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High sensitivity CRP

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https://www.readbyqxmd.com/read/28920169/diagnostic-value-of-strem-1-il-8-pct-and-crp-in-febrile-neutropenia-after-autologous-stem-cell-transplantation
#1
C S Michel, D Teschner, E M Wagner, M Theobald, Markus P Radsak
Infections and infectious complications are the major cause of morbidity and mortality in febrile neutropenic patients after autologous stem cell transplantation. Laboratory biomarkers are helpful for early identification of critically ill patients and optimal therapy management. Several studies in adult non-neutropenic patients proposed sTREM-1 as a superior biomarker for identification of septic patients as well as a predictor for survival in these patients compared with procalcitonin (PCT), C-reactive protein (CRP), or interleukin-8 (IL-8)...
September 17, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28918492/decreased-plasma-neuregulin-4-concentration-is-associated-with-increased-high-sensitivity-c-reactive-protein-in-newly-diagnosed-type-2-diabetes-mellitus-patients-a-cross-sectional-study
#2
Pi-Jun Yan, Yong Xu, Qin Wan, Jian Feng, Hua Li, Chen-Lin Gao, Jun Yang, Hai-Hua Zhong, Zhi-Hong Zhang
AIMS: Inflammation has been reported to be involved in the pathogenesis of atherosclerosis. This principal objective of this study was to investigate if the secretion of neuregulin 4 (Nrg4), a soluble protein associated with metabolic syndrome and subclinical cardiovascular disease, is correlated with the inflammation marker high-sensitivity C-reactive protein (hs-CRP) in patients with newly diagnosed type 2 diabetes mellitus (nT2DM). METHODS: A study group of 311 nT2DM patients was divided into three subgroups based on hs-CRP tertiles...
September 16, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28918433/procalcitonin-and-c-reactive-protein-as-early-markers-of-postoperative-intra-abdominal-infection-in-patients-operated-on-colorectal-cancer
#3
E Domínguez-Comesaña, S M Estevez-Fernández, V López-Gómez, J Ballinas-Miranda, R Domínguez-Fernández
PURPOSE: The aim of this study was to evaluate the accuracy of serum procalcitonin (PCT) and C-reactive protein (CRP) for early diagnosis of postoperative intra-abdominal infections (PIAI) after elective surgery for colorectal cancer. METHODS: Prospective observational study including patients operated on for colorectal cancer between January and December of 2015 was performed. Serum PCT and CRP levels were measured before surgery and daily until postoperative day 3...
September 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28917588/association-between-fsp-cvhi-inflammatory-cytokines-and-the-incidence-of-primary-stroke
#4
Xiao-Yun Huang, Wen-Jin Fu, Zhi-Chang Chen, Zhi-Zhong Mei, Ying-Li Yu, Hao-Wei Fang, Yi-Hong Huang, Han Lin, Jian-Jun Chen, Ming-Xia Wang, Shao-Bing Guan, Wan-Xian Lu, Xiao-Ling Chen
This case-control study was designed to establish a new risk-prediction model for primary stroke using Framingham stroke profile (FSP), cerebral vascular hemodynamic indexes (CVHI) and plasma inflammatory cytokines including hs-CRP, IL-6, TNF-α and Lp-PLA2. A total of 101 primary stroke patients admitted to Dongguan Houjie Hospital between August 2014 and June 2015 were assigned into the case group, and 156 age- and gender-matched healthy subjects from the Houjie Community were allocated into the control group...
September 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28911155/differential-associations-of-inflammatory-markers-with-insulin-sensitivity-and-secretion-the-prospective-metsim-study
#5
Maria Fizelova, Raimo Jauhiainen, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Johanna Kuusisto, Markku Laakso, Alena Stancáková
Context: Low-grade inflammation is involved in the development of type 2 diabetes and cardiovascular disease (CVD); however, prospective studies evaluating inflammatory markers as predictors of changes in insulin secretion and insulin sensitivity are lacking. Objective: We investigated the associations of glycoprotein acetyls (GlycA), interleukin-1 receptor antagonist (IL-1RA), and high-sensitivity C-reactive protein (hs-CRP) with insulin secretion, insulin sensitivity, incident type 2 diabetes, hypertension, CVD events, and total mortality in the prospective Metabolic Syndrome in Men (METSIM) study...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28904075/association-between-living-in-food-deserts-and-cardiovascular-risk
#6
Heval M Kelli, Muhammad Hammadah, Hina Ahmed, Yi-An Ko, Matthew Topel, Ayman Samman-Tahhan, Mossab Awad, Keyur Patel, Kareem Mohammed, Laurence S Sperling, Priscilla Pemu, Viola Vaccarino, Tene Lewis, Herman Taylor, Greg Martin, Gary H Gibbons, Arshed A Quyyumi
BACKGROUND: Food deserts (FD), neighborhoods defined as low-income areas with low access to healthy food, are a public health concern. We evaluated the impact of living in FD on cardiovascular risk factors and subclinical cardiovascular disease (CVD) with the hypothesis that people living in FD will have an unfavorable CVD risk profile. We further assessed whether the impact of FD on these measures is driven by area income, individual household income, or area access to healthy food. METHODS AND RESULTS: We studied 1421 subjects residing in the Atlanta metropolitan area who participated in the META-Health study (Morehouse and Emory Team up to Eliminate Health Disparities; n=712) and the Predictive Health study (n=709)...
September 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28904072/validation-of-a-novel-assay-to-distinguish-bacterial-and-viral-infections
#7
Isaac Srugo, Adi Klein, Michal Stein, Orit Golan-Shany, Nogah Kerem, Irina Chistyakov, Jacob Genizi, Oded Glazer, Liat Yaniv, Alina German, Dan Miron, Yael Shachor-Meyouhas, Ellen Bamberger, Kfir Oved, Tanya M Gottlieb, Roy Navon, Meital Paz, Liat Etshtein, Olga Boico, Gali Kronenfeld, Eran Eden, Robert Cohen, Helène Chappuy, François Angoulvant, Laurence Lacroix, Alain Gervaix
BACKGROUND: Reliably distinguishing bacterial from viral infections is often challenging, leading to antibiotic misuse. A novel assay that integrates measurements of blood-borne host-proteins (tumor necrosis factor-related apoptosis-inducing ligand, interferon γ-induced protein-10, and C-reactive protein [CRP]) was developed to assist in differentiation between bacterial and viral disease. METHODS: We performed double-blind, multicenter assay evaluation using serum remnants collected at 5 pediatric emergency departments and 2 wards from children ≥3 months to ≤18 years without (n = 68) and with (n = 529) suspicion of acute infection...
September 13, 2017: Pediatrics
https://www.readbyqxmd.com/read/28903520/hepatic-renal-hematologic-and-inflammatory-markers-in-hiv-infected-children-on-long-term-suppressive-antiretroviral-therapy
#8
Ann J Melvin, Meredith Warshaw, Alexandra Compagnucci, Yacine Saidi, Linda Harrison, Anna Turkova, Gareth Tudor-Williams
Background: Data on long-term toxicity of antiretroviral therapy (ART) in HIV-infected children are sparse. PENPACT-1 was an open-label trial in which HIV-infected children were assigned randomly to receive protease inhibitor (PI)- or nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based ART. Methods: We examined changes in clinical, immunologic, and inflammatory markers from baseline to year 4 in the subset of children in the PENPACT-1 study who experienced viral suppression between week 24 and year 4 of ART...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28902946/the-association-between-low-grade-systemic-inflammation-and-skin-diseases-a-cross-sectional-survey-in-the-northern-finland-birth-cohort-1966
#9
Suvi-Päivikki Sinikumpu, Laura Huilaja, Juha Auvinen, Jari Jokelainen, Katri Puukka, Aimo Ruokonen, Markku Timonen, Kaisa Tasanen
Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population...
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28901315/serum-expression-level-of-squamous-cell-carcinoma-antigen-highly-sensitive-c-reactive-protein-and-ca-125-as-potential-biomarkers-for-recurrence-of-cervical-cancer
#10
Suyang Guo, Bo Yang, Hongli Liu, Yuzhi Li, Shengze Li, Ling Ma, Jian Liu, Wei Guo
OBJECTIVE: The aim of this study was to evaluate the serum expression levels of squamous cell carcinoma antigen (SCC-Ag), highly sensitive C-reactive protein (hs-CRP), and CA-125 as potential serum biomarkers for recurrence of cervical cancer. METHODS: Eighty-six cervical cancer patients who received radical treatment were retrospectively included in this study from February 2011 to January 2014. Of the included 86 cases, 23 were recurred within the 36 months (recurrence group [RG]) and other 63 patients did not (non-RG [NRG])...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28899715/the-relationship-between-25-hydroxyvitamin-d-concentration-and-liver-enzymes-in-overweight-or-obese-adults-cross-sectional-and-interventional-outcomes
#11
Negar Naderpoor, Aya Mousa, Maximilian de Courten, Robert Scragg, Barbora de Courten
Vitamin D deficiency is prevalent in individuals with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis. However, there is limited and inconsistent data on the effect of vitamin D supplementation on liver function. Hepatic enzymes have been used as surrogate markers for NAFLD and have been associated with metabolic syndrome. We examined the relationships between 25-hydroxyvitamin D (25(OH)D) and γ-glutamyl transferase (GGT), alanine aminotransferase (ALT), alkaline phosphatase (ALP) in 120 drug-naïve individuals with no history of liver disease...
September 9, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28895791/general-lack-of-correlations-between-age-and-signs-of-the-metabolic-syndrome-in-subjects-with-non-diabetic-fasting-glucose-values
#12
Harry G Preuss, Nate Mrvichin, Dallas Clouatre, Debasis Bagchi, Jeffrey M Preuss, Nicholas V Perricone, Anand Swaroop, Gilbert R Kaats
BACKGROUND: Insulin resistance and advancing age are well-recognized risk factors for metabolic syndrome. Recent reports indicate that fasting glucose levels in non-diabetic patients correlate appropriately with the development of certain elements in metabolic syndrome, which suggest a cause-effect relationship with insulin resistance. OBJECTIVE: The present investigation assessed whether a significant association exists between chronological age and various elements of metabolic syndrome in this same group of subjects possessing non-diabetic fasting glucose levels...
September 12, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28891932/inadequate-vitamin-c-status-in-prediabetes-and-type-2-diabetes-mellitus-associations-with-glycaemic-control-obesity-and-smoking
#13
Renée Wilson, Jinny Willis, Richard Gearry, Paula Skidmore, Elizabeth Fleming, Chris Frampton, Anitra Carr
Vitamin C (ascorbate) is an essential micronutrient in humans, being required for a number of important biological functions via acting as an enzymatic cofactor and reducing agent. There is some evidence to suggest that people with type 2 diabetes mellitus (T2DM) have lower plasma vitamin C concentrations compared to those with normal glucose tolerance (NGT). The aim of this study was to investigate plasma vitamin C concentrations across the glycaemic spectrum and to explore correlations with indices of metabolic health...
September 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28886992/study-on-the-effect-of-irbesartan-on-atrial-fibrillation-recurrence-in-kumamoto-atrial-fibrillation-suppression-trial-silk-study
#14
Hiroshige Yamabe, Koichi Kaikita, Toshiyuki Matsumura, Atsushi Iwasa, Junjiro Koyama, Takashi Uemura, Yasuhiro Morikami, Ryusuke Tsunoda, Kenji Morihisa, Kazuteru Fujimoto, Ichiro Kajiwara, Kunihiko Matsui, Kenichi Tsujita, Hisao Ogawa
BACKGROUND: Experimental studies suggest that angiotensin II-receptor blockers can influence atrial remodeling and may prevent atrial fibrillation (AF). Therefore, we hypothesized that irbesartan may prevent the recurrence of AF following either catheter ablation or electrical cardioversion of AF. METHODS: Study on the Effect of Irbesartan on Atrial Fibrillation Recurrence in Kumamoto (SILK study) is a prospective, multicenter, randomized, and open-label comparative evaluation of the effects of irbesartan and amlodipine on AF recurrence in hypertensive patients with AF who are scheduled to undergo catheter ablation or electrical cardioversion of AF...
September 5, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28886903/the-relationships-of-current-suicidal-ideation-with-inflammatory-markers-and-heart-rate-variability-in-unmedicated-patients-with-major-depressive-disorder
#15
Chuan-Chia Chang, Nian-Sheng Tzeng, Yu-Chen Kao, Chin-Bin Yeh, Hsin-An Chang
Studies investigating inflammatory status and autonomic functioning simultaneously in depressed patients with current suicidal ideation (SI) are lacking. We recruited 58 unmedicated depressed patients with current SI but without lifetime history of suicidal behavior, as well as 61 equally depressed patients without lifetime history of SI or suicidal behavior. We measured serum cortisol, high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and autonomic functioning evaluated by frequency-domain measures of heart rate variability (HRV)...
August 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28886725/is-it-a-supplementary-benefit-to-use-anti-inflammatory-agents-in-the-treatment-of-type-2-diabetes
#16
Nzogang K Patrice, Donkeng J Martial, Telefo P Bruno
OBJECTIVE: The aim of this study was to investigate an independent correlation between high sensitivity C-reactive protein (hs-CRP) and glycated haemoglobin (HbA1c) on one side and between hs-CRP and arterial pressure in well glucose controlled type 2 diabetics on the other side. RESULTS: The mean of HbA1c was 6.37% in this study and 70.10% of participants had an HbA1c less than 7%. A positive correlation between hs-CRP and HbA1c was found in the current study (r = 0...
September 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28885233/diagnostic-value-of-pct-and-crp-for-detecting-serious-bacterial-infections-in-patients-with-fever-of-unknown-origin-a-systematic-review-and-meta-analysis
#17
Lan Hu, Qiuping Shi, Miao Shi, Ruixia Liu, Chao Wang
BACKGROUND: It is vital to recognize the cause of an infection to enable earlier treatment. Studies have shown that procalcitonin (PCT) and C-reactive protein (CRP) have very high sensitivity and specificity for diagnosing serious bacterial infections (SBIs), with PCT performing better than CRP. METHODS: Multiple databases were searched for relevant studies, and full-text articles involving diagnosis with PCT and CRP were reviewed. All meta-analyses were conducted with Review Manager 5...
September 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28885052/migraine-and-vascular-disease-biomarkers-a-population-based-case-control-study
#18
Gretchen E Tietjen, Jagdish Khubchandani, Nabeel Herial, Inge H Palm-Meinders, Hille Koppen, Gisela M Terwindt, Mark A van Buchem, Lenore J Launer, Michel D Ferrari, Mark C Kruit
Background The underpinnings of the migraine-stroke association remain uncertain, but endothelial activation is a potential mechanism. We evaluated the association of migraine and vascular disease biomarkers in a community-based population. Methods Participants (300 women, 117 men) were recruited as a part of the Dutch CAMERA 1 (Cerebral Abnormalities in Migraine, an Epidemiologic Risk Analysis) study. Participants were aged 30-60 (mean 48) years, 155 migraine had with aura (MA), 128 migraine without aura (MO), and 134 were controls with no severe headaches...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28882065/annals-express-serum-high-sensitive-c-reactive-protein-is-associated-with-dietary-intakes-in-diabetic-patients-with-and-without-hypertension-a-cross-sectional-study
#19
Mohammad Bagherniya, Sayyed Saeid Khayyatzadeh, Ali Reza Heidari-Bakavoli, Gordon Ferns, Mahmoud Ebrahimi, Mohammad Safarian, Mohsen Nematy, Majid Ghayour-Mobarhan
BACKGROUND: Serum high sensitive C-reactive protein (hs-CRP) concentrations independently predict the development of diabetes, metabolic syndrome and cardiovascular disease. However, the impact of dietary factors on serum hs-CRP concentrations in diabetic patients has received limited attention. We aimed to investigate the association between dietary factors and hs-CRP, among diabetic patients with and without hypertension and healthy subjects. METHODS: In this cross-sectional study, diabetics with (n=325) and without hypertension (n=599) and healthy individuals (n=1220) were recruited in Mashhad, Iran...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28877318/peripheral-vascular-endothelial-dysfunction-in-central-serous-chorioretinopathy
#20
Nan-Kai Wang, Yun Fu, Jung-Pan Wang, Eugene Yu-Chan Kang, An-Lun Wu, Yun-Ju Tseng, Lung-Kun Yeh, Kuan-Jen Chen, Wei-Chi Wu, Wan-Jing Ho, Chi-Chun Lai
Purpose: To explore the pathophysiology of central serous chorioretinopathy (CSC) by comparing peripheral vascular endothelium function in patients with CSC and control subjects. Methods: This study included 34 patients with CSC who attended the Department of Ophthalmology and 34 healthy age- and sex-matched healthy control subjects from a routine physical check-up population. Endothelium-dependent flow-mediated vasodilation (FMD) and endothelium-independent nitroglycerine-mediated vasodilation (NMD) were measured using high-resolution, two-dimensional ultrasonographic imaging of the brachial artery...
September 1, 2017: Investigative Ophthalmology & Visual Science
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