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S Francque, N Lanthier, L Verbeke, H Reynaert, C Van Steenkiste, L Vonghia, W J Kwanten, J Weyler, E Trépo, D Cassiman, F Smets, M Komuta, A Driessen, E Dirinck, E Danse, B Op de Beeck, E van Craenenbroeck, Y Van Nieuwenhove, G Hubens, A Geerts, C Moreno
Non-Alcoholic Fatty Liver Disease (NAFLD) is highly prevalent and associated with considerable liver-related and non-liverrelated morbidity and mortality. There is, however, a lot of uncertainty on how to handle NAFLD in clinical practice. The current guidance document, compiled under the aegis of the Belgian Association for the Study of the Liver by a panel of experts in NAFLD, from a broad range of different specialties, covers many questions encountered in daily clinical practice regarding diagnosis, screening, therapy and follow-up in adult and paediatric patients...
January 2018: Acta Gastro-enterologica Belgica
D Franchimont, M Ferrante, E Louis, M De Vos, O Dewit, P Van Hootegem, T Moreels, C Liefferinckx, P Bossuyt, F Baert, J F Rahier, S Vermeire
No abstract text is available yet for this article.
January 2018: Acta Gastro-enterologica Belgica
Jennifer Abbasi
No abstract text is available yet for this article.
March 21, 2018: JAMA: the Journal of the American Medical Association
Nuno Damácio de Carvalho Félix, Natana de Morais Ramos, Maria Naiane Rolim Nascimento, Thereza Maria Magalhães Moreira, Célida Juliana de Oliveira
OBJECTIVE: To construct nursing diagnosis statements based on the International Classification for Nursing Practice (ICNP®) for people with metabolic syndrome, settled on the theoretical framework of Basic Human Needs. METHOD: Descriptive study developed in four stages: 1) Identification and validation of terms relevant to care with health priority; 2) Cross-mapping of the terms identified with ICNP® terms; 3) Construction of the nursing diagnosis statements; and 4) Cross-mapping of constructed statements with the ones in ICNP®...
2018: Revista Brasileira de Enfermagem
Jo Durham, Lisa Schubert, Lisa Vaughan, Cameron D Willis
BACKGROUND: Middle ear disease (otitis media) is endemic among Aboriginal and Torres Strait Islander children in Australia and represents an important cause of hearing loss. The disease is the result of a mix of biological, environmental and host risk factors that interact in complex, non-linear ways along a dynamic continuum. As such, it is generally recognised that a holistic, systems approach is required to reverse the high rates of otitis media in Aboriginal and Torres Strait Islander children...
2018: PloS One
Karen-Leigh Edward, Jo-Ann Giandinoto, Tracey J Weiland, Jennie Hutton, Sarah Reel
This study aimed to systematically review evidence to assess the efficacy of non-pharmacological brief interventions in the emergency department to reduce the incidence, severity and impact of acute behavioural disturbances. The literature search was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A total of 18 articles were identified as meeting the inclusion criteria and read in full. Following a full read and a consensus discussion, it was subsequently considered the studies chosen had not met the inclusion criteria...
March 22, 2018: British Journal of Nursing: BJN
Zipei Cao, Lijuan Wei, Weizhi Zhu, Xuping Yao
BACKGROUND: Reduction of cyclin-dependent kinase inhibitor 2A (CDKN2A) (p16 and p14) expression through DNA methylation has been reported in prostate cancer (PCa). This meta-analysis was conducted to assess the difference of p16 and p14 methylation between PCa and different histological types of nonmalignant controls and the correlation of p16 or p14 methylation with clinicopathological features of PCa. METHODS: According to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement criteria, articles were searched in PubMed, Embase, EBSCO, Wanfang, and CNKI databases...
March 2018: Medicine (Baltimore)
Wei Wang, Dong Xing, Yingjian Song, Feiyu Liu
BACKGROUND: Esophageal cancer is one of the worst malignant digestive neoplasms with poor treatment outcomes. Definitive concurrent chemoradiotherapy (CRT) has become the standard nonsurgical treatment option for locally advanced esophageal cancer. The chemotherapeutic drugs 5-fluorouracil and cisplatin have been most commonly used in CRT of esophageal cancer. However, radiotherapy combined with 5-FU/cisplatin often delivers severe toxicity to patients. S-1 as an oral chemotherapeutic drug exhibits higher anti-tumor activity, less adverse effects, and better biological availability...
March 2018: Medicine (Baltimore)
Afsane Bahrami, Hamidreza Bahrami-Taghanaki, Mozhgan Afkhamizadeh, Amir Avan, Zahra Mazloum Khorasani, Habibollah Esmaeili, Bahareh Amin, Samine Jazebi, Delaram Kamali, Gordon A Ferns, Hamid Reza Sadeghnia, Majid Ghayour-Mobarhan
There have been several studies evaluating the association between vitamin and mineral status and menstrual disturbance. In the present study, we aimed to assess the relationship between the menstrual bleeding pattern and premenstrual syndrome (PMS) symptoms with serum 25-hydroxyvitamin D, and calcium levels in adolescent girls. A cross-sectional study was carried out in 897 high school girls from northeastern Iran. The prevalence of hypocalcaemia, normal serum calcium and hypercalcaemia was 27.1, 59.8 and 13...
March 21, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Mary Lavelle, Jennifer Abthorpe, Thomas Simpson, Gabriel Reedy, Fiona Little, Anita Banerjee
The majority of maternal deaths in the UK are due to pre-existing or new-onset medical conditions, known as 'indirect deaths'. The MBRRACE report identified serious gaps in clinicians' human factors skills, including communication, leadership and teamwork, which contributed to maternal death. In response, we developed the first multi-disciplinary simulation-based training programme designed to address Medical Emergencies in Obstetrics (MEmO). Employing a mixed methods design, this study evaluated the educational impact of this training programme on the healthcare staff (n = 140), including the medical doctors (n = 91) and the midwives (n = 49)...
March 21, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Martina Larsson, Pollyanna Cohen, Gayle Hann, Sarah M Creighton, Deborah Hodes
This pilot study researched the attitudes towards and the knowledge of female genital mutilation (FGM) in adult women with FGM and their partners. The participant population consisted of English-speaking women and men over 18 years old attending specialist FGM clinics in two London hospitals. The participants completed a questionnaire on the attitudes and the knowledge of FGM, which were adapted with permission from the United Nations Children's Fund and the United States Agency for International Development household surveys...
March 21, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Simin Mirakhor Samani, Tahmineh Ezazi Bojnordi, Manijeh Zarghampour, Sobhan Merat, Daniel F Fouladi
Our objective was to examine the expression rates of p53, Bcl-2 and Bax in endometrial carcinoma, endometrial hyperplasia and normal endometrium. A total of 94 endometrial frozen sections (carcinoma 48, hyperplasia 21, normal tissue 25) were examined immunohistochemically in terms of the expression rates of p53, Bcl-2 and Bax. All of the specimens in the non-malignant groups were positive for Bax, whereas this rate was 85.4% in the group with malignant specimens (p = .03). Conversely, p53 was expressed only in the cancerous group (77...
March 21, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Fatma Yazici Yilmaz, Begum Aydogan Mathyk, Serhat Yildiz, Nefise Nazli Yenigul, Ceren Saglam
The purpose of this study was to compare postoperative pain and neuropathy after primary caesarean sections with either blunt or sharp fascial expansions. A total of 123 women undergoing primary caesarean sections were included in the study. The sharp group had 61 patients, and the blunt group had 62. In the sharp group, the fascia was incised sharply and extended using scissors. In blunt group, the fascia was bluntly opened by lateral finger-pulling. The primary outcome was postoperative pain. The long-term chronic pain scores were significantly lower in the blunt group during mobilisation (p = ...
March 21, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Alexander C Hollis, Edward T Davis
AIM: To assess the knowledge, attitudes and perceptions of orthopaedic patients towards participating in clinical trials (CTs). METHODS: A cross-sectional study was conducted on 200 adult orthopaedic patients at a Tertiary Orthopaedic Centre. Data was collected using a self-completed questionnaire. Statistical analysis was used to compare responses between those that would and would not participate using the chi-squared and the Mann-Whitney U testing. RESULTS: Eighty-four percent of the patients (n = 168) stated that they would be happy to participate in clinical trials research...
March 20, 2018: International Orthopaedics
Hashem B El-Serag, John Y Kao, Fasiha Kanwal, Mark Gilger, Frank LoVecchio, Steven F Moss, Sheila Crowe, Adam Elfant, Thomas Haas, Ron Hapke, David Y Graham
Despite guidelines for detection and treatment of Helicobacter pylori infection, recommendations to test patients before and after therapy are commonly not followed in the United States (US). At the Houston Consensus Conference, 11 experts on management of adult and pediatric patients with H pylori, from different geographic regions of the US, met to discuss key factors in diagnosis of H pylori infection, including identification of appropriate patients for testing, effects of antibiotic susceptibility on testing and treatment, appropriate methods for confirmation of infection and eradication, and relevant health system considerations...
March 17, 2018: Clinical Gastroenterology and Hepatology
(no author information available yet)
Imai H, Furukawa TA, Hayashi SU, et al. (2017) Risk perception, self-efficacy, trust for physician, depression, and behavior modification in diabetic patients. Journal of Health Psychology. E pub ahead of print 7 July 2017. DOI: 10.1177/1359105317718057. The author omitted to include one of the funders in the Funding statement. The online version of this article has been corrected. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from the Japan Agency for Medical Research and Development (Practical Research Project for Life-Style related Diseases including CVD and Diabetes), the Ministry of Health, Labour and Welfare of Japan (Strategic Outcomes Research Program for Research on Diabetes; Comprehensive Research on Life-Style Related Diseases including CVD and Diabetes H25-016), JSPS KAKENHI under Grant No...
March 1, 2018: Journal of Health Psychology
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Martha Kubik, Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Skin cancer is the most common type of cancer in the United States. Although invasive melanoma accounts for only 2% of all skin cancer cases, it is responsible for 80% of skin cancer deaths. Basal and squamous cell carcinoma, the 2 predominant types of nonmelanoma skin cancer, represent the vast majority of skin cancer cases. Objective: To update the 2012 US Preventive Services Task Force (USPSTF) recommendation on behavioral counseling for the primary prevention of skin cancer and the 2009 recommendation on screening for skin cancer with skin self-examination...
March 20, 2018: JAMA: the Journal of the American Medical Association
Robert Sidbury
No abstract text is available yet for this article.
March 20, 2018: JAMA Pediatrics
Kimberly S Chiew, Jordan Hashemi, Lee K Gans, Laura Lerebours, Nathaniel J Clement, Mai-Anh T Vu, Guillermo Sapiro, Nicole E Heller, R Alison Adcock
Volitional exploration and learning are key to adaptive behavior, yet their characterization remains a complex problem for cognitive science. Exploration has been posited as a mechanism by which motivation promotes memory, but this relationship is not well-understood, in part because novel stimuli that motivate exploration also reliably elicit changes in neuromodulatory brain systems that directly alter memory formation, via effects on neural plasticity. To deconfound interrelationships between motivation, exploration, and memory formation we manipulated motivational state prior to entering a spatial context, measured exploratory responses to the context and novel stimuli within it, and then examined motivation and exploration as predictors of memory outcomes...
2018: PloS One
Neill Storrar, David Hope, Helen Cameron
PURPOSE: Competency-based medical education (CBME) seeks to prepare undergraduate and postgraduate trainees for clinical practice. Its major emphasis is on outcomes, but questions about how best to reach these remain. One key issue is the need to integrate what matters most to students when setting educational goals: this is crucial if we are to design curricula that trainees understand and engage with, and that promote successful achievement of competencies. METHOD: We interviewed medical students in years 4 and 6 of a 6-year medical degree and used thematic analysis to understand their main educational priorities and how these fit with the aims of CBME...
March 20, 2018: Medical Teacher
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