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https://www.readbyqxmd.com/read/29719740/abscopal-effect-in-a-stage-iv-melanoma-patient-who-progressed-on-pembrolizumab
#1
James M Tsui, Catalin Mihalcioiu, Fabio L Cury
In this case report, we present the clinical course of a woman with locally advanced mucosal melanoma of the oral cavity. She was initially treated with surgery with adjuvant local radiation of 50 Gy in 20 fractions. She quickly relapsed with an aggressive regional recurrence of the disease on the neck and with numerous pulmonary metastases. Immunotherapy with pembrolizumab was started, with initial good response and reduction in the size of the lesion in the neck. The regression, however, was short-lived, as the mass quickly grew at a remarkable rate and the lung lesions progressed significantly...
February 27, 2018: Curēus
https://www.readbyqxmd.com/read/29709185/phosphorescence-kinetics-of-singlet-oxygen-produced-by-photosensitization-in-spherical-nano-particles-part-ii-the-case-of-hypericin-loaded-ldl-particles
#2
Shubhashis Datta, Andrej Hovan, Annamária Jutkova, Sergei G Kruglik, Daniel Jancura, Pavol Miskovsky, Gregor Bano
The phosphorescence kinetics of singlet oxygen produced by photosensitized hypericin (Hyp) molecules inside low-density lipoprotein (LDL) particles was studied experimentally and by means of numerical and analytical modelling. The phosphorescence signal was measured after short laser pulse irradiation of aqueous Hyp/LDL solutions. The Hyp triplet state lifetime determined by a laser flash-photolysis measurement was 5.3×10-6 s. The numerical and the analytical model described in Part-I of the present work were used to analyze the observed phosphorescence kinetics of singlet oxygen...
April 30, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29697477/utility-scores-and-preferences-for-surgical-and-organ-sparing-approaches-for-treatment-of-intermediate-and-high-risk-rectal-cancer
#3
Alice M Couwenberg, Martijn P W Intven, Johannes P M Burbach, Marleen J Emaus, Wilhelmina M U van Grevenstein, Helena M Verkooijen
BACKGROUND: Organ-sparing approaches, including wait-and-see and local excision, are increasingly being offered to patients with rectal cancer following a good response to neoadjuvant therapy. Preferences regarding these treatment strategies are yet unknown. OBJECTIVE: This study aimed to determine the preferences and utility scores for rectal cancer treatment approaches. DESIGN: This is a cross-sectional study. SETTING: This study was conducted at the Radiation-Oncology Department of the University Medical Center Utrecht...
April 24, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29693501/improving-research-in-radiation-oncology-through-interdisciplinary-collaboration
#4
Jay W Burmeister, Monica W Tracey, Sara E Kacin, Michael M Dominello, Michael C Joiner
The contribution of radiation oncology to the future of cancer treatment depends significantly on our continued clinical progress and future research advancements. Such progress relies on multidisciplinary collaboration among radiation oncologists, medical physicists and radiobiologists. Cultivating collaborative educational and research opportunities among these three disciplines and further investing in the infrastructure used to train both clinicians and researchers will therefore help us improve the future of cancer care...
April 25, 2018: Radiation Research
https://www.readbyqxmd.com/read/29670787/radiation-recall-dermatitis-in-patients-treated-with-sorafenib
#5
Keyur Mehta, Andreas Kaubisch, Justin Tang, Aneesh Pirlamarla, Shalom Kalnicki
Introduction: Radiation recall dermatitis (RRD) is a phenomenon that occurs in previously irradiated areas shortly after administration of a chemotherapeutic agent. As the use of sorafenib expands, the incidence of radiation recall dermatitis induced by sorafenib will likely increase. Here, we report on a patient who developed RRD and describe his clinical characteristics along with a review of the literature. Case Presentation: Our patient was treated with palliative radiation therapy (RT) to a painful metastatic hepatocellular carcinoma lesion in the right forearm...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29650419/comparison-of-pathological-complete-response-rates-after-neoadjuvant-short-course-radiotherapy-or-chemoradiation-followed-by-delayed-surgery-in-locally-advanced-rectal-cancer
#6
Sieske Hoendervangers, Alice M Couwenberg, Martijn P W Intven, Wilhelmina M U van Grevenstein, Helena M Verkooijen
INTRODUCTION: Patients with locally advanced rectal cancer (LARC) who are unfit for chemoradiation (CRT), are often offered short-course radiotherapy followed by delayed surgery (SCRT-delay). This entails a lower radiation dose, no chemotherapy and a shorter treatment period. This may lower their chances for complete tumor response and, as such, organ-sparing approaches. The purpose of this study was to compare the pathological complete response (pCR) rates between neoadjuvant CRT and SCRT-delay in patients with LARC in a nationwide database from the Netherlands...
March 23, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29619931/approaches-to-radiotherapy-in-metastatic-spinal-cord-compression
#7
Morten Hiul Suppl
Metastatic spinal cord compression is caused by the progression of metastatic lesions within the vicinity of the spinal cord. The consequences are very severe with loss of neurological function and severe pain. The standard treatment is surgical intervention followed by radiotherapy or radiotherapy alone. However, the majority of patients are treated with radiotherapy only due to contraindications to surgery and technical inoperability. Stereotactic body radiotherapy is a technology to deliver higher radiation dose to the radiotherapy target with the use of spatial coordinates...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29600913/natural-history-of-cavernous-sinus-meningiomas
#8
Aymeric Amelot, Remy van Effenterre, Michel Kalamarides, Philippe Cornu, Anne-Laure Boch
OBJECTIVE Meningiomas confined to the cavernous sinus (MCSs) are benign tumors. Due to the high risk of severe complications, the intracavernous surgical procedure was abandoned in favor of radiotherapy. However, the choice of treatment remains complicated due to the fact that the natural history of this lesion has not yet been described. METHODS The authors studied the natural history of this lesion using a prospective series of 53 consecutive patients suffering from MCSs. The median follow-up duration was 10...
March 30, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29545982/cocaine-induced-type-a-aortic-dissection-extending-to-the-common-iliac-arteries
#9
Mohamed A Mohamed, Rohit Abraham, Tareq I Maraqa, Samir Elian
Aortic dissection is a rare and fatal complication of cocaine-induced hypertension. The injury mechanism is through shear stress that penetrates the intimal vessel layer, allowing blood flow to separate intimal and medial layers. Due to its scarcity and the paucity of related literature, our knowledge of this condition is limited. We present a rare case of a cocaine-induced aortic dissection, which extended continuously from the aortic root to the common iliacs, along with a literature review of similar cases...
January 12, 2018: Curēus
https://www.readbyqxmd.com/read/29485075/local-control-and-toxicity-of-external-beam-reirradiation-with-a-pulsed-low-dose-rate-technique
#10
Charles T Lee, Yanqun Dong, Tianyu Li, Samuel Freedman, Jordan Anaokar, Thomas J Galloway, Mark A Hallman, Stephanie E Weiss, Shelly B Hayes, Robert A Price, C M Charlie Ma, Joshua E Meyer
PURPOSE: To evaluate the efficacy and toxicity of external beam reirradiation using a pulsed low-dose-rate (PLDR) technique. METHODS AND MATERIALS: We evaluated patients treated with PLDR reirradiation from 2009 to 2016 at a single institution. Toxicity was graded using the Common Terminology Criteria for Adverse Events, version 4.0, and local control was assessed using the Response Evaluation Criteria In Solid Tumors, version 1.1. On univariate analysis (UVA), the χ2 and Fisher exact tests were used to assess the toxicity outcomes...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29429801/short-diffusion-time-diffusion-weighted-imaging-with-oscillating-gradient-preparation-as-an-early-magnetic-resonance-imaging-biomarker-for-radiation-therapy-response-monitoring-in-glioblastoma-a-preclinical-feasibility-study
#11
Andre Bongers, Eric Hau, Han Shen
PURPOSE: To investigate a novel alternative diffusion-weighted imaging (DWI) approach using oscillating gradients preparation (OGSE) to obtain much shorter effective diffusion times (Δeff ) for tumor response monitoring by apparent diffusion coefficient (ADC) mapping in a glioblastoma mouse model. METHODS AND MATERIALS: Twenty-four BALB/c nude mice inoculated with U87 glioblastoma cells were randomized into a control group and an irradiation group, which underwent a 15-day fractioned radiation therapy (RT) course with 2 Gy/d...
January 4, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29398455/short-course-accelerated-radiation-therapy-sharon-in-palliative-treatment-of-advanced-solid-cancer-in-older-patients-a-pooled-analysis
#12
Eleonora Farina, Jenny Capuccini, Gabriella Macchia, Luciana Caravatta, Nam P Nguyen, Silvia Cammelli, Giuseppe Zanirato Rambaldi, Savino Cilla, Tigeneh Wondemagegnhu, A F M Kamal Uddin, Mostafà Aziz Sumon, Domenico Genovesi, Milly Buwenge, Francesco Cellini, Vincenzo Valentini, Francesco Deodato, Alessio G Morganti
OBJECTIVES: To evaluate the efficacy and safety of a conformal Short Course Accelerated Radiation therapy (SHARON) for symptomatic palliation of locally advanced or metastatic cancers in older patients. MATERIALS AND METHODS: This is a pooled analysis on patients aged ≥80 years selected between subjects enrolled in 3 phase I-II studies on a short course palliative treatment of advanced or metastatic cancer. The primary endpoint was to evaluate the symptoms response rate produced by accelerated radiotherapy delivered in 4 total fractions in twice a day...
February 1, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29394683/-safety-of-laparoscopic-surgery-after-preoperative-short-course-radiotherapy-for-lower-rectal-cancer
#13
Hironori Minami, Tsuyoshi Konishi, Hironori Fukuoka, Shun Miyanari, Satoshi Murahashi, Ian Fukudome, Shinsuke Suzuki, Hajime Ushigome, Toshiya Nagasaki, Takashi Akiyoshi, Yoshiya Fujimoto, Satoshi Nagayama, Yosuke Fukunaga, Masashi Ueno
BACKGROUNDS: In the setting of routine use of preoperative chemoradiotherapy(CRT)for cStage II / III rectal cancer, shortcourse radiotherapy(short-RT)is selectively used for reducing local recurrence.The purpose of this study is to clarify the safety of laparoscopic surgery after preoperative short-RT for lower rectal cancer. METHODS: Twenty-eight patients who un- derwent short-RT followed by laparoscopic total mesorectal excision for cStage II / III lower rectal cancer were retrospectively analyzed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29390462/anaplastic-astrocytoma-with-aquaporin-4-positive-in-csf-a-case-report
#14
Yuanyuan Liu, Feng Gao, Hongjun Hao, Weiping Sun, Yining Huang
RATIONALE: An acute presentation with diffuse magnetic resonance imaging lesions can have a broad differential. Demyelination and malignancy are important considerations. Therefore, sometimes it is hard to differentiate glioma from some demyelinating diseases solely on imaging because of the similar clinical presentation and imaging features. Detection of highly specific serum autoantibody marker aquaporin-4 (AQP4)-IgG positivity has helped to define a category of neuromyelitis optica spectrum disorders (NMOSD), but the test of AQP4 antibody has not been reported in patients with glioma...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29330865/a-case-of-radiation-induced-osteosarcoma-of-the-skull-presenting-as-a-cutaneous-epidermotropic-tumor-with-a-short-latent-period
#15
Elham Rashidghamat, Jaime Eduardo Calonje
Radiation-induced sarcoma (RIS) is an unusual but well documented tumor. The frequency of RIS of the head and neck region has been reported as 0.143%. In the literature the median interval between irradiation and development of sarcoma is 11 years. Cases of RIS with a short latent period, that is, less than 4 years are rare. We report a case of a 34-year-old female who developed an osteosarcoma of the scalp, over a previous craniotomy scar, 3 years after excision of a frontal anaplastic oligodendroglioma which had been followed by a course of 6 weeks radiotherapy (58 Gy) and 6 cycles of temozolomide...
January 13, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29321610/physiological-effects-of-short-acute-uvb-treatments-in-chenopodium-quinoa-willd
#16
Thais Huarancca Reyes, Andrea Scartazza, Antonella Castagna, Eric G Cosio, Annamaria Ranieri, Lorenzo Guglielminetti
Increased ultraviolet B (UVB) radiation due to global change can affect plant growth and metabolism. Here, we evaluated the capacity of quinoa to resist under short acute UVB irradiation. Quinoa was daily exposed for 30 or 60 min to 1.69 W m-2 UVB. The results showed that 30 min exposure in 9 d-course did not cause severe alterations on photosynthetic pigments and flavonoids, but a significant increase of antioxidant capacity was observed. Otherwise, 60 min UVB in 5 d-course reduced almost all these parameters except for an increase in the de-epoxidation of xanthophyll cycle pigments and led to the death of the plants...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29299359/short-course-radiation-as-a-component-of-definitive-multidisciplinary-treatment-for-select-patients-with-metastatic-rectal-adenocarcinoma
#17
Emma B Holliday, Andrew Hunt, Y Nancy You, George J Chang, John M Skibber, Miguel A Rodriguez-Bigas, Brian K Bednarski, Cathy Eng, Eugene J Koay, Bruce D Minsky, Cullen Taniguchi, Sunil Krishnan, Joseph M Herman, Prajnan Das
Background: Select patients with rectal adenocarcinoma with metastatic disease at presentation can be cured with multimodality management. However, the optimal components and sequencing of therapy is unknown. The aim of this study is to evaluate outcomes for patients treated with chemotherapy, short course radiation therapy (SCRT) and surgical resection. Methods: Patients with newly diagnosed metastatic rectal adenocarcinoma who received SCRT from 2010-2016 were identified...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29280457/reirradiation-for-recurrent-pediatric-central-nervous-system-malignancies-a-multi-institutional-review
#18
Avani D Rao, Arif S Rashid, Qinyu Chen, Rosangela C Villar, Daria Kobyzeva, Kristina Nilsson, Karin Dieckmann, Alexey Nechesnyuk, Ralph Ermoian, Sara Alcorn, Shannon M MacDonald, Matthew M Ladra, Eric C Ford, Brian A Winey, Maria Luisa S Figueiredo, Michael J Chen, Stephanie A Terezakis
PURPOSE: Reirradiation has been proposed as an effective modality for recurrent central nervous system (CNS) malignancies in adults. We evaluated the toxicity and outcomes of CNS reirradiation in pediatric patients. METHODS AND MATERIALS: The data from pediatric patients <21 years of age at the initial diagnosis who developed a recurrent CNS malignancy that received repeat radiation therapy (RT) across 5 facilities in an international pediatric research consortium were retrospectively reviewed...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29248399/palliative-chemoradiotherapy-versus-radiotherapy-alone-for-dysphagia-in-advanced-oesophageal-cancer-a-multicentre-randomised-controlled-trial-trog-03-01
#19
Michael G Penniment, Paolo B De Ieso, Jennifer A Harvey, Sonya Stephens, Heather-Jane Au, Christopher J O'Callaghan, Andrew Kneebone, Samuel Y Ngan, Iain G Ward, Rajarshi Roy, Jennifer G Smith, Tirath Nijjar, James J Biagi, Liam A Mulroy, Rebecca Wong
BACKGROUND: A short course of radiotherapy is commonly prescribed for palliative relief of malignant dysphagia in patients with incurable oesophageal cancer. We compared chemoradiotherapy with radiotherapy alone for dysphagia relief in the palliative setting. METHODS: This multicentre randomised controlled trial included patients with advanced or metastatic oesophageal cancer who were randomly assigned (1:1) through a computer-generated adaptive biased coin design to either palliative chemoradiotherapy or radiotherapy alone for treatment of malignant dysphagia at 22 hospitals in Australia, Canada, New Zealand, and the UK...
February 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29222306/therapy-of-primary-cns-lymphoma-role-of-intensity-radiation-and-novel-agents
#20
REVIEW
Andrés José María Ferreri
Primary central nervous system (CNS) lymphomas represent a subgroup of malignancies with specific characteristics, an aggressive course, and unsatisfactory outcome in contrast with other lymphomas comparable for tumor burden and histological type. Despite the high sensitivity to conventional chemotherapy and radiotherapy, remissions are frequently short lasting. Treatment efficacy is limited by several factors, including the biology and microenvironment of this malignancy and the "protective" effect of the blood-brain barrier, which limits the access of most drugs to the CNS...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
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