keyword
https://read.qxmd.com/read/38456915/assessment-of-south-asian-pediatric-acute-kidney-injury-epidemiology-and-risk-factors-aspire-a-prospective-study-on-severe-dialysis-dependent-pediatric-aki
#21
JOURNAL ARTICLE
Sidharth Kumar Sethi, Rupesh Raina, Ahmad Sawan, Sadaf Asim, Aye Kyawt Khant, Manoj Matnani, Kalaivani Ganesan, Shraddha Lohia, Rajiv Sinha, Jubaida Rumana, Syed Saimul Haque, Suprita Kalra, Rabia Safdar, Gopal Prasad, Iftikhar Ijaz, Omer S Ashruf, Aishwarya Nair, Savita S, Kritika Soni, Devendra Shrestha, Shankar Yadav, Asiri Abeyagunawardena, Valerie A Luyckx, Khalid A Alhasan, Azmeri Sultana
BACKGROUND: Pediatric acute kidney injury (AKI) is a global health concern with an associated mortality risk disproportionately pronounced in resource-limited settings. There is a pertinent need to understand the epidemiology of pediatric AKI in vulnerable populations. Here, we proposed a prospective study to investigate the epidemiology and associated risk factors of "severe dialysis dependent AKI" in children among South Asian nations which would be the first and largest of its kind...
March 8, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38452996/achieving-consensus-severity-graded-definitions-of-fontan-associated-complications-to-characterize-fontan-circulatory-failure
#22
JOURNAL ARTICLE
Kurt R Schumacher, Ari Cedars, Kiona Allen, David Goldberg, Adrianna Batazzi, Garrett Reichle, Frank DiPaola, David Selewski, Melissa Cousino, David N Rosenthal
BACKGROUND: Fontan physiology leads to chronic changes in other organ systems that may affect long-term survival and the success of heart transplantation. Inadequate assessment and treatment of the extra-cardiac effects of Fontan may contribute to poor outcomes. Severity graded/ordinal consensus definitions of Fontan complications are lacking which limits understanding of how Fontan-specific morbidity affects patient outcomes. METHODS AND RESULTS: A panel of Fontan patient and physiology experts, including pediatric, adult congenital, heart failure, and critical care cardiology, and pediatric nephrology, hepatology and psychology, convened to develop definitions of Fontan complications...
March 5, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38445832/nuclear-medicine-and-pediatric-nephro-urology-a-long-lasting-successful-partnership
#23
JOURNAL ARTICLE
Ana I Santos, Rita T Ferreira
Congenital anomalies of the kidney and urinary tract, as well as urinary infections, are very frequent in children. After the clinical and laboratory evaluation, the first imaging procedure to be done is a renal and bladder ultrasound, but afterwards, a main contribution comes from nuclear medicine. Through minimally invasive and sedation-free procedures, nuclear medicine allows the evaluation of the functional anatomy of the urinary tract, and the quantification of renal function and drainage. If pediatric dosage cards provided by scientific societies are used, radiation exposure can also be low...
March 6, 2024: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38436145/kidney-adolescent-and-young-adult-clinic-a-transition-model-in-africa
#24
REVIEW
Zibya Barday, Bianca Davidson, Paul Harden, Zakira Mukuddem-Sablay, Nicola Wearne, Erika S W Jones, Daley Cross, Mignon McCulloch
Adolescents and Young Adults (AYAs) with chronic kidney disease (CKD) have challenges unique to this developmental period, with increased rates of high-risk behavior and non-adherence to therapy which may impact the progression of kidney disease and their requirement for kidney replacement therapy (KRT). Successful transition of AYA patients are particularly important in low- and middle-income countries (LMICs) where KRT is limited, rationed or not available. Kidney AYA transition clinics have the potential to improve clinical outcomes but there is a paucity of data on the clinical translational impact of these clinics in Africa...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38433569/living-donor-liver-transplantation-for-methylmalonic-acidemia-patient-with-hepatocellular-carcinoma-a-case-report-and-literature-review
#25
REVIEW
Harunori Deguchi, Seisuke Sakamoto, Seiichi Shimizu, Akinari Fukuda, Hajime Uchida, Yusuke Yanagi, Toshimasa Nakao, Tasuku Kodama, Ryuji Komine, Kentaro Nishi, Koichi Kamei, Chizuko Haga, Takako Yoshioka, Kimikazu Matsumoto, Reiko Horikawa, Mureo Kasahara
BACKGROUND: Methylmalonic acidemia (MMA) is an autosomal recessive disorder caused by defects in propionyl-CoA (P-CoA) catabolism; of note, liver neoplasms rarely occur as a long-term complication of the disorder. Herein, we report the case of a patient with MMA and hepatocellular carcinoma (HCC) who was successfully treated with a living-donor liver transplant (LDLT) following prior kidney transplantation. CASE REPORT: A 25-year-old male patient with MMA underwent LDLT with a left lobe graft because of metabolic instability and liver neoplasms...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38430280/galectin-3-levels-in-children-with-cystic-fibrosis
#26
JOURNAL ARTICLE
Dilber Ademhan Tural, Nagehan Emiralioglu, Senay Akin, Didem Alboga, Beste Ozsezen, Halime Nayir Buyuksahin, Ismail Guzelkas, Merve Kasikci, Birce Sunman, Irem Gungor, Ebru Yalcin, Deniz Dogru, Nural Kiper, Ali Haydar Demirel, Ugur Ozcelik
Cystic fibrosis (CF) is a multisystemic disease in which airway obstruction, infection, and inflammation play a critical role in the pathogenesis and progression of CF lung disease. The carbohydrate-binding protein Galectin-3 is increased in several inflammatory and fibrotic diseases and has recently been forwarded as a biomarker in these diseases. We aimed to define the role of serum Galectin-3 in children with CF by comparison with healthy subjects. This is a cross-sectional, case-control study. 143 CF and 30 healthy subjects were enrolled in the study...
March 2, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38427073/comparison-of-estimated-gfr-using-cystatin-c-versus-creatinine-in-pediatric-kidney-transplant-recipients
#27
JOURNAL ARTICLE
Helen Pizzo, John Nguyen, George J Schwartz, Katherine Wesseling-Perry, Robert Ettenger, Eileen Tsai Chambers, Patricia Weng
BACKGROUND: An accurate, rapid estimate of glomerular filtration rate (GFR) in kidney transplant patients affords early detection of transplant deterioration and timely intervention. This study compared the performance of serum creatinine (Cr) and cystatin C (CysC)-based GFR equations to measured GFR (mGFR) using iohexol among pediatric kidney transplant recipients. METHODS: CysC, Cr, and mGFR were obtained from 45 kidney transplant patients, 1-18 years old...
March 1, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38425668/management-of-pediatric-obesity-as-a-pathway-towards-kidney-transplantation
#28
REVIEW
K E Altemose, C Nailescu
Obesity is an increasing problem in pediatrics, leading to cardiovascular, metabolic and psychosocial complications. Additionally, for patients with chronic kidney disease (CKD), obesity can lead to CKD progression towards end-stage renal disease (ESRD) needing renal-replacement therapy (RRT). It is well-established that the optimal type of RRT for children with ESRD is kidney transplantation, as it provides significantly better life expectancy and quality of life. Unfortunately, pediatric patients with CKD/ESRD and obesity face barriers getting to kidney transplantation and often remain on dialysis for a long time, which negatively impacts their life expectancy and quality of life...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38403392/building-partnerships-to-improve-health-outcomes-pediatric-patient-and-family-engagement-in-nephrology-practice
#29
REVIEW
Taylor R House, Kelly Helm, Aaron Wightman
As health care practices have evolved from a disease-oriented to patient-focused paradigm, patient and family engagement (PFE) has been recognized as an important aspect of health care delivery and outcomes. While pediatricians have long approached care delivery with a family-centered lens, PFE may be a less familiar concept to situate among related concepts such as shared decision-making, self-efficacy, patient activation, and family-centered care. Children with CKD and their families indicate a need and desire for enhanced PFE efforts in pediatric nephrology...
January 2024: Adv Kidney Dis Health
https://read.qxmd.com/read/38398863/not-only-metabolic-complications-of-childhood-obesity
#30
REVIEW
Sebastian Ciężki, Emilia Odyjewska, Artur Bossowski, Barbara Głowińska-Olszewska
The increasing incidence of obesity in the pediatric population requires attention to its serious complications. It turns out that in addition to typical, well-known metabolic complications, obesity as a systemic disease carries the risk of equally serious, although less obvious, non-metabolic complications, such as cardiovascular diseases, polycystic ovary syndrome, chronic kidney disease, asthma, thyroid dysfunction, immunologic and dermatologic conditions, and mental health problems. They can affect almost all systems of the young body and also leave their mark in adulthood...
February 15, 2024: Nutrients
https://read.qxmd.com/read/38396091/assessing-bias-in-gfr-estimating-equations-improper-gfr-stratification-can-yield-misleading-results
#31
JOURNAL ARTICLE
Derek K Ng, Alvaro Muñoz
BACKGROUND: Assessing bias (estimated - measured) is key to evaluating glomerular filtration rate (GFR). Stratification by subgroups can indicate where equations perform differently. However, there is a fallacy in the assessment of two instruments (e.g., eGFR and mGFR) when stratifying on the level of only one of those instruments. Here, we present statistical aspects of the problem and a solution for GFR stratification along with an empirical investigation using data from the CKiD study...
February 24, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38389150/longitudinal-progression-trajectory-of-estimated-glomerular-filtration-rate-in-children-with-chronic-kidney-disease-results-from-the-know-ped-ckd-korean-cohort-study-for-outcomes-in-patients-with-pediatric-chronic-kidney-disease
#32
JOURNAL ARTICLE
Eun Mi Yang, Jayoun Kim, Eujin Park, Kyoung Hee Han, Seong Heon Kim, Heeyeon Cho, Jae Il Shin, Min Hyun Cho, Joo Hoon Lee, Ji Hyun Kim, Hee Gyung Kang, Il-Soo Ha, Yo Han Ahn
BACKGROUND: The natural course of chronic kidney disease (CKD) progression in children varies according to their underlying conditions. This study aims to identify different patterns of subsequent decline in kidney function and investigate factors associated with different patterns of estimated glomerular filtration rate (eGFR) trajectories. METHODS: We analyzed data from the KNOW-Ped CKD (KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease), which is a longitudinal, prospective cohort study...
February 23, 2024: Kidney Research and Clinical Practice
https://read.qxmd.com/read/38385412/immunity-rates-of-live-viral-vaccines-in-pediatric-renal-transplant-candidates-a-single-center-experience
#33
REVIEW
Betul Orhan Kilic, Esra Baskin, Kaan Gulleroglu, Serhat Kilic, Beril Aydin, Ozlem Akbulut, Mehmet Haberal
OBJECTIVES: Solid-organ transplant recipients are at an increased risk of severe infections due to their immunosuppressed state. Despite the recommendation of routine screening and vaccination before transplant to mitigate this danger, vaccination rates in these patients are still below desirable levels. We aimed to investigate the prevalence of positive antibody rates for measles, mumps, rubella, and varicella among children who are candidates for renal transplant. MATERIALS AND METHODS: This retrospective study was conducted at a single center and included 144 pediatric kidney transplant patients for the past 7 years...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38374662/hepatic-artery-vasospasm-masquerading-as-early-hepatic-artery-thrombosis-in-progressive-familial-intrahepatic-cholestasis-3-a-case-report
#34
Divij Jayant, Swapnesh Sahu, Basil Babu, Cherring Tandup, Arunanshu Behera
Post-liver transplant (LT) hepatic artery vasospasm is a vascular complication that is not well recognized and its incidence is not known. As a possible sequela to vasospasm, hepatic artery thrombosis is the second major cause of allograft failure after primary nonfunction and its reported incidence is 2.9% in adults and 8.3% in pediatric LT. Lacuna in knowledge regarding early hepatic artery vasospasm post-LT makes it a difficult condition to diagnose and treat, as the initial ischemic insult on graft can have devastating consequences...
February 20, 2024: Korean journal of transplantation
https://read.qxmd.com/read/38374220/early-postnatal-nutrition-and-renal-consequences-in-preterm-infants
#35
REVIEW
Silvia Iacobelli, Alexandre Lapillonne, Farid Boubred
Perinatal nutritional factors may lead to decreased nephron endowment, decreased kidney function, and long-term development of chronic kidney disease and non-communicable diseases. At the same time, optimal postnatal nutrition and catch-up growth are associated with better neurodevelopmental outcomes in preterm infants. Therefore, nutritional management of preterm infants is a major challenge for neonatologists. In this context, the Section of Nutrition, Gastroenterology and Metabolism reviewed the current knowledge on nutritional issues related to kidney function...
February 19, 2024: Pediatric Research
https://read.qxmd.com/read/38370350/case-report-a-novel-compound-heterozygous-variant-in-the-tnxb-gene-causes-single-kidney-agenesis-and-vesicoureteral-reflux
#36
Lei Liang, Haotian Wu, Haixia Meng, Lin Fu, Jianrong Zhao
Primary vesicoureteral reflux (VUR) is the prevailing congenital anomaly of the kidneys and urinary tract, posing a significant risk for pyelonephritis scarring and chronic renal insufficiency in pediatric patients. Nevertheless, the precise genetic etiology of VUR remains enigmatic. In this current investigation, we conducted whole-exome sequencing on a child exhibiting single kidney, devoid of any familial VUR background, along with both biological parents. Two missense variants (NM_019105.8: exon11: c.4111G>A and NM_019105...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38369813/a-quantitative-assessment-of-renal-function-utilizing-albuminuria-in-pediatric-heart-transplant-recipients
#37
JOURNAL ARTICLE
Erik L Frandsen, Richard A Kronmal, Erin A Albers, Joshua M Friedland-Little, Borah J Hong, Katherine L Spencer, Sangeeta R Hingorani, Yuk M Law
INTRODUCTION: Kidney disease is common after pediatric heart transplantation. Serum creatinine-based glomerular filtration rate is the most frequently reported measure of kidney function. Albuminuria is an additional marker of kidney dysfunction and is not well described in this population. In this study, we evaluate the prevalence and degree of albuminuria and describe clinical factors associated with albuminuria in a cohort of pediatric heart transplant recipients. METHODS: This was a cross-sectional study of pediatric heart transplant recipients...
February 2024: Clinical Transplantation
https://read.qxmd.com/read/38366741/temporal-changes-in-pre-existing-health-conditions-five-years-prior-to-pregnancy-in-british-columbia-canada-2000-2019
#38
JOURNAL ARTICLE
Louise Lundborg, K S Joseph, Sarka Lisonkova, Wee-Shian Chan, Qi Wen, Cande V Ananth, Neda Razaz
BACKGROUND: Pre-existing health conditions increase the risk of obstetric complications during pregnancy and birth. However, the prevalence and recent changes in the frequency of pre-existing health conditions in the childbearing population remain unknown. OBJECTIVES: To estimate the temporal changes in the prevalence of pre-existing health conditions among pregnant women in British Columbia, Canada. METHODS: We carried out a population-based cross-sectional study of 825,203 deliveries in BC between 2000 and 2019 and examined 17 categories of physical and psychiatric health conditions recorded within 5 years before childbirth...
February 17, 2024: Paediatric and Perinatal Epidemiology
https://read.qxmd.com/read/38347283/hemodiafiltration-for-children-with-stage-5-chronic-kidney-disease-technical-aspects-and-outcomes
#39
JOURNAL ARTICLE
Charlotte Ahlmann, Lynsey Stronach, Kathryn Waters, Kate Walker, Jun Oh, Claus Peter Schmitt, Bruno Ranchin, Rukshana Shroff
Despite significant medical and technical improvements in the field of dialysis, the morbidity and mortality among patients with chronic kidney disease (CKD) stage 5 on dialysis remains extremely high. Hemodiafiltration (HDF), a dialysis method that combines the two main principles of hemodialysis (HD) and hemofiltration-diffusion and convection-has had a positive impact on survival when delivered with a high convective dose. Improved outcomes with HDF have been attributed to the following factors: HDF removes middle molecular weight uremic toxins including inflammatory cytokines, increases hemodynamic stability, and reduces inflammation and oxidative stress compared to conventional HD...
February 13, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38347282/the-effect-of-gastrostomy-tube-feeding-on-growth-in-children-with-chronic-kidney-disease-and-on-dialysis
#40
JOURNAL ARTICLE
Abdulelah Alshaiban, Adebola Osuntoki, Shelley Cleghorn, Antonia Loizou, Rukshana Shroff
BACKGROUND: Gastrostomy tube (GT) feeding is used to promote nutrition and growth in children with chronic kidney disease (CKD). We explored the relationship between gastrostomy feeding and growth parameters in children with CKD, looking specifically at the nutritional composition of feeds. METHODS: Children with CKD stages 3-5 or on dialysis in a tertiary children's kidney unit were studied. Data on anthropometry, biochemistry, and nutritional composition of feeds were collected from the time of GT insertion for 3 years or until transplantation...
February 13, 2024: Pediatric Nephrology
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