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https://www.readbyqxmd.com/read/29898439/the-diagnostic-accuracy-of-cytology-for-the-diagnosis-of-hepatobiliary-and-pancreatic-cancers
#1
Marwan Al-Hajeili, Maryam Alqassas, Astabraq Alomran, Bashaer Batarfi, Bashaer Basunaid, Reem Alshail, Shahad Alaydarous, Rana Bokhary, Mahmoud Mosli
OBJECTIVE: Although cytology testing is considered a valuable method to diagnose tumors that are difficult to access such as hepato-biliary-pancreatic (HBP) malignancies, its diagnostic accuracy remains unclear. We therefore aimed to investigate the diagnostic accuracy of cytology testing for HBP tumors. STUDY DESIGN: We performed a retrospective study of all cytology samples that were used to confirm radiologically detected HBP tumors between 2002 and 2016. The cytology techniques used in our center included fine needle aspiration (FNA), brush cytology, and aspiration of bile...
June 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29896581/a-long-term-survival-case-of-advanced-biliary-cancer-with-repeated-resection-due-to-recurrence-in-the-pancreaticogastrostomy-site-after-pancreaticoduodenectomy
#2
Shohei Eto, Masashi Ishikawa, Michihito Asanoma, Yoshihiko Tashiro, Kazuo Matsuyama, Takehito Oshio
A 62-year-old man underwent endoscopic mucosal resection for early gastric cancer. The follow-up computed tomography revealed biliary dilatation. The tumor was located in the lower bile duct with biliary dilatation, and no evidence of metastasis in other organs was noted. The patient underwent subtotal stomach-preserving pancreatoduodenectomy with pancreaticogastrostomy and Billroth I anastomosis. At 13 months after the operation, gastrointestinal endoscopy revealed a tumor lesion in the pancreaticogastrostomy site...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29896580/two-cases-of-bronchobiliary-fistula-case-report
#3
Jae Ryong Shim, Sung-Sik Han, Hyung Min Park, Eung Chang Lee, Sang-Jae Park, Joong-Won Park
A bronchobiliary fistula, or a biliobronchial fistula (BBF), is a rare condition. It results from an abnormal connection between the biliary and bronchial trees, and is characterized by pathognomonic bilious sputum with suspicious pneumonia. Traditionally, an infectious disease, such as a hydatid infection, has been known to cause a BBF, but BBFs have recently become associated with tumors. In every case, procedures and treatments differ between centers, from simple conservative management to invasive surgical procedures...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29896570/extracapsular-excision-of-hepatic-hemangioma-a-single-centre-experience
#4
Amol Kanetkar, Shubham Garg, Shraddha Patkar, Rajesh S Shinde, Mahesh Goel
Backgrounds/Aims: Hepatic hemangioma is a common non-epithelial neoplasm of the liver. Presence of symptoms and uncertainty in diagnosis are the most common indications for surgery. Methods: Eighteen patients with hepatic hemangioma, operated on from January 2011 to December 2016 at the Hepato-pancreato-biliary surgical unit of Tata Memorial Hospital, were retrospectively analyzed. Results: Main indications for operation were presence of symptoms, the most common being pain and diagnostic uncertainty...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29891702/bright-quantum-dots-emitting-at-%C3%A2-1-600-nm-in-the-nir-iib-window-for-deep-tissue-fluorescence-imaging
#5
Mingxi Zhang, Jingying Yue, Ran Cui, Zhuoran Ma, Hao Wan, Feifei Wang, Shoujun Zhu, Ying Zhou, Yun Kuang, Yeteng Zhong, Dai-Wen Pang, Hongjie Dai
With suppressed photon scattering and diminished autofluorescence, in vivo fluorescence imaging in the 1,500- to 1,700-nm range of the near-IR (NIR) spectrum (NIR-IIb window) can afford high clarity and deep tissue penetration. However, there has been a lack of NIR-IIb fluorescent probes with sufficient brightness and aqueous stability. Here, we present a bright fluorescent probe emitting at ∼1,600 nm based on core/shell lead sulfide/cadmium sulfide (CdS) quantum dots (CSQDs) synthesized in organic phase...
June 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29891522/clinical-impact-of-local-progression-in-pancreatic-cancer
#6
Nicholas Cardillo, Daniel M Seible, Katherine E Fero, Andrew R Bruggeman, Reith R Sarkar, Alexa Azuara, Daniel R Simpson, James D Murphy
Background: The high prevalence of distant metastatic disease among patients with pancreatic cancer often draws attention away from the local pancreatic tumor. This study aimed to define the complications and hospitalizations from local versus distant disease progression among a retrospective cohort of patients with pancreatic cancer. Methods: Records of 298 cases of pancreatic cancer treated at a single institution from 2004 through 2015 were retrospectively reviewed, and cancer-related symptoms and complications requiring hospitalization were recorded...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29868141/role-of-multidetector-computed-tomography-mdct-in-evaluation-of-gallbladder-malignancy-and-its-pathological-correlation-in-an-indian-rural-center
#7
Gunjan Jindal, Samita Singal, Birinder Nagi, Amit Mittal, Shallini Mittal, Rikki Singal
Objectives: Clinically or sonographically suspected gallbladder carcinoma was evaluated on multidetector computed tomography. Based on the spectrum of multidetector computed tomography findings, staging of gallbladder carcinoma was done. Multidetector computed tomography diagnosis was compared with pathological diagnosis. Material and methods: This is a prospective study carried out in 100 patients at a rural Indian center between May 2012 and June 2015. Multidetector computed tomography was performed in all the cases and the findings were observed...
March 2018: Mædica
https://www.readbyqxmd.com/read/29863124/occupational-cholangiocarcinoma-caused-by-exposure-to-1-2-dichloropropane-and-or-dichloromethane
#8
REVIEW
Shoji Kubo, Shigekazu Takemura, Shogo Tanaka, Hiroji Shinkawa, Masahiko Kinoshita, Genya Hamano, Tokuji Ito, Masaki Koda, Takanori Aota
A cluster of cholangiocarcinoma among printing company workers who were exposed to 1,2-dichloropropane and/or dichloromethane was classified by the Ministry of Health, Labour and Welfare of Japan on 1 October 2013 as "occupational cholangiocarcinoma". At the time of the diagnosis of cholangiocarcinoma, levels of γ-glutamyl transferase, and aspartate and alanine aminotransferases were elevated, and had been elevated in some patients several years prior to the diagnosis. Regional dilatation of intrahepatic bile ducts without tumor-induced obstruction was characteristic in diagnostic imaging...
March 2018: Annals of gastroenterological surgery
https://www.readbyqxmd.com/read/29850295/microwave-thermal-ablation-in-an-unusual-case-of-malignant-and-locally-advanced-rare-tumor-of-pancreas-in-asa-iv-old-male-patient-and-literature-review
#9
Francesco D'Amico, Michele Finotti, Chiara Di Renzo, Alessio Pasquale, Alessandra Bertacco, Giorgio Caturegli, Gabriel E Gondolesi, Umberto Cillo
Pancreatic intraductal papillary-mucinous neoplasm is a rare primary neoplasm of unknown pathogenesis. This kind of tumor represents 0.2-2.7% of all pancreatic cancers and they may proceed to malignant lesions. In this study, we describe a case of pancreatic intraductal papillary-mucinous tumor (4.3 cm) with normal tumoral markers and nuclear atypia. We perform also a systematic review of the literature on MEDLINE and find only one relevant study that used microwave ablation for the palliative treatment of pancreatic tumor...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29848810/centrally-located-small-unifocal-hepatocellular-carcinoma-between-minor-conservative-liver-resection-and-major-hepatectomy-case-reports
#10
Emilio De Raffele, Mariateresa Mirarchi, Carmelo Antonio Caserta, Dajana Cuicchi, Gaspare Maria Pendino, Ferdinando Lecce, Stefano Cariani, Bruno Cola
Hepatocellular carcinoma (HCC) is one of the leading cancer in the world, susceptible to potentially curative liver resection (LR) in selected cases. Centrally located HCC (CL-HCC) are sited in central liver segments and may require complex LR because of their relationship to major vascular and biliary structures and deep parenchymal location. Even though extended segment-oriented resections are recommended for oncological reasons, more conservative LR may be indicated in patients with cirrhosis to preserve an adequate function of the future remnant liver (FRL)...
2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29848569/comprehensive-molecular-profiling-of-intra-and-extrahepatic-cholangiocarcinomas-potential-targets-for-intervention
#11
Maeve A Lowery, Ryan N Ptashkin, Emmet J Jordan, Michael F Berger, Ahmet Zehir, Marinela Capanu, Nancy E Kemeny, Eileen M O'Reilly, Imane El Dika, William R Jarnagin, James J Harding, Michael I D'Angelica, Andrea Cercek, Jaclyn F Hechtman, David B Solit, Nikolaus Schultz, David M Hyman, David S Klimstra, Leonard Saltz, Ghassan K Abou-Alfa
PURPOSE: Various genetic driver aberrations have been identified among distinct anatomic and clinical subtypes of intrahepatic and extrahepatic cholangiocarcinoma, and these molecular alterations may be prognostic biomarkers and/or predictive of drug response. EXPERIMENTAL DESIGN: Tumor samples from patients with cholangiocarcinoma who consented prospectively were analyzed using the MSK-IMPACT platform, a targeted next generation sequencing assay that analyzes all exons and selected introns of 410 cancer-associated genes...
May 30, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29805823/tubulocystic-carcinoma-of-the-bile-duct
#12
Masahiro Takeuchi, Yoshitaka Sakamoto, Hirotsugu Noguchi, Sohsuke Yamada, Keiji Hirata
Tubulocystic carcinoma of the bile duct is extremely rare and has not been reported in the literature. We reported a case of cystic neoplasm of the liver with distinct histopathological features that could not be clearly classified as of either mucinous or intraductal papillary neoplasm. A 68-year-old Japanese patient had a multicystic biliary tumor within the liver. This tumor was detected on follow-up of polymyalgia rheumatica. The exophytic, multicystic, 35 × 50 mm mass was composed of complex tubulocystic structures...
2018: Case Reports in Hepatology
https://www.readbyqxmd.com/read/29805739/prognostic-value-of-cd8cd45ro-tumor-infiltrating-lymphocytes-in-patients-with-extrahepatic-cholangiocarcinoma
#13
Richard Kim, Domenico Coppola, Emilie Wang, Young Doo Chang, Yuhree Kim, Daniel Anaya, Dae Won Kim
Cholangiocarcinoma is a malignancy arising from the biliary tract epithelial cells with poor prognosis. Tumor infiltrating lymphocytes (TIL)s and programmed cell death receptor ligand 1 (PD-L1) have a prognostic impact in various solid tumors. We aimed to investigate TILs and PD-L1 expression and their clinical relevance in cholangiocarcinoma. Tumor samples from 44 patients with resected and histologically verified extrahepatic cholangiocarcinoma were evaluated for CD8, CD45RO and PD-L1 expression, and their correlations with clinicopathological data and survival data were analyzed...
May 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/29792748/portal-vein-thrombosis-imaging-the-spectrum-of-disease-with-an-emphasis-on-mri-features
#14
Reena C Jha, Satinderpal Singh Khera, Amit Dinesh Kalaria
OBJECTIVE: The purpose of this article is to review the classic and uncommon imaging findings of portal vein thrombosis (PVT) (acute, chronic, congenital, and septic thrombus) as visualized on multiple modalities, with an emphasis on MRI findings. Additional aims are to understand the imaging of obliterative portal venopathy and its clinical significance, appreciate morphologic changes of the biliary system that may accompany PVT, and recognize changes in liver enhancement patterns seen with PVT related to the hepatic arterial buffer response...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29791202/different-mr-features-for-differentiation-of-intrahepatic-mass-forming-cholangiocarcinoma-from-hepatocellular-carcinoma-according-to-tumor-size
#15
Ting Ni, Xiao-Sha Shang, Wen-Tao Wang, Xin-Xing Hu, Meng-Su Zeng, Sheng-Xiang Rao
OBJECTIVE: To identify reliable magnetic resonance (MR) features for distinguishing IMCC from hepatocellular carcinoma (HCC) based on tumor size. METHODS: This retrospective study included 395 patients with pathologically confirmed IMCCs (n = 180) and HCCs (n = 215) who underwent preoperative contrast-enhanced MR imaging including diffusion weighted imaging (DWI). MR features were evaluated and clinical data were also recorded. All the characteristics were compared in small (≤3 cm) and large tumor (>3 cm) groups by univariate analysis and subsequently calculated by multivariable logistic regression analysis...
May 23, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29785570/phase-1b-investigation-of-the-mek-inhibitor-binimetinib-in-patients-with-advanced-or-metastatic-biliary-tract-cancer
#16
R S Finn, D H Ahn, M M Javle, B R Tan, C D Weekes, J C Bendell, A Patnaik, G N Khan, D Laheru, R Chavira, J Christy-Bittel, E Barrett, M B Sawyer, Tanios S Bekaii-Saab
Background The MAPK pathway plays a central role in regulation of several cellular processes, and its dysregulation is a hallmark of biliary tract cancer (BTC). Binimetinib (MEK162), a potent, selective oral MEK1/2 inhibitor, was assessed in patients with advanced BTC. Patients and Methods An expansion cohort study in patients who received ≤1 line of therapy for advanced BTC was conducted after determination of the maximum tolerated dose in this Phase 1 trial. Patients received binimetinib 60 mg twice daily...
May 22, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29784432/outcome-quality-standards-in-pancreatic-oncologic-surgery-in-spain
#17
Luis Sabater, Isabel Mora, Juan Manuel Gámez Del Castillo, Javier Escrig-Sos, Elena Muñoz-Forner, Marina Garcés-Albir, Dimitri Dorcaratto, Joaquín Ortega
INTRODUCTION: To establish quality standards in oncologic surgery is a complex but necessary challenge to improve surgical outcomes. Unlike other tumors, there are no well-defined quality standards in pancreatic cancer. The aim of this study is to identify quality indicators in pancreatic oncologic surgery in Spain as well as their acceptable limits of variability. METHODS: Quality indicators were selected based on clinical practice guidelines, consensus conferences, reviews and national publications on oncologic pancreatic surgery between the years 2000 and 2016...
May 18, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29779756/biliary-cystadenoma-associated-with-opisthorchis-viverrini-infection-in-a-domestic-cat-felis-catus
#18
Saruda Tiwananthagorn, Saralee Srivorakul, Varangpicha Khochakul, Kidsadagon Pringproa
A 12-year-old, female, domestic cat (Felis catus) presented with dehydration, emaciation, anorexia, and lethargy. The cat was unresponsive to medical treatment and euthanized; the carcass was submitted for pathological diagnosis. Necropsy revealed icteric mucous membranes. The liver was enlarged, with multinodular, cystic, white masses, 0.5-4.0 cm in diameter, scattered throughout. Microscopically, the biliary epithelium presented with a proliferation of multifocal cystic masses, occasionally with periodic acid-Schiff-positive fluid within the cysts...
May 5, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29779313/-curative-effect-analysis-of-bile-reinfusion-combined-with-enteral-nutrition-support-before-surgery-of-hilar-cholangiocarcinoma
#19
P Song, L Mao, X J Bian, T Zhou, Y Y Fan, J Zhang, M Xie, Y D Qiu
Objective: To investigate the clinical effect of bile reinfusion combined with enteral nutrition support before surgery for hilar cholangiocarcinoma. Methods: A retrospective analysis of patients with hilar cholangiocarcinoma who underwent surgical treatment at Nanjing Drum Tower Hospital Hepato-biliary-pancreatic Surgery Department from July 2010 to August 2017 was completed.A total of 52 cases were finally enrolled in our study.All the patients included, on the basis of whether they received preoperative drainage and bile reinfusion, were divided into non-drainage group( n =15) and drainage group( n =37)...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29778567/emp3-which-is-regulated-by-mir-663a-suppresses-gallbladder-cancer-progression-via-interference-with-the-mapk-erk-pathway
#20
Qiang Ma, Yijian Zhang, Haibin Liang, Fei Zhang, Fatao Liu, Shili Chen, Yunping Hu, Lin Jiang, Yajuan Hao, Maolan Li, Yingbin Liu
Gallbladder cancer (GBC) is the most common malignancy of the biliary tract and its molecular pathogenesis is poorly understood. Aberrant expression of epithelial membrane protein-3 (EMP3) was reported in different kinds of cancers. Our study aimed to explore the elusive functional roles and the underlying molecular mechanisms of EMP3 with respect to GBC progression. The results showed that human GBC tissues exhibited decreased levels of EMP3 compared with non-malignant tissues. Kaplan-Meier analysis indicated that low expression of EMP3 was associated with poor prognosis of GBC patients...
May 17, 2018: Cancer Letters
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