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https://www.readbyqxmd.com/read/29595864/etiology-of-chronic-skin-lesions-in-subjects-with-peripheral-arterial-disease
#1
G Chisari, E M Chisari, A M Borzì, A Grasso, C G Chisari
INTRODUCTION: Skin lesions can be defined as lesions that result in loss of tissues and their joints, and often this cutaneous skin process is a primary or secondary consequence of the structural changes in the skin itself. Subjects with peripheral arteripathies that develop chronic skin lesions in the lower extremities of the Western world are constantly increasing. We conducted a study on the etiologic incidence of chronic skin lesions in peripheral arterial disease CSLpa subjects in the lower limbs compared to subjects with chronic skin lesions CSL (controls)...
March 2018: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29577863/hepatic-elimination-of-drugs-in-gestational-diabetes
#2
Claudio Daniel Gonzalez, Jorge Alvarinas, Ricardo Bolanos, Guillermo Di Girolamo
BACKGROUND: The liver is the major metabolic clearance organ for chemical agents from the human body. Pregnancy is associated with several physiological changes that may affect one or more of these factors, and also induces changes in the hepatic clearance of certain drugs.The aim of this paper was to review some of the currently available information in the field to provide some insights about the relevance of these changes on the clearance of some drugs. METHODS: A comprehensive literature search was carried out to identify eligible studies from MEDLINE/PubMed, EMBASE and SCIELO databases through 1970 first semester...
March 25, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29509996/the-relationship-between-mucosal-damage-in-celiac-disease-and-the-risk-of-neurological-and-psychiatric-conditions-is-much-more-complex-than-previously-thought
#3
EDITORIAL
P Parisi
No abstract text is available yet for this article.
June 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29221588/eau-thermale-d%C3%A2-av%C3%A3-ne-et-dermatite-atopique-av%C3%A3-ne%C3%A2-s-thermal-water-and-atopic-dermatitis
#4
D Guerrero, E Garrigue
Atopic dermatitis (AD) is the most frequent disease treated at the Avène hydrotherapy center. Children represent a large part of the population due to the high prevalence of AD in early childhood. Avène thermal spring water (ATSW) has been known for its therapeutic effects since the middle of the 18th century. It has been greatly studied over the last decades, with a comprehensive fundamental, pharmaco-clinical and clinical approach. Cohort studies using the Scoring Atopic Dermatitis (SCORAD) clinical score and the Dermatology Life Quality Index (DLQI) or the Children's Dermatology Life Quality Index [CDLQI]) quality of life scores, allowed to confirm the clinical results obtained from the previous studies...
January 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29165098/effects-of-olive-oil-on-tnf-%C3%AE-and-il-6-in-humans-implication-in-obesity-and-frailty
#5
Nagendra S Yarla, Angela Polito, Ilaria Peluso
BACKGROUND AND OBJECTIVE: Tumor necrosis factor-alpha (TNF)-α and interleukin (IL)-6 are important mediators of chronic low-grade systemic inflammation. The latter plays a central role in several obesity-related pathologies, such as diabetes, metabolic syndrome and cardiovascular diseases. Besides, these cytokines have been also implicated in geriatric and cancer-induced anorexia, cachexia, sarcopenia and frailty. Potential interventions for both obesity and frailty include dietary advice and nutraceuticals...
2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29137880/microbioma-and-probiotics-from-gut-to-mars
#6
EDITORIAL
Bruno Acatauassú Paes Barreto
No abstract text is available yet for this article.
October 27, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29055387/the-colon-revisited-or-the-key-to-wellness-health-and-disease
#7
C A Gonzalez-Correa, E Mulett-Vásquez, D A Miranda, C H Gonzalez-Correa, P A Gómez-Buitrago
The hypothesis being advanced in this paper is that there is a new medical paradigm emerging from the biomedical research carried out in this century, mainly due to the explosion of the so called "omics" and associated techniques. The main idea is that there is a common pathway from wellbeing and health to chronic disease ("chronopathy") and even to death, which comprises following steps: 1) unhealthy diet, sedentary life style and permanent exposition to xenobiotics and all kinds of noxious stimuli;→2) intestinal dysbiosis;→3) alteration of the intestinal mucus layer (especially that of the colon);→4) disruption of the endothelial tight junctions;→5) metabolic endotoxemia+bacterial translocation;→6) inflammation;→7) exacerbation of the enteric nervous system (ENS) and consequent maladaptation and malfunctioning of the colon;→8) epigenetic manifestations;→9) "chronopathy" and premature death...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28913337/new-insights-into-the-pathogenesis-of-celiac-disease
#8
REVIEW
Valli De Re, Raffaella Magris, Renato Cannizzaro
Celiac disease (CD) is an autoimmune and multisystem gluten-related disorder that causes symptoms involving the gastrointestinal tract and other organs. Pathogenesis of CD is only partially known. It had been established that ingestion of gluten proteins present in wheat and other cereals are necessary for the disease and develops in individuals genetically predisposed carrying the DQ2 or DQ8 human leukocyte antigen haplotypes. In this review, we had pay specific attention on the last discoveries regarding the three cellular components mainly involved in the development and maintenance of CD: T-cells, B-cells, and microbioma...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28795339/impact-of-nasopharyngeal-microbiota-on-the-development-of-respiratory-tract-diseases
#9
REVIEW
S Esposito, N Principi
Knowledge of whether and how respiratory microbiota composition can prime the immune system and provide colonisation resistance, limiting consecutive pathobiont overgrowth and infections, is essential to improving the prevention and therapy of respiratory disorders. Modulation of dysbiotic ecosystems or reconstitution of missing microbes might be a possible measure to reduce respiratory diseases. The aim of this review is to analyse the role of nasopharyngeal microbiota in the development of respiratory tract disease in paediatric-age subjects...
January 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28691459/periodontal-microbioma-and-rheumatoid-arthritis-the-role-of-porhyromonas-gingivalis
#10
L Azzi, S Rania, R Vinci, F Spadari, F Croveri, C Scognamiglio, D Farronato, L Tettamanti, A Tagliabue, J Silvestre-Rangil, C Bellintani
Rheumatoid Arthritis is a disease, which can be described as an autoimmune response after molecular mimicry caused by infective agents. The current study aims at evaluating the correlation between Rhematoid Arthritis (RA) and Periodontal Disease (PD), with special attention to the microbioma detected in the gums. Thirty-four patients with RD were recruited into the current study. Among rheumatic parameters, Rheumatoid Factor (RF), anti-citrullinated protein antibody (CCP), HLA-BDR1 and DAS28 were collected...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28593775/-the-importance-of-maternal-microbiome-in-pregnancy
#11
J Záhumenský, J Hederlingová, P Pšenková
OBJECTIVE: To bring the most actual published findings of the influence of maternal microbiome on the development of pregnancy and possibilities of its adjusting. DESIGN: Review. SETTING: 2nd Department of Gyneacology and Obstetrics of the Faculty of Medicine and the University Hospital, Bratislava. METHODS: Review of the literature. CONCLUSIONS: The appearance of microbes on various body surface areas determines the overall health status of the individual in significant manner...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28544857/new-treatment-directions-for-ipf-current-status-of-ongoing-and-upcoming-clinical-trials
#12
Francesco Macagno, Francesco Varone, Paolo Maria Leone, Pier-Valerio Mari, Loredana Panico, Ludovica Berardini, Luca Richeldi
The main objective of this review is to explore the wide and expanding field of new clinical trials in IPF. Recent trials have confirmed the efficacy of the approved drugs pirfenidone and nintedanib; nonetheless, the discovery of new biological pathways has opened new horizons in this field. Areas covered: New strategies against matrix deposition are under study and so is for the role of immunity and autoimmunity. Recent advances in the use of stem cells are opening new possibilities for the recovery of damaged lung tissues...
July 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28472118/effect-of-dietary-supplementation-with-lactobacillus-acidophilus-d2-csl-cect-4529-on-caecum-microbioma-and-productive-performance-in-broiler-chickens
#13
Alessandra De Cesare, Federico Sirri, Gerardo Manfreda, Paola Moniaci, Alberto Giardini, Marco Zampiga, Adele Meluzzi
This study examines the effects of the dietary supplementation with Lactobacillus acidophilus D2/CSL (CECT 4529) (LA) on productive performances, incidence of foot pad dermatitis and caecum microbioma in broiler chickens. A total of 1,100 one-day old male Ross 308 chicks were divided into 2 groups of 16 replicates with 25 birds each and reared from 1-41 d. One group was fed a basal diet (CON) and the other group the same diet supplemented with LA. Caecum contents were collected from 4 selected birds at day one and 5 selected birds at the end of the rearing period...
2017: PloS One
https://www.readbyqxmd.com/read/28315049/antihypertensive-effects-of-probiotics
#14
REVIEW
Iñaki Robles-Vera, Marta Toral, Miguel Romero, Rosario Jiménez, Manuel Sánchez, Francisco Pérez-Vizcaíno, Juan Duarte
PURPOSE OF REVIEW: The present review focuses in the hypertension-associated changes in the microbiota and the current insights regarding the impact of probiotics on blood pressure in animal models and in human hypertensive patients. RECENT FINDINGS: Gut dysbiosis in hypertension is characterized by (i) the gut microbioma that is less diverse and less rich with an increased Firmicutes/Bacteroidetes ratio and (ii) a decrease in acetate- and butyrate-producing bacteria and an increase in lactate-producing bacterial populations...
April 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/27659100/cesarean-section-the-pediatricians-views
#15
Manuel R G Carrapato, Ana M Ferreira, Tuangsit Wataganara
Cesarean sections (CS) have greatly increased and many reasons are often evoked. Safer anesthetics and surgical procedures have rendered CS a popular choice for both professionals and mothers alike. CS on maternal request, for nonmedical reasons, is the subject of scientific, legal and ethical dispute. We shall address the CS issues, primarily, from the pediatrician's point of view. The immediate neonatal problems of the more mature neonate are well recognized. For preterm birth, contradictory results on mid- and long-term outcomes do not confirm the earlier reports on neonatal advantages of CS over vaginal delivery; therefore, their mode of delivery should be based on individual circumstances...
September 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26658649/urinary-tract-infections-in-women-with-urogynaecological-symptoms
#16
REVIEW
Marielle M E Lakeman, Jan-Paul W R Roovers
PURPOSE OF REVIEW: Urinary tract infections are common in the field of urogynaecology. Women with persistent urinary symptoms seem more likely to have bacteriuria despite negative cultures. In this review, we will give an overview of the recent insights on the relationship between urinary tract infection and persistent urinary symptoms and possible new therapeutic options. RECENT FINDINGS: Recently published articles evaluated the prevalence of low-count bacteriuria (≥10 CFU/ml) or intracellular bacterial communities in women with overactive bladder symptoms (OAB)...
February 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/26523202/epigenetic-mechanisms-in-non-alcoholic-fatty-liver-disease-an-emerging-field
#17
Rocío Gallego-Durán, Manuel Romero-Gómez
Non-alcoholic fatty liver disease (NAFLD) is an emerging health concern in both developed and non-developed world, encompassing from simple steatosis to non-alcoholic steatohepatitis (NASH), cirrhosis and liver cancer. Incidence and prevalence of this disease are increasing due to the socioeconomic transition and change to harmful diet. Currently, gold standard method in NAFLD diagnosis is liver biopsy, despite complications and lack of accuracy due to sampling error. Further, pathogenesis of NAFLD is not fully understood, but is well-known that obesity, diabetes and metabolic derangements played a major role in disease development and progression...
October 28, 2015: World Journal of Hepatology
https://www.readbyqxmd.com/read/26354428/occult-spondyloarthritis-in-inflammatory-bowel-disease
#18
REVIEW
Francesca Bandinelli, Mirko Manetti, Lidia Ibba-Manneschi
Spondyloarthritis (SpA) is a frequent extra-intestinal manifestation in patients with inflammatory bowel disease (IBD), although its real diffusion is commonly considered underestimated. Abnormalities in the microbioma and genetic predisposition have been implicated in the link between bowel and joint inflammation. Otherwise, up to date, pathogenetic mechanisms are still largely unknown and the exact influence of the bowel activity on rheumatic manifestations is not clearly explained. Due to evidence-based results of clinical studies, the interest on clinically asymptomatic SpA in IBD patients increased in the last few years...
February 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/25646885/clinical-trial-watch-reports-from-the-aasld-liver-meeting%C3%A2-boston-november-2014
#19
REVIEW
María-Carlota Londoño, Juan G Abraldes, José Altamirano, Thomas Decaens, Xavier Forns
The late and fast developments in the field of viral hepatitis were highly expected in the 2014 AASLD Liver Meeting®. Several combinations using direct acting antivirals (DAAs) showed high rates of sustained virological response (∼95%). Importantly, high cure rates were also demonstrated in patients with previous treatment failures, decompensated cirrhosis and hepatitis C recurrence after transplantation, making it clear that the interferon era is over (not so clear for ribavirin, which might still have a role in difficult-to-treat populations)...
May 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25218789/hepatic-encephalopathy-in-patients-with-acute-decompensation-of-cirrhosis-and-acute-on-chronic-liver-failure
#20
REVIEW
Manuel Romero-Gómez, Sara Montagnese, Rajiv Jalan
Hepatic encephalopathy in a hospitalized cirrhotic patient is associated with a high mortality rate and its presence adds further to the mortality of patients with acute-on-chronic liver failure (ACLF). The exact pathophysiological mechanisms of HE in this group of patients are unclear but hyperammonemia, systemic inflammation (including sepsis, bacterial translocation, and insulin resistance) and oxidative stress, modulated by glutaminase gene alteration, remain as key factors. Moreover, alcohol misuse, hyponatremia, renal insufficiency, and microbiota are actively explored...
February 2015: Journal of Hepatology
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