keyword
https://read.qxmd.com/read/38533718/patient-genetic-heterogeneities-acting-as-indicators-of-post-operative-pain-and-opioid-requirement-in-orthopedic-surgery-a-systematic-review
#1
JOURNAL ARTICLE
Ahmad Hasan, Adam Pearl, Mohammad Daher, Khaled J Saleh
INTRODUCTION: Orthopedic surgical procedures are expected to increase annually, making it imperative to understand the correlations between patient genetic makeup and post-operative pain levels. METHODS: We performed a systematic literature review using PubMed and Cochrane databases in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A total of 299 articles were initially selected, 20 articles remained after title and abstract review, and nine articles were selected for inclusion upon full text review...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38399570/brexpiprazole-attenuates-aggression-suicidality-and-substance-use-in-borderline-personality-disorder-a-case-series
#2
Benedict Francis, Vijay A/L Ganasan, Abdul Rasyid Bin Sulaiman
Background : Borderline personality disorder (BPD) is a heterogeneous and highly comorbid disorder. Suicidality, aggression and substance abuse are common presentations of BPD. Our case series is the first to highlight the role of brexpiprazole in improving these symptoms in patients with BPD. Case presentation : We describe three cases demonstrating the role of brexpiprazole in improving BPD's prominent features and comorbidities. All cases improved when brexpiprazole was added to their treatment regime. Case 1: A 26-year-old woman who was diagnosed with BPD and cyclothymia, presented to the psychiatric emergency unit with impulsive suicidal behaviour...
February 7, 2024: Medicina
https://read.qxmd.com/read/38396013/effect-of-antipsychotic-drugs-on-group-ii-metabotropic-glutamate-receptor-expression-and-epigenetic-control-in-postmortem-brains-of-schizophrenia-subjects
#3
JOURNAL ARTICLE
Jon DelaCuesta-Barrutia, Oihane Martínez-Peula, Guadalupe Rivero, Jon A Santas-Martín, Eva Munarriz-Cuezva, Iria Brocos-Mosquera, Patricia Miranda-Azpiazu, Rebeca Diez-Alarcia, Benito Morentin, William G Honer, Luis F Callado, Amaia M Erdozain, Alfredo Ramos-Miguel
Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu2 R and mGlu3 R) in brains of schizophrenia patients may explain the limited efficacy of mGlu2/3 R ligands in clinical trials. Studies evaluating mGlu2/3 R levels in well-designed, large postmortem brain cohorts are needed to address this issue. Postmortem samples from the dorsolateral prefrontal cortex of 96 schizophrenia subjects and matched controls were collected. Toxicological analyses identified cases who were (AP+) or were not (AP-) receiving antipsychotic treatment near the time of death...
February 23, 2024: Translational Psychiatry
https://read.qxmd.com/read/38389788/methylone-is-a-rapid-acting-neuroplastogen-with-less-off-target-activity-than-mdma
#4
JOURNAL ARTICLE
Jennifer Warner-Schmidt, Martin Stogniew, Blake Mandell, R Scott Rowland, Eric F Schmidt, Benjamin Kelmendi
BACKGROUND: Post-traumatic stress disorder (PTSD) is a highly prevalent psychiatric disorder that can become chronic and debilitating when left untreated. Available pharmacotherapies are limited, take weeks to show modest benefit and remain ineffective for up to 40% of patients. Methylone is currently in clinical development for the treatment of PTSD. Preclinical studies show rapid, robust and long-lasting antidepressant-like and anxiolytic effects. The mechanism of action underlying these effects is not yet fully understood...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38376511/withdrawal-syndrome-after-antipsychotics-discontinuation-an-analysis-of-the-who-database-of-spontaneous-reports-vigibase-between-2000-and-2022
#5
JOURNAL ARTICLE
Wilhelm Storck, Tanguy Taillefer de Laportalière, Antoine Yrondi, Hervé Javelot, Fabrice Berna, François Montastruc
RATIONALE: Withdrawal syndrome (WDS) has been described after discontinuation of antipsychotics. WDS could be the consequence of an over-activation of the dopaminergic pathway. Antipsychotics with a higher affinity for dopamine D2 receptors could be associated with a higher risk of WDS. This study aims to address this statement and evaluate the risk difference for withdrawal syndrome between antipsychotics based on pharmacovigilance data. METHODS: We collected individual reports registered in Vigibase® between 01/01/2000 and 31/12/2022 of patients treated with antipsychotics and who had presented WDS...
February 20, 2024: Psychopharmacology
https://read.qxmd.com/read/38255760/5-ht-2a-receptor-knockout-mice-show-sex-dependent-differences-following-acute-noribogaine-administration
#6
JOURNAL ARTICLE
Sofía Villalba, Bruno González, Stephanie Junge, Alejandra Bernardi, Joaquín González, Catherine Fagúndez, Pablo Torterolo, Ignacio Carrera, Francisco J Urbano, Verónica Bisagno
Noribogaine (noribo) is the primary metabolite from ibogaine, an atypical psychedelic alkaloid isolated from the root bark of the African shrub Tabernanthe iboga . The main objective of this study was to test the hypothesis that molecular, electrophysiological, and behavioral responses of noribo are mediated by the 5-HT2A receptor (5-HT2A R) in mice. In that regard, we used male and female, 5-HT2A R knockout (KO) and wild type (WT) mice injected with a single noribo dose (10 or 40 mg/kg; i.p.). After 30 min...
January 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38245505/discovery-of-a-peripheral-5ht-2a-antagonist-as-a-clinical-candidate-for-metabolic-dysfunction-associated-steatohepatitis
#7
JOURNAL ARTICLE
Haushabhau S Pagire, Suvarna H Pagire, Byung-Kwan Jeong, Won-Il Choi, Chang Joo Oh, Chae Won Lim, Minhee Kim, Jihyeon Yoon, Seong Soon Kim, Myung Ae Bae, Jae-Han Jeon, Sungmin Song, Hee Jong Lee, Eun Young Lee, Peter C Goughnour, Dooseop Kim, In-Kyu Lee, Rohit Loomba, Hail Kim, Jin Hee Ahn
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is currently the leading cause of chronic liver disease worldwide. Metabolic Dysfunction-Associated Steatohepatitis (MASH), an advanced form of MASLD, can progress to liver fibrosis, cirrhosis, and hepatocellular carcinoma. Based on recent findings by our team that liver 5HT2A knockout male mice suppressed steatosis and reduced fibrosis-related gene expression, we developed a peripheral 5HT2A antagonist, compound 11c for MASH. It shows good in vitro activity, stability, and in vivo pharmacokinetics (PK) in rats and dogs...
January 20, 2024: Nature Communications
https://read.qxmd.com/read/37941526/peripheral-edema-associated-with-antidepressant-use-systematic-review-of-case-reports
#8
REVIEW
Jithin T Joseph, Rashmi Vishwanath, Samir Kumar Praharaj
BACKGROUND: Oedema associated with psychotropics can impose a considerable burden, leading to increased morbidity and cost. Peripheral oedema is sometimes related to the use of antidepressants, which are among the most prescribed psychotropic medications. We reviewed the reported cases of antidepressant-associated oedema to understand the risk factors, aetiology and outcome. METHODS: We searched the Medline, Web of Science and Embase databases to identify reported cases of peripheral oedema associated with antidepressant use...
November 2023: Human Psychopharmacology
https://read.qxmd.com/read/37884227/multi-effective-components-and-their-target-mechanism-of-ziziphi-spinosae-semen-in-the-treatment-of-insomnia
#9
JOURNAL ARTICLE
Xinwei Zhao, Tao Hou, Han Zhou, Ziling Liu, Yanfang Liu, Chaoran Wang, Zhimou Guo, Dongping Yu, Qing Xu, Jixia Wang, Xinmiao Liang
Insomnia is a common and refractory disease. Since more than 2000 years ago, people have been using Ziziphi Spinosae Semen (ZSS). However, there are lack of molecular mechanisms of sleep promotion effects of ZSS. The purpose of this study is to clarify the active ingredients in ZSS that are used to treat insomnia. Using a method called cellular label-free integrative pharmacology (CLIP), we established five insomnia-related target models, including serotonin (5HT2A and 5HT1A ), melatonin (MT1 ), dopamine (D2 ) and epinephrine (β2 ) receptors...
October 24, 2023: Fitoterapia
https://read.qxmd.com/read/37684231/serotonin-signaling-regulates-actomyosin-contractility-during-morphogenesis-in-evolutionarily-divergent-lineages
#10
JOURNAL ARTICLE
Sanjay Karki, Mehdi Saadaoui, Valentin Dunsing, Stephen Kerridge, Elise Da Silva, Jean-Marc Philippe, Cédric Maurange, Thomas Lecuit
Serotonin is a neurotransmitter that signals through 5-HT receptors to control key functions in the nervous system. Serotonin receptors are also ubiquitously expressed in various organs and have been detected in embryos of different organisms. Potential morphogenetic functions of serotonin signaling have been proposed based on pharmacological studies but a mechanistic understanding is still lacking. Here, we uncover a role of serotonin signaling in axis extension of Drosophila embryos by regulating Myosin II (MyoII) activation, cell contractility and cell intercalation...
September 8, 2023: Nature Communications
https://read.qxmd.com/read/37654035/neuroprotective-effects-of-goji-berry-lycium-barbarum-l-polysaccharides-on-depression-like-behavior-in-ovariectomized-rats-behavioral-and-biochemical-evidence
#11
JOURNAL ARTICLE
Hayriye Soytürk, Bihter Gökçe Bozat, Fatma Pehlivan Karakas, Hamit Coskun, Tulin Firat
AIM: To assess the protective effects of goji berry (Lycium barbarum L.) polysaccharides (LBP) on depression-like behavior in ovariectomized rats and to elucidate the mechanisms underlying these effects. METHODS: One hundred female Wistar albino rats (three months old) were randomly assigned either to ovariectomy (n=50) or sham surgery (n=50). After a 14-day recovery period, the groups were divided into five treatment subgroups (10 per group): high-dose LBP (200 mg/kg), low-dose LBP (20 mg/kg), imipramine (IMP, 2...
August 31, 2023: Croatian Medical Journal
https://read.qxmd.com/read/37611917/putative-neural-mechanisms-underlying-release-mode-specific-abnormalities-in-dopamine-neural-activity-in-a-schizophrenia-like-model-the-distinct-roles-of-glutamate-and-serotonin-in-the-impaired-regulation-of-dopamine-neurons
#12
JOURNAL ARTICLE
Hidekazu Sotoyama
Abnormalities in dopamine function might be related to psychiatric disorders such as schizophrenia. Even at the same concentration, dopamine exerts opposite effects on information processing in the prefrontal cortex depending on independent dopamine release modes known as tonic and phasic releases. This duality of dopamine prevents a blanket interpretation of the implications of dopamine abnormalities for diseases on the basis of absolute dopamine levels. Moreover, the mechanisms underlying the mode-specific dopamine abnormalities are not clearly understood...
August 23, 2023: European Journal of Neuroscience
https://read.qxmd.com/read/37523044/reduced-expression-of-the-htr2a-grin1-and-bdnf-genes-and-cognitive-inflexibility-in-a-model-of-high-compulsive-rats
#13
JOURNAL ARTICLE
Ángeles Prados-Pardo, Elena Martín-González, Santiago Mora, Carlos Martín, Manuela Olmedo-Córdoba, Cristian Pérez-Fernandez, Fernando Sánchez-Santed, Margarita Moreno-Montoya
Compulsivity is a core symptom in different psychopathological disorders, characterized by excessive behaviors and behavioral inflexibility. The selection of high drinker (HD) versus low drinker (LD) rats by schedule-induced polydipsia (SIP) is a valid model for studying the compulsive phenotype. The compulsive HD rats showed cognitive inflexibility and reduced serotonin 2A (5-HT2A) receptor binding levels in the frontal cortex (FC). According to that, we hypothesize that compulsive HD rats might have an alteration in the cognitive control domain regarding inflexibility, assessed by spatial memory on the Morris Water Maze (MWM), working and reference memory by the Radial Arm Maze, and behavioral deficits in stimulus processing by the Novel Object Recognition test...
July 31, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37477254/olanzapine-manipulates-neuroactive-signals-and-may-onset-metabolic-disturbances
#14
JOURNAL ARTICLE
Pukar Khanal, Farshid Zargari, Yadu Nandan Dey, Zahra Nikfarjam
Olanzapine is one of the most prescribed atypical antipsychotics to treat psychiatric illness and is associated with weight gain and metabolic disturbance. The present study investigated the olanzapine-regulated metabolic pathways using functional enrichent analysis including binding affinity with G-protein-coupled receptors (GPCRs). Proteins modulated by olanzapine were retrieved from SwissTargetPrediction, DIGEP-Pred, and BindingDB and then enriched in Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) to assess molecular function, biological process, and cellular components including Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways...
July 21, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/37475559/the-natural-protoalkaloid-methyl-2-amino-3-methoxybenzoate-mam-alleviates-positive-as-well-as-cognitive-symptoms-in-rat-and-mouse-schizophrenia-models
#15
JOURNAL ARTICLE
Yami Bright, Dorien A Maas, Michel M M Verheij, Maria Serena Paladini, Helene I V Amatdjais-Groenen, Raffaella Molteni, Marco A Riva, Gerard J M Martens, Judith R Homberg
The development of new antipsychotics with pro-cognitive properties and less side effects represents a priority in schizophrenia drug research. In this study, we present for the first time a pre-clinical exploration of the effects of the promising natural atypical antipsychotic Methyl-2-Amino-3- Methoxybenzoate (MAM), a brain-penetrable protoalkaloid from the seed of the plant Nigella dama- scena. Using animal models related to hyperdopaminergic activity, namely the pharmacogenetic apo- morphine (D2/D1 receptor agonist)-susceptible (APO-SUS) rat model and pharmacologically induced mouse and rat models of schizophrenia, we found that MAM reduced gnawing stereotypy and climb- ing behaviours induced by dopaminergic agents...
July 20, 2023: Current Neuropharmacology
https://read.qxmd.com/read/37466404/abnormal-glutamatergic-and-serotonergic-connectivity-in-visual-snow-syndrome-and-migraine-with-aura
#16
JOURNAL ARTICLE
Francesca Puledda, Ottavia Dipasquale, Benjamin J M Gooddy, Nazia Karsan, Ray Bose, Mitul A Mehta, Steven C R Williams, Peter J Goadsby
OBJECTIVE: Neuropharmacological changes in visual snow syndrome (VSS) are poorly understood. We aimed to use receptor target maps combined with resting functional magnetic resonance imaging (fMRI) data to identify which neurotransmitters might modulate brain circuits involved in VSS. METHODS: We used Receptor-Enriched Analysis of Functional Connectivity by Targets (REACT) to estimate and compare the molecular-enriched functional networks related to 5 neurotransmitter systems of patients with VSS (n = 24), healthy controls (HCs; n = 24), and migraine patients ([MIG], n = 25, 15 of whom had migraine with aura [MwA])...
November 2023: Annals of Neurology
https://read.qxmd.com/read/37238985/the-effects-of-antipsychotics-in-experimental-models-of-krabbe-disease
#17
JOURNAL ARTICLE
Kapil Sharma, Kumlesh K Dev
The role of altered myelin in the onset and development of schizophrenia and changes in myelin due to antipsychotics remains unclear. Antipsychotics are D2 receptor antagonists, yet D2 receptor agonists increase oligodendrocyte progenitor numbers and limit oligodendrocyte injury. Conflicting studies suggest these drugs promote the differentiation of neural progenitors to oligodendrocyte lineage, while others report antipsychotics inhibit the proliferation and differentiation of oligodendrocyte precursors. Here, we utilised in-vitro (human astrocytes), ex-vivo (organotypic slice cultures) and in-vivo (twitcher mouse model) experimental study designs of psychosine-induced demyelination, a toxin that accumulates in Krabbe disease (KD), to investigate direct effects of antipsychotics on glial cell dysfunction and demyelination...
April 28, 2023: Biomedicines
https://read.qxmd.com/read/37238670/platelet-serotonin-5-ht-concentration-platelet-monoamine-oxidase-b-mao-b-activity-and-htr2a-htr2c-and-maob-gene-polymorphisms-in-asthma
#18
JOURNAL ARTICLE
Marcela Konjevod, Katherina B Sreter, Sanja Popovic-Grle, Marina Lampalo, Lucija Tudor, Irena Jukic, Gordana Nedic Erjavec, Jasna Bingulac-Popovic, Hana Safic Stanic, Matea Nikolac Perkovic, Jasenka Markeljevic, Miroslav Samarzija, Nela Pivac, Dubravka Svob Strac
The complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. Our study investigated platelet serotonin (5-HT) levels and platelet monoamine oxidase B (MAO-B) activity, as well as associations with HTR2A (rs6314; rs6313) , HTR2C (rs3813929; rs518147), and MAOB (rs1799836; rs6651806) gene polymorphisms in 120 healthy individuals and 120 asthma patients of different severity and phenotypes. Platelet 5-HT concentration was significantly lower, while platelet MAO-B activity was considerably higher in asthma patients; however, they did not differ between patients with different asthma severity or phenotypes...
May 8, 2023: Biomolecules
https://read.qxmd.com/read/37141133/-treatment-of-mental-disorders-caused-or-triggered-by-somatic-and-neurological-diseases-with-the-use-of-the-multimodal-antidepressant-trazodone
#19
JOURNAL ARTICLE
D V Romanov, M D Samsonova, P G Iuzbashian
The purpose of this narrative review is to relate current data on the molecular mechanisms of action of trazodone with its clinical effects and applicability in mental disorders caused or triggered by somatic and neurological disease, according to available publications. In the article, the prospects for the use of the multimodal antidepressant trazodone are discussed in accordance with therapeutic targets. The latter are discussed in accordance with the typology of the mentioned above psychosomatic disorders...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/37119932/distribution-of-5ht-receptors-during-the-regeneration-process-after-spinal-cord-transection-in-goldfish
#20
JOURNAL ARTICLE
Akihito Takeda, Mao Fujita, Kengo Funakoshi
Spinal cord injury in teleosts leads to a fibrous scar, but axons sometimes spontaneously regenerate beyond the scar. In goldfish, regenerating axons enter the scar through tubular structures and enlargement of the tubular diameter is proportional to the increase in the number of regenerating axons. During the regeneration process, mast cells containing 5-hydroxytryptamine (5HT) are recruited to the injury site, and 5HT neurons are newly generated. Here, we investigated the distribution of 5HT receptors during this process to determine their role in remodeling the fibrous scar and tubular structures...
April 27, 2023: Journal of Chemical Neuroanatomy
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