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https://www.readbyqxmd.com/read/29689564/pulmonary-exposure-to-particulate-matter-pm2-5-affects-the-sensitivity-to-myocardial-ischemia-reperfusion-injury-through-farnesoid-x-receptor-induced-autophagy
#1
Fei Tong, Hua Zhang
BACKGROUND/AIMS: The purpose of this study was to investigate the effect of administering particulate matter (PM2.5) to the lungs on the sensitivity to myocardial ischemia/reperfusion injury (MI/RI) and the role of farnesoid-X-receptor (FXR)-induced autophagy in this process. METHODS: Male Sprague Dawley (SD) rats were subjected to 45 min of ischemia, and the lungs were exposed to 2.0 mg of PM2.5 in 0.3 mL of normal saline 5 min before reperfusion. After 24 h of reperfusion, the blood and myocardium were collected, and the myocardial infarct sizes, activities of serum creatine kinase (CK) and lactate dehydrogenase (LDH), and levels of serum high sensitivity C-reactive protein (hsCRP), interleukin-4 (IL-4), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), cardiac troponin T (cTnT), P-selectin and D-dimer were measured via biochemical analysis...
April 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29685109/single-marker-and-multi-marker-approaches-to-appraise-the-relationships-between-biomarkers-and-microalbuminuria-in-chinese-middle-aged-and-elderly-from-communities-a-cross-sectional-analysis
#2
Shihui Fu, Yi Guo, Zhao Zhang, Leiming Luo, Ping Ye
BACKGROUND: Analyzing the relationships between biomarkers representing distinct pathophysiologic pathways and microalbuminuria (MA) can strengthen the identifying ability for renal damage and illuminate previously unrecognized pathways for the pathogenesis of renal damage. The current analysis was to clarify the associations between biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hsCRP), homocysteine and uric acid (UA), and MA in Chinese middle-aged and elderly from communities...
April 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29683991/systemic-inflammation-immune-activation-and-impaired-lung-function-among-people-living-with-hiv-in-rural-uganda
#3
Crystal M North, Daniel Muyanja, Bernard Kakuhikire, Alexander C Tsai, Russell P Tracy, Peter W Hunt, Douglas S Kwon, David C Christiani, Samson Okello, Mark J Siedner
BACKGROUND: Although both chronic lung disease and HIV are inflammatory diseases common in sub-Saharan Africa, the relationship between systemic inflammation and lung function among people living with HIV (PLWH) in sub-Saharan Africa is not well described. METHODS: We measured lung function (using spirometry) and serum high sensitivity C-reactive protein, IL-6, sCD14 and sCD163 in 125 PLWH on stable antiretroviral therapy and 109 age and sex-similar HIV-uninfected controls in rural Uganda...
April 20, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29683202/placental-inflammation-in-pre-eclampsia-by-nod-like-receptor-protein-nlrp-3-inflammasome-activation-in-trophoblasts
#4
G S Stødle, G B Silva, L H Tangerås, L M Gierman, I Nervik, U E Dahlberg, C Sun, M H Aune, L C V Thomsen, L Bjørge, A-C Iversen
Pre-eclampsia is associated with increased levels of cholesterol and uric acid and an inflamed placenta expressing danger-sensing pattern recognition receptors (PRRs). Crystalline cholesterol and uric acid activate the PRR Nod-like receptor protein (NLRP)3 inflammasome to release interleukin (IL)-1β and result in vigorous inflammation. We aimed to characterize crystal-induced NLRP3 activation in placental inflammation and examine its role in pre-eclampsia. We confirmed that serum total cholesterol and uric acid were elevated in pre-eclamptic compared to healthy pregnancies and correlated positively to high sensitivity C-reactive protein (hsCRP) and the pre-eclampsia marker soluble fms-like tyrosine kinase-1 (sFlt-1)...
April 23, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29680881/baricitinib-in-patients-with-rheumatoid-arthritis-and-an-inadequate-response-to-conventional-disease-modifying-antirheumatic-drugs-in-united-states-and-rest-of-world-a-subset-analysis
#5
Alvin F Wells, Maria Greenwald, John D Bradley, Jahangir Alam, Vipin Arora, Cynthia E Kartman
INTRODUCTION: This article evaluates the efficacy and safety of baricitinib 4 mg versus placebo in United States including Puerto Rico (US) and rest of the world (ROW) subpopulations using data pooled from RA-BEAM and RA-BUILD, which enrolled patients with moderate-to-severe adult-onset rheumatoid arthritis (RA). METHODS: In RA-BEAM, patients with an inadequate response (IR) to methotrexate, at least one X-ray erosion, and high sensitivity C-reactive protein (hsCRP) ≥ 6 mg/L were randomized to placebo or orally administered baricitinib 4 mg daily or subcutaneously administered adalimumab 40 mg every other week...
April 21, 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29674996/association-between-thyroid-hormones-thyroid-antibodies-and-cardiometabolic-factors-in-non-obese-individuals-with-normal-thyroid-function
#6
Jia Liu, Yan Duan, Jing Fu, Guang Wang
Background: Hypothyroidism is an important risk factor for cardiovascular diseases, and autoimmune thyroiditis (AIT) is the leading cause of hypothyroidism. Recent studies showed that even AIT patients with euthyroidism still had an increased number of early atherosclerotic lesions. However, the precise mechanism is not yet known. This study aimed to investigate the association of thyroid function, thyroid autoimmunity, and cardiometabolic risk factors in non-obese AIT patients with euthyroidism...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29664028/dyslipidaemia-oxidative-stress-in-patients-of-psoriasis-emerging-cardiovascular-risk-factors
#7
Kumari Asha, Archana Singal, Suman Bala Sharma, Vinod Kumar Arora, Amitesh Aggarwal
Background & objectives: Psoriasis is a recurrent hyper-proliferative skin disease which is often associated with free radical generation, abnormal lipid metabolism and increased inflammatory secretion that induce cardiovascular risk in these patients. The present study was intended to evaluate serum lipids, lipoprotein and oxidants-antioxidants status and to establish their relationship with atherogenic risk markers [oxidized low-density lipoprotein (oxLDL) and high-sensitivity C-reactive protein (hsCRP)] in patients with psoriasis...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29663084/characterization-of-circulating-leukocytes-and-correlation-of-leukocyte-subsets-with-metabolic-parameters-1-and-5-years-after-diabetes-diagnosis
#8
Maria Apostolopoulou, Barbara Menart-Houtermans, Ruth Ruetter, Bettina Nowotny, Ulrich Gehrmann, Daniel Markgraf, Julia Szendroedi, Nanette C Schloot, Michael Roden
AIMS: Infiltration of pancreatic islets with different leukocyte subtypes likely contributes to deterioration of glycemia in diabetes mellitus. Different subsets of leukocytes have been previously associated with type 1 or type 2 diabetes. This study aimed at examining these subsets at different stages of diabetes progression and possible relationships with metabolic parameters. METHODS: A total of 206 patients, 76 with type 1 and 130 with type 2 diabetes, were studied within the first year of diabetes diagnosis...
April 16, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29629537/different-associations-of-plasma-biomarkers-in-alzheimer-s-disease-mild-cognitive-impairment-vascular-dementia-and-ischemic-stroke
#9
Jingwei Shang, Toru Yamashita, Yusuke Fukui, Dongjing Song, Xianghong Li, Yun Zhai, Yumiko Nakano, Ryuta Morihara, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe
BACKGROUND AND PURPOSE: Cognitive and cerebrovascular diseases are common in the elderly, but differences in the plasma levels and associations of plasma biomarkers in these diseases remain elusive. METHODS: The present study investigated differences in plasma fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], adiponectin, reptin, plasma markers of inflammation [high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (serum AA)], and plasma lipids [high-density lipoprotein and low-density lipoprotein (LDL)] in patients with Alzheimer's disease (AD) (n=266), mild cognitive impairment (MCI) (n=44), vascular dementia (VaD) (n=33), and ischemic stroke (IS) (n=200) in comparison to normal controls (n=130)...
January 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29624096/interleukin-6-producing-pheochromocytoma-as-a-new-reason-for-fever-of-unknown-origin-a-retrospective-study
#10
Xiangming Cheng, Mingxin Zhang, Yu Xiao, Hanzhong Li, Yushi Zhang, Zhigang Ji
OBJECTIVE: To explore the fever of unknown origin (FUO) resulted by Interleukin-6 (IL-6) producing pheochromocytoma. MATERIAL AND METHODS: Patients with pheochromocytoma were gathered from June 2014 to April 2017. The clinical characteristics of patients were recorded such as gender, age, 24hr urinary catecholamines (norepinephrine, epinephrine, dopamine), tumor size, axillary temperature (AT), white blood cells (WBC), serum IL-6 level and high sensitive C Reactive Protein (hsCRP)...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29622024/longitudinal-associations-of-long-term-exposure-to-ultrafine-particles-with-blood-pressure-and-systemic-inflammation-in-puerto-rican-adults
#11
Laura Corlin, Mark Woodin, Jaime E Hart, Matthew C Simon, David M Gute, Joanna Stowell, Katherine L Tucker, John L Durant, Doug Brugge
BACKGROUND: Few longitudinal studies have examined the association between ultrafine particulate matter (UFP, particles < 0.1 μm aerodynamic diameter) exposure and cardiovascular disease (CVD) risk factors. We used data from 791 adults participating in the longitudinal Boston Puerto Rican Health Study (Massachusetts, USA) between 2004 and 2015 to assess whether UFP exposure was associated with blood pressure and high sensitivity C-reactive protein (hsCRP, a biomarker of systemic inflammation)...
April 5, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29620449/low-lean-tissue-mass-can-be-a-predictor-of-one-year-survival-in-hemodialysis-patients
#12
Aleksandra Rymarz, Julia Gibińska, Maria Zajbt, Wiesław Piechota, Stanisław Niemczyk
PURPOSE: Nutritional status has a significant impact on the outcomes in the dialysis population. The aim of this study was to evaluate the association between body composition and a one-year survival of hemodialysis patients. METHODS: Forty-eight patients with chronic kidney disease stage V treated with hemodialysis for more than three months were included. Body composition was assessed by bioimpedance spectroscopy (Body Composition Monitor, Fresenius Medical Care)...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29618370/myeloperoxidase-level-and-inflammatory-markers-and-lipid-and-lipoprotein-parameters-in-stable-coronary-artery-disease
#13
Elżbieta Kimak, Bartosz Zięba, Dariusz Duma, Janusz Solski
BACKGROUND: Myeloperoxidase (MPO) impairing endothelial functions. We investigated whether increasing concentration of myeloperoxidase (MPO) and inflammatory markers induce progression and incident acute coronary syndrome (ACS) in stable coronary artery disease (SCAD) patients. Therefore, the concentration of MPO, lipids, lipoproteins (apo(apolipoprotein) AI, apoB, lipoprotein associated phospholipase A2 (LpPLA2) level), inflammatory markers (high sensitivity C-reactive protein (hsCRP), tumor necrosis factor-α (TNF-α), interleukine-6 (IL-6) concentration) were examined...
April 4, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29615976/higher-prevalence-of-low-t3-syndrome-in-patients-with-chronic-fatigue-syndrome-a-case-control-study
#14
Begoña Ruiz-Núñez, Rabab Tarasse, Emar F Vogelaar, D A Janneke Dijck-Brouwer, Frits A J Muskiet
Chronic fatigue syndrome (CFS) is a heterogeneous disease with unknown cause(s). CFS symptoms resemble a hypothyroid state, possibly secondary to chronic (low-grade) (metabolic) inflammation. We studied 98 CFS patients (21-69 years, 21 males) and 99 age- and sex-matched controls (19-65 years, 23 males). We measured parameters of thyroid function, (metabolic) inflammation, gut wall integrity and nutrients influencing thyroid function and/or inflammation. Most remarkably, CFS patients exhibited similar thyrotropin, but lower free triiodothyronine (FT3) (difference of medians 0...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29615435/association-of-biomarker-clusters-with-cardiac-phenotypes-and-mortality-in-patients-with-hiv-infection
#15
Rebecca Scherzer, Sanjiv J Shah, Eric Secemsky, Javed Butler, Carl Grunfeld, Michael G Shlipak, Priscilla Y Hsue
BACKGROUND: Although individual cardiac biomarkers are associated with heart failure risk and all-cause mortality in HIV-infected individuals, their combined use for prediction has not been well studied. METHODS AND RESULTS: Unsupervised k-means cluster analysis was performed blinded to the study outcomes in 332 HIV-infected participants on 8 biomarkers: ST2, NT-proBNP (N-terminal pro-B-type natriuretic peptide), hsCRP (high-sensitivity C-reactive protein), GDF-15 (growth differentiation factor 15), cystatin C, IL-6 (interleukin-6), D-dimer, and troponin...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29604599/garlic-extract-favorably-modifies-markers-of-endothelial-function-in-obese-patients-randomized-double-blind-placebo-controlled-nutritional-intervention
#16
Monika Szulińska, Matylda Kręgielska-Narożna, Joanna Świątek, Paulina Styś, Barbara Kuźnar-Kamińska, Hieronim Jakubowski, Jarosław Walkowiak, Paweł Bogdański
OBJECTIVE: Garlic exerts a range of effects relevant to human health. However, its influence on the endothelium in obese individuals remains unknown. We aimed to determine the effects of garlic extract (GE) on arterial stiffness and markers of endothelial function. METHODS: Ninety-two subjects were enrolled in this study. The participants were randomly assigned to receive 400 mg of GE or placebo daily for 3 months. The arterial stiffness index (SI) and markers of endothelial function such as high-sensitivity C-reactive protein (hsCRP), cholesterol (total, LDL, HDL), triglycerides, and plasminogen activator inhibitor 1 (PAI-1), as well as total antioxidant status (TAS) were quantified at baseline and the end of study...
March 28, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29593897/serum-presepsin-levels-are-not-elevated-in-patients-with-controlled-hypertension
#17
Ismail Biyik, Fatma Nihan Turhan Caglar, Nilgun Isiksacan, Nursel Kocamaz, Pınar Kasapoglu, Asuman Gedikbasi, Faruk Akturk
Introduction: Hypertension (HT) is a common serious condition associated with cardiovascular morbidity and mortality. The pathogenesis of HT is multifactorial and has been widely investigated. Besides the vascular, hormonal, and neurological factors, inflammation plays a crucial role in HT. Many inflammatory markers such as C-reactive protein, cytokines, and adhesion molecules have been studied in HT, which supported the role of inflammation in the pathogenesis of HT. Presepsin (PSP) is a novel biomarker of inflammation...
2018: International Journal of Hypertension
https://www.readbyqxmd.com/read/29593803/can-we-define-migraine-patients-with-blood-high-sensitivity-c-reactive-protein-and-galectin-3-levels-in-the-emergency-department
#18
Mehtap Gürger, Metin Atescelik, Mustafa Yilmaz, Mustafa Yildiz, Hatice Kalayci, Mehmet Ali Kobat, Caner Fevzi Demir
Introduction: Migraine, the most widespread cause of headache in young adults, is a frequent reason for presentation to emergency departments. The aim of this study was to determine the diagnostic value of serum galectin-3 and high-sensitivity C-reactive protein (hsCRP) levels in migraine patients. Material and methods: Serum galectin-3 and hsCRP levels were measured using enzyme-linked immunosorbent assay in 70 migraine patients and 70 healthy control subjects...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29590229/association-of-oxytocin-with-glucose-intolerance-and-inflammation-biomarkers-in-metabolic-syndrome-patients-with-and-without-prediabetes
#19
Amal Akour, Violet Kasabri, Nailya Bulatova, Suha Al Muhaissen, Randa Naffa, Hiba Fahmawi, Munther Momani, Ayman Zayed, Yasser Bustanji
OBJECTIVES: The aim of this study was to explore the differences in OXT levels in metabolic syndrome (MetS) subjects, newly diagnosed type 2 diabetes mellitus (T2D), and prediabetes subjects vs. MetS subjects without glucose intolerance (non-diabetic MetS). It was also intended to determine the relationship between plasma OXT levels and inflammatory markers in those subjects. METHODS: Along with 45 lean and normoglycemic controls, a total of 190 MetS subjects (61 men, 129 women) were enrolled...
2018: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/29590199/the-urine-albumin-creatinine-ratio-is-a-predictor-for-incident-long-term-care-in-a-general-population
#20
Shuko Takahashi, Fumitaka Tanaka, Yuki Yonekura, Kozo Tanno, Masaki Ohsawa, Kiyomi Sakata, Makoto Koshiyama, Akira Okayama, Motoyuki Nakamura
BACKGROUND: Several types of cardiovascular diseases (CVDs) impair the physical and mental status. The purpose of this study was to assess the predictive ability of several cardiovascular biomarkers for identifying the incidence of disability as future recipients of public long-term care (LTC) service. METHODS: The subjects of this study were community-dwelling elderly individuals ≥ 65 years of age without a history of CVD (n = 5,755; mean age, 71 years). The endpoint of this study was official certification as a recipient of LTC...
2018: PloS One
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