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Rui Hu, Zhiwei Wang, Zongli Ren, Min Liu
BACKGROUND: Epidemiological studies reported that diabetic patients had a lower incidence of aortic dissection (AD), but the definite mechanism is unknown. We aim to investigate the possible protective effect of diabetes mellitus (DM) on AD formation with an emphasis on autonomic remodeling. METHODS: Streptozotocin (STZ) intraperitoneal injection was applied to induce diabetes, unilateral renal artery stenosis (URAS) together with β-amino propionitrile (BAPN) oral treatment was used to induce AD...
October 21, 2016: BMC Cardiovascular Disorders
Fujiko Mitsumoto-Kaseida, Masayuki Murata, Kazuya Ura, Koji Takayama, Satoshi Hiramine, Motohiro Shimizu, Kazuhiro Toyoda, Eiichi Ogawa, Norihiro Furusyo
CD64 is an Fc-gamma-receptor type 1. The expression level of neutrophil CD64 (nCD64) is a known bacterial infection marker, and it also increases in viral infections. We examined the absolute nCD64 before and after the initiation of antiretroviral therapy (ART) to determine its role as an infection and inflammation marker of human immunodeficiency virus (HIV) infection. In this prospective observational study, ninety-four HIV infected patients were enrolled and classified into ART (n=62), ART naive (n=24), and acute/early phase groups (n=8)...
October 20, 2016: AIDS Research and Human Retroviruses
Reina Shimokawa, Yumi Kawada, Miki Hayashi, Yasutaka Kataoka, Yasuyuki Ura
A cationic SNS-benzylpalladium complex was reacted with O2 under several conditions, affording oxygenated compounds derived from the benzyl ligand. The addition of n-Bu4NX remarkably accelerated the oxygenation, furnishing benzaldehyde as a main organic product and dinuclear complexes; in contrast, HX also promoted the oxygenation, but mainly produced benzyl hydroperoxide and mononuclear complexes.
October 18, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Seiya Urae, Kayori Tsuruoka, Sayaka Kuroya, Yugo Shibagaki
Tumor lysis syndrome (TLS) is a metabolic disorder that is generally associated with a malignancy leading to hyperuricemia, hyperphosphatemia, and acute kidney injury. On the other hand, we sometimes encounter these phenomena in nonmalignant disease, which has been referred to as tumor lysis-like syndrome in some studies. We herein experienced a case in which tumor lysis-like syndrome occurred in the course of therapy for eosinophilic disease of the lung, a nonmalignant disease. Even in nonmalignant disease, massive cell lysis induced by therapy can cause phenomena such as TLS or tumor lysis-like syndrome...
2016: Internal Medicine
Chelsea Starbuck, Victoria Stiles, Daniel Urà, Matt Carré, Sharon Dixon
OBJECTIVES: To examine the influence of clay court frictional properties on tennis players' biomechanical response. DESIGN: Repeated measures. METHODS: Lower limb kinematic and force data were collected on sixteen university tennis players during 10×180° turns (running approach speed 3.9±0.20ms(-1)) on a synthetic clay surface of varying friction levels. To adjust friction levels the volume of sand infill above the force plate was altered (kg per m(2) surface area; 12, 16 and 20kgm(-2))...
September 1, 2016: Journal of Science and Medicine in Sport
Recep Vatansever, Mehmet Emin Uras, Ugur Sen, Ibrahim Ilker Ozyigit, Ertugrul Filiz
A transcription factor DREB1A (dehydration-responsive element-binding 1A) gene was amplified and sequenced from the common bean (Phaseolus vulgaris). PvDREB1A had a 777 base pairs (bp) open reading frame encoding a protein of 225 residues. The protein sequence contained a conserved DNA-binding AP2 domain of about 60 residues and a nuclear localization signal (NLS) at N-terminus site. PvDREB1A demonstrated high homology with other DREB1 members only in AP2 domain and NLS site. The phylogenetic distribution of different DREB members showed three main groups as DREB1-3 and PvDREB1A was a member of DREB1 group...
October 14, 2016: Journal of Biomolecular Structure & Dynamics
Toshiki Masuishi, Hiroya Taniguchi, Satoshi Hamauchi, Azusa Komori, Yosuke Kito, Yukiya Narita, Takahiro Tsushima, Makoto Ishihara, Akiko Todaka, Tsutomu Tanaka, Tomoya Yokota, Shigenori Kadowaki, Nozomu Machida, Takashi Ura, Akira Fukutomi, Masashi Ando, Yusuke Onozawa, Masahiro Tajika, Hirofumi Yasui, Kei Muro, Keita Mori, Kentaro Yamazaki
BACKGROUND: Regorafenib and trifluridine/tipiracil (TAS-102) both prolong survival for patients with refractory metastatic colorectal cancer. However, it is unclear which drug should be administered first. MATERIALS AND METHODS: We retrospectively evaluated the data from patients who had received regorafenib or TAS-102 at 2 institutions from May 2013 to March 2015. The inclusion criteria were disease refractory or intolerant to fluoropyrimidines, oxaliplatin, irinotecan, anti-vascular endothelial growth factor antibodies, and anti-epidermal growth factor receptor (EGFR) antibodies (if KRAS exon 2 wild-type), and no previous treatment with regorafenib or TAS-102...
August 31, 2016: Clinical Colorectal Cancer
Hirotoshi Niikawa, Tsuyoshi Okamura, Kae Ito, Chiaki Ura, Fumiko Miyamae, Naoko Sakuma, Mutsuo Ijuin, Hiroki Inagaki, Mika Sugiyama, Shuichi Awata
AIM: Polypharmacy is a serious medical problem among older adults. Polypharmacy can cause adverse drug reactions and is associated with frailty. Several drugs, particularly psychotropic medications, can cause cognitive impairment. Recent research also suggests that polypharmacy can cause cognitive impairment. We investigated the prevalence of polypharmacy, and examined the association between polypharmacy and cognitive impairment in a large sample of community-dwelling older adults in Japan...
September 15, 2016: Geriatrics & Gerontology International
Katsumi Ura
I investigated the tilting and movement of the objective lens of a 3D electron microscope electrically as an extension of the moving-objective lens concept. The electric or magnetic potential along the tilted optical axis is analytically expressed by a multipole potential expansion about the fixed central axis. The field distributions for axially symmetric dipole and quadrupole components are numerically shown, where the optical axis of a bell-shaped magnetic lens is tilted around the lens center by up to 60°...
October 2016: Microscopy
Shunji Takahashi, Kenji Nakano, Tomoya Yokota, Kohei Shitara, Kei Muro, Yoshinori Sunaga, Evelyne Ecstein-Fraisse, Takashi Ura
OBJECTIVE: In clinical studies in Western countries, the recommended dose of combination ombrabulin a vascular disrupting agent, with cisplatin is 25 mg/m(2) ombrabulin with 75 mg/m(2) cisplatin every 3 weeks. Here, we report the first Phase 1 study of this treatment regimen in Japanese patients with advanced solid tumors. METHODS: This was an open-label, multicenter, sequential cohort, dose-escalation Phase 1 study of ombrabulin with cisplatin administered once every 3 weeks...
August 27, 2016: Japanese Journal of Clinical Oncology
Satoshi Yamaguchi, Manami Ura, Shin Izuta, Akimitsu Okamoto
Stimuli-responsive "activatable" reactive tags are applicable to selective labeling of biomolecules in a defined area or environment in living systems, yielding new insights into cellular processes through molecular imaging and fishing. Here, we developed a chemically activatable alkyne tag that can be incorporated into biological molecules and labeled with azide-tagged functional molecules through the alkyne-azide cycloaddition "click" reaction after chemical activation. Formation of the alkyne tag from the precursor moiety was confirmed to proceed in physiological aqueous media and was particularly enhanced under mildly acidic pH...
September 21, 2016: Bioconjugate Chemistry
Satoshi Hamauchi, Kentaro Yamazaki, Toshiki Masuishi, Yosuke Kito, Azusa Komori, Takahiro Tsushima, Yukiya Narita, Akiko Todaka, Makoto Ishihara, Tomoya Yokota, Tsutomu Tanaka, Nozomu Machida, Shigenori Kadowaki, Akira Fukutomi, Takashi Ura, Yusuke Onozawa, Masashi Ando, Masahiro Tajika, Kei Muro, Hirofumi Yasui, Keita Mori, Hiroya Taniguchi
BACKGROUND: TAS-102 significantly improves overall survival in patients with metastatic colorectal cancer. The most common treatment-related adverse event of TAS-102 is bone marrow suppression, which leads to neutropenia. The potential predictive value of neutropenia caused by cytotoxic drugs has been reported in various types of cancer. METHODS: We retrospectively analyzed 95 consecutive patients with metastatic colorectal cancer who received TAS-102 at 2 Japanese institutions between May 2014 and May 2015...
July 21, 2016: Clinical Colorectal Cancer
Lihua Zhang, Xianzhong Chen, Zhen Chen, Zezheng Wang, Shan Jiang, Li Li, Markus Pötter, Wei Shen, You Fan
The diploid yeast Candida tropicalis, which can utilize n-alkane as a carbon and energy source, is an attractive strain for both physiological studies and practical applications. However, it presents some characteristics, such as rare codon usage, difficulty in sequential gene disruption, and inefficiency in foreign gene expression, that hamper strain improvement through genetic engineering. In this work, we present a simple and effective method for sequential gene disruption in C. tropicalis based on the use of an auxotrophic mutant host defective in orotidine monophosphate decarboxylase (URA3)...
August 13, 2016: Applied Microbiology and Biotechnology
Jiabing Ran, Lingjun Xie, Guanglin Sun, Jingxiao Hu, Si Chen, Pei Jiang, Xinyu Shen, Hua Tong
To date, great efforts have been made to prepare different kinds of isotropic tissue engineering (TE) scaffolds. However, little attention has been paid to anisotropic porous scaffolds in spite of many examples of their excellent performances. In this work, a facile method termed "ammonia-induced method" (AIM) was proposed and applied to generate anisotropic pores in chitosan (CS)-based scaffolds. The pore structures of these scaffolds were studied in detail. In order to clarify the rationale behind this process, a speculative explanation was provided on basis of the experimental results and the theory of Uras (Uras & Devlin, 2000)...
November 5, 2016: Carbohydrate Polymers
Rahul Gajbhiye, Kaushiki Kadam, Aalok Khole, Avinash Gaikwad, Seema Kadam, Rupin Shah, Rangaswamy Kumaraswamy, Vrinda Khole
BACKGROUND & OBJECTIVES: The role of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in congenital bilateral absence of vas deferens and unilateral renal agenesis (CBAVD-URA) has been controversial. Here, we report the cases of five Indian males with CBAVD-URA. The objective was to evaluate the presence or absence of CFTR gene mutations and variants in CBAVD-URA. The female partners of these males were also screened for cystic fibrosis (CF) carrier status. METHODS: Direct DNA sequencing of CFTR gene was carried out in five Indian infertile males having CBAVD-URA...
May 2016: Indian Journal of Medical Research
Recep Vatansever, Ibrahim Koc, Ibrahim Ilker Ozyigit, Ugur Sen, Mehmet Emin Uras, Naser A Anjum, Eduarda Pereira, Ertugrul Filiz
Solanum tuberosum genome analysis revealed 12 StSULTR genes encoding 18 transcripts. Among genes annotated at group level ( StSULTR I-IV), group III members formed the largest SULTRs-cluster and were potentially involved in biotic/abiotic stress responses via various regulatory factors, and stress and signaling proteins. Employing bioinformatics tools, this study performed genome-wide identification and expression analysis of SULTR (StSULTR) genes in potato (Solanum tuberosum L.). Very strict homology search and subsequent domain verification with Hidden Markov Model revealed 12 StSULTR genes encoding 18 transcripts...
December 2016: Planta
Naoko Sakuma, Chiaki Ura, Fumiko Miyamae, Hiroki Inagaki, Kae Ito, Hirotoshi Niikawa, Mutsuo Ijuin, Tsuyoshi Okamura, Mika Sugiyama, Shuichi Awata
OBJECTIVES: The Mini-Mental State Examination (MMSE) is widely used as a cognitive screening test for older adults; however, cognitive performance can be affected by age, education, and sample selection bias, including time and place. The aims of this study were to examine the distribution of scores on the Japanese version of the MMSE in an urban community sample and to provide normative data for older Japanese adults. METHODS: A questionnaire survey was conducted on all residents aged 65 years and older living in an urban district in Tokyo (N = 7682)...
July 18, 2016: International Journal of Geriatric Psychiatry
Osama M Sarhan, Khalid Albedaiwi, Badr Al Harbi, Abdulhakim Al Otay, Mustafa Al Ghanbar, Ziad Nakshabandi
OBJECTIVE: To assess the need for postnatal evaluation and the long term consequences in patients with prenatal diagnosis of unilateral renal agenesis (URA). MATERIALS AND METHODS: A retrospective review of the records of all patients with prenatal diagnosis of URA between 2004 and 2013 was done. We included all patients who underwent postnatal evaluation with renal bladder ultrasound (RBUS), dimercaptosuccinic acid scan (DMSA) and a voiding cystourethrogram (VCUG)...
July 12, 2016: Urology
Shinji Kobuchi, Asuka Hayashi, Mayu Taniguchi, Yukako Ito, Takao Tamura, Toshiyuki Sakaeda
PURPOSE: The options for improving the chemotherapeutic regimen consisting of bolus plus infusion of 5-fluorouracil (5-FU) include omitting the 5-FU bolus injection. We examined the effects of a 5-FU bolus injection on the activity of dihydropyrimidine dehydrogenase (DPD), which is the first and rate-limiting enzyme of 5-FU catabolism, in rats. METHODS: The rats were divided into three groups, and then continuous infusion (50 mg/m(2)/h) for 4 h was started with a bolus injection of saline, 20 mg/kg 5-FU, or 60 mg/kg 5-FU...
September 2016: Cancer Chemotherapy and Pharmacology
Shogo Ura, Masahiro Nakata, Kenichi Yanagida, Junichi Inoue, Kenji Kintaka
A cavity-resonator-integrated guided-mode resonance filter (CRIGF) consists of a grating coupler inside a pair of distributed Bragg reflectors. A combination of a CRIGF with a high-reflection substrate can provide a new type of a band-stop reflector with a small aperture for a vertically incident wave from air. A narrow stopband was theoretically predicted and experimentally demonstrated. It was quantitatively shown that reflection spectra depended on optical-buffer-layer thickness. The reflector of 10-μm aperture was fabricated and characterized...
June 27, 2016: Optics Express
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