Lora C Bailey-Downs, Laura G Sherlock, Michaela N Crossley, Aristides Rivera Negron, Paul T Pierce, Shirley Wang, Hua Zhong, Cynthia Carter, Kathryn Burge, Jeffrey V Eckert, Lynette K Rogers, Peter F Vitiello, Trent E Tipple
Extremely preterm infants are often treated with supraphysiological oxygen, which contributes to the development of bronchopulmonary dysplasia (BPD). These same infants exhibit compromised antioxidant capacities due in part to selenium (Se) deficiency. Se is essential for basal and inducible antioxidant responses. The present study utilized a perinatal Se deficiency (SeD) mouse model to identify the combined effects of newborn hyperoxia exposure and SeD on alveolarization and antioxidant responses, including the identification of affected developmental pathways...
March 25, 2024: Antioxidants (Basel, Switzerland)