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Susan Furth

Meredith A Atkinson, Stephen P Juraschek, Michael S Bertenthal, Barbara Detrick, Susan L Furth, Edgar R Miller
BACKGROUND: Hepcidin is a key mediator of the anemia of chronic kidney disease (CKD). There is emerging evidence that 25-hydroxyvitamin D (25D) regulates hepcidin production. METHODS: A randomized controlled trial of daily vitamin D supplementation for 12 weeks was performed with the aim to test the effects of 4000 versus 400 IU of cholecalciferol on serum hepcidin levels in children with non-dialysis CKD recruited at a tertiary care children's hospital. Hepcidin was quantified using a validated competitive enzyme-linked immunosorbent assay...
December 24, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Csaba P Kovesdy, Susan L Furth, Carmine Zoccali
Obesity is a growing worldwide epidemic. Obesity is one of the strongest risk factors for new-onset chronic kidney disease, and also for nephrolithiasis and for kidney cancer. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle and health policy measures that make preventive behaviors an affordable option.
December 20, 2016: Kidney International
Robert P Woroniecki, Derek K Ng, Sophie Limou, Cheryl A Winkler, Kimberly J Reidy, Mark Mitsnefes, Matthew G Sampson, Craig S Wong, Bradley A Warady, Susan L Furth, Jeffrey B Kopp, Frederick J Kaskel
BACKGROUND AND OBJECTIVES: African-American (AA) children with focal segmental glomerulosclerosis (FSGS) have later onset disease that progresses more rapidly than in non-AA children. It is unclear how APOL1 genotypes contribute to kidney disease risk, progression, and cardiovascular morbidity in children. DESIGN SETTING PARTICIPANTS AND MEASUREMENTS: We examined the prevalence of APOL1 genotypes and associated cardiovascular phenotypes among children with FSGS in the Chronic Kidney Disease in Children (CKiD) study; an ongoing multicenter prospective cohort study of children aged 1-16 years with mild to moderate kidney disease...
2016: Frontiers in Pediatrics
Gregory E Tasian, Michelle E Ross, Lihai Song, Robert W Grundmeier, James Massey, Michelle R Denburg, Lawrence Copelovitch, Steven Warner, Thomas Chi, David W Killilea, Marshall L Stoller, Susan L Furth
PURPOSE: To determine the association between dietary zinc intake and incident calcium kidney stones and examine the relationship between dietary zinc intake and urinary zinc excretion among adolescents. MATERIAL AND METHODS: This study was a nested case-control study conducted within a large pediatric healthcare system. Three 24-hour dietary recalls and spot urine chemistries were obtained for 30 participants aged 12-18 years with a first idiopathic calcium-based kidney stone and 30 healthy controls, matched on age, sex, race, and month of enrollment...
November 23, 2016: Journal of Urology
Tammy M Brady, Kelly Townsend, Michael F Schneider, Christopher Cox, Thomas Kimball, Peace Madueme, Bradley Warady, Susan Furth, Mark Mitsnefes
BACKGROUND: Cardiovascular disease (CVD) is highly prevalent among children with chronic kidney disease (CKD). Cystatin C is an established marker of kidney function and an emerging biomarker for CVD events. We quantified the relationship between cystatin C level and cardiac structure and function over time among children with CKD and assessed whether cystatin C level and diastolic function retained an association after accounting for kidney function. STUDY DESIGN: Prospective cohort study...
November 14, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Alison G Abraham, Aisha Betoko, Jeffrey J Fadrowski, Christopher Pierce, Susan L Furth, Bradley A Warady, Alvaro Muñoz
BACKGROUND: Clinical care decisions to treat chronic kidney disease (CKD) in a growing child must often be made without the benefit of evidence from clinical trials. We used observational data from the Chronic Kidney Disease in Children cohort to estimate the effectiveness of renin-angiotensin II-aldosterone system blockade (RAAS) to delay renal replacement therapy (RRT) in children with CKD. METHODS: A total of 851 participants (median age: 11 years, median glomerular filtration rate [GFR]: 52 ml/min/1...
November 8, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Derek K Ng, Marva Moxey-Mims, Bradley A Warady, Susan L Furth, Alvaro Muñoz
PURPOSE: African American (AA) adults with chronic kidney disease (CKD) have a faster progression to end-stage renal disease and are less likely to receive a kidney transplant. It is unclear whether AA children experience renal replacement therapy (RRT) for end-stage renal disease sooner than non-AA children after accounting for socioeconomic status (SES). METHODS: Among children with nonglomerular CKD in the Chronic Kidney Disease in Children study, we investigated time to RRT (i...
November 2016: Annals of Epidemiology
Wun Fung Hui, Aisha Betoko, Jonathan D Savant, Alison G Abraham, Larry A Greenbaum, Bradley Warady, Marva M Moxey-Mims, Susan L Furth
OBJECTIVE: Our aim was to characterize the nutrient intake of children with chronic kidney disease (CKD) relative to recommended intake levels. METHODS: We conducted a cross-sectional study of dietary intake assessed by Food Frequency Questionnaire (FFQ) in The North American Chronic Kidney Disease in Children (CKiD) prospective cohort study. Nutrient intake was analyzed to estimate the daily consumption levels of various nutrients and compared with national guidelines for intake...
September 29, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Rebecca L Ruebner, Derek Ng, Mark Mitsnefes, Bethany J Foster, Kevin Meyers, Bradley Warady, Susan L Furth
BACKGROUND AND OBJECTIVES: Prior studies suggested that women with CKD have higher risk for cardiovascular disease (CVD) and mortality than men, although putative mechanisms for this higher risk have not been identified. We assessed sex differences in (1) CVD risk factors and left ventricular hypertrophy (LVH), and (2) the relationship of left ventricular mass (LVM) with different measures of body size in children with CKD. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: The study population comprised 681 children with CKD from the Chronic Kidney Disease in Children cohort, contributing 1330 visits...
November 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Thomas Dienemann, Naohiko Fujii, Paula Orlandi, Lisa Nessel, Susan L Furth, Wendy E Hoy, Seiichi Matsuo, Gert Mayer, Shona Methven, Franz Schaefer, Elke S Schaeffner, Laura Solá, Bénédicte Stengel, Christoph Wanner, Luxia Zhang, Adeera Levin, Kai-Uwe Eckardt, Harold I Feldman
BACKGROUND: Chronic kidney disease (CKD) is a global health burden, yet it is still underrepresented within public health agendas in many countries. Studies focusing on the natural history of CKD are challenging to design and conduct, because of the long time-course of disease progression, a wide variation in etiologies, and a large amount of clinical variability among individuals with CKD. With the difference in health-related behaviors, healthcare delivery, genetics, and environmental exposures, this variability is greater across countries than within one locale and may not be captured effectively in a single study...
2016: BMC Nephrology
Anthony A Portale, Myles S Wolf, Shari Messinger, Farzana Perwad, Harald Jüppner, Bradley A Warady, Susan L Furth, Isidro B Salusky
BACKGROUND AND OBJECTIVES: Plasma fibroblast growth factor 23 (FGF23) concentrations increase early in the course of CKD in children. High FGF23 levels associate with progression of CKD in adults. Whether FGF23 predicts CKD progression in children is unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We tested the hypothesis that high plasma FGF23 is an independent risk factor for CKD progression in 419 children, aged 1-16 years, enrolled in the Chronic Kidney Disease in Children (CKiD) cohort study...
November 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Erum A Hartung, Katherine M Dell, Matthew Matheson, Bradley A Warady, Susan L Furth
BACKGROUND: Previous studies have suggested that some children with autosomal recessive polycystic kidney disease (ARPKD) have growth impairment out of proportion to their degree of chronic kidney disease (CKD). The objective of this study was to systematically compare growth parameters in children with ARPKD to those with other congenital causes of CKD in the chronic kidney disease in Children (CKiD) prospective cohort study. METHODS: Height SD scores (z-scores), proportion of children with severe short stature (z-score < -1...
2016: Frontiers in Pediatrics
Gregory E Tasian, Abdo E Kabarriti, Angela Kalmus, Susan L Furth
PURPOSE: Kidney stone disease has become increasingly common during childhood and adolescence. However, the rate of symptomatic kidney stone recurrence for pediatric patients is uncertain. We sought to determine the recurrence rate of symptomatic kidney stones in a cohort of children with incident symptomatic nephrolithiasis. MATERIALS AND METHODS: We performed a retrospective cohort study of patients 3 to 18 years old without anatomical abnormalities or genetic causes of nephrolithiasis who presented with a first symptomatic kidney stone between 2008 and 2014...
January 2017: Journal of Urology
Allison Tong, Susan Samuel, Michael Zappitelli, Allison Dart, Susan Furth, Allison Eddy, Jaap Groothoff, Nicholas J A Webb, Hui-Kim Yap, Detlef Bockenhauer, Aditi Sinha, Stephen I Alexander, Stuart L Goldstein, Debbie S Gipson, Camilla S Hanson, Nicole Evangelidis, Sally Crowe, Tess Harris, Brenda R Hemmelgarn, Braden Manns, John Gill, Peter Tugwell, Wim Van Biesen, David C Wheeler, Wolfgang C Winkelmayer, Jonathan C Craig
BACKGROUND: Children with chronic kidney disease (CKD), requiring dialysis or kidney transplantation, have a mortality rate of up to 30-fold higher than the general aged-matched population, and severely impaired quality of life. Symptoms such as fatigue and pain are prevalent and debilitating. Children with CKD are at risk of cognitive impairment, and poorer educational, vocational, and psychosocial outcomes compared with their well peers, which have consequences through to adulthood...
2016: Trials
Julie C Fitzgerald, Rajit K Basu, Ayse Akcan-Arikan, Ledys M Izquierdo, Byron E Piñeres Olave, Amanda B Hassinger, Maria Szczepanska, Akash Deep, Duane Williams, Anil Sapru, Jason A Roy, Vinay M Nadkarni, Neal J Thomas, Scott L Weiss, Susan Furth
OBJECTIVES: The prevalence of septic acute kidney injury and impact on functional status of PICU survivors are unknown. We used data from an international prospective severe sepsis study to elucidate functional outcomes of children suffering septic acute kidney injury. DESIGN: Secondary analysis of patients in the Sepsis PRevalence, OUtcomes, and Therapies point prevalence study: acute kidney injury was defined on the study day using Kidney Disease Improving Global Outcomes definitions...
December 2016: Critical Care Medicine
Kathryn Malone, Stephanie Clark, Jo Ann Palmer, Sonya Lopez, Madhura Pradhan, Susan Furth, Jason Kim, Brian Fisher, Benjamin Laskin
Pneumococcal vaccination rates among children receiving a kidney transplant remain suboptimal. Current practice guidelines in the United States recommend giving the PPSV23 after priming with the PCV13. We conducted a QI initiative to increase pneumococcal vaccine rates in our kidney transplant recipients by developing an age-based vaccine algorithm, obtaining vaccine records, and generating reminders for patients and clinicians. A monthly report from the EHR tracked outcomes. The process metric was missed vaccine opportunities, and the overall objective was to improve coverage with both the PCV13 and PPSV23...
September 2016: Pediatric Transplantation
Marc B Lande, Susan R Mendley, Matthew B Matheson, Shlomo Shinnar, Arlene C Gerson, Joshua A Samuels, Bradley A Warady, Susan L Furth, Stephen R Hooper
BACKGROUND: Children with chronic kidney disease (CKD) and hypertension have increased blood pressure variability (BPV), which has been associated with lower neurocognitive test scores in adults. Children with CKD are at risk for decreased neurocognitive function. Our objective was to determine whether children with CKD and increased BPV had worse performance on neurocognitive testing compared with children with CKD and lower BPV. METHODS: This was a cross-sectional and longitudinal analysis of the relation between BPV and neurocognitive test performance in children ≥6 years enrolled in the Chronic Kidney Disease in Children (CKiD) study...
November 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Derek K Ng, Catherine C Robertson, Robert P Woroniecki, Sophie Limou, Christopher E Gillies, Kimberly J Reidy, Cheryl A Winkler, Sangeeta Hingorani, Keisha L Gibson, Rebecca Hjorten, Christine B Sethna, Jeffrey B Kopp, Marva Moxey-Mims, Susan L Furth, Bradley A Warady, Matthias Kretzler, John R Sedor, Frederick J Kaskel, Matthew G Sampson
BACKGROUND: Individuals of African ancestry harboring two variant alleles within apolipoprotein L1 (APOL1) are classified with a high-risk (HR) genotype. Adults with an HR genotype have increased risk of focal segmental glomerulosclerosis and chronic kidney disease compared with those with a low-risk (LR) genotype (0 or 1 variants). The role of APOL1 risk genotypes in children with glomerular disease is less well known. METHODS: This study characterized 104 African-American children with a glomerular disease by APOL1 genotype in two cohorts: the Chronic Kidney Disease in Children (CKiD) and Nephrotic Syndrome Study Network (NEPTUNE)...
April 27, 2016: Nephrology, Dialysis, Transplantation
Sheena Sharma, Rebecca L Ruebner, Susan L Furth, Kathryn M Dodds, Jack Rychik, David J Goldberg
OBJECTIVE: The Fontan operation is a palliative procedure for congenital single ventricle heart disease. Long-term kidney function in this cohort is not well-known. Our aim was to evaluate renal function in long-term survivors post-Fontan palliation, and we hypothesize that this cohort will have a higher prevalence of chronic kidney disease (CKD) compared to controls. DESIGN: We performed a retrospective cohort study of 68 subjects evaluated through the Single Ventricle Survivorship Program at the Children's Hospital of Philadelphia between July 2010 and December 2014 compared to 70 healthy children similar in age and sex...
December 2016: Congenital Heart Disease
Katherine Fischer, Chunming Li, Huixuan Wang, Yihua Song, Susan Furth, Gregory E Tasian
PURPOSE: Low renal parenchymal area, which is the gross area of the kidney in maximal longitudinal length minus the area of the collecting system, has been associated with increased risk of end stage renal disease during childhood in boys with posterior urethral valves. To our knowledge normal values do not exist. We aimed to increase the clinical usefulness of this measure by defining normal renal parenchymal area during infancy. MATERIALS AND METHODS: In a cross-sectional study of children with prenatally detected mild unilateral hydronephrosis who were evaluated between 2000 and 2012 we measured the renal parenchymal area of normal kidney(s) opposite the kidney with mild hydronephrosis...
April 2016: Journal of Urology
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