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https://www.readbyqxmd.com/read/28088240/feasibility-of-an-altruistic-sperm-donation-program-in-canada-results-from-a-population-based-model
#1
Daria O'Reilly, James M Bowen, Kuhan Perampaladas, Riaz Qureshi, Feng Xie, Edward Hughes
BACKGROUND: Stringent donor-screening criteria and legislation prohibiting payment for donor gametes have contributed to the radical decline of donor insemination (DI) using sperm provided by Canadian men. Thus, many individuals rely on imported sperm. This paper examines the feasibility of an altruistic sperm donation (ASD) program to meet the needs of Canadians. METHODS: Using Canadian census data, published literature and expert opinions, two population-based, top-down mathematical models were developed to estimate the supply and demand for donor sperm and the feasibility of an ASD program...
January 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28088177/a-novel-quantitative-pcr-detects-babesia-infection-in-patients-not-identified-by-currently-available-non-nucleic-acid-amplification-tests
#2
Lavoisier Akoolo, Samantha Schlachter, Rasel Khan, Laura Alter, Albert D Rojtman, Kristine Gedroic, Purnima Bhanot, Nikhat Parveen
BACKGROUND: Ticks transmit Babesia microti, the causative agents of babesiosis in North America and Europe. Babesiosis is now endemic in Northeastern USA and affects people of all ages. Babesia species infect erythrocytes and can be transmitted through blood transfusion. Whole blood and blood products, which are not tested for Babesia, can cause transfusion-transmitted babesiosis (TTB) resulting in severe consequences in the immuno-compromised patients. The purpose of this study was epidemiological evaluation of babesiosis in a tick-infested state...
January 14, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28088062/a-retrospective-audit-of-bacterial-culture-results-of-donated-human-milk-in-perth-western-australia
#3
Yahya Almutawif, Benjamin Hartmann, Megan Lloyd, Wendy Erber, Donna Geddes
INTRODUCTION: The bacterial content of donated human milk is either endogenous or introduced via contamination. Defining milk bank bacterial content will allow researchers to devise appropriate tests for significant and commonly encountered organisms. OBJECTIVE: A retrospective audit was conducted on data recorded from the Perron Rotary Express Milk Bank, King Edward Memorial Hospital, Subiaco, Western Australia. This aimed to describe the incidence of bacterial species detected in donated human milk and to identify potentially pathogenic bacteria...
January 11, 2017: Early Human Development
https://www.readbyqxmd.com/read/28087412/pain-prediction-by-serum-biomarkers-of-bone-turnover-in-people-with-knee-osteoarthritis-an-observational-study-of-tracp5b-and-cathepsin-k-in-oa
#4
Lilian N Nwosu, Maximilian Allen, Laura Wyatt, Janet L Huebner, Victoria Chapman, David A Walsh, Virginia B Kraus
OBJECTIVES: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K, indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). METHODS: Sera and clinical data were collected from 129 people (97 with 3-year follow-up) with knee OA from the Prediction of Osteoarthritis Progression (POP) cohort. Knee OA-related outcomes in POP included: WOMAC pain, NHANES I (pain, aching and stiffness), subchondral sclerosis, and radiographically determined tibiofemoral and patellofemoral OA...
January 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28087168/synthesis-structure-activity-relationships-studies-of-benzoxazinone-derivatives-as-%C3%AE-chymotrypsin-inhibitors
#5
Bishnu P Marasini, Fazal Rahim, Shahnaz Perveen, Aneela Karim, Khalid Mohammed Khan, Atta-Ur-Rahman, M Iqbal Choudhary
A series of benzoxazinones 1-28 were synthesized via reaction of anthranilic acid with various substituted benzoyl chlorides in the presence of triethylamine in chloroform. Compounds 1-18 showed a good inhibition of α-chymotrypsin with IC50±SEM values between 6.5 and 341.1μM. Preliminary structure-activity relationships studies indicated that the presence of substituents on benzene ring reduces the inhibitory potential of benzoxazinone. Also the increased inhibitory potential due to fluoro group at phenyl substituent was observed followed by chloro and bromo substituents...
January 4, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28081120/epidemiology-of-chikungunya-virus-outbreaks-in-guadeloupe-and-martinique-2014-an-observational-study-in-volunteer-blood-donors
#6
Pierre Gallian, Isabelle Leparc-Goffart, Pascale Richard, Françoise Maire, Olivier Flusin, Rachid Djoudi, Jacques Chiaroni, Remi Charrel, Pierre Tiberghien, Xavier de Lamballerie
BACKGROUND: During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, the virus dispersed to other Caribbean islands, continental America and many islands in the Pacific Ocean. Previous estimates of the attack rate were based on declaration of clinically suspected cases. METHODS/PRINCIPAL FINDINGS: Individual testing for CHIKV RNA of all (n = 16,386) blood donations between Feb-24th 2014 and Jan-31st 2015 identified 0·36% and 0·42% of positives in Guadeloupe and Martinique, respectively...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28080083/the-empathy-impulse-a-multinomial-model-of-intentional-and-unintentional-empathy-for-pain
#7
C Daryl Cameron, Victoria L Spring, Andrew R Todd
Empathy for pain is often described as automatic. Here, we used implicit measurement and multinomial modeling to formally quantify unintentional empathy for pain: empathy that occurs despite intentions to the contrary. We developed the pain identification task (PIT), a sequential priming task wherein participants judge the painfulness of target experiences while trying to avoid the influence of prime experiences. Using multinomial modeling, we distinguished 3 component processes underlying PIT performance: empathy toward target stimuli (Intentional Empathy), empathy toward prime stimuli (Unintentional Empathy), and bias to judge target stimuli as painful (Response Bias)...
January 12, 2017: Emotion
https://www.readbyqxmd.com/read/28079374/ultrafast-dynamics-of-hydrogen-bond-breaking-and-making-in-the-excited-state-of-fluoren-9-one-time-resolved-visible-pump-ir-probe-spectroscopic-study
#8
Rajib Ghosh, Aruna K Mora, Sukhendu Nath, Dipak K Palit
Fluoren-9-one (FL) molecule with a single hydrogen bond accepting site (C=O group) has been used as a probe for investigation of the dynamics of hydrogen bond in its lowest excited singlet (S1) state using subpicosecond time-resolved visible pump - IR probe spectroscopic technique. In hexafluoroisopropanol (HFIP), a strong hydrogen bond donating solvent, formation of FL-alcohol hydrogen bonded complex in the ground electronic (S0) state is nearly complete with negligible concentration of FL molecule remaining free in solution...
January 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28078667/philanthropy-in-health-professions-education-research-determinants-of-success
#9
Robert Paul, Elisa Hollenberg, Brian D Hodges
CONTEXT: Fund-raising is a new practice in medical education research. OBJECTIVES: This qualitative study explores a cross-sectional analysis of philanthropy in medical education in Canada and Europe and identifies some common characteristics in the fund-raising system, key roles and characteristics of research sites that have had success. METHODS: Medical education research sites that had received donations greater than Can$100 000 were identified by searching publicly available sources...
January 11, 2017: Medical Education
https://www.readbyqxmd.com/read/28077504/influence-of-history-of-cannabis-smoking-in-selected-donors-on-the-outcomes-of-lung-transplantation
#10
Prashant N Mohite, Mohamed Zeriouh, Diana G Sáez, Aron-Frederik Popov, Anton Sabashnikov, Bartlomiej Zych, Ashok Padukone, Levente Fazekas, Olga Ananiadou, Fabio De Robertis, Simona Soresi, Anna Reed, Martin Carby, André R Simon
OBJECTIVES: Cannabis is the most commonly abused illicit drug and the smokers are at the risk of lung infections, bullous emphysema and lung cancer. However, no evidence about the outcomes of lung transplantation (LTx) utilizing the lungs from such donors is available in the literature. METHODS: We retrospectively analysed lung 'organ offers' and LTx at our centre between January 2007 and November 2013. The outcomes of LTx utilizing lungs from donors with a history of cannabis smoking were compared with the outcomes of those with no such history using unadjusted model as well as propensity score matching...
January 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28075509/complexation-and-electronic-communication-between-corannulene-based-buckybowls-and-a-curved-truxene-ttf-donor
#11
Maria Gallego, Joaquin Calbo, Rafael M Krick-Calderon, Paula Pla, Ya-Chu Hsieh, Emilio Manuel Pérez, Yao-Ting Wu, Enrique Orti, Dirk M Guldi, Nazario Martin
The association behavior of an electron-donating, bowl-shaped, truxene-based tetrathiafulvalene (truxTTF) with two corannulene-based fullerene fragments -C32H12 and C38H14- is investigated in several solvents. Formation of 1:1 complexes is followed by absorption titrations and complemented by density functional theory (DFT) calculations. The binding constants are in the range of log Ka 2.9-3.5. DFT calculations reveal that the conformation in which the 1,3-dithiole ring of truxTTF is placed inside the concave cavity of the corannulene derivative is the most stable arrangement...
January 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28074971/bio-orthogonal-click-and-release-donation-of-caged-carbonyl-sulfide-cos-and-hydrogen-sulfide-h2s
#12
Andrea K Steiger, Yang Yang, Maksim Royzen, Michael D Pluth
Hydrogen sulfide (H2S) is an important biomolecule with high therapeutic potential. Here we leverage the inverse-electron demand Diels-Alder (IEDDA) click reaction between a thiocarbamate-functionalized trans-cyclooctene and a tetrazine to deliver carbonyl sulfide (COS), which is quickly converted to H2S by the uniquitous enzyme carbonic anhydrase (CA), thus providing a new strategy for bio-orthogonal COS/H2S donation.
January 11, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28074969/direct-coordination-of-a-germanium-ii-dicationic-center-to-transition-metals
#13
Ravindra K Raut, Moumita Majumdar
The germanium(ii) center of dicationic compound 1 donates an electron pair to transition metal Ag(i) and Au(i) cations, leading to complexes 2 and 3 respectively. Complex 3 is stabilized by [Ge:](2+)→Au(i) σ-donation and π-back donation from filled d-orbitals of Au(i) to the two sets of p-orbitals available on Ge(ii) centers.
January 11, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28074490/rationally-designed-blue-triplet-emitting-gold-iiii-complexes-based-on-phenylpyridine-derived-framework
#14
Michael Bachmann, Jasmin Terreni, Olivier Blacque, Koushik Venkatesan
A series of blue emitting phosphorescent monocyclometalated Au(III) complexes were successfully synthesized. Tailoring substitutions at the phenylpyridine (ppy) ligand scaffold with the electron withdrawing fluorine groups at the phenyl ring to achieve stabilization of the HOMO and electron donating dimethylamino group on the pyridine ring to destabilize the LUMO resulted in a large energy gap and bestowed the gold(III) complexes with emission at high energies and high quantum efficiencies. Cyclic voltammetry (CV) studies are suggestive of a predominantly cyclometalated ligand localized redox event...
January 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28073821/learning-from-cross-border-reproduction
#15
Emily Jackson, Jenni Millbank, Isabel Karpin, Anita Stuhmcke
Drawing upon the preliminary findings of an Australian empirical project on cross-border reproduction (CBR), this article argues that regulators and policymakers could learn from the experiences of those who travel overseas in order to access fertility treatment and surrogacy. It makes four principal observations. First, the distinction between so-called 'altruistic' and 'commercial' gamete donation and surrogacy is increasingly unsustainable and is not experienced as meaningful by many participants in CBR...
January 10, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28073616/challenges-and-research-in-managing-blood-supply-in-china
#16
REVIEW
Yongming Zhu, Dongfu Xie, Xun Wang, Kaicheng Qian
Although considerable progress has been made in improving the blood service system in China over the last 2 decades, many challenges remain. A number of issues have received public attentions; however, others continue to be underacknowledged and controversial. This article describes 3 of these important and less emphasized issues: first, the ambiguity of the definition of voluntary nonremunerated blood donation and its relationship to an adequate blood supply; second, the current inadequacies of cost recovery from the blood service system; and third, the lack of a universally implemented program of hemovigilance...
December 5, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28073172/live-donation-to-the-extreme-saving-a-life-not-once-but-twice
#17
EDITORIAL
Nicolas Goldaracena, Nazia Selzner, Markus Selzner
No abstract text is available yet for this article.
January 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28072757/organ-procurement-organization-survey-of-practices-and-beliefs-regarding-prerecovery-percutaneous-liver-biopsy-in-donation-after-neurologic-determination-of-death
#18
Joseph Benton Oliver, Andrea Fleisch Marcus, Mark Paster, Joseph Nespral, Advaith Bongu, George Dikdan, Lloyd Brown, Nikole Neidlinger, Baburao Koneru
BACKGROUND: Prerecovery liver biopsy (PLB) allows histological evaluation of the organ prior to procurement. The opinions and what factors might influence PLB use within Organ Procurement Organizations (OPOs) are unknown. METHODS: A survey instrument was distributed by the Association of OPOs to the clinical directors of all 58 OPOs. Descriptive statistics were calculated. Results were also stratified based on OPO characteristics. RESULTS: 84...
January 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28072724/fatal-antiphospholipid-syndrome-following-endoscopic-transnasal-transsphenoidal-surgery-for-a-pituitary-tumor-a-case-report
#19
Chiao-Zhu Li, Chiao-Ching Li, Chih-Chuan Hsieh, Meng-Chi Lin, Dueng-Yuan Hueng, Feng-Chen Liu, Yuan-Hao Chen
INTRODUCTION: The fatal type of antiphospholipid syndrome is a rare but life-threating condition. It may be triggered by surgery or infection. Endoscopic transnasal-transsphenoidal surgery is a common procedure for pituitary tumor. We report a catastrophic case of a young woman died of fatal antiphospholipid syndrome following endoscopic transnasal-transsphenoidal surgery. METHODS AND RESULT: A 31-year-old woman of a history of stroke received endoscopic transnasal-transsphenoidal surgery for a pituitary tumor...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28072529/correlation-between-the-structure-and-catalytic-activity-of-cp-rh-substituted-bipyridine-complexes-for-nadh-regeneration
#20
Vinothkumar Ganesan, Dharmalingam Sivanesan, Sungho Yoon
A series of water-soluble half-sandwich [Cp*Rh(III)(N^N)Cl](+) (Cp* = pentamethylcyclopentadiene, N^N-substituted 2,2'-bipyridine) complexes containing electron-donating substituents around the 2,2'-bipyridyl ligand were synthesized and fully characterized for the regioselective reduction of nicotinamide coenzyme (NAD(+)). The influence of the positional effect of the substituents on the structural, electrochemical, and catalytic properties of the catalyst was systematically studied in detail. The catalytic efficiency of the substituted bipyridine Cp*Rh(III) complexes are inversely correlated with their redox potentials...
January 10, 2017: Inorganic Chemistry
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