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https://www.readbyqxmd.com/read/29241283/-there-is-no-season-for-gifts
#1
Klaus Lieb, Cora Koch
Gifts and payments from pharmaceutical manufacturers to medical doctors constitute a conflict of interest, which may lead to an undue influence on prescribing behavior. In Germany, 35 research-based pharmaceutical companies, organized in the "Verband der forschenden Arzneimittelhersteller (VfA)" paid € 562 million to medical doctors and hospitals in 2016. Of these, € 356 million were paid for clinical trials and non-interventional studies, € 105 million for sponsored presentations and CME and € 101 million went to hospitals and other organizations for sponsoring, consulting and events...
December 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29240709/prevalence-of-albuminuria-in-children-living-in-a-rural-agricultural-and-fishing-subsistence-community-in-lake-chapala-mexico
#2
Felipe Lozano-Kasten, Erick Sierra-Diaz, Alfredo de Jesus Celis-de la Rosa, María Margarita Soto Gutiérrez, Alejandro Aarón Peregrina Lucano
The occurrence of Chronic Kidney Disease (CKD) of unknown etiology in autochthonous child populations residing along the Lake Chapala lakeshore is endemic (Jalisco, México). The objective of this study was to determine the prevalence of albuminuria in the pediatric population and to measure the glomerular filtration rate in children with two positive albuminuria tests. Urinary albumin was measured in 394 children. Subjects with two or more positive albuminuria test donated blood samples for the determination of serum biomarkers...
December 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29239963/in-vitro-evaluation-of-a-novel-image-processing-device-to-estimate-surgical-blood-loss-in-suction-canisters
#3
Gerhardt Konig, Jonathan H Waters, Eric Hsieh, Bridget Philip, Vicki Ting, Gaurav Abbi, Mazyar Javidroozi, Griffeth W Tully, Gregg Adams
BACKGROUND: Clinicians are tasked with monitoring surgical blood loss. Unfortunately, there is no reliable method available to assure an accurate result. Most blood lost during surgery ends up on surgical sponges and within suction canisters. A novel Food and Drug Administration-cleared device (Triton system; Gauss Surgical, Inc, Los Altos, CA) to measure the amount of blood present on sponges using computer image analysis has been previously described. This study reports on performance of a complementary Food and Drug Administration-cleared device (Triton Canister System; Gauss Surgical, Inc, Los Altos, CA) that uses similar image analysis to measure the amount of blood in suction canisters...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29239953/the-impact-of-prehospital-tranexamic-acid-on-blood-coagulation-in-trauma-patients
#4
Philipp Stein, Jan-Dirk Studt, Roland Albrecht, Stefan Müller, Dieter von Ow, Simon Fischer, Burkhardt Seifert, Sergio Mariotti, Donat R Spahn, Oliver M Theusinger
BACKGROUND: There is limited data on prehospital administration of tranexamic acid (TXA) in civilian trauma. The aim of this study was to evaluate changes in coagulation after severe trauma from on-scene to the hospital after TXA application in comparison to a previous study without TXA. METHODS: The study protocol was registered at ClinicalTrials.gov (NCT02354885). A prospective, multicenter, observational study investigating coagulation status in 70 trauma patients receiving TXA (1 g intravenously) on-scene versus a control group of 38 patients previously published without TXA...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29239576/living-donor-kidney-transplantation
#5
Ilkka Helanterä, Eero Honkanen, Jutta Huhti, Helena Isoniemi, Hannu Jalanko, Marko Lempinen, Marja Miettinen, Arno Nordin, Risto Tertti, Satu Mäkelä
While the majority of kidney transplantations in Finland have been traditionally performed from deceased donors, the frequency of living donors should be increased. Kidney donation is a safe procedure for a carefully examined donor, and for the recipient living donation enables elective surgery and preemptive transplantation. Potential risks for the donor must be minimized, but according to current recommendations, mild hypertension or obesity are not absolute contraindications for donation. Guidelines for donor selection and examination have been updated to simplify the process for all parties...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29239091/extra-corporeal-normothermic-machine-perfusion-of-the-porcine-kidney-working-towards-future-utilization-in-australasia
#6
Ahmer M Hameed, Ray Miraziz, David B Lu, Neil Warwick, Ali El-Ayoubi, Heather Burns, Yi Vee Chew, Ross Matthews, Greg O'Grady, Lawrence Yuen, Natasha Rogers, Henry C Pleass, Wayne J Hawthorne
BACKGROUND: The ongoing supply-demand gap with respect to donor kidneys for transplantation necessitates the increased use of higher kidney donor profile index and/or donation after circulatory death (DCD) kidneys. Machine perfusion (MP) preservation has become increasingly popular as a means to preserve such organs. Human data regarding normothermic kidney MP (NMP) is in its infancy, and such a system has not been established in the Australasian clinical setting. METHODS: Modified cardio-pulmonary bypass technology was utilized to develop a viable NMP kidney perfusion system using a porcine DCD model...
December 14, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29237021/human-specific-subcellular-compartmentalization-of-p-element-induced-wimpy-testis-like-piwil-granules-during-germ-cell-development-and-spermatogenesis
#7
Maria Gomes Fernandes, Nannan He, Fang Wang, Liesbeth Van Iperen, Cristina Eguizabal, Roberto Matorras, Bernard A J Roelen, Susana M Chuva De Sousa Lopes
STUDY QUESTION: What is the dynamics of expression of P-element induced wimpy testis-like (PIWIL) proteins in the germline during human fetal development and spermatogenesis? SUMMARY ANSWER: PIWIL1, PIWIL2, PIWIL3 and PIWIL4 were expressed in a sex-specific fashion in human germ cells (GC) during development and adulthood. PIWILs showed a mutually exclusive pattern of subcellular localization. PIWILs were present in the intermitochondrial cement and a single large granule in meiotic GC and their expression was different from that observed in mice, highlighting species-differences...
December 11, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29237004/surrogacy-families-headed-by-gay-men-relationships-with-surrogates-and-egg-donors-fathers-decisions-over-disclosure-and-children-s-views-on-their-surrogacy-origins
#8
Nicola Carone, Roberto Baiocco, Demetria Manzi, Chiara Antoniucci, Victoria Caricato, Eugenio Pagliarulo, Vittorio Lingiardi
STUDY QUESTION: How do gay father families experience surrogacy in terms of their relationships with surrogates and egg donors, fathers' disclosure decisions and children's views on their surrogacy origins? SUMMARY ANSWER: More families had a relationship with the surrogate than the egg donor, and almost all had started to disclose to their children, the majority of whom expressed limited interest in their surrogacy conception. WHAT IS KNOWN ALREADY: Gay fathers tend to report greater contact with the surrogate than the egg donor and to disclose only the use of a surrogate (omitting discussion of the egg donor and the respective fathers' genetic relatedness)...
December 11, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29236472/analyzing-the-n-doping-mechanism-of-an-air-stable-small-molecule-precursor
#9
Martin Schwarze, Benjamin D Naab, Max L Tietze, Reinhard Scholz, Paul Pahner, Fabio Bussolotti, Satoshi Kera, Daniel Kasemann, Zhenan Bao, Karl Leo
Efficient n-doping of organic semiconductors requires electron donating molecules with small ionization energies, making such n-dopants usually sensitive to degradation under air exposure. A workaround consists in the usage of air stable precursor molecules containing the actual n-doping species. Here, we systematically analyze the doping mechanism of the small molecule precursor o-MeO-DMBI-Cl, which releases a highly reducing o-MeO-DMBI radical upon thermal evaporation. n-Doping of bis-HFl-NTCDI yields air stable and highly conductive films suitable for application as electron transport layer in organic solar cells...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235357/synthesis-characterization-and-biological-screening-of-pyrazole-conjugated-benzothiazole-analogs
#10
Mahesh Bhat, Shiddappa Lagamappa Belagali
AIM: Benzothiazole and pyrazoles are two important pharmacophores, the activity can be enhanced by conjugating them. Here, two novel series of the pyrazole-conjugated benzothiazole derivatives were synthesized. RESULTS: Synthesized compounds were characterized by Fourier-transform infrared, LC-MS, 1H NMR and 13C NMR spectroscopic techniques. Synthesized compounds exhibited moderate antimicrobial, antioxidant and excellent anti-TB activities. In in vitro anti-TB activity, 4d and 4e exhibited 1...
December 13, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29235132/mitochondrial-donation-patient-engagement-and-narratives-of-hope
#11
Cathy Herbrand, Rebecca Dimond
This article develops the sociology of hope and patient engagement by exploring how patients' perceptions and actions are shaped by narratives of hope surrounding the clinical introduction of novel reproductive techniques. In 2015, after extensive public debates, the UK became the first country to legalise a mitochondrial donation technique aimed at preventing the transmission of inherited disorders. The article draws on the accounts of twenty-two women of reproductive age who are at risk of having a child with mitochondrial disease and would be the potential target of the technique...
December 12, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29234748/early-loading-of-maxillary-titanium-implants-with-a-nanostructured-calcium-incorporated-surface-xpeed-5-year-results-from-a-multicentre-randomised-controlled-trial
#12
Giorgio Gastaldi, Maria Gabriella Grusovin, Pietro Felice, Carlo Barausse, Daniela Rita Ippolito, Marco Esposito
PURPOSE: To evaluate clinical safety and effectiveness of a novel calcium-incorporated titanium implant (Xpeed, MegaGen Implant Co. Limited, Gyeongbuk, South Korea). MATERIALS AND METHODS: In total, 60 patients were randomised to receive one to six titanium implants in the maxilla with either calcium-incorporated (Xpeed) or control resorbable blasted media (RBM) surfaces, according to a parallel group design at two centres. Implants were submerged and exposed at three different endpoints in equal groups of 20 patients at 12, 10 and 8 weeks, respectively...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29233812/proposals-for-opt-out-organ-donation-launched-for-england
#13
Gareth Iacobucci
No abstract text is available yet for this article.
December 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29231859/rational-engineering-of-a-flavoprotein-oxidase-for-improved-direct-oxidation-of-alcohols-to-carboxylic-acids
#14
Mathias Pickl, Christoph K Winkler, Silvia M Glueck, Marco W Fraaije, Kurt Faber
The oxidation of alcohols to the corresponding carbonyl or carboxyl compounds represents a convenient strategy for the selective introduction of electrophilic carbon centres into carbohydrate-based starting materials. The O₂-dependent oxidation of prim-alcohols by flavin-containing alcohol oxidases often yields mixtures of aldehyde and carboxylic acid, which is due to "over-oxidation" of the aldehyde hydrate intermediate. In order to directly convert alcohols into carboxylic acids, rational engineering of 5-(hydroxymethyl)furfural oxidase was performed...
December 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29230851/a-novel-case-control-subsampling-approach-for-rapid-model-exploration-of-large-clustered-binary-data
#15
Stephen T Wright, Louise M Ryan, Tung Pham
In many settings, an analysis goal is the identification of a factor, or set of factors associated with an event or outcome. Often, these associations are then used for inference and prediction. Unfortunately, in the big data era, the model building and exploration phases of analysis can be time-consuming, especially if constrained by computing power (ie, a typical corporate workstation). To speed up this model development, we propose a novel subsampling scheme to enable rapid model exploration of clustered binary data using flexible yet complex model set-ups (GLMMs with additive smoothing splines)...
December 11, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29230833/causes-of-iron-overload-in-blood-donors-a-clinical-study
#16
A H Laursen, O W Bjerrum, L Friis-Hansen, T O Hansen, J L Marott, K Magnussen
BACKGROUND AND OBJECTIVES: Despite the obligate iron loss from blood donation, some donors present with hyperferritinaemia that can result from a wide range of acute and chronic conditions including hereditary haemochromatosis (HH). The objective of our study was to investigate the causes of hyperferritinaemia in the blood donor population and explore the value of extensive HH mutational analyses. MATERIALS AND METHODS: Forty-nine consecutive donors (f = 6, m = 43) were included prospectively from the Capital Regional Blood Center...
December 12, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29230596/distribution-of-potential-eye-and-tissue-donors-within-an-australian-teaching-hospital
#17
Martin J Dutch, Anthony F Denahy
Eye and Tissue donation has the capacity to transform lives, yet the vast majority of potential in-hospital donors are not recognised. Studies which describe the relative importance of specific units or wards in determining the size of the donor pool are limited. The aim of this study was to map the distribution of potential Eye and Tissue donors within the study hospital. A 12-month retrospective analysis of all patient deaths at the study hospital was undertaken. The ability to donate corneal, heart valve, bone and skin tissue was investigated...
December 11, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29230502/-acceptance-of-post-mortem-organ-donation-in-germany-representative-cross-sectional-study
#18
E Tackmann, S Dettmer
BACKGROUND: The German post-mortem organ donation rate has dropped by one third since 2010. Furthermore, 958 patients died in 2015 in Germany while waiting for an organ. To decrease organ shortage, an amendment of the transplantation law was established in 2012. An information package including an organ donor card is sent to all German citizens via the postal service. A voluntary national transplantation register was introduced in 2016 to improve transparency in the organ donation process...
December 11, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29229159/socioeconomic-factors-as-predictors-of-organ-donation
#19
Malay B Shah, Valery Vilchez, Adam Goble, Michael F Daily, Jonathan C Berger, Roberto Gedaly, Derek A DuBay
BACKGROUND: Despite numerous initiatives to increase solid organs for transplant, the gap between donors and recipients widens. There is little in the literature identifying socioeconomic predictors for donation. We evaluate the correlation between socioeconomic factors and familial authorization for donation. METHODS: A retrospective analysis of adult potential donor referrals between 2007 and 2012 to our organ procurement organization (OPO) was performed. Potential donor information was obtained from the OPO database, death certificates, and the US Census Report...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29227984/microrna-146b-5p-identified-in-porcine-liver-donation-model-is-associated-with-early-allograft-dysfunction-in-human-liver-transplantation
#20
Cheukfai Li, Qiang Zhao, Wei Zhang, Maogen Chen, Weiqiang Ju, Linwei Wu, Ming Han, Yi Ma, Xiaofeng Zhu, Dongping Wang, Zhiyong Guo, Xiaoshun He
BACKGROUND Poor transplant outcome was observed in donation after brain death followed by circulatory death (DBCD), since the donor organs suffered both cytokine storm of brain death and warm ischemia injury. MicroRNAs (miRNAs) have emerged as promising disease biomarkers, so we sought to establish a miRNA signature of porcine DBCD and verify the findings in human liver transplantation. MATERIAL AND METHODS MiRNA expression was determined with miRNA sequencing in 3 types of the porcine model of organ donation, including donation after brain death (DBD) group, donation after circulatory death (DCD) group, and DBCD group...
December 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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