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Corneal graft

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https://www.readbyqxmd.com/read/29027064/light-scattering-measurements-in-electron-beam-sterilized-corneas-stored-in-recombinant-human-serum-albumin
#1
Khoa D Tran, Yan Li, Jeffrey D Holiman, Maolong Tang, David Huang, Michael D Straiko, Christopher G Stoeger
Irradiated corneal tissues have been used for a variety of ophthalmic procedures including glaucoma drainage device covers and lamellar grafts. The maintenance of corneal clarity is important, as light obstructions resulting from processing or long-term storage of irradiated corneas may negatively affect vision and postoperative cosmesis. It has been reported that corneal tissues can be preserved in human serum albumin (HSA), however, the clarity of corneas after long-term storage in HSA has not been well described...
October 12, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29023237/corneal-tissue-from-dry-eye-donors-leads-to-enhanced-graft-rejection
#2
Takenori Inomata, Jing Hua, Takeshi Nakao, Tina Shiang, Homer Chiang, Afsaneh Amouzegar, Reza Dana
PURPOSE: To assess the effect of dry eye disease (DED) in graft donors on dendritic cell (DC) maturation, host T-cell sensitization, and corneal allograft rejection. METHODS: Corneas of control (healthy donor) and DED mice (C57BL/6) were transplanted onto fully allogeneic naive BALB/c recipients (n = 10 mice/group). Long-term allograft survival was evaluated for 8 weeks. Corneas and draining lymph nodes (dLNs) were harvested at posttransplantation day 14 (n = 5 mice/group)...
October 10, 2017: Cornea
https://www.readbyqxmd.com/read/28992804/surface-modification-of-model-hydrogel-contact-lenses-with-hyaluronic-acid-via-thiol-ene-click-chemistry-for-enhancing-surface-characteristics
#3
Myrto Korogiannaki, Jianfeng Zhang, Heather Sheardown
Discontinuation of contact lens wear as a result of ocular dryness and discomfort is extremely common; as many as 26% of contact lens wearers discontinue use within the first year. While patients are generally satisfied with conventional hydrogel lenses, improving on-eye comfort continues to remain a goal. Surface modification with a biomimetic, ocular friendly hydrophilic layer of a wetting agent is hypothesized to improve the interfacial interactions of the contact lens with the ocular surface. In this work, the synthesis and characterization of poly(2-hydroxyethyl methacrylate) surfaces grafted with a hydrophilic layer of hyaluronic acid are described...
October 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28990995/donor-tissue-preparation-for-descemet-membrane-endothelial-keratoplasty-an-updated-review
#4
Rénuka S Birbal, Shameema Sikder, Jessica T Lie, Esther A Groeneveld-van Beek, Silke Oellerich, Gerrit R J Melles
PURPOSE: To provide an overview of the current literature on donor tissue preparation for Descemet membrane endothelial keratoplasty (DMEK). METHODS: A comprehensive database search without date restrictions was performed in PubMed and in The Cochrane Library in May, 2017. Keywords included Descemet membrane endothelial keratoplasty, corneal transplantation, graft, harvest, dissection, preparation, endothelial cell, and endothelial cell density. Articles aiming to describe or evaluate a technique for DMEK graft preparation were considered eligible and were included in this review...
October 5, 2017: Cornea
https://www.readbyqxmd.com/read/28990426/gene-therapy-for-modulation-of-t-cell-mediated-immune-response-provoked-by-corneal-transplantation
#5
Marko Pastak, Veronika Kleff, Daniel Raphael Saban, Marta Czugala, Klaus-Peter Steuhl, Süleyman Ergün, Bernhard Singer, Thomas Armin Fuchsluger
Corneal transplantation (=keratoplasty) is the most common type of tissue replacement in the world. The increased rate of graft rejection after keratoplasty is a central problem for repeated transplantations and in inflamed host corneas. It has been shown that apoptosis of grafted epithelium has a role in corneal allograft rejection. Our study focused on the T cell response triggered in BALB/c mice after allogeneic corneal transplantation with and without anti-apoptotic p35-transduced epithelium. To restrict p35 expression to the epithelial cells we created modified allogeneic composite grafts...
October 7, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28988187/changes-in-uk-ophthalmology-surgical-training-analysis-of-cumulative-surgical-experience-2009-2015
#6
Jeremy Hoffman, Fiona Spencer, Daniel Ezra, Alexander C Day
OBJECTIVE: To investigate changes in the patterns of cumulative surgical experience for ophthalmologists in the UK following the introduction of a new national training scheme. DESIGN: Retrospective review of all surgical training records submitted to the UK Royal College of Ophthalmologists by trainees for the award of Certificate of Completion of Training (CCT) for the period 2009-2015. SETTING: Secondary level care, UK. PARTICIPANTS: 539 trainees achieving CCT over the 7-year study period...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28985815/young-donor-graft-assisted-endothelial-keratoplasty-pdek-dmek-with-epithelial-debridement-for-chronic-pseudophakic-bullous-keratopathy
#7
Amar Agarwal, Priya Narang, Dhivya A Kumar, Ashvin Agarwal
OBJECTIVE: The aim of this study was to describe the applicability and report visual outcomes for the treatment of subepithelial fibrosis and anterior stromal scarring in cases of chronic pseudophakic bullous keratopathy (PBK) with epithelial debridement and endothelial keratoplasty (EK) (pre-Descemet endothelial keratoplasty [PDEK]; Descemet membrane endothelial keratoplasty [(DMEK]) using young donor tissue. DESIGN: Prospective, single-centre, interventional study...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28982949/the-existence-of-dead-cells-in-donor-corneal-endothelium-preserved-with-storage-media
#8
Koji Kitazawa, Tsutomu Inatomi, Hidetoshi Tanioka, Satoshi Kawasaki, Hiroko Nakagawa, Osamu Hieda, Hideki Fukuoka, Naoki Okumura, Noriko Koizumi, Bernie Iliakis, Chie Sotozono, Shigeru Kinoshita
AIM: To investigate the viability of donor corneal endothelial cells (CECs) preserved in storage media by histological examination. METHODS: Twenty-eight donor corneas were obtained from SightLife Eye Bank (Seattle, Washington), and redundant peripheral portions of those corneas were used for histological examination after removal of the centre corneal graft for transplantation. To assess cell viability in the corneal endothelium, biostaining experiments were performed using propidium iodide, calcein-AM, Hoechst 33 342, annexin V, anti-vimentin antibody and toluidine blue...
October 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28977017/real-time-assessment-of-corneal-endothelial-cell-damage-following-graft-preparation-and-donor-insertion-for-dmek
#9
Maninder Bhogal, Chan N Lwin, Xin-Yi Seah, Elavazhagan Murugan, Khadijah Adnan, Shu-Jun Lin, Gary Peh, Jodhbir S Mehta
PURPOSE: To establish a method for assessing graft viability, in-vivo, following corneal transplantation. METHODS: Optimization of calcein AM fluorescence and toxicity assessment was performed in cultured human corneal endothelial cells and ex-vivo corneal tissue. Descemet membrane endothelial keratoplasty grafts were incubated with calcein AM and imaged pre and post preparation, and in-situ after insertion and unfolding in a pig eye model. Global, macroscopic images of the entire graft and individual cell resolution could be attained by altering the magnification of a clinical confocal scanning laser microscope...
2017: PloS One
https://www.readbyqxmd.com/read/28976416/learning-dmek-from-youtube
#10
Hamish D McKee, Vishal Jhanji
PURPOSE: To evaluate the outcomes of the first cases of Descemet membrane endothelial keratoplasty (DMEK) performed by an anterior segment surgeon, learning the procedure, including graft preparation, primarily from watching YouTube videos. DMEK surgery was not learned during fellowship training; there was no attendance at DMEK courses, no witnessing of live surgery, and no supervision by an experienced DMEK surgeon. All graft tissue was prepared by the surgeon on the day of surgery. METHODS: This is a retrospective review of the 3-month postoperative results of the first 40 consecutive cases...
October 2, 2017: Cornea
https://www.readbyqxmd.com/read/28976415/amniotic-membrane-grafts-to-reduce-pterygium-recurrence
#11
Ronald Rosen
PURPOSE: To demonstrate the long-term outcome of pterygium surgery with adjunctive amniotic membrane transplantation (AMT) and intraoperative mitomycin C (MMC) in a large case series. METHODS: Medical records were retrieved for this noncomparative retrospective study of all patients who had pterygium excision with adjunctive AMT and intraoperative MMC, from October 2010 to June 2016 with at least 6 months of follow-up. RESULTS: There were a total of 556 eyes of 535 patients (291 males and 244 females) with average age of 51...
October 2, 2017: Cornea
https://www.readbyqxmd.com/read/28974839/phacoemulsification-after-penetrating-keratoplasty-due-war-injury-at-young-adult
#12
Emir Cabric, Vahid Jusufovic, Nizama Salihefendic, Amra Nadarevic Vodencarevic
INTRODUCTION: It is known that phacoemulsification of cataracts after penetrating keratoplasty there are always some difficulties and of course a higher rate of different intraoperative complications. Phacoemulsification after PK may cause significant endothelial injury and affect long term graft survival. AIM: The aim of this report is to describe one of these cases and the possible ways to manage them. CASE REPORT: We report a case o of a 31-year-old female patient, with a cataract on her left eye...
June 2017: Medical Archives
https://www.readbyqxmd.com/read/28971253/-block-excision-with-tectonic-corneoscleral-graft-for-traumatic-pediatric-epithelial-implantation-cysts
#13
G Avgitidou, L M Heindl, C Cursiefen
Invasion of corneal epithelium into the anterior chamber can arise after ocular surgery or penetrating injury. This is extremly rare with an incidence of 0-0.2%. Three different types can be distiguished: cystic, diffuse and mixed form. Only cystic epithelial invasion can be treated with a curative therapeutic option that is blockexzision with tectonic corneoscleral transplantation.
September 29, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28969610/associated-factors-diagnosis-and-management-of-acanthamoeba-keratitis-in-a-referral-center-in-southern-china
#14
Jing Zhong, Xingyi Li, Yuqing Deng, Ling Chen, Shiyou Zhou, Weilan Huang, Shiqi Lin, Jin Yuan
BACKGROUND: To analyse the associated factors, diagnosis, clinical manifestations and therapeutic effects of Acanthamoeba keratitis at a tertiary ophthalmic centre in Southern China. METHODS: A retrospective clinical study was performed in fifteen patients who were admitted to Zhongshan Ophthalmic Centre (ZOC) from January 2004 to December 2014. The patients' pathogenesis-associated factors were analysed, and preoperative diagnoses were determined using corneal scraping cultures and/or confocal microscopy followed...
October 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28969525/rekeratoplasty-for-the-correction-of-refractive-status-due-to-post-lasik-donor-graft
#15
Ayse Yagci, Melis Palamar, Ozlem Barut Selver, Banu Yaman
We report a case of cataract-combined penetrating keratoplasty that required rekeratoplasty for refractive status because of the inadvertent use of a cornea from a donor who had undergone LASIK surgery. The case presents the use of perioperative visualization, anterior segment optic coherence tomography, and histopathologic confirmation. A 63-year-old female patient with leukoma and cataract in the left eye underwent combined cataract surgery and penetrating keratoplasty. During surgery, a jelly-like layer extending a few millimeters in diameter was observed around the lenticule...
September 30, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28968295/descemet-membrane-endothelial-transfer-ultimate-outcome
#16
Rénuka S Birbal, Jack Parker, Martin Dirisamer, Ana Janićijević, Lamis Baydoun, Isabel Dapena, Gerrit R J Melles
PURPOSE: To evaluate the clinical outcome of 16 eyes undergoing Descemet membrane endothelial transfer (DMET). METHODS: In this retrospective cohort study, a consecutive series of 16 eyes from 16 patients was evaluated after subtotal detachment of the Descemet graft after a Descemet membrane endothelial keratoplasty procedure (n = 8) or intended DMET (n = 8) for either Fuchs endothelial dystrophy (n = 10) or bullous keratopathy (BK; n = 6). RESULTS: All 8 Descemet membrane endothelial keratoplasty procedures were complicated by subtotal detachment of the donor graft...
September 29, 2017: Cornea
https://www.readbyqxmd.com/read/28968294/surface-modifications-of-the-pmma-optic-of-a-keratoprosthesis-to-improve-biointegration
#17
Andri K Riau, Subbu S Venkatraman, Claes H Dohlman, Jodhbir S Mehta
Biointegration of a keratoprosthesis (KPro) is critical for the mitigation of various long-term postoperative complications. Biointegration of a KPro occurs between the haptic skirt (corneal graft) and the central optic [poly(methyl methacrylate) (PMMA)]. Various studies have highlighted common problems associated with poor bonding and biointegration between these 2 incompatible biomaterials. Resolution of these issues could be achieved by surface modification of the inert material (PMMA). A calcium phosphate (CaP) coating deposited on dopamine-activated PMMA sheets by simulated body fluid incubation (d-CaP coating) was shown to improve adhesion to collagen type I (main component of corneal stroma) compared with untreated PMMA and PMMA with other surface modifications...
November 2017: Cornea
https://www.readbyqxmd.com/read/28959505/update-on-the-management-of-high-risk-penetrating-keratoplasty
#18
Sayena Jabbehdari, Alireza Baradaran Rafii, Ghasem Yazdanpanah, Pedram Hamrah, Edward J Holland, Ali R Djalilian
PURPOSE OF REVIEW: In this article, we review the indications and latest management of high-risk penetrating keratoplasty. RECENT FINDINGS: Despite the immune-privilege status of the cornea, immune-mediated graft rejection still remains the leading cause of corneal graft failure. This is particularly a problem in the high-risk graft recipients, namely patients with previous graft failure due to rejection and those with inflamed and vascularized corneal beds. A number of strategies including both local and systemic immunosuppression are currently used to increase the success rate of high-risk corneal grafts...
March 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28951784/intrastromal-corneal-ring-segments-for-astigmatism-correction-after-deep-anterior-lamellar-keratoplasty
#19
Júlio C D Arantes, Sandro Coscarelli, Paulo Ferrara, Luana P N Araújo, Marcos Ávila, Leonardo Torquetti
Background. To evaluate the change in corneal astigmatism after intrastromal corneal ring segment (ICRS) implantation in keratoconus patients with previous deep anterior lamellar keratoplasty (DALK). Design was a longitudinal, retrospective, interventional study. The study included 25 eyes of 24 patients with keratoconus who had DALK performed at least two years prior to ICRS implantation. All patients had a clear corneal graft with up to 8.00 D of corneal astigmatism and intolerance to contact lenses. The studied parameters were age, sex, corrected distance visual acuity (CDVA), maximum keratometry (K1), minimum keratometry (K2), spherical equivalent, and astigmatism...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28947445/a-study-protocol-for-a-multicentre-randomised-clinical-trial-evaluating-the-safety-and-feasibility-of-a-bioengineered-human-allogeneic-nanostructured-anterior-cornea-in-patients-with-advanced-corneal-trophic-ulcers-refractory-to-conventional-treatment
#20
Miguel González-Andrades, Rosario Mata, María Del Carmen González-Gallardo, Santiago Medialdea, Salvador Arias-Santiago, Juliana Martínez-Atienza, Antonio Ruiz-García, Lorena Pérez-Fajardo, Antonio Lizana-Moreno, Ingrid Garzón, Antonio Campos, Miguel Alaminos, Gloria Carmona, Natividad Cuende
INTRODUCTION: There is a need to find alternatives to the use of human donor corneas in transplants because of the limited availability of donor organs, the incidence of graft complications, as well as the inability to successfully perform corneal transplant in patients presenting limbal deficiency, neo-vascularized or thin corneas, etc. We have designed a clinical trial to test a nanostructured fibrin-agarose corneal substitute combining allogeneic cells that mimics the anterior human native cornea in terms of optical, mechanical and biological behaviour...
September 24, 2017: BMJ Open
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