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https://www.readbyqxmd.com/read/28091585/microrna-19b-is-a-potential-biomarker-of-increased-myocardial-collagen-cross-linking-in-patients-with-aortic-stenosis-and-heart-failure
#1
Javier Beaumont, Begoña López, Susana Ravassa, Nerea Hermida, Gorka San José, Idoia Gallego, Félix Valencia, Juan José Gómez-Doblas, Eduardo de Teresa, Javier Díez, Arantxa González
This study analyzed the potential associations of 7 myocardial fibrosis-related microRNAs with the quality of the collagen network (e.g., the degree of collagen fibril cross-linking or CCL) and the enzyme lysyl oxidase (LOX) responsible for CCL in 28 patients with severe aortic stenosis (AS) of whom 46% had a diagnosis of chronic heart failure (HF). MicroRNA expression was analyzed in myocardial and blood samples. From the studied microRNAs only miR-19b presented a direct correlation (p < 0.05) between serum and myocardium...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28089872/identification-of-airway-mucosal-type-2-inflammation-by-clinical-biomarkers-in-asthma
#2
Philip E Silkoff, Michel Laviolette, Dave Singh, J Mark FitzGerald, Steven Kelsen, Vibeke Backer, Celeste M Porsbjerg, Pierre-Olivier Girodet, Patrick Berger, Joel N Kline, Geoffrey Chupp, Vedrana S Susulic, Elliot S Barnathan, Frédéric Baribaud, Matthew J Loza
BACKGROUND AND OBJECTIVE: The Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study profiled mild, moderate and severe asthma, and non-atopic healthy controls. We explored this dataset to define Type-2 inflammation based on airway-mucosal IL-13-driven gene expression and how this related to clinically-accessible biomarkers. METHODS: IL-13-driven gene expression was evaluated in several human cell lines. We then defined Type-2 status in 25 healthy subjects, 28 mild, 29 moderate, and 26 severe asthmatics, based on airway-mucosal expression of 1) CC-motif chemokine ligand (CCL)-26, (the most differentially expressed gene), 2) periostin, or 3) a multi-gene IL-13 in-vitro signature (IVS)...
January 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28081470/inhibition-viral-rnp-and-anti-inflammatory-activity-of-coumarins-against-influenza-virus
#3
YuTao Wang, Wen Yan, QiaoLian Chen, WanYi Huang, Zifeng Yang, Xiong Li, XinHua Wang
Influenza viruses pose a severe threat to human health and a significant increase in antiviral drug-resistant among influenza viruses worldwide has been observed. Therefore, there is an urgent need to develop the new antiviral drugs, specifically from the natural products. In this study, the anti-viral and anti-inflammatory activities of coumarins against influenza A virus in vitro were investigated. One of the derivatives eleutheroside B1 showed a wide spectrum of anti- human influenza virus effect with the IC50 value of 64-125μg/ml in vitro, but it showed no effects against avian influenza virus...
January 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28073079/trail-facilitates-cytokine-expression-and-macrophage-migration-during-hypoxia-reoxygenation-via-er-stress-dependent-nf-%C3%AE%C2%BAb-pathway
#4
Yinan Jiang, Xiaoyan Chen, Mengya Fan, Hui Li, Weina Zhu, Xi Chen, Chenghua Cao, Rui Xu, Yaohui Wang, Yuanfang Ma
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is known as a key molecule to induce cancer cell apoptosis, has also been found to participate in the process of ischemia/reperfusion (I/R) injury. Infiltrated macrophages play dual roles in inflammatory injury and healing following I/R. Whether TRAIL has any effect on macrophages during this process remains elusive. Here we showed that I/R triggered the expressions of TRAIL, DR5 and cytokines (IL-1β, TNFα, CCL-2 and ICAM-1), in addition to macrophage infiltration, which could be abolished by TRAIL neutralizing antibody...
January 7, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28060303/an-in-vitro-model-of-the-blood-brain-barrier-using-impedance-spectroscopy-a-focus-on-t-cell-endothelial-cell-interaction
#5
Ivan Kuzmanov, Alexander M Herrmann, Hans-Joachim Galla, Sven G Meuth, Heinz Wiendl, Luisa Klotz
Breakdown of the blood-brain barrier (BBB) is a critical step in the development of autoimmune diseases such as multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). This process is characterized by the transmigration of activated T cells across brain endothelial cells (ECs), the main constituents of the BBB. However, the consequences on brain EC function upon interaction with such T cells are largely unknown. Here we describe an assay that allows for the evaluation of primary mouse brain microvascular EC (MBMEC) function and barrier integrity during the interaction with T cells over time...
December 8, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28055982/preparation-of-multi-location-reduction-sensitive-core-crosslinked-folate-peg-coated-micelles-for-rapid-release-of-doxorubicin-and-tariquidar-to-overcome-drug-resistance
#6
Xiaoqing Yi, Dan Zhao, Quan Zhang, Jiaqi Xu, Gongdao Yuan, Renxi Zhuo, Feng Li
Herein we prepared folate-targeting core crosslinked polymeric micelles (CCL/FA) containing multiple disulfide bonds located on the interface and core of the micelles to co-deliver doxorubicin (DOX) and P-glycoprotein (P-gp) inhibitor tariquidar (TQR) for reversing drug resistance. The stability and redox-responsive behaviors of CCL/FA micelles were evaluated from the changes of morphology, molecular weight and the hydrodynamic size. On the one hand, the micelles possessed good stability that led to the suppression of drug release from the CCL micelles in physiological environment...
January 5, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28048767/su-f-i-77-radiation-dose-in-cardiac-catheterization-procedures-impact-of-a-systematic-reduction-in-pulsed-fluoroscopy-frame-rate
#7
C Schultz, S Dixon
PURPOSE: To evaluate whether one small systematic reduction in fluoroscopy frame rate has a significant effect on the total air kerma and/or dose area product for diagnostic and interventional cardiac catheterization procedures. METHODS: The default fluoroscopy frame rate (FFR) was lowered from 15 to 10 fps in 5 Siemens™ Axiom Artis cardiac catheterization labs (CCL) on July 1, 2013. A total of 7212 consecutive diagnostic and interventional CCL procedures were divided into two study groups: 3602 procedures from 10/1/12 -6/30/13 with FFR of 15 fps; and 3610 procedures 7/1/13 - 3/31/14 at 10 fps...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28024553/sustained-performance-of-a-physicianless-system-of-automated-prehospital-stemi-diagnosis-and-catheterization-laboratory-activation
#8
Brian J Potter, Alexis Matteau, Samer Mansour, Charbel Naim, Mounir Riahi, Richard Essiambre, Martine Montigny, Isabelle Sareault, François Gobeil
BACKGROUND: Treatment times for primary percutaneous coronary intervention frequently exceed the recommended maximum delay. Automated "physicianless" systems of prehospital cardiac catheterization laboratory (CCL) activation show promise, but have been met with resistance over concerns regarding the potential for false positive and inappropriate activations (IAs). METHODS: From 2010 to 2015, first responders performed electrocardiograms (ECGs) in the field for all patients with a complaint of chest pain or dyspnea...
January 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28018908/partial-cranial-cruciate-ligament-tears-treated-with-stem-cell-and-platelet-rich-plasma-combination-therapy-in-36-dogs-a-retrospective-study
#9
Sherman O Canapp, Christopher S Leasure, Catherine Cox, Victor Ibrahim, Brittany J Carr
OBJECTIVE: To evaluate outcomes in 36 dogs with a partial cranial cruciate ligament (CCL) tear treated with autologous bone marrow aspirate concentrate (BMAC) or adipose-derived progenitor cells (ADPC) with platelet-rich plasma (PRP) combination. MATERIALS AND METHODS: Medical records of client-owned dogs diagnosed with an early partial (≤50%) tear of the craniomedial band of the CCL that was treated with BMAC-PRP or ADPC-PRP were reviewed from 2010 to 2015. Signalment, medical history, physical and orthopedic examination, objective temporospatial gait analyses, radiographs, day 0 and day 90 diagnostic arthroscopy findings, treatment, and outcome were among the data collected...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28011355/elimination-of-representative-contaminant-candidate-list-viruses-coxsackievirus-echovirus-hepatitis-a-virus-and-norovirus-from-water-by-coagulation-processes
#10
N Shirasaki, T Matsushita, Y Matsui, K Murai, A Aochi
We examined the removal of representative contaminant candidate list (CCL) viruses (coxsackievirus [CV] B5, echovirus type [EV] 11, and hepatitis A virus [HAV] IB), recombinant norovirus virus-like particles (rNV-VLPs), and murine norovirus (MNV) type 1 by coagulation. Water samples were subjected to coagulation with polyaluminum chloride (PACl, basicity 1.5) followed by either settling or settling and filtration. Together with our previously published results, the removal ratio order, as evaluated by a plaque-forming-unit method or an enzyme-linked immunosorbent assay after settling, was HAV>EV=rNV-VLPs≥CV=poliovirus type 1=MNV>adenovirus type 40 (range, 0...
December 8, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27999369/protective-effects-of-hydrolyzed-nucleoproteins-from-salmon-milt-against-ethanol-induced-liver-injury-in-rats
#11
Akiko Kojima-Yuasa, Mayu Goto, Eri Yoshikawa, Yuri Morita, Hirotaka Sekiguchi, Keita Sutoh, Koji Usumi, Isao Matsui-Yuasa
Dietary nucleotides play a role in maintaining the immune responses of both animals and humans. Oral administration of nucleic acids from salmon milt have physiological functions in the cellular metabolism, proliferation, differentiation, and apoptosis of human small intestinal epithelial cells. In this study, we examined the effects of DNA-rich nucleic acids prepared from salmon milt (DNSM) on the development of liver fibrosis in an in vivo ethanol-carbon tetrachloride cirrhosis model. Plasma aspartate transaminase and alanine transaminase were significantly less active in the DNSM-treated group than in the ethanol plus carbon tetrachloride (CCl₄)-treated group...
December 19, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27994901/avulsion-fracture-of-the-coracoid-process-at-the-coracoclavicular-ligament-insertion-a-report-of-three-cases
#12
Takeshi Morioka, Kiyohisa Ogawa, Masaaki Takahashi
Avulsion fracture at the site of attachment of the coracoid process of the coracoclavicular ligament (CCL) is extremely rare. We presented three adult cases of this unusual avulsion fracture associated with other injuries. Case  1 was a 25-year-old right-handed male with a left distal clavicular fracture with an avulsion fracture of the coracoid attachment of the CCL; this case was treated surgically and achieved an excellent outcome. Case  2 was a 39-year-old right-handed male with dislocation of the left acromioclavicular joint with two avulsion fractures: one at the posteromedial surface of the coracoid process at the attachment of the conoid ligament and one at the inferior surface of the clavicle at the attachment site of the trapezoid ligament; this case was treated conservatively, and unfavorable symptoms such as dull pain at rest and sharp pain during some daily activities remained...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27960185/phlda1-promotes-lung-contusion-by-regulating-the-toll-like-receptor-2-signaling-pathway
#13
Shaohua Wang, Hua Zhang, An Wang, Dayu Huang, Jie Fan, Lu Lu, Xiaofeng Chen
BACKGROUND/AIMS: Lung contusion is a potentially lethal injury. Pleckstrin homology-like domain family A, member-1 (PHLDA1) is known to play crucial roles in cell proliferation and apoptosis. In this study, we investigated the biological role of PHLDA1 in lung contusion. METHODS: The expression levels of PHLDA1 and TLR2 were detected by real time PCR and western. The cytokines were determined by ELISA. The inflammatory factors were detected by flow cytometry. The lung injury was determined by HE staining...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27959814/a-gpu-accelerated-approach-for-feature-tracking-in-time-varying-imagery-datasets
#14
Chao Peng, Saindip Sahani, John Rushing
We propose a novel parallel Connected Component Labeling (CCL) algorithm along with efficient out-of-core data management to detect and track feature regions of large time-varying imagery datasets. Our approach contributes to big data field with parallel algorithms tailored for GPU architectures. We remove the data dependency between frames and achieve pixel-level parallelism. Due to the large size, the entire dataset cannot fit into cached memory. Frames have to be streamed through the memory hierarchy (disk to CPU main memory and then to GPU memory), partitioned and processed as batches, where each batch is small enough to fit into the GPU...
December 9, 2016: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27941926/dihydroartemisinin-inhibits-catabolism-in-rat-chondrocytes-by-activating-autophagy-via-inhibition-of-the-nf-%C3%AE%C2%BAb-pathway
#15
Li-Bo Jiang, De-Hua Meng, Soo-Min Lee, Shu-Hao Liu, Qin-Tong Xu, Yang Wang, Jian Zhang
Osteoarthritis is a disease with inflammatory and catabolic imbalance in cartilage. Dihydroartemisinin (DHA), a natural and safe anti-malarial agent, has been reported to inhibit inflammation, but its effects on chondrocytes have yet to be elucidated. We investigated the effects of DHA on catabolism in chondrocytes. Viability of SD rats chondrocytes was analyzed. Autophagy levels were determined via expression of autophagic markers LC3 and ATG5, GFP-LC3 analysis, acridine orange staining, and electron microscopy...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27941627/hepatoprotective-effect-of-cuscuta-campestris-yunck-whole-plant-on-carbon-tetrachloride-induced-chronic-liver-injury-in-mice
#16
Wen-Huang Peng, Yi-Wen Chen, Meng-Shiou Lee, Wen-Te Chang, Jen-Chieh Tsai, Ying-Chih Lin, Ming-Kuem Lin
Cuscuta seeds and whole plant have been used to nourish the liver and kidney. This study was aimed to investigate the hepatoprotective activity of the ethanol extract of Cuscuta campestris Yunck. whole plant (CCEtOH). The hepatoprotective effect of CCEtOH (20, 100 and 500 mg/kg) was evaluated on carbon tetrachloride (CCl₄)-induced chronic liver injury. Serum alanine aminotransferase, aspartate aminotransferase, triglyceride and cholesterol were measured and the fibrosis was histologically examined. CCEtOH exhibited a significant inhibition of the increase of serum alanine aminotransferase, aspartate aminotransferase, triglyceride and cholesterol...
December 7, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27939226/effectiveness-of-a-prehospital-wireless-12-lead-electrocardiogram-and-cardiac-catheterization-laboratory-activation-for-st-elevation-myocardial-infarction
#17
Alain Tanguay, Eric Brassard, Johann Lebon, François Bégin, Denise Hébert, Jean-Michel Paradis
The aim of the study was to determine the prevalence of false-positive and inappropriate cardiac catheterization laboratory (CCL) activation in patients suspected with ST-elevation myocardial infarction (STEMI) diverted to a percutaneous coronary intervention (PCI) facility after paramedics wireless 12-lead electrocardiogram transmission to an emergency physician at an online medical control center. This retrospective study collected data from medical records of patients with suspected STEMI from 2006 to 2014...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27936868/decontamination-of-coalmine-effluent-generated-at-the-rajrappa-coalmine-using-phytoremediation-technology
#18
Kalpana C Lakra, B Lal, T K Banerjee
Toxicity of the effluent generated at the Rajrappa coalmine complex under the Central Coalfields Limited, (CCL, a subsidiary of Coal India Limited) in Jharkhand, India was investigated. The concentrations (mg L(-1)) of all the toxic metals (Fe, Mn, Ni, Zn, Cu, Pb, Cr and Cd) in the coalmine effluent were above the safe limit suggested by the Environmental Protection Agency (EPA, 2003). Amongst these, Fe showed the highest concentration (18.21±3.865), while Cr had the lowest effluent concentration (0.15±0...
December 12, 2016: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/27935962/map3k19-is-overexpressed-in-copd-and-is-a-central-mediator-of-cigarette-smoke-induced-pulmonary-inflammation-and-lower-airway-destruction
#19
Stefen A Boehme, Karin Franz-Bacon, John Ludka, Danielle N DiTirro, Tai Wei Ly, Kevin B Bacon
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and lung inflammation resulting in a progressive decline in lung function whose principle cause is cigarette smoke. MAP3K19 is a novel kinase expressed predominantly by alveolar and interstitial macrophages and bronchial epithelial cells in the lung. We found that MAP3K19 mRNA was overexpressed in a limited sampling of lung tissue from COPD patients, and a closer examination found it to be overexpressed in bronchoalveolar macrophages from COPD patients, as well as the bronchial epithelium and inflammatory cells in the lamina propria...
2016: PloS One
https://www.readbyqxmd.com/read/27911810/in-vivo-bioluminescence-imaging-reveals-copper-deficiency-in-a-murine-model-of-nonalcoholic-fatty-liver-disease
#20
Marie C Heffern, Hyo Min Park, Ho Yu Au-Yeung, Genevieve C Van de Bittner, Cheri M Ackerman, Andreas Stahl, Christopher J Chang
Copper is a required metal nutrient for life, but global or local alterations in its homeostasis are linked to diseases spanning genetic and metabolic disorders to cancer and neurodegeneration. Technologies that enable longitudinal in vivo monitoring of dynamic copper pools can help meet the need to study the complex interplay between copper status, health, and disease in the same living organism over time. Here, we present the synthesis, characterization, and in vivo imaging applications of Copper-Caged Luciferin-1 (CCL-1), a bioluminescent reporter for tissue-specific copper visualization in living animals...
December 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
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