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JOURNAL ARTICLE
Sofia Rachad, Dane Nickel, Fiona Berry, Meghan Goddard, Ayesha Khan, Natalie Muratori, Saul Hymes, Ashar Ata, Christopher Woll
OBJECTIVES: Hyperpyrexia has been associated with a greater prevalence of bacterial infections in the pediatric population, which prior to routine childhood vaccinations, has led to invasive testing and empiric antibiotic use for urinary tract infections, bacterial pneumonia, bacteremia, and bacterial meningitis. Since the implementation of routine childhood vaccinations, the prevalence of serious bacterial infections (SBIs) has declined. This study aims to determine if there is an association between hyperpyrexia and serious bacterial infections in well-appearing febrile pediatric patients presenting to the emergency department (ED)...
April 2024: Journal of the American College of Emergency Physicians open
#22
JOURNAL ARTICLE
Julie-Kathryn Graham, Danisha Jenkins, Kalie Iris, Morgan Knudsen, Christina Kelley
Significant morbidity and mortality from COVID-19-related illnesses have been observed among people of color within the United States. While theories involving healthcare inequity and political division have emerged to explain this observation, the role of chronic stress and inflammation is also being explored. Toxic stress is experienced disproportionately by race, ethnicity, and socioeconomic status and increases frailty and vulnerability to diseases such as COVID-19. C-reactive protein (CRP) is a biomarker associated with the inflammatory response that is typically elevated due to exposure to acute or chronic traumatic stress, as well as COVID-19...
March 7, 2024: Clinical Nursing Research
#23
JOURNAL ARTICLE
Adnan Mannan, Kallyan Chakma, Gourab Dewan, Ayan Saha, Naim Uddin Hasan A Chy, H M Hamidullah Mehedi, Amzad Hossain, Jannatun Wnaiza, Md Tanveer Ahsan, Md Mashud Rana, Nazmul Alam
OBJECTIVES: Self-medication with antibiotics (SMA) contributes significantly to the emergence of antimicrobial resistance (AMR), especially in low-income countries including Bangladesh. This study aimed to generate evidence on the self-reported prevalence of antibiotic self-medication and its determinants among indigenous people residing in Bangladesh's Chittagong Hill Tracts (CHT) districts. DESIGN: This study used a cross-sectional design with data collected through a survey using a semi-structured questionnaire...
March 5, 2024: BMJ Open
#24
JOURNAL ARTICLE
Stefanie G Ames, Aline B Maddux, Lauren Burgunder, Huong Meeks, Erica L Fink, Kathleen L Meert, Matt S Zinter, Peter M Mourani, Joseph A Carcillo, Todd Carpenter, Murray M Pollack, Manvita Mareboina, Daniel A Notterman, Anil Sapru
OBJECTIVES: To describe family healthcare burden and health resource utilization in pediatric survivors of acute respiratory distress syndrome (ARDS) at 3 and 9 months. DESIGN: Secondary analysis of a prospective multisite cohort study. SETTING: Eight academic PICUs in the United States (2019-2020). PATIENTS: Critically ill children with ARDS and follow-up survey data collected at 3 and/or 9 months after the event. INTERVENTIONS: None...
March 6, 2024: Pediatric Critical Care Medicine
#25
JOURNAL ARTICLE
Gamzepelin Aksoy, Grégoire Cattan, Subrata Chakraborty, Murat Karabatak
Schizophrenia is a serious chronic mental disorder that significantly affects daily life. Electroencephalography (EEG), a method used to measure mental activities in the brain, is among the techniques employed in the diagnosis of schizophrenia. The symptoms of the disease typically begin in childhood and become more pronounced as one grows older. However, it can be managed with specific treatments. Computer-aided methods can be used to achieve an early diagnosis of this illness. In this study, various machine learning algorithms and the emerging technology of quantum-based machine learning algorithm were used to detect schizophrenia using EEG signals...
March 5, 2024: Journal of Medical Systems
#26
JOURNAL ARTICLE
Chenhao Guo, Yuze Zhang, Wenhan Dong, Bo Huang, Yinghai Liu
Achilles tendon ruptures are common in athletes, requiring surgical intervention. However, the risk of surgical site infections (SSIs) post-surgery poses significant challenges. This study aims to analyse the risk factors and microbial aetiology associated with SSIs in athletes undergoing Achilles tendon repair. A comprehensive retrospective analysis was conducted from May 2021 to July 2023. The study included 25 patients with SSIs (case group) and 50 patients without SSIs (control group) post Achilles tendon repair surgery...
March 2024: International Wound Journal
#27
JOURNAL ARTICLE
Yoav Kan-Tor, Lior Ness, Liran Szlak, Felix Benninger, Sivan Ravid, Michal Chorev, Michal Rosen-Zvi, Yishai Shimoni, Robert S Fisher
Epilepsy is a severe chronic neurological disease affecting 60 million people worldwide. Primary treatment is with anti-seizure medicines (ASMs), but many patients continue to experience seizures. We used retrospective insurance claims data on 280,587 patients with uncontrolled epilepsy (UE), defined as status epilepticus, need for a rescue medicine, or admission or emergency visit for an epilepsy code. We conducted a computational risk ratio analysis between pairs of ASMs using a causal inference method, in order to match 1034 clinical factors and simulate randomization...
March 2024: Epilepsy Research
#28
JOURNAL ARTICLE
Jinxi Yue, Linjun Wan, Gang Wang, Ruiling Zhang, Xiaoran Zhang, Ouya Liu, Xiaofan Yu, Qingqing Huang, Zongfang Ren
OBJECTIVE: To analyze the predictive value of von Willebrand factor (vWF) for venous thromboembolism (VTE) of patients in intensive care unit (ICU) by using propensity score matching (PSM). METHODS: Patients admitted to ICU of the Second Affiliated Hospital of Kunming Medical University from December 2020 to June 2022 who stayed in ICU for ≥72 hours and underwent daily bedside vascular ultrasound screening were included. Baseline data such as age, gender, primary disease, and chronic comorbidities were collected...
January 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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JOURNAL ARTICLE
Xiaofei Zhu, Jiao Wang, Huibin Pan, Zhuquan Dai, Chaohui Ji, Chunmiao Zhong, Haiping Huang
OBJECTIVE: To clarify the application effect of information-guided enteral nutrition-associated diarrhea (ENAD) management process in patients with chronic obstructive pulmonary disease (COPD) undergoing non-invasive assisted ventilation. METHODS: A mixed cohort study of pre- and post-control was conducted. Thirty-nine patients with COPD who were admitted to the emergency intensive care unit (ICU) of Huzhou First People's Hospital from July 1, 2021 to July 31, 2022 were enrolled...
January 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
#30
JOURNAL ARTICLE
Kazuhito Sakuramoto, Daiki Wada, Shuhei Maruyama, Takashi Muroya, Fukuki Saito, Yasushi Nakamori, Yasuyuki Kuwagata
BACKGROUND: In November 2021, the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in South Africa and subsequently rapidly spread around the world. Despite the reduced severity of the omicron variants, many patients become severely ill after infection and undergo invasive mechanical ventilation, but there are few reports on their background and prognosis throughout all variant periods. This study aimed to evaluate risk factors affecting patients requiring invasive mechanical ventilation with each variant of COVID-19 pandemic in Japan from nonvariants to omicron variants...
February 20, 2024: BMC Infectious Diseases
#31
JOURNAL ARTICLE
Heleen Westland, Stefan Kuiper, Cheryl van den Bovenkamp, Etienne Blaas, Tiny Jaarsma
AIM: To explore self-care and needs and preferences towards tailored self-care support of patients with rheumatoid arthritis at the outpatient clinic. DESIGN: A sequential explanatory mixed method design. METHODS: The Self-Care of Chronic Illness Inventory questionnaire, two focus groups and six semi-structured interviews were conducted between November 2021 and April 2023. Questionnaires of 107 patients were descriptively analysed. Subsequently, 11 patients and 2 healthcare professionals participated in the focus groups and 6 patients in the interviews, which were thematically analysed...
February 17, 2024: Journal of Advanced Nursing
#32
Gi Eun Kim, Soubiya Ansari, Gabriala N Andrews, Sreethish Sasi, Jouhar Kolleri, Tasneem A Abdallah, Ibrahim F Hassan, Muna Al Maslamani
Purulent pericarditis is a rare but serious medical condition caused by an infection that spreads to the pericardial space surrounding the heart. Gram-positive organisms are the most common pathogens associated with purulent pericarditis. However, there has been a shift in recent years toward gram-negative bacteria. Klebsiella aerogenes is a rare pathogen that has never been linked to purulent pericarditis. In this report, we describe the case of a 40-year-old male patient with chronic bronchiectasis who, two months after suffering an injury, developed purulent pericarditis due to an uncommon organism, K...
January 2024: Curēus
#33
JOURNAL ARTICLE
Xunliang Li, Zhijuan Wang, Wenman Zhao, Rui Shi, Yuyu Zhu, Haifeng Pan, Deguang Wang
BACKGROUND: The objective of this study was to develop and validate a machine learning (ML) model for predict in-hospital mortality among critically ill patients with congestive heart failure (CHF) combined with chronic kidney disease (CKD). METHODS: After employing least absolute shrinkage and selection operator regression for feature selection, six distinct methodologies were employed in the construction of the model. The selection of the optimal model was based on the area under the curve (AUC)...
December 2024: Renal Failure
#34
JOURNAL ARTICLE
Michael Vanner, Alexander Tanner, Ali Chakera
We describe two patients, in their 70s, each presenting to the emergency department, with 6-week histories of progressively developing pruritic bullae. Both individuals had multiple comorbidities, including type 2 diabetes-for which they took linagliptin, chronic kidney disease, hypertension and prosthetic heart valves. Owing to systemic illness and endocarditis secondary to superadded bacterial infections, they both required intensive treatment and prolonged hospital admissions.Despite the beneficial effect of linagliptin on glycaemic control and its reported cardiovascular and renal safety profiles, we add our cases as evidence of the significant risk of developing bullous pemphigoid while taking this medication...
February 13, 2024: BMJ Case Reports
#35
Paras Thapa, Ganesh Bhattarai, Santosh Kumar Kharel, Pratiksha Kunwar, Sagar Bhandari, Shailaj Bhandari, Sushil Shilpakar, Bikash Thapa, Ajit Thapa, Mohan Raj Sharma
INTRODUCTION: The incidence of chronic subdural haematoma (cSDH) is relatively high among the elderly population. Other known risk factors for cSDH include male sex, dependency on anti-platelet or anticoagulant medication, and chronic alcoholism. Although, the standard mode of treatment for cSDH is surgery, embolization of the middle meningeal artery (MMA), either upfront or as an adjunct to surgical evacuation can be used for the treatment of cSDH. CASE PRESENTATION: The authors present a case of a 75-year-old female with prior history of posterior-lateral wall myocardial infarction (MI) eight years back presented to our centre with the chief complaints of a gradual onset of cough and headache for 2 months...
February 2024: Annals of Medicine and Surgery
#36
JOURNAL ARTICLE
Wasfa Farooq, Kulsum Kazi, Syed Ghazanfar Saleem, Saima Ali
OBJECTIVES: Emergency Departments (EDs) play a major role in managing acute and chronic illnesses, especially in low-to-middle-income countries like Pakistan, which lacks effective primary healthcare. This study reports the epidemiology and clinical characteristics of patients presenting over a two-year period at the Indus Hospital and Health Network (IHHN) adult ED in Karachi, Pakistan. METHODS: This is a retrospective observational study conducted through chart review of 264,859 patients, aged 16 years and above, who presented to the IHHN ED, Korangi Campus, from January 2019 to December 2020 after obtaining approval from IHHN IRB...
January 2024: Pakistan Journal of Medical Sciences Quarterly
#37
JOURNAL ARTICLE
Suchitra Rao, Rachel S Gross, Sindhu Mohandas, Cheryl R Stein, Abigail Case, Benard Dreyer, Nathan M Pajor, H Timothy Bunnell, David Warburton, Elizabeth Berg, Jonathan B Overdevest, Mark Gorelik, Joshua Milner, Sejal Saxena, Ravi Jhaveri, John C Wood, Kyung E Rhee, Rebecca Letts, Christine Maughan, Nick Guthe, Leah Castro-Baucom, Melissa S Stockwell
The coronavirus disease 2019 (COVID-19) pandemic has caused significant medical, social, and economic impacts globally, both in the short and long term. Although most individuals recover within a few days or weeks from an acute infection, some experience longer lasting effects. Data regarding the postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC) in children, or long COVID, are only just emerging in the literature. These symptoms and conditions may reflect persistent symptoms from acute infection (eg, cough, headaches, fatigue, and loss of taste and smell), new symptoms like dizziness, or exacerbation of underlying conditions...
February 7, 2024: Pediatrics
#38
JOURNAL ARTICLE
Esti Iturralde, Lisa Fazzolari, Natalie E Slama, Stacey E Alexeeff, Stacy A Sterling, Sameer Awsare, Maria T Koshy, Macy Shia
Objective: People with psychosis or bipolar disorder (severe and persistent mental illness [SPMI]) are at high risk for poor psychiatric and chronic illness outcomes, which could be ameliorated through improved health care quality. This study assessed whether a telehealth, collaborative care program managed by psychiatric clinical pharmacists (SPMI Population Care) was associated with improved health care quality for adults with SPMI in a large California health system. Methods: This retrospective cohort study used electronic health record data to compare 968 program enrollees at 6 demonstration sites (Population Care) to 8,339 contemporaneous patients with SPMI at 6 non-program sites (Usual Care)...
January 29, 2024: Journal of Clinical Psychiatry
#39
JOURNAL ARTICLE
Patricia A Ganz, Hanna Bandos, Tanja Španić, Sue Friedman, Volkmar Müller, Sherko Kuemmel, Suzette Delaloge, Etienne Brain, Masakazu Toi, Hideko Yamauchi, Eduardo-M de Dueñas, Anne Armstrong, Seock-Ah Im, Chuan-Gui Song, Hong Zheng, Tomasz Sarosiek, Priyanka Sharma, Cuizhi Geng, Peifen Fu, Kerstin Rhiem, Heike Frauchiger-Heuer, Pauline Wimberger, Daphné t'Kint de Roodenbeke, Ning Liao, Annabel Goodwin, Camille Chakiba-Brugère, Michael Friedlander, Keun Seok Lee, Sylvie Giacchetti, Toshimi Takano, Fernando Henao-Carrasco, Shamsuddin Virani, Frances Valdes-Albini, Susan M Domchek, Charles Bane, Edward C McCarron, Monica Mita, Giovanna Rossi, Priya Rastogi, Anitra Fielding, Richard D Gelber, Elsemieke D Scheepers, David Cameron, Judy Garber, Charles E Geyer, Andrew N J Tutt
PURPOSE: The OlympiA randomized phase III trial compared 1 year of olaparib (OL) or placebo (PL) as adjuvant therapy in patients with germline BRCA1/2 , high-risk human epidermal growth factor receptor 2-negative early breast cancer after completing (neo)adjuvant chemotherapy ([N]ACT), surgery, and radiotherapy. The patient-reported outcome primary hypothesis was that OL-treated patients may experience greater fatigue during treatment. METHODS: Data were collected before random assignment, and at 6, 12, 18, and 24 months...
February 1, 2024: Journal of Clinical Oncology
#40
JOURNAL ARTICLE
Fur-Hsing Wen, Holly G Prigerson, Tsung-Hui Hu, Chung-Chi Huang, Wen-Chi Chou, Li-Pang Chuang, Ming Chu Chiang, Siew Tzuh Tang
OBJECTIVES: To examine associations between family surrogates' bereavement outcomes and four previously determined quality of dying and death (QODD) latent classes (high, moderate, poor-to-uncertain, and worst). DESIGN: Prospective, longitudinal, observational study. SETTING: Medical ICUs at two academically affiliated medical centers in Taiwan. PATIENTS/PARTICIPANTS: Three hundred nine family surrogates responsible for decision-making for critically ill patients at high risk of death (Acute Physiology and Chronic Health Evaluation II scores > 20) from a disease...
February 1, 2024: Critical Care Medicine
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