keyword
MENU ▼
Read by QxMD icon Read
search

PT 003

keyword
https://www.readbyqxmd.com/read/28889983/analysing-the-change-of-sagittal-balance-in-patients-with-lenke-5-idiopathic-scoliosis
#1
Okan Ozkunt, Gökhan Karademir, Kerim Sariyilmaz, Halil Can Gemalmaz, Fatih Dikici, Unsal Domanic
OBJECTIVE: The aim of this study was to evaluate preoperative and postoperative spinopelvic parameters and the influence of lowest instrumented vertebrae on sagittal parameters in Lenke 5 Adolescent Idiopathic Scoliosis (AIS) patients. METHODS: A total of 42 patients (37 females, 5 males; mean age: 16.71 ± 3.46 years) were included in the study. Preoperative and postoperative last follow up lumbar lordosis (LL), thoracic kyphosis (TK), pelvic tilt (PT), pelvic incidence (PI) and sacral slope (SS) angles measured...
September 7, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28880458/determinants-of-platelet-count-in-pediatric-patients-with-congenital-cyanotic-heart-disease-role-of-immature-platelet-fraction
#2
Randa M Matter, Iman A Ragab, Alaa M Roushdy, Ahmed G Ahmed, Hanan H Aly, Eman A Ismail
OBJECTIVES: Congenital heart defects are common noninfectious causes of mortality in children. Bleeding and thrombosis are both limiting factors in the management of such patients. We assessed the frequency of thrombocytopenia in pediatric patients with congenital cyanotic heart disease (CCHD) and evaluated determinants of platelet count including immature platelet fraction (IPF) and their role in the pathogenesis of thrombocytopenia. METHODS: Forty-six children and adolescents with CCHD during pre-catheter visits were studied; median age was 20...
September 7, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28862264/sox2-silenced-squamous-cell-carcinoma-a-highly-malignant-form-of-esophageal-cancer-with-sox2-promoter-hypermethylation
#3
Ritsuko Maehara, Kohei Fujikura, Kengo Takeuchi, Masayuki Akita, Shiho Abe-Suzuki, Jana Karbanová, Denis Corbeil, Tomoo Itoh, Yoshihiro Kakeji, Yoh Zen
This study originally aimed to investigate whether the overexpression of SOX2 is associated with the poor prognosis of patients with squamous cell carcinoma of the esophagus. However, we unexpectedly found that esophageal squamous cell carcinomas completely lacking SOX2 expression showed distinct pathologic features and highly aggressive clinical courses. The study cohort consisted of 113 consecutive patients with esophageal squamous cell carcinoma who underwent surgical resection without neoadjuvant therapy...
September 1, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28804763/effects-of-chest-physical-therapy-in-patients-with-non-tuberculous-mycobacteria
#4
Ashwin Basavaraj, Leopoldo Segal, Jonathan Samuels, Jeremy Feintuch, Joshua Feintuch, Kevin Alter, Daniella Moffson, Adrienne Scott, Doreen Addrizzo-Harris, Mengling Liu, David Kamelhar
Antibiotic therapy against non-tuberculous mycobacteria (NTM) is prolonged and can be associated with toxicity. We sought to evaluate whether chest physical therapy (PT) was associated with clinical improvement in patients with NTM not receiving anti-mycobacterial pharmacotherapy. A retrospective review of 77 subjects that were followed from June 2006 to September 2014 was performed. Baseline time point was defined as the first positive sputum culture for NTM; symptoms, pulmonary function, and radiology reports were studied...
2017: International Journal of Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/28698535/is-post-treatment-standardized-uptake-value-a-prognostic-factor-in-unresectable-non-small-cell-lung-carcinoma
#5
Ufuk Yılmaz, Zehra Yasar, Esra Korkmaz, Burcu Yalcın, Hakan Koparal, Engin Ozbilek
Aim Concurrent chemoradiotherapy (CRT) is the standard of care for locally advanced, unresectable non-small cell lung carcinoma (NSCLC). The aim of this study was to assess the prognostic value of maximum standardized uptake values (SUVmax) in patients with unresectable stage III NSCLC treated with concurrent CRT. Method 18F-FDG PET-CT scans were obtained before and after treatment in patients with unresectable stage III NSCLC treated with concurrent CRT. To determine the prognostic value of SUVmax of the primary tumor (PT), univariate and multivariate Cox regression model were carried out...
August 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28668287/prognostic-value-of-pd-1-and-pd-l1-expression-in-patients-with-high-grade-upper-tract-urothelial-carcinoma
#6
Laura-Maria Krabbe, Barbara Heitplatz, Sina Preuss, Ryan C Hutchinson, Solomon L Woldu, Nirmish Singla, Martin Boegemann, Christopher G Wood, Jose A Karam, Alon Z Weizer, Jay D Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Leonid M Rapoport, Peter V Glybochko, Marco Roscigno, Christian Bolenz, Karim Bensalah, Arthur I Sagalowsky, Shahrokh F Shariat, Yair Lotan, Evanguelos Xylinas, Vitaly Margulis
PURPOSE: We investigated the prognostic value of PD-1 and PD-L1 expression in patients with high grade upper tract urothelial carcinoma. MATERIALS AND METHODS: Tissue microarrays of 423 patients treated with extirpative surgery for high grade upper tract urothelial carcinoma from the International Upper Tract Urothelial Carcinoma collaboration were stained for PD-1 and PD-L1 using antibodies, including Cell Marque™ NAT105 diluted 1:250 and prediluted E1L3N® via immunohistochemistry...
June 28, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28627000/pencil-beam-scanned-protons-for-the-treatment-of-patients-with-ewing-sarcoma
#7
Damien C Weber, Fritz R Murray, Dora Correia, Alessandra Bolsi, Martina Frei-Welte, Alessia Pica, Antony J Lomax, Ralf Schneider, Barbara Bachtiary
BACKGROUND: Few data exist regarding the clinical outcome of patients with Ewing sarcoma (EWS) treated with pencil beam scanning proton therapy (PT). We report the outcome of children, adolescents and young adults (AYA) treated with PT at the Paul Scherrer Institute. MATERIALS: Thirty-eight patients (median age, 9.9 years) received a median dose of 54.9 Gy(RBE) (where RBE is relative biologic effectiveness). Size of the tumor ranged from 1.7 to 24 cm. Most common primary site was axial/pelvic (n = 27; 71%)...
June 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28587816/prognostic-value-of-the-preoperative-platelet-to-leukocyte-ratio-for-oncologic-outcomes-in-patients-undergoing-radical-cystectomy-for-bladder-cancer
#8
Gerald B Schulz, Tobias Grimm, Alexander Buchner, Friedrich Jokisch, Markus Grabbert, Birte-Swantje Schneevoigt, Alexander Kretschmer, Christian G Stief, Alexander Karl
BACKGROUND: Currently, stratification of patients with bladder cancer (BC) mainly relies on histopathologic and clinical staging. Furthermore, inflammation plays an important role in the pathogenesis of BC. With the preoperative platelet-to-leukocyte ratio (PLR), we introduce a novel prognostic marker based on routine hematologic values in patients undergoing radical cystectomy (RC). PATIENTS AND METHODS: In our cohort of 665 patients undergoing RC (2004-2015) for urothelial carcinoma of the bladder (UCB), we analyzed a variety of preoperative hematologic parameters...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28578871/subclassification-of-pn3-staging-systems-for-penile-cancer-proposal-for-modification-of-the-current-tnm-classification
#9
Zhiyong Li, Shengjie Guo, Zhiming Wu, Hui Han, Zaishang Li, Yanjun Wang, Dong Chen, Jieping Chen, Chuangzhong Deng, Zike Qin, Zhuowei Liu, Yonghong Li, Kai Yao, Fanjian Zhou
OBJECTIVE: To validate the clinical and prognostic significance of our proposed pN3 subclassification in penile cancer. MATERIALS AND METHODS: A retrospective analysis of 509 patients with penile cancer undergoing partial, total penectomy or inguinal lymphadenectomy or pelvic lymphadenectomy at Sun Yat-sen University Cancer Center was reevaluated by pathologists. pN3 stage was subclassified into pN3a (extranodal extension of any inguinal lymph node [LN] metastasis only) and pN3b (pelvic LN metastasis)...
June 1, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28557042/enhancing-the-catalytic-activity-of-zeolitic-imidazolate-framework-8-derived-n-doped-carbon-with-incorporated-ceo2-nanoparticles-in-the-oxygen-reduction-reaction
#10
Yue Yu, Li Gao, Xianchun Liu, Yuanhong Wang, Shuangxi Xing
Incorporation of CeO2 nanoparticles into the cavity of zeolitic imidazolate framework-8 (ZIF-8) was followed by high-temperature pyrolysis to generate CeO2 @N-doped carbon materials. Introduction of the CeO2 nanoparticles greatly enhanced the catalytic activity of the ZIF-8-derived carbon materials in the oxygen reduction reaction (ORR) owing to the presence of Ce(3+) and oxygen vacancies with high content of chemisorbed oxygen in CeO2 and the well-maintained skeleton of the original ZIF-8 with uniform mesoporous structure...
May 29, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28546759/predictive-significance-of-hmgcs2-for-prognosis-in-resected-chinese-esophageal-squamous-cell-carcinoma-patients
#11
Hong Tang, Yufeng Wu, Yanru Qin, Hongyan Wang, Yongxu Jia, Shujun Yang, Suxia Luo, Qiming Wang
Despite a series of attempts during the last decades, the prognosis of esophageal squamous cell carcinoma (ESCC) remains poor. Different responses of individual tumors encouraged us to look for valuable prognostic markers. As a key regulator controlling the anabolic ketogenic pathway, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) has been reported to play a crucial role in colorectal cancer and prostate cancer. However, its importance to ESCC has not been verified. Therefore, a large cohort retrospective study was planned, to investigate the relationship between HMGCS2 expression and ESCC prognosis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28545841/oncologic-outcomes-for-patients-with-residual-cancer-at-cystectomy-following-neoadjuvant-chemotherapy-a-pathologic-stage-matched-analysis
#12
Bimal Bhindi, Igor Frank, Ross J Mason, Robert F Tarrell, Prabin Thapa, John C Cheville, Brian A Costello, Lance C Pagliaro, R Jeffrey Karnes, R Houston Thompson, Matthew K Tollefson, Stephen A Boorjian
While it has been demonstrated that receipt of neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) improves survival compared to RC alone, the driving factor for this benefit may be from patients with ypT0 status at surgery. Meanwhile, the implications of having residual urothelial carcinoma of the bladder (rUCB) at RC after NAC are less clear. We therefore evaluated whether survival differed between patients with rUCB at RC after NAC and stage-matched controls who underwent RC alone. Patients who underwent NAC + RC (n = 180) were matched to controls who underwent RC alone (n=324) on the basis of pT and pN stage, margin status, and year of RC...
May 22, 2017: European Urology
https://www.readbyqxmd.com/read/28529615/a-novel-blood-tool-of-cancer-prognosis-in-esophageal-squamous-cell-carcinoma-the-fibrinogen-albumin-ratio
#13
Zihui Tan, Man Zhang, Qiang Han, Jing Wen, Kongjia Luo, Peng Lin, Lanjun Zhang, Hong Yang, Jianhua Fu
Background: Coagulation and nutrition play important roles in cancer progression. We aim to investigate the impact of the fibrinogen/albumin ratio(FAR) in esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed 1135 patients with radical esophagectomy for ESCC from January 2008 to December 2010 in our center. X-tile software was used to determine the optimal cutoff levels for these biomarkers. Results: The optimal cutoff value was 0.08 for the FAR by the X-tile software. The FAR was statistically significantly associated with age(p=0...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28527002/design-and-development-of-amperometric-biosensor-for-the-detection-of-lead-and-mercury-ions-in-water-matrix-a-permeability-approach
#14
Manju Bhargavi Gumpu, Uma Maheswari Krishnan, John Bosco Balaguru Rayappan
Intake of water contaminated with lead (Pb(2+)) and mercury (Hg(2+)) ions leads to various toxic effects and health issues. In this context, an amperometric urease inhibition-based biosensor was developed to detect Pb(2+) and Hg(2+) ions in water matrix. The modified Pt/CeO2/urease electrode was fabricated by immobilizing CeO2 nanoparticles and urease using a semi-permeable adsorption layer of nafion. With urea as a substrate, urease catalytic activity was examined through cyclic voltammetry. Further, maximum amperometric inhibitive response of the modified Pt/CeO2/urease electrode was observed in the presence of Pb(2+) and Hg(2+) ions due to the urease inhibition at specific potentials of -0...
May 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28489882/preparation-of-a-novel-antiserum-to-aromatase-with-high-affinity-and-specificity-its-clinicopathological-significance-on-breast-cancer-tissue
#15
Naoki Kanomata, Shiro Matsuura, Tsunehisa Nomura, Junichi Kurebayashi, Taisuke Mori, Jo Kitawaki, Takuya Moriya
Aromatase inhibitors have been widely used for the endocrine treatment of estrogen-dependent breast cancer in postmenopausal patients. However, clinicopathological studies of aromatase have been limited due to unsatisfactory specificity and/or restricted availability of anti-aromatase antibodies. Here, we have generated a polyclonal antiserum with high affinity and specificity for human aromatase using a monoclonal antibody tagged immunoaffinity chromatography on an industrial production scale. Our preliminary immunohistochemical analysis of 221 invasive breast cancer cases indicated that 87...
2017: PloS One
https://www.readbyqxmd.com/read/28468583/circulating-mir-1826-in-plasma-correlates-with-circulating-tumor-cells-and-is-a-prognostic-marker-in-colorectal-cancer
#16
Zhihua Xu, Tianyi Xi, Ye Han, Xiaobo Guo, Fei Liu, Min Jiang, Daiwei Wan, Xiaofeng Xue, Songbing He, Rui Ren, Wei Li, Qiaoming Zhi
Our previous study showed that miR-1826 was a newly identified oncogenic non-coding RNA in colorectal cancer. But the potential relationship between miR-1826 and tumor metastasis has not been fully elucidated. The purpose of this study was to evaluate the clinical significance of circulating miR-1826 and its possible associations with circulating tumor cells in colorectal cancer. Our results first found that serum miR-1826 was significantly upregulated in colorectal cancer patients, compared with that in healthy volunteers ( p = 0...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28465585/large-spin-hall-angle-in-vanadium-film
#17
T Wang, W Wang, Y Xie, M A Warsi, J Wu, Y Chen, V O Lorenz, X Fan, J Q Xiao
We report a large spin Hall angle observed in vanadium films sputter-grown at room temperature, which have small grain size and consist of a mixture of body centered tetragonal (bct) and body centered cubic (bcc) structures. The spin Hall angle is as large as θ V  = -0.071 ± 0.003, comparable to that of platinum, θ Pt  = 0.076 ± 0.007, and is much larger than that of bcc V film grown at 400 °C, θ V_bcc  = -0.012 ± 0.002. Similar to β-tantalum and β-tungsten, the sputter-grown V films also have a high resistivity of more than 200 μΩ∙cm...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28452632/the-impact-of-spinopelvic-morphology-on-the-short-term-outcome-of-pedicle-subtraction-osteotomy-in-104-patients
#18
Karin Eskilsson, Deep Sharma, Christer Johansson, Rune Hedlund
OBJECTIVE Pedicle subtraction osteotomy (PSO) is commonly performed for correction of spinal sagittal plane deformities. The PSO results in complex, multiple changes of the spinopelvic alignment. The influence of the variability of individual pelvic morphology has not been fully analyzed in previous outcome studies of sagittal imbalance. The aim of this study was to define radiological variables affecting the outcome after PSO in adult spinal deformities, with special emphasis on the variability of pelvic morphology...
July 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28428106/gata3-immunohistochemistry-in-urothelial-carcinoma-of-the-upper-urinary-tract-as-a-urothelial-marker-and-a-prognosticator
#19
Satoshi Inoue, Taichi Mizushima, Kazutoshi Fujita, Abdelrazak Meliti, Hiroki Ide, Seiji Yamaguchi, Hiroaki Fushimi, George J Netto, Norio Nonomura, Hiroshi Miyamoto
Immunohistochemistry of a transcription factor, GATA3, has been widely used as a promising urothelial marker in diagnostic surgical pathology practice. However, the expression status of GATA3 in upper urinary tract urothelial carcinomas (UUTUCs) and its prognostic significance have not been fully investigated. We immunohistochemically stained for GATA3 in 99 UUTUC samples and paired nonneoplastic urothelial tissues. GATA3 was positive in 51 (51.5%; 32 [32.3%] weak, 11 [11.1%] moderate, 8 [8.1%] strong) of 99 UUTUCs, which was significantly lower than in benign urothelium (79 [96...
June 2017: Human Pathology
https://www.readbyqxmd.com/read/28422310/adult-onset-cystic-fibrosis-liver-disease-diagnosis-and-characterization-of-an-underappreciated-entity
#20
Christopher Koh, Sasan Sakiani, Pallavi Surana, Xiongce Zhao, Jason Eccleston, David E Kleiner, David Herion, T Jake Liang, Jay H Hoofnagle, Milica Chernick, Theo Heller
Cystic fibrosis (CF) liver disease (CFLD), a leading cause of death in CF, is mostly described in pediatric populations. Adult-onset CFLD lacks sufficient characterization and diagnostic tools. A cohort of CF patients without CFLD during childhood were followed for up to 38 years with serologic testing, imaging, and noninvasive fibrosis markers. Historical CFLD diagnostic criteria were compared with newly proposed CFLD criteria. Thirty-six CF patients were followed for a median of 24.5 years (interquartile range 15...
August 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
keyword
keyword
87796
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"