Daniela Strenkert, Stefan Schmollinger, Srinand Paruthiyil, Bonnie C Brown, Sydnee Green, Catherine M Shafer, Patrice Salomé, Hosea Nelson, Crysten E Blaby-Haas, Jeffrey L Moseley, Sabeeha S Merchant
Successful acclimation to copper (Cu) deficiency involves a fine balance between Cu import and export. In the green alga Chlamydomonas reinhardtii, Cu import is dependent on a transcription factor, Copper Response Regulator 1 (CRR1), responsible for activating genes in Cu-deficient cells. Among CRR1 target genes are two Cu transporters belonging to the CTR/COPT gene family (CTR1 and CTR2) and a related soluble protein (CTR3). The ancestor of these green algal proteins was likely acquired from an ancient chytrid and contained conserved cysteine-rich domains (named the CTR-associated domains, CTRA) that are predicted to be involved in Cu acquisition...
March 4, 2024: Metallomics: Integrated Biometal Science