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https://www.readbyqxmd.com/read/28644238/prevention-and-management-of-descemet-membrane-endothelial-keratoplasty-complications
#1
Ruth Quilendrino, Marina Rodriguez-Calvo de Mora, Lamis Baydoun, Lisanne Ham, Korine van Dijk, Isabel Dapena, Silke Oellerich, Gerrit R J Melles
PURPOSE: To describe Descemet membrane endothelial keratoplasty (DMEK) complications and strategies for their prevention and management. METHODS: Five hundred consecutive eyes with DMEK of 393 patients were reviewed in this retrospective study for intraoperative and postoperative complications up to 2 years and for corresponding management. RESULTS: Intraoperative challenges (difficult graft unfolding/positioning, high vitreous pressure, iris root hemorrhage, and Descemet membrane remnants) were encountered in 81 eyes (16...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28626416/multiquadrant-subtenon-triamcinolone-injection-for-acute-corneal-graft-rejection-a-case-report
#2
Sunali Goyal, Sami H Uwaydat
BACKGROUND: We report a case of reversal of an acute corneal graft rejection following multiquadrant subtenon triamcinolone injection. CASE PRESENTATION: A 19-year-old woman who had acute corneal graft rejection failed to show resolution of the graft rejection after standard treatment with systemic, intravenous, and topical steroids. The graft rejection, however, responded to injection of triamcinolone in multiple subtenon quadrants. CONCLUSIONS: For corneal graft rejection, multiquadrant subtenon triamcinolone injections may be a safe adjunct to systemic treatment...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28614429/clinical-and-epidemiological-aspects-of-cornea-transplant-patients-of-a-reference-hospital
#3
Giovanna Karinny Pereira Cruz, Isabelle Campos de Azevedo, Diana Paula de Souza Rego Pinto Carvalho, Allyne Fortes Vitor, Viviane Euzébia Pereira Santos, Marcos Antonio Ferreira
Objective: clinically characterizing cornea transplant patients and their distribution according to indicated and post-operative conditions of cornea transplantation, as well as estimating the average waiting time. Method: a cross-sectional, descriptive and analytical study performed for all cornea transplants performed at a reference service (n=258). Data were analyzed using Statistical Package for the Social Sciences, version 20.0. Results: the main indicator for cornea transplant was keratoconus...
June 8, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28610538/study-of-death-to-preservation-time-and-its-impact-on-utilisation-of-donor-corneas
#4
Dhaval Patel, Radhika Tandon, Anita Ganger, Aarti Vij, Sanjeev Lalwani, Adarsh Kumar
To evaluate the impact of death-to-preservation time (DPT) on effective utilisation of donor corneas. In a prospective observational study conducted at our tertiary eye centre, donated corneas received over a 15-month period from November 2011 to January 2013 were evaluated. Donor age, donor refrigeration (done or not), DPT, endothelial cell density (ECD), corneal grading, clinical utilisation and surgical outcome after graft transplantation were noted. To analyse the impact of different DPT on donor cornea transplantation, primary outcome measures (corneal grading and endothelial cell density) and secondary outcome measures (primary graft failure and graft infection) were analysed...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28608272/ctg18-1-repeat-expansion-may-reduce-tcf4-gene-expression-in-corneal-endothelial-cells-of-german-patients-with-fuchs-dystrophy
#5
Sabine Foja, Mirjam Luther, Katrin Hoffmann, Andreas Rupprecht, Claudia Gruenauer-Kloevekorn
PURPOSE: It was the aim of this investigation to elucidate the functional effects of CTG18.1 trinucleotide repeat expansion and the polymorphism rs613872 in the transcription factor 4 (TCF4) in corneas of patients affected by Fuchs' endothelial corneal dystrophy (FECD). METHODS: Sixty-one unrelated German patients with FECD and 113 unaffected controls were investigated and genotyped for the CTG18.1 locus by triplet primed PCR (TP-PCR) and the rs613872 polymorphism via Sanger sequencing and by employing genomic DNA from peripheral blood leucocytes...
June 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28604983/visual-outcomes-of-the-second-eye-in-keratoconic-patients-who-have-a-corneal-graft-in-the-first-eye-analysis-at-12-years
#6
Anne-Sophie Gauthier, Marie Friot, Marc Puyraveau, Thibaud Garcin, Maher Saleh, Phillipe Gain, Bernard Delbosc
PURPOSE: To analyze demographic, clinical, and keratometric outcomes of the second eye in keratoconic patients when the first eye has already been grafted, initially and finally at 12 years. METHODS: Retrospective analysis of initial and 12 years visual and keratometric outcomes of the second eye in keratoconic patients when the first one has already been grafted. RESULTS: A total of 107 patients were included: 66 patients were analyzed at the beginning of the follow-up and at 12 years...
June 10, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28600303/stability-of-visual-outcome-between-2-and-5-years-following-corneal-transplantation-in-the-uk
#7
Sing-Pey Chow, Cathy L Hopkinson, Derek M Tole, Mark N Jones, Stuart D Cook, W John Armitage
BACKGROUND AND AIMS: Many studies of corneal transplantation focus on graft failure or rejection as endpoints, or report visual outcomes at one postoperative time point. We aimed to study the stability of visual outcomes between 2 and 5 years following corneal transplantation. METHODS: All patients with keratoconus (868) or Fuchs endothelial dystrophy (FED) (569) receiving their first corneal transplant for visual purposes in the UK between January 2003 and December 2009 were included...
June 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28598869/graft-versus-host-disease-what-should-the-oculoplastic-surgeon-know
#8
Cynthia I Tung
PURPOSE OF REVIEW: To provide a concise review of the oculoplastic manifestations of ocular graft versus host disease (GVHD), and to discuss their management. RECENT FINDINGS: Ocular GVHD occurs as a common immune-mediated complication of hematopoietic stem cell transplantation that presents as a Stevens-Johnson-like syndrome in the acute phase or a Sjögren-like syndrome in the chronic phase. Cicatricial conjunctivitis may be underreported in ocular GVHD. The spectrum of oculoplastic manifestations includes GVHD of the skin, cicatricial entropion, nasolacrimal duct obstruction, and lacrimal gland dysfunction...
June 8, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28594697/comparison-of-femtosecond-laser-enabled-descemetorhexis-and-manual-descemetorhexis-in-descemet-membrane-endothelial-keratoplasty
#9
Adi Einan-Lifshitz, Nir Sorkin, Tanguy Boutin, Mahmood Showail, Armand Borovik, Murad Alobthani, Clara C Chan, David S Rootman
PURPOSE: To introduce a novel method to perform descemetorhexis in Descemet membrane endothelial keratoplasty (DMEK) using the femtosecond laser and to compare it with Descemet membrane endothelial keratoplasty performed with manual descemetorhexis (M-DMEK). METHODS: A retrospective medical chart review of 2 groups of patients who underwent DMEK surgery combined with cataract surgery secondary to Fuchs corneal endothelial dystrophy and cataract: 17 patients underwent femtosecond laser-enabled descemetorhexis Descemet membrane endothelial keratoplasty (FE-DMEK) and 89 patients underwent DMEK surgery with M-DMEK...
July 2017: Cornea
https://www.readbyqxmd.com/read/28593180/surgical-management-of-spontaneous-late-onset-descemet-membrane-detachment-after-penetrating-keratoplasty-for-keratoconus-a-case-report
#10
Myrsini Petrelli, Konstantinos Oikonomakis, Konstantinos Andreanos, Andreas Mouchtouris, Ilias Georgalas, George Kymionis
BACKGROUND: To report a surgical method for treating corneal oedema in a case of late-onset Descemet membrane detachment after penetrating keratoplasty. CASE PRESENTATION: A 55-year old patient presented with sudden visual loss in his left eye 28 years after penetrating keratoplasty for keratoconus. Slit-lamp biomicroscopy revealed a distortion of the corneal graft anatomy with protrusion of the graft and peripheral thinning and steepening in the residual host tissue, accompanied by corneal graft oedema...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28586930/-mid-and-longterm-experiences-with-the-boston-keratoprosthesis-the-cologne-and-salzburg-perspective
#11
Friederike Schaub, Björn O Bachmann, Orang Seyeddain, Sarah Moussa, Herbert A Reitsamer, Claus Cursiefen
Background Eyes with severe corneal opacifications and insufficient prognosis for high-risk corneal transplantation can be considered for the implantation of a Boston-keratoprosthesis. Since 2013, this technique of "artificial" corneal replacement is provided to high-risk eyes at the Department of Ophthalmology, University of Cologne and for 9 years at the University of Salzburg. In the meantime, a type I Boston keratoprosthesis (BI-KPro) has been implanted in 24 eyes in Cologne and in 28 eyes in Salzburg. Methods In this article, results and complications according to BI-KPro are discussed, both from the literature in PubMed, as well as from our own experiences...
June 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28586928/-biomaterials-or-donor-tissue-what-is-the-future-of-tissue-engenieering-for-cornea-reconstruction
#12
Björn O Bachmann, Stefan Schrader
For the replacement of corneal tissue, corneal grafts or amniotic membrane are still used as a standard material. Since this is biological tissue, there is only a limited standardization regarding preparation, tissue properties and behaviour after transplantation. In addition, there is a risk of disease transmission, and the availability of both human corneas and amniotic membrane is insufficient in many regions of the world, which is why alternative biomaterials have been explored for many years now. Among the natural biomaterials, materials based on collagen or keratin provide characteristics that make them good candidates for corneal tissue replacement...
June 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28582374/management-of-corneal-scarring-secondary-to-herpes-zoster-keratitis
#13
Omar M Hassan, Asim V Farooq, Ketki Soin, Ali R Djalilian, Joshua H Hou
PURPOSE: To review the management of visually significant corneal scarring secondary to herpes zoster keratitis (HZK). METHODS: Literature review. RESULTS: Management options for visually significant corneal scarring secondary to HZK include scleral contact lenses, photorefractive or phototherapeutic keratectomy, lamellar keratoplasty, penetrating keratoplasty, and keratoprosthesis. Many authors recommend tarsorrhaphy in at-risk patients at the time of corneal transplantation...
June 2, 2017: Cornea
https://www.readbyqxmd.com/read/28579539/preparation-of-acellular-scaffold-for-corneal-tissue-engineering-by-supercritical-carbon-dioxide-extraction-technology
#14
Yi-Hsun Huang, Fan-Wei Tseng, Wen-Hsin Chang, I-Chen Peng, Dar-Jen Hsieh, Shu-Wei Wu, Ming-Long Yeh
In this study, we developed a novel method using supercritical carbon dioxide (SCCO2) to prepare acellular porcine cornea (APC). Under gentle extraction conditions using SCCO2 technology, hematoxylin and eosin staining showed that cells were completely lysed, and cell debris, including nuclei, was efficiently removed from the porcine cornea. The SCCO2-treated corneas exhibited intact stromal structures and appropriate mechanical properties. Moreover, no immunological reactions and neovascularization were observed after lamellar keratoplasty in rabbits...
June 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28575918/-expansion-and-transplantation-of-limbal-stem-cells-for-corneal-surface-regeneration
#15
Adrian Gericke, Joanna Wasielica-Poslednik, Marion Zimmermann, Aytan Musayeva
In humans, regeneration of the corneal epithelium is regulated by the stem cell reservoir of the limbus. After extensive limbal damage, e.g., by inflammation, thermal burn or chemical injury, limbal stem cell deficiency leading to vascularization and opacification of the cornea and resulting in vision loss, may develop. Several techniques of autologous and allogenic stem cell transplantation have been established. The limbus can be restored by transplantation of whole limbal grafts, small limbal biopsies or by ex vivo-expanded limbal cells...
June 2, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28574139/visual-outcomes-following-descemet-stripping-automated-endothelial-keratoplasty-for-corneal-endothelial-dysfunction
#16
Oualid Guechi, Louis Lhuillier, Naila Houmad, Christophe Goetz, Nadia Ouamara, Jean Marc Perone
OBJECTIVE: To assess objective and subjective visual outcomes achieved by patients with corneal endothelial dysfunction who have undergone surgical treatment with Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: A total of 40 eyes of 36 patients with corneal endothelial dysfunction underwent DSAEK. All were followed up for 1 year. Visual acuity (VA; logMAR), mean endothelial cell density (MCD; via noncontact specular microscopy), and topography assessment were performed at baseline (preoperatively)...
April 10, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28570404/surrogate-outcome-measures-for-corneal-neurotization-in-infants-and-children
#17
Sarvnaz Sepehripour, Mark Sheldon Lloyd, Hiroshi Nishikawa, Bruce Richard, Manoj Parulekar
BACKGROUND: Corneal anesthesia is a rare and challenging condition, particularly in young children. The insensate cornea leads to abnormal epithelial cell metabolism and loss of trophic influences supplied by the corneal nerve fibers. This results in recurrent spontaneous epithelia erosion and eventual loss of sight. Corneal reinnervation is a definitive treatment option for neuropathic keratitis. The outcome measures in young children following corneal sensitization are different to adults as esthesiometry is unachievable...
May 31, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28567165/letter-to-the-editor-corneoscleral-melt-50-years-after-excision-of-pterygium
#18
Aki Kondo, Tatsuya Mimura, Mari Goto, Yuko Kamei, Saito Yusuke, Hiroko Okuma, Masao Matsubara
PURPOSE: To report a case of corneoscleral melt that occurred 50 years after resection of pterygium with postoperative administration of mitomycin C (MMC). RESULTS: A 93-year-old woman developed acute corneal perforation and scleral melt in her left eye at 50 years after pterygium surgery with postoperative topical MMC. She underwent limbal transplantation. The anterior chamber reformed postoperatively and her intraocular pressure was normal. At 12 months after transplantation, best-corrected visual acuity was 20/500 and the graft-host junction was well apposed...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28559289/generating-minicorneal-organoids-from-human-induced-pluripotent-stem-cells
#19
Praveen Joseph Susaimanickam, Savitri Maddileti, Vinay Kumar, Sreedhar Rao Boyinpally, Ramavat Ravinder Naik, Milind N Naik, Geereddy Bhanuprakash Reddy, Virender Singh Sangwan, Indumathi Mariappan
Corneal epithelial stem cells residing within the annular limbal crypts regulate adult tissue homeostasis. Autologous limbal grafts and tissue engineered corneal epithelial cell sheets have been widely used in the treatment of various ocular surface defects. In case of bilateral limbal defects, pluripotent stem cell (PSC) derived corneal epithelial cells are now being explored as an alternative to allogeneic limbal grafts. We report here an efficient method to generate complex three dimensional corneal organoids from human PSCs...
May 30, 2017: Development
https://www.readbyqxmd.com/read/28556252/traumatic-globe-rupture-after-deep-anterior-lamellar-keratoplasty-a-novel-management-technique
#20
Miltiadis Fiorentzis, Sebastian Bäurle, Anja Viestenz, Berthold Seitz, Arne Viestenz
BACKGROUND: A traumatic wound dehiscence can occur many years after surgery in 2-6% of all keratoplasties. Intraocular tissue prolapse can lead to severe visual loss. Deep anterior lamellar keratoplasty (DALK) leads to higher wound stability because of the intact Descemet membrane. We report a case of a novel management of wound dehiscence following DALK. METHODS: A 59-year-old patient underwent uncomplicated DALK for advanced keratoconus. Eighteen months later he experienced a traumatic wound dehiscence (globe rupture) after a fall...
May 27, 2017: Clinical Anatomy
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