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Aurélien Guffroy, Benjamin Dervieux, Simon Gravier, Camille Martinez, Joelle Deibener-Kaminsky, Eric Hachulla, Marc Michel, Jean-Christophe Weber, Anne-Sophie Korganow, Laurent Arnaud, Jacques-Eric Gottenberg, Jean Sibilia
OBJECTIVES: Systemic capillary leak syndrome (Clarkson's disease) is a rare entity characterized by recurrent and unpredictable attacks of capillary leakage of plasma fluid and proteins throughout the endothelium. Some cases are secondary. We describe the rare association between secondary capillary leak syndrome (SCLS) and autoimmune diseases. METHODS: We conducted a nationwide, retrospective, observational, and collaborative study throughout the hospital units of the Club des Rhumatismes et Inflammations network (CRI) between March and August 2015...
August 12, 2016: Seminars in Arthritis and Rheumatism
Alexis Régent, Serge Redeker, Alban Deroux, Pierre Kieffer, Kim Heang Ly, Maxime Dougados, Eric Liozon, Claire Larroche, Loïc Guillevin, Laurence Bouillet, Olivier Espitia, Nathalie Costedoat-Chalumeau, Martin Soubrier, Benoît Brihaye, François Lifermann, Guillaume Lefevre, Xavier Puéchal, Luc Mouthon, Eric Toussirot
OBJECTIVE: To report the efficacy and safety of tocilizumab (TCZ) for giant cell arteritis (GCA). METHODS: A retrospective multicenter study that included 34 patients receiving TCZ for GCA. RESULTS: TCZ was effective in all but 6 patients, who still had mild symptoms. Mean glucocorticoid dose was tapered. One patient died and 3 patients had to stop TCZ therapy because of severe adverse events. Twenty-three patients stopped treatment; 8 of these experienced relapses after a mean of 3...
August 2016: Journal of Rheumatology
F Danion, N Rosine, R Belkhir, J E Gottenberg, E Hachulla, E Chatelus, G Pugnet, Y M Pers, X Mariette, J Sibilia, R Seror
OBJECTIVE: The objective of this study was to assess the safety and efficacy of abatacept in patients with SLE refractory to conventional treatment in routine clinical practice. METHODS: This retrospective study included 11 SLE patients treated with abatacept for an active and refractory disease. The primary endpoint was the change in SLE Disease Activity Index (SLEDAI) score at six months. Response was defined as a decrease of SLEDAI ≥4 in a patient continuing abatacept...
March 24, 2016: Lupus
G Nocturne, A Virone, Wan-Fai Ng, V Le Guern, E Hachulla, D Cornec, C Daien, O Vittecoq, B Bienvenu, C Marcelli, D Wendling, Z Amoura, R Dhote, C Lavigne, R Fior, J E Gottenberg, R Seror, X Mariette
OBJECTIVE: To define parameters predictive of lymphoma development in patients with primary Sjögren's syndrome (SS). METHODS: A multicenter case-control survey was performed to identify predictors of lymphoma. Cases were patients who developed lymphoma after diagnosis of primary SS and were mainly recruited through the Club Rhumatismes et Inflammation network. For each case, 2 controls (matched for disease duration and age) were randomly selected among patients with primary SS and without lymphoma...
April 2016: Arthritis & Rheumatology
Alain Meyer, Guillaume Lefevre, Guillaume Bierry, Aurélie Duval, Sébastien Ottaviani, Olivier Meyer, Anne Tournadre, Benoit Le Goff, Laurent Messer, Anne Laure Buchdahl, Michel De Bandt, Christophe Deligny, Matthieu Dubois, Pascal Coquerelle, Géraldine Falgarone, René-Marc Flipo, Alexis Mathian, Bernard Geny, Zahir Amoura, Olivier Benveniste, Eric Hachulla, Jean Sibilia, Baptiste Hervier
Anticitrullinated peptide/protein antibodies (ACPA), which are highly specific for rheumatoid arthritis (RA), may be found in some patients with other systemic autoimmune diseases. The clinical significance of ACPA in patients with antisynthetase syndrome (ASS), a systemic disease characterized by the association of myositis, interstitial lung disease, polyarthralgia, and/or polyarthritis, has not yet been evaluated with regard to phenotype, prognosis, and response to treatment. ACPA-positive ASS patients were first identified among a French multicenter registry of patients with ASS...
May 2015: Medicine (Baltimore)
Manuelle Viguier, Stéphanie Rist, François Aubin, Marie-Thérèse Leccia, Marie-Aleth Richard, Marina Esposito-Farèse, Philippe Gaudin, Thao Pham, Pascal Richette, Daniel Wendling, Jean Sibilia, Florence Tubach
Patients with inflammatory rheumatisms, such as rheumatoid arthritis, are more prone to develop skin cancers than the general population, with an additional increased incidence when receiving TNF blockers. There is therefore a need that physicians treating patients affected with inflammatory rheumatisms with TNF blockers recognize malignant skin lesions, requiring an urgent referral to the dermatologist and a potential withdrawal or modification of the immunomodulatory treatment. We aimed to demonstrate that an online training dedicated to skin tumors increase the abilities of rheumatologists to discriminate skin cancers from benign skin tumors...
2015: PloS One
Dewi Guellec, Emilie Cornec-Le Gall, Matthieu Groh, Eric Hachulla, Alexandre Karras, Pierre Charles, Bertrand Dunogué, Sébastien Abad, Fernand Alvarez, Fréderic Gérard, Valérie Devauchelle-Pensec, Jacques-Olivier Pers, Xavier Puéchal, Loïc Guillevin, Alain Saraux, Divi Cornec
OBJECTIVES: To describe the clinical presentation, management and prognosis of patients diagnosed with both primary Sjögren's syndrome (pSS) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). METHODS: French nation-wide survey completed by a systematic literature review. RESULTS: This work identified 7 new cases of coexisting pSS and AAV: 2 microscopic polyangiitis (MPA), 2 granulomatosis with polyangiitis (GPA), 2 anti-myeloperoxidase (MPO)-ANCA renal-limited AAV, and 1 eosinophilic granulomatosis with polyangiitis (EGPA)...
August 2015: Autoimmunity Reviews
Hélène Bauer, Cécile Luxembourger, Jacques-Eric Gottenberg, Sophie Fournier, Florence Abravanel, Alain Cantagrel, Emmanuel Chatelus, Pascal Claudepierre, Christophe Hudry, Jacques Izopet, Sylvie Fabre, Guillaume Lefevre, Laurent Marguerie, Antoine Martin, Laurent Messer, Anna Molto, Béatrice Pallot-Prades, Yves-Marie Pers, Anne-Marie Roque-Afonso, Christian Roux, Christelle Sordet, Martin Soubrier, Claire Veissier, Daniel Wendling, Jean-Marie Péron, Jean Sibilia
The clinical presentation and outcome of hepatitis E virus (HEV) infection in inflammatory rheumatic diseases are unknown. We aimed to investigate the severity of acute HEV infection and the risk of chronic viral replication in patients with inflammatory arthritides treated with immunosuppressive drugs. All rheumatology and internal medicine practitioners belonging to the Club Rhumatismes et Inflammation in France were sent newsletters asking for reports of HEV infection and inflammatory arthritides. Baseline characteristics of patients and the course of HEV infection were retrospectively assessed by use of a standardized questionnaire...
April 2015: Medicine (Baltimore)
Linda Rossi-Semerano, Bruno Fautrel, Daniel Wendling, Eric Hachulla, Caroline Galeotti, Luca Semerano, Isabelle Touitou, Isabelle Koné-Paut
BACKGROUND: Despite their limited licensed indications, anti-interleukin-1 (anti-IL-1) agents are often used in clinical practice for an increasing number of auto-inflammatory diseases. We conducted a national cross-sectional observational study from January 2011 to January 2013 to record the off-label use of such agents in France. We aimed to estimate the off-label use of anti-IL-1 treatments in France, assess their efficacy in rare diseases, and increase the reporting of their possible side effects...
2015: Orphanet Journal of Rare Diseases
Alice Courties, Gilles Grateau, Peggy Philippe, René-Marc Flipo, Leonardo Astudillo, Bérengère Aubry-Rozier, Isabelle Fabreguet, Wafki Fahd, Olivier Fain, Pascal Guggenbuhl, Eric Hachulla, Thomas Papo, Christophe Richez, Jean Sibilia, Jacques Morel, Francis Berenbaum, Jérémie Sellam
BACKGROUND: In published case reports, tocilizumab (TCZ) has shown good efficacy for AA amyloidosis in almost all patients. We investigated the efficacy and safety of TCZ in AA amyloidosis in a multicentre study of unselected cases. METHODS: We e-mailed rheumatology and internal medicine departments in France, Switzerland and North Africa by using the Club Rhumatismes Inflammation (CRI) network and the French TCZ registry, Registry RoAcTEmra (REGATE), to gather data on consecutive patients with histologically proven AA amyloidosis who had received at least one TCZ infusion...
2015: Amyloid: the International Journal of Experimental and Clinical Investigation
Bernadette Ngo Nonga, Agnès Pasquet, Laurent De Kherkove, David Glineur, Frederic Debieve, Corinne Hubinont, Gebrine El Khoury, Philippe Noirhomme
BACKGROUND: Due to current medical improvements, more women with cardiac disease are being operated during pregnancy. Fetal loss has been found to be significant between 9-30% of them and the surgery is supposed to be done maximal in the first trimester. OBJECTIVES: The aim of this study was to report our experience with urgent cardiopulmonary bypass carried out in early pregnancy and to analyze factors that may influence fetal and maternal morbidity and mortality after surgery...
August 2013: Research in Cardiovascular Medicine
Guillaume Lefèvre, Alain Meyer, David Launay, Irène Machelart, Michel DeBandt, Julien Michaud, Anne Tournadre, Pascal Godmer, Jean-Emmanuel Kahn, Aurélie Behra-Marsac, Marie-Agnès Timsit, Nicolas Schleinitz, Daniel Wendling, Sylvie Melac-Ducamp, Philippe Boyer, Anne Peretz, Thierry Lequerré, Christophe Richez, Lidwine Stervinou-Wemeau, Sandrine Morell-Dubois, Marc Lambert, Sylvain Dubucquoi, Benoit Wallaert, Olivier Benveniste, René-Marc Flipo, Pierre-Yves Hatron, Jean Sibilia, Eric Hachulla, Baptiste Hervier
OBJECTIVE: The aim of this study was to determine the frequency and characteristics of antisynthetase syndrome (ASS) revealed by polyarthritis. METHODS: First we conducted a retrospective single-centre study to assess the frequency of ASS patients who presented with polyarthritis without pulmonary and/or muscle symptoms. Secondly, we conducted a larger, multicentre study in order to describe the clinical characteristics of these patients. Exclusion criteria were the presence of RF, the presence of ACPA and overlap with another CTD...
May 2015: Rheumatology
Marion Couderc, Jacques-Eric Gottenberg, Xavier Mariette, Bruno Pereira, Thomas Bardin, Alain Cantagrel, Bernard Combe, Maxime Dougados, René-Marc Flipo, Xavier Le Loët, Thierry Shaeverbeke, Philippe Ravaud, Martin Soubrier
OBJECTIVE: The response rate to many therapies for RA is lower in women. The aim of this study was to analyse the influence of gender on the response to rituximab (RTX) in patients with RA. METHODS: A total of 1709 RA patients were included in the French Autoimmunity and Rituximab (AIR) registry. Disease activity assessed by the 28-joint DAS (DAS28) was recorded at baseline and at follow-up (6, 12, 18 and 24 months). Response criteria [European League Against Rheumatism (EULAR) remission defined as a DAS28 < 2...
October 2014: Rheumatology
Séverine Guillaume-Czitrom
No abstract text is available yet for this article.
February 2014: Joint, Bone, Spine: Revue du Rhumatisme
Arsène Mekinian, Thorsten Braun, Olivier Decaux, Géraldine Falgarone, Eric Toussirot, Loic Raffray, Mohamed Omouri, Bruno Gombert, Benoit De Wazieres, Anne-Laure Buchdaul, Jean-Marc Ziza, David Launay, Guillaume Denis, Serge Madaule, Christian Rose, Eric Grignano, Pierre Fenaux, Olivier Fain
We describe the characteristics and outcome of inflammatory arthritis in patients with myelodysplastic syndrome (MDS) in a French multicenter retrospective study. Twenty-two patients with MDS (median age, 77.5 yr [interquartile range, 69-81]; 10 women) were included. Inflammatory arthritis presented as polyarthritis in 17 cases (77%) and with symmetric involvement in 15 cases (68%). At diagnosis, the median disease activity score 28 based on C-reactive protein (DAS28-CRP) was 4.5 [2-6.5]. Two patients had anti-citrullinated protein antibodies (ACPAs), and 1 had radiologic erosions...
January 2014: Medicine (Baltimore)
Vincent Goëb, Marc Ardizzone, Laurent Arnaud, Jérôme Avouac, Athan Baillet, Alexandre Belot, Béatrice Bouvard, Pascal Coquerelle, Sabrina Dadoun, Alain Diguet, David Launay, Danielle Lebouc, Pierre Loulergue, Sophie Mahy, Pascal Mestat, Gaël Mouterde, Benjamin Terrier, Coralie Varoquier, Mathieu Verdet, Xavier Puéchal, Jean Sibilia
The use of TNFα antagonists must follow specific guidelines to ensure optimal effectiveness and safety. The French Society for Rheumatology (SFR) and Task Force on Inflammatory Joint Diseases (CRI), in partnership with several French learned societies, asked the French National Authority for Health (HAS) to develop and endorse good practice guidelines for the prescription and monitoring of TNFα antagonist therapy by physicians belonging to various specialties. These guidelines were developed, then, validated by two multidisciplinary panels of experts based on an exhaustive review of the recent literature and in compliance with the methodological rules set forth by the HAS...
December 2013: Joint, Bone, Spine: Revue du Rhumatisme
Noémie Abisror, Arsene Mekinian, Christian Lavigne, Marie-Anne Vandenhende, Michael Soussan, Olivier Fain
BACKGROUND/PURPOSE: The aim of this study is to analyze the efficacy and tolerance of tocilizumab in patients with Takayasu arteritis (TA). METHODS: We retrospectively studied patients with TA (ACR and/or Ishikawa's criteria): 5 French multicenter cases and 39 from the literature. Clinical, biological, radiological disease activity and treatment were analyzed before tocilizumab, during the follow-up and at the last available visit. RESULTS: Forty-four patients (median age 26years [3-65];) were included in the present study: 5 patients from the 3 French university hospitals and 39 cases from the literature review...
October 2013: Autoimmunity Reviews
Raphaèle Seror, Christophe Richez, Christelle Sordet, Stéphanie Rist, Laure Gossec, Guillaume Direz, Eric Houvenagel, Jean-Marie Berthelot, Christian Pagnoux, Emmanuelle Dernis, Sylvie Melac-Ducamp, Beatrice Bouvard, Caroline Asquier, Antoine Martin, Xavier Puechal, Xavier Mariette
OBJECTIVE: To determine the pattern of demyelinating disorders (DDs) occurring during anti-TNF-α therapy. METHODS: Between June 2005 and April 2008, 1800 French rheumatologists and internists were contacted to report cases of DDs occurring in patients treated with anti-TNF-α. RESULTS: After a median of 10.2 (1.5-39.9) months of treatment, 33 patients developed DDs: 22 had CNS and 11 peripheral nervous system (PNS) involvement. Underlying diseases were RA (n = 16), AS (n = 11), PsA (n = 4), JIA (n = 1) and PM (n = 1)...
May 2013: Rheumatology
Jacques-Eric Gottenberg, Gael Cinquetti, Claire Larroche, Bernard Combe, Eric Hachulla, Olivier Meyer, Edouard Pertuiset, Guy Kaplanski, Laurent Chiche, Jean-Marie Berthelot, Bruno Gombert, Philippe Goupille, Christian Marcelli, Séverine Feuillet, Jean Leone, Jean Sibilia, Charles Zarnitsky, Philippe Carli, Stephanie Rist, Philippe Gaudin, Carine Salliot, Muriel Piperno, Adeline Deplas, Maxime Breban, Thierry Lequerre, Pascal Richette, Charles Ghiringhelli, Mohamed Hamidou, Philippe Ravaud, Xavier Mariette
OBJECTIVES: To evaluate the efficacy and safety of rituximab in patients with primary Sjögren's syndrome (pSS). METHODS: The AutoImmune and Rituximab registry has included 86 patients with pSS treated with rituximab, prospectivey followed up every 6 months for 5 years. RESULTS: Seventy-eight patients with pSS (11 men, 67 women), who already had at least one follow-up visit, were analysed. Median age was 59.8 years (29-83), median duration of disease was 11...
June 2013: Annals of the Rheumatic Diseases
Cecilia Giampietro, Meriem Ridene, Thierry Lequerre, Nathalie Costedoat Chalumeau, Zahir Amoura, Jérémie Sellam, Jean Sibilia, Pierre Bourgeois, Bruno Fautrel
OBJECTIVE: Anakinra is effective in adult-onset Still's disease (AOSD) in the short term, but little is known regarding its efficacy over the long term. Our objective was to assess the long-term efficacy and safety of anakinra in AOSD. METHODS: A nationwide survey was conducted between 2009 and 2010 to identify AOSD patients treated with anakinra. Collected data consisted of disease characteristics at diagnosis and at medication onset; anakinra efficacy, safety, and dose adaptation; and reasons for discontinuation, if applicable...
May 2013: Arthritis Care & Research
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