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Pleural effusion biochemical markers

Francis J Ha, Hui-Chen Han, Prashanthan Sanders, Andrew W Teh, David O'Donnell, Omar Farouque, Han S Lim
INTRODUCTION: Atrio-esophageal fistula (AEF) is a dire complication of atrial fibrillation ablation. The diagnostic yield of computed tomography (CT) chest, the role and timing of repeat testing, and the value of other investigations in the diagnosis of AEF is uncertain. METHODS: We systematically reviewed published AEF cases to evaluate radiological, bedside and biochemical investigations for AEF (registered on PROSPERO [CRD42017077493]). RESULTS: Eighty-seven articles with 126 patients (median age, 59 years; male, 71%) were included in the analysis...
March 30, 2018: Journal of Cardiovascular Electrophysiology
Chengye Li, Lingxian Hou, Bishundat Yanesh Sharma, Huaizhong Li, ChengShui Chen, Yuping Li, Xuehua Zhao, Hui Huang, Zhennao Cai, Huiling Chen
BACKGROUND AND OBJECTIVE: In countries with high prevalence of tuberculosis (TB), clinicians often diagnose tuberculous pleural effusion (TPE) by using diagnostic tests, which have not only poor sensitivity, but poor availability as well. The aim of our study is to develop a new artificial intelligence based diagnostic model that is accurate, fast, non-invasive and cost effective to diagnose TPE. It is expected that a tool derived based on the model be installed on simple computer devices (such as smart phones and tablets) and be used by clinicians widely...
January 2018: Computer Methods and Programs in Biomedicine
Alexandros Kalkanis, Charalampos Varsamas, Konstantinos Gourgoulianis
BACKGROUND: Quantitative sonographic methods are used to assess pleural fluid's volume but no validated method exists for the measurement of the fluids' density and other qualitative values. We suggest a quantitative method, based on the pixel density of the pleural effusion's image, in order to evaluate the echogenicity of pleural effusion. METHODS: Pleural ultrasound (US) was performed in 62 patients with pleural effusion. Five consequent images of the pleural effusion were retrieved through axial view between the 9(th) and the 10(th) rib and one from the 10(th) rib through coronal view and converted into the high-resolution tagged image file format...
March 2017: Journal of Thoracic Disease
Bastien Mollo, Stéphane Jouveshomme, François Philippart, Benoît Pilmis
Tuberculosis is one of the main etiologies to evoke in the context of lymphocyte pleurisy. However, diagnosis is difficult and is based on mycobacteriology that is not enough sensitive and time-consuming, or on histology that requires invasive biopsy gesture. This literature review, carried out from Medline, summarizes the main meta-analyzes, reviews, and originator publications in English on biomarkers, classic and more innovative, studied for the diagnosis of tuberculous pleurisy. Among the immuno-biochemical markers, interferon-γ (IFN-γ), isoenzyme of adenosine deaminase 2 (ADA2) and total adenosine deaminase (ADA) seem the most relevant with respective sensitivities of 89% (87-91), 97...
February 1, 2017: Annales de Biologie Clinique
Lisete Ribeiro Teixeira, Murilo B Dias, Roberta K B Sales, Leila Antonangelo, Vanessa A Alvarenga, Juliana Puka, Evaldo Marchi, Milena Marques Pagliarelli Acencio
BACKGROUND: Matrix metalloproteinases (MMPs) are responsible for the breakdown of the extracellular matrix and play an important role in the inflammatory processes of pleural exudates. The imbalance between MMPs and their inhibitors (TIMPs) is present in various pathological processes. OBJECTIVE: To evaluate the profile of MMPs and TIMPs in pleural effusions of different etiologies correlated with inflammatory markers. METHODS: The patients with pleural effusion due to tuberculosis (TB), cancer (CA) or transudate were prospectively evaluated...
December 2016: Lung
Alexander Casallas, Camilo Castañeda-Cardona, Diego Rosselli
Urinothorax, the presence of urine in the pleural space, is a rare cause of pleural effusion, usually associated with obstructive uropathy, or urinary trauma. We present the case of a 3 year-old boy and a systematic review of the literature of the 44 cases encountered. After resection of a Wilm's tumour in the right kidney our patient presented acute respiratory distress associated with radiographically confirmed pleural effusion. With the initial diagnosis of pneumonia or malignant pleural effusion, a closed thoracotomy was performed...
January 2016: Urology Annals
Hülya Yilmaz, Gürdal Yilmaz, Uğur Kostakoğlu, Hüseyin Yaman, Asım Örem, İftihar Köksal
Crimean-Congo Hemorrhagic Fever (CCHF) is a disease transmitted by the Crimean-Congo hemorrhagic fever virus (CCHFV), characterized by severe fever and hemorrhage and with a reported fatality level of 3-30%. Cerebral hemorrhage, gastrointestinal hemorrhage, severe anemia, shock, myocardial infarction, pulmonary edema, and pleural effusion may be seen as causes of death. Cardiac troponin T (cTn-T) is a biochemical marker with high sensitivity and specificity in myocardial injury. The purpose of this study was to determine the prognostic significance of serum troponin T levels in CCHF patients...
March 2017: Journal of Medical Virology
Sukru Akyuz, Emre Arugaslan, Ahmet Zengin, Tolga Onuk, Ufuk Sadik Ceylan, Baris Yaylak, Tugba Kemaloglu-Oz, Baris Gungor, Nese Cam
BACKGROUND: The biochemical analysis of pericardial fluid for differentiating transudate from exudate is often ordered and interpreted according to the criteria extrapolated from pleural effusions. However, the validity of this discrimination when applied to pericardial effusion is under question. METHODS: Patients who underwent pericardiocentesis between January 2004 and February 2014 were identified. Among them, 216 had essential medical records available and constituted the study population...
2015: Clinical Laboratory
I Johns, T McParland, T Mair
REASONS FOR PERFORMING STUDY: Pleural effusion (PE) is reported to occur most commonly secondary to bacterial pneumonia or lung abscesses, with neoplastic effusions contributing the minority of cases. The majority of these reports originate from America and Australia, where long distance transport of horses, a recognised risk factor, appears to occur more frequently. Anecdotally, neoplastic PE is more commonly diagnosed in the UK. OBJECTIVES: To describe the causes of PE in horses resident in the UK, and to identify potential markers that can help differentiate between infectious and neoplastic causes of PE...
September 2015: Equine Veterinary Journal
Savas Ozsu, Funda Oztuna, Ahmet Mentese, Yasin Abul, Tevfik Ozlu
INTRODUCTION: Soluble urokinase plasminogen activator receptor (suPAR) is a newly discovered inflammatory biomarker. suPAR has not been previously studied in differentiating noncardiac pleural effusion (PF) from cardiac PF. The aim of our study was to assess the diagnostic value of suPAR in PF. METHODS: The concentration of PF-suPAR was measured by a commercialized enzyme-linked immunosorbent assay in a prospective cohort of 74 patients with PF, 18 patients with PF due to cardiac failure (CF) and 56 patients with noncardiac PF...
January 2016: Clinical Respiratory Journal
Mingying Li, Helin Wang, Xia Wang, Jian Huang, Junxiang Wang, Xiue Xi
BACKGROUND: The current study was performed to investigate the potential biomarkers for the differential diagnosis of tuberculous pleural effusion (TPE) and malignant pleural effusions (MPE). METHODS: Among ninety patients (n = 90) involved in the study, 47 with tuberculous pleural effusion aged from 18 to 70 and 43 with secondary malignant pleural effusion aged from 34 to 78. We tested the pleural levels of TNF-α, IFN-γ and IL-10 as well as the enzyme activity of ADA2, and then we compared the differential diagnostic efficiencies of those biochemical parameters with ADA between the two groups...
2014: Journal of Cardiothoracic Surgery
Silvia Bielsa, Horacio Valencia, Agustín Ruiz-González, Aureli Esquerda, José M Porcel
INTRODUCTION: Distinguishing non-purulent complicated parapneumonic pleural effusions (CPPE) from uncomplicated parapneumonic pleural effusions (UPPE) is challenging. We aimed to determine whether serum C-reactive protein (sCRP), alone or in combination with classical pleural fluid parameters, is useful in making such discrimination. METHODS: The study was composed of a total of 104 consecutive patients, of whom 47 had UPPE and 57 had CPPE. Standard biochemical pleural fluid data along with sCRP were measured...
August 2014: Lung
Lara Milevoj Kopcinovic, Jelena Culej
The pathological accumulation of serous fluids in the pleural, peritoneal and pericardial space occurs in a variety of conditions. Since patient management depends on right and timely diagnosis, biochemical analysis of extravascular body fluids is considered a valuable tool in the patient management process. The biochemical evaluation of serous fluids includes the determination of gross appearance, differentiation of transudative from exudative effusions and additional specific biochemical testing to assess the effusion etiology...
2014: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
Takumi Kishimoto
Asbestosis shows peribronchiolar fibrosis with numerous asbestos bodies. Subpleural dots and curvilinear lines in HRCT are good indicators for the diagnosis of asbestosis. Asbestos-related lung cancer in Japanese Compensation System means lung cancer with asbestosis. Furthermore, pleural plaques and the content of asbestos bodies in the lung tissues with the term of occupational asbestos exposure are good indicators. Mesothelioma induced also by the low dense exposure to asbestos. For the definite diagnosis of mesothelioma, we need histological examination using biopsy and immunochemical staining for positive and negative markers...
February 2014: Nihon Rinsho. Japanese Journal of Clinical Medicine
Keu Sung Lee, Joo Yang Chung, Yun Jung Jung, Wou Young Chung, Joo Hun Park, Seung Soo Sheen, Kyi Beom Lee, Kwang Joo Park
BACKGROUND: Apoptosis plays a role in the development of pleural effusion. Caspase-cleaved cytokeratin 18, a marker for epithelial cell apoptosis, was evaluated in pleural effusion. METHODS: A total of 79 patients with pleural effusion were enrolled. The underlying causes were lung cancer (n=24), parapneumonic effusion (n=15), tuberculous effusion (n=28), and transudates (n=12). The levels of M30, an epitope of caspase-cleaved cytokeratin 18, were measured in blood and pleural fluids using enzyme-linked immunosorbent assay along with routine cellular and biochemical parameters...
January 2014: Tuberculosis and Respiratory Diseases
Nuria Sánchez-Otero, Francisco Javier Rodríguez-Berrocal, María Páez de la Cadena, María Isabel Botana-Rial, Oscar J Cordero
In this study, we measured ADA and DPP-IV enzymatic activity and sCD26 concentration in 150 pleural effusion (PE) samples and tested for correlations between these and other cellular and biochemical measures. We found that DPP-IV in particular might improve the specificity (but not the sensitivity) of the ADA test for diagnosis of pulmonary tuberculosis, since half of the false ADA positive results in non-tuberculous PE were also DPP-IV positive. A percentage of patients with malignant PE were sCD26 or DPP-IV positive; however, some patients with benign PE also tested positive...
2014: Scientific Reports
Yan-Bin Wu, Zhi-Jian Ye, Sou-Ming Qin, Cong Wu, Yi-Qiang Chen, Huan-Zhong Shi
BACKGROUND: Previous studies reported interleukin-27 (IL-27), interferon-γ (IFN-γ), or adenosine deaminase (ADA) alone plays a helpful role in diagnosing tuberculous pleural effusion (TPE). The present study aims at comparing the diagnostic accuracy of pleural IL-27, IFN-γ, and ADA, and investigate the diagnostic accuracy of the combination of IL-27, IFN-γ, or/and ADA for differentiating TPE from pleural effusions with the other etiologies. METHODS: The concentrations of IL-27, IFN-γ and ADA were simultaneously determined in pleural fluids and sera from 40 patients with TPE; 26 with malignant pleural effusion, seven with infectious pleural effusion, and eight with transudative pleural effusion by enzyme linked immunosorbent assay and colorimetric method...
2013: Chinese Medical Journal
Filip Mundt, Gustav Nilsonne, Sertaç Arslan, Karola Csürös, Gunnar Hillerdal, Huseyin Yildirim, Muzaffer Metintas, Katalin Dobra, Anders Hjerpe
PURPOSE: Diagnosis of malignant mesothelioma is challenging. The first available diagnostic material is often an effusion and biochemical analysis of soluble markers may provide additional diagnostic information. This study aimed to establish a predictive model using biomarkers from pleural effusions, to allow early and accurate diagnosis. PATIENTS AND METHODS: Effusions were collected prospectively from 190 consecutive patients at a regional referral centre. Hyaluronan, N-ERC/mesothelin, C-ERC/mesothelin, osteopontin, syndecan-1, syndecan-2, and thioredoxin were measured using ELISA and HPLC...
2013: PloS One
Canan Doğan, Semra Bilaçeroğlu, Ali Kadri Çirak, Ayşe Özsöz, Defne Özbek
INTRODUCTION: To determine the diagnostic value of pleural fluid procalcitonin (PF-PCT) and serum PCT (S-PCT) levels in the diagnosis of parapneumonic pleural effusion (PPPE). MATERIALS AND METHODS: Sixty five inpatients with exudative pleural fluid were consecutively included in this prospective study. Biochemical (total protein, albumin, LDH, glucose, pH, PCT) studies were performed in concurrently obtained pleural fluid and venous blood samples, cytologic and microbiologic (acid-fast bacillus smear/culture, nonspecific bacterial Gram stain/culture, fungal culture) studies were performed in pleural fluid...
2013: Tüberküloz Ve Toraks
Yumin Wang, Zengqiang Chen, Jie Chen, Jingye Pan, Wenhui Zhang, Qinshi Pan, Hongyan Ding, Xiaomei Lin, Xiushu Wen, Yangyang Li, Qing H Meng
BACKGROUND: Apolipoprotein E (apoE) levels have been shown to be elevated in pleural effusion of patients with non-small cell lung cancer (NSCLC). However, the diagnostic value of apoE in pleural effusion in NSCLC has not been well validated and established. METHODS: Samples of malignant pleural effusions (MPE) and benign effusions were collected and analyzed for apoE, tumor markers, and other biochemical changes. RESULTS: ApoE levels were significantly higher in MPE (n=160) than in benign pleural effusions (n=40)...
June 5, 2013: Clinica Chimica Acta; International Journal of Clinical Chemistry
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