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https://www.readbyqxmd.com/read/28727977/the-vanishing-twin-syndrome-two-cases-of-extreme-malformations-associated-with-vanished-twins
#1
Julia K Shinnick, Nasim Khoshnam, Sydney R Archer, Philip C Quigley, Haynes Robinson, Sarah Keene, Matthew T Santore, Sarah Hill, Binita Patel, Bahig M Shehata
Two cases of devastating fetal malformations associated with vanished monochorionic twins were identified upon review of pathology files. A 35-year-old G1P0 woman and 36-year-old G3P1 woman were both diagnosed with an intrauterine twin gestation via transvaginal ultrasound at 10 weeks. The spectrum of fetal anomalies ranged from omphalocele, bilateral upper extremity, and unilateral lower extremity hypoplasia, to craniofacial malformation with diaphragmatic hernia. On histopathologic examination, the placentas demonstrated vascular anastomoses between the surviving co-twin and the "vanished" fetal sac...
July 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28726806/data-sharing-as-a-national-quality-improvement-program-reporting-on-brca1-and-brca2-variant-interpretation-comparisons-through-the-canadian-open-genetics-repository-cogr
#2
Matthew S Lebo, Kathleen-Rose Zakoor, Kathy Chun, Marsha D Speevak, John S Waye, Elizabeth McCready, Jillian S Parboosingh, Ryan E Lamont, Harriet Feilotter, Ian Bosdet, Tracy Tucker, Sean Young, Aly Karsan, George S Charames, Ronald Agatep, Elizabeth L Spriggs, Caitlin Chisholm, Nasim Vasli, Hussein Daoud, Olga Jarinova, Robert Tomaszewski, Stacey Hume, Sherryl Taylor, Mohammad R Akbari, Jordan Lerner-Ellis
PurposeThe purpose of this study was to develop a national program for Canadian diagnostic laboratories to compare DNA-variant interpretations and resolve discordant-variant classifications using the BRCA1 and BRCA2 genes as a case study.MethodsBRCA1 and BRCA2 variant data were uploaded and shared through the Canadian Open Genetics Repository (COGR; http://www.opengenetics.ca). A total of 5,554 variant observations were submitted; classification differences were identified and comparison reports were sent to participating laboratories...
July 20, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28720311/evaluation-of-changes-in-blood-flow-of-the-uterine-artery-by-doppler-ultrasonography-during-the-estrous-cycle-in-lactating-bos-indicus-cows
#3
Mubbashar Hassan, Abdul Sattar, Muhammad Bilal, Muhammad Avais, Nasim Ahmad
The objective of this study was to evaluate the changes in uterine blood flow (UBF) based on the resistance index (RI) and the pulsatility index (PI) by Doppler ultrasonography throughout the estrous cycle in lactating Sahiwal cows (n=9). Cows were randomly selected during their spontaneous estrus. UBF was examined on alternate days in all cows during the estrous cycle. The results revealed that the mean RI values were higher (P<0.05) on day -1 (estrus) than on day 0 (ovulation). The mean RI values followed a consistent pattern on days 2, 4, 6, and 8 (metestrus to early diestrus) and were lower (P<0...
July 9, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28717373/diagnostic-value-of-alarm-symptoms-for-upper-gi-malignancy-in-patients-referred-to-gi-clinic-a-7-years-cross-sectional-study
#4
Mohammad Hasan Emami, Masoud Ataie-Khorasgani, Nasim Jafari-Pozve
BACKGROUND: Early upper gastrointestinal (UGI) cancer detection had led to organ-preserving endoscopic therapy. Endoscopy is a suitable method of early diagnosis of UGI malignancies. In Iran, exclusion of malignancy is the most important indication for endoscopy. This study is designed to see whether using alarm symptoms can predict the risk of cancer in patients. MATERIALS AND METHODS: A total of 3414 patients referred to a tertiary gastrointestinal (GI) clinic in Isfahan, Iran, from 2009 to 2016 with dyspepsia, gastroesophageal reflux disease (GERD), and alarm symptoms, such as weight loss, dysphagia, GI bleeding, vomiting, positive familial history for cancer, and anorexia...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28714119/high-performance-polymers-sandwiched-with-chemical-vapor-deposited-hexagonal-boron-nitrides-as-scalable-high-temperature-dielectric-materials
#5
Amin Azizi, Matthew R Gadinski, Qi Li, Mohammed Abu AlSaud, Jianjun Wang, Yi Wang, Bo Wang, Feihua Liu, Long-Qing Chen, Nasim Alem, Qing Wang
Polymer dielectrics are the preferred materials of choice for power electronics and pulsed power applications. However, their relatively low operating temperatures significantly limit their uses in harsh-environment energy storage devices, e.g., automobile and aerospace power systems. Herein, hexagonal boron nitride (h-BN) films are prepared from chemical vapor deposition (CVD) and readily transferred onto polyetherimide (PEI) films. Greatly improved performance in terms of discharged energy density and charge-discharge efficiency is achieved in the PEI sandwiched with CVD-grown h-BN films at elevated temperatures when compared to neat PEI films and other high-temperature polymer and nanocomposite dielectrics...
July 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28713687/group-psychological-intervention-for-maternal-depression-a-nested-qualitative-study-from-karachi-pakistan
#6
Nusrat Husain, Nasim Chaudhry, Christine Furber, Hina Fayyaz, Tayyeba Kiran, Farah Lunat, Raza Ur Rahman, Saira Farhan, Batool Fatima
AIM: To understand the experience of maternal depression, the factors implicated in accessing health, and the acceptability of the psychosocial intervention. METHODS: The participants were recruited from the paediatrics outpatient department of Civil Hospital Karachi, Pakistan. The study started in December 2009 and completed in December 2010. Women with maternal depression, aged 18-44 years with children aged 0-30 mo who had received nutritional supplements, and participated in the intervention programme [called Learning through Play (LTP) plus] were included in the study...
June 22, 2017: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28708475/prevalence-and-length-of-the-anterior-loop-of-the-inferior-alveolar-nerve-in-iranians
#7
Mahsa Shariati, Maryam Rastegar Moghddam, Zeinab Davoudmanesh, Nasim Azizi, Vahid Rakhshan
The anterior loop of the inferior alveolar nerve is a sensitive anatomical feature which should be taken into account during installing dental implants anterior to the mental foramen. Since results regarding its prevalence and length are controversial, this study was conducted. A total of 452 mandible quadrants of 234 patients (age: 50.1±13.3 years, 113 males, 121 females) were studied using cone-beam computerized tomography (CBCT). After reconstructing axial, frontal, and sagittal slices, the region between the most anterior point on the mental foramen and the most anterior part of the mandibular nerve was inspected for signs of anterior loop presence...
July 14, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28708432/epigenetic-changes-of-the-esr1-gene-in-breast-tissue-of-healthy-women-a-missing-link-with-breast-cancer-risk-factors
#8
Abdolreza Daraei, Pantea Izadi, Ghasemali Khorasani, Nahid Nafissi, Mohammad Mehdi Naghizadeh, Nasim Younosi, Alipasha Meysamie, Yaser Mansoori, Milad Bastami, Javad Tavakkoly-Bazzaz
BACKGROUND: Reproductive history and obesity are among the well-recognized risk factors in the development of breast cancer, which are partially mediated by the increased exposure of breast tissues to estrogens. However, only a few studies have investigated the link between these risk factors and the pattern of methylation signatures in the breast tissue of healthy women. The role of estrogen receptor 1 (ESR1) gene hypermethylation is reportedly important in the development of breast cancer...
July 14, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28706884/cytotoxic-evaluation-of-some-fused-pyridazino-and-pyrrolo-quinazolinones-derivatives-on-melanoma-and-prostate-cell-lines
#9
Golnaz Vaseghi, Elham Jafari, Farshid Hassanzadeh, Shaghayegh Haghjooy-Javanmard, Nasim Dana, Mahmoud Rafieian-Kopaei
BACKGROUND: Quinazolinon as an important class of heterocycles is attractive in medicinal research areas due to their wide range of biological effects. Cytotoxic activities of the quinazolinone derivatives in various cell lines including: HeLa, L1210 (mouse lymphocytic leukemia) and HT29 (human colon adenocarcinoma) were reported. MATERIALS AND METHODS: In this study, a number of newly made tricycles quinazolinone derivatives such as fused pyridazino-quinazolinones and fused pyrrolo-quinazolinones were evaluated on two cancerous cell lines, melanoma (B16F10) and prostate (PC3) using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide colorimetric assay...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28706531/crop-production-under-drought-and-heat-stress-plant-responses-and-management-options
#10
REVIEW
Shah Fahad, Ali A Bajwa, Usman Nazir, Shakeel A Anjum, Ayesha Farooq, Ali Zohaib, Sehrish Sadia, Wajid Nasim, Steve Adkins, Shah Saud, Muhammad Z Ihsan, Hesham Alharby, Chao Wu, Depeng Wang, Jianliang Huang
Abiotic stresses are one of the major constraints to crop production and food security worldwide. The situation has aggravated due to the drastic and rapid changes in global climate. Heat and drought are undoubtedly the two most important stresses having huge impact on growth and productivity of the crops. It is very important to understand the physiological, biochemical, and ecological interventions related to these stresses for better management. A wide range of plant responses to these stresses could be generalized into morphological, physiological, and biochemical responses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28703931/rationale-and-design-of-a-randomized-trial-of-apixaban-vs-warfarin-to-evaluate-atherosclerotic-calcification-and-vulnerable-plaque-progression
#11
Kazuhiro Osawa, Rine Nakanishi, Theingi Tiffany Win, Dong Li, Sina Rahmani, Negin Nezarat, Nasim Sheidaee, Matthew J Budoff
Vitamin K antagonists (VKAs) are known to increase vascular calcification, suggesting increased cardiovascular disease events. Apixaban is an oral direct factor Xa inhibitor superior to warfarin at preventing stroke or systemic embolism and may stabilize coronary atherosclerosis. The potential benefits of avoiding VKA therapy and the favorable effects of factor Xa inhibitors could contribute to cardiovascular disease event reduction. We hypothesized that apixaban inhibits vascular calcification and coronary atherosclerosis progression compared with warfarin in patients with atrial fibrillation (AF)...
July 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28702926/the-stability-evaluation-of-mesenchymal-stem-cells-differentiation-toward-endothelial-cells-by-chemical-and-mechanical-stimulation
#12
Elham Hasanzadeh, Ghassem Amoabediny, Nooshin Haghighipour, Nasim Gholami, Javad Mohammadnejad, Shahrokh Shojaei, Nasim Salehi-Nik
Adipose-derived mesenchymal stem cells (ADSCs) are adult multipotent cells able to differentiate into several cell lineages. Vascular endothelial growth factor (VEGF) and the shear stress associated with blood flow are considered as the most important chemical and mechanical cues that play major roles in endothelial differentiation. However, the stability of endothelial-specific gene expression has not been completely addressed yet. ADSCs in passage 3 were cultured inside the tubular silicon tubes and then exposed to VEGF or shear stress produced in a perfusion bioreactor...
July 12, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28699781/application-of-bacillus-megaterium-mcr-8-improved-phytoextraction-and-stress-alleviation-of-nickel-in-vinca-rosea
#13
Waheed Ullah Khan, Sajid Rashid Ahmad, Nasim Ahmad Yasin, Aamir Ali, Aqeel Ahmad, Waheed Akram
The current research was performed to evaluate the effect of Bacillus megaterium MCR-8 on mitigation of nickel (Ni) stress in Vinca rosea grown on Ni-contaminated soil (50, 100, and 200 mg Ni kg(-1) soil). The treated plants exhibited reduced growth, biomass, gas exchange capacity, and chlorophyll (Chl) content under Ni stress. The inoculated plants growing in Ni-contaminated media exhibited relatively higher growth, total soluble protein, and proline contents. Similarly, bacterial inoculation improved the activity of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and ascorbate peroxidase (APX) under Ni stress...
September 2, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28697631/recent-advances-on-biomedical-applications-of-scaffolds-in-wound-healing-and-dermal-tissue-engineering
#14
Azizeh Rahmani Del Bakhshayesh, Nasim Annabi, Rovshan Khalilov, Abolfazl Akbarzadeh, Mohammad Samiei, Effat Alizadeh, Mohammadreza Alizadeh-Ghodsi, Soodabeh Davaran, Azadeh Montaseri
The tissue engineering field has developed in response to the shortcomings related to the replacement of the tissues lost to disease or trauma: donor tissue rejection, chronic inflammation and donor tissue shortages. The driving force behind the tissue engineering is to avoid the mentioned issues by creating the biological substitutes capable of replacing the damaged tissue. This is done by combining the scaffolds, cells and signals in order to create the living, physiological, three-dimensional tissues. A wide variety of skin substitutes are used in the treatment of full-thickness injuries...
July 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28697469/differential-expression-of-curs-gene-during-various-growth-stages-climatic-condition-and-soil-nutrients-in-turmeric-curcuma-longa-towards-site-specific-cultivation-for-high-curcumin-yield
#15
I Sriram Sandeep, Suryasnata Das, Noohi Nasim, Antaryami Mishra, Laxmikanta Acharya, Raj Kumar Joshi, Sanghamitra Nayak, Sujata Mohanty
Curcuma longa L., accumulates substantial amount of curcumin and essential oil. Little is known about the differential expression of curcumin synthase (CURS) gene and consequent curcumin content variations at different agroclimatic zones. The present study aimed to evaluate the effect of climate, soil and harvesting phase on expression of CURS gene for curcumin yield in two high yielding turmeric cultivars. Expression of CURS gene at different experimental zones as well as at different harvesting phase was studied through transcriptional analysis by qRT-PCR...
July 4, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28690472/lung-adenocarcinoma-with-miliary-metastases-and-left-femur-pathologic-fracture-an-unusual-case-mimicking-disseminated-tuberculosis
#16
Nasim Khadem, Cristina Costales, Eric A White, Dakshesh B Patel, Anderanik Tomasian, George R Matcuk
No abstract text is available yet for this article.
July 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28685322/affected-female-carriers-of-mtm1-mutations-display-a-wide-spectrum-of-clinical-and-pathological-involvement-delineating-diagnostic-clues
#17
Valérie Biancalana, Sophie Scheidecker, Marguerite Miguet, Annie Laquerrière, Norma B Romero, Tanya Stojkovic, Osorio Abath Neto, Sandra Mercier, Nicol Voermans, Laura Tanner, Curtis Rogers, Elisabeth Ollagnon-Roman, Helen Roper, Célia Boutte, Shay Ben-Shachar, Xavière Lornage, Nasim Vasli, Elise Schaefer, Pascal Laforet, Jean Pouget, Alexandre Moerman, Laurent Pasquier, Pascale Marcorelle, Armelle Magot, Benno Küsters, Nathalie Streichenberger, Christine Tranchant, Nicolas Dondaine, Raphael Schneider, Claire Gasnier, Nadège Calmels, Valérie Kremer, Karine Nguyen, Julie Perrier, Erik Jan Kamsteeg, Pierre Carlier, Robert-Yves Carlier, Julie Thompson, Anne Boland, Jean-François Deleuze, Michel Fardeau, Edmar Zanoteli, Bruno Eymard, Jocelyn Laporte
X-linked myotubular myopathy (XLMTM), a severe congenital myopathy, is caused by mutations in the MTM1 gene located on the X chromosome. A majority of affected males die in the early postnatal period, whereas female carriers are believed to be usually asymptomatic. Nevertheless, several affected females have been reported. To assess the phenotypic and pathological spectra of carrier females and to delineate diagnostic clues, we characterized 17 new unrelated affected females and performed a detailed comparison with previously reported cases at the clinical, muscle imaging, histological, ultrastructural and molecular levels...
July 6, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28684374/investigating-crispr-cas-systems-in-clostridium-botulinum-via-bioinformatics-tools
#18
Manica Negahdaripour, Navid Nezafat, Nasim Hajighahramani, Seyyed Soheil Rahmatabadi, Younes Ghasemi
The Clustered regularly interspaced short palindromic repeats (CRISPR) systems are a type of innate immunity found in some prokaryotes, which protect them against alien genetic elements by targeting foreign nucleic acids. Some other functions are also attributed to these systems. Clostridium botulinum bacteria produce botulinum neurotoxins (BoNT), one of the deadliest known toxins for humans and some animals. Food poisoning due to these bacteria is still a challenge in food industries. On the other hand, BoNT has been widely investigated for therapeutic applications including different muscle disorders...
July 3, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28661987/upper-gastrointestinal-endoscopic-evaluation-following-household-sodium-hypochlorite-ingestion
#19
Shahriar Nikpour, Elnaz Masoumi-Moghaddam, Soha Pazoki, Hossein Hassanian-Moghaddam, Nasim Zamani
Endoscopy is generally speculated to be unnecessary in sodium hypochlorite (NaClO) ingestions; however, a significant number of endoscopic evaluations are still being performed when this chemical is ingested. Therefore, the aim of the current study was to compare the outcome and endoscopic findings between patients who had ingested household NaClO and those who had ingested other types of corrosives. This retrospective cohort study enrolled 137 patients with a history of corrosive substance ingestion admitted to a tertiary hospital...
June 28, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28660962/reinforcement-of-natural-rubber-latex-using-lignocellulosic-nanofibers-isolated-from-spinifex-grass
#20
Alireza Hosseinmardi, Pratheep K Annamalai, Lianzhou Wang, Darren Martin, Nasim Amiralian
Reinforcement of natural rubber (NR) using nanofillers often results in an enhancement of the tensile strength, but at the expense of elongation at break and toughness. In this study, with the objective of strengthening NR without compromising its compliance, we investigate the reinforcement efficiency of a series of cellulose nanofibers (CNF) with variations in residual hemicellulose, lignin and therefore surface chemistry. Different types of high aspect ratio CNF isolated from Triodia pungens (T. pungens), an Australian arid grass commonly known as spinifex, were added at 0...
July 13, 2017: Nanoscale
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