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https://www.readbyqxmd.com/read/29142970/cardiovascular-disease-biomarkers-and-supar-in-predicting-decline-in-renal-function-a-prospective-cohort-study
#1
Salim S Hayek, Yi-An Ko, Mosaab Awad, Hina Ahmed, Brandon Gray, Kareem Mohammed Hosny, Hiroshi Aida, Melissa J Tracy, Changli Wei, Sanja Sever, Jochen Reiser, Arshed A Quyyumi
Introduction: Soluble urokinase-type plasminogen activator receptor (suPAR) strongly predicts outcomes and incident chronic kidney disease (CKD) in patients with cardiovascular disease (CVD). Whether the association between suPAR and CKD is a reflection of its overall association with chronic inflammation and poor CVD outcomes is unclear. We examined whether CVD biomarkers, including high-sensitivity C-reactive protein (hs-CRP), fibrin-degradation products (FDPs), heat-shock protein 70 (HSP-70), and high-sensitivity troponin I (hs-TnI) were associated with a decline in kidney function in the Emory Cardiovascular Biobank cohort, in which suPAR levels were shown to be predictive of both incident CKD and CVD outcomes...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29141361/-effect-of-probucol-on-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#2
X Q Suo, S C Yang, Z H Ma, T T Sun, W Y Zhang, H L Cong, W H Lin, C Z Lu, F S Tian, N K Fu
Objective: To investigate the preventive effect, possible mechanism and safety of probucol on contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods: A total of 641 patients with coronary heart disease were consecutively enrolled from Department of Cardiology, in Tianjin Chest Hospital, Tianjin TEDA International Cardiovascular Hospital, Tianjin First Central Hospital, Tianjin Fourth Central Hospital. They were randomly divided into probucol group (n=321) and control group (n=320)...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29140804/exploration-of-predictive-biomarkers-for-sudden-unexplained-cardiac-death-in-nonelderly-people-a-case-control-study-with-biochemical-parameters-related-to-heart-failure
#3
Sakai Kentaro, Iwadate Kimiharu, Matsumoto Sari, Takasu Shojiro, Kanto Yuko
Sudden unexplained cardiac death (SUCD) can occasionally occur in nonelderly patients with epilepsy, psychiatric disorders, or no medical history. This study was conducted to aim to analyze whether values of the biomarkers for heart failure are associated with the SUCD. Serum concentrations of N-terminal probrain natriuretic peptide, high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor α were analyzed in 57 nonelderly patients with SUCD who was diagnosed at medicolegal autopsy. The subjects were divided into 3 subgroups according to the medical history: (1) epilepsy, (2) psychiatric disorders, and (3) no specific medical history...
November 15, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29135899/new-oxidative-stress-markers-useful-in-the-diagnosis-of-acute-appendicitis-in-children-thiol-disulfide-homeostasis-and-the-asymmetric-dimethylarginine-level
#4
Bahri Elmas, Turan Yildiz, Hayrullah Yazar, Zekeriya İlçe, Ceylan Bal, Betül Özbek, Yusuf Yürümez
OBJECTIVES: The aim of this study was to evaluate 2 new oxidative stress markers, thiol/disulfide homeostasis status and the asymmetric dimethylarginine (ADMA) level, in children with acute appendicitis (AA) and to evaluate their diagnostic utility. METHODS: This case-control study included 45 patients with AA and 35 healthy children. Age, sex, white blood cell count, neutrophil-to-lymphocyte ratio, high-sensitivity C-reactive protein (hs-CRP) level, ultrasonographic findings, thiol/disulfide homeostasis parameters (native and total thiol levels, native thiol/total thiol ratios [antioxidant parameters], and disulfide, disulfide/native thiol, and disulfide/total thiol ratios [oxidant parameters]), and the ADMA level were compared between the 2 groups...
November 14, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29129647/salivary-biomarker-combination-prediction-model-for-the-diagnosis-of-periodontitis-in-a-taiwanese-population
#5
Yun-Chun Wu, Lee Ning, Yu-Kang Tu, Chen-Pang Huang, Nien-Tsu Huang, Yih-Fan Chen, Po-Chun Chang
BACKGROUND/PURPOSE: This study aimed at screening the diagnostic potential of salivary biomarkers and pairing them to establish a prediction model with higher accuracy in diagnosing periodontitis in the Taiwanese population. METHODS: Fifty-seven participants were divided into a non-periodontitis group and a periodontitis group. Salivary biomarkers CRP, IL-6, IL-8, IL-1β, IL-1ra, lactoferrin, MMP-8, MMP-9, PDGF-BB, TNF-α, and VEGF, were analyzed. The potential and reliability of the biomarkers for diagnosing periodontitis were analyzed dichotomously...
November 9, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29128509/monocyte-activation-is-elevated-in-women-with-knee-osteoarthritis-and-associated-with-inflammation-bmi-and-pain
#6
Dessi Loukov, Sarah Karampatos, Monica R Maly, Dawn M E Bowdish
OBJECTIVE: Monocytes contribute to synovitis and disease pathogenesis in OA. Low-grade inflammation occurs in OA and correlates with disease severity and progression. Since monocyte development and function is altered by systemic inflammation, we analyzed monocyte numbers and function between individuals with knee OA and healthy age- and sex-matched controls. DESIGN: We analyzed markers of soluble and cellular inflammation in peripheral blood of women with knee OA and compared them to healthy age- and sex-matched controls...
November 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29128340/the-interaction-between-a-hsp-70-gene-variant-with-dietary-calories-in-determining-serum-markers-of-inflammation-and-cardiovascular-risk
#7
Mehrane Mehramiz, Seyed Mahdi Hassanian, Maryam Mardan-Nik, Alireza Pasdar, Khadijeh Jamialahmadi, Hamid Fiuji, Mehrdad Moetamani-Ahmadi, Seyed Mohammad Reza Parizadeh, Mohsen Moohebati, Alireza Heidari-Bakavoli, Mahmoud Ebrahimi, Gordon A Ferns, Majid Ghayour-Mobarhan, Amir Avan
BACKGROUND: The high prevalence of cardiovascular disease (CVD) globally is attributable to an interaction between environmental and genetic factors. Gene × diet interaction studies aim to explore how a modifiable factor interacts with genetic predispositions. Here we have explored the interaction of a heat shock protein (HSP70) gene polymorphism (+1267A > G) with dietary intake and their possible association with serum C-reactive protein (CRP), an inflammatory marker, that is a major component of CVD risk...
October 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29127547/the-effects-of-magnesium-and-zinc-co-supplementation-on-biomarkers-of-inflammation-and-oxidative-stress-and-gene-expression-related-to-inflammation-in-polycystic-ovary-syndrome-a-randomized-controlled-clinical-trial
#8
Faraneh Afshar Ebrahimi, Fatemeh Foroozanfard, Esmat Aghadavod, Fereshteh Bahmani, Zatollah Asemi
Magnesium and zinc are known to exert multiple beneficial effects including anti-inflammatory and antioxidant actions. To our knowledge, data on the effects of magnesium and zinc co-supplementation on biomarkers of inflammation and oxidative stress and gene expression related to inflammation in subjects of polycystic ovary syndrome (PCOS) are scarce. This study was conducted to evaluate the effects of magnesium and zinc co-supplementation on biomarkers of inflammation and oxidative stress and gene expression related to inflammation in subjects with PCOS...
November 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29127503/relationships-between-low-grade-peripheral-inflammation-and-psychotropic-drugs-in-schizophrenia-results-from-the-national-face-sz-cohort
#9
G Fond, N Resseguier, F Schürhoff, O Godin, M Andrianarisoa, L Brunel, E Bulzacka, B Aouizerate, F Berna, D Capdevielle, I Chereau, T D'Amato, C Dubertret, J Dubreucq, C Faget, F Gabayet, C Lançon, P M Llorca, J Mallet, D Misdrahi, C Passerieux, R Rey, A Schandrin, M Urbach, P Vidailhet, L Boyer, M Leboyer
Low-grade inflammation has repeatedly been associated with schizophrenia (SZ) and in particular with cognitive impairment. Female gender, overweight and tobacco smoking have been suggested as risk factors to increase inflammation while preclinical inconsistent findings have been found regarding the association with psychotropic drugs. The aim of this study was to explore if psychotropic drugs were associated with inflammation in SZ and to determine which psychotropic drug was associated with inflammation in stable SZ subjects while considering clinical confounding factors...
November 10, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29118378/the-association-between-galectin-3-and-hs-crp-and-the-clinical-outcome-after-non-st-elevation-myocardial-infarction-with-preexisting-atrial-fibrillation
#10
Milan Pavlović, Svetlana Apostolović, Dragana Stokanović, Stefan Momčilović, Tatjana Jevtović-Stoimenov, Snezana Ćirić Zdravković, Sonja Šalinger Martinović, Nebojsa Krstić, Goran Koraćević, Danijela Djordjevic, Vladan Ćosić, Valentina N Nikolic
Increased galectin-3 plasma concentration has been linked to an unfavorable outcome in patients with heart failure or atrial fibrillation (AF). There are no published data about the prognostic utility of galectin-3 and high-sensitivity C-reactive protein (hs-CRP) for long-term clinical outcome in the Non-ST elevation acute myocardial infarction (NSTEMI) patients with preexisting AF. Thirty-two patients with the first acute NSTEMI and preexisting AF and 22 patients without preexisting AF, were prospectively followed for fifteen months...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117618/the-effects-of-flaxseed-oil-omega-3-fatty-acids-supplementation-on-metabolic-status-of-patients-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#11
Golara Mirmasoumi, Mohammad Fazilati, Fatemeh Foroozanfard, Zahra Vahedpoor, Samaneh Mahmoodi, Mohsen Taghizadeh, Nazanin Kazemi Esfeh, Maryam Mohseni, Hassan Karbassizadeh, Zatollah Asemi
Objective This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on metabolic status of patients with polycystic ovary syndrome (PCOS). Methods This randomized double-blind, placebo-controlled trial was conducted on 60 women with PCOS according to the Rotterdam criteria aged 18-40 years old. Participants were randomly assigned into two groups to receive either 1,000 mg flaxseed oil omega-3 fatty acids (n=30) or placebo (n=30) twice a day for 12 weeks. Metabolic, endocrine, inflammatory factors were quantified at baseline and after the 12-week intervention...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29115081/verification-of-current-risk-scores-for-kawasaki-disease-in-korean-children
#12
Jaeeun Shin, Heeyoung Lee, Lucy Eun
The purpose of this study was to evaluate and assess the compatibility of current risk scoring systems from Japan that were developed to predict intravenous immunoglobulin (IVIG) resistance in patients with Kawasaki disease (KD). The authors previously investigated another prediction model for patients with refractory KD in Korea. A retrospective study involving 350 patients with KD who were admitted between January 2014 and December 2015 was performed. Patients younger than 2 years were excluded for the propensity score matching in this study...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29112241/periodontal-therapy-for-the-management-of-cardiovascular-disease-in-patients-with-chronic-periodontitis
#13
REVIEW
Chunjie Li, Zongkai Lv, Zongdao Shi, Ye Zhu, Yafei Wu, Longjiang Li, Zipporah Iheozor-Ejiofor
BACKGROUND: There is an association between chronic periodontitis and cardiovascular disease (CVD). However, it is not known whether periodontal therapy could prevent or manage CVD in patients with chronic periodontitis. OBJECTIVES: The objective of this systematic review was to investigate the effects of periodontal therapy in preventing the occurrence of, and management or recurrence of, CVD in patients with chronic periodontitis. SEARCH METHODS: Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 31 August 2017), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2017, Issue 7), MEDLINE Ovid (1946 to 31 August 2017), Embase Ovid (1980 to 31 August 2017) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL EBSCO) (1937 to 31 August 2017) ...
November 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29111278/the-association-of-inflammatory-markers-and-periodontal-indexes-with-the-risk-of-coronary-heart-disease-in-chinese-patients-with-type-2-diabetes-mellitus
#14
Ling Chen, Bin Wei, Liang Xu, Yun Wu
OBJECTIVES: The present study was designed to investigate the association of four inflammatory markers and five periodontal indexes with the risk of coronary heart disease (CHD) in 131 patients with type 2 diabetes mellitus (T2DM). METHODS: All subjects were inpatients, including 63 T2DM patients with comorbid CHD ("cases") and 68 T2DM patients without CHD ("controls"). The diagnosis of CHD is based on coronary angiography. RESULTS: Peripheral blood concentrations of high sensitivity C-reactive protein (hs-CRP) (11...
October 28, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29109596/soluble-urokinase-plasminogen-activator-receptor-and-the-risk-of-coronary-artery-disease-in-young-chinese-patients
#15
Yuli Huang, Haobin Zhou, Yu Wu, You Yang, Wensheng Li, Jianhua Lu, Yunzhao Hu
Background: Soluble urokinase plasminogen activator receptor (suPAR) is a novel marker of chronic inflammation and is considered to be a risk factor for coronary artery disease (CAD) in Caucasians. This study investigated the role of suPAR in young Chinese patients with CAD. Methods: The study involved a total of 196 consecutive young (age ≤ 55 years) patients with angiographically proven CAD and 188 age-matched non-CAD individuals as controls. Traditional risk factors were evaluated using conventional assays, and levels of suPAR were measured by sandwich enzyme-linked immunosorbent assays...
2017: Disease Markers
https://www.readbyqxmd.com/read/29108529/high-sensitivity-c-reactive-protein-and-cognitive-decline-the-english-longitudinal-study-of-ageing
#16
Fanfan Zheng, Wuxiang Xie
BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) has been suggested to be involved in the process of cognitive decline. However, the results from previous studies exploring the relationship between hs-CRP concentration and cognitive decline are inconsistent. METHOD: We employed data from wave 2 (2004-2005) to wave 7 (2014-2015) of the English Longitudinal Study of Ageing. Cognitive function was assessed at baseline (wave 2) and reassessed biennially at waves 3-7...
November 7, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29102940/balneotherapy-in-psoriasis-rehabilitation
#17
Iván Péter, Anna Jagicza, Zénó Ajtay, Imre Boncz, István Kiss, Katalin Szendi, Péter Kustán, Balázs Németh
BACKGROUND/AIM: This study aimed to report a balneotherapy-based psoriasis rehabilitation protocol and assess its effectivity. PATIENTS AND METHODS: Eighty psoriatic patients who underwent a 3-week-long inward balneotherapy-based rehabilitation were enrolled. Psoriasis Area and Severity Index (PASI) score and high sensitivity C-reactive protein (CRP) were determined on admission and before discharge. RESULTS: The mean PASI score and CRP level -determined on admission and before discharge-decreased significantly after the 3-week-long rehabilitation 7...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29102157/the-ultrasound-clinical-arthritis-activity-us-clara-index-properties-of-a-new-composite-disease-activity-index-for-rheumatoid-arthritis
#18
Fausto Salaffi, Marco Di Carlo, Florenzo Iannone, Anna Laura Fedele, Oscar Massimiliano Epis, Raffaele Pellerito, Rosario Foti, Giuseppe Passiu, Leonardo Punzi, Federica Furini, Piercarlo Sarzi-Puttini, Antonio Carletto, Elisa Gremese, Giovanni Lapadula, Gianfranco Ferraccioli
OBJECTIVE: To assess validity, responsiveness and interpretability of the UltraSound-CLinical ARthritis Activity (US-CLARA) index in patients with rheumatoid arthritis (RA). METHODS: In this longitudinal study were involved RA patients starting treatment with abatacept. Subjects were followed along three visits in the first 6 months of therapy and underwent a comprehensive clinimetric evaluation. Validity was explored correlating the baseline scores and the cumulative inflammatory burden of the US-CLARA with the other composite indices applied...
September 28, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29101255/midlife-systemic-inflammation-late-life-white-matter-integrity-and-cerebral-small-vessel-disease-the-atherosclerosis-risk-in-communities-study
#19
Keenan A Walker, Melinda C Power, Ron C Hoogeveen, Aaron R Folsom, Christie M Ballantyne, David S Knopman, B Gwen Windham, Elizabeth Selvin, Clifford R Jack, Rebecca F Gottesman
BACKGROUND AND PURPOSE: It is currently unclear whether midlife systemic inflammation promotes the development of white matter (WM) abnormalities and small vessel disease in the elderly. We examined the association of midlife systemic inflammation with late-life WM hyperintensity volume, deep and periventricular WM microstructural integrity (fractional anisotropy and mean diffusivity [MD]), cerebral infarcts, and microbleeds in a biracial prospective cohort study. METHODS: Linear and logistic regression examined the relation between midlife high-sensitivity C-reactive protein (CRP)-a nonspecific marker of inflammation-and brain magnetic resonance imaging markers assessed 21 years later in the Atherosclerosis Risk in Communities Study...
November 3, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29099655/multimarker-assessment-of-diastolic-dysfunction-in-metabolic-syndrome-patients
#20
Mihaela Mocan, Florin Anton, Șoimița Suciu, Rodica Răhăian, Sorin Nicu Blaga, Anca Daniela Fărcaș
BACKGROUND: Metabolic syndrome (MetS) has been associated with left ventricular diastolic dysfunction (LVDD) with preserved systolic function. This study aims at identifying the predictive factors for LVDD in MetS patients. METHODS: The studied group comprised 72 consecutive hospitalized patients (2010-2011) diagnosed with MetS based on AHA/NHLBI/IDF 2009 definition, free of cardiovascular disease (36.11% males, age 59.19 ± 5.26 years), who underwent echocardiographic examination...
November 3, 2017: Metabolic Syndrome and related Disorders
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