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https://www.readbyqxmd.com/read/28322454/long-term-local-control-rates-of-patients-with-adenoid-cystic-carcinoma-of-the-head-and-neck-managed-by-surgery-and-postoperative-radiation
#1
Safina Ali, Frank L Palmer, Nora Katabi, Nancy Lee, Jatin P Shah, Snehal G Patel, Ian Ganly
OBJECTIVES: To report long-term local control in patients with adenoid cystic cancer (ACC) of the head and neck managed by surgery and identify factors predictive for local failure. STUDY DESIGN: Single-institution retrospective cohort study. METHODS: Eighty-seven patients who had surgery for ACC between 1985 and 2009 were identified. Patient, tumor, and treatment characteristics were recorded. Local recurrence-free survival (LRFS) was recorded by the Kaplan-Meier method...
March 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28286830/mushroom-poisoning-in-the-northeast-of-iran-a-retrospective-6-year-epidemiologic-study
#2
Bita Dadpour, Shahrad Tajoddini, Maliheh Rajabi, Reza Afshari
INTRODUCTION: Toxic mushrooms are distributed across the globe with over 5000 species. Among them, 100 species are responsible for most of the cases of mushroom poisoning. This study aimed to evaluate the epidemiologic pattern of mushroom poisoning among patients referred to the main toxicology center of Mashhad province located in North-east of Iran. METHOD: This cross-sectional study was conducted on patients with final diagnosis of mushroom poisoning referred to the toxicology center of Mashhad, Iran, from February 2005 to 2011...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28228222/-surgical-treatment-and-prognosis-for-patients-with-%C3%A2-synchronous-multiple-primary-lung-adenocarcinomas
#3
Yue Peng, Hui Wang, Hounai Xie, Wangang Ren, Zhen Feng, Meng Li, Zhongmin Peng
BACKGROUND: With the popularization of high-resolution computed tomography (HRCT), there is a rising trend of the detection of multiple primary lung cancers (MPLC). Adenocarcinomas is the major pathological type of MPLC. At present, reports on MPLC are relatively common, but few study focused on synchronous multiple primary lung adenocarcinomas (SMPLA). We carried out this study in an attempt to enhance our understanding about SMPLA. METHODS: Data from 38 patients undergoing surgery for SMPLA in our institution frrom December 2012 and July 2016 were retrospectively collected...
February 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28223108/tenascin-c-is-a-prognostic-determinant-and-potential-cancer-associated-fibroblasts-marker-for-breast-ductal-carcinoma
#4
Zhaoting Yang, Weidong Ni, Chunai Cui, Longyun Fang, Yanhua Xuan
Tenascin C (TNC) is a key of extracellular matrix glycoprotein and highly express in numerous human malignancies. Herein, we attempted to clarify the clinicopathological significance of TNC as a prognostic determinant of breast ductal carcinoma. Then, we investigated TNC immunohistochemical expression in 150 breast ductal carcinomas and 27 normal breast tissue samples. Clinical relevance of TNC expression and the association TNC expression with other factors related to cancer-associated fibroblasts were also examined...
February 20, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28181096/high-expression-of-cell-division-cycle-42-promotes-pancreatic-cancer-growth-and-predicts-poor-outcome-of-pancreatic-cancer-patients
#5
Dejun Yang, Yu Zhang, Yajun Cheng, Liang Hong, Changming Wang, Ziran Wei, Qingping Cai, Ronglin Yan
BACKGROUND: Cell division cycle 42 (CDC42), an important member of the Rho family, is overexpressed in various human cancers. However, its expression and role in pancreatic cancer (PC) are not well understood. AIM: The present study was designed to investigate the expression patterns and underlying cellular mechanisms of CDC42 in PC. METHODS: First, immunohistochemical analysis, quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were performed to detect CDC42 expression in clinical pancreatic carcinoma and adjacent tissues...
February 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28116987/completeness-of-pathology-reports-in-stage-ii-colorectal-cancer
#6
Stefan Büttner, Zarina S Lalmahomed, Robert R J Coebergh van den Braak, Bettina E Hansen, Peter Paul L O Coene, Jan Willem T Dekker, David D E Zimmerman, Geert W M Tetteroo, Wouter J Vles, Wietske W Vrijland, Ruth E M Fleischeuer, Anneke A M van der Wurff, Mike Kliffen, Rolf Torenbeek, J H Carel Meijers, Michael Doukas, Jan N M IJzermans
INTRODUCTION: The completeness of the pathological examination of resected colon cancer specimens is important for further clinical management. We reviewed the pathological reports of 356 patients regarding the five factors (pT-stage, tumor differentiation grade, lymphovascular invasion, tumor perforation and lymph node metastasis status) that are used to identify high-risk stage II colon cancers, as well as their impact on overall survival (OS). METHODS: All patients with stage II colon cancer who were included in the first five years of the MATCH study (1 July 2007 to 1 July 2012) were selected (n = 356)...
January 24, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28031040/when-a-vehicle-becomes-a-weapon-intentional-vehicular-assaults-in-israel
#7
Gidon Almogy, Asaf Kedar, Miklosh Bala
BACKGROUND: We have recently witnessed an epidemic of intentional vehicular assaults (IVA) aimed at pedestrians. We hypothesized that IVA are associated with a specific injury pattern and severity. METHODS: Retrospective analysis of prospectively acquired data of patients injured following IVA from October 2008 to May 2016 who were admitted to the Hadassah Level I trauma center in Jerusalem, Israel. Comparison of injury parameters and outcome caused by vehicular attacks to non-intentional pedestrian trauma (PT)...
December 28, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28018106/elevated-fibrinogen-plasma-level-is-not-an-independent-predictor-of-poor-prognosis-in-a-large-cohort-of-western-patients-undergoing-surgery-for-colorectal-cancer
#8
Corrado Pedrazzani, Guido Mantovani, Gian Luca Salvagno, Elisabeth Baldiotti, Andrea Ruzzenente, Calogero Iacono, Giuseppe Lippi, Alfredo Guglielmi
AIM: To evaluate the clinical significance of the preoperative fibrinogen plasma level as a prognostic marker after surgery for colorectal cancer. METHODS: This retrospective study analysed 652 patients undergoing surgery for stage I-IV colorectal cancer between January 2005 and December 2012, at the Division of General Surgery A, University of Verona Hospital Trust, in whom preoperative fibrinogen plasma values were assessed at baseline. Fibrinogen is involved in tumourigenesis as well as tumour progression in several malignancies...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28012411/omitting-radiation-therapy-in-women-with-triple-negative-breast-cancer-leads-to-worse-breast-cancer-specific-survival
#9
I Kindts, P Buelens, A Laenen, E Van Limbergen, H Janssen, H Wildiers, C Weltens
PURPOSE: To examine locoregional recurrence (LRR) and breast cancer-specific survival (BCSS) after breast-conserving therapy (BCT) or mastectomy (ME) with or without radiation therapy (RT) in triple-negative breast cancer (TNBC). MATERIAL & METHODS: We identified non-metastatic TNBC cases from a single institution database. BCT, ME with RT (ME + RT) and ME only were compared with respect to LRR and BCSS. Cox regression models were used to analyze the association between prognostic factors and outcome...
April 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27995141/impact-of-training-on-three-dimensional-versus-two-dimensional-laparoscopic-systems-on-acquisition-of-laparoscopic-skills-in-novices-a-prospective-comparative-pilot-study
#10
Yasser A Noureldin, Ana Stoica, Pepa Kaneva, Sero Andonian
In this prospective educational study, 10 medical students (novices) were randomized to practice two basic laparoscopic tasks from the MISTELS program, namely, Pegboard Transfer (PT) and Intracorporeal Knot Tying (IKT) tasks, using either a 2D or a 3D laparoscopic platform. There was no significant difference between both groups in the baseline assessments (PT task: 130.8 ± 18.7 versus 151.5 ± 33.4; p = 0.35) (IKT task: 123.9 ± 41.0 versus 122.9 ± 44.9; p = 0.986). Following two training sessions, there was a significant increase in the scores of PT task for the 2D (130...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27994654/downregulation-of-rnf128-predicts-progression-and-poor-prognosis-in-patients-with-urothelial-carcinoma-of-the-upper-tract-and-urinary-bladder
#11
Yi-Ying Lee, Chieh-Tien Wang, Steven Kuan-Hua Huang, Wen-Jeng Wu, Chun-Nung Huang, Ching-Chia Li, Ti-Chun Chan, Peir-In Liang, Chung-Hsi Hsing, Chien-Feng Li
Background: The TP53 tumor suppressor gene plays a crucial role in the carcinogenesis of many malignancies, including urothelial carcinoma (UC). Overexpression of p53 is associated with poor prognosis in UC. Recently, RING finger protein 128 (RNF128) was shown to be involved in p53-induced apoptosis, forming a negative feedback loop. However, the significance of RNF128 in patients with UC remains unknown. In this study, our aim was to evaluate the expression of RNF128 in UC and to assess its predictive and prognostic value in a well-established cohort...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27987016/factors-affecting-the-postoperative-morbidity-and-survival-of-patients-with-liver-cirrhosis-following-colorectal-cancer-surgery
#12
Jun Ho Lee, Chang Sik Yu, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Jin Cheon Kim
PURPOSE: Data are lacking on the appropriate risk stratification of patients undergoing surgery for colorectal cancer (CRC). This study aimed to evaluate the predictive factors for perioperative morbidity and oncological outcomes in CRC patients with liver cirrhosis (LC). METHODS: A retrospective analysis of prospectively collected data was conducted. A total of 161 LC patients who underwent surgery for CRC were identified between January 2001 and December 2010...
December 16, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27935076/electrophysiologically-identified-piriformis-syndrome-is-successfully-treated-with-incobotulinum-toxin-a-and-physical-therapy
#13
Loren M Fishman, Allen N Wilkins, Bernard Rosner
INTRODUCTION: Piriformis syndrome is entrapment of the sciatic nerve by the piriformis muscle. METHODS: 56-person randomized, double-blinded, controlled study involving physical therapy and incobotulinum toxin A or placebo. INCLUSION CRITERIA: 3 standard deviation delay of posterior tibial (PT) or fibular FN) H-reflexes in flexion, adduction and internal rotation (FAIR-test), and normal paraspinal EMG. OUTCOME MEASURES: adverse side-effects, visual analogue scale (VAS), H-reflex delay in FAIR-test...
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27928868/effectiveness-of-decongestive-lymphatic-therapy-in-patients-with-lymphedema-resulting-from-breast-cancer-treatment-regardless-of-previous-lymphedema-treatment
#14
Mehtap Bozkurt, Lynn J Palmer, Ying Guo
Decongestive lymphatic therapy (DLT) has gained wide acceptance as an effective treatment for patients with lymphedema resulting from breast cancer treatment. It is unclear whether DLT is effective for patients with lymphedema who have received lymphedema treatment previously. Our purpose was to compare the effectiveness of DLT in patients who had received lymphedema treatment previously with those who had never received treatment. We retrospectively reviewed the medical records of 98 patients who received outpatient lymphedema therapy for upper extremity lymphedema following surgery...
December 7, 2016: Breast Journal
https://www.readbyqxmd.com/read/27905894/seroprevalence-of-bordetella-pertussis-specific-immunoglobulin-g-antibody-levels-among-asymptomatic-individuals-aged-4-to-24%C3%A2-years-a-descriptive-cross-sectional-study-from-sri-lanka
#15
Shamithra Sigera, Jennifer Perera, Jeyanthakumar Rasarathinam, Dulani Samaranayake, Dileepa Ediriweera
BACKGROUND: In Sri Lanka pertussis continues to circulate in the community and cases among adolescents and adults have been reported despite 95% coverage of the four dose pertussis vaccination during early childhood. Waning of immunity following natural infection or immunization may contribute to the persistent circulation. An adolescent booster dose is not included in the national immunization schedule of Sri Lanka, although this is routine practice in many countries. Therefore information on immunity to pertussis in the adolescent group is needed prior to considering vaccination schedule changes...
December 1, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27881889/expression-of-caf-related-proteins-is-associated-with-histologic-grade-of-breast-phyllodes-tumor
#16
Hye Min Kim, Yu Kyung Lee, Ja Seung Koo
Purpose. The purpose of this study was to investigate the expression of cancer-associated fibroblast- (CAF-) related proteins and the implications in breast phyllodes tumor (PT). Methods. Tissue microarrays of 194 PT cases (151 benign PT, 27 borderline PT, and 16 malignant PT) were constructed. We performed immunohistochemical staining for CAF-related proteins (podoplanin, prolyl 4-hydroxylase, FAPα, S100A4, PDGFR α/β, and NG2) and analyzed the results according to clinicopathologic parameters. Results. Expression of PDGFRα and PDGFRβ in the stromal component increased with increasing histologic grade of PT (p = 0...
2016: Disease Markers
https://www.readbyqxmd.com/read/27867543/primary-adenosquamous-carcinoma-of-the-esophagus-an-analysis-of-39-cases
#17
Peng-Zhi Ni, Yu-Shang Yang, Wei-Peng Hu, Wen-Ping Wang, Yong Yuan, Long-Qi Chen
BACKGROUND: Adenosquamous carcinoma (ASC) of the esophagus is an uncommon type of malignant esophageal neoplasm containing both squamous cell carcinoma (SCC) and adenocacinoma (AC) components. The aim of this study was to explore the clinical characteristics and prognosis of esophageal ASC. METHODS: A retrospective review of esophageal ASC patients who underwent transthoracic esophagectomy with lymphadenectomy in our hospital from July 2007 to April 2014. RESULTS: A total of 39 (1...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27853645/promoter-methylation-of-the-immune-checkpoint-receptor-pd-1-pdcd1-is-an-independent-prognostic-biomarker-for-biochemical-recurrence-free-survival-in-prostate-cancer-patients-following-radical-prostatectomy
#18
Diane Goltz, Heidrun Gevensleben, Jörn Dietrich, Jörg Ellinger, Jennifer Landsberg, Glen Kristiansen, Dimo Dietrich
Biomarkers that facilitate the prediction of disease recurrence in prostate cancer (PCa) may enable physicians to personalize treatment for individual patients. In the current study, PD-1 (PDCD1) promoter methylation was assessed in a cohort of 498 PCa patients included in The Cancer Genome Atlas (TCGA) and a second cohort of 300 PCa cases treated at the University Hospital of Bonn. In the TCGA cohort, the PD-1 promoter was significantly hypermethylated in carcinomas versus normal prostatic epithelium (55.5% vs...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27825551/repeated-sprint-ability-but-not-neuromuscular-fatigue-is-dependent-on-short-versus-long-duration-recovery-time-between-sprints-in-healthy-males
#19
Michael R Monks, Chris T Compton, Joseph D Yetman, Kevin E Power, Duane C Button
OBJECTIVES: During maximal intensity leg cycling sprints, previous research has shown that central and peripheral fatigue development occurs with various (<30s) short-duration recovery periods between sprints. The aim of the current study was to compare the development of neuromuscular fatigue during maximal intensity lower-body sprints interspersed with short and longer duration recovery periods. DESIGN: Crossover study. METHODS: Ten participants completed 10, 10s sprints interspersed with either 30 or 180s of recovery...
October 27, 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27793038/ddr2-overexpression-in-urothelial-carcinoma-indicates-an-unfavorable-prognosis-a-large-cohort-study
#20
Meng-Chen Tsai, Wei-Ming Li, Chun-Nung Huang, Hung-Lung Ke, Ching-Chia Li, Hsin-Chih Yeh, Ti-Chun Chan, Peir-In Liang, Bi-Wen Yeh, Wen-Jeng Wu, Sher-Wei Lim, Chien-Feng Li
The migration ability of urothelial carcinoma corresponding to dismal prognosis had not been fully investigated. The interaction of extracellular collagen with a unique transmembrane receptor tyrosine kinase, Discoidin domain receptor 2 (DDR2), was selected by data mining. We arranged real-time reverse transcription polymerase chain reaction assays to evaluate the transcript levels in 26 urinary tract urothelial carcinoma and 26 urinary bladder urothelial carcinoma specimens, showing significantly increase corresponding to advanced primary stage (p = 0...
October 25, 2016: Oncotarget
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