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Fresh embryo transfer

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https://www.readbyqxmd.com/read/28544972/the-effect-of-elevated-progesterone-levels-before-oocyte-retrieval-in-women-undergoing-ovarian-stimulation-for-ivf-treatment-on-the-genomic-profile-of-peri-implantation-endometrium
#1
Liu Liu, Jin Huang, Tin Chiu Li, Xu Tao Hong, Susan Laird, Yong Dong Dai, Xiao Mei Tong, Hai Yan Zhu, Songying Zhang
To evaluate the effects of high progesterone prior to oocyte retrieval on the genomic profile of peri-implantation endometrium, we conducted this single-center, prospective cohort study. Depending on whether or not the progesterone level on the day of hCG administration and the day after hCG administration were elevated, a total of 20 women undergoing IVF treatment who did not have fresh embryo transfer were included: Group 1 refers to subjects with normal progesterone level on both days; Group 2 refers to subjects with normal progesterone level on the day of hCG administration and high progesterone level on the day after hCG administration; Group 3 refers to subjects with high progesterone level on the day of hCG administration and normal progesterone level on the day after hCG administration; Group 4 refers to subjects with high progesterone level on both days...
May 17, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28540311/impacts-of-anti-dsdna-antibody-on-in-vitro-fertilization-embryo-transfer-and-frozen-thawed-embryo-transfer
#2
Jiao Fan, Yiping Zhong, Cuina Chen
Our purpose is to explore whether anti-dsDNA antibody, which was demonstrated to enter living cells and induced apoptosis, could adversely affect reproductive outcomes. A total of 259 women receiving the in vitro fertilization-embryo transfer (IVF) cycle were enrolled in this study, including 52 women with positive ANA and anti-dsDNA (ANA+/anti-dsDNA+ group), 86 women with positive ANA and negative anti-dsDNA (ANA+/anti-dsDNA- group), and 121 women with negative ANA and anti-dsDNA (ANA-/anti-dsDNA- group). 136 nonpregnant women among 259 patients in the IVF-ET cycle were enrolled in the hormone replacement therapy frozen-thawed embryo transfer (HRT-TET) cycle...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28511712/what-we-learned-from-extended-culture-of-rejected-day-3-cleavage-stage-embryos-a-prospective-cohort-study
#3
Anat Hershko Klement, Michal Ovadia, Amir Wiser, Arie Berkovitz, Tal Shavit, Luba Nemerovsky, Yehudith Ghetler, Ilan Cohen, Adrian Shulman
BACKGROUND: To test whether poor quality day-3 embryos can undergo successful blastulation and implantation. METHODS: A prospective cohort study was conducted. Whether or not a good quality embryo was transferred on day-3, poor quality (rejected) embryos were further cultured and followed. The clinical outcome of each embryo was assessed. RESULTS: A total of 694 rejected embryos (from 205 patients) were included, with a blastulation rate of 21...
May 16, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28506949/frozen-embryo-transfer-prevents-the-detrimental-effect-of-high-estrogen-on-endometrium-receptivity
#4
Aynur Adeviye Erşahin, Mustafa Acet, Suat Süphan Erşahin, Nur Dokuzeylül Güngör
OBJECTIVE: To investigate whether serum levels of estradiol affect reproductive outcomes of normoresponder women undergoing fresh embryo transfer (ET) versus frozen-thawed ET (FET). MATERIAL AND METHODS: Two hundred fifty-five normoresponder women underwent fresh ET in their first or second in vitro fertilization cycle. Ninety-two women with negative pregnacy test results underwent FET. Clinical and ongoing pregnancy rates, implantation, and live birth rates of women undergoing fresh ET versus FET were compared...
March 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28505290/supraphysiologic-estradiol-is-an-independent-predictor-of-low-birth-weight-in-full-term-singletons-born-after-fresh-embryo-transfer
#5
N Pereira, R T Elias, P J Christos, A C Petrini, K Hancock, J P Lekovich, Z Rosenwaks
STUDY QUESTION: Is supraphysiologic estradiol (E2) an independent predictor of low birth weight (LBW) in singletons born after fresh IVF-embryo transfer (ET) cycles? SUMMARY ANSWER: Our results suggest that E2 > 2500 pg/ml is an independent predictor for LBW in full-term singletons born to normal responder patients undergoing fresh IVF-ET cycles. WHAT IS KNOWN ALREADY: The pathogenesis of LBW in IVF singletons remains unknown. However, recent studies have suggested that the hyperestrogenic milieu generated during ovarian stimulation may create a sub-optimal peri-implantation environment, leading to placental dysfunction, and therefore, LBW...
May 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28501865/fresh-and-frozen-thawed-embryo-transfer-compared-to-natural-conception-differences-in-perinatal-outcome
#6
Suzanne Spijkers, Jan Willem Lens, Roel Schats, Cornelis B Lambalk
BACKGROUND/AIM: To compare the pregnancy outcome of singletons conceived after transfer of cryopreserved and thawed embryos (frozen embryo transfer [FET]) to singletons conceived after fresh embryo transfer (fresh ET) and natural conceived singletons. METHODS: Using a retrospective data analysis on a study population consisting of 1,261 singletons born after FET and 2,519 singletons born after fresh ET between 2006 and 2015. The control group consisted of singletons born after natural conception...
May 13, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28496018/effects-of-heat-stress-on-bovine-preimplantation-embryos-produced-in-vitro
#7
Miki Sakatani
Summer heat stress decreases the pregnancy rate in cattle and has been thought to be associated with the early embryonic death caused by the elevation of maternal body temperature. In vitro cultures have been widely used for the evaluation of effects of heat stress on oocytes, fertilization, preimplantation, and embryonic development. Susceptibility to heat stress is present in developmental stages from oocytes to cleavage-stage (before embryonic gene activation, EGA) embryos, leading to a consequent decrease in developmental competence...
May 12, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28480049/discrete-survival-model-analysis-of-a-couple-s-smoking-pattern-and-outcomes-of-assisted-reproduction
#8
Jose C Vanegas, Jorge E Chavarro, Paige L Williams, Jennifer B Ford, Thomas L Toth, Russ Hauser, Audrey J Gaskins
BACKGROUND: Cigarette smoking has been associated with worse infertility treatment outcomes, yet some studies have found null or inconsistent results. METHODS: We followed 225 couples who underwent 354 fresh non-donor assisted reproductive technology (ART) cycles between 2006 and 2014. Smoking history was self-reported at study entry. We evaluated the associations between smoking patterns and ART success using multivariable discrete time Cox proportional hazards models with six time periods: cycle initiation to egg retrieval, retrieval to fertilization, fertilization to embryo transfer (ET), ET to implantation, implantation to clinical pregnancy, and clinical pregnancy to live birth to estimate hazard ratios (HR) and 95% CIs...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/28479126/low-serum-concentration-in-bovine-embryo-culture-enhances-early-blastocyst-rates-on-day-6-with-quality-traits-in-the-expanded-blastocyst-stage-similar-to-bsa-cultured-embryos
#9
A Murillo, M Muñoz, D Martín-González, S Carrocera, A Martínez-Nistal, E Gómez
In bovine, single in vitro embryo culture in protein-free medium from Day-6 to Day-7 leads to expanded blastocyst (XB) with improved pregnancy and birth rates after cryopreservation. Under these conditions, early blastocysts (EB) progress to the XB stage at higher rates than morulae (M). However, embryo production with BSA in culture prior to Day-6 leads to low EB rates. We investigated whether a very low FCS concentration (0.1%) in culture from Day-1 to Day-6 would improve EB rates and, subsequently, increase XB rates on Day-7 after single culture in protein-free medium...
May 4, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28476486/the-effect-of-endometrial-scratch-on-natural-cycle-cryopreserved-embryo-transfer-outcomes-a-randomized-controlled-study
#10
Jennifer Sze Man Mak, Cathy Hoi Sze Chung, Jacqueline Pui Wah Chung, Grace Wing Shan Kong, Sotirios H Saravelos, Lai Ping Cheung, Tin-Chiu Li
The benefit of endometrial scratch (ES) prior to embryo transfer is controversial. Systemic analysis has confirmed its potential benefit, especially in women with repeated IVF failures, yet most studies have focused on fresh embryo transfer, and its effect on vitrified-warmed embryo transfer (FET) cycles is yet to be explored. We hereby present our prospective, double-blind, randomized controlled study on the evaluation of the implantation and pregnancy rate after ES prior to natural-cycle FET. A total of 299 patients underwent natural-cycle FET and were randomized to receive ES (n = 115) or endocervical manipulation as control (n = 114) prior to FET cycle, and a total of 196 patients had embryo transfer (93 patients in each group)...
April 19, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28472983/comparative-neonatal-outcomes-in-singleton-births-from-blastocyst-transfers-or-cleavage-stage-embryo-transfers-a-systematic-review-and-meta-analysis
#11
REVIEW
Xingling Wang, Mingze Du, Yichun Guan, Bijun Wang, Junwei Zhang, Zihua Liu
BACKGROUND: Comparative neonatal outcomes with respect to singleton births from blastocyst transfers or cleavage-state embryo transfers are controversial with respect to which method is superior. Many studies have yielded contradictory results. We performed a systematic review and meta-analysis for the purpose of comparing neonatal outcomes in single births following IVF/ICSI. METHODS: We searched the Medline, Embase and Cochrane Central Register of Clinical Trials (CCTR) databases until October 2016...
May 4, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28472321/high-fsh-dosing-is-associated-with-reduced-live-birth-rate-in-fresh-but-not-subsequent-frozen-embryo-transfers
#12
Erika M Munch, Amy E Sparks, M Bridget Zimmerman, Bradley J Van Voorhis, Eyup Hakan Duran
STUDY QUESTION: Do live birth rates (LBRs) differ between fresh embryo transfer (fresh ET) cycles and their subsequent paired frozen ET (FET) cycles, when comparing cycles based on the total FSH dose used during the fresh cycle? SUMMARY ANSWER: When compared to the paired frozen embryo transfer cycles, the LBR in the fresh cycle of the highest total FSH dose group (>2500 IU) was reduced by 38%. WHAT IS KNOWN ALREADY: There may be a negative association with high gonadotropin doses and LBR after fresh ET...
May 3, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28460276/cost-effectiveness-of-single-versus-double-embryo-transfer-in-ivf-in-relation-to-female-age
#13
Laura L van Loendersloot, Lobke M Moolenaar, Madelon van Wely, Sjoerd Repping, Patrick M Bossuyt, Peter G A Hompes, Fulco van der Veen, Ben Willem J Mol
OBJECTIVE: To evaluate the cost-effectiveness of single embryo transfer followed by an additional frozen-thawed single embryo transfer, if more embryos are available, as compared to double embryo transfer in relation to female age. STUDY DESIGN: We used a decision tree model to evaluate the costs from a healthcare provider perspective and the pregnancy rates of two embryo transfer policies: one fresh single embryo transfer followed by an additional frozen-thawed single embryo transfer, if more embryos are available (strategy I), and double embryo transfer (strategy II)...
April 17, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28457554/comparison-between-an-exclusive-in-vitro-produced-embryo-transfer-system-and-artificial-insemination-for-genetic-technical-and-financial-herd-performance
#14
K Kaniyamattam, J Block, P J Hansen, A De Vries
The objective of this study was to implement an in vitro produced embryo transfer (IVP-ET) system in an existing stochastic dynamic dairy simulation model with multitrait genetics to evaluate the genetic, technical, and financial performance of a dairy herd implementing an exclusive IVP-ET or artificial insemination (AI) system. In the AI system, sexed semen was used on the genetically best heifers only. In the IVP-ET system, all of the animals in the herd were impregnated with female sexed embryos created through in vitro fertilization of oocytes collected from animals of superior genetics for different traits of interest...
April 27, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28455751/national-trends-and-outcomes-of-autologous-in-vitro-fertilization-cycles-among-women-ages-40-years-and-older
#15
Heather Hipp, Sara Crawford, Jennifer F Kawwass, Sheree L Boulet, David A Grainger, Dmitry M Kissin, Denise Jamieson
PURPOSE: The purpose of the study was to describe trends in and investigate variables associated with clinical pregnancy and live birth in autologous in vitro fertilization (IVF) cycles among women ≥40 years. METHODS: We used autologous IVF cycle data from the National ART Surveillance System (NASS) for women ≥40 years at cycle start. We assessed trends in fresh and frozen cycles (n = 371,536) from 1996 to 2013. We reported perinatal outcomes and determined variables associated with clinical pregnancy and live birth in fresh cycles between 2007 and 2013...
April 28, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28448636/successful-vitrification-of-pronuclear-stage-pig-embryos-with-a-novel-cryoprotective-agent-carboxylated-%C3%AE%C2%B5-poly-l-lysine
#16
Maki Kamoshita, Tsubasa Kato, Katsuyoshi Fujiwara, Takafumi Namiki, Kazuaki Matsumura, Suong-Hyu Hyon, Junya Ito, Naomi Kashiwazaki
Vitrification is a powerful tool for the efficient production of offspring derived from cryopreserved oocytes or embryos in mammalian species including domestic animals. Genome editing technologies such as transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR-associated (Cas)9 are now available even for domestic species, suggesting that the vitrification of embryos at the pronuclear stage (PN) will be more important because they could provide genomic host cells to be targeted by TALENs or CRISPR/Cas9...
2017: PloS One
https://www.readbyqxmd.com/read/28447502/the-effect-of-endometrial-injury-on-implantation-and-clinical-pregnancy-rates
#17
Dan Levin, Joseph Hasson, Aviad Cohen, Yuval Or, Baris Ata, Lilia Barzilay, Benny Almog
AIM: To assess the effect of endometrial scratching (ES) on in vitro fertilization-embryo transfer outcome (IVF-ET) Materials and methods: Retrospective matched case control study including all fresh IVF cycles performed between January 2006 and December 2012 at an academic IVF center. ES with an endometrial biopsy catheter was performed in the cycle preceding the index IVF cycle. Patients (n = 238) were pair matched with controls according to age, number of previous failed IVF cycles and number of embryos transferred...
April 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28444613/no-difference-in-congenital-anomalies-prevalence-irrespective-of-insemination-methods-and-freezing-procedure-cohort-study-over-fourteen-years-of-an-art-population-in-the-south-of-france
#18
Any Beltran Anzola, Vanessa Pauly, Debbie Montjean, Line Meddeb, Cendrine Geoffroy-Siraudin, Roland Sambuc, Pierre Boyer, Marie-José Gervoise-Boyer
PURPOSE: A retrospective cohort study was conducted to evaluate and compare the prevalence of congenital anomalies in babies and fetuses conceived after four procedures of assisted reproduction technologies (ART). METHODS: The prevalence of congenital anomalies was compared retrospectively between 2750 babies and fetuses conceived between 2001 and 2014 in vitro fertilization with standard insemination (IVF), IVF with intracytoplasmic sperm injection (ICSI), IVF with frozen embryo transfer (FET-IVF), and ICSI with frozen embryo transfer (FET-ICSI)...
March 23, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28440686/severe-ovarian-hyperstimulation-syndrome-after-combined-gnrh-agonist-and-low-dose-human-chorionic-gonadotropin-trigger-in-a-patient-with-a-single-kidney
#19
Nigel Pereira, Jovana P Lekovich, Isaac Kligman, Zev Rosenwaks
Ovarian hyperstimulation syndrome (OHSS) following gonadotropin-releasing hormone agonist (GnRH-a) trigger is rare. Here, we report a case of severe OHSS after combined GnRH-a and low-dose human chorionic gonadotropin (hCG) trigger in a patient with a single kidney. The patient is a 32-year-old women with a two-year history of infertility. The patient's history was significant for a single kidney, that is, she had donated a kidney to a family member three years ago. The patient underwent controlled ovarian stimulation (COS) for in vitro fertilization (IVF) and received a combined 2 mg GnRH-a and 1500 IU hCG ovulatory trigger...
April 25, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28438181/efficient-vitrification-of-mouse-embryos-using-the-kitasato-vitrification-system-as-a-novel-vitrification-device
#20
Kenji Momozawa, Atsushi Matsuzawa, Yukio Tokunaga, Shiori Abe, Yumi Koyanagi, Miho Kurita, Marina Nakano, Takao Miyake
BACKGROUND: Currently, the cryopreservation of embryos and oocytes is essential for assisted reproductive technology (ART) laboratories worldwide. This study aimed to evaluate the efficacy of the Kitasato Vitrification System (KVS) as a vitrification device for the cryopreservation of mouse embryos to determine whether this novel device can be adapted to the field of ART. METHODS: In Experiment 1, blastocysts were vitrified using the KVS. Vitrified blastocysts were warmed and subsequently cultured for 72 h...
April 24, 2017: Reproductive Biology and Endocrinology: RB&E
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