Awesome

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Awe arises when one experiences something so extraordinary that it defies current understanding, prompting efforts to comprehend the initially incomprehensible. We situate awe within Dubourg and Baumard's framework for the prevalence and psychological underpinnings of imaginary worlds. We argue that imaginary worlds are powerful catalysts of awe, which, in turn, drive important individual and social outcomes.

Stability-indicating methods are awesome tools to ensure the safety and efficacy of active pharmaceutical ingredients (APIs). An accurate comparative study involving the use of potentiometric sensors for the determination of bromazepam (BRZ) in the presence of its main product of degradation and impurity was performed by the fabrication of two membrane electrodes. A screen-printed electrode (SPE) and a solid-contact glassy carbon electrode (SCE) were fabricated and their performance optimized. The fabricated sensors showed a linear electrochemical response in the concentration range 1...

The human complement system, an essential component of innate immunity, is a prodigy of biological evolution. The notion of complement inhibition is awesome, but some of the results achieved in therapy of serious diseases have been spectacular. Currently several pharmacological options are already available, and more are in the offing: it will be ever more important that they are optimally used in terms of safety and of therapeutic efficacy. This article is protected by copyright. All rights reserved.

Radiation protection is one of the most essential efforts for radiologists. The newest update of medical radiation protection in Japan focused on the field of interventional radiology. In this situation, it is required to choose for interventional radiologists to participate in it reluctantly or proactively. To enhance the value of interventional radiology in society, our effort of commitment to learning, collaborating, and assuming our awesome responsibility is requested. We will contribute to the safety of medical facilities and society...

OBJECTIVE: Standardized letters of recommendation (SLOR) are hypothesized to decrease bias and provide consistent domains for evaluation. However, their ability to differentiate among applicants is unknown. The utilization and functionality of SLOR and the impact of SLOR domain rating on matching for colon and rectal surgery (CRS) residency applicants have yet to be assessed. DESIGN: Descriptive statistics and bivariate analysis were employed. Applicants were categorized into 3 groups; Top-tier(TT): applicants rated 100% Excellent/Very Good; Mid-Tier(MT) applicants rated 80-99% Excellent/Very Good; and Non-Top Tier(NTT) applicants rated <80% Excellent/Very Good...

Astronomical events such as solar eclipses have played a transformative role in human social collectives as sources of collective wonder, inspiration, and reconciliation. Do celestial phenomena systematically shape individuals and their groups? Guided by scientific treatments of awe as an experience that helps individuals form into collectives, we used Twitter data ( N = 2,891,611 users) to examine the social impact of a historic, awe-inspiring celestial event: the 2017 solar eclipse. Relative to individuals residing outside the eclipse's path, individuals inside it exhibited more awe and expressed less self-focused and more prosocial, affiliative, humble, and collective language (Study 1)...

Photoacoustic imaging and photothermal therapy that employ organic dye in the second near-infrared window (NIR-II) became an attractive theranostical strategy for eliminating solid tumors, in which IR1048 was previously reported to be a good candidate. However, the further biomedical application of IR1048 was blocked by its poor water-solubility and lack of tumor-targeting. To solve this problem, liposome camouflaged with 4T1 cell membrane fragments was employed to encapsulate IR1048 (thereafter called MLI), and its application for photoacoustic and thermo-imaging and photothermal therapy were explored in vitro and in vivo...

BACKGROUND: Pulmonary vein isolation (PVI) implies unavoidable ablation lesions to the left atrial posterior wall, which is closely related to the esophagus, leading to several potential complications. This study evaluates the usefulness of the esophageal fingerprint in avoiding temperature rises during paroxysmal atrial fibrillation (PAF) ablation. METHODS: Isodistance maps of the atrio-esophageal relationship (esophageal fingerprint) were derived from the preprocedural computerized tomography...

Appropriate concepts of reconstruction can eliminate contraindications, reduce the incidence of complications, increase the success rates, and promote the outcomes. Besides, appropriate concepts can also help economical use of expensive technology or assistant tools on the patients who are necessary and beneficial. This paper provides a comprehensive approach to select reconstructive methods for oral defects following ablative surgery. A comprehensive approach should have a thorough understanding of the reconstructive goals, the patient's information, the surgeon's ability, and the hospital's support...

Since the identification of sickle cell trait as a heritable form of resistance to malaria, candidate gene studies, linkage analysis paired with sequencing, and genome-wide association (GWA) studies have revealed many examples of genetic resistance and susceptibility to infectious diseases. GWA studies enabled the identification of many common variants associated with small shifts in susceptibility to infectious diseases. This is exemplified by multiple loci associated with leprosy, malaria, HIV, tuberculosis, and coronavirus disease 2019 (COVID-19), which illuminate genetic architecture and implicate pathways underlying pathophysiology...

For decades, budding yeast, a single-cellular eukaryote, has provided remarkable insights into human biology. Yeast and humans share several thousand genes despite morphological and cellular differences and over a billion years of separate evolution. These genes encode critical cellular processes, the failure of which in humans results in disease. Although recent developments in genome engineering of mammalian cells permit genetic assays in human cell lines, there is still a need to develop biological reagents to study human disease variants in a high-throughput manner...

Cinderella: the AWESOME Truth is a children's theatrical production developed with the aim of promoting positive body image and improved self-image. As part of the production's initial run at the Polka Theatre in London, United Kingdom, we conducted an evaluation of the show's efficacy at improving state positive body image and self-image. Using a single-arm design, we recruited 54 girls and 45 boys between the ages of 5 and 9 years attending a performance of Cinderella with their parents/caregivers, and asked them to complete an adapted measure of state body appreciation at pre- and post-attendance...

We honour a great man and a true giant. Lodewyk H.S. van Mierop (March 31, 1927 - October 17, 2021), known as Bob, was not only a Paediatric Cardiologist but also a dedicated Scientist. He made many significant and ground-breaking contributions to the fields of cardiac anatomy and embryology. He was devoted as a teacher, spending many hours with medical students, Residents, and Fellows, all of whom appreciated his regularly scheduled educational sessions. Those of us who were fortunate to know and spend time with him will always remember his great mind, his willingness to share his knowledge, and his ability to encourage spirited and fruitful discussions...

As chief of surgery at Grady Memorial Hospital in Atlanta Roger Sherman trained generations of trauma surgeons, including me. Our relationship had three phases, each with a specific lesson that stayed with me throughout my career: first, the interview for a fellowship; second, my training at Grady, or "Grady 101;" and third, relating to important people outside of surgical practice, which I understood to be "that 10 percent" that really, really disliked me.I was caught during a time when there was a severe contraction of the number of training programs in surgery...

BACKGROUND: Electronic records could improve quality and efficiency of health care. National and international bodies propagate this belief worldwide. However, the evidence base concerning the effects and advantages of electronic records is questionable. The outcome of health care systems is influenced by many components, making assertions about specific types of interventions difficult. Moreover, electronic records itself constitute a complex intervention offering several functions with possibly positive as well as negative effects on the outcome of health care systems...

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The low rate of help-seeking and high rate of suicide completion among men has prompted public health officials to create suicide prevention campaigns that specifically target men. Drawing from data collected as part of a larger study of fire recovery in a rural county in Northern California, this paper utilizes 68 interviews with fire survivors (24 men and 44 women) and 40 interviews with mental health service providers to examine how rural residents interpret this type of campaign. To track patterns of help-seeking over time, I also draw upon 26 follow-up interviews - 20 with fire survivors (7 men and 13 women) and 6 with service providers - conducted one year after the first wave of interviews...

Background: The current coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global outbreak of a disease from a new coronavirus. Several databases have been published on this pandemic, but the research community still needs an easy way to get comprehensive information on COVID-19. Objectives: COVID-19 pandemic database (CO-19 PDB) aims to provide wonderful insights for COVID-19 researchers with the well-gathered of all the COVID-19 data to one platform, which is a global challenge for the research community these days...

Anna University (AU) is an awesome alma mater for attracting the attention of the invincible through awareness from education. It is a place with a plan for preparing a palace in a person's life. It is an avenue for America through adequate cGPA and Advanced GRE (AGRE) with good TOEFL score. The views,visions, modes and models of several faculty members shaped many technocrats, teachers, entrepreneurs, journalists, editors and even farmers. Technology is engineering with science. The foundation and facilities at AU is priceless...