lauren M Burgeno, Hunter J Strathman, David P Jarmolowicz, Paola Devoto, Beth Levant, Paul E M Phillips, Stephen C Fowler, Marco Bortolato
Pramipexole (PPX) is a high-affinity D2-like dopamine receptor agonist, used in the treatment of Parkinson's disease (PD) and restless leg syndrome. Recent evidence indicates that PPX increases the risk of problem gambling and impulse-control disorders in vulnerable patients. Although the molecular bases of these complications remain unclear, several authors have theorized that PPX may increase risk propensity by activating presynaptic dopamine receptors in the mesolimbic system, resulting in the reduction of dopamine release in the nucleus accumbens (NAcc)...
November 23, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27848033/impaired-learning-of-punishments-in-parkinson-s-disease-with-and-without-impulse-control-disorder
#4
Bernd Leplow, Maria Sepke, Robby Schönfeld, Johannes Pohl, Henriette Oelsner, Lea Latzko, Georg Ebersbach
To document specific learning mechanisms in patients with Parkinson's disease (PD) with and without impulse control disorder (ICD). Thirty-two PD patients receiving dopamine replacement therapy (DRT) were investigated. Sixteen were diagnosed with ICD (ICD (+) ) and 16 PD patients matched for levodopa equivalence dosage, and DRT duration and severity of disease did not show impulsive behavior (non-ICD). Short-term learning of inhibitory control was assessed by an experimental procedure which was intended to mimic everyday life...
November 15, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27803657/pramipexole-increases-go-timeouts-but-not-no-go-errors-in-healthy-volunteers
#5
Xue Qing Yang, Daniel Glizer, Andrew Vo, Ken N Seergobin, Penny A MacDonald
Parkinson's disease (PD) is characterized by motor symptoms, such as resting tremor, bradykinesia and rigidity, but also features non-motor complications. PD patients taking dopaminergic therapy, such as levodopa but especially dopamine agonists (DAs), evidence an increase in impulse control disorders (ICDs), suggesting a link between dopaminergic therapy and impulsive pursuit of pleasurable activities. However, impulsivity is a multifaceted construct. Motor impulsivity refers to the inability to overcome automatic responses or cancel pre-potent responses...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27774496/parkinson-s-impulse-control-scale-for-the-severity-rating-of-impulse-control-behaviors-in-parkinson-s-disease-a-semistructured-clinical-assessment-tool
#6
David Okai, Sally Askey-Jones, Joel Mack, Anne Martin, Kallol Ray Chaudhuri, Michael Samuel, Anthony S David, Richard G Brown
BACKGROUND: Impulse-control behaviors (ICBs) are increasingly recognized in Parkinson's disease (PD) as drug-related effects of dopaminergic mediation that occur in 15% to 35% of patients with PD. The authors describe the design and evaluation of a new, clinician-rated severity scale for the assessment of syndromal and subsyndromal forms of impulse-control disorders (ICDs), simple (punding) and complex (hobbyism) repetitive behaviors, and compulsive overuse of medication (dopamine dysregulation syndrome)...
September 2016: Movement Disorders Clinical Practice
https://www.readbyqxmd.com/read/27761641/impulse-control-behaviors-and-subthalamic-deep-brain-stimulation-in-parkinson-disease
#7
Aristide Merola, Alberto Romagnolo, Laura Rizzi, Mario Giorgio Rizzone, Maurizio Zibetti, Michele Lanotte, George Mandybur, Andrew P Duker, Alberto J Espay, Leonardo Lopiano
To determine the clinical and demographic correlates of persistent, remitting, and new-onset impulse control behaviors (ICBs) before and after subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We compared the pre- and post-surgical prevalence of ICBs, classified as impulse control disorders (ICD), dopamine dysregulation syndrome (DDS), and punding in 150 consecutive PD STN-DBS-treated patients and determined the association with motor, cognitive, neuropsychological, and neuropsychiatric endpoints...
October 19, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27746069/neuropsychiatric-complications-of-parkinson-disease-treatments-importance-of-multidisciplinary-care
#8
Jacob Taylor, William S Anderson, Jason Brandt, Zoltan Mari, Gregory M Pontone
Although Parkinson disease (PD) is defined clinically by its motor symptoms, it is increasingly recognized that much of the disability and worsened quality of life experienced by patients with PD is attributable to psychiatric symptoms. The authors describe a model of multidisciplinary care that enables these symptoms to be effectively managed. They describe neuropsychiatric complications of PD itself and pharmacologic and neurostimulation treatments for parkinsonian motor symptoms and discuss the management of these complications...
December 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27714426/chronic-administration-of-the-dopamine-d2-3-agonist-ropinirole-invigorates-performance-of-a-rodent-slot-machine-task-potentially-indicative-of-less-distractible-or-compulsive-like-gambling-behaviour
#9
Paul J Cocker, M Tremblay, S Kaur, Catharine A Winstanley
RATIONALE: Whilst dopamine agonist therapies can successfully manage the symptoms of diseases such as Parkinson's disease (PD), fibromyalgia and restless leg syndrome, they can also cause impulse control and addiction disorders such as gambling disorder (GD). These compulsive behaviours seriously undermine the utility of such treatments. OBJECTIVES: The objective of the study was to model this phenomenon using a rodent slot machine task (rSMT) in order to investigate the neurobiological basis underlying such behavioural changes...
October 6, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27711942/reversible-valproic-acid-induced-parkinsonism-and-cognitive-impairment-in-an-elderly-patient-with-bipolar-disorder-i
#10
Sameer Hassamal, Susan Waller, Kimberly Reese, Claudia Testa
Valproic acid (VPA) is approved by the Food and Drug Administration (FDA) for the treatment of manic or mixed episodes associated with bipolar disorder. VPA is also used off-label to treat other conditions in psychiatry such as impulse control disorders, major depression, and posttraumatic stress disorder (PTSD). Although VPA is mostly well-tolerated, common adverse effects include gastrointestinal symptoms (nausea, vomiting, diarrhea), neurological symptoms (sedation, ataxia, tremor), weight gain, and alopecia...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/27618110/deep-brain-stimulation-in-search-of-reliable-instruments-for-assessing-complex-personality-related-changes
#11
Christian Ineichen, Heide Baumann-Vogel, Markus Christen
During the last 25 years, more than 100,000 patients have been treated with Deep Brain Stimulation (DBS). While human clinical and animal preclinical research has shed light on the complex brain-signaling disturbances that underpin e.g., Parkinson's disease (PD), less information is available when it comes to complex psychosocial changes following DBS interventions. In this contribution, we propose to more thoroughly investigate complex personality-related changes following deep brain stimulation through refined and reliable instruments in order to help patients and their relatives in the post-surgery phase...
September 7, 2016: Brain Sciences
https://www.readbyqxmd.com/read/27603211/use-of-an-enactive-insole-for-reducing-the-risk-of-falling-on-different-types-of-soil-using-vibrotactile-cueing-for-the-elderly
#12
Martin J-D Otis, Johannes C Ayena, Louis E Tremblay, Pascal E Fortin, Bob-Antoine J Ménélas
BACKGROUND: Our daily activities imply displacements on various types of soil. For persons with gait disorder or losing functional autonomy, walking on some types of soil could be challenging because of the risk of falling it represents. METHODS: In this paper, we present, in a first part, the use of an enactive shoe for an automatic differentiation of several types of soil. In a second part, using a second improved prototype (an enactive insole), twelve participants with Parkinson's disease (PD) and nine age-matched controls have performed the Timed Up and Go (TUG) test on six types of soil with and without cueing...
2016: PloS One
https://www.readbyqxmd.com/read/27590295/impulsive-compulsive-behaviors-in-parkin-associated-parkinson-disease
#13
Francesca Morgante, Alfonso Fasano, Monia Ginevrino, Simona Petrucci, Lucia Ricciardi, Francesco Bove, Chiara Criscuolo, Marcello Moccia, Anna De Rosa, Chiara Sorbera, Anna Rita Bentivoglio, Paolo Barone, Giuseppe De Michele, Maria Teresa Pellecchia, Enza Maria Valente
OBJECTIVE: The aim of this multicenter, case-control study was to investigate the prevalence and severity of impulsive-compulsive behaviors (ICBs) in a cohort of patients with parkin-associated Parkinson disease (PD) compared to a group of patients without the mutation. METHODS: We compared 22 patients with biallelic parkin mutations (parkin-PD) and 26 patients negative for parkin, PINK1, DJ-1, and GBA mutations (PD-NM), matched for age at onset, disease duration, levodopa, and dopamine agonist equivalent daily dose...
October 4, 2016: Neurology
https://www.readbyqxmd.com/read/27562098/long-term-safety-and-effectiveness-of-pramipexole-in-tetrahydrobiopterin-deficiency
#14
Francesco Porta, Alberto Ponzone, Marco Spada
Tetrahydrobiopterin (BH4) deficiencies are inherited neuro-metabolic disorders leading to monoamine neurotransmitters deficiency. An individualized replacement therapy with neurotransmitters precursors is necessary to restore dopaminergic and serotoninergic homeostasis. The correction of dopaminergic tone is complicated, like in Parkinson disease, by l-dopa short half-life and adverse effects. To improve this picture, since 2009 we introduced the non-ergot dopamine agonist pramipexole as an adjunct to l-dopa therapy in the treatment of the most common causes of BH4 deficiency, 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency and dihydropteridine reductase (DHPR) deficiency...
December 0: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27538621/the-high-prevalence-of-impulse-control-behaviors-in-patients-with-early-onset-parkinson-s-disease-a-cross-sectional-multicenter-study
#15
L Vela, J C Martínez Castrillo, P García Ruiz, C Gasca-Salas, Y Macías Macías, E Pérez Fernández, I Ybot, E Lopez Valdés, M M Kurtis, I J Posada Rodriguez, M Mata, C Ruiz Huete, M Eimil, C Borrue, J Del Val, L López-Manzanares, A Rojo Sebastian, R Marasescu
INTRODUCTION: In Parkinson's disease patients, impulse control disorders (ICDs) have been associated with younger age and early disease onset, yet the prevalence of ICDs in early-onset Parkinson's disease (EOPD) patients has yet to be studied. Thus, we set out to compare the prevalence of impulse control behaviors (ICBs) in a cohort of EOPD patients with that in age and gender matched healthy controls (HCs), as well as to analyze the association of these symptoms with the use of dopaminergic drugs and other clinical or demographic factors...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27473645/impulse-control-disorders-in-parkinson-s-disease-predominant-role-of-psychological-determinants
#16
Jack K Garlovsky, Jane Simpson, Richard A Grünewald, Paul G Overton
OBJECTIVES: Impulse Control Disorders (ICDs) in Parkinson's disease (PD) have previously almost exclusively been considered to result from anti-parkinsonian medication. However, this biomedical perspective has failed to achieve a full understanding of the phenomenon and it is argued that a failure to consider psychological factors is a critical omission. DESIGN: The present study examined the predictive relationship between ICDs in PD and a range of psychological measures, whilst controlling for a number of biomedical determinants...
December 2016: Psychology & Health
https://www.readbyqxmd.com/read/27472000/-german-translation-and-validation-of-the-scale-for-evaluation-of-neuropsychiatric-disorders-in-parkinson-s-disease-send-pd
#17
A Meyer, A Hadinia, F Hatz, P Martínez-Martín, P Fuhr, R D Stieglitz, U Gschwandtner
OBJECTIVE: The aim of the present study was to validate and provide a German version of the Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's disease (SEND-PD) of Martínez-Martín et al. (2012). METHOD: The German version of the SEND-PD was evaluated in a sample consisting of 96 patients with Parkinson's disease (PD) (mean age: 65.3 years ± 9.6, 29 female). This scale includes 12 items, representing the domains psychotic symptoms, mood/apathy and impulse control disorders...
July 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27460484/a-multidimensional-approach-to-impulsivity-in-parkinson-s-disease-measurement-and-structural-invariance-of-the-upps-impulsive-behaviour-scale
#18
S Bayard, E Joly, P Ghisletta, A Rossignol, Y Herades, C Geny, M-C Gély-Nargeot, L Rochat
BACKGROUND: Poor impulse control is a common feature in patients with Parkinson's disease (PD). However, before testing whether patients with PD and controls differ in impulsivity, one must assess whether impulsivity measures are invariant across groups. Consequently, we examined (a) the measurement and structural invariance of a scale assessing changes in four dimensions of impulsivity (urgency, lack of premeditation, lack of perseverance and sensation seeking) among patients with PD and controls; and (b) whether the four impulsivity traits relate differentially to risky decisions by patients...
October 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27425586/impulse-control-disorder-related-behaviours-during-long-term-rotigotine-treatment-a-post-hoc-analysis
#19
A Antonini, K R Chaudhuri, B Boroojerdi, M Asgharnejad, L Bauer, F Grieger, D Weintraub
BACKGROUND AND PURPOSE: Dopamine agonists in Parkinson's disease (PD) are associated with impulse control disorders (ICDs) and other compulsive behaviours (together called ICD behaviours). The frequency of ICD behaviours reported as adverse events (AEs) in long-term studies of rotigotine transdermal patch in PD was evaluated. METHODS: This was a post hoc analysis of six open-label extension studies up to 6 years in duration. Analyses included patients treated with rotigotine for at least 6 months and administered the modified Minnesota Impulse Disorders Interview...
October 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27422144/chronic-d2-3-agonist-ropinirole-treatment-increases-preference-for-uncertainty-in-rats-regardless-of-baseline-choice-patterns
#20
Melanie Tremblay, Mason M Silveira, Sukhbir Kaur, Jay G Hosking, Wendy K Adams, Christelle Baunez, Catharine A Winstanley
D2/3 receptor agonists are effective treatments for Parkinson's disease (PD), but can precipitate impulse control disorders (ICDs) including gambling disorder (GD). The neurobiological mechanisms underlying this devastating side-effect of dopamine agonist replacement therapy (DRT), and any dependence on the dopamine depletion caused by PD, are unclear. It is also unclear whether previous biases towards risk or uncertainty are a risk factor for developing these ICDs. We investigated whether chronic D2/3 agonist administration (5 mg/kg/day ropinirole for 28 days) altered performance of a rat model of gambling-like behaviour, the rodent betting task (rBT), and examined if baseline behaviour predicted this behavioural change...
July 16, 2016: European Journal of Neuroscience
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