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https://www.readbyqxmd.com/read/28157071/association-between-and-polymorphisms-and-adverse-drug-reactions-to-regorafenib-a-preliminary-study%C3%A2
#1
Akimitsu Maeda, Hitoshi Ando, Takashi Ura, Azusa Komori, Ayako Hasegawa, Hiroya Taniguchi, Shigenori Kadowaki, Kei Muro, Masahiro Tajika, Makiko Kobara, Masahide Matsuzaki, Naoya Hashimoto, Mieko Maeda, Yasushi Kojima, Masahiro Aoki, Eisaku Kondo, Akiyoshi Mizutani, Akio Fujimura
OBJECTIVE: Due to the occurrence of severe adverse drug reactions to regorafenib, a drug used in cancer therapy, the identification of a predictive marker(s) is needed to increase the therapeutic applicability of this compound. We therefore investigated whether polymorphisms in the ABCG2 and SLCO1B genes are associated with adverse drug reactions to regorafenib. METHODS: For these analyses, 37 Japanese cancer patients were treated with regorafenib, genotyped for polymorphisms in ABCG2 and SLCO1B, and evaluated for drug-related adverse drug reactions...
February 3, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28150505/reference-intervals-for-growth-arrest-specific-6-protein-in-adults
#2
Zeynep Cagman, Ozlem Bingol Ozakpinar, Zeynep Cirakli, Asuman Gedikbasi, Pinar Ay, David Colantonio, Ahmet Riza Uras, Khosrow Adeli, Fikriye Uras
The objective of this study was to establish reference intervals for growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, in human adult plasma according to the Guideline of Clinical and Laboratory Standards Institute (CLSI) C28-A3. Blood samples were collected from 308 healthy volunteers aged 18-72 (157 female, 151 male). A non-parametric approach was used to calculate the reference interval. The plasma GAS6 reference interval was determined, with 90% confidence interval: the lower limit (2.5 percentile) was 2...
April 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28142137/efficacy-of-second-line-bevacizumab-containing-chemotherapy-for-patients-with-metastatic-colorectal-cancer-following-first-line-treatment-with-an-anti-epidermal-growth-factor-receptor-antibody
#3
Hiroko Hasegawa, Hiroya Taniguchi, Seiichiro Mitani, Toshiki Masuishi, Azusa Komori, Yukiya Narita, Shigenori Kadowaki, Takashi Ura, Masashi Ando, Yasushi Yatabe, Kei Muro
OBJECTIVE: Anti-epidermal growth factor receptor (EGFR) antibodies and bevacizumab are commonly used, sequentially, as palliative chemotherapies for patients with metastatic colorectal cancer. However, little is known about the efficacy of second-line treatments containing bevacizumab after first-line treatment with an anti-EGFR antibody. METHODS: We retrospectively reviewed 128 patients who received second-line bevacizumab-containing chemotherapy and evaluated the effect of prior use of anti-EGFR antibody on the efficacy of the second-line treatment...
February 1, 2017: Oncology
https://www.readbyqxmd.com/read/28117375/chemically-activatable-alkyne-tagged-probe-for-imaging-microdomains-in-lipid-bilayer-membranes
#4
Satoshi Yamaguchi, Taku Matsushita, Shin Izuta, Sumika Katada, Manami Ura, Taro Ikeda, Gosuke Hayashi, Yuta Suzuki, Koya Kobayashi, Kyoya Tokunaga, Yasuyuki Ozeki, Akimitsu Okamoto
A chemically-activatable alkynyl steroid analogue probe has been synthesized for visualizing the lipid raft membrane domains by Raman microscopy. The Raman probe, in which ring A of its steroid backbone is replaced with an alkynyl group, was designed to enable activation of the alkyne signal through the Eschenmoser-Tanabe fragmentation reaction of the oxidized cholesterol precursor in lipid bilayer membranes. The alkynyl steroid analogue was observed to form liquid-ordered raft-like domains on a model giant-liposome system in a similar manner as cholesterol, and the large alkyne signal of the accumulated probe at 2120 cm(-1) was mapped on the microdomains with a Raman microscope...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28116939/pomalidomide-in-heavily-pretreated-refractory-multiple-myeloma-a-case-report
#5
Angelo Palmas, Giovanna Piras, Antonella Uras, Rosanna Asproni, Marco Murineddu, Maria Monne, Roberta Stradoni, Giancarlo Latte
We present the case of a 70-year-old man diagnosed with multiple myeloma in 2008, who after four therapy lines initiated a fifth-line treatment with pomalidomide (4 mg orally, days 1-21 of a 28-day cycle) and low-dose dexamethasone (40 mg weekly orally). The patient was treated with pomalidomide for almost 2 years achieving a complete remission after 12 cycles. Complete remission was maintained for 9 months. This case illustrates the potential of pomalidomide plus low-dose dexamethasone to overcome multiple myeloma refractoriness inducing a quick and very prolonged remission...
February 2017: Future Oncology
https://www.readbyqxmd.com/read/28108278/comparison-of-the-redox-chemistry-of-sulfur-and-selenium-containing-analogs-of-uracil
#6
N Connor Payne, Andrew Geissler, Aileen Button, Alexandru R Sasuclark, Alayne L Schroll, Erik L Ruggles, Vadim N Gladyshev, Robert J Hondal
Selenium is present in proteins in the form of selenocysteine, where this amino acid serves catalytic oxidoreductase functions. The use of selenocysteine in nature is strongly associated with redox catalysis. However, selenium is also found in a 2-selenouridine moiety at the wobble position of tRNA(Glu), tRNA(Gln) and tRNA(Lys). It is thought that the modifications of the wobble position of the tRNA improves the selectivity of the codon-anticodon pair as a result of the physico-chemical changes that result from substitution of sulfur and selenium for oxygen...
January 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28077650/melanin-or-melanin-like-substance-interacts-with-the-n-terminal-portion-of-prion-protein-and-inhibits-abnormal-prion-protein-formation-in-prion-infected-cells
#7
Taichi Hamanaka, Keiko Nishizawa, Yuji Sakasegawa, Ayumi Oguma, Kenta Teruya, Hiroshi Kurahashi, Hideyuki Hara, Suehiro Sakaguchi, Katsumi Doh-Ura
Prion diseases are progressive fatal neurodegenerative illnesses caused by the accumulation of transmissible abnormal prion protein (PrP). To find treatments for prion diseases, we searched for substances from natural resources that inhibit abnormal PrP formation in prion-infected cells. We found that high-molecular-weight components from insect cuticle extracts reduced abnormal PrP levels. The chemical nature of these components was consistent with that of melanin. In fact, synthetic melanin produced from tyrosine or 3-hydroxy-l-tyrosine inhibited abnormal PrP formation...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28058527/outcomes-of-a-phase-i-ii-trial-of-hepatic-arterial-infusion-of-oxaliplatin-combined-with-intravenous-5-fluorouracil-and-l-leucovorin-in-patients-with-unresectable-liver-metastases-from-colorectal-cancer-after-systemic-chemotherapy-failure
#8
Yozo Sato, Yoshitaka Inaba, Takashi Ura, Hideyuki Nishiofuku, Hidekazu Yamaura, Mina Kato, Daisuke Takahari, Toshihiro Tanaka, Kei Muro
PURPOSE: The purpose of this study was to assess hepatic arterial infusion (HAI) of oxaliplatin combined with intravenous 5-fluorouracil (5-FU) and l-leucovorin (l-LV) in colorectal cancer (CRC) patients with systemic chemotherapy failure in a phase I/II trial. METHODS: CRC patients with unresectable liver metastases following standard systemic chemotherapy failure were eligible. A catheter-port system for HAI was placed using interventional radiology. In phase I, escalating doses of oxaliplatin for levels 1 and 2 were set at 50 and 100 mg/m(2), respectively, and were combined with fixed doses of intravenous 5-FU (200 mg/m(2) bolus and 2400 mg/m(2)/46-h continuous infusion) and l-LV (200 mg/m(2))...
January 6, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28011993/putative-orotate-transporter-of-cryptococcus-neoformans-oat1-is-a-member-of-the-ncs1-prt-transporter-super-family-and-its-loss-causes-attenuation-of-virulence
#9
Akio Toh-E, Misako Ohkusu, Kiminori Shimizu, Azusa Takahashi-Nakaguchi, Susumu Kawamoto, Naruhiko Ishiwada, Akira Watanabe, Katsuhiko Kamei
It is well known that 5-fluoroorotic acid (5-FOA)-resistant mutants isolated from wild-type Cryptococcus neoformans are exclusively either ura3 or ura5 mutants. Unexpectedly, many of the 5-FOA-resistant mutants isolated in our selective regime were Ura(+). We identified CNM00460 as the gene responsible for these mutations. Cnm00460 belongs to the nucleobase cation symporter 1/purine-related transporter (NCS1/PRT) super family of fungal transporters, representative members of which are uracil transporter, uridine transporter and allantoin transporter of Saccharomyces cerevisiae...
December 23, 2016: Current Genetics
https://www.readbyqxmd.com/read/28011507/platinum-based-doublet-chemotherapy-for-advanced-gastric-cancer-with-disseminated-intravascular-coagulation
#10
Keiji Sugiyama, Yukiya Narita, Shigenori Kadowaki, Takashi Ura, Masahiro Tajika, Kei Muro
BACKGROUND: Disseminated intravascular coagulation (DIC) is a rare complication of advanced gastric cancer (AGC). Despite reports of the efficacy of chemotherapy for AGC with DIC, little is known of platinum-based doublet therapy. PATIENTS AND METHODS: We conducted a single-institute, retrospective chart review of 500 consecutive chemotherapy-naïve patients with advanced gastric adenocarcinoma (recurrent or metastatic) from November 2010 to November 2015. RESULTS: Six patients were diagnosed with AGC with DIC (1...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28007921/mosquito-behaviour-change-after-distribution-of-bednets-results-in-decreased-protection-against-malaria-exposure
#11
Edward K Thomsen, Gussy Koimbu, Justin Pulford, Sharon Jamea-Maiasa, Yangta Ura, John B Keven, Peter M Siba, Ivo Mueller, Manuel W Hetzel, Lisa J Reimer
BACKGROUND: Behavioural resilience in mosquitoes poses a significant challenge to mosquito control. Although behaviour changes in anopheline vectors have been reported over the last decade, there are no empirical data to suggest they compromise the efficacy of vector control in reducing malaria transmission. METHODS: In this study, we quantified human exposure to both bites and infective bites of a major malaria vector in Papua New Guinea over the course of four years surrounding a nationwide bednet distribution...
December 22, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27993015/cytosolic-transport-of-nanoparticles-through-pressurized-plasma-membranes-for-molecular-delivery-and-amplification-of-intracellular-fluorescence
#12
Yoshihisa Kaizuka, Tomoto Ura, Shaowei Lyu, Ling Chao, Joel Henzie, Hidenobu Nakao
Transporting nanoparticles into live cells is important for drug delivery and other related applications. We found that cells exposed to hypoosmotic pressures can internalize substantial quantities of gold nanoparticles. Importantly, these nanoparticles can circumvent normal intracellular traffic and be transported directly into the cytosol, without the need for surface functionalization. In contrast, nanoparticles endocytosed at physiological osmolality are segregated inside endocytic organelles and are not able to reach the cytosol...
December 20, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27984841/does-circadian-variation-of-mothers-affect-macronutrients-of-breast-milk
#13
Aslihan Köse Çetinkaya, Evrim Alyamaç Dizdar, Erbu Yarcı, Fatma Nur Sari, Serife Suna Oguz, Nurdan Uras, Fuat Emre Canpolat
Objective To determine the within-day variation of fat, protein, and carbohydrate content of breast milk. Methods The study was conducted at Zekai Tahir Burak Maternity Teaching Hospital between April 2013 and January 2014. We obtained milk samples from lactating mothers of hospitalized infants through hand expression after breast-feeding or pumping three times a day. A mid-infrared human milk analyzer was used for measuring the macronutrient contents of breast milk samples. Results Lactating mothers of 52 infants (30 preterm, 22 term) were recruited to the study...
December 16, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27983836/ammoniated-complexes-of-uracil-and-transition-metal-ions-structures-of-m-ura-h-ura-nh3-by-irmpd-spectroscopy-and-computational-methods-m-fe-co-ni-cu-zn-cd
#14
Barry Power, Steven Rowe, Travis D Fridgen
The structures of deprotonated d-block metal dication bound uracil dimers, solvated by a single ammonia molecule, were explored in the gas phase using infrared multiple photon dissociation (IRMPD) spectroscopy in a Fourier transform ion cyclotron resonance-mass spectrometer. The IRMPD spectra were then compared with computed IR spectra for various isomers. Calculations were performed using B3LYP with the 6-31+G(d,p) basis set for all atoms, with the exception of Cd, for which the LANL2DZ basis set with relativistic core potentials was used...
December 29, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27978476/does-maternal-psychological-distress-affect-neurodevelopmental-outcomes-of-preterm-infants-at-a-gestational-age-of-%C3%A2-32weeks
#15
Ozlem Bozkurt, Zeynep Eras, Fatma Nur Sari, Evrim Alyamac Dizdar, Nurdan Uras, Fuat Emre Canpolat, Serife Suna Oguz
BACKGROUND: There is some evidence that maternal psychological status in the prenatal and postnatal periods is associated with infants' cognitive, behavioural, and emotional functions. AIM: The aim of this study was to examine the relationships of maternal depression and anxiety with neurodevelopmental outcomes of preterm infants with a gestational age of ≤32weeks, examined at a corrected age of 18 to 22months. STUDY DESIGN: Cross-sectional study...
December 12, 2016: Early Human Development
https://www.readbyqxmd.com/read/27973543/intradermal-delivery-of-antigens-enhances-specific-igg-and-diminishes-ige-production-potential-use-for-vaccination-and-allergy-immunotherapy
#16
Takuwa Yasuda, Takehiro Ura, Masaru Taniguchi, Hisahiro Yoshida
Skin is protected by a tough but flexible multilayered barrier and is a front line for immune responses against invading particles. For many years now, skin has been a tissue where certain vaccines are injected for the prevention of infectious disease, however, the detailed mechanisms of the skin immune response are not yet well understood. Using thin and small injection needles, we carefully injected OVA into a restricted region of mouse skin, i.e., intradermal (ID), and examined the antibody response in comparison with subcutaneous (SC) injection or epicutaneous patch administration of OVA...
2016: PloS One
https://www.readbyqxmd.com/read/27973536/a-single-subcutaneous-injection-of-cellulose-ethers-administered-long-before-infection-confers-sustained-protection-against-prion-diseases-in-rodents
#17
Kenta Teruya, Ayumi Oguma, Keiko Nishizawa, Maki Kawata, Yuji Sakasegawa, Hiroshi Kamitakahara, Katsumi Doh-Ura
Prion diseases are fatal, progressive, neurodegenerative diseases caused by prion accumulation in the brain and lymphoreticular system. Here we report that a single subcutaneous injection of cellulose ethers (CEs), which are commonly used as inactive ingredients in foods and pharmaceuticals, markedly prolonged the lives of mice and hamsters intracerebrally or intraperitoneally infected with the 263K hamster prion. CEs provided sustained protection even when a single injection was given as long as one year before infection...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27922010/mek-inhibitors-block-growth-of-lung-tumours-with-mutations-in-ataxia-telangiectasia-mutated
#18
Michal Smida, Ferran Fece de la Cruz, Claudia Kerzendorfer, Iris Z Uras, Barbara Mair, Abdelghani Mazouzi, Tereza Suchankova, Tomasz Konopka, Amanda M Katz, Keren Paz, Katalin Nagy-Bojarszky, Markus K Muellner, Zsuzsanna Bago-Horvath, Eric B Haura, Joanna I Loizou, Sebastian M B Nijman
Lung cancer is the leading cause of cancer deaths, and effective treatments are urgently needed. Loss-of-function mutations in the DNA damage response kinase ATM are common in lung adenocarcinoma but directly targeting these with drugs remains challenging. Here we report that ATM loss-of-function is synthetic lethal with drugs inhibiting the central growth factor kinases MEK1/2, including the FDA-approved drug trametinib. Lung cancer cells resistant to MEK inhibition become highly sensitive upon loss of ATM both in vitro and in vivo...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27917816/effect-of-ankaferd-blood-stopper-on-muscle-healing
#19
Murat Uygun, Osman Y Yavuz, İsmail Uraş, İbrahim G Duman, Hacer Haltaş, Mahmut Kömürcü
PURPOSE: Ankaferd Blood Stopper (ABS), which is a standardized mixture of herbal extracts obtained from five plants, has been proven as an efficient hemostatic agent and is still used in emergency situations. It is not known exactly if decreased bleeding has positive or negative effects on muscle healing and fibrosis, so the purpose of this study was to test the effect of ABS on muscle healing and morphology. METHODS: A total of 66 outbred Wistar rats were divided into three control and three experimental subgroups...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27904878/de-novo-pyrimidine-biosynthesis-connects-cell-integrity-to-amphotericin-b-susceptibility-in-cryptococcus-neoformans
#20
Dithi Banerjee, Timothy C Umland, John C Panepinto
The use of amphotericin B (AmB) in conjunction with 5-fluorocytosine (5-FC) is known to be the optimal therapy for treating cryptococcosis, but the mechanism by which 5-FC synergizes with AmB is unknown. In this study, we generated a Cryptococcus neoformans ura1Δ mutant lacking dihydroorotate dehydrogenase (DHODH), which demonstrated temperature-sensitive growth due to a defect in cell integrity and sensitivity to cell wall-damaging agents. In addition, sensitivity to AmB was greatly increased. Inclusion of uracil or uridine in the medium did not suppress the cell wall or AmB phenotype, whereas complementation with the wild-type URA1 gene complemented the mutant phenotype...
November 2016: MSphere
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