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https://www.readbyqxmd.com/read/28101705/tyrosine-kinase-inhibitors-and-proton-pump-inhibitors-an-evaluation-of-treatment-options
#1
Roelof W F van Leeuwen, Frank G A Jansman, Nicole G Hunfeld, Robert Peric, Anna K L Reyners, Alex L T Imholz, Jacobus R B J Brouwers, Joachim G Aerts, Teun van Gelder, Ron H J Mathijssen
Tyrosine kinase inhibitors (TKIs) have rapidly become an established factor in oncology, and have been shown to be effective in a wide variety of solid and hematologic malignancies. Use of the oral administration route of TKIs offers flexibility and is convenient for the patient; however, despite these advantages, the oral route of administration also causes a highly relevant new problem. Acid-inhibitory drugs, such as proton pump inhibitors (PPIs), increase the intragastric pH, which may subsequently decrease TKI solubility, bioavailability, and treatment efficacy...
January 18, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28100719/testing-for-departure-from-uniformity-and-estimating-mean-direction-for-circular-data
#2
Graeme D Ruxton
Although circular data are common in biological studies, the analysis of such data is often more rudimentary than it need be. One of the most common hypotheses tested is whether the data suggest that samples are clustered around a certain specified direction, rather than being uniformly spread across all possible directions. Here, I use data from a recent publication on the compass directions of epiphytes and mistletoes on tree trunks. This is used to demonstrate how with relatively little extra work researchers can improve the rigour of testing such hypotheses, and this improved rigour can lead to biological insights missed by simpler analyses...
January 2017: Biology Letters
https://www.readbyqxmd.com/read/28097527/breast-cancer-screening-and-social-media-a-content-analysis-of-evidence-use-and-guideline-opinions-on-twitter
#3
Anthony Nastasi, Tyler Bryant, Joseph K Canner, Mark Dredze, Melissa S Camp, Neeraja Nagarajan
There is ongoing debate regarding the best mammography screening practices. Twitter has become a powerful tool for disseminating medical news and fostering healthcare conversations; however, little work has been done examining these conversations in the context of how users are sharing evidence and discussing current guidelines for breast cancer screening. To characterize the Twitter conversation on mammography and assess the quality of evidence used as well as opinions regarding current screening guidelines, individual tweets using mammography-related hashtags were prospectively pulled from Twitter from 5 November 2015 to 11 December 2015...
January 17, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28096666/barriers-and-facilitators-influencing-self-management-among-copd-patients-a-mixed-methods-exploration-in-primary-and-affiliated-specialist-care
#4
Chantal F Hillebregt, Auke J Vlonk, Marc A Bruijnzeels, Onno Cp van Schayck, Niels H Chavannes
Self-management is becoming increasingly important in COPD health care although it remains difficult to embed self-management into routine clinical care. The implementation of self-management is understood as a complex interaction at the level of patient, health care provider (HCP), and health system. Nonetheless there is still a poor understanding of the barriers and effective facilitators. Comprehension of these determinants can have significant implications in optimizing self-management implementation and give further directions for the development of self-management interventions...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28093134/management-of-clostridium-difficile-infection-in-inflammatory-bowel-disease-expert-review-from-the-clinical-practice-updates-committee-of-the-aga-institute
#5
REVIEW
Sahil Khanna, Andrea Shin, Ciarán P Kelly
The purpose of this expert review is to synthesize the existing evidence on the management of Clostridium difficile infection in patients with underlying inflammatory bowel disease. The evidence reviewed in this article is a summation of relevant scientific publications, expert opinion statements, and current practice guidelines. This review is a summary of expert opinion in the field without a formal systematic review of evidence. Best Practice Advice 1: Clinicians should test patients who present with a flare of underlying inflammatory bowel disease for Clostridium difficile infection...
February 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28088203/a-3-arm-randomised-controlled-trial-of-communicating-healthy-beginnings-advice-by-telephone-chat-to-mothers-with-infants-to-prevent-childhood-obesity
#6
Li Ming Wen, Chris Rissel, Louise A Baur, Alison J Hayes, Huilan Xu, Anna Whelan, Myna Hua, Miranda Shaw, Philayrath Phongsavan
BACKGROUND: With an increasing prevalence of obesity in young children globally, there is an urgent need for the development of effective early interventions. A previous Healthy Beginnings Trial using a nurse-led home visiting program has demonstrated that providing mothers with evidence-based advice can improve maternal practice regarding obesity prevention, and can reduce Body Mass Index (BMI) in the first few years of life. However, the costs for scale-up of home visiting limit its population reach...
January 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28087054/care-pathway-of-patients-with-metastatic-pancreatic-cancer-in-daily-practice-in-france-results-from-the-repere-national-survey
#7
Pascal Hammel, Romain Coriat, Gérard Lledo, Mariella de Bausset, Marion Selosse, Stéphane Obled, Franck Bonnetain
Data in the literature regarding the care pathway of pancreatic cancer patients are limited. The objective of the REPERE survey was to identify and describe the initial stages of the care pathway of pancreatic patients in the metastatic phase. From May to October 2015, 62 oncologists (ON) or gastroenterologists specialized in digestive oncology (GESDO) and 300 general practitioners (GP) completed an electronic questionnaire on the pathway of 728 patients recently diagnosed with metastatic pancreatic adenocarcinoma...
January 10, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28077609/travellers-and-influenza-risks-and-prevention
#8
REVIEW
M Goeijenbier, P van Genderen, B J Ward, A Wilder-Smith, R Steffen, A D M E Osterhaus
BACKGROUND: Influenza viruses are among the major causes of serious human respiratory tract infection worldwide. In line with the high disease burden attributable to influenza, these viruses play an important, but often neglected, role in travel medicine. Guidelines and recommendations regarding prevention and management of influenza in travellers are scarce. Of special interest for travel medicine are risk populations and also circumstances that facilitate influenza virus transmission and spread, like travel by airplane or cruise ship and mass gatherings...
January 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28074570/development-of-the-sbirt-checklist-for-observation-in-real-time-score
#9
Janice A Vendetti, Bonnie G McRee, Frances K Del Boca
BACKGROUND AND AIMS: Screening, Brief Intervention and Referral to Treatment (SBIRT) programs have been implemented widely in medical settings, with little attention focused on how well providers adhere to evidence-based service delivery in everyday practice. The purposes of this paper were to: (1) introduce a flexible, relatively simple methodology, the SBIRT Checklist for Observation in Real-time (SCORe), to assess adherence to evidence-based practice and provide preliminary evidence supporting its criterion validity; and (2) illustrate the feasibility and potential utility of the SCORe by analyzing observations of providers within four large-scale SBIRT programs in the United States...
February 2017: Addiction
https://www.readbyqxmd.com/read/28071967/tobacco-cessation-counseling-within-physical-therapist-practice-results-of-a-statewide-survey-of-florida-physical-therapists
#10
Rose M Pignataro
INTRODUCTION: Tobacco use is the leading preventable risk factor for chronic disease, disability, and premature mortality. People with disabilities experience higher tobacco use and reduced access to services when compared with the general population. The negative impact on treatment outcomes across all practice settings provides a strong incentive for physical therapists (PTs) to engage in tobacco cessation counseling (TCC). METHODS: Prevalence of TCC and barriers toward implementation was explored using an anonymous cross-sectional survey of Florida-licensed PTs...
January 10, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28071331/clinical-encounters-of-australian-general-practice-registrars-with-paediatric-patients
#11
Harriet Hiscock, Gary Freed, Simon Morgan, Amanda Tapley, Elizabeth Holliday, Andrew Davey, Jean Ball, Mieke van Driel, Neil Spike, Lawrie McArthur, Parker Magin
BACKGROUND: Whether general practitioner (GP) registrars have adequate exposure to, and feel confident in, managing children's health during training is unknown. OBJECTIVES: To determine the prevalence and associations of GP registrars' paediatric vs. non-paediatric consultations. METHODS: Cross-sectional analysis from a cohort study of Australian GP registrars' 2010-2014 consultations. RESULTS: 889 registrars contributed details for 26,427 (21...
January 10, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28070884/a-national-survey-of-neurological-monitoring-practice-after-obstetric-regional-anaesthesia-in-the-uk
#12
E Roderick, J Hoyle, S M Yentis
Neuraxial anaesthesia is widely used in obstetrics and neurological complications are rare. However, when they occur, subsequent investigation and management are time-critical and correlate with the extent of neurological recovery. The Third National Audit Project recommended the implementation of guidelines in obstetric epidural management, including advice on monitoring for early signs of problems and acting upon concerns. However, no national guideline exists for postoperative management in the obstetric population...
January 10, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28068558/targeted-next-generation-sequencing-of-the-entire-vitamin-d-receptor-gene-reveals-polymorphisms-correlated-with-vitamin-d-deficiency-among-older-filipino-women-with-and-without-fragility-fracture
#13
Mark Pretzel Zumaraga, Paul Julius Medina, Juan Miguel Recto, Lauro Abrahan, Edelyn Azurin, Celeste C Tanchoco, Cecilia A Jimeno, Cynthia Palmes-Saloma
This study aimed to discover genetic variants in the entire 101 kB vitamin D receptor (VDR) gene for vitamin D deficiency in a group of postmenopausal Filipino women using targeted next generation sequencing (TNGS) approach in a case-control study design. A total of 50 women with and without osteoporotic fracture seen at the Philippine Orthopedic Center were included. Blood samples were collected for determination of serum vitamin D, calcium, phosphorus, glucose, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase and as primary source for targeted VDR gene sequencing using the Ion Torrent Personal Genome Machine...
December 21, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28064290/referral-of-pregnant-women-to-dentists-and-advice-for-dental-visit-by-medical-nurses
#14
S Sharif, N Saddki, A Yusoff
OBJECTIVE: Dental attendance among pregnant women has been low although they frequently experience oral health problems. Nurses who provide antenatal health care are well positioned to advise and refer their pregnant patients to dentists. this study aimed to assess the practices of medical nurses regarding advice for dental visits and referral of their pregnant patients to dentists. METHODS: A total of 202 medical nurses who provide antenatal health care at Ministry of Health facilities in the district of Kota bharu, Kelantan, Malaysia were included in this cross-sectional study...
October 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28062200/individual-behavioural-and-home-environmental-factors-associated-with-eating-behaviours-in-young-adolescents
#15
Natalie Pearson, Paula Griffiths, Stuart J H Biddle, Julie P Johnston, Emma Haycraft
This study aimed to examine individual, behavioural and home environmental factors associated with frequency of consumption of fruit, vegetables and energy-dense snacks among adolescents. Adolescents aged 11-12 years (n = 521, 48% boys) completed a paper-based questionnaire during class-time which included a Food Frequency Questionnaire assessing their consumption of fruit, vegetables, and energy-dense (ED) snacks, and items assessing habits, self-efficacy, eating at the television (TV), eating with parents, parenting practices, and home availability and accessibility of foods...
January 3, 2017: Appetite
https://www.readbyqxmd.com/read/28061521/quality-of-life-after-surgical-treatment-for-esophageal-atresia-long-term-outcome-of-154-patients
#16
Alice Catherine Hölscher, Michael Laschat, Vera Choinitzki, Nadine Zwink, Ekkehart Jenetzky, Oliver Münsterer, Ralf Kurz, Marcus Pauly, Ulrike Brokmeier, Andreas Leutner, Benno Ure, Martin Lacher, Johannes Schumacher, Heiko Reutter, Thomas Michael Boemers
Background The short- and long-term surgical results in patients with esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) have been described in depth from a physician's perspective. Contrarily, the perception and coping strategies of affected patients and their parents have rarely been reported. The aim of this study was to generate data on this matter. Patients and Methods A total of 154 patients who had operative reconstruction for EA between 1971 and 2012 were evaluated for demographic data, surgical technique, affection of daily life, and coping strategies...
January 6, 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28055574/guidelines-for-the-detection-of-rickettsia-spp
#17
Aránzazu Portillo, Rita de Sousa, Sonia Santibáñez, Ana Duarte, Sophie Edouard, Isabel P Fonseca, Cátia Marques, Marketa Novakova, Ana M Palomar, Marcos Santos, Cornelia Silaghi, Laura Tomassone, Sara Zúquete, José A Oteo
The genus Rickettsia (Rickettsiales: Rickettsiaceae) includes Gram-negative, small, obligate intracellular, nonmotile, pleomorphic coccobacilli bacteria transmitted by arthropods. Some of them cause human and probably also animal disease (life threatening in some patients). In these guidelines, we give clinical practice advices (microscopy, serology, molecular tools, and culture) for the microbiological study of these microorganisms in clinical samples. Since in our environment rickettsioses are mainly transmitted by ticks, practical information for the identification of these arthropods and for the study of Rickettsia infections in ticks has also been added...
January 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28053553/hepatitis-c-in-egypt-past-present-and-future
#18
REVIEW
Ahmed Elgharably, Asmaa I Gomaa, Mary Me Crossey, Peter J Norsworthy, Imam Waked, Simon D Taylor-Robinson
Hepatitis C viral infection is endemic in Egypt with the highest prevalence rate in the world. It is widely accepted that the implementation of mass population antischistosomal treatment involving administration of tartar emetic injections (from 1950s to 1980s) led to widespread infection. What is less well known, however, is that these schemes were implemented by the Egyptian Ministry of Health on the advice of the World Health Organization. There has been a spectrum of treatments to target the public health disaster represented by the hepatitis C problem in Egypt: from the use of PEGylated interferon to the recent use of direct acting antiviral drugs...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28049471/reported-bed-net-ownership-and-use-in-social-contacts-is-associated-with-uptake-of-bed-nets-for-malaria-prevention-in-pregnant-women-in-ghana
#19
Kacey C Ernst, Steven Erly, Charity Adusei, Melanie L Bell, David Komla Kessie, Alberta Biritwum-Nyarko, John Ehiri
BACKGROUND: Despite progress made in the last decades, malaria persists as a pressing health issue in sub-Saharan Africa. Pregnant women are particularly vulnerable to infection and serious health outcomes for themselves and their unborn child. Risk can be mitigated through appropriate use of control measures such as insecticide-treated bed nets. Although social networks can influence uptake of preventive strategies, the role of social influence on bed net ownership has not been explored...
January 4, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28045199/yoga-for-improving-health-related-quality-of-life-mental-health-and-cancer-related-symptoms-in-women-diagnosed-with-breast-cancer
#20
REVIEW
Holger Cramer, Romy Lauche, Petra Klose, Silke Lange, Jost Langhorst, Gustav J Dobos
BACKGROUND: Breast cancer is the cancer most frequently diagnosed in women worldwide. Even though survival rates are continually increasing, breast cancer is often associated with long-term psychological distress, chronic pain, fatigue and impaired quality of life. Yoga comprises advice for an ethical lifestyle, spiritual practice, physical activity, breathing exercises and meditation. It is a complementary therapy that is commonly recommended for breast cancer-related impairments and has been shown to improve physical and mental health in people with different cancer types...
January 3, 2017: Cochrane Database of Systematic Reviews
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