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https://www.readbyqxmd.com/read/28646427/tanshinone-iia-attenuates-atherosclerosis-in-apolipoprotein-e-knockout-mice-infected-with-porphyromonas-gingivalis
#1
Yan Xuan, Yue Gao, Hao Huang, Xiaoxuan Wang, Yu Cai, Qing Xian Luan
Tanshinone IIA (TSA), a pharmacologically active component isolated from Danshen, may prevent cardiovascular diseases due to its anti-inflammatory, anti-oxidative, and anti-adipogenic effects. Porphyromonas gingivalis, a major periodontal pathogen, may contribute to the progression of atherosclerosis. Here, we studied the effects of TSA on atherosclerosis in ApoE(-/-) mice with P. gingivalis infection. Eight-week-old ApoE(-/-) mice were randomized to (a) phosphate-buffered saline (PBS), (b) P. gingivalis, and (c) P...
June 23, 2017: Inflammation
https://www.readbyqxmd.com/read/28637471/enhanced-humoural-and-cellular-immune-responses-to-influenza-h7n9-antigen-ha1-2-fused-with-flagellin-in-chickens
#2
Li Song, Dan Xiong, Maozhi Hu, Xilong Kang, Zhiming Pan, Xinan Jiao
BACKGROUND: Sudden increases in the number of human A (H7N9) cases reported during December and January have been observed in previous years. Most reported infection cases are due to prior exposure to live poultry or potentially contaminated environments. Low pathogenicity of influenza A (H7N9) virus in avian species complicates timely discovery of infected birds. Therefore, there is a pressing need to develop safe and effective anti-H7N9 vaccines for poultry to reduce the risk of human infection and prevent the emergence of novel mutated strains...
June 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28631748/ccl-2-as-a-possible-early-marker-for-remission-after-traumatic-spinal-cord-injury
#3
R A Heller, T F Raven, T Swing, K Kunzmann, V Daniel, P Haubruck, M Akbar, P A Grützner, G Schmidmaier, B Biglari, A Moghaddam
STUDY DESIGN: Prospective observational study. OBJECTIVES: To describe the correlation between CCL-2, CCL-3, CCL-4 and CXCL-5 serum levels and remission after traumatic spinal cord injury (SCI) in a human protocol compared with animal studies. SETTING: Germany, Rhineland-Palatinate (Rheinland-Pfalz). METHODS: We examined the serum levels of CCL-2, CCL-3, CCL-4 and CXCL-5 over a 12-week period; in particular, at admission and 4, 9 and 12 h, 1 and 3 days and 1, 2, 4, 8 and 12 weeks after trauma...
June 20, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28621599/comparison-of-ultrasonography-and-magnetic-resonance-imaging-to-arthroscopy-for-diagnosing-medial-meniscal-lesions-in-dogs-with-cranial-cruciate-ligament-deficiency
#4
Samuel P Franklin, James L Cook, Cristi R Cook, Layla S Shaikh, Kevin M Clarke, Shannon P Holmes
OBJECTIVE To compare the accuracy of ultrasonography and MRI for diagnosing medial meniscal lesions in dogs with cranial cruciate ligament (CCL) deficiency. DESIGN Diagnostic test evaluation. ANIMALS 26 dogs (31 stifle joints) with CCL deficiency. PROCEDURES A single surgeon physically examined each dog and performed ultrasonography and arthroscopy of affected stifle joints to identify medial meniscal lesions. Video recordings of the arthroscopic procedure were saved and subsequently reviewed by the same surgeon and by a second surgeon working independently and blinded to results of all examinations...
July 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28618861/potentially-probiotic-lactobacillus-strains-with-anti-proliferative-activity-induce-cytokine-chemokine-production-and-neutrophil-recruitment-in-mice
#5
G Saxami, A Karapetsas, P Chondrou, S Vasiliadis, E Lamprianidou, I Kotsianidis, P Ypsilantis, S Botaitis, C Simopoulos, A Galanis
Lactobacillus pentosus B281 and Lactobacillus plantarum B282 are two Lactobacillus strains previously isolated from fermented table olives. Both strains were found to possess probiotic properties and displayed desirable technological characteristics for application as starters in novel functional food production. In the present study the anti-proliferative and immunostimulatory activities of the two strains were investigated. Firstly, we demonstrated that live L. pentosus B281 and L. plantarum B282 significantly inhibited the growth of human colon cancer cells (Caco-2) in a time- and dose-dependent manner...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28617329/hepatoprotective-effect-of-aqueous-extract-from-the-seeds-of-orychophragmus-violaceus-against-liver-injury-in-mice-and-hepg2-cells
#6
Xiaowei Huo, Chenqi Liu, Li Gao, Xudong Xu, Nailiang Zhu, Li Cao
Orychophragmus violaceus (O. violaceus) is a kind of edible wild herb in north China and its seeds have medical potential, however, the effect of O. violaceus seeds on liver injury and the mechanism of action remains poorly understood. Thus, the purpose of the present study is to investigate the effect of O. violaceus seeds on liver injury and further explore the molecular mechanism of the beneficial effects using aqueous extract from the seeds of O. violaceus (AEOV). Mice were orally administrated with saline, AEOV, and biphenyldicarboxylate for 4 days, and were then injected subcutaneously with 0...
June 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28612257/peripheral-alterations-in-cytokine-and-chemokine-levels-after-antidepressant-drug-treatment-for-major-depressive-disorder-systematic-review-and-meta-analysis
#7
REVIEW
Cristiano A Köhler, Thiago H Freitas, Brendon Stubbs, Michael Maes, Marco Solmi, Nicola Veronese, Nayanna Q de Andrade, Gerwyn Morris, Brisa S Fernandes, André R Brunoni, Nathan Herrmann, Charles L Raison, Brian J Miller, Krista L Lanctôt, André F Carvalho
Mounting evidence suggests that aberrations in immune-inflammatory pathways contribute to the pathophysiology of major depressive disorder (MDD), and individuals with MDD may have elevated levels of predominantly pro-inflammatory cytokines and C-reactive protein. In addition, previous meta-analyses suggest that antidepressant drug treatment may decrease peripheral levels of interleukin-1 beta (IL-1β) and IL-6. Recently, several new studies examining the effect of antidepressants on these cytokines have been published, and so we performed an updated meta-analysis of studies that measured peripheral levels of cytokines and chemokines during antidepressant treatment in patients with MDD...
June 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28600710/the-influence-of-systemic-renin-angiotensin-inhibition-on-ocular-cytokines-related-to-proliferative-vitreoretinopathy
#8
Robert Hoerster, Sascha Fauser, Claus Cursiefen, Bernd Kirchhof, Ludwig M Heindl
PURPOSE: The renin-angiotensin system is involved in the pathogenesis of fibrosis in several organs via induction of transforming growth factor (TGF) beta. In the pathogenesis of proliferative vitreoretinopathy (PVR) TGF-beta plays a pivotal role, promoting transition of retinal pigment epithelial (RPE) cells into myofibroblasts. We studied the influence of angiotensin converting enzyme-inhibition (ACEI) on cytokines and growth factors, related to PVR in aqueous humor. METHODS: We performed a post hoc analysis of a prospectively conducted interventional case series...
June 9, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28596474/lenalidomide-increases-human-dendritic-cell-maturation-in-multiple-myeloma-patients-targeting-monocyte-differentiation-and-modulating-mesenchymal-stromal-cell-inhibitory-properties
#9
Federica Costa, Rosanna Vescovini, Marina Bolzoni, Valentina Marchica, Paola Storti, Denise Toscani, Fabrizio Accardi, Laura Notarfranchi, Benedetta Dalla Palma, Cristina Manferdini, Sabrina Manni, Giannalisa Todaro, Gina Lisignoli, Francesco Piazza, Franco Aversa, Nicola Giuliani
The use of Lenalidomide (LEN), to reverse tumor-mediated immune suppression and amplify multiple myeloma-specific immunity is currently being explored. Particularly, LEN effects on dendritic cells (DCs) are still unclear. In this study, we investigated the potential effect of LEN on DC differentiation and activity. DCs were differentiated either from CD14+ cells obtained from patients with multiple myeloma or from a human monocytic cell line.LEN, at the concentration range reached in vivo, significantly increased the median intensity expression of HLA-DR, CD86 and CD209 by DCs derived from both bone marrow and peripheral myeloma monocytes and enhanced the production of Interleukin-8, C-C motif chemokine ligand (CCL) 2, CCL5 and tumor necrosis factor-α...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28585201/the-pathogenesis-of-obesity-associated-adipose-tissue-inflammation
#10
Atilla Engin
Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive fatty acid release may worsen adipose tissue inflammation and contributes to insulin resistance. In this case, several novel and highly active molecules are released abundantly by adipocytes like leptin, resistin, adiponectin or visfatin, as well as some more classical cytokines. Most likely cytokines that are released by inflammatory cells infiltrating obese adipose tissue are such as tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1) (CCL-2) and IL-1...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28583232/effect-of-topical-beclomethasone-on-inflammatory-markers-in-adults-with-eosinophilic-esophagitis-a-pilot-study
#11
Neeti Bhardwaj, Faoud Ishmael, Erik Lehman, Deborah Bethards, Francesca Ruggiero, Gisoo Ghaffari
BACKGROUND: Topical corticosteroids have proven efficacy in the treatment of eosinophilic esophagitis (EoE) and are considered the cornerstone of therapy. OBJECTIVE: To evaluate the effect of topical beclomethasone dipropionate (BDP) therapy on clinical outcomes, esophageal eosinophilia, and other markers of inflammation in patients with EoE. METHODS: Nine subjects with a biopsy-proven diagnosis of EoE were enrolled. In a cross-over design, the subjects were randomly assigned to a sequence of BDP and placebo...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28581995/false-activations-for-st-segment-elevation-myocardial-infarction
#12
REVIEW
David C Lange, Ivan C Rokos, J Lee Garvey, David M Larson, Timothy D Henry
First-medical-contact-to-device (FMC2D) times have improved over the past decade, as have clinical outcomes for patients presenting with ST-elevation myocardial infarction (STEMI). However, with improvements in FMC2D times, false activation of the cardiac catheterization laboratory (CCL) has become a challenging problem. The authors define false activation as any patient who does not warrant emergent coronary angiography for STEMI. In addition to clinical outcome measures for these patients, STEMI systems should collect data regarding the total number of CCL activations, the total number of emergency coronary angiograms, and the number revascularization procedures performed...
October 2016: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28576209/vegf-a-is-increased-in-exogenous-endophthalmitis
#13
Mark E Seamone, Darrell R Lewis, Ian D Haidl, R Rishi Gupta, Daniel M O' Brien, John Dickinson, Arif Samad, Jean S Marshall, Alan F Cruess
OBJECTIVE: Exogenous endophthalmitis is an ophthalmologic emergency defined by panocular inflammation. Vascular endothelial growth factor A (VEGF-A) contributes to inflammation by promoting chemotaxis of monocytes and granulocytes and by increasing vascular permeability. The purpose of this article is to determine if VEGF-A is elevated in the vitreous samples obtained from individuals with exogenous endophthalmitis. METHODS: Vitreous samples from individuals with exogenous endophthalmitis (n = 18) were analyzed via Luminex assay and enzyme-linked immunosorbent assay for the cytokines VEGF-A, tumor necrosis factor (TNF), interleukin 6 (IL-6), IL-8 (chemokine [CXCL]-8), IL-1β, IL-10, IL-12p70, IL-33, interferon (IFN)-γ, IFN-α, IFN-β, chemokine ligand (CCL)-3, IL-2, IL-5, IL-15, CXCL-10, CCL-2, IL-1Ra, CCL-5, IL-17, and CCL-11...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28575534/ccl-2-in-the-circulation-predicts-long-term-progression-of-interstitial-lung-disease-in-early-systemic-sclerosis-patients-data-from-two-independent-cohorts
#14
Minghua Wu, Murray Baron, Claudia Pedroza, Gloria A Salazar, Jun Ying, Julio Charles, Sandeep K Agarwal, Marie Hudson, Janet Pope, Xiaodong Zhou, John D Reveille, Marvin J Fritzler, Maureen D Mayes, Shervin Assassi
OBJECTIVE: There are few clinical predictors of progression of systemic sclerosis (SSc) related interstitial lung disease (ILD). Herein, we examine the predictive significance of key cytokines for long-term progression of ILD and survival in early SSc in two independent cohorts. METHODS: Plasma levels of 11 Th1/Th2 cytokines (IL-1β, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, TNF-α, CCL-2, ITAC and IP-10) were measured in 266 SSc patients in the GENISOS cohort. Next, CCL-2, IL-10, and IL-6 were measured in 171 early SSc patients from the CSRG replication cohort...
June 2, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28566469/visceral-adipose-tissue-activated-macrophage-content-and-inflammatory-adipokine-secretion-is-higher-in-pre-eclampsia-than-in-healthy-pregnancy
#15
Shahzya Huda, FIona Jordan, JAck Bray, Gillian Love, Reba Payne, Naveed Sattar, Dilys J Freeman
Obesity increases preeclampsia risk. Adipose tissue inflammation may contribute to the clinical syndrome of pre-eclampsia. We compared adipose tissue macrophage infiltration and release of pro-inflammatory adipokines in pre-eclampsia and healthy pregnancy. Subcutaneous and visceral adipose tissue biopsies were collected from healthy (n=13) and preeclampsia (n=13) mothers. Basal and lipopolysaccharide stimulated adipocyte TNFα, IL-6, CCL-2 and CRP release was measured. Adipose tissue cell densities of activated (cfms(+)) and total (CD68(+)) macrophages were determined...
May 31, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28560408/collagen-derived-n-acetylated-proline-glycine-proline-upregulates-the-expression-of-pro-inflammatory-cytokines-and-extracellular-matrix-proteases-in-nucleus-pulposus-cells-via-the-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#16
Chencheng Feng, Jinyue He, Yang Zhang, Minghong Lan, Minghui Yang, Huan Liu, Bo Huang, Yong Pan, Yue Zhou
N-acetylated proline-glycine-proline (N-Ac-PGP) is a chemokine involved in inflammatory diseases and is found to accumulate in degenerative discs. N-Ac-PGP has been demonstrated to have a pro-inflammatory effect on human cartilage endplate stem cells. However, the effect of N-Ac-PGP on human intervertebral disc cells, especially nucleus pulposus (NP) cells, remains unknown. The purpose of this study was to investigate the effect of N-Ac-PGP on the expression of pro-inflammatory factors and extracellular matrix (ECM) proteases in NP cells and the molecular mechanism underlying this effect...
May 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28552911/plumbagin-suppresses-chronic-periodontitis-in-rats-via-down-regulation-of-tnf-%C3%AE-il-1%C3%AE-and-il-6-expression
#17
Xin-Yi Zheng, Chuan-Yuan Mao, Han Qiao, Xi Zhang, Li Yu, Ting-Yu Wang, Eryi Lu
Chronic periodontitis (CP) is one of the most common oral diseases, which causes alveolar bone absorption and tooth loss in adults. In this study we aimed to investigate the potential of plumbagin (PL), a widely-investigated active compound extracted from the traditional Chinese herb Plumbago zeylanica L in treating CP. Human periodontal ligament stem cells (PDLSCs) were used for in vitro studies, whereas an animal model of CP was established in SD rats by ligation+Porphyromonas gingivalis (Pg) stimulation...
May 29, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28542575/the-anti-inflammatory-and-antioxidant-effects-of-melatonin-on-lps-stimulated-bovine-mammary-epithelial-cells
#18
Guang-Min Yu, Hirokazu Kubota, Miki Okita, Teruo Maeda
Mastitis is the most prevalent disease in dairy cattle worldwide and not only causes huge economic losses in the dairy industry but also threatens public health. To evaluate the therapeutic potential of melatonin in mastitis, we examined the ability of melatonin to protect bovine mammary epithelial cells (bMECs) from the harmful effects of lipopolysaccharide (LPS). We found that melatonin inhibited the LPS-binding protein-CD14-TLR4 signaling pathway in bMECs, which had opposing effects on pro-inflammatory and anti-inflammatory mediators...
2017: PloS One
https://www.readbyqxmd.com/read/28534985/microarray-analysis-of-differentially-expressed-genes-in-l929-mouse-fibroblast-cells-exposed-to-leptin-and-hypoxia
#19
Ping Ouyang, Sen Wang, He Zhang, Zhigang Huang, Pei Wei, Ye Zhang, Zhuguo Wu, Tao Li
Leptin and hypoxia are pro-fibrotic factors involved in fibrogenesis, however, the gene expression profiles remain to be fully elucidated. The aim of the present study was to investigate the regulatory roles of leptin and hypoxia on the L929 mouse fibroblast cell line. The cells were assigned to a normoxia, normoxia with leptin, hypoxia, and hypoxia with leptin group. The cDNA expression was detected using an Agilent mRNA array platform. The differentially expressed genes (DEGs) in response to leptin and hypoxia were identified using reverse transcription‑quantitative polymerase chain reaction analysis, followed by clustering analysis, Gene Ontology analysis and pathway analysis...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28526351/docosahexaenoyl-serotonin-emerges-as-most-potent-inhibitor-of-il-17-and-ccl-20-released-by-blood-mononuclear-cells-from-a-series-of-n-acyl-serotonins-identified-in-human-intestinal-tissue
#20
Ya Wang, Michiel G J Balvers, Henk F J Hendriks, Tessa Wilpshaar, Tjarda van Heek, Renger F Witkamp, Jocelijn Meijerink
Fatty acid amides (FAAs), conjugates of fatty acids with ethanolamine, mono-amine neurotransmitters or amino acids are a class of molecules that display diverse functional roles in different cells and tissues. Recently we reported that one of the serotonin-fatty acid conjugates, docosahexaenoyl serotonin (DHA-5-HT), previously found in gut tissue of mouse and pig, attenuates the IL-23-IL-17 signaling axis in LPS-stimulated mice macrophages. However, its presence and effects in humans remained to be elucidated...
May 16, 2017: Biochimica et Biophysica Acta
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