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https://www.readbyqxmd.com/read/27920591/left-atrial-myxomectomy-with-intraoperative-severe-mitral-regurgitation-and-complicated-postoperative-course-case-report
#1
Nareg Minaskeian, Patrick P Hu
Primary cardiac tumors are a rare occurrence with myxomas accounting for about half of the benign tumors. Once diagnosed, surgical resection is the standard of care. Our case describes a female in her 50s who underwent a myxoma resection under cardiopulmonary bypass via biatrial approach. Intraoperatively, the thin septal crux between the wall of the aorta and mitral valve was damaged during resection, requiring stem cell tissue matrix for repair. The patient also developed severe mitral regurgitation suggesting infarct to the left coronary system during resection, subsequently receiving a mechanical mitral valve and a saphenous vein bypass graft...
2016: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/27873022/current-rare-indications-and-future-directions-for-implantable-loop-recorders
#2
Simon Wechselberger, Christopher Piorkowski, Matthias Pohl
The scope of application for implantable loop recorders has shifted away from the evaluation of unclear palpitations and syncope episodes to more complex conditions. This article focuses on rare indications of growing importance such as rhythm monitoring after ablation of atrial fibrillation or after cryptogenic stroke. Furthermore, forthcoming applications in various clinical settings are described, e. g., arrhythmia detection after myocardial infarction, after catheter-based valve interventions, in heart failure, and in cardiomyopathies...
December 2016: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/27864249/positive-predictive-value-of-cardiovascular-diagnoses-in-the-danish-national-patient-registry-a-validation-study
#3
Jens Sundbøll, Kasper Adelborg, Troels Munch, Trine Frøslev, Henrik Toft Sørensen, Hans Erik Bøtker, Morten Schmidt
OBJECTIVE: The majority of cardiovascular diagnoses in the Danish National Patient Registry (DNPR) remain to be validated despite extensive use in epidemiological research. We therefore examined the positive predictive value (PPV) of cardiovascular diagnoses in the DNPR. DESIGN: Population-based validation study. SETTING: 1 university hospital and 2 regional hospitals in the Central Denmark Region, 2010-2012. PARTICIPANTS: For each cardiovascular diagnosis, up to 100 patients from participating hospitals were randomly sampled during the study period using the DNPR...
November 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27861432/the-association-between-preoperative-hemoglobin-a1c-and-postoperative-glycemic-variability-on-30-day-major-adverse-outcomes-following-isolated-cardiac-valvular-surgery
#4
Amit Bardia, Kamal Khabbaz, Ariel Mueller, Priyam Mathur, Victor Novack, Daniel Talmor, Balachundhar Subramaniam
BACKGROUND: Preoperative hemoglobin A1c (HbA1c) and postoperative glycemic variability predict major adverse events (MAEs) after coronary artery bypass grafting in a protocolized glycemic control setting. However, the influence of preoperative HbA1c and postoperative glycemic variability in isolated cardiac valvular surgery is unknown. In this study, we sought to establish (a) whether preoperative HbA1c could identify patients at increased risk of MAEs and (b) whether postoperative glycemic variability was associated with MAEs after isolated cardiac valvular surgery...
November 17, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27834123/translational-applications-of-tissue-engineering-in-cardiovascular-medicine
#5
Y Murat Elçin, Arin Dogan, Eser Elçin
Cardiovascular diseases are the leading cause of worldwide deaths. Current paradigm in medicine seeks novel approaches for the treatment of progressive or end-stage diseases. The organ transplantation option is limited in availability and unfortunately, a great number of patients are lost while waiting for donor organs. Animal studies have shown that upon myocardial infarction, it may be possible to stop adverse remodeling in its tracks and reverse with tissue engineering methods. Regaining the myocardium function and avoiding further deterioration towards heart failure can benefit millions of people with a significantly lesser burden on healthcare systems worldwide...
November 11, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27755256/cardiac-rehabilitation-after-heart-valve-surgery-improvement-in-exercise-capacity-and-morbidity
#6
Agathe Gerwina Elena Pollmann, Marianne Frederiksen, Eva Prescott
PURPOSE: Evidence of the effect of cardiac rehabilitation (CR) after heart valve surgery is scarce, but nevertheless CR is recommended for this group of patients. Therefore, this study assessed the effect of CR on exercise capacity, cardiovascular risk factors, and long-term mortality and morbidity, as well as predictors for enrolment in or failing to complete CR. METHODS: A review of medical records identified 250 patients who underwent heart valve surgery between January 2009 and August 2013...
October 14, 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/27716706/double-valve-replacement-in-a-patient-with-implantable-cardioverter-defibrillator-with-severe-left-ventricular-dysfunction
#7
Girish Manjunath, Prakash Rao, Nagendra Prakash, B K Shivaram
Recent data from landmark trials suggest that the indications for cardiac pacing and implantable cardioverter defibrillators (ICDs) are set to expand to include heart failure, sleep-disordered breathing, and possibly routine implantation in patients with myocardial infarction and poor ventricular function.[1] This will inevitably result in more patients with cardiac devices undergoing surgeries. Perioperative electromagnetic interference and their potential effects on ICDs pose considerable challenges to the anesthesiologists...
October 2016: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/27538860/swine-sus-scrofa-as-a-model-of-postinfarction-mitral-regurgitation-and-techniques-to-accommodate-its-effects-during-surgical-repair
#8
Eric L Sarin, Weiwei Shi, Rajnish Duara, Todd A Melone, Kanika Kalra, Ashley Strong, Apoorva Girish, Bryant V McIver, Vinod H Thourani, Robert A Guyton, Muralidhar Padala
Mitral regurgitation (MR) is a common heart-valve lesion after myocardial infarction in humans. Because it is considered a risk factor for accelerated heart failure and death, various surgical approaches and catheter-based devices to correct it are in development. Lack of a reproducible animal model of MR after myocardial infarction and reliable techniques to perform open-heart surgery in these diseased models led to the use of healthy animals to test new devices. Thus, most devices that are deemed safe in healthy animals have shown poor results in human efficacy studies, hampering progress in this area of research...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27486164/assessing-optimal-blood-pressure-in-patients-with-asymptomatic-aortic-valve-stenosis-the-simvastatin-ezetimibe-in-aortic-stenosis-study-seas
#9
Olav W Nielsen, Ahmad Sajadieh, Muhammad Sabbah, Anders M Greve, Michael H Olsen, Kurt Boman, Christoph A Nienaber, Y Antero Kesäniemi, Terje R Pedersen, Ronnie Willenheimer, Kristian Wachtell
BACKGROUND: Evidence for treating hypertension in patients with asymptomatic aortic valve stenosis is scarce. We used data from the SEAS trial (Simvastatin Ezetimibe in Aortic Stenosis) to assess what blood pressure (BP) would be optimal. METHODS: A total of 1767 patients with asymptomatic aortic stenosis and no manifest atherosclerotic disease were analyzed. Outcomes were all-cause mortality, cardiovascular death, heart failure, stroke, myocardial infarction, and aortic valve replacement...
August 9, 2016: Circulation
https://www.readbyqxmd.com/read/27440307/association-of-thoracic-aorta-calcium-score-with-left-ventricular-hypertrophy-and-clinical-outcomes-in-patients-with-severe-aortic-stenosis-after-aortic-valve-replacement
#10
In-Jeong Cho, Hyuk-Jae Chang, Ran Heo, In-Cheol Kim, Ji Min Sung, Byung-Chul Chang, Chi Young Shim, Geu-Ru Hong, Namsik Chung
BACKGROUND: Substantial aortic calcification is known to be associated with aortic stiffening and subsequent left ventricular (LV) hypertrophy. This study examined whether the thoracic aorta calcium score (TACS) is related to LV hypertrophy and whether it leads to an adverse prognosis in patients with severe aortic stenosis (AS) after aortic valve replacement (AVR). METHODS: We retrospectively reviewed 47 patients (mean age, 64 ± 11 years) with isolated severe AS who underwent noncontrast computed tomography of the entire thoracic aorta and who received AVR...
July 17, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27435836/the-effect-of-dexmedetomidine-on-outcomes-of-cardiac-surgery-in-elderly-patients
#11
Hao Cheng, Zhongmin Li, Nilas Young, Douglas Boyd, Zane Atkins, Fuhai Ji, Hong Liu
OBJECTIVE: The goal of this retrospective study was to investigate the effects of perioperative use of dexmedetomidine (Dex) on outcomes for older patients undergoing cardiac surgery. DESIGN: Retrospective investigation. SETTING: Patients from a single tertiary medical center. PARTICIPANTS: A total of 505 patients (≥65 years old) who underwent coronary artery bypass graft (CABG) or valve surgery. CABG and/or valve surgery plus other procedures were divided into 2 groups: 283 received intravenous Dex infusion (Dex group) and 222 did not (Non-Dex group)...
December 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27420053/micrornas-in-valvular-heart-diseases-potential-role-as-markers-and-actors-of-valvular-and-cardiac-remodeling
#12
REVIEW
Cécile Oury, Laurence Servais, Nassim Bouznad, Alexandre Hego, Alain Nchimi, Patrizio Lancellotti
miRNAs are a class of over 5000 noncoding RNAs that regulate more than half of the protein-encoding genes by provoking their degradation or preventing their translation. miRNAs are key regulators of complex biological processes underlying several cardiovascular disorders, including left ventricular hypertrophy, ischemic heart disease, heart failure, hypertension and arrhythmias. Moreover, circulating miRNAs herald promise as biomarkers in acute myocardial infarction and heart failure. In this context, this review gives an overview of studies that suggest that miRNAs could also play a role in valvular heart diseases...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27339489/treatment-of-chronic-functional-mitral%C3%A2-valve-regurgitation-with-a-percutaneous-annuloplasty-system
#13
Georg Nickenig, Robert Schueler, Antonio Dager, Pedro Martinez Clark, Alexandre Abizaid, Tomasz Siminiak, Pawel Buszman, Marcin Demkow, Adrian Ebner, Federico M Asch, Christoph Hammerstingl
BACKGROUND: Current surgical and medical treatment options for functional mitral regurgitation (FMR) are limited and additional interventional approaches are required. OBJECTIVES: This study sought to report the safety and performance data from the feasibility study with a novel direct annuloplasty system. METHODS: Seventy-one patients with moderate to severe FMR (mean 67.7 ± 11.3 years of age, left ventricular [LV] ejection fraction 34.0 ± 8...
June 28, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27243581/posttranscatheter-aortic-valve-replacement-ventricular-septal-defect-during-transfemoral-edwards-sapien-valve-implantation
#14
Aaron Dahl, Carli Hoaglan, James Helman
Transcatheter aortic valve replacement (TAVR) is gaining favor as a treatment for aortic stenosis in patients at high risk for the open surgical approach. The following is a report of a 95-year-old woman with severe aortic stenosis who presented for TAVR with an Edwards SAPIEN valve. Her medical history included pacemaker-dependent complete heart block and a recent episode of congestive heart failure secondary to a non-ST segment elevation myocardial infarction. The TAVR was performed successfully through an open left femoral artery approach, and the patient was found to have a new perimembranous ventricular septal defect identified postoperatively...
June 1, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27219528/withdrawn-preoperative-statin-therapy-for-patients-undergoing-cardiac-surgery
#15
REVIEW
Elmar W Kuhn, Ingo Slottosch, Thorsten Wahlers, Oliver J Liakopoulos
No abstract text is available yet for this article.
May 24, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27164905/9th-hatter-biannual-meeting-position-document-on-ischaemia-reperfusion-injury-conditioning-and-the-ten-commandments-of-cardioprotection
#16
REVIEW
R M Bell, H E Bøtker, R D Carr, S M Davidson, J M Downey, D P Dutka, G Heusch, B Ibanez, R Macallister, C Stoppe, M Ovize, A Redington, J M Walker, D M Yellon
In the 30 years since the original description of ischaemic preconditioning, understanding of the pathophysiology of ischaemia/reperfusion injury and concepts of cardioprotection have been revolutionised. In the same period of time, management of patients with coronary artery disease has also been transformed: coronary artery and valve surgery are now deemed routine with generally excellent outcomes, and the management of acute coronary syndromes has seen decade on decade reductions in cardiovascular mortality...
July 2016: Basic Research in Cardiology
https://www.readbyqxmd.com/read/27120943/-clinical-characteristic-of-patients-with-acute-kidney-injury-complicated-severe-cardio-vascular-diseases
#17
Paweł Wróbel, Grażyna Wyrwicz-Zielińska, Izabela Krzysztonek-Weber, Władysław Sułowicz
INTRODUCTION: Patients with cardiovascular diseases are a group of increased risk of acute kidney injury (AKI). Mortality in this group of patients with AKI, especially treated in intensive care units, is very high. The aim of this study was to evaluate the clinical characteristic of patients with AKI complicated severe cardiovascular diseases. MATERIAL AND METHODS: Retrospective evaluation of 246 questionnaire of patients with AKI in the course of severe cardiovascular diseases treated in the wards of nephrological profile from the malopolska and podkarpackie voivodships in the years 2000-2011 was performed...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27079193/metabolically-inactive-glucagon-like-peptide-1-9-36-amide-confers-selective-protective-actions-against-post-myocardial-infarction-remodelling
#18
Emma Robinson, Mitchel Tate, Samuel Lockhart, Claire McPeake, Karla M O'Neill, Kevin S Edgar, Danielle Calderwood, Brian D Green, Barbara J McDermott, David J Grieve
BACKGROUND: Glucagon-like peptide-1 (GLP-1) therapies are routinely used for glycaemic control in diabetes and their emerging cardiovascular actions have been a major recent research focus. In addition to GLP-1 receptor activation, the metabolically-inactive breakdown product, GLP-1(9-36)amide, also appears to exert notable cardiovascular effects, including protection against acute cardiac ischaemia. Here, we specifically studied the influence of GLP-1(9-36)amide on chronic post-myocardial infarction (MI) remodelling, which is a major driver of heart failure progression...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27004709/mrna-pgc-1%C3%AE-levels-in-blood-samples-reliably-correlates-with-its-myocardial-expression-study-in-patients-undergoing-cardiac-surgery
#19
Oscar Fabregat-Andres, Federico Paredes, María Monsalve, Javier Milara, Francisco Ridocci-Soriano, Sonia Gonzalez-Hervas, Armando Mena, Lorenzo Facila, Fernando Hornero, Salvador Morell, Juan Martinez-Leon, Julio Cortijo
OBJECTIVE: Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that has been proposed to play a protective role in mouse models of cardiac ischemia and heart failure, suggesting that PGC-1α could be relevant as a prognostic marker. Our previous studies showed that the estimation of peripheral mRNA PGC-1α expression was feasible and that its induction correlated with the extent of myocardial necrosis and left ventricular remodeling in patients with myocardial infarction...
November 26, 2015: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/26966020/late-survival-and-heart-failure-after-transcatheter-aortic-valve-implantation
#20
Malin Johansson, Shahab Nozohoor, Henrik Bjursten, Sigurdur Ragnarsson, Matthias Götberg, Per Ola Kimblad, Igor Zindovic, Johan Sjögren
BACKGROUND: Short-term survival in patients undergoing transcatheter aortic valve implantation is favorable. Our aim was to evaluate late survival and composite clinical endpoints specified by the Valve Academic Research Consortium-2, including rehospitalization for congestive heart failure. METHODS: Between January 2008 and April 2014, 166 consecutive patients with severe symptomatic aortic stenosis underwent 168 transcatheter aortic valve implantation procedures at our facility...
May 2016: Asian Cardiovascular & Thoracic Annals
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