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Muhammad Usman Mehmood, Ahmad Qamar, Abdul Sattar, Liaquat Ahmad, Nasim Ahmad
The present study was designed to determine the effect of estradiol benzoate (EB) on reproductive response following a controlled internal drug release (CIDR) protocol in crossbred (Sahiwal × Friesian) dairy heifers. In the first trial, a total of 100 crossbred dairy heifers were treated with CIDR protocol for 7 days and injected with the PGF2α on day 6. After 24 h of CIDR removal, one group (EB = 50) was injected with estradiol benzoate whereas the other (control = 50) remained untreated. Estrus intensity and response were recorded visually and ovulation rate was recorded by ultrasonography...
December 2, 2016: Tropical Animal Health and Production
Ronica H Nanda, Bahig M Shehata, Nasim Khoshnam, Megan Durham, Sungjin Kim, Wasim Selwanes, Zhengjia Chen, Chao Zhang, Natia Esiashvili
It is unclear if lymph node sampling in Wilms tumour, though critical for staging purposes, affects survival outcomes. The value of lymph node sampling in patients treated with neoadjuvant chemotherapy (NAC) is even more uncertain. We reviewed our institutional data to determine the impact of lymph node sampling on survival, as well as its role in the context of NAC. A total of 185 patients with Wilms tumour treated at our institution were included in this analysis. The number of nodes sampled (≤7, or >7), lymph node status (unknown, negative, or positive), pathological stage, and use of neoadjuvant chemotherapy were analysed for survival outcomes...
November 29, 2016: Pathology
Louise Mc Grath-Lone, Lorraine Dearden, Katie Harron, Bilal Nasim, Ruth Gilbert
Exiting and re-entering out-of-home care (OHC) is considered a disruption to permanence which may have long-lasting, negative consequences for children due to a lack of stability and continuity. Each year approximately one-third of children in OHC in England exit, but information is lacking on rates of re-entries and associated factors. Using national administrative data, we calculated rates of re-entry among children exiting OHC from 2007 to 2012, identified key child and care factors associated with re-entry using Cox proportional hazards modelling, and developed a simple probability calculator to estimate which groups of children are most likely to re-enter OHC within three months...
November 28, 2016: Child Abuse & Neglect
Hossein Hassanian-Moghaddam, Nasim Zamani
The information on burden of alcohol abuse in Iran is scarce. However, the available data show that mortality rates and frequency of its use have increased in the Iranian community. In particular, Iran occupies the 1st rank in the number of outbreak incidents and victims of toxic alcohols such as methanol in the Middle East. Mortality and morbidity of toxic alcohols are high if prompt diagnosis and treatment are not initiated rapidly. On-time diagnosis, proper case finding, and standard treatment have an essential role to reduce mortality and morbidity of toxic alcohols particularly blindness and other physical and psychological disabilities...
November 2016: Iranian Journal of Kidney Diseases
Nasim Gorji, Aprile L Pilon, Melissa E Winn, Morgan Newsome, Jonathan M Davis
BACKGROUND: The club cell 10-kDa protein (CC10) is a homeostatic protein that is produced in the lung, diffuses into the blood, and is then excreted into the urine and stool. CC10 is known to have anti-inflammatory properties and to have lower endogenous production in preterm infants. OBJECTIVES: As recombinant human CC10 (rhCC10) is being studied in preterm infants to reduce lung injury, understanding CC10 levels in term infants with normal lungs is needed to establish appropriate target dosing ranges...
December 1, 2016: Neonatology
Mohammed A Al-Qarni, Nasim Vahid Shakeela, Mohammed Abdullah Alamri, Yahya A Alshaikh
INTRODUCTION: Eco-friendly or green dentistry can be a reality by effectively designing dental clinics and using more eco-friendly materials in the clinical practice. AIM: To determine the awareness of eco-friendly dentistry among dental faculty and students in preparation for future implementation. MATERIALS AND METHODS: Assessment of knowledge regarding eco-friendly dentistry was done using an 18 item self-administered questionnaire among 160 participants...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
Nasim Zamani, Hossein Hassanian-Moghaddam, Masoud Latifi
No abstract text is available yet for this article.
November 24, 2016: Gastroenterology
Jelena M Pavlovic, Didem Akcali, Hayrunnisa Bolay, Carolyn Bernstein, Nasim Maleki
Migraine is a common neurological disorder with significantly higher incidence and prevalence in women than men. The presentation of the disease in women is modulated by changes in sex hormones from adolescence to pregnancy and menopause. Yet, the effect of sex influences has often been neglected in both basic and clinical and in clinical management of the disease. In this review, evidence from epidemiological, clinical, animal, and neuroimaging studies on the significance of the sex-related influences in migraine is presented, and the unmet needs in each area are discussed...
January 2, 2017: Journal of Neuroscience Research
Nasim Samandari, Aashiq H Mirza, Lotte B Nielsen, Simranjeet Kaur, Philip Hougaard, Siri Fredheim, Henrik B Mortensen, Flemming Pociot
AIMS/HYPOTHESIS: We aimed to identify circulating microRNA (miRNA) that predicts clinical progression in a cohort of 123 children with new-onset type 1 diabetes mellitus. METHODS: Plasma samples were prospectively obtained at 1, 3, 6, 12 and 60 months after diagnosis from a subset of 40 children from the Danish Remission Phase Cohort, and profiled for miRNAs. At the same time points, meal-stimulated C-peptide and HbA1c levels were measured and insulin-dose adjusted HbA1c (IDAA1c) calculated...
November 19, 2016: Diabetologia
Jan Jamroskovic, Madeleine Livendahl, Jonas Eriksson, Erik Chorell, Nasim Sabouri
Small molecules are used in the G-quadruplex (G4) research field in vivo and in vitro, and there are increasing demands for ligands that selectively stabilize different G4 structures. Thioflavin T (ThT) emits an enhanced fluorescence signal when binding to G4 structures. Herein, we show that ThT can be competitively displaced by the binding of small molecules to G4 structures and develop a ThT-displacement high-throughput screening assay to find novel and selective G4-binding compounds. We screened approximately 28 000 compounds by using three different G4 structures and identified eight novel G4 binders...
November 15, 2016: Chemistry: a European Journal
Thomas K Berger, David M Fußhöller, Normann Goodwin, Wolfgang Bönigk, Astrid Müller, Nasim Dokani Khesroshahi, Christoph Brenker, Dagmar Wachten, Eberhard Krause, U Benjamin Kaupp, Timo Strünker
In human sperm, the voltage-gated proton channel Hv1 controls the flux of protons across the flagellar membrane. Here, we show that sperm harbor Hv1 and a shorter isoform, termed Hv1Sper. Hv1Sper is generated from Hv1 by removal of 68 amino acids from the N-terminus by posttranslational proteolytic cleavage. The pH-dependent gating of the channel isoforms is distinctly different. In both Hv1 and Hv1Sper, the conductance-voltage relationship is determined by the pH difference across the membrane (∆pH). However, simultaneous changes in intracellular and extracellular pH that leave ΔpH constant strongly shift the activation curve of Hv1Sper, but not that of Hv1, demonstrating that cleavage of the N-terminus tunes pH sensing in Hv1...
November 17, 2016: Journal of Physiology
Mansoreh Mirzaie, Esmael Yassini, Ardavan Etemadi, Atefeh Tavakoli, Nasim Chiniforush
Purpose: This study evaluated the micro-tensile bond strength of new and previous composite resin restorations after surface treatment with diamond bur and Er,Cr:YSGG laser at different power settings (2,3 and 4 W). Materials and methods: Micro-hybride composite resin was inserted in metallic mold 5 ×5 ×15 mm and cured for 40 sec according to manufacturer's instruction.12 blocks were made. The bonded surfaces of the 12 blocks so obtained were subsequently ground using Silicon Carbide papers 1200 grit, for 15 seconds under running water...
October 1, 2016: Laser Therapy
Nasim Babaknejad, Fatemeh Sayehmiri, Kourosh Sayehmiri, Ashraf Mohamadkhani, Somaye Bahrami
OBJECTIVE: Autism is a complex behaviorally defined disorder.There is a relationship between zinc (Zn) levels in autistic patients and development of pathogenesis, but the conclusion is not permanent. MATERIALS & METHODS: The present study conducted to estimate this probability using meta-analysis method. In this study, Fixed Effect Model, twelve articles published from 1978 to 2012 were selected by searching Google scholar, PubMed, ISI Web of Science, and Scopus and information were analyzed...
2016: Iranian Journal of Child Neurology
Md Moshfekus Saleh-E-In, Nasim Sultana, Md Nur Hossain, Sayeema Hasan, Md Rabiul Islam
BACKGROUND: Anethum sowa L. is widely used as an important spice and traditional medicinal plants to treat various ailments. On the basis of scientific ethnobotanical information, this study was undertaken to evaluate the antioxidant, antimicrobial and cytotoxic activity of the crude extracts of Anethum sowa L. roots as well as to identify the classes of phytochemicals by chemical tests. METHODS: The antioxidant potential of the extracts was ascertained with the stable organic free radical (2, 2-diphenyl-1-picryl-hydrazyl)...
November 14, 2016: BMC Complementary and Alternative Medicine
Parvin Safavi, Ali Hasanpour Dehkordi, Nasim Ghasemi
Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric disorder among preschool children but the number of controlled clinical trials regarding psychopharmacological treatment in this age group is limited. The aim of this study was to compare methylphenidate with the combination of methylphenidate and risperidone in preschool children with ADHD. Forty-two preschool children, aged 3-6 years, diagnosed with ADHD by a child and adolescent psychiatrist according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-Text Revision criteria, were enrolled in a 6-week, single-blind clinical trial and administered with methylphenidate (5-30 mg/dl) or the combination of methylphenidate and risperidone (0...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
Zeinab Vahidinia, Nasim Alipour, Mohammad Ali Atlasi, Homayoun Naderian, Cordian Beyer, Abolfazl Azami Tameh
OBJECTIVES: Apoptosis plays an important role in the progression of the ischemic penumbra after reperfusion. Estrogen and progesterone have neuroprotective effects against ischemic brain damage, however the exact mechanisms of neuroprotection and signaling pathways is not completely understood. In this study, we investigated the possible regulatory effects of a combined steroid treatment on extrinsic and intrinsic apoptotic signaling pathways after cerebral ischemia. METHODS: Adult male Wistar rats were subjected to transient middle cerebral artery occlusion (tMCAO) using an intraluminal filament technique for 1 h followed by 23 h reperfusion...
November 11, 2016: Neurological Research
Hafiz Mohkum Hammad, Wajid Farhad, Farhat Abbas, Shah Fahad, Shafqat Saeed, Wajid Nasim, Hafiz Faiq Bakhat
Knowledge of the dynamics of plant nitrogen (N) uptake at varying irrigation water levels is critical for strategizing increased N recovery efficiency (NRE), water use efficiency (WUE), and maize yield. The N dynamics were studied under various irrigation regimes to evaluate NRE, WUE, and maize yield. A pot experiment was conducted using three irrigation water regimes (50, 75, and 100% field capacity (FC)) and four N fertilizer rates (0, 1.6, 3.2, and 4.8 g pot(-1)) applied with two fertilizer application methods including foliar and soil applications...
November 8, 2016: Environmental Science and Pollution Research International
Xin Zhao, Xiaoming Sun, Lara Yildirimer, Qi Lang, Zhi Yuan William Lin, Reila Zheng, Yuguang Zhang, Wenguo Cui, Nasim Annabi, Ali Khademhosseini
: Development of natural protein-based fibrous scaffolds with tunable physical properties and biocompatibility is highly desirable to construct a three-dimensional (3D), fully cellularized scaffold for wound healing. Herein, we demonstrated a simple and effective technique to construct electrospun 3D fibrous scaffolds for accelerated wound healing using a photocrosslinkable hydrogel based on methacryloylated gelatin (GelMA). We found that the physical properties of the photocrosslinkable hydrogel including water retention, stiffness, strength, elasticity and degradation can be tailored by changing the light exposure time...
November 4, 2016: Acta Biomaterialia
Jing Hu, Alireza Khodadadi-Jamayran, Miaowei Mao, Kushani Shah, Zhenhua Yang, Md Talat Nasim, Zefeng Wang, Hao Jiang
Alternative splicing of pre-mRNAs significantly contributes to the complexity of gene expression in higher organisms, but the regulation of the splice site selection remains incompletely understood. We have previously demonstrated that a chromatin-associated protein, AKAP95, has a remarkable activity in enhancing chromatin transcription. In this study, we show that AKAP95 interacts with many factors involved in transcription and RNA processing, including selective groups of hnRNP proteins, through its N-terminal region, and directly regulates pre-mRNA splicing...
November 8, 2016: Nature Communications
Waheed Ullah Khan, Sajid Rashid Ahmad, Nasim Ahmad Yasin, Aamir Ali, Aqeel Ahmad
The remediation of heavy metal contaminated soils has become a critical issue due to toxic effects of these metals on living organisms. The current research was conducted to study the effect of Pseudomonas fluorescens RB4 and Bacillus subtilis 189 on the growth and phytoremediation potential of Catharanthus roseus in Cu and Pb contaminated soils. The bacterial strains exhibited significantly higher level of water extractable Pb and Cu in Pb, Cu and both elements contaminated soils. The P. fluorescens RB4 inoculated plants, produced 102%, 48% and 45% higher fresh weight (FW) in soils contaminated with Cu, Pb and both elements respectively, as compared to un-inoculated control plants...
November 7, 2016: International Journal of Phytoremediation
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