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Castlemans disease

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https://www.readbyqxmd.com/read/28929773/a-patient-with-castleman-s-disease-mimicking-acute-pancreatitis
#1
Jie Wu, Liang Lv, Chunlian Wang
Castleman's disease is a rare event that gastroenterologists should be familiar with. We present a case of Castleman's disease presenting as acute pancreatitis. The diagnosis was established by excisional biopsy of a superficial lymph node and the patient had a favorable prognosis with chemotherapy. This case is reminiscent of acute pancreatitis with multiple lymphadenopathy and should raise suspicion for Castleman's disease.
September 18, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28916317/presence-of-human-herpesvirus-8-hhv-8-dna-sequences-in-patients-with-lymphoproliferative-diseases-and-chronic-blood-disorders
#2
Hossein Keyvani, Mohammad Hadi Karbalaie Niya, Maryam Esghaei, Farah Bokharaei Salim, Seyed Hamid Reza Monavari
OBJECTIVE: Human herpesvirus 8 (HHV-8) is the causative agent of Kaposi's sarcoma (KS), but it has also been associated with different hematologic malignancies, including plasmablastic lymphoma, Multicentric Castleman's disease (MCD), primary effusion lymphoma (PEL) and various atypical lymphoproliferative disorders. Patients with underlying lymphoproliferative diseases and chronic blood disorders who become infected with this virus are at risk for human malignancies. This small study reported the frequency of human herpesvirus -8 in 81 Iranian patients with lymphoproliferative disorders for estimation of possible factors affecting malignancy...
September 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28914746/thin-section-computed-tomographic-findings-of-multicentric-castleman-disease-changing-over-10-years
#3
Hiroki Tashiro, Ryoko Egashira, Koichiro Takahashi, Shuichi Fukui, Takahiko Nakazono, Junichi Nojiri, Junya Fukuoka, Hiroyuki Irie, Shinya Kimura, Naoko Sueoka-Aragane
No abstract text is available yet for this article.
September 13, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28913319/rare-location-of-castleman-s-disease-in-the-temporal-region-a-case-report-involving-a-young-korean-woman-and-review-of-the-literature
#4
Wan Cheol Ryu, Moon Hyang Park, Hoon Kim, In Chang Koh, Kyu Nam Kim
Castleman's disease (CD) is an uncommon benign lymphoproliferative disorder of unknown etiology. Histopathologically, it is divided into three types: hyaline-vascular, plasma cellular, and multicentric CD. The mass usually presents asymptomatically; however, it can cause non-specific symptoms such as fever and fatigue. Although CD can be found wherever lymph nodes are present, 75% of cases are reported in the mediastinum, and occurrence in the head and neck is rare. Herein, we report a rare case of CD presenting as a superficial mass in the temporal region...
June 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28910876/-clinicopathologic-study-of-follicular-lymphoma-with-features-of-castleman-s-disease
#5
Z Wang, C Liu, Z H Zhang
No abstract text is available yet for this article.
September 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28906499/-incomplete-poems-syndrome-with-multicentric-castleman-s-disease
#6
P González de la Aleja, M García-Navarro, R Sánchez-Rodríguez, J M Ramos-Rincón
Castleman's disease (CD) is an atypical lymphoproliferative disorder of unknown cause, characterized by non-clonal nodal hyperplastic growth. Two forms of clinical presentation are currently recognized, one localized and the other multicentric, and four histopathologic variants. It is characterized by generalized lymphadenopathy, hepatosplenomegaly, fever and night sweats. CD may present severe pancytopenia, multi-organ failure, lymphoma evolution and it can sometimes be associated with paraneoplastic syndromes such as POEMS syndrome...
September 14, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28893942/kaposi-sarcoma-herpesvirus-pathogenesis
#7
REVIEW
Giuseppe Mariggiò, Sandra Koch, Thomas F Schulz
Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a phylogenetically old human virus that co-evolved with human populations, but is now only common (seroprevalence greater than 10%) in sub-Saharan Africa, around the Mediterranean Sea, parts of South America and in a few ethnic communities. KSHV causes three human malignancies, Kaposi sarcoma, primary effusion lymphoma, and many cases of the plasmablastic form of multicentric Castleman's disease (MCD) as well as occasional cases of plasmablastic lymphoma arising from MCD; it has also been linked to rare cases of bone marrow failure and hepatitis...
October 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28880697/tentative-diagnostic-criteria-and-disease-severity-classification-for-castleman-disease-a-report-of-the-research-group-on-castleman-disease-in-japan
#8
Shino Fujimoto, Tomohiro Koga, Atsushi Kawakami, Hiroshi Kawabata, Shinichiro Okamoto, Masao Mizuki, Shingo Yano, Makoto Ide, Kazuko Uno, Katsumi Yagi, Toshiyuki Kojima, Minoru Mizutani, Yukihiro Tokumine, Norihiro Nishimoto, Hiroshi Fujiwara, Shin-Ichi Nakatsuka, Kazuko Shiozawa, Noriko Iwaki, Yasufumi Masaki, Kazuyuki Yoshizaki
OBJECTIVES: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in the Japanese population. METHODS: We established the working groups for the research of CD in Japan and had meetings to discuss and define the tentative diagnostic criteria and disease severity classification for CD...
September 7, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28878084/human-herpesvirus-8-interleukin-6-interacts-with-calnexin-cycle-components-and-promotes-protein-folding
#9
Daming Chen, Qiwang Xiang, John Nicholas
Viral interleukin-6 (vIL-6) encoded by human herpesvirus 8 (HHV-8) is believed to contribute via mitogenic, survival, and angiogenic activities to HHV-8-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease through autocrine or paracrine mechanisms during latency or productive replication. There is direct evidence that vIL-6 promotes latently infected PEL cell viability and proliferation and also viral productive replication in PEL and endothelial cells. These activities are mediated largely through endoplasmic reticulum (ER)-localized vIL-6, which can induce signal transduction via the gp130 signaling receptor, activating mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) signaling, and interactions of vIL-6 with the ER membrane protein vitamin K epoxide reductase complex subunit 1 variant 2 (VKORC1v2)...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28877826/clinical-analysis-of-unicentric-castleman-s-disease-with-paraneoplastic-pemphigus-and-bronchiolitis-obliterans
#10
Jun-Feng Zhen, Lu Zhang, Xin-Xin Cao, Jun Feng, Dao-Bin Zhou, Song-Bai Lin, Jian Li
Objective To investigate the clinical features of unicentric Castleman's disease(UCD)with paraneoplastic pemphigus(PNP)and bronchiolitis obliterans(BO).Method Data of UCD patients with PNP and BO from Peking Union Medical College Hospital were retrospectively analyzed,along with literatures review. Results Totally 23 cases(11 males and 12 females)were enrolled.The median age was 31 years(13-56 years).The most common pathological type was hyaline-vascular variant(91.4%),and most tumors located in abdominopelvic cavity(69...
August 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28873356/follicular-lymphoma-with-hyaline-vascular-castleman-like-features-analysis-of-6-cases-and-review-of-the-literature
#11
Sergio Pina-Oviedo, Roberto N Miranda, Pei Lin, John T Manning, L Jeffrey Medeiros
Follicular lymphoma (FL) with features reminiscent of hyaline-vascular Castleman disease (CD) is an unusual morphologic variant that may create diagnostic difficulties. To our knowledge, only 5 cases of this variant have been reported. We describe the clinicopathologic features of 6 cases including 2 men and 4 women with a median age of 63years (range, 41-77). Morphologically, all lymph node biopsy specimens showed at least a focal area of conventional FL; 4 cases showed neoplastic follicles with hyalinized blood vessels penetrating into germinal centers (lollipop-like lesions); 4 cases had interfollicular areas with increased vascular stroma, 2 cases showed small neoplastic follicles with prominent, onion skin-like mantle zones, and 1 case showed two or more germinal centers within follicles (twinning)...
September 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/28863066/inflammatory-pseudotumor-presenting-as-a-mesosalpingeal-mass
#12
Simona Stolnicu, Robert A Soslow
We describe a case in which the clinical and pathologic features of a mesosalpingeal mass led to a diagnosis of inflammatory pseudotumor, an unusual tumor found in a rare location. The differential diagnosis is rather broad and includes lesions ranging from Castleman disease to an immunoglobulin G4-related fibrosclerosing tumor. The patient is alive and well at last follow-up.
August 31, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28845155/corrigendum-clinical-manifestations-of-kaposi-sarcoma-herpesvirus-lytic-activation-multicentric-castleman-disease-kshv-mcd-and-the-kshv-inflammatory-cytokine-syndrome
#13
Mark N Polizzotto, Thomas S Uldrick, Duosha Hu, Robert Yarchoan
[This corrects the article on p. 73 in vol. 3, PMID: 22403576.].
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28836561/castleman-s-disease-a-rare-mass-in-the-pararenal-retroperitoneum-that-mimics-other-tumors
#14
Yi Xie, Yi Zhao, Zhi-Gang Ji, Han-Zhong Li, Guang-Hua Liu, Quan-Zhong Mao
No abstract text is available yet for this article.
September 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28828768/gross-hepatosplenomegaly-in-a-patient-with-human-herpes-virus-8-associated-multicentric-castleman-s-disease
#15
Mohammad Fawwad Khattak
No abstract text is available yet for this article.
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28814592/fever-and-generalised-lymphadenopathy-in-an-hiv-positive-patient-a-diagnostic-challenge
#16
Bernardo Neves, Pedro Raimundo, Pedro Farinha
Fever and generalised lymphadenopathy is a common presentation of a variety of diseases and a thorough investigation is often necessary for appropriate diagnosis.We present a 53-year-old male patient admitted with fever, weight loss of 15 kg in 3 months and abdominal discomfort. Examination was only remarkable for axillary and inguinal lymphadenopathy. Blood tests showed normocytic normochromic anaemia, cholestasis and a previously unknown HIV-1 infection with lymphocyte CD4 +count of 239 cells/mm(3) and viral load 3...
August 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28794637/the-role-of-mediastinoscopy-in-the-diagnosis-of-non-lung-cancer-diseases
#17
Serdar Onat, Gungor Ates, Alper Avcı, Tekin Yıldız, Ali Birak, Cihan Akgul Ozmen, Refik Ulku
BACKGROUND: Mediastinoscopy is a good method to evaluate mediastinal lesions. We sought to determine the current role of mediastinoscopy in the investigation of non-lung cancer patients with mediastinal lymphadenopathy. MATERIALS AND METHODS: We retrospectively reviewed clinical parameters (age, gender, histological diagnosis, morbidity, mortality) of all patients without lung cancer who consecutively underwent mediastinoscopy in Hospital of Faculty of Medicine of Dicle University between June 2003 and December 2016...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28778870/interleukin-il-6-immunotherapy
#18
Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto
Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and contributes to host defense against such emergent stress through activation of acute-phase and immune responses. However, dysregulated excessive and persistent synthesis of IL-6 has a pathological effect on, respectively, acute systemic inflammatory response syndrome and chronic immune-mediated diseases. The IL-6 inhibitor, tocilizumab, a humanized anti-IL-6 receptor antibody, is currently being used for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, and Castleman disease...
August 4, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28777778/kshv-and-the-role-of-notch-receptor-dysregulation-in-disease-progression
#19
REVIEW
Jennifer L DeCotiis, David M Lukac
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of two human cancers, Kaposi's Sarcoma (KS) and primary effusion lymphoma (PEL), and a lymphoproliferation, Multicentric Castleman's Disease (MCD). Progression to tumor development in KS is dependent upon the reactivation of the virus from its latent state. We, and others, have shown that the Replication and transcriptional activator (Rta) protein is the only viral gene product that is necessary and sufficient for viral reactivation. To induce the reactivation and transcription of viral genes, Rta forms a complex with the cellular DNA binding component of the canonical Notch signaling pathway, recombination signal binding protein for Jk (RBP-Jk)...
August 4, 2017: Pathogens
https://www.readbyqxmd.com/read/28758262/paraneoplastic-pemphigus-seen-in-4-patients-with-hematologic-malignancies-formerly-treated-with-rituximab
#20
C Baykal, S Kılıç, R Küçükoğlu
Paraneoplastic pemphigus (PNP) is a peculiar variant of pemphigus with pathognomonic clinical, histological, and immunological features. It is typically associated with hematologic malignancies (84%), such as non-Hodgkin lymphomas (NHL) (most common), chronic lymphocytic leukemia (CLL), Castleman disease, thymoma, Waldenström's macroglobulinemia, Hodgkin lymphoma, and monoclonal gammopathy, as well as non-hematological neoplasms, such as epithelial carcinomas, mesenchymal sarcomas, and malignant melanoma. This article is protected by copyright...
July 31, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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