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cortical reorganization in cervical spondylotic myelopathy

Indira Devi Bhagavatula, Dhaval Shukla, Nishanth Sadashiva, Praveen Saligoudar, Chandrajit Prasad, Dhananjaya I Bhat
OBJECTIVE The physiological mechanisms underlying the recovery of motor function after cervical spondylotic myelopathy (CSM) surgery are poorly understood. Neuronal plasticity allows neurons to compensate for injury and disease and to adjust their activities in response to new situations or changes in their environment. Cortical reorganization as well as improvement in corticospinal conduction happens during motor recovery after stroke and spinal cord injury. In this study the authors aimed to understand the cortical changes that occur due to CSM and following CSM surgery and to correlate these changes with functional recovery by using blood oxygen level-dependent (BOLD) functional MRI (fMRI)...
June 2016: Neurosurgical Focus
Andrew Green, Priscilia W T Cheong, Stephanie Fook-Chong, Rajendra Tiruchelvarayan, Chang Ming Guo, Wai Mun Yue, John Chen, Yew Long Lo
BACKGROUND: Cervical spondylotic myelopathy (CSM) results in sensorimotor limb deficits, bladder, and bowel dysfunction, but mechanisms underlying motor plasticity changes before and after surgery are unclear. METHODS: We studied 24 patients who underwent decompression surgery and 15 healthy controls. Patients with mixed upper and lower limb dysfunction (Group A) and only lower limb dysfunction (Group B) were then analysed separately. RESULTS: The sum amplitude of motor evoked potentials sMEP (p < 0...
2015: Neural Plasticity
Fuqing Zhou, Lin Wu, Xiaojia Liu, Honghan Gong, Keith Dip-Kei Luk, Yong Hu
BACKGROUND AND PURPOSE: Recent advanced MRI studies on cervical spondylotic myelopathy (CSM) revealed alterations of sensorimotor cortex, but the disturbances of large-scale thalamocortical systems remains elusive. The purpose of this study was to characterizing the CSM-related thalamocortical disturbances, which were associated with spinal cord structural injury, and clinical measures. METHODS: A total of 17 patients with degenerative CSM and well-matched control subjects participated...
2015: PloS One
Samantha Tam, Robert L Barry, Robert Bartha, Neil Duggal
BACKGROUND AND IMPORTANCE: Spinal cord compression may induce cortical reorganization. This study follows a patient with cervical spondylotic myelopathy to investigate changes in cortical activation before and after decompressive surgery. The relationship with functional recovery is also described. CLINICAL PRESENTATION: A 37-year-old right-hand-dominant man presented a 1-month history of rapidly worsening right-hand clumsiness, right-sided hemiparesis, and gait difficulties...
September 2010: Neurosurgery
Langston T Holly, Yun Dong, Richard Albistegui-DuBois, Jonathan Marehbian, Bruce Dobkin
OBJECT: Recent investigations have demonstrated that the cerebral cortex can reorganize as a result of spinal cord injury and may play a role in preserving neurological function. Reorganization of cortical representational maps in patients with cervical spondylotic myelopathy (CSM) has not been previously described. The authors sought to determine the feasibility of using functional magnetic resonance (fMR) imaging in patients with CSM to investigate changes in the cortical representation of the wrist and ankle before and after surgical intervention...
June 2007: Journal of Neurosurgery. Spine
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