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High sensitivity CRP

Alireza Farsad-Naeimi, Mohammad Alizadeh, Ali Esfahani, Esmaeil Darvish Aminabad
A growing body of evidence indicates that inflammation is associated with tumorigenesis, metastasis and chemotherapeutic resistance in patients with colorectal cancer (CRC). Natural flavonoids are promising agents for inflammation-related tumor progression in patients with CRC. This study aimed to assess the efficacy of flavonoid fisetin supplementation on the inflammatory status and matrix metalloproteinase (MMP) levels in these patients. In this double-blind, randomized placebo-controlled clinical trial, 37 CRC patients undergoing chemotherapy were assigned to receive either 100 mg fisetin (n = 18) or placebo (n = 19) for seven consecutive weeks...
March 15, 2018: Food & Function
Liqin Gao, Bin Yang, Hairong Zhang, Qishui Ou, Yulan Lin, Mei Zhang, Zhenhuan Zhang, Sunghee Kim, Bing Wu, Zeng Wang, Lengxi Fu, Jingan Lin, Ruiqing Chen, Ruilong Lan, Junying Chen, Wei Chen, Long Chen, Hengshan Zhang, Deping Han, Jingrong Chen, Paul Okunieff, Jianhua Lin, Lurong Zhang
Early diagnosis of sepsis is critical for successful treatment. The clinical value of DcR3 in early diagnosis of sepsis was determined in a dynamic follow-up study. Alterations in plasma levels of DcR3, PCT, CRP, and IL-6 were measured by ELISA and compared among patients with sepsis ( n = 134), SIRS ( n = 60) and normal adults ( n = 50). Correlations and dynamic patterns among the biomarkers, APACHE II scores, clinical outcomes, and pathogens were also examined. Plasma DcR3 was significantly increased in sepsis compared to SIRS and normal adults (median 3...
February 16, 2018: Oncotarget
Guner Cicek, Osman Imamoglu, Abdullah Gullu, Oguzhan Celik, Oguzhan Ozcan, Esin Gullu, Faruk Yamaner
The purpose of this study is to investigate the effect of 16 weeks step-aerobic exercises and core exercises on left ventricular structure and function with some physiological parameters in sedentary women. Methods: To achieve the purpose of this study, a total of 45 volunteers including (step-aerobic group (SAG, n = 25), core exercise group (CEG, n = 20) were selected as participants. Two different exercises were applied for 4 days a week, throughout 16 weeks, within 60 minutes for each exercise with the intensity of heart rate (HR) 60-70 percent...
December 2017: Journal of Exercise Science and Fitness
Miwa Isshiki, Satoshi Hirayama, Tsuyoshi Ueno, Masayuki Ito, Ayaka Furuta, Kouji Yano, Kotoko Yamatani, Masami Sugihara, Mayumi Idei, Takashi Miida
BACKGROUND: Rapid turnover proteins (RTPs), such as transthyretin (TTR), retinol binding protein (RBP), and transferrin (Tf), provide an accurate assessment of nutritional status but are susceptible to inflammation. Lipid-related markers, which have short half-lives in serum, may be better suited for nutritional assessment. We sought to identify sensitive nutritional markers unaffected by inflammation. METHODS: Fasting serum samples were collected from 30 malnourished inpatients and 25 healthy volunteers...
March 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Cheng-Jin You, Dan Liu, Li-Li Liu, Guo-Zhong Li
The present study was to examine the relationship between white matter lesions (WMLs) and insulin resistance (IR) in patients with acute stroke and evaluate clinical prognosis.Around 200 patients with initial onset of acute stroke including 146 patients (73.0%) with WMLs and 54 patients (27%) without WMLs were analyzed by neuropsychological scales. Fasting blood glucose (FBG), fasting insulin, blood lipid, homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), creatinine, and uric acid, diabetes mellitus (DM), prediabetes (PD), and normal glucose (NG) were determined according to HbA1c levels...
March 2018: Medicine (Baltimore)
Keenan A Walker, Jeremy Walston, Rebecca F Gottesman, Anna Kucharska-Newton, Priya Palta, B Gwen Windham
Background: Evidence suggests systemic inflammation may have a mechanistic role in age-related frailty, yet prospective data is limited. We examined whether systemic inflammation during midlife was associated with late-life frailty within the community-based Atherosclerosis Risk in Communities Study. Methods: Plasma levels of four inflammatory markers (fibrinogen, von Willebrand factor, and Factor VIII, and white blood cell count) were measured during Visit 1 (1987-89; mean age: 52[5]), standardized into z-scores, and combined to create an inflammation composite score...
March 9, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Sara Abolahrari-Shirazi, Javad Kojuri, Zahra Bagheri, Zahra Rojhani-Shirazi
Background: This study aimed to compare the effects of combined endurance-resistance training (CT) versus endurance training (ET) on some cardiovascular markers in patients with heart failure after percutaneous coronary intervention (PCI). Materials and Methods: The study applied a randomized, controlled design in which 75 patients with heart failure who had undergone PCI were randomly assigned to one of three groups: ET, CT, and control. The ET group performed ET for 45 min, three times a week for 7 weeks...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Li Yunchun, Wang Yue, Fang Zhong Jun, Su Qizhu, Ding Liumei
OBJECTIVES: To investigate the serum level of Myeloid-Related Protein 8/14 complex (MRP8/14) and to predict and monitor the response to biologic treatment in rheumatoid arthritis (RA) patients. METHODS: Each patient underwent clinical examination and blood sampling for assessment of serum high-sensitivity C-reactive protein (hs-CRP) levels, erythrocyte sedimentation rate (ESR), rheumatoid factors (RF), anti-cyclic citrullinated protein antibodies (anti-CCP), and serum concentrations of MRP8/14 protein complexes (myeloid-related proteins, MRP8/14) were measured at baseline, and weeks 4 and 12 (after initiation of treatment)...
January 2018: Annals of Clinical and Laboratory Science
Vajihe Izadi, Fahimeh Haghighatdoost, Parisa Moosavian, Leila Azadbakht
BACKGROUND: There are no investigations regarding the effects of consuming low-energy-dense diets rich in multiple functional foods on weight-loss maintenance, inflammatory markers, and cardiovascular disease (CVD) risk factors simultaneously. METHOD: This randomized controlled trial design was conducted on 90 men and women who were under a previous weight loss diet. Three months of intervention with recruitment at Allzahra Hospital, Isfahan, Iran, was done. Intervention was conducted following achieving 7-11 kg weight loss...
March 12, 2018: Journal of the American College of Nutrition
Ines Delgado, Lison Huet, Sandra Dexpert, Cédric Beau, Damien Forestier, Patrick Ledaguenel, Agnès Aubert, Julie Sauvant, Bruno Aouizerate, Eric Magne, Lucile Capuron
BACKGROUND: Recent reports suggest that the risk of depressive symptoms in obesity is potentiated in subjects presenting a metabolically unhealthy phenotype. Inflammation is often considered a defining criteria of metabolic health. However, this factor may drive the association of metabolic health with depressive symptoms given its well-known role in the pathophysiology of depression. This study aimed at determining the relative contribution of inflammation and metabolic abnormalities to depressive symptoms in obesity...
March 6, 2018: Psychoneuroendocrinology
Raim Iliaz, Tahsin Ozpolat, Bulent Baran, Kadir Demir, Sabahattin Kaymakoglu, Fatih Besisik, Filiz Akyuz
OBJECTIVES: Spontaneous bacterial peritonitis (SBP) is a common and high-mortality infectious complication of patients with cirrhosis. New inflammatory markers are associated with morbidity/mortality in various diseases. The aim of our study was to find the 30-day mortality rate of SBP and their predictors. PATIENTS AND METHODS: Seventy patients with cirrhosis complicated with SBP and 55 non-SBP controls were enrolled into the study, and patients were evaluated for mortality rate and its predictors...
March 8, 2018: European Journal of Gastroenterology & Hepatology
Özcan Örsçelik, Buğra Özkan, Ayça Arslan, Emre Ertan Şahin, Ozan Sakarya, Orçun Ali Sürmeli, Şenay Balcı Fidancı, Ahmet Çelik, Burak Yavuz Çimen, İsmail Türkay Özcan
OBJECTIVE: Heart failure (HF) is a clinical syndrome resulting from structural or functional damages. Although clinical trials have shown that the plasma renin-angiotensin system (RAS) activation decreases HF functional status and increases hospitalization for HF patients, the effect of intrarenal RAS activity is still unknown. In this study, we investigated the relationship between the New York Heart Association (NYHA) class, duration, and number of hospitalizations in the previous year and urinary angiotensinogen (UAGT) in patients with HF with reduced ejection fraction (HFrEF)...
March 2018: Anatolian Journal of Cardiology
Yago Leira, Pablo Ameijeira, Clara Domínguez, Rogelio Leira, Juan Blanco
BACKGROUND: To evaluate the contribution of chronic periodontitis (CP) to serum procalcitonin (proCT) levels in chronic migraine (CM) patients in a cross-sectional study. METHODS: We included 138 subjects divided into 4 groups based on clinical features of CM and periodontal parameters: systemically and periodontally healthy individuals (n = 37), systemically healthy and CP patients (n = 19), CM and periodontally healthy patients (n = 34), and CM+CP patients (n = 48)...
March 9, 2018: Journal of Periodontology
K Tabeta, M Hosojima, M Nakajima, S Miyauchi, H Miyazawa, N Takahashi, Y Matsuda, N Sugita, Y Komatsu, K Sato, T Ishikawa, K Akiishi, K Yamazaki, K Kato, A Saito, H Yoshie
BACKGROUND AND OBJECTIVES: Previous reports suggest that several serum biomarkers play roles in the pathogenesis, inflammatory response, and oxidative stress in periodontitis caused by bacterial infections, linking chronic periodontitis to atherosclerotic vascular disease (ASVD). The aim of this preliminary study was to investigate, in a Japanese cross-sectional community survey, potential serum biomarkers of periodontitis that are associated with ASVD and chronic periodontitis. MATERIAL AND METHODS: The study cohort included a total of 108 male subjects who underwent annual health examinations...
March 8, 2018: Journal of Periodontal Research
Jyrki K Virtanen, Jaakko Mursu, Sari Voutilainen, Tomi-Pekka Tuomainen
BACKGROUND/OBJECTIVES: There are concerns that high intake of n-6 polyunsaturated fatty acids (PUFA) may promote inflammation, because the end-product of n-6 PUFA metabolism, arachidonic acid, is a precursor for pro-inflammatory eicosanoids. Our aim was to investigate cross-sectional associations of the serum n-6 PUFAs, objective biomarkers for exposure, with serum high-sensitivity C-reactive protein (CRP), a key inflammation marker. SUBJECTS/METHODS: The study included 1287 generally healthy men aged 42-60 years from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study, examined in 1984-1989...
March 2018: European Journal of Clinical Nutrition
Mustafa Keleşoğlu, Fuat Kızılay, Burcu Barutçuoğlu, Güneş Başol, Fulden Saraç, Işıl Mutaf, Bülent Semerci
Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA2) which is believed to play a role in atherosclerotic inflammatory process due to its function in hydrolysis of phospholipids and release of pro-inflammatory products, is considered as a novel biomarker for vascular risk. In this study we aimed to investigate the alterations in Lp-PLA2 and its relationship with other cardiovascular risk factors in patients with testosterone deficiency. Material and methods: Forty hypogonadic male and 30 healthy male aged between 18-50 years were enrolled in this study...
March 2018: Turkish Journal of Urology
K-W Ren, N Shen, J-L Tang, L-M Nong, Y-Q Gu
OBJECTIVE: To investigate the effects of ulinastatin on inflammatory response and cognitive function after hip arthroplasty for the elderly patients with femoral neck fracture. PATIENTS AND METHODS: A total of 80 patients with femoral neck fracture receiving hip arthroplasty in our hospital from August 2016 to February 2017 were selected and divided into observation group (n=40) and control group (n=40) using a random number table. The control group was treated with hip arthroplasty and symptomatic and supportive treatment after operation, while the observation group was treated with ulinastatin based on the treatment means of control group...
February 2018: European Review for Medical and Pharmacological Sciences
Alberto Cappelletti, Domenico Astore, Cosmo Godino, Barbara Bellini, Valeria Magni, Monica Mazzavillani, Matteo Pagnesi, Eustachio Agricola, Roberto Chiesa, Antonio Colombo, Alberto Margonato
BACKGROUND: Data concerning the relationship between cardiovascular risk factors, plasmatic markers, carotid disease and extent of coronary lesions are lacking. OBJECTIVES: To evaluate the role of cardiovascular risk factors, plasmatic levels of high sensitivity C-reactive protein (hs-CRP), fibrinogen, lipoprotein(a), and carotid plaque extension in predicting the severity of coronary artery disease (CAD). METHODS: We analyzed 574 subjects undergoing first coronary angiography...
April 15, 2018: International Journal of Cardiology
Slobodan Tanaskovic, Djordje Radak, Nikola Aleksic, Branko Calija, Vera Maravic-Stojkovic, Dragoslav Nenezic, Nenad Ilijevski, Petar Popov, Goran Vucurevic, Srdjan Babic, Predrag Matic, Predrag Gajin, Dragan Vasic, Zoran Rancic
BACKGROUND: Inflammation is one of the mechanisms that leads to carotid restenosis (CR). The aim of this study was to examine the influence of increased values of inflammation markers (high-sensitivity C-reactive protein [hs-CRP], C3 complement, and fibrinogen) on CR development after eversion carotid endarterectomy (CEA). METHODS: A consecutive 300 patients were included in the study, in which eversion CEA was performed between March 1 and August 1, 2010. Demographic data, atherosclerosis risk factors, comorbidities, and ultrasound plaque characteristics were listed in relation to potential risk factors for CR...
March 1, 2018: Journal of Vascular Surgery
F Carbone, E Nulli Migliola, A Bonaventura, A Vecchié, S De Vuono, M A Ricci, G Vaudo, M Boni, F Dallegri, F Montecucco, G Lupattelli
BACKGROUND & AIMS: Gender-related differences represent an emerging investigation field to better understand obesity heterogeneity and paradoxically associated cardiovascular (CV) risk. Here, we investigated if high-sensitivity C-reactive protein (hs-CRP) might differently affect adiposity and predict the clinical response to bariatric surgery in obese males and females. METHODS AND RESULTS: In 110 morbidly obese patients undergoing laparoscopic sleeve gastrectomy, hs-CRP as well as anthropometric assessment of adiposity, completed by electric bioimpedance and ultrasonography quantification of visceral fat area (VFA), were measured before and one year after surgery...
February 2, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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