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JOURNAL ARTICLE
Nasim Goudarzi, Ronak Shabani, Fatemeh Moradi, Marzieh Ebrahimi, Majid Katebi, Amir Jafari, Shayesteh Mehdinejadiani, Gelareh Vahabzade, Mansoure Soleimani
The extracellular matrix is recognized as an efficient and determining component in the growth, proliferation, and differentiation of cells due to its ability to perceive and respond to environmental signals. Applying three-dimensional scaffolds can create conditions similar to the extracellular matrix and provide an opportunity to investigate cell fate. In this study, we employed the PuraMatrix hydrogel scaffold as an advanced cell culture platform for the neural differentiation of stem cells derived from human breastmilk to design an opportune model for tissue engineering...
April 20, 2024: Brain Research
#22
JOURNAL ARTICLE
Maryum Fakhar, Mehboob Ahmed, Anjum Nasim Sabri
Pseudomonas aeruginosa is a Gram-negative opportunistic bacterium, ubiquitously found in nature and causative agent in many infections. Due to increased antibiotic resistance, there is a need to develop more robust antibacterial agents from natural sources. In this study, we worked on two metallo-β-lactamase (MBL) producing Pseudomonas aeruginosa strains and targeted the Quorum Sensing mechanism (QS) of these bacteria to combat antibiotic resistance. Our study aimed at using phytochemicals which have been used since centuries in herbal medicine...
June 2024: Saudi Journal of Biological Sciences
#23
JOURNAL ARTICLE
Annette Bauer, Martin Knapp, Mohsin Alvi, Nasim Chaudhry, Alain Gregoire, Abid Malik, Siham Sikander, Kiran Tayyeba, Ahmed Waqas, Nusrat Husain
BACKGROUND: Women's mental health during the perinatal period is a major public health problem in Pakistan. Many challenges and competing priorities prevent progress to address the large treatment gap. Aim To quantify the long-term impacts of untreated perinatal depression and anxiety in economic terms, thus highlighting its overall burden based on country-specific evidence. METHODS: Cost estimates were generated for a hypothetical cohort of women giving birth in 2017, and their children...
April 18, 2024: Journal of Affective Disorders
#24
JOURNAL ARTICLE
Nasim Bashour, Arash Aminpour, Shabnam Vazifehkhah, Rasool Jafari
Toxoplasmosis is a frequent infection among the human population. The infection can cause devastating complications for the fetus during pregnancy. The present study aimed to determine the serological and molecular prevalence of the infection and molecular characterization of Toxoplasma gondii isolates among pregnant women referred to Kowsar Hospital, Urmia, Iran. In a cross-sectional study, 340 blood samples were collected from pregnant women referred to Kowsar Hospital, Urmia, Iran from May to July 2022. Anti-T...
April 17, 2024: BMC Infectious Diseases
#25
REVIEW
Md Nasim Reza, Md Razob Ali, Samsuzzaman, Md Shaha Nur Kabir, Md Rejaul Karim, Shahriar Ahmed, Hyunjin Kyoung, Gookhwan Kim, Sun-Ok Chung
Pig farming, a vital industry, necessitates proactive measures for early disease detection and crush symptom monitoring to ensure optimum pig health and safety. This review explores advanced thermal sensing technologies and computer vision-based thermal imaging techniques employed for pig disease and piglet crush symptom monitoring on pig farms. Infrared thermography (IRT) is a non-invasive and efficient technology for measuring pig body temperature, providing advantages such as non-destructive, long-distance, and high-sensitivity measurements...
January 2024: Journal of Animal Science and Technology
#26
JOURNAL ARTICLE
Cyrus Jalili, Ardeshir Abbasi, Nasim Rahmani-Kukia, Salar Andarzi, Seyran Kakebaraie, Touraj Zamir Nasta
Aflatoxins B1 (AFB1) a dangerous type of aflatoxin, poses a serious threat to human health. Meanwhile, Taraxasterol, a bioactive compound in dandelion, exhibits strong anti-inflammatory and antioxidant activity. Therefore, the aim of this study was to investigate the impact of AFB1 on the intrinsic and extrinsic pathways of apoptosis, as well as evaluate the protective role of taraxasterol in the TM3 Leydig cell line. Cell viability was evaluated using an MTT assay, measuring the effects of 3.6 µM AFB1 and varying concentrations of taraxasterol...
April 13, 2024: Ecotoxicology and Environmental Safety
#27
JOURNAL ARTICLE
Ashley Lam, Milan K Piya, Nasim Foroughi, Mohammed Mohsin, Ritesh Chimoriya, Nic Kormas, Janet Conti, Phillipa Hay
This study aimed to examine the potential predictors of improvement in mental health outcomes following participation in an intensive non-surgical outpatient weight management program (WMP) in an Australian public hospital. This was a retrospective cohort study of all adults with Class 3 obesity (BMI ≥ 40 kg/m2 ) who enrolled in the WMP from March 2018 to June 2021. The participants completed the Eating Disorder Examination Questionnaire Short Version (EDE-QS), Kessler-10 Psychological Distress Scale, and 36-Item Short-Form Survey (SF-36) at baseline and 12-month follow-up...
April 5, 2024: Nutrients
#28
JOURNAL ARTICLE
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphael Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, James Mullikin, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian T Mayer, Sergio D Rosenzweig, Luigi D Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean-Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
The linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage disease. In mice, the loss of Sharpin leads to severe dermatitis due to excessive keratinocyte cell death. Here, we report two individuals with SHARPIN deficiency who manifest autoinflammatory symptoms but unexpectedly no dermatological problems. Fibroblasts and B cells from these individuals showed attenuated canonical NF-κB responses and a propensity for cell death mediated by TNF superfamily members...
April 12, 2024: Nature Immunology
#29
JOURNAL ARTICLE
Ezat Mohammed Anini, Taha Mahmoud AlBaik, Ahmed Tayseer Ibrahim, Nasim Afif AbuKaresh, Maram Albandak, Rafat Alshalaldeh, Motaz Natsheh, Fawzy M Abunejma
Kikuchi-Fujimoto disease (KFD) is a benign and self-limited disorder that usually presents with regional cervical lymphadenopathy and fever. We report a case of a 12-year-old female who complained of fever, night sweating, significant weight loss, and tender right cervical lymph node enlargement for 2 months. A full workup including laboratory tests and imaging studies, an excisional biopsy, and histopathological analysis were done, and the diagnosis of KFD was confirmed. The patient was treated with analgesia and oral prednisolone, resulting in good improvement...
2024: Journal of Investigative Medicine High Impact Case Reports
#30
JOURNAL ARTICLE
Kyra Guy, Ava Ritchie, Peninah Tumuhimbise, Emmanuel Balinda, Khoban Nasim, Moses Kalanzi, Heather Wipfli
BACKGROUND: Drowning is a major cause of death in Uganda, especially among young adults with water-based occupations and livelihoods. Information about drowning and other water-related deaths and injuries is limited. To address this gap in knowledge, study partners assessed knowledge, attitudes and beliefs about drowning and drowning prevention interventions in the Mayuge district of eastern Uganda. METHODS: This study consisted of a mixed-methods, cross-sectional community health assessment...
April 10, 2024: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
#31
JOURNAL ARTICLE
A S M Nasim, Abu Bakkar Siddique, Nishrita Devnath, Zebunnesa Zeba
OBJECTIVES: This study aims to evaluate the prevalence and associated factors of lower back pain (LBP) among farmers, rickshaw pullers and office workers in Bangladesh, while also investigating potential contributors within these occupational groups. DESIGN: This cross-sectional study aimed to determine the prevalence of LBP, associated factors and management procedures among farmers, rickshaw pullers and office workers in Bangladesh through face-to-face interviews...
April 11, 2024: BMJ Open
#32
JOURNAL ARTICLE
Julia G Mannheim, Jessie Fanglu Fu, Tilman Wegener, Ivan S Klyuzhin, Nasim Vafai, Elham Shahinfard, Jessamyn McKenzie, Audrey Strongosky, Zbigniew K Wszolek, A Jon Stoessl, Vesna Sossi
Several genetic pathogenic variants increase the risk of Parkinson's disease (PD) with pathogenic variants in the leucine-rich repeat kinase 2 (LRRK2) gene being among the most common. A joint pattern analysis based on multi-set canonical correlation analysis (MCCA) was utilized to extract PD and LRRK2 pathogenic variant-specific spatial patterns in relation to healthy controls (HCs) from multi-tracer Positron Emission Tomography (PET) data. Spatial patterns were extracted for individual subject cohorts, as well as for pooled subject cohorts, to explore whether complementary spatial patterns of dopaminergic denervation are different in the asymptomatic and symptomatic stages of PD...
April 1, 2024: NeuroImage: Clinical
#33
JOURNAL ARTICLE
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
The identification of genetic and chemical perturbations with similar impacts on cell morphology can elucidate compounds' mechanisms of action or novel regulators of genetic pathways. Research on methods for identifying such similarities has lagged due to a lack of carefully designed and well-annotated image sets of cells treated with chemical and genetic perturbations. Here we create such a Resource dataset, CPJUMP1, in which each perturbed gene's product is a known target of at least two chemical compounds in the dataset...
April 9, 2024: Nature Methods
#34
JOURNAL ARTICLE
Savannah G Phillips, Alyssa R Lankone, Sophia Sommerkamp O'Hagan, Nasim Ganji, D Howard Fairbrother
A suite of acyl chloride structural isomers (C6 H11 OCl) was used to effect gas-phase esterification of starch-based phytoglycogen nanoparticles (PhG NPs). The surface degree of substitution (DS) was quantified using X-ray photoelectron spectroscopy, while the overall DS was quantified using 1 H NMR spectroscopy. Gas-phase modification initiates at the NP surface, with the extent of surface and overall esterification determined by both the reaction time and the steric footprint of the acyl chloride reagent...
April 9, 2024: Biomacromolecules
#35
JOURNAL ARTICLE
Sabhita Shabir Shaikh, Badder Hina Afnan, Sumaira Nasim, Waqas Ahmed Farooqi, Ahsan Ali Darbari, Alveena Shabbir
OBJECTIVE: To evaluate the outcomes of nutritional intervention on non-alcoholic fatty liver disease parameters, and to determine the reasons for non-compliance with nutritional therapy. METHODS: The interventional study was conducted from May 2020 to October 2022 at the National Institute of Liver and Gastrointestinal diseases, Dow University Hospital, Ojha Campus, Karachi, and comprised patients of either gender aged 18-65 years who had been diagnosed with non-alcoholic fatty liver disease based on abdominal ultrasound...
March 2024: JPMA. the Journal of the Pakistan Medical Association
#36
JOURNAL ARTICLE
Shahrzad Nazari, Mitra-Sadat Sadat-Shirazi, Ali Shahbazi, Kamran Ghaffari, Nasim Vousooghi
Opioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system. Meanwhile, opioid addiction may affect the expression level of NMDA receptor subunits. The existence of GluN3 subunits in the NMDA receptor's tetramer structure reduces the excitatory current of the receptor channel. We evaluated the changes in the mRNA expression pattern of the GluN3B subunit of the NMDA receptor in rat brains following acute and chronic exposure to morphine...
March 28, 2024: Acta Neurobiologiae Experimentalis
#37
REVIEW
Ultrasound and magnetic resonance imaging features of fetal urogenital anomalies: A pictorial essay.
Behnaz Moradi, Mohammad Hossein Golezar, Reihaneh Mortazavi Ardestani, Sara Hassanzadeh, Payam Jannatdoust, Masoumeh Banihashemian, Nasim Batavani
This pictorial essay focuses on ultrasound (US) and magnetic resonance imaging (MRI) features of fetal urogenital anomalies. Fetal urogenital malformations account for 30%-50% of all anomalies discovered during pregnancy or at birth. They are usually detected by fetal ultrasound exams. However, when ultrasound data on their characteristics is insufficient, MRI is the best option for detecting other associated anomalies. The prognosis highly depends on their type and whether they are associated with other fetal abnormalities...
April 8, 2024: Congenital Anomalies
#38
REVIEW
Kunal Joshi, Daniel M Espino, Duncan Et Shepherd, Nasim Mahmoodi, Keith J Roberts, Nikolaos Chatzizacharias, Ravi Marudanayagam, Robert P Sutcliffe
Postoperative pancreatic fistula (POPF) is a major cause of morbidity and mortality after pancreatoduodenectomy (PD), and previous research has focused on patient-related risk factors and comparisons between anastomotic techniques. However, it is recognized that surgeon experience is an important factor in POPF outcomes, and that there is a significant learning curve for the pancreatic anastomosis. The aim of this study was to review the current literature on training models for the pancreatic anastomosis, and to explore areas for future research...
April 1, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
#39
JOURNAL ARTICLE
Julien Lombardi, Long Yang, Nasim Farahmand, Anthony Ruffino, Ali Younes, Jonathan E Spanier, Simon J L Billinge, Stephen O'Brien
The prospect of creating ferroelectric or high permittivity nanomaterials provides motivation for investigating complex transition metal oxides of the form Ba(Ti, MV)O3, where M = Nb or Ta. Solid state processing typically produces mixtures of crystalline phases, rarely beyond minimally doped Nb/Ta. Using a modified sol-gel method, we prepared single phase nanocrystals of Ba(Ti, M)O3. Compositional and elemental analysis puts the empirical formulas close to BaTi0.5Nb0.5O3-δ and BaTi0.5Ta0.5O3-δ...
April 7, 2024: Journal of Chemical Physics
#40
REVIEW
Peyman Mirghaderi, Hediye Gholamshahi, Ali Jahromi, Arad Iranmehr, Mohammad Amin Dabbagh-Ohadi, Nasim Eshraghi
BACKGROUND: Without clear signs of infection, spinal implant failure is attributed to mechanical overloads and aseptic loosening. However, how low-grade infections contribute to seemingly aseptic implant failure is unclear. PURPOSE: The systematic review examined unexpected positive cultures (UPCs) in revision spine surgery regarding prevalence, isolated pathogens, risk factors, and strategies to reduce infection among asymptomatic patients undergoing revision spine surgery...
April 4, 2024: European Spine Journal
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