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https://www.readbyqxmd.com/read/28222921/relationships-between-left-ventricular-structure-and-function-according-to-cardiac-mri-and-cardiac-biomarkers-in-end-stage-renal-disease
#1
Bryan A Ross, Ron Wald, Marc B Goldstein, Darren A Yuen, Jonathon Leipsic, Mercedeh Kiaii, Andrea Rathe, Djeven P Deva, Anish Kirpalani, Olugbenga O Bello, John J Graham, Howard Leong-Poi, Kim A Connelly, Andrew T Yan
BACKGROUND: We sought to assess the relationships between left ventricular (LV) remodelling and the mechanical and uremic stressors in hemodialysis patients. METHODS: In this prospective 2-centre cohort study, 67 prevalent hemodialysis patients were followed for 1 year. Data on routine bloodwork and predialysis blood pressure (BP) measurements were collected over a 12-week period. LV end-diastolic volume (LVEDV) and LV mass (LVM) were measured using cardiac magnetic resonance imaging and indexed...
December 3, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28222033/non-hdl-cholesterol-and-c-reactive-protein-in-children-and-adolescents-with-type-1-diabetes
#2
María Mercedes Prado, Teresita Carrizo, Adela Victoria Abregú, Tomás Meroño
BACKGROUND: To what extent high sensitivity C-reactive protein (hsCRP) is associated with known cardiovascular risk factors in children with type 1 diabetes (T1D) has not been fully explored. METHODS: Forty-two T1D children (age: 12+/-1 years) without hypertension, retinopathy, hypothyroidism, albuminuria or other endocrine diseases and 20 controls were studied. Out of the 42 T1D patients studied 57% were prepubertal or early pubertal (Tanner I/II), 38% were pubertal (Tanner III/IV) and 5% post-pubertal (Tanner V)...
February 21, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28212629/cardiometabolic-risk-in-a-population-of-older-adults-with-multiple-co-morbidities-in-rural-south-africa-the-haalsi-health-and-aging-in-africa-longitudinal-studies-of-indepth-communities-study
#3
Thomas A Gaziano, Shafika Abrahams-Gessel, F Xavier Gomez-Olive, Alisha Wade, Nigel J Crowther, Sartaj Alam, Jennifer Manne-Goehler, Chodziwadziwa W Kabudula, Ryan Wagner, Julia Rohr, Livia Montana, Kathleen Kahn, Till W Bärnighausen, Lisa F Berkman, Stephen Tollman
BACKGROUND: A consequence of the widespread uptake of anti-retroviral therapy (ART) is that the older South African population will experience an increase in life expectancy, increasing their risk for cardiometabolic diseases (CMD), and its risk factors. The long-term interactions between HIV infection, treatment, and CMD remain to be elucidated in the African population. The HAALSI cohort was established to investigate the impact of these interactions on CMD morbidity and mortality among middle-aged and older adults...
February 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28207497/concurrent-presence-of-inflammation-and-obstructive-sleep-apnea-exacerbates-the-risk-of-metabolic-syndrome-a-koges-6-year-follow-up-study
#4
Jinkwan Kim, Dae Wui Yoon, Seung Ku Lee, Seunggwan Lee, Kyung-Mee Choi, Thomas J Robert, Chol Shin
Obstructive sleep apnea (OSA) leads to multiple end-organ morbidities that are mediated by the cumulative burden of oxidative stress and inflammation. Both OSA and inflammation play key roles in increased risk of cardiovascular disease (CVD). Thus, we hypothesized that the combination of inflammation and OSA could accelerate the development of metabolic syndrome (MetS) in a large cohort study.A total of 1835 participants were randomly selected from the ongoing Korean Genome and Epidemiology Study for the years between 2007 and 2015...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28190687/short-term-effects-of-particle-size-fractions-on-circulating-biomarkers-of-inflammation-in-a-panel-of-elderly-subjects-and-healthy-young-adults
#5
Mohammad Sadegh Hassanvand, Kazem Naddafi, Homa Kashani, Sasan Faridi, Nino Kunzli, Ramin Nabizadeh, Fatemeh Momeniha, Akbar Gholampour, Mohammad Arhami, Ahad Zare, Zahra Pourpak, Mohammad Hoseini, Masud Yunesian
Systemic inflammation biomarkers have been associated with risk of cardiovascular morbidity and mortality. We aimed to clarify associations of acute exposure to particulate matter (PM10 (PM < 10 μm), PM2.5-10 (PM 2.5-10 μm), PM2.5 (PM < 2.5 μm), PM1-2.5 (PM 1-2.5 μm), and PM1 (PM < 1 μm)) with systemic inflammation using panels of elderly subjects and healthy young adults. We followed a panel of 44 nonsmoking elderly subjects living in a retirement home and a panel of 40 healthy young adults living in a school dormitory in Tehran city, Iran from May 2012 to May 2013...
February 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28182038/study-of-anemia-in-nondialysis-dependent-chronic-kidney-disease-with-special-reference-to-serum-hepcidin
#6
H Goyal, S Mohanty, M Sharma, A Rani
We studied the role of serum hepcidin in anemia of chronic kidney disease (CKD) in a hospital-based cross-sectional study. Serum hepcidin, ferritin, and high-sensitivity C-reactive protein (hsCRP) levels were evaluated in patients of CKD. Hepcidin levels were increased in patients as compared to healthy adults. Hepcidin levels increased as CKD progressed through stage 3-5 (P trend = 0.015) but did not correlate with estimated glomerular filtration rate. Hepcidin correlated positively with ferritin (P < 0...
January 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28174109/increased-ratio-of-high-sensitivity-c-reactive-protein-to-interleukin-10-as-a-potential-peripheral-biomarker-of-schizophrenia-and-aggression
#7
Qinting Zhang, Wu Hong, Haozhe Li, Fanglan Peng, Fan Wang, Ningning Li, Hui Xiang, Zongfeng Zhang, Yousong Su, Yueqi Huang, Shengyu Zhang, Guoqin Zhao, Rubai Zhou, Ling Mao, Zhiguang Lin, Weixiong Cai, Yiru Fang, Bin Xie, Min Zhao
BACKGROUND: Many studies have indicated that immune dysfunction might be involved in the physiopathology of schizophrenia and aggression. This study aimed to investigate the correlation between high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-10 and clinical characteristics, especially aggression, and to explore the potential role of hsCRP and IL-10 as plasma biomarkers of schizophrenia. METHODS: Forty-one patients with schizophrenia and forty healthy individuals were enrolled...
February 4, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28164513/baseline-red-blood-cell-distribution-width-correlates-with-disease-activity-and-therapeutic-outcomes-in-patients-with-systemic-lupus-erythematosus-irrespective-of-anemia-status
#8
Xing-Li Zou, Xiao-Jing Lin, Xun Ni, Jing Wang, Wen Liu, Jin Wei
BACKGROUND: Red blood cell distribution width (RDW) has been recently found to reflect systemic inflammation in addition to anisocytosis, and its value for assessing disease activity of systemic lupus erythematosus (SLE) has been addressed in two studies, but its correlation with therapeutic outcomes and disease flare has not been evaluated. METHODS: One hundred and ninety-six newly diagnosed patients with SLE (all-SLE), including 105 non-anemic patients (na-SLE) and 91 patients with anemia (a-SLE) were prospectively studied...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28163961/the-adjuvant-use-of-calcium-fructoborate-and-borax-with-etanercept-in-patients-with-rheumatoid-arthritis-pilot-study
#9
Saad Abdulrahman Hussain, Sattar Jabir Abood, Faiq Isho Gorial
OBJECTIVE: This study was designed to evaluate the effects calcium fructoborate (CFB) and sodium tetraborate (NTB) as supplements in Iraqi patients with active rheumatoid arthritis (RA) maintained on etanercept. MATERIALS AND METHODS: A double-blind randomized placebo-controlled clinical trial with 60 days treatment period was carried out at Baghdad Teaching Hospital, Medical city, Baghdad, Iraq. Eighty RA patients were randomized into three groups to receive either 220 mg/day CFB, 55 mg/day NTB in capsule dosage form (equivalent to 6 mg elemental Boron), or placebo formula once daily...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28160438/metabolically-healthy-obesity-and-incident-chronic-kidney-disease-the-role-of-systemic-inflammation-in-a-prospective-study
#10
Lin Lin, Kui Peng, Rui Du, Xiaolin Huang, Jieli Lu, Yu Xu, Min Xu, Yuhong Chen, Yufang Bi, Weiqing Wang
OBJECTIVE: To investigate the association between the metabolically healthy obesity (MHO) phenotype and incident chronic kidney disease (CKD) in a Chinese population and whether systemic inflammation affects this association. METHODS: A cohort study was performed with 2,491 Chinese adults. Body mass index ≥ 25.0 kg/m(2) was defined as obesity. CKD was defined as estimated glomerular filtration rate < 60 mL/min per 1.73 m(2) or urinary albumin-to-creatinine ratio ≥ 30 mg/g...
February 3, 2017: Obesity
https://www.readbyqxmd.com/read/28154166/prognostic-significance-of-plasma-high-sensitivity-c-reactive-protein-in-patients-with-hypertrophic-cardiomyopathy
#11
Ling Zhu, Yubao Zou, Yilu Wang, Xiaoliang Luo, Kai Sun, Hu Wang, Lei Jia, Yan Liu, Juan Zou, Zuyi Yuan, Rutai Hui, Lianming Kang, Lei Song, Jizheng Wang
BACKGROUND: Elevated high-sensitivity C-reactive protein (hsCRP) has been associated with increased risks of adverse outcomes of various cardiovascular diseases. The relationship between hsCRP and the prognosis of hypertrophic cardiomyopathy remains to be evaluated. METHODS AND RESULTS: The study used an observational cohort methodology. A total of 490 patients were enrolled in the Fuwai Hospital from 2001 to 2011 and were followed for 3.7±2.0 years. According to the risk category of hsCRP, subjects in the high hsCRP group (>3...
February 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28153935/association-of-tnf-receptor-2-and-crp-with-gfr-decline-in-the-general-nondiabetic-population
#12
Jørgen Schei, Vidar Tor Nyborg Stefansson, Bjørn Odvar Eriksen, Trond Geir Jenssen, Marit Dahl Solbu, Tom Wilsgaard, Toralf Melsom
BACKGROUND AND OBJECTIVES: Higher levels of inflammatory markers have been associated with renal outcomes in diabetic populations. We investigated whether soluble TNF receptor 2 (TNFR2) and high-sensitivity C-reactive protein (hsCRP) were associated with the age-related GFR decline in a nondiabetic population using measured GFR (mGFR). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A representative sample of 1590 middle-aged people from the general population without prevalent kidney disease, diabetes, or cardiovascular disease were enrolled in the Renal Iohexol-Clearance Survey in Tromsø 6 (RENIS-T6) between 2007 and 2009...
February 2, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28153875/prognostic-impacts-of-plasma-levels-of-cyclophilin-a-in-patients-with-coronary-artery-disease
#13
Tomohiro Ohtsuki, Kimio Satoh, Junichi Omura, Nobuhiro Kikuchi, Taijyu Satoh, Ryo Kurosawa, Masamichi Nogi, Shinichiro Sunamura, Nobuhiro Yaoita, Tatsuo Aoki, Shunsuke Tatebe, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa
OBJECTIVE: Cyclophilin A (CyPA) is secreted from vascular smooth muscle cells, inflammatory cells, and activated platelets in response to oxidative stress. We have recently demonstrated that plasma CyPA level is a novel biomarker for diagnosing coronary artery disease. However, it remains to be elucidated whether plasma CyPA levels also have a prognostic impact in such patients. APPROACH AND RESULTS: In 511 consecutive patients undergoing diagnostic coronary angiography, we measured the plasma levels of CyPA, high-sensitivity C-reactive protein (hsCRP), and brain natriuretic peptide and evaluated their prognostic impacts during the follow-up (42 months, interquartile range: 25-55 months)...
February 2, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28148953/retinopathy-signs-improved-prediction-and-reclassification-of-cardiovascular-disease-risk-in-diabetes-a-prospective-cohort-study
#14
Henrietta Ho, Carol Y Cheung, Charumathi Sabanayagam, Wanfen Yip, Mohammad Kamran Ikram, Peng Guan Ong, Paul Mitchell, Khuan Yew Chow, Ching Yu Cheng, E Shyong Tai, Tien Yin Wong
CVD risk prediction in diabetics is imperfect, as risk models are derived mainly from the general population. We investigate whether the addition of retinopathy and retinal vascular caliber improve CVD prediction beyond established risk factors in persons with diabetes. We recruited participants from the Singapore Malay Eye Study (SiMES, 2004-2006) and Singapore Prospective Study Program (SP2, 2004-2007), diagnosed with diabetes but no known history of CVD at baseline. Retinopathy and retinal vascular (arteriolar and venular) caliber measurements were added to risk prediction models derived from Cox regression model that included established CVD risk factors and serum biomarkers in SiMES, and validated this internally and externally in SP2...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144255/vitamin-d-status-and-circulating-biomarkers-of-endothelial-dysfunction-and-inflammation-in-non-diabetic-obese-individuals-a-pilot-study
#15
Branislava Ilinčić, Edita Stokić, Zoran Stošić, Nevena Eremić Kojić, Niki Katsiki, Dimitri P Mikhailidis, Esma R Isenovic
INTRODUCTION: Obesity and inadequate vitamin D status are associated with endothelial dysfunction and cardiovascular disease. We evaluated the associations between vitamin D status (i.e. serum levels of 25-hydroxyvitamin D (25(OH)D)), biomarkers of endothelial dysfunction (i.e. serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin)), inflammatory markers (i.e. high-sensitivity C-reactive protein (hsCRP) and fibrinogen) and cardiometabolic risk factors...
February 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28120261/atorvastatin-decreased-circulating-rantes-levels-in-impaired-glucose-tolerance-patients-with-hypercholesterolemia-an-interventional-study
#16
Xiaomeng Feng, Xia Gao, Yumei Jia, Heng Zhang, Yuan Xu
INTRODUCTION: Impaired glucose tolerance (IGT) is the major cause of the development of both type 2 diabetes and atherosclerosis. Regulated upon activation, normal T cells expressed and secreted (RANTES), a proinflammatory chemokine, is associated with atherosclerosis. We investigated the effect of atorvastatin on circulating RANTES in IGT patients with hypercholesterolemia. METHODS: This study evaluated cross-sectional and interventional studies of 32 IGT patients with hypercholesterolemia (group A) and 32 controls (group B)...
January 24, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28119302/cognitive-functioning-in-coronary-artery-disease-patients-associations-with-thyroid-hormones-n-terminal-pro-b-type-natriuretic-peptide-and-high-sensitivity-c-reactive-protein
#17
Julius Burkauskas, Adomas Bunevicius, Julija Brozaitiene, Julius Neverauskas, Peter Lang, Robert Duwors, Narseta Mickuviene, Robertas Bunevicius
OBJECTIVE: To determine whether biomarkers of health such as serum levels of free triiodothyronine (fT3), total triiodothyronine (TT3), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hsCRP) impact the cognitive functioning of coronary artery disease (CAD) patients. METHOD: About 278 patients were evaluated for socio-demographic and clinical risk factors as well as fT3, TT3, NT-proBNP, and hsCRP serum levels. Cognitive functioning measures included the Mini-Mental State Examination, Digit Span Test, Digit Symbol Substitution Test (DSST), and Trail Making Test A (TMTA)...
January 23, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28107228/contribution-of-oxidative-stress-to-non-aids-events-in-hiv-infected-patients
#18
Mar Masiá, Sergio Padilla, Marta Fernández, Xavier Barber, Santiago Moreno, José Antonio Iribarren, Joaquín Portilla, Alejandro Peña, Francesc Vidal, Félix Gutiérrez
OBJECTIVE: Recognition of potentially modifiable mechanisms implicated in the pathogenesis of non-AIDS events (NAEs) might help improve outcomes of HIV-infected individuals. HIV infection has been associated with increased oxidative stress. We assessed the association between F2-isoprostanes and serious NAEs, and whether they improve the predictive performance of inflammation and coagulation biomarkers. METHODS: Prospective multicenter cohort. Individuals who had an incident serious NAE and two sex and age matched participants with no events were selected...
January 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28093573/impact-of-lifestyle-intervention-for-obese-women-during-pregnancy-on-maternal-metabolic-and-inflammatory-markers
#19
K M Renault, E M Carlsen, S Hædersdal, L Nilas, N J Secher, J Eugen-Olsen, D Cortes, S F Olsen, T I Halldorsson, K Nørgaard
BACKGROUND: Offspring of obese mothers have increased risk of developing obesity and related short and long-term disease. The cause is multifactorial and may partly be explained by the unfavorable intrauterine environment. Intervention during pregnancy leading to a healthier lifestyle among obese may alter this. OBJECTIVE: To assess the effect of lifestyle intervention on markers of maternal metabolism and inflammation in 'the TOP (Treatment of Obese Pregnant Women)-study', a randomized controlled trial...
January 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28077069/a-pilot-study-of-brisk-walking-in-sedentary-combination-antiretroviral-treatement-cart-treated-patients-benefit-on-soluble-and-cell-inflammatory-markers
#20
Matteo Bonato, Laura Galli, Laura Passeri, Valeria Longo, Gaspare Pavei, Simona Bossolasco, Cecilia Bertocchi, Massimo Cernuschi, Giuseppe Balconi, Giampiero Merati, Adriano Lazzarin, Antonio La Torre, Paola Cinque
BACKGROUND: Chronic HIV infection is associated with low-level inflammation and increased risk of chronic diseases and mortality. The objective was to assess the effects of moderate intensity exercise on metabolic and inflammatory markers in HIV-infected treated persons. METHODS: This was a pilot study enrolling cART-treated, sedentary persons with metabolic complications in a 12-week protocol, consisting of three sessions per week of 60 min brisk walking with (strength-walk group) or without (walk group) 30 min circuit-training...
January 11, 2017: BMC Infectious Diseases
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