Gloria Biechele, Tanja Blume, Maximilian Deussing, Benedikt Zott, Yuan Shi, Xianyuan Xiang, Nicolai Franzmeier, Gernot Kleinberger, Finn Peters, Katharina Ochs, Carola Focke, Christian Sacher, Karin Wind, Claudio Schmidt, Simon Lindner, Franz-Josef Gildehaus, Florian Eckenweber, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Karlheinz Baumann, Mario M Dorostkar, Axel Rominger, Paul Cumming, Michael Willem, Helmuth Adelsberger, Jochen Herms, Matthias Brendel
Modulation of the innate immune system is emerging as a promising therapeutic strategy against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect are ill-understood. Thus, we investigated the potential of 18 kDa translocator protein positron-emission-tomography (TSPO-PET) for assessment of microglial activation in mouse brain before and during chronic immunomodulation. Methods: Serial TSPO-PET was performed during five months of chronic microglia modulation by stimulation of the peroxisome proliferator-activated receptor (PPAR)-γ with pioglitazone in two different mouse models of AD (PS2APP, AppNL-G-F )...
2021: Theranostics