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https://www.readbyqxmd.com/read/28428704/lead-poisoning-due-to-herbal-medications
#1
Shailja Chambial, Pankaj Bhardwaj, Abbas Ali Mahdi, Praveen Sharma
Lead ranks as one of the most serious environmental poisons all over the world amongst toxic heavy metals with no known biological function useful for the human body. A case of lead toxicity due to consumption of herbal medicine is being discussed. The case presented with gastrointestinal complaints and history of intake of herbal medicines for diabetes control for past 8 months. The analysis of the powdered herbal medicine procured from ayurveda practitioner was found to have high content of lead responsible for the lead toxicity...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28425705/facile-aqueous-phase-synthesis-of-ptau-bi2o3-hybrid-catalyst-for-efficient-electro-oxidation-of-ethanol
#2
Sumanta Sarkar, Rajkumar Jana, Hiranmayee Vadlamani, Swetha Ramani, Dundappa Mumbaraddi, Sebastian C Peter
In this work, we present a facile aqueous phase synthesis of a hybrid catalyst consists of PtAu alloy supported on Bi2O3 microspheres. Multistep reduction of HAuCl4 and K2PtCl4 salts on Bi2O3 and subsequent annealing leads to the formation of this hybrid catalyst. To the best of our knowledge, this is the first report of using Bi2O3 as a catalyst support in Fuel cell applications. The material was characterized by powder X-ray diffraction and various microscopic techniques. This composite showed remarkable activity as well as stability towards the electro-oxidation of ethanol in comparison to commercially available Pt/C...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28425396/development-and-single-laboratory-validation-of-a-liquid-chromatography-tandem-mass-spectrometry-method-for-quantitation-of-tetrodotoxin-in-mussels-and-oysters
#3
Andrew D Turner, Michael J Boundy, Monika Dhanji Rapkova
In recent years, evidence has grown for the presence of tetrodotoxin (TTX) in bivalve mollusks, leading to the potential for consumers of contaminated products to be affected by Tetrodotoxin Shellfish Poisoning (TSP). A single-laboratory validation was conducted for the hydrophilic interaction LC (HILIC) tandem MS (MS/MS) analysis of TTX in common mussels and Pacific oysters-the bivalve species that have been found to contain TTXs in the United Kingdom in recent years. The method consists of a single-step dispersive extraction in 1% acetic acid, followed by a carbon SPE cleanup step before dilution and instrumental analysis...
April 20, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28424960/selenium-for-the-mitigation-of-toxicity-induced-by-lead-in-chicken-testes-through-regulating-mrna-expressions-of-hsps-and-selenoproteins
#4
He Huang, Yan Wang, Yang An, Yaguang Tian, Shu Li, Xiaohua Teng
Lead (Pb) is a toxic element and environmental pollutant. Pb toxicity and antagonistic effect of selenium (Se) on Pb have been deeply studied in mammals. The testis is one of the target organs of Pb in birds. The aim of this study was to investigate the mitigating effect of Se on Pb toxicity in chicken testes by determining messenger RNA (mRNA) expressions of 5 heat shock proteins (HSPs) and 25 selenoproteins. Sixty male chickens (7-day-old) were randomly divided into the control group, the Se group, the Pb group, and the Pb + Se group, and were fed for 90 days...
April 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28418774/arsenic-in-the-groundwater-occurrence-toxicological-activities-and-remedies
#5
S K Jha, V K Mishra, T Damodaran, D K Sharma, Parveen Kumar
Arsenic (As) contamination in groundwater has become a geo-environmental as well as a toxicological problem across the globe affecting more than 100-million people in nearly 21 countries with its associated disease "arsenicosis." Arsenic poisoning may lead to fatal skin and internal cancers. In present review, an attempt has been made to generate awareness among the readers about various sources of occurrence of arsenic, its geochemistry and speciation, mobilization, metabolism, genotoxicity, and toxicological exposure on humans...
February 22, 2017: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/28414429/sub-lethal-lead-exposure-alters-movement-behavior-in-free-ranging-golden-eagles
#6
Frauke Ecke, Navinder J Singh, Jon M Arnemo, Anders Bignert, Björn Helander, Åsa M M Berglund, Hans Borg, Caroline Brojer, Karin Holm, Michael Lanzone, Tricia A Miller, Åke Nordström, Jannikke Raikkonen, Ilia Rodushkin, Erik Ågren, Birger Hörnfeldt
Lead poisoning of animals due to ingestion of fragments from lead-based ammunition in carcasses and offal of shot wildlife is acknowledged globally and raises great concerns about potential behavioral effects leading to increased mortality risks. Based on analyses of tracking data, we found that even sub-lethal lead concentrations in blood (25 ppb, wet weight), can likely negatively affect movement behavior (flight height and movement rate) of free-ranging scavenging Golden Eagles (Aquila chrysaetos). Lead levels in liver of recovered post-mortem analyzed eagles suggested that sub-lethal exposure increases the risk of mortality in eagles...
April 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28412021/prediction-and-validation-of-the-duration-of-hemodialysis-sessions-for-the-treatment-of-acute-ethylene-glycol-poisoning
#7
Ioan-Andrei Iliuta, Philippe Lachance, Marc Ghannoum, Yannick Bégin, Fabrice Mac-Way, Simon Desmeules, Sacha A De Serres, Anne-Sophie Julien, Pierre Douville, Mohsen Agharazii
The duration of hemodialysis (HD) sessions for the treatment of acute ethylene glycol poisoning is dependent on concentration, the operational parameters used during HD, and the presence and severity of metabolic acidosis. Ethylene glycol assays are not readily available, potentially leading to undue extension or premature termination of HD. We report a prediction model for the duration of high-efficiency HD sessions based retrospectively on a cohort study of 26 cases of acute ethylene glycol poisoning in 24 individuals treated by alcohol dehydrogenase competitive inhibitors, cofactors and HD...
April 12, 2017: Kidney International
https://www.readbyqxmd.com/read/28409973/transport-signatures-of-quasiparticle-poisoning-in-a-majorana-island
#8
S M Albrecht, E B Hansen, A P Higginbotham, F Kuemmeth, T S Jespersen, J Nygård, P Krogstrup, J Danon, K Flensberg, C M Marcus
We investigate effects of quasiparticle poisoning in a Majorana island with strong tunnel coupling to normal-metal leads. In addition to the main Coulomb blockade diamonds, "shadow" diamonds appear, shifted by 1e in gate voltage, consistent with transport through an excited (poisoned) state of the island. Comparison to a simple model yields an estimate of parity lifetime for the strongly coupled island (∼1  μs) and sets a bound for a weakly coupled island (>10  μs). Fluctuations in the gate-voltage spacing of Coulomb peaks at high field, reflecting Majorana hybridization, are enhanced by the reduced lever arm at strong coupling...
March 31, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28405068/hemodialysis-failure-secondary-to-hydroxocobalamin-exposure
#9
Kenneth Lim, Eliot Heher, David Steele, Andrew Z Fenves, John Kevin Tucker, Ravi Thadhani, Kenneth Christopher, Nina Tolkoff-Rubin
Hydroxocobalamin is a recently approved antidote for the treatment of cyanide poisoning. The case presented involves a young patient administered empiric hydroxocobalamin due to suspected cyanide overdose. Due to the development of acute kidney injury and severe metabolic derangement, emergent hemodialysis was initiated. Unfortunately, hemodialysis was confounded by a recurrent "blood leak" alarm. This unforeseen effect was secondary to interference from hydroxocobalamin. Hydroxocobalamin causes orange/red discoloration of bodily fluids and permeates the dialysate...
April 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28395679/lead-poisoning-in-shooting-range-workers-in-gauteng-province-south-africa-two-case-studies
#10
A Mathee, P De Jager, S Naidoo, N Naicker
BACKGROUND: Lead exposure constitutes a major public health concern globally. Relative to developed nations, lead exposure is understudied and poorly addressed in Africa, and there is a dearth of information available to inform lead poisoning prevention strategies, even in high-risk groups such as workers in shooting ranges who are potentially exposed to lead daily. METHODS: Two workers at a private shooting range in Gauteng, South Africa (SA), had blood lead levels and exposure histories taken...
March 29, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28389899/degradation-and-inactivation-of-shiga-toxins-by-nitrogen-gas-plasma
#11
Akikazu Sakudo, Yuichiro Imanishi
Shiga toxin (Stx)-producing Escherichia coli (STEC) leads to food poisoning by causing hemorrhagic colitis and hemolytic uremic syndrome. Some STEC produce Shiga toxin 1 (Stx1) and/or Shiga toxin 2 (Stx2), a relatively stable protein toxin, necessitating the development of an efficient inactivation method. Here we applied a nitrogen gas plasma apparatus to the inactivation of Stx. Samples of Stx1 and Stx2 were treated with a nitrogen gas plasma generated by a plasma device using a short high-voltage pulse applied by a static induction thyristor power supply at 1...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28379590/hepatotoxicity-of-paracetamol-and-related-fatalities
#12
R Tittarelli, M Pellegrini, M G Scarpellini, E Marinelli, V Bruti, N M di Luca, F P Busardò, S Zaami
Paracetamol, also known as acetaminophen, is the most commonly used antipyretic and pain reliever and since 1955 it is available over-the-counter as a single formulation or in combination with other substances and, as indicated by the World Health Organization, it can be used in all the three steps of pain intensity. Paracetamol toxicity is one of the most common causes of poisoning worldwide. While paracetamol is described as relatively nontoxic when administered in therapeutic doses, it is known to cause toxicity when taken in a single or repeated high dose, or after chronic ingestion...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28377603/hmgb1-tlr4-il23-il17a-axis-promotes-paraquat-induced-acute-lung-injury-by-mediating-neutrophil-infiltration-in-mice
#13
Bailing Yan, Feng Chen, Lijun Xu, Jihong Xing, Xuefu Wang
Paraquat is a poisoning herbicide that primarily targets lung, leading to severe acute lung injury characterized by extensive neutrophil infiltration. However, the mechanisms underlying the neutrophil infiltration is not clear. In this study, we demonstrated the significance of the signaling cascade from high-mobility group box 1 (HMGB1), to Toll-like receptor 4 (TLR4), interleukin-23 (IL-23), and lastly to IL-17A during the paraquat-induced neutrophil infiltration and the subsequent lung injury in mice. Paraquat challenge significantly elevated serum levels of IL-17A and IL-23, the percentage of IL-17A-producing γδT cells in the lung, and the level of HMGB1 in bronchoalveolar lavage fluid...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376842/pattern-of-acute-organophosphorus-poisoning-at-university-of-gondar-teaching-hospital-northwest-ethiopia
#14
Getnet Mequanint Adinew, Assefa Belay Asrie, Eshetie Melese Birru
BACKGROUND: Despite the apparent benefits of organophosphate compounds (OPCs) acute organophosphate (OP) pesticide poison is an increasing problem worldwide. In a country like Ethiopia, where agriculture is a major component of the economy, these compounds are readily available to the general public. There is paucity of evidence from Ethiopia showing the pattern of organophosphate poisoning (OPP) in healthcare facilities. The objective of this study was to evaluate retrospectively the pattern of acute OPP at the University of Gondar Teaching Hospital in northwest Ethiopia, during September 2010 through December 2014 was conducted...
April 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28376827/lead-exposure-at-firing-ranges-a-review
#15
REVIEW
Mark A S Laidlaw, Gabriel Filippelli, Howard Mielke, Brian Gulson, Andrew S Ball
BACKGROUND: Lead (Pb) is a toxic substance with well-known, multiple, long-term, adverse health outcomes. Shooting guns at firing ranges is an occupational necessity for security personnel, police officers, members of the military, and increasingly a recreational activity by the public. In the United States alone, an estimated 16,000-18,000 firing ranges exist. Discharge of Pb dust and gases is a consequence of shooting guns. METHODS: The objectives of this study are to review the literature on blood lead levels (BLLs) and potential adverse health effects associated with the shooting population...
April 4, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28376581/esperance-pica-study
#16
Kuroush A Ardeshirian, Donald A Howarth
BACKGROUND: Pica, the eating of non-foods, occurs particularly in children and pregnant women. It has been observed in communities all over the world. Pica is associated with iron deficiency and, in some environments, lead poisoning. This is the first time a study has assessed the prevalence of pica in Australia. METHODS: The study assessed the prevalence of pica in an Australian rural community, using a questionnaire given to parents of 223 children aged 2-10 years attending the five general practice surgeries in the shire...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28373142/aflatoxins-produced-by-aspergillus-parasiticus-present-in-the-diet-of-quails-increase-the-activities-of-cholinesterase-and-adenosine-deaminase
#17
Aleksandro Schafer da Silva, Janio M Santurio, Lenilson F Roza, Nathieli B Bottari, Gabriela M Galli, Vera M Morsch, Maria Rosa C Schetinger, Matheus D Baldissera, Lenita M Stefani, Willian M Radavelli, Thainã Tomasi, Marcel M Boiago
The aim of this study was to evaluate the effects of aflatoxins on cholinesterases (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and adenosine deaminase (ADA) activities in quails. For this, twenty male quails were randomly distributed into two groups (n = 10 each): the group A was composed by quails that received feed without aflatoxin (the control group); while the group B was composed by quails that received feed contaminated with 200 ppm/kg of feed of aflatoxin. On day 20, the animals were euthanized to measure the activities of AChE (total blood and brain), BChE (serum) and ADA (serum, liver, and brain), as well as for histopathological analyses (liver and intestine)...
March 31, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28372541/nephrotoxicity-induced-proteinuria-increases-biomarker-diagnostic-thresholds-in-acute-kidney-injury
#18
Fahim Mohamed, Nicholas A Buckley, John W Pickering, Klintean Wunnapuk, Sandamali Dissanayake, Umesh Chathuranga, Indika Gawarammana, Shaluka Jayamanne, Zoltan H Endre
BACKGROUND: Paraquat ingestion is frequently fatal. While biomarkers of kidney damage increase during paraquat-induced acute kidney injury (AKI), significant concurrent proteinuria may alter diagnostic thresholds for diagnosis and prognosis to an unknown extent. This study evaluated the effect of albuminuria on biomarker cutoffs for diagnosis and outcome prediction. METHODS: This was a multi-centre prospective clinical study of patients following acute paraquat self-poisoning in 5 Sri Lankan hospitals...
April 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28366404/sulfated-diesters-of-okadaic-acid-and-dtx-1-self-protective-precursors-of-diarrhetic-shellfish-poisoning-dsp-toxins
#19
Tingmo Hu, Patricia LeBlanc, Ian W Burton, John A Walter, Pearse McCarron, Jeremy E Melanson, Wendy K Strangman, Jeffrey L C Wright
Many toxic secondary metabolites used for defense are also toxic to the producing organism. One important way to circumvent toxicity is to store the toxin as an inactive precursor. Several sulfated diesters of the diarrhetic shellfish poisoning (DSP) toxin okadaic acid have been reported from cultures of various dinoflagellate species belonging to the genus Prorocentrum. It has been proposed that these sulfated diesters are a means of toxin storage within the dinoflagellate cell, and that a putative enzyme mediated two-step hydrolysis of sulfated diesters such as DTX-4 and DTX-5 initially leads to the formation of diol esters and ultimately to the release of free okadaic acid...
March 2017: Harmful Algae
https://www.readbyqxmd.com/read/28364786/dandelion-enriched-diet-of-mothers-alleviates-lead-induced-damages-in-liver-of-newborn-rats
#20
M Gargouri, C Magné, I Ben Amara, H Ben Saad, A El Feki
Lead (Pb) is a highly toxic metal present in the environment. It causes disturbances of several functions, including hematologic, renal, reproductive and nervous ones. Preventive or curative use of medicinal plants against these disorders may be a promising and safe therapeutic strategy. This study evaluated the hepatic toxic effects of prenatal exposure to lead in rats and the possible protective effect of dandelion (Taraxacum officinale) added to the diet. Female rats were given a normal diet (control) or a diet enriched with dandelion (treated)...
February 28, 2017: Cellular and Molecular Biology
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