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High sensitivity CRP

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https://www.readbyqxmd.com/read/28640843/metabolic-milieu-associates-with-impaired-skeletal-characteristics-in-obesity
#1
Heli T Viljakainen, Heikki A Koistinen, Taina Tervahartiala, Timo Sorsa, Sture Andersson, Outi Mäkitie
High leptin concentration, low-grade inflammation, and insulin resistance often coexist in obese subjects; this adverse metabolic milieu may be the main culprit for increased fracture risk and impaired bone quality seen in patients with type 2 diabetes. We examined the associations of leptin, hs (high sensitivity)- CRP and insulin resistance with bone turnover markers (BTMs) and bone characteristics in 55 young obese adults (median BMI 40 kg/m2) and 65 non-obese controls. Mean age of the subjects was 19.5 ± 2...
2017: PloS One
https://www.readbyqxmd.com/read/28637038/synergic-impact-of-vascular-calcification-and-low-autonomic-tone-in-mortality-of-hemodialysis-patients
#2
Hwee-Yeong Ng, Shu-Kai Hsueh, Yueh-Ting Lee, Terry Ting-Yu Chiou, Pei-Chen Huang, Chien-Te Lee
BACKGROUND: Both cardiovascular calcification and autonomic dysfunction are frequently encountered in hemodialysis patients. We aimed to investigate the relationship between cardiovascular calcification and heart rate variability (HRV) and their influence on long-term outcome. METHODS: Seventy-eight hemodialysis patients underwent echocardiogram and radiography of the pelvis and hands to identify valvular and vascular calcification. HRV was evaluated using a commercial machine...
June 22, 2017: Nephron
https://www.readbyqxmd.com/read/28636270/c-reactive-protein-and-progression-of-vision-loss-in-retinitis-pigmentosa
#3
Yusuke Murakami, Yasuhiro Ikeda, Shunji Nakatake, Kohta Fujiwara, Takashi Tachibana, Noriko Yoshida, Shoji Notomi, Toshio Hisatomi, Shigeo Yoshida, Tatsuro Ishibashi, Koh-Hei Sonoda
PURPOSE: Chronic inflammation is involved in retinitis pigmentosa (RP). We demonstrated previously that intraocular inflammatory levels, as measured by slit-lamp ophthalmoscopy or laser flare photometry, are inversely correlated with central visual function in patients with RP. Here, we investigated the relationship between serum high-sensitivity C-reactive protein (hs-CRP) and visual parameters in RP. METHODS: We studied 58 consecutive typical patients with RP <40 years old and 29 age- and gender-matched controls...
June 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28632493/interplay-between-papp-a-inflammation-and-adiposity-in-patients-with-angiographically-proven-acute-coronary-syndrome-acs
#4
Khageshwar Mahato, Moushumi Lodh, Ashok Parida, Ashok Kr Ahirwar, Rashmi Rasi Datta, Binita Goswami
Introduction Studies conducted in the recent past have demonstrated the role of inflammation, obesity and dysfunctional insulin signaling as contributing factors in the pathogenesis of acute coronary syndrome (ACS). However, pharmacological interventions targeting a single pathway have not proven useful in the long run. This indicates that a synergism occurs between the various risk factors and hence calls for a combinatorial approach. This study was planned to study the interplay, if any, between pregnancy associated plasma protein-A (PAPP-A), inflammation and adiposity in patients with ACS...
June 21, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28631693/-independent-risk-factors-for-severe-cardiovascular-events-in-male-patients-with-gout-results-of-a-7-year-prospective-study
#5
M S Eliseev, I S Denisov, E I Markelova, S I Glukhova, E L Nasonov
AIM: To determine risk factors for severe cardiovascular (CV) events (CVEs) in male patients with crystal-verified gout. SUBJECTS AND METHODS: 251 male patients with crystal-verified gout were prospectively followed up in 2003 to 2013. The mean follow-up period was 6.9±2.0 years. New severe CVE cases and deaths were recorded. Logistic regression was used to analyze the impact of traditional and other risk factors and allopurinol use on the risk for severe CVEs...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28624820/an-elevated-high-sensitivity-c-reactive-protein-level-is-associated-with-unfavorable-functional-outcomes-of-small-artery-occlusion-in-patients-without-diabetes
#6
Yuan Gao, Ji Liu, Wanjun Wang, Chunlin Gao, Changshen Yu, Shoufeng Liu, Jialing Wu
BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is associated with a risk of causing diabetes mellitus and ischemic stroke. However, the association between hs-CRP levels and functional outcome after small-artery occlusion (SAO) is unknown. METHODS: Data for 836 patients diagnosed with SAO were collected from the Department of Neurorehabilitation of Huanhu Hospital. Hs-CRP values were classified according to quartiles (<0.67, 0.67 to <1.46, 1.46 to <3...
June 17, 2017: European Neurology
https://www.readbyqxmd.com/read/28624750/long-term-indoor-air-conditioner-filtration-and-cardiovascular-health-a-randomized-crossover-intervention-study
#7
Hsiao-Chi Chuang, Kin-Fai Ho, Lian-Yu Lin, Ta-Yuan Chang, Gui-Bing Hong, Chi-Ming Ma, I-Jung Liu, Kai-Jen Chuang
The association of short-term air pollution filtration with cardiovascular health has been documented. However, the effect of long-term indoor air conditioner filtration on the association between air pollution and cardiovascular health is still unclear. We recruited 200 homemakers from Taipei and randomly assigned 100 of them to air filtration or control intervention; six home visits were conducted per year from 2013 to 2014. The participants under air filtration intervention during 2013 were reassigned to control intervention in 2014...
June 15, 2017: Environment International
https://www.readbyqxmd.com/read/28624718/microparticles-in-acute-coronary-syndrome
#8
Chrysostomos A Mavroudis, Despina Eleftheriou, Ying Hong, Bikash Majumder, Sudheer Koganti, Ray Sapsford, Janet North, Mark Lowdell, Nigel Klein, Paul Brogan, Roby D Rakhit
BACKGROUND: Emerging evidence supports the role of cell-derived microparticles (MPs) in the pathophysiology of acute coronary syndrome (ACS). OBJECTIVES: To explore the relationship between coronary and systemic MP levels, investigate the correlation between MPs, inflammatory markers and Troponin T in patients with ACS. METHODS: Thirty seven patients with ACS scheduled for percutaneous coronary interventions (PCI) were studied. Eleven patients with stable angina (SA) were included as a control group...
June 9, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28622624/primary-myelofibrosis-older-age-and-high-jak2v617f-allele-burden-are-associated-with-elevated-plasma-high-sensitivity-c-reactive-protein-levels-and-a-phenotype-of-progressive-disease
#9
Giovanni Barosi, Margherita Massa, Rita Campanelli, Gabriela Fois, Paolo Catarsi, Gianluca Viarengo, Laura Villani, Valentina Poletto, Tiziana Bosoni, Umberto Magrini, Robert P Gale, Vittorio Rosti
We measured plasma levels of high-sensitivity C-reactive protein (hs-CRP) in 526 subjects with primary myelofibrosis (PMF). Thirty-eight percent had an elevated hs-CRP level (≥0.3mg/dL). Elevated hs-CRP levels were associated with a progressive disease phenotype, including anemia, high white blood cell count, low platelet count, increased splenomegaly, increased risk of blast transformation, and worse survival. Age≥52years, but no other demographic characteristics, was associated with an elevated hs-CRP level in multivariable logistic regression (odds ratio [OR], 4...
June 7, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28619601/ldl-cholesterol-was-more-strongly-associated-with-percent-body-fat-than-body-mass-index-and-waist-circumference-in-a-health-screening-population
#10
Eiji Oda
AIMS: To compare correlations between changes in cardiovascular risk factors and those in obesity indices and to compare associations with incident hyper-LDL cholesterolemia among obesity indices. METHODS: Correlation coefficients were calculated between 7-year changes in cardiovascular risk factors and those in body mass index (BMI), waist circumference (WC) and percent body fat (PBF) in 634 men and 396 women who used no antihypertensive, antidiabetic or antihyperlipidemic drugs...
June 12, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28619247/childhood-maltreatment-severity-is-associated-with-elevated-c-reactive-protein-and-body-mass-index-in-adult-with-schizophrenia-and-bipolar-diagnoses
#11
Monica Aas, Ingrid Dieset, Sigrun Hope, Eva Hoseth, Ragni Mørch, Elina Reponen, Nils Eiel Steen, Jannicke F Anderssen, Thor Ueland, Pål Aukrust, Ingrid Agartz, Ole A Andreassen, Ingrid Melle
BACKGROUND: Several studies have described an association between childhood maltreatment and inflammatory markers in the psychotic disorders (schizophrenia [SZ] and bipolar disorder [BD]). Previous studies have been relatively small (<50 participants), and the severity of abuse and the putative influence of body mass index (BMI) have not been properly investigated. METHODS: The combined effects of childhood abuse severity and clinical diagnosis on inflammatory markers were investigated in a large sample (n=483) of patients with a disorder on the psychosis spectrum and in healthy controls (HCs)...
June 12, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28619236/the-effect-of-isolated-soy-protein-adjunctive-with-flaxseed-oil-on-markers-of-inflammation-oxidative-stress-acute-phase-proteins-and-wound-healing-of-burn-patients-a-randomized-clinical-trial
#12
Siavash Babajafari, Masoumeh Akhlaghi, Seyed Mohammad Mazloomi, Mehdi Ayaz, Ali Noorafshan, Peyman Jafari, Abdollah Hojhabrimanesh
INTRODUCTION: The objective was to determine the effect of isolated soy protein (ISP) and flaxseed oil (FO) on inflammatory and oxidative stress indices, acute phase proteins, and wound healing of burn patients. METHODS: One hundred eighty-eight patients were assessed for eligibility in this randomized controlled trial. Of these, seventy-three eligible patients (total burn surface area 20-50%) were randomly assigned to 3 isocaloric groups, labeled as control (wheat flour+corn oil (CO)), ISP+FO, and ISP+CO, to receive these nutrients for 3 weeks...
June 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28616918/-value-of-procalcitonin-high-sensitivity-c-reactive-protein-and-pancreatic-stone-protein-in-predicting-prognosis-of-children-with-sepsis
#13
Jun-Ming Huo, Rui Huo, Ling Hu, Si-Wei Lu, Jian Zu
OBJECTIVES: To determine the value of procalcitonin (PCT), high sensitivity C-reactive protein (hs-CRP) and pancreatic stone protein(PSP) in predicting the prognosis of children with sepsis. METHODS: A total of 106 hospitalized children [(4.4±1.6) year-old] with sepsis were enrolled in this study. The expressions of PTC, hs-CRP and PSP in the serum samples of the children were detected on the first day of admission to hospital. Pearson correlation analyses were performed to test the correlations between pediatric critical illness score (PCIS) and PTC, hs-CRP and PSP...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28615764/evaluation-of-antioxidant-status-high-sensitivity-c-reactive-protein-and-insulin-resistance-in-male-chronic-opiate-users-without-comorbidities
#14
Purvi Purohit, Naresh Nebhinani, Praveen Sharma
BACKGROUND: There is a paucity of data on frequency of metabolic syndrome (MS), insulin resistance (IR), and oxidative stress in Indian opiate users without comorbidities. OBJECTIVES: To determine the influence of opiate use on frequency of MS, homeostasis model assessment for IR (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress in opiate-dependent male patients without comorbidities. METHODS: Participants (n = 120) were grouped as controls (Group I), pure opiate dependents (Group II), opiate + tobacco dependents (Group III), and tobacco dependents (Group IV) with a minimum of 1-year dependence participated in the study...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28612906/the-influence-of-plasma-25-oh-vitamin-d-levels-in-acute-st-elevation-myocardial-infarction
#15
Ömer Şen, Mustafa Topuz, Armağan Acele, Oğuz Akkuş, Ahmet Oytun Baykan, Mevlüt Koç
BACKGROUND: The preventive role of acute occurring of collateral circulation (AOCC) to infarct related artery (IRA) in patients presenting with acute ST-segment elevation myocardial infarction (STEMI) is well known. Therefore, we aimed to investigate whether there is an association between admission plasma 25-(OH) vitamin D (25(OH)D3) levels and grade of collateralization in patients with STEMI. METHODS: We prospectively included 369 STEMI patients within the first 12 h of symptoms onset...
June 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28612585/pancreatic-cancer-is-associated-with-peripheral-leukocyte-oxidative-dna-damage
#16
Ashraf Mohamadkhani, Akram Pourshams, Jessica Viti, Filippo Cellai, Kamran Mortazavi, Maryam Sharafkhah, Masoud Sotoudeh, Reza Malekzadeh, Paolo Boffetta, Marco Peluso
Background: DNA damage accumulation has been linked to the cancer phenotype. The purpose of this study was to compare the levels of DNA base 8-hydroxy-2′-deoxyguanosine (8-OHdG) and C-reactive protein (CRP) inflammatory markers in healthy controls and pancreatic cancer patients from a hospital-based case-control study. Materials and Methods: Fifty-five pancreatic cancer patients and 55 healthy controls were enrolled from a pool of patients referred to the Endoscopic Ultrasound (EUS) center. Analysis of DNA content of peripheral blood cells was conducted for 8-OHdG with the 32P-postlabelling assay...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28610945/atherosclerosis-associated-with-dynamic-inflammation-changes-after-multifactorial-intervention-in-short-duration-type-2-diabetes-a-randomized-controlled-10-year-follow-up-trial
#17
Chunhong Shi, Lili Men, Cuiping Yu, Junjie Yao, Ran Bai, Yu Yang, Lipeng Sun, Guohua Sun, Guirong Song, Yuhong Zhang, Qian Xing, Jianling Du
PURPOSE: To analyze the impact of dynamic changes in inflammation on atherosclerosis in short-duration type 2 diabetes after multifactorial intervention. METHODS: In this randomized controlled study, a total of 150 type 2 diabetes patients who had a mean age of 49.8±7.3years, 51% male, with disease duration <1year and without evidence of atherosclerosis were randomized into an intensive intervention group (IG), in which patients received multiple risk factors intervention by the special project team and tried to reach the pre-determined intervention goals, and a conventional group (CG), in which patients received standard diabetes care by the clinic doctor...
May 25, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28607566/comparative-effects-of-carbohydrate-versus-fat-restriction-on-metabolic-profiles-biomarkers-of-inflammation-and-oxidative-stress-in-overweight-patients-with-type-2-diabetic-and-coronary-heart-disease-a-randomized-clinical-trial
#18
Fariba Raygan, Fereshteh Bahmani, Ebrahim Kouchaki, Esmat Aghadavod, Sahar Sharifi, Elmira Akbari, Akbar Heidari, Zatollah Asemi
BACKGROUND: This study was conducted to establish the comparative effects of carbohydrate versus fat restriction on metabolic indices in Type 2 diabetic (T2D) patients with coronary heart disease (CHD). METHODS: This randomized, clinical trial was done among 56 overweight persons with T2D and CHD aged 40-85 years old. The patients were randomly allocated to take either a high-carbohydrate (HC) diet (60-65% carbohydrates and 20-25% fats) (n = 28) or a restricted carbohydrate (RC) diet (43-49% carbohydrate and 36-40% fats) (n = 28) for 8 weeks to determine metabolic status...
November 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28606604/the-ability-of-the-wide-range-crp-assay-to-classify-individuals-with-low-grade-inflammation-into-cardiovascular-risk-groups
#19
Tomer Ziv-Baran, Shani Shenhar-Tsarfaty, Inbal Etz-Hadar, Ilana Goldiner, Ahuva Gottreich, Yifat Alcalay, David Zeltser, Itzhak Shapira, Yoel Angel, Limor Friedensohn, Michal Ehrenwald, Shlomo Berliner, Ori Rogowski
BACKGROUND: High sensitivity C-reactive protein (hsCRP) has become a routine assessment tool to discriminate between patients at low, intermediate or high risk for cardiovascular events using the threshold values of 1 and 3mg/L, respectively. Over the past years, several studies have proposed the wide range C-reactive protein (wrCRP) as an alternative to the hsCRP in various clinical scenarios. However, the potential use of wrCRP in assessing the cardiovascular risk has not yet been evaluated...
June 9, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28604834/associations-of-brain-natriuretic-peptide-high-sensitive-troponin-t-and-high-sensitive-c-reactive-protein-with-outcomes-in-severe-aortic-stenosis
#20
Andreas Auensen, Amjad Iqbal Hussain, Ragnhild Sørum Falk, Marte Meyer Walle-Hansen, Jorun Bye, Kjell Ingar Pettersen, Pål Aukrust, Thor Ueland, Lars Lysgaard Gullestad
OBJECTIVES: Among patients with severe aortic stenosis (AS), we investigated the associations of N-terminal pro-natriuretic peptide (NT-proBNP), high-sensitive troponin T (hsTnT), and high-sensitive C-reactive protein (hs-CRP) with 3-year mortality and major adverse cardiovascular events (MACE) during 1 year. METHODS: This observational cohort study prospectively enrolled 442 patients with severe AS who were referred for evaluation of possible valve replacement...
2017: PloS One
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