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Glomerulonephritis.

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https://www.readbyqxmd.com/read/29907458/taci-deletion-protects-against-progressive-murine-lupus-nephritis-induced-by-baff-overexpression
#1
Tanvi Arkatkar, Holly M Jacobs, Samuel W Du, Quan-Zhen Li, Kelly L Hudkins, Charles E Alpers, David J Rawlings, Shaun W Jackson
B cells are known to promote the pathogenesis of systemic lupus erythematosus (SLE) via the production of pathogenic anti-nuclear antibodies. However, the signals required for autoreactive B cell activation and the immune mechanisms whereby B cells impact lupus nephritis pathology remain poorly understood. The B cell survival cytokine B cell activating factor of the TNF Family (BAFF) has been implicated in the pathogenesis of SLE and lupus nephritis in both animal models and human clinical studies. Although the BAFF receptor has been predicted to be the primary BAFF family receptor responsible for BAFF-driven humoral autoimmunity, in the current study we identify a critical role for signals downstream of Transmembrane Activator and CAML Interactor (TACI) in BAFF-dependent lupus nephritis...
June 12, 2018: Kidney International
https://www.readbyqxmd.com/read/29907095/a-case-of-immunotactoid-glomerulopathy-with-false-negative-igg-staining
#2
Shuma Hirashio, Takahiro Arima, Ayaka Satoh, Kouichi Mandai, Shigeo Hara, Takao Masaki
BACKGROUND: Immunotactoid glomerulopathy (ITG) is a rare glomerulonephritis characterized by microtubular deposits. Immunofluorescence findings are necessary to differentiate ITG from other proliferative glomerular diseases. The characteristic tubular structure on electron microscopy is essential for a definitive diagnosis, and the diameter of the structure has been traditionally used for differentiating between ITG and other types of glomerulonephritis with organized deposits. In recent years, the disease concept of monoclonal gammopathy of renal significance, which is associated with M protein produced by plasma cell tumors, has been proposed...
June 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29906312/successful-treatment-of-chronic-hepatitis-c-infection-with-crushed-elbasvir-grazoprevir-administered-via-a-percutaneous-endoscopic-gastrostomy-tube
#3
J E Yap, P Jaiswal, L Ton, R Szynkarek, B M Attar, S Gandhi
WHAT IS KNOWN AND OBJECTIVE: Elbasvir/grazoprevir is an all-oral regimen approved for patients with hepatitis C virus (HCV) genotypes 1 and 4, and in renal insufficiency. However, to date, no data exist on the efficacy of this regimen when it is crushed and administered through a percutaneous endoscopic gastrostomy (PEG) tube. Here, we illustrate the case of a 63-year-old man who is the only known patient with HCV infection in the English literature to have successfully achieved a sustained viral response (SVR) when elbasvir/grazoprevir oral combination was administered through a PEG tube...
June 15, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29906252/pembrolizumab-for-patients-with-refractory-or-relapsed-thymic-epithelial-tumor-an-open-label-phase-ii-trial
#4
Jinhyun Cho, Hae Su Kim, Bo Mi Ku, Yoon-La Choi, Razvan Cristescu, Joungho Han, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
Purpose Limited treatment options exist for patients with thymic epithelial tumor (TET) whose disease progresses after platinum-based chemotherapy. We conducted a phase II study of pembrolizumab in patients with TET to evaluate its efficacy and safety. Methods Patients with histologically confirmed TET whose disease progressed after at least one line of platinum-based chemotherapy were eligible for the study. Patients were excluded if they had an active autoimmune disease requiring systemic treatment within the past year or documented history of clinically severe autoimmune disease...
June 15, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29905852/omics-studies-for-comprehensive-understanding-of-immunoglobulin-a-nephropathy-state-of-the-art-and-future-directions
#5
Francesco Paolo Schena, Grazia Serino, Fabio Sallustio, Mario Falchi, Sharon N Cox
Immunoglobulin A nephropathy (IgAN) is the most common worldwide primary glomerulonephritis with a strong autoimmune component. The disease shows variability in both clinical phenotypes and endpoints and can be potentially subdivided into more homogeneous subtypes through the identification of specific molecular biomarkers. This review focuses on the role of omics in driving the identification of potential molecular subtypes of the disease through the integration of multilevel data from genomics, transcriptomics, epigenomics, proteomics and metabolomics...
June 13, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29905555/goodpascher-s-syndrome-the-challenges-in-a-timely-diagnosis-and-treatment-in-medical-practice-clinical-case
#6
V Talash, T Bevzenko, T Yarmola, L Tkachenko, H Pustovoyt
The article presents a clinical case with intravital diagnosis of Goodpascher's syndrome in a 22 years old patient. In this work we analyze clinical, laboratory-instrumental, pathologoanatomic and pathomorphological aspects of the disease, which was accompanied by glomerulonephritis with rapidly progressive renal insufficiency, anemia, arterial hypertension and symptoms of lung injury. Article emphasizes on the necessity of timely diagnosis of Goodpascher's syndrome and following administration of immunosuppressive therapy...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904727/retreatment-of-symptomatic-hepatitis-c-virus-genotype-3-associated-mixed-cryoglobulinemia-with-sofosbuvir-and-ribavirin-a-case-report
#7
Dorota Zarębska-Michaluk, Piotr M Stępień, Katarzyna Paluch, Paweł Pabjan
A 52-year-old woman with chronic hepatitis C virus genotype 3 infection developed clinically symptomatic mixed cryoglobulinemia. She started pegylated interferon and ribavirin therapy and in week 12 became negative for HCV RNA with resolution of clinical signs of cryoglobulinemia. The dual treatment was discontinued due to interferon-related bilateral retinopathy. After therapy cessation, relapse of HCV RNA and recurrence of symptomatic cryoglobulinemia were observed. While waiting for the antiviral retreatment option she developed glomerulonephritis with renal impairment...
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29901607/membranoproliferative-glomerulonephritis-like-findings-for-tafro-syndrome-associated-with-an-anterior-mediastinal-tumor-a-case-report
#8
Yoshitaka Furuto, Hirotsugu Hashimoto, Hajime Horiuti, Yuko Shibuya
RATIONALE: TAFRO syndrome is a systemic inflammatory disease proposed recently from Japan. The cause of TAFRO syndrome is unclear. Moreover, the disease characteristics and kidney pathology are yet unknown well and there are few cases. Herein, we report a patient with TAFRO syndrome and present the features of the renal histopathology. PATIENT CONCERNS: A 55-year-old woman presented to our hospital with the main complaint of subacute dyspnoea. DIAGNOSIS: Physical findings included a low-grade fever and generalised oedema...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901005/pauci-immune-crescentic-glomerulonephritis-in-a-patient-with-immunoglobulin-a-nephropathy-and-serum-antineutrophil-cytoplasmic-autoantibody-positivity
#9
Keren Cohen-Hagai, Sydney Benchetrit, Osnat Klein, Yona Kitay-Cohen, Ze'ev Korzets
No abstract text is available yet for this article.
March 2018: Archives of Rheumatology
https://www.readbyqxmd.com/read/29900000/staphylococcus-associated-glomerulonephritis-mimicking-henoch-sch%C3%A3-nlein-purpura-and-cryoglobulinemic-vasculitis-in-a-patient-with-an-epidural-abscess-a-case-report-and-brief-review-of-the-literature
#10
Tahrin Mahmood, Robert Puckrin, Linda Sugar, David Naimark
Rationale: Staphylococcus-associated glomerulonephritis (SAGN) is a rare immune complex-mediated glomerulonephritis associated with active Staphylococcus infection. We report a case illustrating the importance of clinical history and kidney biopsy findings in establishing the correct diagnosis. Presenting concerns of the patient: We report the case of a 64-year-old man with alcohol-associated cirrhosis, type 2 diabetes mellitus, and hypertension who presented to hospital with lower back and abdominal pain, rectal bleeding, a purpuric lower extremity rash, and oliguric acute kidney injury with microscopic hematuria and nephrotic-range proteinuria...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29899355/long-term-outcomes-of-kidney-transplant-recipients-with-end-stage-kidney-disease-attributed-to-presumed-advanced-glomerulonephritis-or-unknown-cause
#11
Wai H Lim, Germaine Wong, Stephen P McDonald, Aron Chakera, Grant Luxton, Nicole M Isbel, Helen L Pilmore, Tom Barbour, Peter Hughes, Steven J Chadban
People with biopsy-proven glomerulonephritis (GN) as their cause of end-stage kidney disease (ESKD) who undergo kidney transplantation incur significant risk of recurrent GN-related graft failure, but the risk in recipients with ESKD where GN was suspected but not biopsy proven (presumed/advanced GN) and when the cause of ESKD is unknown remains uncertain. Using the Australia and New Zealand Dialysis and Transplant registry, we examined the associations between primary kidney transplant recipients whose ESKD was attributed to: 1) commonly-recurring GN (i...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29895432/targeted-inhibition-of-axl-receptor-tyrosine-kinase-ameliorates-anti-gbm-induced-lupus-like-nephritis
#12
Yuxuan Zhen, Iris J Lee, Fred D Finkelman, Wen-Hai Shao
Glomerulonephritis (GN) is a typical lesion in autoantibody and immune complex disorders, including SLE. Because the Gas6/Axl pathway has been implicated in the pathogenesis of many types of GN, targeting this pathway might ameliorate GN. Consequently, we have studied the efficacy and mechanism of R428, a potent selective Axl inhibitor, in the prevention of experimental anti-GBM nephritis. Axl upregulation was investigated with Sp1/3 siRNA in the SV40-transformed mesangial cells. For Axl inhibition, a daily dose of R428 (125 mg/kg) or vehicle was administered orally...
June 9, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29893433/the-1-year-renal-biopsy-index-1-rbi-a-scoring-system-to-drive-biopsy-indication-at-1-year-post-kidney-transplantation
#13
REVIEW
Magali Giral, Karine Renaudin, Maarten Naesens, Redmer Luning, Dany Anglicheau, Emmanuel Morelon, Alexandre Huneau, Chloé Paul, Sophie Brouard, Grégoire Couvrat-Desvergnes, Yohann Foucher, Etienne Dantan
Surveillance biopsies after renal transplantation remain debatable. To drive the decision of such intervention, we propose a predictive score of abnormal histology at 1-year post-transplantation, named 1-Year Renal Biopsy Index (1-RBI). We studied 466 kidney recipients from the DIVAT cohort alive with a functioning graft and a surveillance biopsy at 1-year post-transplantation. Patients displaying abnormal histology (49%) (borderline, acute rejection, IFTA grade 2 or 3, glomerulonephritis) were compared to the normal or subnormal (IFTA grade 1) histology group...
June 12, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29892304/essential-roles-for-mannose-binding-lectin-associated-serine-protease-1-3-in-the-development-of-lupus-like-glomerulonephritis-in-mrl-lpr-mice
#14
Takeshi Machida, Natsumi Sakamoto, Yumi Ishida, Minoru Takahashi, Teizo Fujita, Hideharu Sekine
The complement system, composed of the three activation pathways, has both protective and pathogenic roles in the development of systemic lupus erythematosus (or lupus), a prototypic autoimmune disease. The classical pathway contributes to the clearance of immune complexes (ICs) and apoptotic cells, whereas the alternative pathway (AP) exacerbates renal inflammation. The role of the lectin pathway (LP) in lupus has remained largely unknown. Mannose-binding lectin (MBL)-associated serine proteases (MASPs), which are associated with humoral pattern recognition molecules (MBL or ficolins), are the enzymatic constituents of the LP and AP...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29891261/-chronic-lymphoid-leukemia-and-renal-complication-report-on-10-cases-from-marseille-over-16-years
#15
R Vial, L Daniel, M Devos, B Bouchacourt, G Cazajous, H Sichez, K Mazodier, M Lankester, P Gobert, J Seguier, L Swiader, M Sallée, N Jourde-Chiche, J-R Harlé
INTRODUCTION: Chronic lymphoid leukemia (CLL) is a hematological malignant disease, associated with a clonal B cell proliferation. The incidence is 4400 new cases per year in France. The prevalence increases with age with a median age at diagnostic of 65 years. Renal involvement is rare and estimated at 1.2% of patients with CLL. Renal pathological diagnoses associated with CLL are variable and are not always related to the hematological disease. We report here on cases of patients with CLL who underwent a renal biopsy over the past 16 years in Marseille...
June 8, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29884135/c3-glomerulonephritis-associated-with-monoclonal-gammopathy-of-renal-significance-case-report
#16
Juana Alonso-Titos, Lara Perea-Ortega, Eugenia Sola, Alvaro Torres-Rueda, Myriam León, Remedios Toledo, Ana D Duarte, Teresa Vazquez, Maria Dolores Martinez-Esteban, Alicia Bailen, Pedro Ruiz-Esteban, Domingo Hernandez
BACKGROUND: Morbidity associated with monoclonal gammopathy of renal significance is high due to the severe renal lesions and the associated systemic alterations. Accordingly, early diagnosis is fundamental, as is stopping the clonal production of immunoglobulins using specific chemotherapy. CASE PRESENTATION: A 75-year-old man with chronic renal disease of unknown origin since 2010 experienced rapid worsening of renal function over a period of 6 mos. Bone marrow biopsy showed monoclonal gammopathy of undetermined significance...
June 8, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29882111/impact-of-high-mortality-in-incident-dialysis-patients-due-to-hypertensive-nephrosclerosis-a-multicenter-prospective-cohort-study-in-aichi-japan
#17
Daijo Inaguma, Eri Ito, Kazuo Takahashi, Hiroki Hayashi, Shigehisa Koide, Midori Hasegawa, Yukio Yuzawa
INTRODUCTION: An increasing number of patients worldwide require dialysis as a result of hypertensive nephrosclerosis (HTN). However, in Japan, mortality in patients with end-stage renal disease (ESRD) has not been well by primary kidney disease including HTN and diabetic nephropathy (DN). Hence, we examined the differences in mortality among the primary kidney diseases of incident dialysis patients. METHODS: The study was a multicenter prospective cohort analysis including 1520 incident dialysis patients in Aichi prefecture, Japan...
June 7, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29879319/induction-therapy-for-membranous-lupus-nephritis-a-systematic-review-and-network-meta-analysis
#18
REVIEW
Kuo-Tung Tang, Chien-Hua Tseng, Tsu-Yi Hsieh, Der-Yuan Chen
AIM: Membranous lupus glomerulonephritis (MLN) is associated with morbidities such as thromboembolism, peripheral edema and/or hyperlipidemia. However, treatment of MLN remains elusive. METHODS: We performed systematic searches on MEDLINE, EMBASE and Cochrane Library database up to November, 2017. Eligible studies included randomized trials or cohort studies which evaluated different immunosuppressants in adult patients with pathologically proved MLN. No language restrictions were applied...
June 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29879042/pulmonary-renal-syndrome-a-case-report-of-diffuse-alveolar-hemorrhage-in-association-with-anca-negative-pauci-immune-glomerulonephritis
#19
Lakshmi Saladi, Danial Shaikh, Muhammad Saad, Enny Cancio-Rodriguez, Vivette D D'Agati, Boris Medvedovsky, Kalpana A Uday, Muhammad Adrish
RATIONALE: Pulmonary renal syndrome (PRS) is a term most commonly used to describe a combination of glomerulonephritis and pulmonary hemorrhage as a manifestation of a multisystem autoimmune disease. It is usually associated with ANCA vasculitis and anti-GBM disease. Diffuse alveolar hemorrhage in a patient with ANCA and anti-GBM negative pauci-immune glomerulonephritis is rare and optimal management is unknown. PATIENT CONCERNS: An 85-year-old man with hypertension, diabetes mellitus, prostate cancer and recently diagnosed pauci-immune necrotizing glomerulonephritis presented to our emergency department with worsening dyspnea and pedal edema for several days...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29877285/successful-treatment-of-iga-vasculitis-complicated-with-bowel-perforation-and-crescentic-glomerulonephritis-by-combination-therapy-of-glucocorticoid-cyclosporine-and-factor-xiii-replacement
#20
Keiko Koshiba, Sei Muraoka, Toshihiro Nanki, Satoru Komatsumoto
We report the findings of an 18-year-old boy with immunoglobulin A vasculitis (IgAV) complicated with bowel perforation and nephritis. He presented with abdominal pain, arthralgia and palpable purpura. Massive proteinuria developed during his clinical course. The patient was treated successfully using combination therapy of glucocorticoid (GC), cyclosporine (CYA) and factor XIII (F XIII) replacement. A standard treatment strategy for severe IgAV patients has not been established due to its rarity. Combination therapy using GC, CYA and F XIII replacement should be considered for severe IgAV patients...
June 6, 2018: Internal Medicine
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