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https://www.readbyqxmd.com/read/29661464/cauliflower-like-neoplasm-of-duodenal-papilla-in-a-liver-transplant-recipient-what-should-we-think-and-do-a-case-report
#1
D-L Wan, M-X Li, L Bao, L-L Zhang, L Zhang, Q-Y Chen, S-Z Lin
BACKGROUND: With the continuous improvement of liver transplantation technology, the survival rate of liver transplantation has been improved, but recurrent or de novo malignancy remains one of the major factors affecting the long-term survival of liver transplant recipients. CASE REPORT: A 45-year-old Chinese man had a plastic biliary stent placed on account of biliary anastomotic stenosis after 3 years of piggyback liver transplantation. He came to our hospital because of recurrent fever and jaundice for 2 weeks, and his carcinoembryonic antigen-199 had increased...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29660322/efficacy-and-safety-of-endobiliary-radiofrequency-ablation-for-the-eradication-of-residual-neoplasia-after-endoscopic-papillectomy-a-multicenter-prospective-study
#2
Marine Camus, Bertrand Napoléon, Ariane Vienne, Marc Le Rhun, Sarah Leblanc, Maximilien Barret, Stanislas Chaussade, Françoise Robin, Nadira Kaddour, Frederic Prat
BACKGROUND: and study aims: Endobiliary dysplasia may persist after endoscopic papillectomy. Intraductal radiofrequency ablation (ID-RFA) is a potential alternative to complementary surgery. The aim of the study was to evaluate the efficacy and safety of ID-RFA for the treatment of adenomatous intraductal residue after endoscopic papillectomy. PATIENTS AND METHODS: A prospective open-label multicenter study included patients with histologically proven endobiliary adenoma remnant (ductal extent <20 mm), after endoscopic papillectomy for ampullary tumor...
April 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29653120/covered-versus-uncovered-self-conformable-metal-stent-for-palliation-of-primary-malignant-extrahepatic-biliary-strictures-a-randomized-multicenter-study
#3
Massimo Conio, Benedetto Mangiavillano, Angelo Caruso, Rosa Angela Filiberti, Todd H Baron, Luca De Luca, Sergio Signorelli, Mattia Crespi, Mario Marini, Paolo Ravelli, Rita Conigliaro, Antonella De Ceglie
BACKGROUND AND AIMS: Self-expandable metal stents (SEMSs) are used to relieve malignant biliary obstruction. We aimed to compare stent patency, adverse events rate and overall survival of covered (Niti-S Biliary ComVi) versus uncovered (Niti-s D type) self-conformable metal stents in patients with primary malignant extrahepatic biliary stricture, not eligible for surgery. METHODS: This is a multicenter randomized trial analyzing 158 patients with inoperable distal malignant biliary obstruction conducted in 5 Italian referral centers between December 2014 and October 2016...
April 10, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29628495/pancreaticoduodenectomy-with-preservation-of-collateral-circulation-or-revascularization-for-biliary-pancreatic-cancer-with-celiac-axis-occlusion-a-report-of-2-cases
#4
Kazuaki Shibuya, Hirofumi Kamachi, Tatsuya Orimo, Akihisa Nagatsu, Shingo Shimada, Kenji Wakayama, Hideki Yokoo, Toshiya Kamiyama, Akinobu Taketomi
BACKGROUND In cases of celiac axis occlusion requiring pancreaticoduodenectomy for malignancy, both oncologic curability and control of hepatic arterial flow must be considered, but the operative strategy is undeveloped. CASE REPORT Case 1: A 74-year-old man was diagnosed with hilar cholangiocarcinoma with celiac axis stenosis. The collateral from the superior mesenteric artery ran through the pancreas head but no invasion was observed in preoperative imaging. Hepatopancreatoduodenectomy with preservation of a collateral was performed...
April 9, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29627364/animal-models-of-cholangiocarcinoma
#5
REVIEW
Emilien Loeuillard, Samantha R Fischbach, Gregory J Gores, Sumera Rizvi
Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with a poor overall prognosis. There is a critical need to develop effective targeted therapies for the treatment of this lethal disease. In an effort to address this challenge, preclinical in vivo studies have become paramount in understanding CCA carcinogenesis, progression, and therapy. Various CCA animal models exist including carcinogen-based models in which animals develop CCA after exposure to a carcinogen, genetically engineered mouse models in which genetic changes are induced in mice leading to CCA, murine syngeneic orthotopic models, as well as xenograft tumors derived from xenotransplantation of CCA cells, organoids, and patient-derived tissue...
April 5, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29622700/hybrid-capture-based-tumor-sequencing-and-copy-number-analysis-to-confirm-origin-of-metachronous-metastases-in-brca1-mutant-cholangiocarcinoma-harboring-a-novel-ywhaz-braf-fusion
#6
Huat C Lim, Meagan Montesion, Thomas Botton, Eric A Collisson, Sarah E Umetsu, Spencer C Behr, John D Gordan, Phil J Stephens, Robin K Kelley
Biliary tract cancers such as cholangiocarcinoma represent a heterogeneous group of cancers that can be difficult to diagnose. Recent comprehensive genomic analyses in large cholangiocarcinoma cohorts have defined important molecular subgroups within cholangiocarcinoma that may relate to anatomic location and etiology [1-4] and may predict responsiveness to targeted therapies in development [5-7]. These emerging data highlight the potential for tumor genomics to inform diagnosis and treatment options in this challenging tumor type...
April 5, 2018: Oncologist
https://www.readbyqxmd.com/read/29622390/-therapeutic-advances-in-the-management-of-biliary-tract-carcinoma
#7
Sophie-Clémentine Ribiere, Chloé Léandri, Marie-Anne Guillaumot, Catherine Brezault, Romain Coriat
Cancers of the bile ducts or cholangiocarcinomas are a rare entity whose incidence is increasing in France. Surgical resection of cholangiocarcinoma remains the only curative therapy. Adjuvant therapy with capecitabine at a fixed dose of 1250mg/m2 twice daily from day 1 to day 14 (21-day cycle) for a 6 months period is now the standard of care after curative surgery. At a metastatic stage, the reference treatment consists of the combination of a platinum salt in addition to gemcitabine. No biomarker has been identified to predict the response to chemotherapy...
April 2, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29613980/use-of-intravitreal-bevacizumab-for-the-treatment-of-secondary-glaucoma-due-to-metastatic-iris-tumor
#8
Rukiye Aydin, Tongalp H Tezel
PURPOSE: To report the efficacy of intravitreal bevacizumab to resolve secondary angle closure glaucoma caused by biliary tract carcinoma metastasis to iris. ABSTRACT: A 52-year-old Caucasian woman who was under systemic chemotherapy for biliary tract carcinoma presented with metastatic tumor in the left iris. At presentation, her visual acuity was at 20/50 level. Tumor was occupying nasal half of the iris and had already occupied 5.5 clock hours of the angle resulting intraocular pressure elevation to 34▒mm Hg...
April 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29605722/efficacy-of-eus-and-ercp-guided-biliary-drainage-for-malignant-biliary-obstruction-prospective-randomized-controlled-study
#9
Joo Kyung Park, Young Sik Woo, Donghyo Noh, Ju-Il Yang, So Young Bae, Hwan Sic Yun, Jong Kyun Lee, Kyu Taek Lee, Kwang Hyuck Lee
BACKGROUND AND AIMS: ERCP-guided biliary drainage (ERCP-BD is a criterion standard treatment for malignant biliary obstruction when curative surgery is not an option. Alternative methods such as PTBD would significantly lower the quality of life. EUS-guided biliary drainage (EUS-BD) has been developed and performed by experienced endoscopists. Therefore, the aims of this study were to evaluate the efficacy and safety of EUS-BD compared with ERCP in malignant biliary obstruction. METHODS: The prospective randomized controlled study was conducted and 30 patients were enrolled; 15 for each EUS-BD and ERCP-BD arm...
March 29, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29601088/blocking-h1-h2-histamine-receptors-inhibits-damage-fibrosis-in-mdr2-mice-and-human-cholangiocarcinoma-tumorigenesis
#10
Lindsey Kennedy, Laura Hargrove, Jennifer Demieville, Allen Karstens, Hannah Jones, Sharon DeMorrow, Fanyin Meng, Pietro Invernizzi, Francesca Bernuzzi, Gianfranco Alpini, Steven Smith, Austin Akers, Victoria Meadows, Heather Francis
BACKGROUND: Primary Sclerosing Cholangitis (PSC) patients are at risk of developing cholangiocarcinoma (CCA). We have shown that: (i) histamine (HA) increases biliary hyperplasia via H1/H2 histamine receptors (HRs) and (ii) HA levels increase and mast cells (MCs) infiltrate during PSC and CCA. We aimed to examine the effects of chronic treatment with H1/H2HR antagonists on PSC and CCA. METHODS: Wild-type and Mdr2-/- mice were treated by osmotic minipumps with saline, mepyramine or ranitidine (10mg/kg BW/day) or a combination of mepyramine/ranitidine for 4 wks...
March 30, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29599359/clinicopathological-aspects-and-diagnostic-problems-in-patients-with-intraductal-papillary-neoplasm-of-the-bile-duct
#11
Atsushi Nanashima, Naoya Imamura, Yorihisa Sumida, Masahide Hiyoshi, Takeomi Hamada, Takeshi Nagayasu
BACKGROUND/AIM: Intraductal papillary neoplasm of the bile duct (IPNB) is defined as a non-invasive malignancy and disparity of its histological diagnosis with related diseases remains. PATIENTS AND METHODS: Twenty-six cases of IPNB and 12 of papillary adenocarcinomas (PAC) at two Institutes were investigated. RESULTS: The prevalence of biliary dilatation and mucin secretion in the group with IPNB was significantly higher compared to the group with PAC (p<0...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29592868/ki67-proliferative-index-of-the-neuroendocrine-component-drives-manec-prognosis
#12
Massimo Milione, Patrick Maisonneuve, Alessio Pellegrinelli, Federica Grillo, Luca Albarello, Paola Spaggiari, Alessandro Vanoli, Giovanna Tagliabue, Eleonora Pisa, Luca Messerini, Giovanni Centonze, Frediano Inzani, Aldo Scarpa, Mauro Papotti, Marco Volante, Fausto Sessa, Nicola Fazio, Giancarlo Pruneri, Guido Rindi, Enrico Solcia, Stefano La Rosa, Carlo Capella
Mixed adeno-neuroendocrine carcinomas (MANECs) are composed of a poorly differentiated neuroendocrine carcinoma (NEC) and a non-neuroendocrine (non-NEC) neoplastic epithelial component, each representing at least 30% of the tumor. At present, prognostic factors for MANECs remain largely unexplored. We investigated the clinical-pathologic features of a large multicenter series of digestive system MANECs. Surgical specimens of 200 MANEC candidates were centrally reviewed; diagnosis was confirmed in 160 cases...
March 28, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29587959/cup-syndrome-metastatic-malignancy-with-unknown-primary-tumor
#13
Gregor Zaun, Martin Schuler, Ken Herrmann, Andrea Tannapfel
BACKGROUND: 2-4% of newly diagnosed cases of malignant disease involve cancer of unknown primary (CUP). This mixed entity is one of the 6 most common types of malignant disease in Germany. Highly refined treatment strategies can now be offered to patients with CUP. METHODS: This review is based on pertinent publications retrieved by a selective search in PubMed with an emphasis on articles from the past decade. The current guidelines and recommendations of specialty societies were also considered in the evaluation...
March 9, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29578146/human-epidermal-growth-factor-receptor-2-epidermal-growth-factor-receptor-and-c-met-overexpression-and-survival-in-biliary-tract-cancer-a-meta-analysis
#14
Wei Zhou, Congqing Jiang, Nan Zhan, Xiaoguang Lv, Lifang Fan, Maskey Ninu
Background: Tyrosine kinase growth factor receptors (TKGFRs) play an important role in the progression of cancer. A variety of studies have investigated the clinicopathologic correlation of these receptors and their influences on patient survival in different types of cancer. As the members of TKGFRs, the biomarkers c-MET, epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER-2) have been extensively investigated in biliary tract cancer (BTC). However, their prognostic value is still controversial...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29575299/the-plgf-c-myc-mir-19a-axis-promotes-metastasis-and-stemness-in-gallbladder-cancer
#15
Huaifeng Li, Yunpeng Jin, Yunping Hu, Lin Jiang, Fatao Liu, Yijian Zhang, Yajuan Hao, Shili Chen, Xiangsong Wu, Yingbin Liu
Gallbladder cancer (GBC) is the most common malignant tumor of the biliary track system. Epithelial-mesenchymal transition (EMT) plays a vital role in the process of tumor metastasis. Mesenchymal-like cells can serve as a source of cancer stem cells (CSCs), which can confer the EMT phenotype. Placental growth factor (PLGF) belongs to the VEGF family and plays a vital role in cancer. However, the underlying molecular mechanisms about the influence of PLGF on EMT in GBC remain unknown. Here we show that PLGF expression levels were higher in GBC tissues than in normal adjacent tissues (NATs) and were associated with poor prognosis in GBC patients...
March 25, 2018: Cancer Science
https://www.readbyqxmd.com/read/29573187/propensity-matched-analysis-of-patients-with-mixed-hepatocellular-cholangiocarcinoma-and-hepatocellular-carcinoma-undergoing-liver-transplantation
#16
Keri E Lunsford, Colin Court, Yong Seok Lee, David S Lu, Bita V Naini, Michael P Harlander-Locke, Ronald W Busuttil, Vatche G Agopian
Mixed hepatocellular-cholangiocarcinomas (HCC-CCA) are rare tumors with both hepatocellular and biliary differentiation. While liver transplantation (LT) is the gold standard treatment for patients with unresectable hepatocellular carcinoma (HCC), it is contraindicated in known HCC-CCA due to concerns of poor prognosis. We sought to compare post-transplant oncologic outcomes for HCC-CCA and a matched cohort of HCC LT recipients. METHODS: A retrospective, single-center analysis (1984-2015) identified 12 patients with mixed HCC-CCA who were matched 1:3 to patients with HCC on both pretransplant (radiologic diameter and AFP) and explant (pathologic diameter, grade/differentiation, and vascular invasion) tumor characteristics...
March 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29573058/molecular-genomic-landscapes-of-hepatobiliary-cancer
#17
REVIEW
Tatsuhiro Shibata, Yasuhito Arai, Yasushi Totoki
Hepatocellular carcinoma (HCC) and biliary tract cancer (BTC) are more frequent in East Asia including Japan. Compiling 1,340 multi-ethnic HCC genomes, the largest cohort ever reported, identified comprehensive landscape of HCC driver genes, which constitutes three core drivers (TP53, TERT and WNT signaling) and combination of infrequent alterations in various cancer pathways. By contrast, five core driver genes (TP53, ARID1A, KRAS, SMAD4 and BAP1) with characteristic molecular alterations including fusion transcripts involving FGFR2 and the PKA pathway, and IDH1/2 mutation constituted the BTC genomes...
March 23, 2018: Cancer Science
https://www.readbyqxmd.com/read/29572828/the-prognostic-impact-of-differentiation-at-the-invasive-front-of-biliary-tract-cancer
#18
Satoshi Okubo, Shuichi Mitsunaga, Yuichiro Kato, Motohiro Kojima, Motokazu Sugimoto, Naoto Gotohda, Shinichiro Takahashi, Ryuichi Hayashi, Masaru Konishi
BACKGROUND: The invasive front of tumor can provide prognostic information in many cancers. We investigated the prognostic morphological factors at the invasive front including tumor differentiation (Difinv ) and tumor budding (Bud) in biliary tract cancer (BTC). METHODS: The resected specimen from the 299 BTC patients were examined. Intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, gallbladder cancer, and ampulla of Vater cancer were found in 16%, 48%, 17%, and 19%, respectively...
March 24, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29569755/ldha-is-a-direct-target-of-mir-30d-5p-and-contributes-to-aggressive-progression-of-gallbladder-carcinoma
#19
Yuting He, Xiaolong Chen, Yan Yu, Juan Li, Qiuyue Hu, Chen Xue, Jianan Chen, Shen Shen, Yonggang Luo, Fang Ren, Chao Li, Jie Bao, Jingya Yan, Guowu Qian, Zhigang Ren, Ranran Sun, Guangying Cui
Gallbladder cancer (GBC) is the most general biliary tract malignancy, with poor prognosis due to rapid tumor progression and lack of specific symptoms. Lactate dehydrogenase-A (LDHA) can promote Warburg effect to produce lactate and Adenosine Triphosphate (ATP) in aerobic condition, which contributes to oncogenesis metastasis and drug resistance in various cancers. However, the expression and functional role of LDHA in GBC are largely unknown. We determined that LDHA was over-expressed in GBC tumor tissues compared with normal tissues, which was also an independent prognostic factor for the overall survival of GBC patients by tissue microarrays analysis...
March 23, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29567877/a-practical-diagnostic-approach-to-hepatic-masses
#20
REVIEW
Monika Vyas, Dhanpat Jain
The differential diagnosis of hepatic mass lesions is broad and arriving at the right diagnosis can be challenging, especially on needle biopsies. The differential diagnosis of liver tumors in children is different from adults and is beyond the scope of this review. In adults, the approach varies depending on the age, gender, and presence of background liver disease. The lesions can be divided broadly into primary and metastatic (secondary), and the primary lesions can be further divided into those of hepatocellular origin and nonhepatocellular origin...
January 2018: Indian Journal of Pathology & Microbiology
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