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https://www.readbyqxmd.com/read/27916142/alcohol-sensitivity-alcohol-use-and-high-sensitivity-c-reactive-protein-in-older-chinese-men-the-guangzhou-biobank-cohort-study
#1
Shao Jun Xu, Chao Qiang Jiang, Wei Sen Zhang, Kar Keung Cheng, Catherine Mary Schooling, Lin Xu, Bin Liu, Ya Li Jin, Kin Bong Hubert Lam, Tai Hing Lam
Compared to other ethnic groups Asians are more likely to be sensitive to alcohol, due to polymorphisms of alcohol-metabolizing enzymes. Although previous studies have found positive association between regular alcohol use and high-sensitivity C-reactive protein (HsCRP), whether this association is modified by alcohol sensitivity has not been clarified. We therefore sought to examined this potential effect modification in a cross-sectional community sample with high prevalence of alcohol sensitivity, using data from 2903 men aged ≥50years recruited during phase 1 of the Guangzhou Biobank Cohort Study...
December 2016: Alcohol
https://www.readbyqxmd.com/read/27916077/-intestinal-barrier-dysfunction-and-its-related-factors-in-patients-with-sepsis
#2
W Liu, X H Wang, X J Yang, X Y Zhang, W J Qi
Objective: To investigate the relationship between related factors of intestinal barrier dysfunction in patients with sepsis or septic shock and severity of the condition. Methods: A prospective observational study was conducted in 31 sepsis patients, 28 septic shock patients, and 21 postoperative patients without sepsis (control group) who were admitted to intensive care unit (ICU) of General Hospital of Ningxia Medical University between November 2015 and June 2016. Blood samples were collected from the patients within 24 hours following admission to ICU...
November 29, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27914132/associations-between-soluble-receptor-for-advanced-glycation-end-products-srage-and-s100a12-en-rage-with-mortality-in-long-term-hemodialysis-patients
#3
Eul Sik Jung, Wookyung Chung, Ae Jin Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Ji Yong Jung
Hemodialysis (HD) patients experience vascular calcification, ultimately leading to high mortality rates. Previously, we reported associations between soluble receptor for advanced glycation end products (sRAGEs) and extracellular newly identified RAGE-binding protein S100A12 (EN-RAGE) and vascular calcification. Here, we extended our observations, investigating whether these biomarkers may be useful for predicting cardiovascular morbidity and mortality in these subjects. Thus, we evaluated the relationship between sRAGE and S100A12 and mortality in long-term HD patients...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27902713/association-of-n-linked-glycoprotein-acetyls-and-colorectal-cancer-incidence-and-mortality
#4
Paulette D Chandler, Akintunde O Akinkuolie, Deirdre K Tobias, Patrick R Lawler, Chungying Li, M Vinayaga Moorthy, Lu Wang, Daniel A Duprez, David R Jacobs, Robert J Glynn, James Otvos, Margery A Connelly, Wendy S Post, Paul M Ridker, JoAnn E Manson, Julie E Buring, I-Min Lee, Samia Mora
BACKGROUND: Acute phase proteins highlight the dynamic interaction between inflammation and oncogenesis. GlycA, a novel nuclear magnetic resonance (NMR) inflammatory marker that identifies primarily circulating N-acetyl glycan groups attached to acute phase proteins, may be a future CRC risk biomarker. METHODS: We examined the association between GlycA and incident CRC and mortality in two prospective cohorts (N = 34,320); Discovery cohort: 27,495 participants from Women's Health Study (WHS); Replication cohort: 6,784 participants from Multi-Ethnic Study of Atherosclerosis (MESA)...
2016: PloS One
https://www.readbyqxmd.com/read/27892896/c-reactive-protein-as-a-diagnostic-and-prognostic-factor-in-inflammatory-bowel-diseases
#5
Dorota Mańkowska-Wierzbicka, Jacek Karczewski, Barbara Poniedziałek, Małgorzata Grzymisławska, Rafał Staszewski, Aleksandra Królczyk, Agnieszka Dobrowolska, Marian Grzymisławski
AIM: The study aimed to evaluate high-sensitivity CRP (hsCRP) as a diagnostic and predictive marker in patients with inflammatory bowel disease (IBD). MATERIAL/METHODS: Medical history of 106 patients with IBD revealed hsCRP concentrations at diagnosis and during the follow-up period. RESULTS: The study showed that the majority of investigated patients had elevated hsCRP concentrations at diagnosis, although the mean concentration was much higher in the group of patients with Crohn's disease (CD) than the group with ulcerative colitis (UC) (P<0...
November 7, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27882931/plasma-sfrp5-and-adiponectin-levels-in-relation-to-blood-pressure-among-obese-children
#6
C Yin, H Chu, H Li, Y Xiao
The aim was to clarify the associations of five adipocytokines: Sfrp5, Wnt5a, adiponectin, chemerin and high-sensitivity C-reactive protein (hsCRP) with blood pressure (BP), and to examine whether BP can be influenced by changes in these adipocytokines in obese children after a 6-month lifestyle intervention. We conducted a cross-sectional study in 263 obese children and performed a 6-month lifestyle intervention in a subgroup of 89 obese children with hypertension. Anthropometric data, adiponectin, chemerin, Sfrp5 and Wnt5a were assessed at baseline and after 6-month lifestyle intervention...
November 24, 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/27870908/n-terminal-pro-b-type-natriuretic-peptide-as-a-biomarker-for-loss-of-muscle-mass-in-prevalent-hemodialysis-patients
#7
Misa Ikeda, Hirokazu Honda, Keiko Takahashi, Kanji Shishido, Takanori Shibata
Protein-energy wasting (PEW) is common in hemodialysis (HD) patients. A recent study demonstrated that a high level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) may be associated with PEW in those patients. This prospective study aimed to assess the association of NT-proBNP with body composition and muscle loss. A cohort of prevalent HD patients (n = 238) was examined. Blood samples were obtained at baseline to measure high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), adiponectin and NT-proBNP...
2016: PloS One
https://www.readbyqxmd.com/read/27865093/maternal-endothelial-damage-as-a-disorder-shared-by-early-preeclampsia-late-preeclampsia-and-intrauterine-growth-restriction
#8
Sebastian Kwiatkowski, Barbara Dołegowska, Ewa Kwiatkowska, Rafał Rzepka, Natalia Marczuk, Beata Loj, Andrzej Torbè
INTRODUCTION: Preeclampsia (PE) and intrauterine growth restriction (IUGR) are separate disease entities that have frequently been reported as sharing the same pathogenesis. In both of them, angiogenesis disorders and generalized endothelial damage with an accompanying inflammation are the dominant symptoms. In this study, we attempted to prove that both these processes demonstrate the same profile in early PE, late PE and IUGR patients, while the only difference is in the degree of exacerbation of the lesions...
November 19, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27864821/effect-of-alterations-in-apoptotic-pathway-on-development-of-metabolic-syndrome-in-patients-with-psoriasis-vulgaris
#9
S Korkmaz, H Korkmaz
OBJECTIVES: The purpose of this study is to evaluate the role of changes in gene expression of apoptosis activators (BAX, cytocrome-c [cyt-c], and caspase-3) and apoptosis inhibitors (BCL2, survivin, cyclin D1 [CCND1], SOD, catalase 3 [CAT], glutathione synthetase [GS], heat shock protein [HSP]27, HSP60, HSP70, and HSP90) on the development of metabolic syndrome (MetS) in patients with psoriasis vulgarins. METHODS: Fifty patients with psoriasis were enrolled in the study, 25 of whom had MetS...
November 18, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27859847/the-association-of-low-birth-weight-with-serum-c-reactive-protein-in-3-year-old-children-living-in-cuba-a-population-based-prospective-study
#10
Silvia Josefina Venero-Fernández, Hermes Fundora-Hernández, Lourdes Batista-Gutierrez, Ramón Suárez-Medina, Esperanza de la C Mora-Faife, Gladys García-García, Ileana Del Valle-Infante, Liem Gómez-Marrero, John Britton, Andrew W Fogarty
OBJECTIVE: Low birthweight is associated with a decreased risk of childhood leukemia and an increased risk of both cardiovascular disease and all-cause mortality in adult life. Possible biological mediators include systemic innate immunity and inflammation. We tested the hypothesis that birthweight was inversely associated with serum high sensitivity C reactive protein assay (hsCRP), a measure of both innate immunity and systemic inflammation. METHODS: Data on birthweight and current anthropometric measures along with a range of exposures were collected at 1 and 3 years of age in a population-based cohort study of young children living in Havana, Cuba...
November 18, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27858577/long-term-endurance-training-increases-serum-cathepsin-s-and-decreases-il-6-and-hscrp-levels
#11
Michael Sponder, Ioana-Alexandra Campean, Michael Emich, Monika Fritzer-Szekeres, Brigitte Litschauer, Jutta Bergler-Klein, Senta Graf, Jeanette Strametz-Juranek
Cathepsin S (CS) was shown to play a key role in cancer progression, atherosclerosis, heart valve disease, insulin resistance and diabetes mellitus. The present prospective study aimed to investigate the influence of sports on CS, interleukin-6 (Il-6) and high-sensitivity C-reactive protein (hsCRP) levels. Ninety-eight of 109 participants completed the study. Ergometries were performed at baseline and after 8 months to evaluate/quantify the performance gain. Blood samples were taken at baseline and every 2 months...
November 18, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27856456/inflammatory-obesity-phenotypes-gender-effects-and-subclinical-atherosclerosis-in-african-americans-the-jackson-heart-study
#12
Albert Lin, Mary E Lacy, Charles Eaton, Adolfo Correa, Wen-Chih Wu
OBJECTIVE: Reasons for variations in atherosclerotic burden among individuals with similar levels of obesity are poorly understood, especially in African Americans. This study examines whether high-sensitivity C-reactive protein (hsCRP) is useful for discriminating between benign and high-risk obesity phenotypes for subclinical atherosclerosis in African Americans. APPROACH AND RESULTS: Participants from the Jackson Heart Study (n=4682) were stratified into 4 phenotypes based on the presence of National Heart and Lung and Blood Institute definition of obesity or obesity-equivalent (body mass index ≥30 or body mass index 25-30 with waist circumference >102 cm in men and >88 cm in women) and inflammation by hsCRP ≥2 mg/L...
December 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27843074/testosterone-threshold-for-increased-cardiovascular-risk-in-middle-aged-and-elderly-men-a-locally-weighted-regression-analysis
#13
Pin-Wen Liao, Chia-Chang Wu, Kuan-Chou Chen, Fu-Shan Jaw, Hong-Jeng Yu, Shih-Ping Liu, Chen-Hsun Ho
INTRODUCTION: Although testosterone deficiency has a well-known association with increased risk of cardiovascular disease (CVD), the threshold remains to be determined. AIM: To investigate whether there is a discriminatory testosterone level below which the CVD risk increases. METHODS: The study included 876 men 45 to 74 years old who underwent a general health checkup. The Framingham Risk Score was used to estimate the 10-year CVD risk; a high-sensitivity C-reactive protein (hsCRP) level of at least 1 mg/L was considered an indicator of increased CVD risk...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27834418/effect-of-periodontitis-on-bone-mineral-density-in-postmenopausal-women-a-non-randomized-interventional-study
#14
Aastha Baldodia, Rajinder Kumar Sharma, Shikha Tewari, Satish Chander Narula
OBJECTIVE: Chronic periodontitis (CP) is associated with increased systemic inflammation and osteoporosis. Pro-inflammatory cytokines, implicated in systemic bone loss, are also associated with periodontitis. The impact of control of systemic inflammation by scaling and root planing (SRP) on bone mineral density (BMD) in postmenopausal (PM) osteopenic women with CP was investigated in this study. METHOD AND MATERIALS: Sixty-eight PM osteopenic women with CP were included...
November 10, 2016: Quintessence International
https://www.readbyqxmd.com/read/27833859/associations-of-25-hydroxyvitamin-d-with-markers-of-inflammation-insulin-resistance-and-obesity-in-black-and-white-community-dwelling-adults
#15
Jennifer L Jackson, Suzanne E Judd, Bhupesh Panwar, Virginia J Howard, Virginia G Wadley, Nancy S Jenny, Orlando M Gutiérrez
AIMS: Vitamin D is a fat-soluble vitamin classically known for its role in calcium absorption and bone health. Growing evidence indicates that vitamin D deficiency may be associated with inflammation, insulin resistance, and obesity. However, prior studies examining the association of vitamin D with metabolic risk factors had relatively low representation of individuals of black race, limiting their ability to characterize associations of vitamin D and parameters of metabolic health in black vs...
September 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/27831642/plasma-pentraxin-3-is-associated-with-endothelial-dysfunction-in-non-alcoholic-fatty-liver-disease
#16
H Gurel, H Genc, G Celebi, E Sertoglu, A F Cicek, H Kayadibi, C N Ercin, T Dogru
OBJECTIVE: Pentraxin-3 (PTX-3) is an acute-phase protein belonging to the PTX family. It has been reported that PTX-3 is significantly associated with obesity, metabolic syndrome, and cardiovascular diseases (CVD). Non-alcoholic fatty liver disease (NAFLD) is strongly associated with atherosclerosis and CVD. In this study, we aimed to investigate the relationship of PTX-3 with circulating markers of endothelial dysfunction and atherosclerosis in patients with NAFLD. PATIENTS AND METHODS: Seventy patients with biopsy-proven NAFLD and seventy healthy controls were enrolled in the study...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27826342/endocan-and-non-dipping-circadian-pattern-in-newly-diagnosed-essential-hypertension
#17
Tolga Çimen, Murat Bilgin, Ahmet Akyel, Mehmet Ali Felekoğlu, Ali Nallbani, Şeyda Özdemir, Gönül Erden, Alpaslan Öztürk, Mehmet Doğan, Ekrem Yeter
BACKGROUND AND OBJECTIVES: Non-dipper hypertension is frequently accompanied by endothelial dysfunction and activation. Previous studies suggested that endocan may be a novel endothelial dysfunction marker. This study aims to investigate the association between circadian blood pressure (BP) pattern and plasma endocan levels together with high-sensitivity C-reactive protein (hsCRP) in patients with newly diagnosed untreated hypertension. SUBJECTS AND METHODS: Twenty-four hour ambulatory blood pressure monitoring was recorded in 35 dipper, 35 non-dipper hypertensives and 35 healthy controls...
November 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27825611/high-sensitivity-c-reactive-protein-in-stroke-patients-the-importance-in-consideration-of-influence-of-multiple-factors-in-the-predictability-for-disease-severity-and-death
#18
REVIEW
Hong Yu, Yue Huang, XinYu Chen, WenBao Nie, YongJun Wang, Yan Jiao, Guy L Reed, Weikuan Gu, Hong Chen
High sensitivity C-reactive protein (hsCRP) has been evaluated as a biomarker in stroke and relevant pathological diseases. While its predictive values in several pathological phenotypes have been confirmed, controversy exists among different studies. This review summarizes reports of the predictive values of hsCRP for the diagnosis, etiology, prognosis and mortality of stroke diseases. The current literature suggests that CRP expression is influenced by multiple factors, such as polymorphisms, the genomic backgrounds and gender...
November 4, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27816305/the-contributions-of-fasting-and-postprandial-blood-glucose-increments-to-oxidative-stress-and-inflammation-in-dyslipidemic-type-2-diabetic-patients-with-stable-ischemic-heart-disease
#19
Boris Djindjic, Tomislav Kostic, Zoran Radovanovic, Natasa Djindjic, Marko Lazovic, Misko Zivic, Zoran Perisic, Nebojsa Krstic
BACKGROUND/OBJECTIVES: Contributions of fasting and postprandial blood glucose increments on level of inflammation and oxidative stress biomarkers in patients with stable ischemic heart disease (IHD) and diabetes mellitus type 2 (T2DM) was evaluated. METHODOLOGY: Ninety T2DM patients (60 with IHD and 30 without IHD) treated with metformin and/or sulphonylurea were enrolled in cross-sectional nested case-control clinical study. The areas under the six-point daily glucose curve above the fasting glucose concentrations (AUCpp) and over 5...
October 31, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27814269/preprocedural-high-sensitivity-c-reactive-protein-predicts-contrast-induced-nephropathy-and-long-term-outcome-after-coronary-angiography
#20
Xiao-Sheng Guo, Kai-Yang Lin, Hua-Long Li, Ji-Yan Chen, Ying-Ling Zhou, Yong Liu, Ning Tan, Emily R Atkins, Peng Ran, Jun-Qing Yang, Deng-Xuan Wu, Shi-Qun Chen, Chong-Yang Duan, Ping-Yan Chen
We investigated whether high-sensitivity C-reactive protein (hsCRP) levels were associated with contrast-induced nephropathy (CIN) and long-term mortality after coronary angiography (CAG). Patients (N = 2133) undergoing CAG with preprocedural hsCRP were consecutively enrolled. High-sensitivity C-reactive protein was measured before angiography. Median follow-up was 2.3 years. The overall incidence of CIN was 2.77% (59 of 2133). There was a positive trend of hsCRP quartiles (Q) with rates of CIN: 0.9% for Q1 (<1...
October 25, 2016: Angiology
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