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Joline Tung, Lih Shin Tew, Carmine Coluccini, Yue-Der Lin, Yit Lung Khung
Here, we described the outcome of thermal grafting of 2-ethynylaniline, 3-ethynylaniline and 4-ethynylaniline respectively on hydrogenated Si(100) surface. Using high resolution X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM), it was found that the grafting of these compounds could be attributed to resonating structures that arises from the position of electron donating NH2 and the electron withdrawing acetylene group. For the ortho- and para-positioned acetylene group, surface reactions were observed to proceed predominantly via the acetylene to form a Si-C bond while the meta-positioned acetylene group was found to have undergone nucleophilic grafting through the NH2 onto the silicon surface to form Si-N bond...
June 22, 2018: Chemistry: a European Journal
Peng Zhu, Baobing Fan, Xiaoyan Du, Xiaofeng Tang, Ning Li, Feng Liu, Lei Ying, Zhenye Li, Wenkai Zhong, Christoph J Brabec, Fei Huang, Yong Cao
Two novel wide-band gap donor-acceptor-type conjugated copolymers, PTzBI-S and PTzBI-Ph, are designed and synthesized, based on alkylthio-thienyl- or alkylphenyl-substituted benzodithiophene (BDT) derivatives as the electron-donating unit and pyrrolo[3,4- f]benzotriazole-5,7(6 H)-dione as the electron-withdrawing unit. The as-generated copolymers show the comparable optical and electrochemical properties. The alkylthio-thienyl-substituted BDT unit facilities a benign decrease of the highest occupied molecular orbital (HOMO) levels...
June 22, 2018: ACS Applied Materials & Interfaces
A F C Hulsbergen, M L D Broekman
No abstract text is available yet for this article.
June 21, 2018: Acta Neurochirurgica
Victoria Gómez-Dos Santos, Mercedes Ruiz Hernández, Francisco Javier Burgos-Revilla
BACKGROUND: Hypothermic machine perfusion (HMP) of deceased donor kidneys is associated with a better outcome than static cold storage, predominantly in marginal donors. Nevertheless, there is little evidence supporting whether graft centre of origin and donor category impact HMP results. OBJECTIVE: To identify factors impacting HMP in transplantation from marginal donors. DESIGN, SETTING, AND PARTICIPANTS: Analysis of prospectively collected cohort data of expanded criteria donor (ECD) and donor after circulatory death (DCD) categories II and III was performed...
June 18, 2018: European Urology Focus
J Á Fernández-Vigo, J I Fernández-Vigo, P Serrano Garijo, J Donate-López
No abstract text is available yet for this article.
June 18, 2018: Archivos de la Sociedad Española de Oftalmología
Chunhua Cao, Eunkyoung Kim, Yi Liu, Mijeong Kang, Jinyang Li, Jun-Jie Yin, Huan Liu, Xue Qu, Changsheng Liu, William E Bentley, Gregory F Payne
Recent studies showed that melanin-mimetic catechol-chitosan films are redox-active and their ability to exchange electrons confers pro-oxidant activities for the sustained, in situ generation of reactive oxygen species for antimicrobial bandages. Here we electrofabricated catechol-chitosan films, demonstrate these films are redox-active, and show their ability to exchange electrons confers sustained radical scavenging activities that could be useful for protective coatings. Electrofabrication was performed in two steps: cathodic electrodeposition of a chitosan film followed by anodic grafting of catechol to chitosan...
June 21, 2018: Biomacromolecules
Bohdan Pomahac, Muayyad Alhefzi, Ericka M Bueno, Sue V McDiarmid, L Scott Levin
Living donation has become a medically and ethically accepted practice in solid organ transplantation. Published proceedings from the international kidney transplant community and from the Ethics Committee of The Transplantation Society (TTS) articulated the general principles as well as specific recommendations for living donation, which remain the backbone of the Centers for Medicare and Medicaid Services (CMS) and Organ Procurement and Transplantation Network (OPTN) requirements and policies.Meanwhile, there have been major advancements in another revolutionary field of transplant medicine: vascularized composite allotransplantation, or VCA...
June 14, 2018: Plastic and Reconstructive Surgery
Yibin Zhang, Shuai Xia, Mingxi Fang, Wafa Mazi, Yanbo Zeng, Taylor Johnston, Adam Pap, Rudy L Luck, Haiying Liu
New near-infrared rhodamine dyes with large Stokes shifts were developed and applied for sensitive detection of cellular pH changes and fluctuations by incorporating an additional amine group with fused rings into the rhodamine dyes to enhance the electron donating ability of amine groups and improve the spectroscopic properties of the dyes.
June 21, 2018: Chemical Communications: Chem Comm
Iestyn M Shapey, Angela M Summers, Iain J Simkin, Titus Augustine, David van Dellen
Brexit may lead to major political, societal, and financial changes-this has significant implications for a tax revenue funded healthcare system such as the United Kingdom's (UK) National Health Service. The complex relationship between European Union (EU) legislation and clinical practice of organ donation and transplantation is poorly understood. However, it is unclear what impact Brexit may have on organ donation and transplantation in the UK and EU. This work aims to describe the current legislative interactions affecting organ donation and transplantation regulation and governance within the UK and EU...
June 21, 2018: Clinical Transplantation
Rob Leurs, Xavier Gómez-Santacana, Sabrina M de Munnik, Prashanna Vijayachandran, Daniel Da Costa Pereira, Jan Paul M Bebelman, Iwan J P de Esch, Henry F Vischer, Maikel Wijtmans
In order to obtain optical control of GPCR function, we set out to develop small-molecule ligands with photoswitchable efficacy in which both configurations bind the target protein but exert distinct pharmacological effects, i.e., stimulate or antagonise GPCR activation. Our design was based on a previously identified efficacy hotspot for the peptidergic chemokine receptor CXCR3 and resulted in the synthesis and characterization of five new azobenzene-containing CXCR3 ligands. G protein activation assay and real-time electrophysiology experiments demonstrated a photoswitching from antagonism to partial agonism and even to full agonism (VUF16216)...
June 21, 2018: Angewandte Chemie
Benjy Yi-Min Soh, Rajneesh Kumar, Victoria Sze-Min Ekstrom, Clement Yi-Hao Lin, Sobhana D/O Thangaraju, Hwee Huang Tan, Kwai Peng Chan, Lina Hui Lin Choong, Diana Teo, Wan Cheng Chow
INTRODUCTION: To study the prevalence of hepatitis C virus (HCV)-infection in blood donor (BD), haemodialysis (HD) and intravenous drug user (IVDU) populations in Singapore and assess the IL28B polymorphism if HCV positive. METHODS: The BD population were healthy volunteers, the HD population were patients who were on haemodialysis for at least 6 months of follow-up between Jan 2009 and Dec2014. IVDU population was from inmates at half-way houses who consented. RESULTS: Between 2011 and 2014, of 161,658 individuals screened for blood donation, 42 (0...
June 21, 2018: Singapore Medical Journal
Ting Fan, Ao Wang, Jia-Qi Li, Jian-Liang Ye, Xiao Zheng, Pei-Qiang Huang
The imino-Nazarov cyclization of the polysubstituted pentan-1,4-diene-3-imine is realized. To this aim, a one-pot procedure involving reductive alkenyliminylation of α,β-unsaturated secondary amides with potassium organotrifluoroborates followed by acid-catalyzed imino-Nazarov cyclization of the polysubstituted pentan-1,4-diene-3-imine intermediates is studied systematically. This mild, operationally simple, flexible, and high-yielding protocol efficiently affords polysubstituted pentan-1,4-diene-3-imines, cyclopentenimines, and α-amino cyclopentenones, which are useful scaffolds in organic synthesis...
June 20, 2018: Angewandte Chemie
Shui Hung Wong, Amy Yin Man Chow
The posthumous organ donation reasoned action scale (PODRAS) may be the first multidimensional scale measuring individuals' perceptions, which is developed based on the Theory of Reasoned Action and guided by empirical data. This study moves further to validate the scale and examine its psychometric properties. Two hundred and twenty-one university students participated in the study. Results suggested that the scale has a structure with six dimensions: Mutilation and Imperfectness, Legacy for Family, Altruism, Detachment, Eradication of Hope, and Burden on Family...
January 1, 2018: Omega
Frank S Benneckendorf, Sabina Hillebrandt, Florian Ullrich, Valentina Rohnacher, Sebastian Hietzschold, Daniel Jänsch, Jan Freudenberg, Sebastian Beck, Eric Mankel, Wolfram Jaegermann, Annemarie Pucci, Uwe H F Bunz, Klaus Müllen
Studying the structure-property relations of tailored dipolar phenyl and biphenylphosphonic acids we report self-assembled monolayers with a significant decrease of the work function (WF) of indium-tin oxide (ITO) electrodes. While the strengths of the dipoles are varied through the different molecular lengths and the introduction of electron-withdrawing fluorine atoms, the surface energy is kept constant through the electron-donating N,N dimethylamine head groups. The self-assembled monolayer formation and its modification of the electrodes are investigated via infrared reflection absorption spectroscopy, contact angle measurements, and photoelectron spectroscopy...
June 20, 2018: Journal of Physical Chemistry Letters
Oscar K Serrano, Kunal Yadav, Ananta Bangdiwala, David M Vock, Ty B Dunn, Erik B Finger, Timothy L Pruett, Arthur J Matas, Raja Kandaswamy
With increasing organ demand, living kidney donation from older donors (>60-years-old) has become more common. Between 1975 and 2014, 3752 donor nephrectomies (DN) were performed at University of Minnesota; 167 (4.5%) were >60-years-old Short- and long-term outcomes were compared between contemporaneous >60-years-old and <60-years-old donors. On univariate analysis, >60-years-old were more likely to have had prior abdominal surgery and hypertension; and less likely to smoke. Baseline estimated glomerular filtration rate (eGFR) was lower in >60-years-old (80 ± 16 vs 101 ± 26 mL/min/1...
June 20, 2018: Clinical Transplantation
Y Sawamura, H Ohto, K Ikeda, T Kanno, Y Suzuki, K Gonda, T Tasaki, K E Nollet, H Takahashi, S Aota
BACKGROUND: Although prestorage leucoreduction (LR) of blood components for transfusion has gained favour around the world, evidence of its beneficial clinical effects is ambiguous. STUDY DESIGN AND METHODS: To reveal whether leucocytes and/or platelets in transfused blood are related to transfusion-related adverse effects, a prospective randomized crossover study was performed on patients who donated autologous blood prior to elective surgery. Among 1487 primary enrolees, a total of 192 patients undergoing two-stage, bilateral total hip arthroplasty were randomized to receive autologous blood that was either prestorage leucoreduced, or not, for the first procedure...
June 20, 2018: Vox Sanguinis
Jiah Lim, Yoojin Song, Jung-Hee Jang, Chul-Ho Jeong, Sooyeun Lee, Byoungduck Park, Young Ho Seo
Aspirin is one of the oldest drugs for the treatment of inflammation, fever, and pain. It is reported to covalently modify COX-2 enzyme by acetylating a serine amino acid residue. By virtue of aspirin's acetylating potential, we for the first time developed novel acetyl-donating HDAC inhibitors. In this study, we report the design, synthesis, in silico docking study, and biological evaluation of acetyl-donating HDAC inhibitors. The exposure of MDA-MB-231 cells with compound 4c significantly promotes the acetylation of α-tubulin and histone H3, which are substrates of HDAC6 and HDAC1, respectively...
June 20, 2018: Archives of Pharmacal Research
Jun Luo
Pro-social behaviors are voluntary behaviors that benefit other people or society as a whole, such as charitable donations, cooperation, trust, altruistic punishment, and fairness. These behaviors have been widely described through non self-interest decision-making in behavioral experimental studies and are thought to be increased by social preference motives. Importantly, recent studies using a combination of neuroimaging and brain stimulation, designed to reveal the neural mechanisms of pro-social behaviors, have found that a wide range of brain areas, specifically the prefrontal cortex, anterior insula, anterior cingulate cortex, and amygdala, are correlated or causally related with pro-social behaviors...
2018: Frontiers in Psychology
Andrew M Williams, Kelly W Muir
There is a severe shortage of donor corneas available worldwide for transplantation, with the number of patients in need of transplant greatly exceeding the number of cornea tissues available. Understanding awareness and attitudes about corneal donation worldwide is a critical step toward addressing this shortage. In this review, awareness of corneal donation and reported willingness to donate are summarized from 55 published studies across 13 countries. In general, many more respondents indicated positive attitudes toward eye donation and willingness to donate their eyes than the number of respondents who have pledged their eyes for donation, suggesting an unrealized potential of additional donors...
2018: Clinical Ophthalmology
Muhammad Awais Naeem, Andac Armutlulu, Qasim Imtiaz, Felix Donat, Robin Schäublin, Agnieszka Kierzkowska, Christoph R Müller
Calcium looping, a CO2 capture technique, may offer a mid-term if not near-term solution to mitigate climate change, triggered by the yet increasing anthropogenic CO2 emissions. A key requirement for the economic operation of calcium looping is the availability of highly effective CaO-based CO2 sorbents. Here we report a facile synthesis route that yields hollow, MgO-stabilized, CaO microspheres featuring highly porous multishelled morphologies. As a thermal stabilizer, MgO minimized the sintering-induced decay of the sorbents' CO2 capacity and ensured a stable CO2 uptake over multiple operation cycles...
June 19, 2018: Nature Communications
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