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High sensitivity CRP

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https://www.readbyqxmd.com/read/28090279/association-of-atp-binding-cassette-transporter-a1-abca1-565-c-t-gene-polymorphism-with-hypoalphalipoproteinemia-and-serum-lipids-il-6-and-crp-levels
#1
Mohammad Mahdi Babashamsi, Sohrab Halalkhor, Hamid Moradi Firouzjah, Hadi Parsian, Seyed Farzad Jalali, Mohammad Babashamsi
BACKGROUND: ATP-binding cassette transporter A1 (ABCA1) is a membrane integral protein which plays a vital role in High Density Lipoprotein (HDL) metabolism and exerts a protective effect against Hypoalphalipoproteinemia (HA) by mediation of rate-limiting step in HDL biogenesis. In addition, this protein possesses anti-inflammatory effects by inhibiting the production of some inflammatory cytokines in macrophages. This study investigated the association of ABCA1-565 C/T gene polymorphism with HA and serum lipids, IL-6 and CRP levels...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28089751/reduced-serum-milk-fat-globule-epidermal-growth-factor-8-mfg-e8-concentrations-are-associated-with-an-increased-risk-of-microvascular-complications-in-patients-with-type-2-diabetes
#2
Jinxing Quan, Guohua Sun, Juxiang Liu, Guanghao Xia, Lijuan Zhang, Yonghong Li, Zubang Zhou, L V Yaya, Suhong Wei, Jing Liu
BACKGROUND: The association between serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations and vascular complications in T2DM remains unclear. METHODS: A total of 149 patients with T2DM were included. The serum concentrations of MFG-E8, glycosylated hemoglobin (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) were measured. RESULTS: There was no significant difference in serum MFG-E8 concentrations between the T2DM group and the T2DM with subclinical atherosclerosis (AS) group (615...
January 12, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28078862/a-placebo-controlled-trial-of-a-proprietary-lipid-lowering-nutraceutical-supplement-in-the-management-of-dyslipidemia
#3
M Houston, R Rountree, J Lamb, S Phipps, S Meng, B Zhang
There is an ever growing emergence in the popularity of patient-driven care. As this health and wellness model grows, inquiries into diet, lifestyle, and supplemental approaches will continue to become a focal point for the healthcare consumer. Because of this, the aim of this study is to determine the tolerability, and overall effectiveness of a proprietary multi-ingredient lipid-lowering supplement in subjects with dyslipidemia. Forty participants were recruited for a single-center, double-blind randomized, placebocontrolled trial...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28077136/increased-leptin-adiponectin-ratio-relates-to-low-normal-thyroid-function-in-metabolic-syndrome
#4
Lynnda J N van Tienhoven-Wind, Robin P F Dullaart
BACKGROUND: Low-normal thyroid function within the euthyroid range may contribute to increased atherosclerosis susceptibility. The leptin/adiponectin (L/A) ratio is associated with cardiovascular disease and reflects adipose tissue dysfunction. Relationships of the L/A ratio with low-normal thyroid function are unknown. METHODS: Relationships of thyroid stimulating hormone (TSH) and free thyroxine (free T4) with leptin, adiponectin and the L/A ratio in euthyroid subjects were documented in 67 fasting subjects with metabolic syndrome (Mets) and 86 euthyroid subjects without MetS (TSH and free T4 levels within the institutional reference range)...
January 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28074977/-association-of-c-reactive-protein-levels-with-metabolic-syndrome-in-adults-a-population-based-study
#5
Patricia Bustos, Bernardita Rosas, Pablo Román, Juan Villagrán, Hugo Amigo
BACKGROUND: Metabolic syndrome is highly prevalent among adults in Chile and represents a health risk. AIM: To determine the relationship between metabolic syndrome (MetS) and its components, with C reactive protein levels (CRP) as an inflammation marker. MATERIAL AND METHODS: The population studied consisted of 736 individuals born in a hospital from Valparaíso Region, aged between 32-38 years at the time of the study. MetS was identified according to the Adult Treatment Panel (ATP) III guidelines and inflammation was measured using ultra-sensitive CRP...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28072726/no-further-gain-can-be-achieved-by-calculating-disease-activity-score-in-28-joints-with-high-sensitivity-assay-of-c-reactive-protein-because-of-high-intraindividual-variability-of-c-reactive-protein-a-cross-sectional-study-and-theoretical-consideration
#6
Inger M J Hansen, Amir Emamifar, Rikke A Andreasen, Steen Antonsen
Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision.The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification.This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28069837/high-sensitive-cardiac-troponin-t-as-a-novel-predictor-for-recurrence-of-atrial-fibrillation-after-radiofrequency-catheter-ablation
#7
Koki Nakanishi, Shota Fukuda, Hajime Yamashita, Toshifumi Hasegawa, Michihiko Kosaka, Naoya Shirai, Kenei Shimada, Junichi Yoshikawa, Atsushi Tanaka
AIMS: We aimed to determine whether elevated serum high-sensitive cardiac troponin T (hs-TnT) levels predict atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). METHODS AND RESULTS: We included 125 consecutive patients with AF (paroxysmal, n = 79; persistent, n = 46) who underwent first-time PVI. Serum hs-TnT, high-sensitive C-reactive protein (hs-CRP), atrial natriuretic peptide, and plasma B-type natriuretic peptide levels were measured in venous samples collected before PVI...
January 8, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28066689/c-reactive-protein-in-stable-cystic-fibrosis-an-additional-indicator-of-clinical-disease-activity-and-risk-of-future-pulmonary-exacerbations
#8
Elias Matouk, Dao Nguyen, Andrea Benedetti, Joanie Bernier, James Gruber, Jennifer Landry, Simon Rousseau, Heather G Ahlgren, Larry C Lands, Gabriella Wojewodka, Danuta Radzioch
INTRODUCTION: In stable adult cystic fibrosis (CF) patients, we assessed the role of baseline high sensitivity C-reactive protein (hs-CRP) on CF clinical variables and frequency of intravenous (IV) treated pulmonary exacerbations (PExs) 1-year post-baseline. METHODS: We recruited 51 clinically stable CF patients from our Adult CF Center. We incorporated collected parameters into Matouk CF clinical score and CF questionnaire-revised quality of life score (QOL). We used the clinical minus complications subscores as a clinical disease activity score (CDAS)...
October 14, 2016: Journal of Pulmonary & Respiratory Medicine
https://www.readbyqxmd.com/read/28060925/associations-of-self-reported-sleep-quality-with-circulating-interferon-gamma-inducible-protein-10-interleukin-6-and-high-sensitivity-c-reactive-protein-in-healthy-menopausal-women
#9
Wan-Yu Huang, Chih-Cheng Huang, Chia-Chu Chang, Chew-Teng Kor, Ting-Yu Chen, Hung-Ming Wu
INTRODUCTION: Sleep disturbance is very common in menopausal women and poor sleep quality has been linked to systemic inflammation. However, the impact of poor sleep quality on health outcomes of menopausal women remains unclear. This study evaluated the relationships between sleep quality and inflammation in menopausal women. PARTICIPANTS AND DESIGN: This cross-sectional study enrolled 281 healthy women aged 45 to 60 years. The Pittsburgh Sleep Quality Index (PSQI) was used to measure quality of sleep...
2017: PloS One
https://www.readbyqxmd.com/read/28051885/elevated-serum-interferon-%C3%AE-inducible-protein-10-in-women-with-polycystic-ovary-syndrome
#10
Hongli Deng, Zhibo Li, Guang Liu, Xianhua Li, Yong Chen, Yong Zhang, Yifan Sun, Jinjian Fu
BACKGROUND: Interferon γ-induced protein 10 kDa (IP10/CXCL10) is a chemokine related to endocrine disorders; however, the serum concentrations of IP10 in women with polycystic ovary syndrome (PCOS) have not yet been reported. Therefore, we investigated whether IP10 is increased in PCOS patients and its potential clinical value in PCOS patients. METHODS: For this research, the serum IP10, glucose, insulin, high sensitivity C-reactive protein (hs-CRP), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and total testosterone (TT) concentrations were measured in 60 women with PCOS and healthy controls...
January 4, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28051354/effect-of-almond-supplementation-on-glycemia-and-cardiovascular-risk-factors-in-asian-indians-in-north-india-with-type-2-diabetes-mellitus-a-24-week-study
#11
Seema Gulati, Anoop Misra, Ravindra M Pandey
BACKGROUND: Type 2 diabetes (T2D) statistics have reached menacing proportions in India. Appropriate dietary intervention, as part of healthy lifestyle, is imperative to curb further spread of this disease. OBJECTIVES: This pre-post intervention study was conducted in New Delhi, India, to investigate the effects of daily consumption of almonds for 24 weeks in T2D subjects, specifically on measures of glycemia and cardiovascular disease (CVD) risk factors. METHODS AND STUDY DESIGN: In this study, the 24-week intervention period was preceded by a control diet and exercise run-in period of 3 weeks...
January 4, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28051279/carotid-intima-media-thickness-and-blood-biomarkers-of-atherosclerosis-in-patients-after-stroke-or-myocardial-infarction
#12
Iwona Kurkowska-Jastrzebska, Michał A Karlinski, Beata Błazejewska-Hyzorek, Iwona Sarzynska-Dlugosz, Krzysztof J Filipiak, Anna Czlonkowska
AIM: To test if circulating levels of markers of inflammation, endothelial function, and chronic infections, as well as association between these markers and carotid intima media thickness (CIMT), depend on the stage of atherosclerosis expressed as a history of a major vascular event. METHODS: The associations were analyzed separately in 75 healthy controls, 79 patients 3-6 months after the first-ever non-cardioembolic ischemic stroke (IS), and 37 patients 3-6 months after the first-ever myocardial infarction (MI)...
December 31, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/28049236/nutritional-status-in-adults-with-predialysis-chronic-kidney-disease-know-ckd-study
#13
Young Youl Hyun, Kyu Beck Lee, Seung Hyeok Han, Yeong Hoon Kim, Yong Soo Kim, Sung Woo Lee, Yun Kyu Oh, Dong Wan Chae, Curie Ahn
Adverse changes in nutrition are prevalent and are strong indicators of adverse outcomes in patients with chronic kidney disease (CKD). The International Society of Renal Nutrition and Metabolism (ISRNM) proposed a common nomenclature and diagnostic criteria to identify protein-energy wasting (PEW) in CKD patients. We examined the nutritional status in 1,834 adults with predialysis CKD enrolled in the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD) study. As there was a need for further understanding of nutritional status and associated factors in CKD, we evaluated the prevalence and associated factors of PEW in adults with predialysis CKD...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28042411/clomiphene-citrate-treatment-cycle-outcomes-of-polycystic-ovary-syndrome-patients-based-on-basal-high-sensitive-c-reactive-protein-levels-a-cross-sectional-study
#14
Serkan Kahyaoglu, Omer Hamid Yumuşak, Sebnem Ozyer, Meryem Kuru Pekcan, Merve Erel, Mahmut Nedim Cicek, Salim Erkaya, Yasemin Tasci
BACKGROUND: Polycystic ovary syndrome (PCOS) is highly associated with an ovulatory infertility, features of the metabolic syndrome, including obesity, insulin resistance and dyslipidemia. Serum concentrations of high sensitive C-reactive protein (hs-CRP) were significantly higher in obese than in non-obese PCOS patients at baseline, suggesting a relationship between elevated hs-CRP levels and obesity. The aim of this study was to evaluate whether cycle day 3 hs-CRP levels before clomiphene citrate (CC) treatment would predict cycle outcomes in women with PCOS...
January 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28040383/acute-care-diagnostic-collaboration-bayesian-modeling-comparative-diagnostic-assessment-of-lactate-procalcitonin-and-crp-in-risk-stratified-population-by-mortality-in-emergency-department-meds-score
#15
Laila Cochon, Anais Ovalle, José M Nicolás, Amado Alejandro Baez
OBJECTIVE: To assess and compare the diagnostic value of lactate, procalcitonin (PCT) and C-reactive protein (CRP) in low, moderate, and high-risk stratified population applying Mortality in Emergency Department (MEDS) risk score using Bayesian statistical modeling. METHODS: MEDS criteria was used to risk stratify into low, moderate and high risk. Each population was attributed a percentage risk, and used as pre-test probability in the Bayesian nomogram. Sensitivity and specificity lactate, PCT and CRP were attained from pooled meta-analysis data...
December 19, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28036117/gingivitis-and-lifestyle-influences-on-hs-crp-and-il6-in-adolescents
#16
Vinay Pitchika, Elisabeth Thiering, Isabel Metz, Katrin Rothmaier, Anja Willenberg, Reinhard Hickel, Marie Standl, Thomas Kocher, Joachim Heinrich, Jan Kühnisch
AIM: This cross-sectional study was repeated at two time points and investigated the influence of gingivitis, smoking and body mass index (BMI) on the systemic inflammatory markers high-sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL6) in 10- and 15-year-olds. MATERIALS AND METHODS: The study sample of two birth cohorts, i.e., GINIplus and LISAplus, from the Munich centre consisted of 806 and 846 subjects who were evaluated at 10- and 15-year follow-ups, respectively...
December 30, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28031418/peripheral-inflammatory-biomarkers-for-myocardial-infarction-risk-a-prospective-community-based-study
#17
Zhijun Wu, Zhe Huang, Wei Jin, Eric B Rimm, Alice H Lichtenstein, Penny M Kris-Etherton, Shouling Wu, Xiang Gao
BACKGROUND: Most previous studies regarding chronic inflammation and risk of myocardial infarction (MI) have lacked repeated measures of high-sensitivity C-reactive protein (hs-CRP) and/or white blood cell (WBC) count over time. We examined whether cumulative average and longitudinal changes in these biomarkers were associated with subsequent MI risk. METHODS: In this prospective, community-based study, we included 82544 Chinese participants [66796 men and 15748 women; mean (SD) age 55...
December 28, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/28013285/not-all-plaque-ruptures-are-born-equal-an-optical-coherence-tomography-study
#18
Giancarla Scalone, Giampaolo Niccoli, Hesham Refaat, Rocco Vergallo, Italo Porto, Antonio Maria Leone, Francesco Burzotta, Domenico D'Amario, Giovanna Liuzzo, Francesco Fracassi, Carlo Trani, Filippo Crea
AIMS: Plaque rupture (PR) represents the most common substrate of coronary thrombosis, in at least 50% of cases. Chronic low grade inflammation is a common background for atherosclerosis development; however, increased plaque inflammation may predispose by itself to PR. In the last decade, studies performed by optical coherence tomography (OCT) have allowed to establish the severity of plaque inflammation by assessing macrophage infiltration (MØI). Our retrospective study aimed at assessing the role of plaque inflammation in PR among patients with acute coronary syndrome (ACS) using OCT...
December 24, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28007354/gut-epithelial-barrier-markers-in-patients-with-obstructive-sleep-apnea
#19
Antonia Barceló, Cristina Esquinas, Juan Robles, Javier Piérola, Mónica De la Peña, Irene Aguilar, Daniel Morell-Garcia, Alberto Alonso, Nuria Toledo, Manuel Sánchez-de la Torre, Ferran Barbé
BACKGROUND: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. RESULTS: Compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0...
October 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28000463/obesity-endothelial-function-and-inflammation-the-effects-of-weight-loss-after-bariatric-surgery
#20
Fátima Illán Gómez, Manuel Gonzálvez Ortega, Aurora Aragón Alonso, Sabel Orea Soler, M ª Soledad Alcaraz Tafalla, Matías Pérez Paredes, M ª Luisa Lozano Almela
OBJECTIVE: Obesity is associated with a high risk for atherosclerotic cardiovascular disease. There is a causal association between obesity, inflammation, insulin resistance (IR) and endothelial dysfunction. The aim of this study was to evaluate changes in IR, proinflammatory state and markers of endothelial dysfunction in morbidly obese patients after weight loss following bariatric surgery. METHODS: In this study, we measured the levels of soluble intracellular adhesion molecule-1 (sICAM1), plasminogen activator inhibitor 1 (PAI-1), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) in 79 morbidly obese patients at baseline and 3, 6 and 12 months after gastric bypass...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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