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Short course radiation

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https://www.readbyqxmd.com/read/28622770/intensity-modulated-radiation-therapy-from-70gy-to-80gy-in-prostate-cancer-six-year-outcomes-and-predictors-of-late-toxicity
#1
Maria Jolnerovski, Julia Salleron, Véronique Beckendorf, Didier Peiffert, Anne-Sophie Baumann, Valérie Bernier, Sandrine Huger, Vincent Marchesi, Ciprian Chira
OBJECTIVE: To report grade ≥2 overall late rectal and urinary toxicities in patients (pts) with prostate cancer treated by intensity-modulated radiotherapy (IMRT) at 3 dose-levels. Identify predictors of radiation toxicity and report biochemical progression free survival (bPFS). METHODS: A total of 277 pts were treated with 70Gy (10.8%), 74Gy (63.9%) and 80 Gy (25.3%) using IMRT without pelvic irradiation were analyzed. Short or long-course androgen deprivation therapy (ADT) was allowed in 46...
June 16, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28606922/in-situ-vaccination-after-accelerated-hypofractionated-radiation-and-surgery-in-a-mesothelioma-mouse-model
#2
Luis De la Maza, Matthew Wu, Licun Wu, Hana Yun, Yidan Zhao, Mark Cattral, Andrea McCart, John Cho, Marc DePerrot
How best to sequence and integrate immunotherapy into standard of care is currently unknown. Clinical protocols with accelerated non-ablative hypofractionated radiation followed by surgery could provide an opportunity to implement immune checkpoint blockade.<br /><br />Experimental Design: We therefore assessed the impact of non-ablative hypofractionated radiation on the immune system in combination with surgery in a mouse mesothelioma model. Blunt surgery (R1 resection) was used to analyze the short term impact and radical surgery (R0 resection) was used to analyze the long-term impact of this radiation protocol before surgery...
June 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28602417/survival-outcomes-with-short-course-radiation-therapy-in-elderly-patients-with-glioblastoma-data-from-a-randomized-phase-3-trial
#3
Douglas Guedes de Castro, Juliana Matiello, Wilson Roa, Sunita Ghosh, Lucyna Kepka, Narendra Kumar, Valery Sinaika, Darejan Lomidze, Dalenda Hentati, Eduardo Rosenblatt, Elena Fidarova
PURPOSE: To perform a subset analysis of survival outcomes in elderly patients with glioblastoma from a randomized phase 3 trial comparing 2 short-course radiation therapy (RT) regimens in elderly and/or frail patients. METHODS AND MATERIALS: The original trial population included elderly and/or frail patients with a diagnosis of glioblastoma. Patients joined the phase 3, randomized, multicenter, prospective, noninferiority trial; were assigned to 1 of 2 groups in a 1:1 ratio, either short-course RT (25 Gy in 5 fractions, arm 1) or commonly used RT (40 Gy in 15 fractions, arm 2); and were stratified by age (<65 years and ≥65 years), Karnofsky Performance Status (KPS), and extent of surgery...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28602048/injected-corticosteroids-for-treating-plantar-heel-pain-in-adults
#4
REVIEW
Judy A David, Venkatesan Sankarapandian, Prince Rh Christopher, Ahana Chatterjee, Ashish S Macaden
BACKGROUND: Plantar heel pain, commonly resulting from plantar fasciitis, often results in significant morbidity. Treatment options include nonsteroidal anti-inflammatory drugs (NSAIDs), orthoses, physical therapy, physical agents (e.g. extracorporeal shock wave therapy (ESWT), laser) and invasive procedures including steroid injections. OBJECTIVES: To assess the effects (benefits and harms) of injected corticosteroids for treating plantar heel pain in adults. SEARCH METHODS: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, the Cochrane Central Register of Controlled Trials (the Cochrane Library), MEDLINE, Embase, CINAHL, clinical trials registries and conference proceedings...
June 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28587056/tolerance-of-the-brachial-plexus-to-high-dose-reirradiation
#5
Allen M Chen, Taeko Yoshizaki, Maria A Velez, Argin G Mikaeilian, Sophia Hsu, Minsong Cao
PURPOSE: To study the tolerance of the brachial plexus to high doses of radiation exceeding historically accepted limits by analyzing human subjects treated with reirradiation for recurrent tumors of the head and neck. METHODS AND MATERIALS: Data from 43 patients who were confirmed to have received overlapping dose to the brachial plexus after review of radiation treatment plans from the initial and reirradiation courses were used to model the tolerance of this normal tissue structure...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28577826/safety-considerations-in-stereotactic-body-radiation-therapy
#6
REVIEW
Eric Ford, Sonja Dieterich
Although many error pathways are common to both stereotactic body radiation therapy (SBRT) and conventional radiation therapy, SBRT presents a special set of challenges including short treatment courses and high-doses, an enhanced reliance on imaging, technical challenges associated with commissioning, special resource requirements for staff and training, and workflow differences. Emerging data also suggest that errors occur at a higher rate in SBRT treatments. Furthermore, when errors do occur they often have a greater effect on SBRT treatments...
July 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28470507/time-course-of-upper-limb-function-and-return-to-work-post-radiotherapy-in-young-adults-with-breast-cancer-a-pilot-randomized-control-trial-on-effects-of-targeted-exercise-program
#7
Marize Ibrahim, Thierry Muanza, Nadia Smirnow, Warren Sateren, Beatrice Fournier, Petr Kavan, Michael Palumbo, Richard Dalfen, Mary-Ann Dalzell
PURPOSE: Breast cancer (BC) diagnosis in young adults (YA) is rising, and both disease and treatments are aggressive in this population. Evidence supports the use of physical activity in reducing shoulder dysfunction, which is common among BC survivors. A pilot randomized clinical trial was performed to determine the effectiveness of a 12-week post-radiation exercise program in minimizing upper extremity dysfunction in YA with BC. METHODS: Participants were randomized to either an exercise arm or a control arm receiving standard care...
May 3, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28463150/external-beam-radiation-therapy-or-brachytherapy-with-or-without-short-course-neoadjuvant-androgen-deprivation-therapy-results-of-a-multicenter-prospective-study-of-quality-of-life
#8
Hiram A Gay, Martin G Sanda, Jingxia Liu, Ningying Wu, Daniel A Hamstra, John T Wei, Rodney L Dunn, Eric A Klein, Howard M Sandler, Christopher S Saigal, Mark S Litwin, Deborah A Kuban, Larry Hembroff, Meredith M Regan, Peter Chang, Jeff M Michalski
PURPOSE: The long-term effects of neoadjuvant androgen deprivation therapy (NADT) with radiation therapy on participant-reported health-related quality of life (HRQOL) have not been characterized in prospective multicenter studies. We evaluated HRQOL for 2 years among participants undergoing radiation therapy (RT) with or without NADT for newly diagnosed, early-stage prostate cancer. METHODS AND MATERIALS: We analyzed longitudinal cohort data from the Prostate Cancer Outcomes and Satisfaction with Treatment Quality Assessment Consortium to ascertain the HRQOL trajectory of men receiving NADT with external beam RT (EBRT) or brachytherapy...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28459606/hypofractionated-postmastectomy-radiation-therapy-is-safe-and-effective-first-results-from-a-prospective-phase-ii-trial
#9
Atif J Khan, Matthew M Poppe, Sharad Goyal, Kristine E Kokeny, Thomas Kearney, Laurie Kirstein, Deborah Toppmeyer, Dirk F Moore, Chunxia Chen, David K Gaffney, Bruce G Haffty
Purpose Conventionally fractionated postmastectomy radiation therapy (PMRT) takes approximately 5 to 6 weeks. Data supporting hypofractionated PMRT is limited. We prospectively evaluated a short course of hypofractionated PMRT, in which therapy was completed in 15 treatment days. Patients and Methods We delivered PMRT at a dose of 36.63 Gy in 11 fractions of 3.33 Gy over 11 days to the chest wall and the draining regional lymph nodes, followed by an optional mastectomy scar boost of four fractions of 3.33 Gy...
June 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28443515/indication-of-bevacizumab-for-cerebral-radiation-necrosis
#10
Hongqing Zhuang, Xiangkun Yuan, Zhiyong Yuan, Ping Wang
BACKGROUND: The effect of bevacizumab (BVZ) for cerebral radiation necrosis (CRN) was clear. However, the indications of BVZ had no reports. OBJECTIVE: The aim of the paper was to investigate the indications of BVZ for CRN. METHODS: Fourteen CRN patients (confirmed by imaging diagnosis)who underwent BVZ treatment between June 2011 and December 2014 were analyzed. BVZ was administered (5 mg/kg body weight) once every three to four weeks for at least three cycles...
April 25, 2017: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/28441375/primary-adrenal-angiosarcoma-a-rare-and-potentially-misdiagnosed-tumor
#11
Ariel Grajales-Cruz, Francis Baco-Viera, Ernesto Rive-Mora, Carlos Ramirez-Tanchez, David Tasso, Norma Arroyo-Portela, Elizabeth Calderon, Ilean Joan Padua-Octaviani, William Caceres-Perkins
A man aged 69 years presented with acute right flank pain secondary to a hemorrhagic large adrenal tumor. En bloc resection was performed to repair the inferior vena cava. Immunoperoxidase levels in the tumor were positive for factor VIII and CD31 and negative for S100, protein Melan-A, CD34, synaptophysin, chromogranin, desmin, muscle specific actin, ETFA (EMA), KRT20 (CK20), CDX2, TTF1, LNPEP (PLAP), inhibin, ?-fetoprotein, CD30, hepatocyte paraffin, and aberrant expression of cytokeratin 7 and pankeratin...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28439497/study-of-recombinant-human-interleukin-12-for-treatment-of-complications-after-radiotherapy-for-tumor-patients
#12
Na Guo, Wen-Qin Wang, Xiao-Jing Gong, Lei Gao, Li-Rong Yang, Wei-Na Yu, Hong-Yu Shen, Ling-Qin Wan, Xi-Feng Jia, Yi-Shan Wang, Yi Zhao
AIM: To evaluate the treatment effects of recombinant human interleukin-12 (rhIL-12) on radiotherapy complications, such as severe myelosuppression or pancytopenia, the decline or imbalance of immune function, etc. METHODS: The patients received high-dose and short-course precise radiotherapy, such as Cyber knife and image-guided radiotherapy (IGRT), which can cause myelosuppression or pancytopenia and immune function decline within a short time. One-hundred subjects were enrolled in the study, and 50 were randomized to a treatment group which used rhIL-12 and 50 were randomized to a control group which used symptomatic and supportive therapy after radiotherapy...
April 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28428205/measurable-supratentorial-white-matter-volume-changes-in-patients-with-diffuse-intrinsic-pontine-glioma-treated-with-an-anti-vascular-endothelial-growth-factor-agent-steroids-and-radiation
#13
P Svolos, W E Reddick, A Edwards, A Sykes, Y Li, J O Glass, Z Patay
BACKGROUND AND PURPOSE: Assessing the response to treatment in infiltrative brain tumors by using lesion volume-based response criteria is challenging. We hypothesized that in such tumors, volume measurements alone may not accurately capture changes in actual tumor burden during treatment. We longitudinally evaluated volume changes in both normal-appearing supratentorial white matter and the brain stem lesions in patients treated for diffuse intrinsic pontine glioma to determine to what extent adjuvant systemic therapies may skew the accuracy of tumor response assessments based on volumetric analysis...
June 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28408701/mucoepidermoid-parotid-gland-tumor-found-on-follow-up-radioiodine-scan-for-differentiated-papillary-thyroid-cancer
#14
REVIEW
Chinna Naik, Sandip Basu
This report presents a case of focal uptake in the right parotid gland found on a follow-up whole-body radioiodine scan 1 y after successful ablation of differentiated papillary thyroid carcinoma. After the parotid tumor had been excised, it was proven histopathologically to be a low-grade mucoepidermoid tumor. This case illustrates a (131)I focus that was false-positive for thyroid carcinoma. The short period between radioiodine treatment and development of this parotid tumor creates doubt about a causal relationship...
June 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28408528/cerenkov-radiation-induced-photoimmunotherapy-with-18-f-fdg
#15
Yuko Nakamura, Tadanobu Nagaya, Kazuhide Sato, Shuhei Okuyama, Fusa Ogata, Karen J Wong, Stephen Adler, Peter L Choyke, Hisataka Kobayashi
Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with toxicity induced by photo-absorbers after irradiation with NIR light. A limitation of NIR-PIT is the inability to deliver NIR light to a tumor located deep inside the body. Cerenkov radiation (CR) is ultraviolet and blue light which is produced by a charged particle travelling through a dielectric medium faster than the speed of light in that medium and is commonly produced during radioactive decay...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28328309/ibpro-a-novel-short-duration-teaching-course-in-advanced-physics-and-biology-underlying-cancer-radiotherapy
#16
Michael C Joiner, Monica W Tracey, Sara E Kacin, Jay W Burmeister
This article provides a summary and status report of the ongoing advanced education program IBPRO - Integrated course in Biology and Physics of Radiation Oncology. IBPRO is a five-year program funded by NCI. It addresses the recognized deficiency in the number of mentors available who have the required knowledge and skill to provide the teaching and training that is required for future radiation oncologists and researchers in radiation sciences. Each year, IBPRO brings together 50 attendees typically at assistant professor level and upwards, who are already qualified/certified radiation oncologists, medical physicists or biologists...
June 2017: Radiation Research
https://www.readbyqxmd.com/read/28302385/primary-cutaneous-interdigitating-dendritic-cell-sarcoma-is-a-morphologic-and-phenotypic-simulator-of-poorly-differentiated-metastatic-melanoma-a-report-of-2-cases-and-review-of-the-literature
#17
REVIEW
Cynthia M Magro, Luke C Olson, Gerard Nuovo, Garron J Solomon
Interdigitating dendritic cell sarcoma (IDS) is a rare form of hematologic malignancy associated with an aggressive clinical course. Only 4 prior cases have been described as originating in the skin. We encountered two male patients ages 47 and 61years of age who presented with solitary cutaneous neoplasms diagnosed as IDS. Histologic exam showed a coalescing nested and multinodular proliferation of large pleomorphic epithelioid cells. In one case an initial diagnosis of melanoma was rendered. A recurrence 8months later was then interpreted as a primary cutaneous IDS...
February 20, 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28299525/poems-syndrome-an-enigma
#18
REVIEW
Rahma Warsame, Uday Yanamandra, Prashant Kapoor
POEMS syndrome is a paraneoplastic disorder secondary to an underlying plasma cell dyscrasia. By definition, all patients with POEMS syndrome must display polyneuropathy and monoclonal plasma cell disorder. In addition, at least one major criterion (Castleman's disease, sclerotic bone lesions, or vascular endothelial growth factor elevation) and one minor criterion (organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema, thrombocytosis, or polycythemia) are required for diagnosis...
April 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28296618/short-course-radiation-plus-temozolomide-in-elderly-patients-with-glioblastoma
#19
RANDOMIZED CONTROLLED TRIAL
James R Perry, Normand Laperriere, Christopher J O'Callaghan, Alba A Brandes, Johan Menten, Claire Phillips, Michael Fay, Ryo Nishikawa, J Gregory Cairncross, Wilson Roa, David Osoba, John P Rossiter, Arjun Sahgal, Hal Hirte, Florence Laigle-Donadey, Enrico Franceschi, Olivier Chinot, Vassilis Golfinopoulos, Laura Fariselli, Antje Wick, Loic Feuvret, Michael Back, Michael Tills, Chad Winch, Brigitta G Baumert, Wolfgang Wick, Keyue Ding, Warren P Mason
BACKGROUND: Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy is added to standard radiotherapy (60 Gy over a period of 6 weeks). In elderly patients, more convenient shorter courses of radiotherapy are commonly used, but the benefit of adding temozolomide to a shorter course of radiotherapy is unknown. METHODS: We conducted a trial involving patients 65 years of age or older with newly diagnosed glioblastoma...
March 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28291546/acute-toxicity-and-surgical-complications-after-preoperative-chemo-radiation-therapy-for-rectal-cancer-in-patients-with-inflammatory-bowel-disease
#20
Steven L Bosch, Stefan J van Rooijen, Guus M J Bökkerink, Hidde J W Braam, Lauranne A A P Derikx, Philip Poortmans, Corrie A M Marijnen, Iris D Nagtegaal, Johannes H W de Wilt
PURPOSE: Preoperative therapy reduces local recurrences and may facilitate surgery in rectal cancer patients. However, in patients with inflammatory bowel disease (IBD) this treatment is often withheld due to the perceived risk of excessive side-effects, even though evidence is limited. The purpose of this study is to investigate the effects of preoperative therapy on acute toxicity and post-operative complications in IBD patients with rectal cancer. METHODS: The Dutch pathology registry (PALGA) was searched for patients with IBD and rectal cancer treated between January 1991 and May 2010...
April 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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