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Corneal graft

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https://www.readbyqxmd.com/read/29661447/chronological-factors-of-the-process-of-donation-and-classification-of-corneal-tissue
#1
G K P Cruz, M A Ferreira Júnior, S Balbino da Silva, I C de Azevedo, V E P Santos, M L Ivo
INTRODUCTION: The quality of corneal tissue is influenced by several factors inherent to the recipient, donor, donation process, and transplantation that may primarily or secondarily interfere in the survival of a corneal graft. OBJECTIVE: The objective of this study was to identify the factors inherent to the donation process, specifically related to the harvesting and processing of tissue and to the donor, that may interfere with the quality of corneal tissue...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29658389/comparison-of-endoscopic-assisted-and-temporary-keratoprosthesis-assisted-vitrectomy-in-combat-ocular-trauma-experience-at-a-tertiary-eye-center-in-turkey
#2
Onder Ayyildiz, Ali Hakan Durukan
Objective This study was performed to compare the functional and anatomical results of endoscopic-assisted and temporary keratoprosthesis (TKP)-assisted vitrectomy in patients with combat ocular trauma (COT). Methods The medical records of 14 severely injured eyes of 12 patients who underwent endoscopy or TKP implantation in combination with vitreoretinal surgery from 2007 to 2015 were retrospectively evaluated. The patients' ocular history and functional and anatomic anterior and posterior segment results were analyzed...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29658366/a-novel-case-using-femtosecond-laser-acquired-lenticule-for-recurrent-pterygium-case-report-and-literature-review
#3
Om Prakash Pant, Ji-Long Hao, Dan-Dan Zhou, Fan Wang, Cheng-Wei Lu
Small incision lenticule extraction (SMILE) is a minimally invasive, safe and flapless femtosecond laser technique used mainly to correct myopia through extraction of a corneal lenticule. Lenticules obtained in this way are transparent and of high quality, and thus, can be used to treat other corneal diseases. A 65-year-old male patient presented with recurrent pterygium complicated by thin cornea. The patient was treated surgically using a SMILE-extracted lenticule to avoid further complications and to maintain eyeball integrity...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29649838/-limbokeratoplasty-to-treat-lattice-and-granular-corneal-dystrophies
#4
Thabo Lapp, Philip Maier, Daniel Böhringer, Thomas Reinhard
The surgical technique of limbokeratoplasty (limbo-KP) was initially established for the treatment of severe limbal deficiencies. Besides improving visual acuity, surgery is aimed at ensuring complete, long-lasting epithelialization of the ocular surface. Due to the extension of the indication spectrum, limbo-KPs are also used in various forms of epithelial/stromal corneal dystrophies such as lattice and granular (transforming growth factor beta-induced [TGFBI] gene mutation associated) dystrophies. The objective of limbo-KP is to ensure prolonged clear graft survival without a recurrence of the dystrophy as otherwise observed after conventional keratoplasty...
April 12, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29643797/uneventful-anterior-migration-of-intravitreal-ozurdex-implant-in-a-patient-with-iris-sutured-intraocular-lens-and-descemet-stripping-automated-endothelial-keratoplasty
#5
Andleeb Zafar, Ioannis M Aslanides, Vasileios Selimis, Konstantinos I Tsoulnaras, David Tabibian, George D Kymionis
Purpose: We report here the case of a patient with anterior segment migration of intravitreal dexamethasone implant as well as its management and outcome. Methods: The patient had the following sequence of events: complicated cataract surgery, iris-sutured intraocular lens implant, followed by cystoid macular edema treated with intravitreal Avastin, retinal vein occlusion treated with intravitreal dexamethasone implant, corneal decompensation treated with Descemet stripping automated endothelial keratoplasty (DSAEK), and finally recurrence of macular edema treated with repeated intravitreal dexamethasone implant...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29627599/improving-the-practicality-and-safety-of-artificial-corneas-pre-assembly-and-gamma-rays-sterilization-of-the-boston-keratoprosthesis
#6
Miguel Gonzalez-Andrades, Roholah Sharifi, Mohammad-Mirazul Islam, Thibaut Divoux, Michael Haist, Eleftherios Paschalis, Larisa Gelfand, Shamina Mamodaly, Luca Di Cecilia, Andrea Cruzat, Franz-Josef Ulm, James Chodosh, Francois Delori, Claes H Dohlman
PURPOSE: To make the Boston keratoprosthesis (B-KPro), together with its carrier corneal graft, more easily procured, transported and stored, as well as less expensive, easier for the surgeon to implant and safer for the patient, it is proposed that the B-KPro-graft combination be pre-assembled by an expert technician, followed by sterilization with gamma ray irradiation (GI) allowing long-term storage at room temperature. For this to be possible, it must be shown that the B-KPro itself (not only the graft) remains unharmed by the irradiation...
April 5, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29625489/visualizing-the-fate-of-transplanted-k14-confetti-corneal-epithelia-in-a-mouse-model-of-limbal-stem-cell-deficiency
#7
Alexander Richardson, Mijeong Park, Stephanie L Watson, Denis Wakefield, Nick Di Girolamo
Purpose: Therapies for limbal stem cell deficiency (LSCD) include stem cell (SC) grafts that regenerate the damaged ocular surface. However, the fate of transplanted cells is ill-defined. We addressed this limitation using primary corneal epithelial cells from K14-Confetti mice. Methods: Cultures of primary corneo-limbal epithelia were generated from K14-Confetti (n = 6) and wild-type (WT) (n = 3) mice. Cell phenotype and function was ascertained by immunofluorescence, flow cytometry, quantitative PCR and colony formation...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29621372/outcomes-from-lateral-eyelid-coupling-for-facial-paralysis-using-the-modified-tarsoconjunctival-flap
#8
Raj Dedhia, Tsung-Yen Hsieh, Oliver Chin, Taha Z Shipchandler, Travis T Tollefson
Importance: In the setting of facial paralysis, inadequate eyelid closure and lower eyelid ectropion can lead to corneal exposure and impaired quality of life. Repair of paralytic ectropion is challenging, and an ideal surgical approach for all cases has not been identified. Objective: To assess the patient-reported outcomes and eyelid position improvement in patients with flaccid facial paralysis undergoing lateral eyelid coupling with a tarsal strip canthoplasty and modified tarsoconjunctival flap to correct eyelid malposition...
April 5, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29607856/hybrid-contact-lenses-for-visual-management-of-patients-after-keratoplasty
#9
Y Altay, O Balta, A Burcu, F Ornek
Aim: This study aims to report the outcomes of new-generation hybrid contact lenses for visual rehabilitation of postkeratoplasty patients. Materials and Methods: Twenty eyes of twenty postkeratoplasty patients were fitted with hybrid lenses. Each patient's keratometric values, ocular surface irregularity indices, central corneal thickness (CCT), uncorrected visual acuity (UCVA), spectacle-corrected visual acuity, contact lens-corrected visual acuity, contact lens fitting data, and contact lens daily wearing time were recorded...
April 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29602717/skin-xenotransplantation-historical-review-and-clinical-potential
#10
REVIEW
Takayuki Yamamoto, Hayato Iwase, Timothy W King, Hidetaka Hara, David K C Cooper
Half a million patients in the USA alone require treatment for burns annually. Following an extensive burn, it may not be possible to provide sufficient autografts in a single setting. Pig skin xenografts may provide temporary coverage. However, preformed xenoreactive antibodies in the human recipient activate complement, and thus result in rapid rejection of the graft. Because burn patients usually have some degree of immune dysfunction and are therefore at increased risk of infection, immunosuppressive therapy is undesirable...
March 27, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29601363/outcomes-of-trabeculectomy-and-glaucoma-drainage-devices-for-elevated-intraocular-pressure-after-penetrating-keratoplasty
#11
Mehmet Yakin, Umit Eksioglu, Zuleyha Yalniz-Akkaya, Selma Uzman, Evin Singar-Ozdemir, Kemal Gultekin, Gulizar Demirok, Ilgaz Yalvac, Firdevs Ornek, Ayse Burcu
PURPOSE: To assess and compare the outcomes of trabeculectomy with and without antimetabolites (AMs) and glaucoma drainage devices (GDDs) in the management of elevated intraocular pressure (IOP) after penetrating keratoplasty (PK). METHODS: Data of 84 eyes of 81 patients who underwent trabeculectomy (12 eyes without an AM and 42 eyes with an AM) or GDD implantation (30 eyes) after PK were reviewed retrospectively. The main outcome measures were IOP control, corneal graft survival, and postoperative ocular complications...
March 28, 2018: Cornea
https://www.readbyqxmd.com/read/29595764/use-of-donor-corneas-from-pseudophakic-eyes-for-descemet-membrane-endothelial-keratoplasty
#12
Thabo Lapp, Sonja Heinzelmann, Daniel Böhringer, Philipp Eberwein, Thomas Reinhard, Philip Maier
PURPOSE: The prevalence of pseudophakia increases with age and affects more than 30% of people older than 80 years. Because grafts from older donors seem to be more suitable for Descemet membrane endothelial keratoplasty (DMEK) surgery rather than grafts from younger donors, eye bank technicians and corneal surgeons have to deal with corneas from pseudophakic donors for DMEK graft preparation. However, graft preparation from corneas of pseudophakic donors can be more complicated. METHODS: We retrospectively analyzed our donor registry for the prevalence of pseudophakia...
March 27, 2018: Cornea
https://www.readbyqxmd.com/read/29595762/transplantation-blues-inadvertent-staining-of-amyloid-deposits-with-trypan-blue
#13
Agathe Marcon, Nicolas Périllat, Thibaud Garcin, Rémy Jullienne, Zhiguo He, Fabien Forest, Anne Sophie Gauthier, Philippe Gain, Gilles Thuret
PURPOSE: To describe inadvertent persistent staining of stromal amyloid deposits by trypan blue (TB) after penetrating keratoplasty (PK) and Descemet membrane endothelial keratoplasty (DMEK) performed in patients with corneal amyloidosis. METHODS: Case series of patients with corneal amyloidosis in whom intraoperative TB was used. RESULTS: One patient, hospitalized for acute rejection 6 weeks after DMEK, presented with an intense blue staining of small, spindle-shaped structures in the anterior half of the cornea...
March 27, 2018: Cornea
https://www.readbyqxmd.com/read/29579837/corneal-donor-profile-and-evolution-of-corneal-donation-in-a-brazilian-state-where-the-number-of-individuals-on-the-waiting-list-reached-zero-but-increased-again
#14
L S M Freitas, P C Rocon, A V de Almeida, R G N Erlacher, F M Paro
BACKGROUND: In most countries, the amount of corneal graft tissue available for transplantation is insufficient to meet demand. In 2010, there were 459 patients on the waiting list for corneal transplantation (WLCT) in Espirito Santo (ES), a Brazilian state with 3,885,000 inhabitants. Several strategies were implemented to reduce the number of individuals on the WLCT, which reached zero in 2011. Studies on the evolution of corneal donation contribute to reducing the WLCT worldwide. The aim of this study was to describe the evolution of corneal donation in ES and the profile of corneal donors from 2010 to 2013...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29577100/lagophthalmos-caused-by-cicatricial-adhesion-of-orbital-adipose-tissue-to-orbital-roof-a-case-report
#15
Yoshiyuki Kitaguchi, Jacqueline Mupas-Uy, Yasuhiro Takahashi, Hirohiko Kakizaki
Purpose: To report a case of lagophthalmos caused by cicatricial adhesion of orbital adipose tissue to the orbital roof. Observations: A 23-year-old female was presented with right lagophthalmos. Five months prior to consult at our clinic, she suffered from a penetrating trauma to the frontal lobe of the brain through the right orbital roof with cerebrospinal fluid leakage. Decompressive craniectomy was performed immediately after the injury using a coronal incision, which was followed by reconstruction with an artificial bone 1 month later...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29576892/amniotic-membrane-transplantation-in-surgical-treatment-of-conjunctival-melanoma-long-term-results
#16
Melis Palamar, Banu Yaman, Taner Akalın, Ayse Yağcı
Objectives: To investigate the long-term efficacy and results of surgical management of conjunctival melanoma reconstructed with amniotic membrane transplantation. Materials and Methods: Conjunctival melanoma in 10 patients (5 female, 5 male) was totally excised with adjunctive cryotherapy to the surgical margins, corneal epitheliectomy with absolute alcohol in cases of corneal involvement, lamellar sclerectomy in cases with episcleral involvement, and ocular surface grafting with cryopreserved amniotic membrane...
February 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29576879/the-balance-of-th1-th2-and-lap-tregs-th17-cells-is-crucial-for-graft-survival-in-allogeneic-corneal-transplantation
#17
Shang Li, Jing Yu, Chungang Guo, Ying Jie, Zhiqiang Pan
Purpose: CD4+LAP+ T cells are newly discovered regulatory T cells (Tregs). The aim of this study is to investigate the balance of Th1/Th2 and LAP+Tregs/Th17 in mice after allogeneic corneal transplantation. Methods: A total of 65 mice received orthotopic penetrating transplantation. According to the survival scores of the grafts, the mice were divided into the rejection group and the survival group 3 weeks after transplantation. Th1, Th2, Th17, and regulatory T cells in the ipsilateral drainage lymph nodes and spleens were measured with flow cytometry...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29572107/reduced-efficacy-of-low-dose-topical-steroids-in-dry-eye-disease-associated-with-graft-versus-host-disease
#18
Jia Yin, Ahmad Kheirkhah, Thomas Dohlman, Ujwala Saboo, Reza Dana
PURPOSE: To compare the response of dry eye disease (DED) to treatment with topical steroid in patients with and without graft-versus-host disease (GVHD). DESIGN: Post-hoc analysis of a double-masked, randomized clinical trial. METHODS: This single-center study included 42 patients with moderate to severe DED associated with (N=21) or without (N=21) chronic GVHD. In each group, patients received either loteprednol etabonate 0.5% ophthalmic suspension or artificial tears twice daily for 4 weeks...
March 20, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29567793/corneal-transplant-follow-up-study-ii-ctfs-ii-a-prospective-clinical-trial-to-determine-the-influence-of-hla-class-ii-matching-on-corneal-transplant-rejection-baseline-donor-and-recipient-characteristics
#19
W John Armitage, Helen L Winton, Mark N A Jones, Julie M Crewe, Chris A Rogers, Derek M Tole, Andrew D Dick
PURPOSE: To describe a study to determine the influence of HLA class II matching on allograft rejection of high-risk, full-thickness corneal transplants. METHODS: A prospective, longitudinal, clinical trial (ISRCTN25094892) with a primary outcome measure of time to first clinically determined rejection episode. Tissue typing used DNA-based techniques. Corneas were allocated to patients with ≤2 human leucocyte antigen (HLA) class I antigen mismatches by cohort minimisation to achieve 0, 1 or 2 HLA class II (HLA-DR) antigen mismatches...
March 22, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29563700/fungal-keratitis-and-endophthalmitis-after-implantation-of-type-1-keratoprosthesis
#20
Chintan Malhotra, Arun Kumar Jain, Nikhil Aggarwal
A 70-year-old patient who underwent uneventful primary implantation of Auro K Pro (a Type I Boston Keratoprosthesis-based device), developed infiltrates in the deep stroma of the carrier corneal graft and exudates on the optic stem of the keratoprosthesis assembly, 6 weeks postoperatively, which subsequently progressed to endophthalmitis. Vitreous tap was positive for a panfungal polymerase chain reaction, although corneal scrapings for both Gram stain and KOH wet mount yielded negative results. Aggressive management with systemic, topical, intravitreal, and intrastromal antifungal agents resulted in an initial resolution, but residual inflammatory vitreous membranes persisted...
January 2018: Oman Journal of Ophthalmology
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