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https://www.readbyqxmd.com/read/28636419/poison-or-prevention-understanding-the-linkages-between-vaccine-negative-individuals-knowledge-deficiency-motivations-and-active-communication-behaviors
#1
Arunima Krishna
The last few decades have seen growing concerns among parents regarding the safety of childhood vaccines, arguably leading to the rise of the anti-vaccine movement. This study is an effort to understand situational and cross-situational factors that influence individuals' negative attitudes toward vaccines, referred to as vaccine negativity. In doing so, this study elucidated how situational and cross-situational factors influence vaccine negativity. Specifically, this study tested how knowledge deficiency, or acceptance of scientifically inaccurate data about vaccines, and institutional trust influenced negative attitudes toward vaccines...
June 21, 2017: Health Communication
https://www.readbyqxmd.com/read/28635329/lead-induces-siberian-tiger-fibroblast-apoptosis-by-interfering-with-intracellular-homeostasis
#2
Zheng Liu, Hui Wang, Wenxiu Zhang, Ziao Yuan, Hongyi Yuan, Xueting Liu, Minghai Zhang, Xuesong Guo, Weijun Guan
Lead (Pb(2+)) is a poisonous heavy metal that causes many pathophysiological effects in living systems. Its toxicological effects are well known as it causes apoptosis of several cell types and tissues. This study aimed to determine the criteria required for early diagnosis of Pb(2+) poisoning in the Siberian tiger using a tiger population in China, to identify a safety Pb(2+) concentration threshold, and to provide suggestions for preventing Pb(2+) poisoning in Siberian tigers. We investigated the apoptotic effects of Pb(2+) (0, 32, 64, and 125 μM) for 12-48 h on Siberian tiger fibroblasts in vitro...
June 21, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28630774/lead-poisoning-can-be-easily-misdiagnosed-as-acute-porphyria-and-nonspecific-abdominal-pain
#3
Ming-Ta Tsai, Shi-Yu Huang, Shih-Yu Cheng
Lead poisoning (LP) is less commonly encountered in emergency departments (ED). However, lead exposure still occurs, and new sources of poisoning have emerged. LP often goes unrecognized due to a low index of suspicion and nonspecific symptoms. We present a case of a 48-year-old man who had recurring abdominal pain with anemia that was misdiagnosed. His condition was initially diagnosed as nonspecific abdominal pain and acute porphyria. Acute porphyria-like symptoms with a positive urine porphyrin test result led to the misdiagnosis; testing for heme precursors in urine is the key to the differential diagnosis between LP and acute porphyria...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/28629212/a-study-of-the-modulating-action-of-quercetin-on-biochemical-and-histological-alterations-induced-by-lead-exposure-in-the-liver-and-kidney-of-rats
#4
Azza Sedky, Hany Elsawy
Lead is a highly toxic metal and a very potent poison. Lead poisoning is a serious condition but can be treated. Quercetin is a flavonoid with many beneficial uses. The aim of the present study was to investigate the possible modulating action of quercetin as a model of an antioxidant against the toxic effects of lead acetate on liver and kidneys of rats. Rats were randomly divided into four groups: (i) saline group (control); (ii) lead group received i.p. lead acetate (20 mg/kg b.w.); (iii) quercetin group received i...
June 30, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28621655/trends-in-the-leading-causes-of-injury-mortality-australia-canada-and-the-united-states-2000-2014
#5
Karin Mack, Angela Clapperton, Alison Macpherson, David Sleet, Donovan Newton, James Murdoch, J Morag Mackay, Janneke Berecki-Gisolf, Natalie Wilkins, Angela Marr, Michael Ballesteros, Roderick McClure
OBJECTIVES: The aim of this study was to highlight the differences in injury rates between populations through a descriptive epidemiological study of population-level trends in injury mortality for the high-income countries of Australia, Canada and the United States. METHODS: Mortality data were available for the US from 2000 to 2014, and for Canada and Australia from 2000 to 2012. Injury causes were defined using the International Classification of Diseases, Tenth Revision external cause codes, and were grouped into major causes...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28621023/pediatric-liver-transplantation-for-fulminant-hepatic-failure-secondary-to-intentional-iron-overdose
#6
Joanne Lai, Jaime Chu, Ronen Arnon
Acute iron poisoning may lead to life-threatening hepatotoxicity. We present the cases of two pediatric patients with hepatotoxicity following intentional iron ingestion that progressed rapidly to fulminant hepatic failure despite treatment with deferoxamine. Liver transplantation was lifesaving in both patients. These cases emphasize the need for a high index of suspicion for iron ingestion, close monitoring for liver toxicity, and timely consideration for liver transplantation.
June 15, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28620777/concentrations-of-lead-and-other-elements-in-the-liver-of-the-white-tailed-eagle-haliaeetus-albicilla-a-european-flagship-species-wintering-in-eastern-poland
#7
Ignacy Kitowski, Dariusz Jakubas, Dariusz Wiącek, Agnieszka Sujak
As a top predator, the white-tailed eagle (Haliaeetus albicilla) may serve as a good indicator species, providing information about the bioavailability of contaminants and their transfer within the food chain. In this study, we aimed to determine the common sources of origin of 17 metals and other elements in the liver of white-tailed eagles, and to compare the variations in their hepatic concentrations by age (adults vs immatures) and sex (males vs females) in groups of white-tailed eagles wintering in Eastern Poland...
June 15, 2017: Ambio
https://www.readbyqxmd.com/read/28620106/coarse-basophilic-stippling-in-lead-poisoning
#8
Nelson C N Chan, K P Chan
No abstract text is available yet for this article.
June 15, 2017: Blood
https://www.readbyqxmd.com/read/28617190/experimental-and-theoretical-studies-of-cadmium-ions-absorption-by-a-new-reduced-recombinant-defensin
#9
Karim Mahnam, Samira Foruzandeh, Neda Mirakhorli, Behnaz Saffar
Heavy metal pollutants such as Cd, Hg, Pb, As and Se are considered as both a global problem and a growing threat to the humanity. Being strongly poisonous to the metal-sensitive enzymes and leading to the growth inhibition and death of organisms, these metals have a toxic impact on the plants and animals. Inducing the metal-binding cysteine-rich peptides such as metallothioneins, phytochelatins, and defensins, higher organisms like plants and animals usually react to the heavy metal stress. In this study, a recombinant defensin protein was expressed in bean and its ability in the cadmium absorption was determined...
June 15, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28609563/bayesian-forecasting-tool-to-predict-the-need-for-antidote-in-acute-acetaminophen-overdose
#10
Julie Desrochers, Jessica Wojciechowski, Wendy Klein-Schwartz, Jogarao V S Gobburu, Mathangi Gopalakrishnan
STUDY OBJECTIVE: Acetaminophen (APAP) overdose is the leading cause of acute liver injury in the United States. Patients with elevated plasma acetaminophen concentrations (PAC) require hepatoprotective treatment with N-acetylcysteine (NAC). These patients have been primarily risk-stratified using the Rumack-Matthew nomogram. Previous studies of acute APAP overdoses found that the nomogram failed to accurately predict the need for the antidote. The objectives of this study were to develop a population pharmacokinetic (PK) model for APAP following acute overdose and evaluate the utility of population PK model-based Bayesian forecasting in NAC administration decisions...
June 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28604801/high-blood-levels-of-lead-in-children-aged-6-36-months-in-kathmandu-valley-nepal-a-cross-sectional-study-of-associated-factors
#11
Meghnath Dhimal, Khem Bahadur Karki, Krishna Kumar Aryal, Bimala Dhimal, Hari Datt Joshi, Sajan Puri, Achyut Raj Pandey, Purushotam Dhakal, Arun Kumar Sharma, Ganendra Bhakta Raya, Imran Ansari, David A Groneberg, Ruth Müller, Ulrich Kuch
Young children are at greatest risk of exposure to lead and its effects. Although lead is one of the most widely used elements with known health hazard, there is little data on the blood lead level (BLL) of children in the Kathmandu Valley. Thus, this study aimed to assess factors associated with high BLL in children who were 6-36 months of age and resided in the Kathmandu Valley. In this hospital-based cross-sectional study 6-36 month-old children visiting the Paediatrics Outpatient Department of Tribhuvan University Teaching Hospital, Patan Hospital, and Siddhi Memorial Hospital were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28602975/the-small-molecule-inhibitor-yk-4-279-disrupts-mitotic-progression-of-neuroblastoma-cells-overcomes-drug-resistance-and-synergizes-with-inhibitors-of-mitosis
#12
Madhu Kollareddy, Alice Sherrard, Ji Hyun Park, Marianna Szemes, Kelli Gallacher, Zsombor Melegh, Sebastian Oltean, Martin Michaelis, Jindrich Cinatl, Abderrahmane Kaidi, Karim Malik
Neuroblastoma is a biologically and clinically heterogeneous pediatric malignancy that includes a high-risk subset for which new therapeutic agents are urgently required. As well as MYCN amplification, activating point mutations of ALK and NRAS are associated with high-risk and relapsing neuroblastoma. As both ALK and RAS signal through the MEK/ERK pathway, we sought to evaluate two previously reported inhibitors of ETS-related transcription factors, which are transcriptional mediators of the Ras-MEK/ERK pathway in other cancers...
June 7, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28601018/geospatial-evaluation-of-lead-bioaccessibility-and-distribution-for-site-specific-prediction-of-threshold-limits
#13
Jennifer A Bower, Sydney Lister, Garrett Hazebrouck, Nicolas Perdrial
Recent work identified the need for site-specific Pb bioaccessibility evaluation and scaled contaminant modeling. Pb heterogeneity has made bioaccessibility characterization difficult, and complicated distribution models. Using field testing, bioaccessibility measurement, Integrated Exposure Uptake and Biokinetic (IEUBK) modeling, and geospatial techniques, we propose a framework for conducting applied risk-based, multiscale assessment. This framework was tested and implemented in Burlington, VT, an area of old housing stock and high Pb burden (up to 15 000 mg kg(-1)) derived primarily from paint...
June 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28600415/schmallenberg-virus-infection-confirmed-in-scotland
#14
(no author information available yet)
Schmallenberg virus infection in malformed lambsFood chain issues after lead poisoning incidentSuspected ragwort poisoning in heifersEwe abortions due to Salmonella enterica serovar UrbanaCoxiella burnetii detected in aborted lambsThese are among matters discussed in the disease surveillance report for February 2017 from SAC Consulting: Veterinary Services (SAC C VS).
June 10, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28595923/microstructural-and-ultrastructural-changes-in-the-muscle-cells-of-the-oriental-armyworm-mythimna-separata-walker-lepidoptera-noctuidae-on-treatment-with-wilforine
#15
Shujie Ma, Lin Liu, Zhiqing Ma, Xing Zhang
This study investigated the mode of action of wilforine, an alkaloid with insecticidal properties, extracted from Tripterygium wilfordii Hook f., on the microstructure and ultrastructure of the muscle cells of larvae and adults of the oriental armyworm Mythimna separata Walker. The bioassay results showed that wilforine had oral toxicity against both M. separata larvae (LC50=63μg/mL) and adults (LC50=36μg/mL). The typical toxicity sign was paralysis leading to death. Both light and electron microscope observations revealed that damage to the muscle cells increased with poisoning time in larvae and adults treated with the LC80 dose of wilforine...
June 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28591253/acute-kidney-injury-complicating-bee-stings-a-review
#16
Geraldo Bezerra da Silva, Adolfo Gomes Vasconcelos, Amanda Maria Timbó Rocha, Vanessa Ribeiro de Vasconcelos, João de Barros, Julye Sampaio Fujishima, Nathália Barros Ferreira, Elvino José Guardão Barros, Elizabeth De Francesco Daher
Bee stings can cause severe reactions and have caused many victims in the last years. Allergic reactions can be triggered by a single sting and the greater the number of stings, the worse the prognosis. The poisoning effects can be systemic and can eventually cause death. The poison components are melitin, apamin, peptide 401, phospholipase A2, hyaluronidase, histamine, dopamine, and norepinephrine, with melitin being the main lethal component. Acute kidney injury (AKI) can be observed in patients suffering from bee stings and this is due to multiple factors, such as intravascular hemolysis, rhabdomyolysis, hypotension and direct toxicity of the venom components to the renal tubules...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28577234/antagonistic-effect-of-laver-pyropia-yezonensis-and-p-haitanensis-on-subchronic-lead-poisoning-in-rats
#17
Yingying Guo, Xiaohui Gu, Yanhua Jiang, Wenjia Zhu, Lin Yao, Zhantao Liu, Hua Gao, Lianzhu Wang
Lead, one of the most harmful heavy metals, can cause various hazardous effects on living organisms. This study was undertaken to evaluate the antagonistic and protective effects of two economically important laver species, Pyropia yezoensis and P. haitanensis, against subchronic lead poisoning in rats by a 30-day feeding test. Sixty-four healthy Wistar rats were randomly divided into eight groups with eight rats (4♂ + 4♀) per group, among which, one group was served as the control, the others were respectively treated with lead acetate (5 mg/kg b w), and a combination of lead acetate and P...
June 3, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28573226/evaluation-of-the-chelating-effect-of-methanolic-extract-of-coriandrum-sativum-and-its-fractions-on-wistar-rats-poisoned-with-lead-acetate
#18
Miguel Ángel Téllez-López, Gabriela Mora-Tovar, Iromi Marlen Ceniceros-Méndez, Concepción García-Lujan, Cristo Omar Puente-Valenzuela, María Del Carmen Vega-Menchaca, Luis Benjamín Serrano-Gallardo, Rubén García Garza, Javier Morán-Martínez
BACKGROUND: The rate of lead poisoning has decreased in recent years due to increased health control in industries that use this metal. However, it is still a public health problem worldwide. The use of various plants with chelating properties has been a topic of research today. In traditional medicine, it is said that Coriandrum sativum has chelating properties, but there is no scientific evidence to support this fact. The purpose of this research is to evaluate the chelating effect of methanol extract of coriander and its fractions on Wistar rats intoxicated with lead...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28570504/amanita-phalloides-mushroom-poisonings-northern-california-december-2016
#19
Kathy T Vo, Martha E Montgomery, S Todd Mitchell, Pieter H Scheerlinck, Daniel K Colby, Kathryn H Meier, Susan Kim-Katz, Ilene B Anderson, Steven R Offerman, Kent R Olson, Craig G Smollin
Amanita phalloides, colloquially known as the "death cap," belongs to the Phalloideae section of the Amanita family of mushrooms and is responsible for most deaths following ingestion of foraged mushrooms worldwide (1). On November 28, 2016, members of the Bay Area Mycological Society notified personnel at the California Poison Control System (CPCS) of an unusually large A. phalloides bloom in the greater San Francisco Bay Area, coincident with the abundant rainfall and recent warm weather. Five days later, CPCS received notification of the first human A...
June 2, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28557759/assessing-child-lead-poisoning-case-ascertainment-in-the-us-1999-2010
#20
Eric M Roberts, Daniel Madrigal, Jhaqueline Valle, Galatea King, Linda Kite
OBJECTIVES: To compare prevalence estimates for blood lead level ≥10.0 μg/dL (elevated blood lead level [EBLL]) with numbers reported to the Centers for Disease Control and Prevention (CDC) for children 12 months to 5 years of age from 1999 to 2010 on a state-by-state basis. METHODS: State-specific prevalence estimates were generated based on the continuous NHANES according to newly available statistical protocols. Counts of case reports were based on the 39 states (including the District of Columbia) reporting to the CDC Childhood Lead Poisoning Prevention Program during the study period...
May 2017: Pediatrics
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