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Short course radiation

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https://www.readbyqxmd.com/read/28086825/toxicity-and-quality-of-life-report-of-a-phase-ii-study-of-stereotactic-body-radiotherapy-sbrt-for-low-and-intermediate-risk-prostate-cancer
#1
Matthew J Boyer, Michael A Papagikos, Rex Kiteley, Zeljko Vujaskovic, Jackie Wu, W Robert Lee
BACKGROUND: Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radiotherapy with real-time motion management and daily plan re-optimization for low to intermediate risk prostate cancer was undertaken to evaluate this hypothesis. This report details the toxicity and quality of life following treatment. METHODS: From 2009 to 2013, 60 patients with T1-T2c prostate cancer with a Gleason score of 6 and PSA ≤ 15 or Gleason score of 7 and PSA ≤ 10 were enrolled...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28060889/sequential-pet-ct-with-18f-fdg-predicts-pathological-tumor-response-to-preoperative-short-course-radiotherapy-with-delayed-surgery-in-patients-with-locally-advanced-rectal-cancer-using-logistic-regression-analysis
#2
Biagio Pecori, Secondo Lastoria, Corradina Caracò, Marco Celentani, Fabiana Tatangelo, Antonio Avallone, Daniela Rega, Giampaolo De Palma, Maria Mormile, Alfredo Budillon, Paolo Muto, Francesco Bianco, Luigi Aloj, Antonella Petrillo, Paolo Delrio
: Previous studies indicate that FDG PET/CT may predict pathological response in patients undergoing neoadjuvant chemo-radiotherapy for locally advanced rectal cancer (LARC). Aim of the current study is evaluate if pathological response can be similarly predicted in LARC patients after short course radiation therapy alone. METHODS: Thirty-three patients with cT2-3, N0-2, M0 rectal adenocarcinoma treated with hypo fractionated short course neoadjuvant RT (5x5 Gy) with delayed surgery (SCRTDS) were prospectively studied...
2017: PloS One
https://www.readbyqxmd.com/read/28058956/neuromuscular-blockade-and-inspiratory-breath-hold-during-stereotactic-body-radiation-therapy-for-treatment-of-heart-base-tumors-in-four-dogs
#3
Krista L Kelsey, Lyndsay N Kubicek, Nicholas J Bacon, Terry Torres, Sheilah A Robertson
CASE DESCRIPTION 4 dogs were examined because of pleural effusion and ventricular tachycardia, coughing and supraventricular tachycardia, appendicular osteosarcoma, and syncopal episodes. CLINICAL FINDINGS In all 4 dogs, a heart base tumor was identified by means of thoracic CT. TREATMENT AND OUTCOME In all 4 dogs, the heart base tumors were treated by means of stereotactic body radiation therapy. Dogs were anesthetized, and neuromuscular blockade was achieved with atracurium or vecuronium. A circle rebreathing system with 15 m (50 feet) of anesthetic tubing coursing through the vault wall was used to connect the patient to the anesthesia machine, which was located in the control room...
January 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28027555/vestibular-and-acustic-dysfunctions-in-clean-up-workers-of-chornobyl-accident-30-years-of-follow-up
#4
D I Zabolotnyi, N S Mishchanchuk
OBJECTIVE: The objective of the work was to study the clinical and electrophysiological disorders in vestibular and acustic dysfunctions in clean up workers of Chornobyl accident depending on the dose and duration of action of ion izing radiation, the peculiarities of determined effects for 30 years after the accident. MATERIALS AND METHODS: The standard clinical and electrophysiological examinations of vestibular and acoustic ana lyzers functions were conducted in 7812 males' clean up workers including 325 persons selected for prolonged stud ies in 1986 2015...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/28027156/education-vs-training-does-it-matter
#5
Kathryn A Higley
The National Council on Radiation Protection and Measurements' (NCRP) "Where are the Radiation Professionals?" initiative brought renewed attention to the declining numbers of individuals in radiation protection fields. This paper is an expanded version of the oral presentation by the author at the 2016 NCRP Annual Meeting. Health physics (HP) as a discipline and vocation is at a critical juncture. Perhaps less well recognized is the extreme peril facing academic HP programs. Higher education today is vastly different from what it was even 20 y ago...
February 2017: Health Physics
https://www.readbyqxmd.com/read/27984651/neoadjuvant-long-course-chemoradiation-remains-strongly-favored-over-short-course-radiotherapy-by-radiation-oncologists-in-the-united-states
#6
Yvonne M Mowery, Joseph K Salama, S Yousuf Zafar, Harvey G Moore, Christopher G Willett, Brian G Czito, M Benjamin Hopkins, Manisha Palta
BACKGROUND: Short-course radiotherapy (SC-RT) and long-course chemoradiotherapy (LC-CRT) are accepted neoadjuvant treatments of rectal cancer. In the current study, the authors surveyed US radiation oncologists to assess practice patterns and attitudes regarding SC-RT and LC-CRT for patients with rectal cancer. METHODS: The authors distributed a survey to 1701 radiation oncologists regarding treatment of neoadjuvant rectal cancer. Respondents were asked questions regarding the number of patients with rectal cancer treated, preference for SC-RT versus LC-CRT, and factors influencing regimen choice...
December 16, 2016: Cancer
https://www.readbyqxmd.com/read/27905053/seom-clinical-guideline-of-localized-rectal-cancer-2016
#7
E González-Flores, F Losa, C Pericay, E Polo, S Roselló, M J Safont, R Vera, J Aparicio, M T Cano, C Fernández-Martos
Localized rectal adenocarcinoma is a heterogeneous disease and current treatment recommendations are based on a preoperative multidisciplinary evaluation. High-resolution magnetic resonance imaging and endoscopic ultrasound are complementary to do a locoregional accurate staging. Surgery remains the mainstay of treatment and preoperative therapies with chemoradiation (CRT) or short-course radiation (SCRT) must be considered in more locally advanced cases. Novel strategies with induction chemotherapy alone or preceding or after CRT (SCRT) and surgery are in development...
December 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27901473/influence-of-solar-and-geomagnetic-activity-in-gymnodinium-catenatum-dinophyceae-cultures
#8
Paulo Vale
Laboratory cultures of the paralytic shellfish poisoning producing microalga Gymnodinium catenatum were subjected to a hypo-osmotic shock and changes in cell concentration were observed in two separate experiments of 8 and 24 hours duration, respectively. The increase in geomagnetic activity (GMA), radio and X-ray fluxes and solar X-ray flares were negatively correlated with cell numbers. Cell losses were observed in the short experiment, but not in the longest one. GMA action was related to the course of the experimental period, while electromagnetic radiation (EMR) was only significantly related when the previous hours before the experiments were considered...
November 30, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27886277/a-retrospective-analysis-on-two-week-short-course-pre-operative-radiotherapy-in-elderly-patients-with-resectable-locally-advanced-rectal-cancer
#9
Chen Shi, Hao Zhou, Xiaofan Li, Yong Cai
To validate that a two-week short-course pre-operative radiotherapy regimen is feasible, safe, and effective for the management of elderly patients with locally advanced rectal cancer (LARC), we retrospectively analyzed 99 radiotherapy-naive patients ≥70 years of age with LARC. Patients received pelvic radiation therapy (3D-CRT 30Gy/10f/2w) followed by TME surgery; some patients received adjuvant chemotherapy. The primary endpoint was OS, while the secondary endpoints were DFS, safety and response rate. The median follow-up time was 5...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27801411/-the-influence-of-short-wavelength-ultraviolet-radiation-on-the-healing-of-thermal-wounds-an-experimental-study
#10
M M Rasulov, I G Motorina, G G Yushkov, V V Igumen'shcheva, N A Malyshkina, O G Solominskaya, V V Benemansky, T M Filippova
: The topicality of the problem stated in the title of the this article is attributable to the lack of up-to-date information on the treatment of thermal skin wounds with the use of short wavelength ultraviolet radiation (UVR). The objective of the present study was to evaluate the effectiveness of the courses of short wavelength ultraviolet radiation under experimental conditions using a model of standardized thermal skin wounds in rabbits starting from the proliferative phase of the healing...
2016: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/27795811/current-debate-in-the-oncologic-management-of-rectal-cancer
#11
REVIEW
Trish Millard, Paul R Kunk, Erika Ramsdale, Osama E Rahma
Despite the considerable amount of research in the field, the management of locally advanced rectal cancer remains a subject to debate. To date, effective treatment centers on surgical resection with the standard approach of total mesorectal resection. Radiation therapy and chemotherapy have been incorporated in order to decrease local and systemic recurrence. While it is accepted that a multimodality treatment regimen is indicated, there remains significant debate for how best to accomplish this in regards to order, dosing, and choice of agents...
October 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27788949/is-there-a-role-for-pelvic-irradiation-in-localized-prostate-adenocarcinoma-update-of-the-long-term-survival-results-of-the-getug-01-randomized-study
#12
Pascal Pommier, Sylvie Chabaud, Jean-Leon Lagrange, Pierre Richaud, Elisabeth Le Prise, Jean-Philippe Wagner, David Azria, Veronique Beckendorf, Jean-Philippe Suchaud, Valerie Bernier, David Perol, Christian Carrie
PURPOSE: To report the long-term results of the French Genitourinary Study Group (GETUG)-01 study in terms of event-free survival (EFS) and overall survival (OS) and assess the potential interaction between hormonotherapy and pelvic nodes irradiation. PATIENTS AND METHODS: Between December 1998 and June 2004, 446 patients with T1b-T3, N0pNx, M0 prostate carcinoma were randomly assigned to either pelvic nodes and prostate or prostate-only radiation therapy. Patients were stratified into 2 groups: "low risk" (T1-T2 and Gleason score 6 and prostate-specific antigen <3× the upper normal limit of the laboratory) (92 patients) versus "high risk" (T3 or Gleason score >6 or prostate-specific antigen >3× the upper normal limit of the laboratory)...
November 15, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27773728/clinical-presentation-management-follow-up-and-outcomes-of-isolated-celiac-and-superior-mesenteric-artery-dissections
#13
Sara L Zettervall, Eleonora G Karthaus, Peter A Soden, Dominique B Buck, Klaas H J Ultee, Marc L Schermerhorn, Mark C Wyers
OBJECTIVE: Isolated visceral artery dissections are rare entities with no current consensus guidelines for treatment and follow-up. This study aims to evaluate the presentation, management, outcomes, and follow-up practices for patients with isolated visceral artery dissections and to compare those with and without symptoms. METHODS: In this retrospective analysis, we identified all patients with isolated celiac artery and/or isolated superior mesenteric artery dissections at a single institution between September 2006 and December 2014...
January 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27729942/vero%C3%A2-radiotherapy-for-low-burden-cancer-789-patients-with-957-lesions
#14
R Orecchia, A Surgo, M Muto, A Ferrari, G Piperno, M A Gerardi, S Comi, C Garibaldi, D Ciardo, A Bazani, F Golino, F Pansini, C Fodor, P Romanelli, D Maestri, V Scroffi, S Mazza, B A Jereczek-Fossa
PURPOSE: The aim of this retrospective study is to evaluate patient profile, feasibility, and acute toxicity of RadioTherapy (RT) delivered by VERO® in the first 20 months of clinical activity. METHODS: Inclusion criteria: 1) adult patients; 2) limited volume cancer (M0 or oligometastatic); 3) small extracranial lesions; 4) treatment between April 2012 and December 2013 and 5) written informed consent. Two techniques were employed: intensity modulated radiotherapy (IMRT) and stereotactic body radiotherapy (SBRT)...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27720702/preoperative-short-course-radiation-therapy-for-rectal-cancer-provides-excellent-disease-control-and-toxicity-results-from-a-single-us-institution
#15
Amit Roy, Pawinee Mahasittiwat, Ashley A Weiner, Steven R Hunt, Matthew G Mutch, Elisa H Birnbaum, Ira J Kodner, Thomas E Read, James W Fleshman, Jeffrey R Olsen, Robert J Myerson, Parag J Parikh
PURPOSE: Preoperative short-course radiation therapy (SCRT) has rarely been used for rectal cancer in the United States, although 2 randomized phase 3 trials demonstrate equivalence to conventional chemoradiation (CRT), and recent updates to national guidelines include this regimen as a treatment option. We sought to evaluate the efficacy and safety of preoperative SCRT followed by immediate surgery within 1 week to treat rectal cancer in the US setting. METHODS AND MATERIALS: All patients treated with preoperative SCRT (4 Gy × 5 fractions for total 20 Gy) followed by planned surgery within 1 week at our institution were retrospectively evaluated...
January 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27682899/combined-hydration-and-antibiotics-with-lisinopril-to-mitigate-acute-and-delayed-high-dose-radiation-injuries-to-multiple-organs
#16
Brian L Fish, Feng Gao, Jayashree Narayanan, Carmen Bergom, Elizabeth R Jacobs, Eric P Cohen, John E Moulder, Christie M Orschell, Meetha Medhora
The NIAID Radiation and Nuclear Countermeasures Program is developing medical agents to mitigate the acute and delayed effects of radiation that may occur from a radionuclear attack or accident. To date, most such medical countermeasures have been developed for single organ injuries. Angiotensin converting enzyme (ACE) inhibitors have been used to mitigate radiation-induced lung, skin, brain, and renal injuries in rats. ACE inhibitors have also been reported to decrease normal tissue complication in radiation oncology patients...
November 2016: Health Physics
https://www.readbyqxmd.com/read/27675799/short-course-hypofractionated-whole-breast-radiation-therapy-after-conservative-surgery-a-single-institution-prospective-study
#17
P Pinnaro, C Giordano, A Farneti, R Rambone, G Sanguineti
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675787/radiation-oncologists-practice-patterns-and-attitudes-regarding-neoadjuvant-short-course-radiation-therapy-for-rectal-cancer-in-the-united-states
#18
Y M Mowery, J K Salama, S Y Zafar, H G Moore, C G Willett, B Czito, M B Hopkins, M Palta
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675674/short-course-radiation-therapy-for-merkel-cell-carcinoma-relative-effectiveness-in-a-radiosensitive-tumor
#19
N Cimbak, C A Barker
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675556/the-use-of-a-biopsy-based-genomic-classifier-to-predict-the-risk-of-distant-metastasis-after-definitive-radiation-and-short-course-androgen-deprivation-therapy-for-intermediate-and-high-risk-prostate-cancer
#20
P L Nguyen, N E Martin, B J Palmer-Aronsten, V Choeurng, T Kolisnik, C J Beard, M D Nezolosky, Y W Chen, H Shin, E Davicioni, F Feng
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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