Arpana Pandit, Hyung-Jin Kim, Gi-Su Oh, AiHua Shen, Su-Bin Lee, Dipendra Khadka, SeungHoon Lee, Hyeok Shim, Sei-Hoon Yang, Eun-Young Cho, Kang-Beom Kwon, Tae Hwan Kwak, Seong-Kyu Choe, Raekil Park, Hong-Seob So
Although cisplatin is a widely used anticancer drug for the treatment of a variety of tumors, its use is critically limited because of adverse effects such as ototoxicity, nephrotoxicity, neuropathy, and gastrointestinal damage. Cisplatin treatment increases oxidative stress biomarkers in the small intestine, which may induce apoptosis of epithelial cells and thereby elicit damage to the small intestine. Nicotinamide adenine dinucleotide (NAD(+)) is a cofactor for various enzymes associated with cellular homeostasis...
November 27, 2015: Biochemical and Biophysical Research Communications