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https://www.readbyqxmd.com/read/29450615/contrast-enhanced-ultrasound-ceus-in-abdominal-intervention
#1
REVIEW
Dean Y Huang, Gibran T Yusuf, Mohammad Daneshi, Raymond Ramnarine, Annamaria Deganello, Maria E Sellars, Paul S Sidhu
The introduction of ultrasound contrast agents has rendered contrast-enhanced ultrasound (CEUS) a valuable complementary technique to address clinically significant problems. This pictorial review describes the use of CEUS guidance in abdominal intervention and illustrates such application for a range of clinical indications. Clinical application of CEUS discussed include commonly performed abdominal interventional procedures, such as biopsy, drainage, nephrostomy, biliary intervention, abdominal tumor ablation and its subsequent monitoring, and imaging of vascular complications following abdominal intervention...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29444709/mucinous-cystic-neoplasm-of-the-liver-with-extrahepatic-growth-presenting-with-ascending-cholangitis-diagnosed-by-endoscopic-ultrasound-features-a-case-report
#2
Tanawat Pattarapuntakul, Bancha Ovartlarnporn, Jaksin Sottisuporn
BACKGROUND: Mucinous cystic neoplasm of the liver with extrahepatic growth is a rare benign epithelial neoplasm of the biliary system that presents with a mass effect or is incidentally found on imaging. The tumor affects mostly the common hepatic duct, which is difficult to diagnose preoperatively by radiology, endoscopy, or cystic fluid analysis. Endoscopic ultrasound is a noninvasive tool for the evaluation of features of a cystic lesion and the extent of disease. Optimal treatment is complete tumor resection...
February 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29438681/the-diagnostic-value-of-five-serum-tumor-markers-for-patients-with-cholangiocarcinoma
#3
Yuanfu Qiu, Jian He, Xinliang Chen, Pinbo Huang, Kaishun Hu, Haiyan Yan
OBJECTIVE: To assess the clinical significance and diagnostic value of the single and combined detection of five tumor markers in patients with cholangiocarcinoma. METHODS: In total, 296 patients with biliary tract disease who were diagnosed and received treatment at Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University during April 2011 to Dec 2017 were chosen for this study. Patients were divided into a cholangiocarcinoma group and a benign biliary tract disease group...
February 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29428971/emergence-of-anti-mitochondrial-m2-antibody-in-patient-with-angioimmunoblastic-t-cell-lymphoma
#4
Shun-Ichi Wakabayashi, Takefumi Kimura, Naoki Tanaka, Satoru Joshita, Kazuhito Kawata, Takeji Umemura, Yuki Hiroshima, Hiromitsu Mori, Hikaru Kobayashi, Shuichi Wada, Eiji Tanaka
A 68-year-old woman was referred to our hospital due to fever and rash on the neck and extremities. Laboratory findings revealed hepatic dysfunction and positivity for anti-mitochondrial M2 antibody (AMA-M2). Hepatosplenomegaly and systemic lymphadenopathy were detected by enhanced computed tomography. One week after her first visit, hypoxemia, ascites, and Coomb test-positive autoimmune hemolytic anemia had newly appeared in addition to worsened fever, hepatosplenomegaly, and lymphadenopathy. Results of axillary lymph node, skin, and bone-marrow biopsies led to the diagnosis of angioimmunoblastic T-cell lymphoma (AITL), for which CEPP therapy (cyclophosphamide, etoposide, procarbazine, and prednisolone) was initiated...
February 10, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29428100/clinical-analysis-of-liver-transplantation-in-autoimmune-liver-diseases
#5
Cheng-Peng Zhong, Zhi-Feng Xi, Qiang Xia
BACKGROUND: Autoimmune liver diseases (ALDs) consist of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), IgG4-associated cholangitis and overlap syndromes. Patients with these diseases may gradually progress to end-stage liver diseases and need liver transplantation. The present study aimed to explore the prognosis of patients with ALDs after liver transplantation. METHODS: The clinical data of 80 patients with ALD (24 cases of AIH, 35 of PBC, 15 of PSC and 6 of AIH-PBC overlap syndromes) who underwent liver transplantation in Renji Hospital, Shanghai Jiao Tong University School of Medicine from June 2004 to September 2016 were collected retrospectively...
February 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29416916/genotyping-and-mrna-profiling-reveal-actionable-molecular-targets-in-biliary-tract-cancers
#6
Kyriaki Papadopoulou, Samuel Murray, Kyriaki Manousou, Ioannis Tikas, Christos Dervenis, Joseph Sgouros, Dimitra Rontogianni, Sotirios Lakis, Mattheos Bobos, Christos Poulios, Stavroula Pervana, Georgios Lazaridis, George Fountzilas, Vassiliki Kotoula
Biliary tract cancer (BTC) represents a heterogeneous disease with dismal outcome. Herein, we examined genotype and angiogenesis features in BTC. We applied genotyping (Sanger, qPCR, 101-gene panel NGS), mRNA relative quantification methods, and β-catenin immunohistochemistry in 84 FFPE BTC (55 gallbladder [GBC], 14 intrahepatic [ICC], 15 extrahepatic [ECC] carcinomas). We identified 541 mutations in 68 (81%) tumors. Top mutated genes were CTNNB1 (36%); PTEN (33%); TP53 (31%); PIK3R1 (29%); PIK3CA (13%); BRCA2 and KRAS (12%); BRCA1 (11%)...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29413947/styk1-promotes-cancer-cell-proliferation-and-malignant-transformation-by-activating-pi3k-akt-pathway-in-gallbladder-carcinoma
#7
Yun-Ping Hu, Zeng-Bin Wu, Lin Jiang, Yun-Peng Jin, Huai-Feng Li, Yi-Jian Zhang, Qiang Ma, Yuan-Yuan Ye, Zheng Wang, Yong-Chen Liu, Hong-Zhuan Chen, Ying-Bin Liu
Gallbladder carcinoma (GBC) is the most common malignancy of the biliary tract with extremely poor prognosis. The malignant transformation of GBC is associated with cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). However, the molecular mechanisms underlying GBC progression are poorly understood. We found that serine threonine tyrosine kinase 1 (STYK1) was elevated in GBC and was negatively correlated with clinical outcomes and prognosis. Overexpression of STYK1 in GBC cell lines gave rise to increased cell proliferation, colony formation, migration and invasion, thus committing cells to undergoing EMT...
January 31, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29409305/prospective-comparison-of-intraductal-ultrasonography-guided-transpapillary-biopsy-and-conventional-biopsy-on-fluoroscopy-in-suspected-malignant-biliary-strictures
#8
Hyun Su Kim, Jong Ho Moon, Yun Nah Lee, Hyun Jong Choi, Hyun Woo Lee, Hee Kyung Kim, Tae Hoon Lee, Moon Han Choi, Sang-Woo Cha, Young Deok Cho, Sang-Heum Park
Background/Aims: In suspected malignant biliary strictures (MBSs), the diagnostic yield of endoscopic retrograde cholangiopancreatography (ERCP)-based tissue sampling is limited. Transpapillary forceps biopsy (TPB) under intraductal ultrasonography (IDUS) guidance is expected to improve the diagnostic accuracy in patients with indeterminate biliary strictures. We evaluated the usefulness of IDUS-guided TPB in patients with suspected MBS. Methods: Consecutive patients with suspected MBS were prospectively enrolled in the study...
February 8, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29404753/defining-early-recurrence-of-hilar-cholangiocarcinoma-after-curative-intent-surgery-a-multi-institutional-study-from-the-us-extrahepatic-biliary-malignancy-consortium
#9
Xu-Feng Zhang, Eliza W Beal, Jeffery Chakedis, Qinyu Chen, Yi Lv, Cecilia G Ethun, Ahmed Salem, Sharon M Weber, Thuy Tran, George Poultsides, Andre Y Son, Ioannis Hatzaras, Linda Jin, Ryan C Fields, Stefan Buettner, Charles Scoggins, Robert C G Martin, Chelsea A Isom, Kamron Idrees, Harveshp D Mogal, Perry Shen, Shishir K Maithel, Carl R Schmidt, Timothy M Pawlik
BACKGROUND: Time to tumor recurrence may be associated with outcomes following resection of hepatobiliary cancers. The objective of the current study was to investigate risk factors and prognosis among patients with early versus late recurrence of hilar cholangiocarcinoma (HCCA) after curative-intent resection. METHODS: A total of 225 patients who underwent curative-intent resection for HCCA were identified from 10 academic centers in the USA. Data on clinicopathologic characteristics, pre-, intra-, and postoperative details and overall survival (OS) were analyzed...
February 5, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29402439/drug-development-and-clinical-trial-design-in-pancreatico-biliary-malignancies
#10
REVIEW
Jennifer Harrington, Louise Carter, Bristi Basu, Natalie Cook
Pancreatico-biliary (P-B) tumors arise from the pancreas, bile duct, and ampulla of Vater. Despite their close anatomical location, they have different etiology and biology. However, they uniformly share a poor prognosis, with no major improvements observed in overall survival over decades, even in the face of progress in diagnostic imaging and surgical techniques, and advances in systemic and loco-regional radiation therapies. To date, cytotoxic treatment has been associated with modest benefits in the advanced disease setting, and survival for patients with stage IV disease has not exceeded a year...
January 8, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29394807/-a-case-of-successful-adjuvant-surgery-for-the-pancreas-head-cancer-with-peritoneal-metastasis
#11
Yukie Kyakumoto, Tatsuyuki Takadate, Masamichi Mizuma, Tatsuo Hata, Masahiro Iseki, Hideo Ohtsuka, Naoaki Sakata, Kei Nakagawa, Takanori Morikawa, Hiroki Hayashi, Fuyuhiko Motoi, Takeshi Naitoh, Atsushi Kanno, Tooru Shimosegawa, Michiaki Unno
We report a case of the pancreas head cancer with peritoneal metastasis, which was resected curatively after chemotherapy. A6 6-year-old male was referred to our hospital for the treatment of biliary stenosis. The serum CA19-9 level was elevated and abdominal CT scan showed stenosis of distal bile duct. By laparotomy, we noticed mass in the head of the pancreas with 8mm of the seeding nodule in a diameter at jejunal mesentery which was diagnosed as adenocarcinoma by intraoperative frozen sections. Therefore, the patient was diagnosed as pancreas head cancer with peritoneal metastasis...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394788/-a-case-report-of-an-elderly-patient-s-intrahepatic-cholangiocellular-carcinoma-with-cholangitis
#12
Hiroshi Ito, Toshiya Ochiai, Hiroki Nakatsuji, Hiroyuki Inoue, Nobuyuki Watanabe, Atsushi Yoshiyama, Atsushi Toma, Kenji Nakamura, Eigo Otsuji
We report a case of an elderly patient diagnosed with intrahepatic cholangiocellular carcinoma with cholangitis.An 88- year-old woman presented with fever.Computed tomography examination showed a hepatic tumor and dilation of the peripheral bile duct.Cholangiocarcinoma was diagnosed.Biliary tract drainage and palliative care were suggested because of her age.However, her family asked for a second opinion about operative management and consulted our hospital.Radical operations for intrahepatic cholangiocellular carcinoma that has spread to the left lobe are usually accompanied by widespread lymph node dissection and extensive hepatectomy with biliary tract reconstruction...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394618/-a-case-of-resected-metachronous-cholangiocarcinoma-after-pancreaticoduodenectomy
#13
Kazuhiko Hashimoto, Kei Adachi, Ryouji Nonaka, Jeong-Ho Moon, Yujiro Fujie, Shoichiro Fujita, Keiko Kojima, Jun Hanai, Shingi Imaoka, Tadashi Ohnishi
The patient was a 79-year-old woman, who had undergone pancreaticoduodenectomy(PD)for lower bile duct carcinoma in our hospital(pT3N0H0P0M0, fStage III ). Four years 6 months after the initial operation, abdominal CT revealed left bile duct expansion and hilar bile duct thickening. Therefore, based on the diagnosis of perihilar cholangiocarcinoma originating from the left hilar duct, we performed left lobectomy with caudate lobectomy and biliary tract reconstruction. The surgical specimen showed a tumor in the left hilar bile duct...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29393556/contrast-enhanced-ultrasound-complements-two-dimensional-ultrasonography-in-diagnosing-gallbladder-diseases-in-dogs
#14
Paolo Bargellini, Riccardo Orlandi, Chiara Paloni, Giuseppe Rubini, Paolo Fonti, Cecilia Righi, Mark E Peterson, Mark Rishniw, Cristiano Boiti
Gall-bladder diseases are common in dogs and two-dimensional ultrasonography is a current standard method for diagnosis and treatment planning. However, findings from this modality can be nonspecific. The aim of this retrospective, case series study was to describe conventional and contrast-enhanced ultrasound (using SonoVue® ) findings in a group of dogs with histologically confirmed gall bladder disease. A total of 65 dogs were included. Branchlike, heterogeneous, and homogeneous contrast enhancement of echogenic intraluminal mass-forming lesions was a contrast-enhanced ultrasound characteristic of polypoid lesions due to cystic mucosal hyperplasia of the gallbladder and/or tumor, which had different wash-in and washout characteristics...
February 2, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29393244/percutaneous-intraductal-radiofrequency-ablation-for-malignant-biliary-obstruction-caused-by-recurrence-and-metastasis-after-primary-tumor-resection
#15
Wei Cui, Wenzhe Fan, Mingjian Lu, Yingqiang Zhang, Wang Yao, Yu Wang, Jiaping Li
No abstract text is available yet for this article.
January 23, 2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29392752/increased-expression-of-senescence-associated-cell-cycle-regulators-in-the-progression-of-biliary-atresia-an-immunohistochemical-study
#16
Motoko Sasaki, Fang-Ying Kuo, Chao-Cheng Huang, Paul E Swanson, Chao-Long Chen, Jiin-Haur Chuang, Matthew M Yeh
AIMS: Cellular senescence plays a role in tumor suppression and in the pathogenesis of various non-neoplastic diseases, including primary biliary cholangitis and other adult cholangiopathies. Less is known about the role of cellular senescence in cholangiopathies in children. With that in mind, we examined the expression of senescence-associated cell cycle regulators in biliary atresia, the most common form of pediatric obliterative cholangiopathy. METHODS AND RESULTS: The expression of s senescence-associated cell cycle regulators (p16Ink4a and p21WAF1/Cip1 ) and a ductular reaction related marker (neural cell adhesion molecule - NCAM), was examined in bile ducts and bile ductules in liver samples taken from the patients with biliary atresia (n=80; including 23 samples at the time of Kasai-procedure (KP) and 63 obtained from the explanted liver (LT) [6 cases with samples at both surgical stages of disease]) and from appropriate controls (n=17)...
February 2, 2018: Histopathology
https://www.readbyqxmd.com/read/29387511/extraosseous-ewing-s-sarcoma-of-the-pancreas-an-uncommon-but-treatable-disease
#17
Muhammad W Saif, Kristin Kaley
Extraosseous Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is a rare but aggressive and malignant tumor, and has been reported in various sites such as the lungs, biliary tract, kidney, prostate, stomach, esophagus, oral cavity, salivary glands, urinary bladder, uterus, cervix, gonads, and vagina. However, the pancreas is considered to be an extremely uncommon site and only a handful of cases have been published to date. We present here another case of a pancreatic ES/PNET. Our case intensifies the importance to recognize this rare type of tumor in the pancreas as there is a broad spectrum of tumors with a similar morphology that includes sheets of small, round blue cells...
November 26, 2017: Curēus
https://www.readbyqxmd.com/read/29387397/impact-of-the-histological-phenotype-of-extrahepatic-bile-duct-carcinoma
#18
Kensuke Okano, Tadashi Yoshizawa, Takuya Miura, Keinosuke Ishido, Daisuke Kudo, Norihisa Kimura, Tai-Ichi Wakiya, Yunyan Wu, Satoko Morohashi, Kenichi Hakamada, Hiroshi Kijima
The classification of histological phenotypes was originally conceived for pancreatic intraductal papillary mucinous neoplasms. Recently, it has been introduced for extrahepatic cholangiocarcinoma. The aim of the present study was to clarify the associations between histological phenotype and clinicopathological features of extrahepatic cholangiocarcinoma, using 99 cases of surgically-resected extrahepatic cholangiocarcinoma. All cases were divided into one of two histological phenotypes: Biliary-type (BT; 56 cases, 56...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29379006/long-term-outcomes-of-ante-situm-resection-and-auto-transplantation-in-conventionally-unresectable-hepatocellular-carcinoma-a-single-center-experience
#19
Qifa Ye, Cheng Zeng, Yanfeng Wang, Yingzi Ming, Qiquan Wan, Shaojun Ye, Yan Xiong, Ling Li
BACKGROUND Ante-situm resection and auto-transplantation (ante-situm for short) provides a more aggressive approach to conventionally unresectable hepatocellular carcinoma (HCC). We described the long-term outcomes of patients with HCCs who underwent this technique. MATERIAL AND METHODS Between October 2005 and December 2016, we performed 23 ante-situm liver resections. We evaluated postoperative complications, 90-day mortality, recurrence, and long-term survival rates, and reviewed the literature on this topic...
January 30, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29375949/biliary-mucinous-cystic-neoplasm-of-the-liver-with-ovarian-stroma-and-elevated-serum-and-cystic-fluid-cancer-antigen-19-9-levels
#20
Georgios P Fragulidis, Eirini V Pantiora, Elissaios A Kontis, Elias Primetis, Andreas Polydorou, Eleni Karvouni, George Polymeneas
Biliary mucinous cystic neoplasms of the liver are rare cystic tumors comprising less than 5% of the liver cystic neoplasms. These tumors demonstrate a female predominance and entail a risk of malignant transformation. We present a 56-year-old female patient with a multiloculated liver cystic lesion measuring 22 cm who underwent a cystectomy with en bloc resection of the liver segments II, III, and cholecystectomy. Serum cancer antigen 19.9 was 4,122.00 U/ml, supporting the diagnosis of a biliary cystic tumor...
November 20, 2017: Curēus
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