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https://www.readbyqxmd.com/read/28430671/elevated-production-of-nociceptive-cc-chemokines-and-se-selectin-in-patients-with-low-back-pain-and-the-effects-of-spinal-manipulation-a-non-randomized-clinical-trial
#1
Julita A Teodorczyk-Injeyan, Marion McGregor, John J Triano, H Stephen Injeyan
BACKGROUND: The involvement of inflammatory components in the pathophysiology of low back pain is poorly understood. It has been suggested that spinal manipulative therapy (SMT) may exert anti-inflammatory effects. PURPOSE: To determine the involvement of inflammation-associated chemokines (CC series) in the pathogenesis of non-specific low back pain and to evaluate the effect of SMT on that process. METHODS: Patients presenting with non-radicular, non-specific low back pain (minimum pain score 3 on 10 point visual analogue scale, VAS) were recruited according to stringent inclusion criteria...
April 19, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28420351/prognostic-significance-of-trail-r3-and-ccr-2-expression-in-tumor-epithelial-cells-of-patients-with-early-breast-cancer
#2
Vivian Labovsky, Leandro Marcelo Martinez, Kevin Mauro Davies, María de Luján Calcagno, Hernán García-Rivello, Alejandra Wernicke, Leonardo Feldman, Ayelén Matas, María Belén Giorello, Francisco Raúl Borzone, Hosoon Choi, Scott C Howard, Norma Alejandra Chasseing
BACKGROUND: Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator of nuclear factor kappa B ligand, stromal cell derived factor-1, interleukin-6, macrophage colony stimulating factor, chemokine (C-C motif) ligand-2 (CCL-2) and their receptors at significantly higher levels compared with non-neoplastic breast tissues...
April 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28418988/hiv-specific-cd8-t-cells-producing-ccl-4-are-associated-with-worse-immune-reconstitution-during-chronic-infection
#3
Rita Casetti, Carmela Pinnetti, Alessandra Sacchi, Gabriele De Simone, Veronica Bordoni, Eleonora Cimini, Nicola Tumino, Francesca Besi, Domenico Viola, Federica Turchi, Valentina Mazzotta, Andrea Antinori, Federico Martini, Adriana Ammassari, Chiara Agrati
BACKGROUND: Immunological non response represents the Achilles heel in the combination antiretroviral treatment (cART) effectiveness, and increases risk of clinical events and death. CD8 T cells play a crucial role in controlling HIV replication and polyfunctional HIV-specific CD8 T cells have been associated with non-progressive HIV infection. However, the possible role of polyfunctional CD8 T cells in predicting post-treatment immune reconstitution has not yet been explored. The aim of this study was to identify functional markers predictive of immunological response to cART in chronic HIV-infected patients...
April 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28415721/robust-in-silico-identification-of-cancer-cell-lines-based-on-next-generation-sequencing
#4
Raik Otto, Christine Sers, Ulf Leser
Cancer cell lines (CCL) are important tools for cancer researchers world-wide. However, handling of cancer cell lines is error-prone, and critical errors such as misidentification and cross-contamination occur more often than acceptable. Based on the fact that CCL today very often are sequenced (partly or entirely) anyway as part of the studies performed, we developed Uniquorn, a computational method that reliably identifies CCL samples based on variant profiles derived from whole exome or whole genome sequencing...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413983/peripheral-blood-mononuclear-cells-of-alzheimer-s-disease-patients-control-ccl4-and-cxcl10-levels-in-a-human-blood-brain-barrier-model
#5
Julie Vérité, Thierry Janet, Adrien Julian, Damien Chassaing, Guylène Page, Marc Paccalin
BACKGROUND: Alzheimer's disease (AD) is accompanied by a neuroinflammation triggering chemoattractant signals towards peripheral blood mononuclear cells (PBMCs), in turn could reduce amyloid plaques after transmigration through the blood brain barrier (BBB). But the chemotactic environment remains unclear. OBJECTIVE: To analyze five chemokines known to be involved in AD in three different cellular models to better understand the cellular and molecular interactions in the BBB...
April 17, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28409543/ccr-2-neutralization-augments-murine-fresh-bmc-activation-by-staphylococcus-aureus-via-two-distinct-mechanisms-at-the-level-of-ros-production-and-cytokine-response
#6
Ajeya Nandi, Biswadev Bishayi
CCR-2 signaling regulates recruitment of monocytes from the bone marrow into the bloodstream and then to sites of infection. We sought to determine whether CCL-2/CCR-2 signaling is involved in the killing of Staphylococcus aureus by murine bone marrow cells (BMCs). The intermittent link of reactive oxygen species (ROS)-NF-κB/p38-MAPK-mediated CCL-2 production in CCR-2 signaling prompted us to determine whether neutralization of CCR-2 augments the response of murine fresh BMCs (FBMCs) after S. aureus infection...
May 2017: Innate Immunity
https://www.readbyqxmd.com/read/28406452/suppression-of-hepatic-epithelial-to-mesenchymal-transition-by-melittin-via-blocking-of-tgf%C3%AE-smad-and-mapk-jnk-signaling-pathways
#7
Ji-Hyun Park, Byoungduck Park, Kwan-Kyu Park
Transforming growth factor (TGF)-β1 plays a crucial role in the epithelial-to-mesenchymal transition (EMT) in hepatocytes and hepatic stellate cells (HSC), which contributes to the pathogenesis of liver fibrosis. Melittin (MEL) is a major component of bee venom and is effective in rheumatoid arthritis, pain relief, cancer cell proliferation, fibrosis and immune modulating activity. In this study, we found that MEL inhibits hepatic EMT in vitro and in vivo, regulating the TGFβ/Smad and TGFβ/nonSmad signaling pathways...
April 13, 2017: Toxins
https://www.readbyqxmd.com/read/28397427/the-analysis-of-cytotoxicity-of-an-experimental-preparation-used-for-the-reduction-of-dentin-hypersensitivity
#8
Marta Tanasiewicz, Małgorzata Skucha-Nowak, Mirosław Gibas, Justyna Pawlak, Włodzimierz Więckiewicz, Anna Mertas, Wojciech Król
BACKGROUND: The problem of effective treatment of dentin hypersensitivity is still valid and not fully resolved. OBJECTIVES: The aim of the study was to evaluate the potential toxicity against body tissues of an experimental preparation which is supposed to reduce dentin hypersensitivity and to compare it to a commercial formulation Seal & Protect (Dentsply) by means of measuring the activity of mitochondrial dehydrogenases (the MTT assay). MATERIAL AND METHODS: The study used an original protective formulation which is supposed to eliminate hypersensitivity of dentin...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28393189/upregulation-of-heme-oxygenase-1-in-kupffer-cells-blocks-mast-cell-degranulation-and-inhibits-dendritic-cell-migration-in%C3%A2-vitro
#9
Yuan-Yuan Ma, Mu-Qing Yang, Zhi-Gang He, Mao-Hong Fan, Man Huang, Fei Teng, Qing Wei, Ji-Yu Li
Kupffer cells (KCs) influence liver allografts by interacting with other non‑parenchymal cells. However, the exact mechanism remains unclear. Upregulation of heme oxygenase-1 (HO-1) in KCs upon interaction with mast cells (MCs), and the effects on dendritic cell (DC) function, were investigated in the present study. KCs, MCs and DCs were prepared from 8‑10‑week‑old C57BL/6 mice. KCs were pretreated with PBS, dimethyl sulfoxide, hemin (50 µM; HO‑1 inducer), and zinc protoporphyrin (50 µM; HO‑1 inhibitor) for 8 h...
April 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28383514/fraxin-prevents-chemically-induced-hepatotoxicity-by-reducing-oxidative-stress
#10
Bo Yoon Chang, Young Suk Jung, Chi-Su Yoon, Jun Seok Oh, Jae Heoi Hong, Youn-Chul Kim, Sung Yeon Kim
Fraxin isolated from Acer tegmentosum is reported to exert potent anti-oxidative stress action. However, pharmacological activities of fraxin remain to be elucidated. This study investigated the potential hepatoprotective effects of fraxin and the underlying signaling mechanism involved. Treatment with fraxin significantly lowered the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a CCl₄-induced hepatotoxicity rat model. In the fraxin-treated group, glutathione (GSH) significantly increased, while the malondialdehyde (MDA) in the liver significantly decreased...
April 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28377296/mechanical-chest-compressions-improve-rate-of-return-of-spontaneous-circulation-and-allow-for-initiation-of-percutaneous-circulatory-support-during-cardiac-arrest-in-the-cardiac-catheterization-laboratory
#11
Joseph M Venturini, Elizabeth Retzer, J Raider Estrada, Janet Friant, David Beiser, Dana Edelson, Jonathan Paul, John Blair, Sandeep Nathan, Atman P Shah
BACKGROUND: Performing advanced cardiac life support (ACLS) in the cardiac catheterization laboratory (CCL) is challenging. Mechanical chest compression (MCC) devices deliver compressions in a small space, allowing for simultaneous percutaneous coronary intervention and reduced radiation exposure to rescuers. In refractory cases, MCC devices allow rescuers to initiate percutaneous mechanical circulatory support (MCS) and extracorporeal life support (ECLS) during resuscitation. This study sought to assess the efficacy and safety of MCC when compared to manual compressions in the CCL...
April 2, 2017: Resuscitation
https://www.readbyqxmd.com/read/28370152/long-term-outcome-of-an-intra-articular-allograft-technique-for-treatment-of-spontaneous-cranial-cruciate-ligament-rupture-in-the-dog
#12
Jeffery J Biskup, Daniel G Balogh, Ruth M Scott, Michael G Conzemius
OBJECTIVE: To determine the 12-month outcome in dogs with spontaneous cranial cruciate ligament (CCL) rupture after repair with an intra-articular decellularized allograft. STUDY DESIGN: Prospective pilot case series. ANIMALS: Ten client-owned dogs with unilateral CCL rupture. METHODS: An intra-articular, decellularized, deep digital flexor tendon allograft was secured in the stifle with a femoral cross pin and tibial spiked washers and screws...
March 31, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28369965/canine-cranial-cruciate-ligament-deficient-stifle-biomechanics-associated-with-extra-articular-stabilization-predicted-using-a-computer-model
#13
Nathan P Brown, Gina E Bertocci, Denis J Marcellin-Little
OBJECTIVE: To evaluate lateral fabellotibial suture (LFTS) and TightRope CCL (TR) extra-articular stabilization biomechanics in the cranial cruciate ligament (CrCL)-deficient canine stifle joint during the stance phase of gait. STUDY DESIGN: Computer simulations. ANIMALS: Healthy 33-kg Golden Retriever. METHODS: LFTS and TR were implemented in a previously developed 3-D quasi-static rigid body CrCL-deficient canine pelvic limb computer model simulating the stance phase of gait...
April 1, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28364916/transforming-cold-chain-performance-and-management-in-lower-income-countries
#14
Mike Brison, Yann LeTallec
In many countries, one of the common factors limiting full and equitable access to effective immunization is the existence of gaps in cold chain and logistics (CCL) systems. This article focuses on the critical contribution that better management of CCL performance can make in addressing these barriers, as well as some essential practices needed to achieve and sustain these gains. These include (i) an emphasis on continuous improvement in CCL performance indicators, (ii) strong coordination and accountability across multiple stakeholders, and (iii) making the most of limited financial resources...
April 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28363077/examining-the-preference-for-shade-structures-in-farmed-green-sea-turtles-chelonia-mydas-and-shade-s-effect-on-growth-and-temperatures
#15
Martha Keller, Walter Mustin
The Cayman Turtle Farm raises thousands of green sea turtles ( Chelonia mydas ) annually under aquaculture conditions. Historically, the turtles have been raised in tanks without routine access to a shade structure. The purpose of this study was to determine the effects of adding a shade structure on curved carapace length (CCL) and weight gain of green sea turtles. In addition, water and cloacal temperatures were compared across treatment groups and shade cover preferences observed. Ninety turtles were split equally into three treatment groups for this 8-wk study...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28346888/oxidative-and-nitrosative-stress-biomarkers-in-chronic-schizophrenia
#16
Karine Maria Boll, Cristiano Noto, Kamila Landucci Bonifácio, Chiara Cristina Bortolasci, Ary Gadelha, Rodrigo Affonseca Bressan, Décio Sabbatini Barbosa, Michael Maes, Estefania Gastaldello Moreira
There is evidence that the acute phase of schizophrenia (SCZ) is accompanied by specific changes in oxidative and nitrosative stress (O&NS) biomarkers. There are, however, no firm data regarding these biomarkers in chronic SCZ. Therefore, this study aimed to delineate O&NS biomarkers in patients with chronic SCZ. 125 outpatients with SCZ and 118 controls were enrolled. The markers included lipid hydroperoxides (LOOH), advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP) and paraoxonase 1 (PON-1) activity...
March 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28342872/covalent-conjugation-of-the-equine-infectious-anemia-virus-gag-with-sumo
#17
Jinzhong Wang, Shuping Wen, Rui Zhao, Jing Qi, Zhao Liu, Weiwei Li, Jing An, Charles Wood, Ying Wang
The conjugation of small ubiquitin-like modifier (SUMO) to the target protein, namely, SUMOylation, is involved in the regulation of many important biological events including host-pathogen interaction. Some viruses have evolved to exploit the host SUMOylation machinery to modify their own protein. Retroviral Gag protein plays critical roles in the viral life cycle. The HIV-1 p6 and the Moloney murine leukemia virus CA have been reported to be conjugated with SUMO. In this study, we report for the first time, to our knowledge, the covalent conjugation of equine infectious anemia virus (EIAV) Gag with SUMO...
March 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28339247/thermodynamic-and-kinetic-fragility-of-freon-113-the-most-fragile-plastic-crystal
#18
A Vispa, M Romanini, M A Ramos, L C Pardo, F J Bermejo, M Hassaine, A I Krivchikov, J W Taylor, J Ll Tamarit
We present a dynamic and thermodynamic study of the orientational glass former Freon 113 (1,1,2-trichloro-1,2,2-trifluoroethane, CCl_{2}F-CClF_{2}) in order to analyze its kinetic and thermodynamic fragilities. Freon 113 displays internal molecular degrees of freedom that promote a complex energy landscape. Experimental specific heat and its microscopic origin, the vibrational density of states from inelastic neutron scattering, together with the orientational dynamics obtained by means of dielectric spectroscopy have revealed the highest fragility value, both thermodynamic and kinetic, found for this orientational glass former...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28339195/the-electronic-configuration-and-ligand-nature-of-five-coordinate-iron-porphyrin-carbene-complexes-an-experimental-study
#19
Yulong Liu, Wei Xu, Jing Zhang, William Fuller, Charles E Schulz, Jianfeng Li
The five coordinate iron porphyrin carbene complexes [Fe(TPP)(CCl<u>2</u>)] (TPP = tetraphenylporphyrin), [Fe(TTP)(CCl<u>2</u>)] (TTP = tetratolylporphyrin) and [Fe(TFPP)(CPh<u>2</u>)] (TFPP = tetra(pentafluorophenyl)porphin), utilizing two types of carbene ligands (CCl<u>2</u> and CPh<u>2</u>), have been investigated by single crystal X-ray, XANES (X-ray Absorption Near Edge Spectroscopy), Mössbauer, NMR and UV-vis spectros-copies. The XANES unambiguously suggested the iron(II) oxida-tion state of the complexes...
March 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28333654/cytokine-changes-in-gastric-and-colonic-epithelial-cell-in-response-to-planta-ovata-extract
#20
Javed Yakoob, Wasim Jafri, Malik Hassan Mehmood, Zaigham Abbas, Kanwal Tariq
Background Psyllium (Planta ovata, Ispaghul) seed and husk are used for treatment of altered bowel habit, i. e. constipation and diarrhea. We studied the effect of Ispaghul extract on secretion of interleukin-1 beta (IL-1β) by AGS (ATCC CRL 1739) and SW480 (ATCC CCL-227) epithelial cell lines and determined whether Ispaghul extract has an effect on IL-1β secretion by Helicobacter pylori (H. pylori)-stimulated AGS cell and Escherichia coli K-12 (E. coli K-12)-stimulated SW480 cells in vitro. Methods The AGS cells and SW480 cells were pretreated with Ispaghul extract in concentrations, i...
March 22, 2017: Journal of Complementary & Integrative Medicine
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