Medeea Badii, Viola Klück, Orsolya Gaal, Georgiana Cabău, Ioana Hotea, Valentin Nica, Andreea M Mirea, Anca Bojan, Mihnea Zdrenghea, Hint Consortium, Boris Novakovic, Tony R Merriman, Zhaoli Liu, Yang Li, Cheng-Jian Xu, Crişan Pamfil, Simona Rednic, Radu A Popp, Tania O Crisan, Leo Ab Joosten
OBJECTIVE: Hyperuricaemia is necessary for gout. High urate concentrations have been linked to inflammation in mononuclear cells. Here, we explore the role of the suppressor of cytokine signaling 3 (SOCS3) in urate-induced inflammation. METHODS: Peripheral blood mononuclear cells (PBMCs) from gout patients, hyperuricemic and normouricemic individuals were cultured for 24h with varying concentrations of soluble urate, followed by 24h restimulation with lipopolysaccharides (LPS) ± monosodium urate (MSU) crystals...
February 1, 2024: Joint, Bone, Spine: Revue du Rhumatisme