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https://www.readbyqxmd.com/read/27862429/c-terminal-modification-and-multimerization-increase-the-efficacy-of-a-proline-rich-antimicrobial-peptide
#1
Wenyi Li, Neil M O'Brien-Simpson, Shenggen Yao, Julien Tailhades, Eric C Reynolds, Raymond M Dawson, Laszlo Otvos, Mohammed Akhter Hossain, Frances Separovic, John D Wade
Two series of branched tetramers of the proline-rich antimicrobial peptide (PrAMP), Chex1-Arg20, were prepared to improve antibacterial selectivity and potency against a panel of Gram-negative nosocomial pathogens including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. First, tetramerization was achieved by dithiomaleimide (DTM) conjugation of two C-terminal-cysteine bearing dimers that also incorporated C-terminal peptide chemical modification. DTM-linked tetrameric peptides containing a C-terminal hydrazide moiety on each dimer exhibited highly potent activities in the minimum inhibitory concentration (MIC) range of 0...
November 16, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27830091/new-indices-of-endothelial-function-measured-by-digital-thermal-monitoring-of-vascular-reactivity-data-from-6084-patients-registry
#2
Morteza Naghavi, Albert A Yen, Alex W H Lin, Hirofumi Tanaka, Stanley Kleis
Background. Endothelial function is viewed as a barometer of cardiovascular health and plays a central role in vascular reactivity. Several studies showed digital thermal monitoring (DTM) as a simple noninvasive method to measure vascular reactivity that is correlated with atherosclerosis risk factors and coronary artery disease. Objectives. To further evaluate the relations between patient characteristics and DTM indices in a large patient registry. Methods. DTM measures were correlated with age, sex, heart rate, and systolic and diastolic blood pressure in 6084 patients from 18 clinics...
2016: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/27828567/factors-associated-with-negative-self-perception-of-oral-health-among-institutionalized-elderly
#3
Laércio Almeida de Melo, Meily de Mello Sousa, Annie Karoline Bezerra de Medeiros, Adriana da Fonte Porto Carreiro, Kenio Costa de Lima
The aim of this study was to determine self-perception of oral-health in institutionalized elderly, and look into the sociodemographic and clinical aspects associated with negative self-perception. One hundred and sixty-six elderly were assessed by answering a self-perception question that predicts the GOHAI (Geriatric Oral Health Assessment Index). Sociodemographic data was obtained from a previously validated questionnaire and clinical data taken from the WHO file and QST-TMD used to check the existence of TMD (temporomandibular disturbance)...
November 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27815243/bmp4-acts-as-a-dorsal-telencephalic-morphogen-in-a-mouse-embryonic-stem-cell-culture-system
#4
Momoko Watanabe, Ernest S Fung, Felicia B Chan, Jessica S Wong, Margaret Coutts, Edwin S Monuki
The concept of a morphogen - a molecule that specifies two or more cell fates in a concentration-dependent manner - is paradigmatic in developmental biology. Much remains unknown, however, about the existence of morphogens in the developing vertebrate CNS, including the mouse dorsal telencephalic midline (DTM). Bone Morphogenetic Proteins (BMPs) are candidate DTM morphogens, and our previous work demonstrated BMP4 sufficiency to induce one DTM cell fate - that of choroid plexus epithelial cells (CPECs) - in a mouse embryonic stem cell (mESC) culture system...
November 4, 2016: Biology Open
https://www.readbyqxmd.com/read/27785895/transcriptome-analysis-of-zebrafish-embryos-exposed-to-deltamethrin
#5
Tsung-Cheng Chueh, Li-Sung Hsu, Chin-Ming Kao, Tung-Wei Hsu, Hung-Yu Liao, Kuan-Yi Wang, Ssu Ching Chen
Deltamethrin (DTM), a type II pyrethroid, is one of the most commonly used insecticides. The increased use of pyrethroid leads to potential adverse effects, particularly in sensitive populations such as children and pregnant women. None of the related studies was focused on the transcriptome responses in zebrafish embryos after treatment with DTM; therefore, RNA-seq, a high-throughput method, was performed to analyze the global expression of differential expressed genes (DEGs) in zebrafish embryos treated with DTM (40 and 80 μg/L) from fertilization to 48 h postfertilization (hpf) as compared with that in the control group (without DTM treatment)...
October 27, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27777859/a-new-multi-step-technique-with-differential-transform-method-for-analytical-solution-of-some-nonlinear-variable-delay-differential-equations
#6
Brahim Benhammouda, Hector Vazquez-Leal
This work presents an analytical solution of some nonlinear delay differential equations (DDEs) with variable delays. Such DDEs are difficult to treat numerically and cannot be solved by existing general purpose codes. A new method of steps combined with the differential transform method (DTM) is proposed as a powerful tool to solve these DDEs. This method reduces the DDEs to ordinary differential equations that are then solved by the DTM. Furthermore, we show that the solutions can be improved by Laplace-Padé resummation method...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27766956/application-of-dynamic-topic-models-to-toxicogenomics-data
#7
Mikyung Lee, Zhichao Liu, Ruili Huang, Weida Tong
BACKGROUND: All biological processes are inherently dynamic. Biological systems evolve transiently or sustainably according to sequential time points after perturbation by environment insults, drugs and chemicals. Investigating the temporal behavior of molecular events has been an important subject to understand the underlying mechanisms governing the biological system in response to, such as, drug treatment. The intrinsic complexity of time series data requires appropriate computational algorithms for data interpretation...
October 6, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27670688/simultaneous-proteomic-discovery-and-targeted-monitoring-using-liquid-chromatography-ion-mobility-spectrometry-and-mass-spectrometry
#8
Kristin E Burnum-Johnson, Song Nie, Cameron P Casey, Matthew E Monroe, Daniel J Orton, Yehia M Ibrahim, Marina A Gritsenko, Therese R W Clauss, Anil K Shukla, Ronald J Moore, Samuel O Purvine, Tujin Shi, Weijun Qian, Tao Liu, Erin S Baker, Richard D Smith
Current proteomic approaches include both broad discovery measurements and quantitative targeted analyses. In many cases, discovery measurements are initially used to identify potentially important proteins (e.g. candidate biomarkers) and then targeted studies are employed to quantify a limited number of selected proteins. Both approaches, however, suffer from limitations. Discovery measurements aim to sample the whole proteome but have lower sensitivity, accuracy, and quantitation precision than targeted approaches, whereas targeted measurements are significantly more sensitive but only sample a limited portion of the proteome...
December 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27619649/in-vivo-precision-of-three-hr-pqct-derived-finite-element-models-of-the-distal-radius-and-tibia-in-postmenopausal-women
#9
C E Kawalilak, S A Kontulainen, M A Amini, J L Lanovaz, W P Olszynski, J D Johnston
BACKGROUND: The distal radius is the most common osteoporotic fracture site occurring in postmenopausal women. Finite element (FE) modeling is a non-invasive mathematical technique that can estimate bone strength using inputted geometry/micro-architecture and tissue material properties from computed tomographic images. Our first objective was to define and compare in vivo precision errors for three high-resolution peripheral quantitative computed tomography (HR-pQCT, XtremeCT; Scanco) based FE models of the distal radius and tibia in postmenopausal women...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27610116/screening-of-bread-wheat-genotypes-for-drought-tolerance-using-phenotypic-and-proline-analyses
#10
Learnmore Mwadzingeni, Hussein Shimelis, Samson Tesfay, Toi J Tsilo
Drought stress is one of the leading constraints to wheat (Triticum aestivum L.) production globally. Breeding for drought tolerance using novel genetic resources is an important mitigation strategy. This study aimed to determine the level of drought tolerance among diverse bread wheat genotypes using agronomic traits and proline analyses and to establish correlation of proline content and agronomic traits under drought-stress conditions in order to select promising wheat lines for breeding. Ninety-six diverse genotypes including 88 lines from the International Maize and Wheat Improvement Center (CIMMYT)'s heat and drought nurseries, and eight local checks were evaluated under greenhouse and field conditions during 2014/15 and 2015/16 making four testing environments...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27584031/detecting-precontact-anthropogenic-microtopographic-features-in-a-forested-landscape-with-lidar-a-case-study-from-the-upper-great-lakes-region-ad-1000-1600
#11
Meghan C L Howey, Franklin B Sullivan, Jason Tallant, Robert Vande Kopple, Michael W Palace
Forested settings present challenges for understanding the full extent of past human landscape modifications. Field-based archaeological reconnaissance in forests is low-efficiency and most remote sensing techniques are of limited utility, and together, this means many past sites and features in forests are unknown. Archaeologists have increasingly used light detection and ranging (lidar), a remote sensing tool that uses pulses of light to measure reflecting surfaces at high spatial resolution, to address these limitations...
2016: PloS One
https://www.readbyqxmd.com/read/27568310/drug-therapy-management-in-patients-with-renal-impairment-how-to-use-creatinine-based-formulas-in-clinical-practice
#12
Willemijn L Eppenga, Cornelis Kramers, Hieronymus J Derijks, Michel Wensing, Jack F M Wetzels, Peter A G M De Smet
PURPOSE: The use of estimated glomerular filtration rate (eGFR) in daily clinical practice. METHODS: eGFR is a key component in drug therapy management (DTM) in patients with renal impairment. eGFR is routinely reported by laboratories whenever a serum creatinine testing is ordered. In this paper, we will discuss how to use eGFR knowing the limitations of serum creatinine-based formulas. RESULTS: Before starting a renally excreted drug, an equally effective drug which can be used more safely in patients with renal impairment should be considered...
December 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27486059/direct-catalytic-asymmetric-mannich-reaction-with-dithiomalonates-as-excellent-mannich-donors-organocatalytic-synthesis-of-r-sitagliptin
#13
Han Yong Bae, Mun Jong Kim, Jae Hun Sim, Choong Eui Song
In this study, dithiomalonates (DTMs) were demonstrated to be exceptionally efficient Mannich donors in terms of reactivity and stereoselectivity in cinchona-based-squaramide-catalyzed enantioselective Mannich reactions of diverse imines or α-amidosulfones as imine surrogates. Owing to the superior reactivity of DTMs as compared to conventional malonates, the catalyst loading could be reduced to 0.1 mol % without the erosion of enantioselectivity (up to 99 % ee). Furthermore, by the use of a DTM, even some highly challenging primary alkyl α-amidosulfones were smoothly converted into the desired adducts with excellent enantioselectivity (up to 97 % ee), whereas the use of a malonate or monothiomalonate resulted in no reaction under identical conditions...
August 26, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27387553/self-rating-of-daily-time-management-in-children-psychometric-properties-of-the-time-s
#14
Annika Sköld, Gunnel Kristina Janeslätt
BACKGROUND: Impaired ability to manage time has been shown in several diagnoses common in childhood. Impaired ability involves activities and participation domain (daily time management, DTM) and body function and structure domain (time-processing ability, TPA). DTM needs to be evaluated from an individual's own perspective. To date, there has been a lack of self-rating instruments for children that focus on DTM. AIM: The aim of this study is to describe psychometric properties of Time-S when used in children aged 10-17 years with a diagnosis of ADHD, Autism, CP or mild ID...
July 8, 2016: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/27332424/textual-analysis-and-data-mining-an-interpreting-research-on-nursing
#15
W De Caro, L Mitello, A R Marucci, L Lancia, J Sansoni
Every day there is a data explosion on the web. In 2013, 5 exabytes of content were created each day. Every hour internet networks carries a quantity of texts equivalent to twenty billion books. For idea Iit is a huge mass of information on the linguistic behavior of people and society that was unthinkable until a few years ago. It is an opportunity for valuable analysis for understanding social phenomena, also in nursing and health care sector.This poster shows the the steps of an idealy strategy for textual statistical analysis and the process of extracting useful information about health care, referring expecially nursing care from journal and web information...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27264904/early-controlled-mobilization-using-dart-throwing-motion-with-a-twist-for-the-conservative-management-of-an-intra-articular-distal-radius-fracture-and-scapholunate-ligament-injury-a-case-report
#16
Lynne Feehan, Trevor Fraser
UNLABELLED: This case describes an early controlled mobilization (ECM) approach that uses dart-throwing motion (DTM) with a twist orthoses as an alternative to immobilization for conservative management of a minimally displaced and intra-articular distal radius styloid fracture with an associated scapholunate ligament injury in a 47-year-old female health care administrator (JP). Pain-free active DTM began at day 10 (5 times/d) with a dynamic DTM with a twist orthosis worn during the day from weeks 3 to 6...
April 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27237544/comparison-between-point-of-care-dermatophyte-test-medium-and-mycology-laboratory-culture-for-diagnosis-of-dermatophytosis-in-dogs-and-cats
#17
Ronnie Kaufmann, Shlomo E Blum, Daniel Elad, Gila Zur
BACKGROUND: Point-of-care Dermatophyte Test Medium (PoC-DTM) is a diagnostic procedure to rule in/rule out dermatophytosis in veterinary clinics. OBJECTIVE: To evaluate the performance of PoC-DTM in the clinic compared to DTM plate culture in a mycology laboratory and to compare results obtained by general practitioners and referral clinicians. ANIMALS: Hair samples were collected from 47 cats and 54 dogs with suspected dermatophytosis and from nine healthy controls (seven cats and two dogs)...
August 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27172218/genomic-prediction-of-gene-bank-wheat-landraces
#18
José Crossa, Diego Jarquín, Jorge Franco, Paulino Pérez-Rodríguez, Juan Burgueño, Carolina Saint-Pierre, Prashant Vikram, Carolina Sansaloni, Cesar Petroli, Deniz Akdemir, Clay Sneller, Matthew Reynolds, Maria Tattaris, Thomas Payne, Carlos Guzman, Roberto J Peña, Peter Wenzl, Sukhwinder Singh
This study examines genomic prediction within 8416 Mexican landrace accessions and 2403 Iranian landrace accessions stored in gene banks. The Mexican and Iranian collections were evaluated in separate field trials, including an optimum environment for several traits, and in two separate environments (drought, D and heat, H) for the highly heritable traits, days to heading (DTH), and days to maturity (DTM). Analyses accounting and not accounting for population structure were performed. Genomic prediction models include genotype × environment interaction (G × E)...
2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27170319/genomic-prediction-for-grain-zinc-and-iron-concentrations-in-spring-wheat
#19
Govindan Velu, Jose Crossa, Ravi P Singh, Yuanfeng Hao, Susanne Dreisigacker, Paulino Perez-Rodriguez, Arun K Joshi, Ravish Chatrath, Vikas Gupta, Arun Balasubramaniam, Chhavi Tiwari, Vinod K Mishra, Virinder Singh Sohu, Gurvinder Singh Mavi
Predictability estimated through cross-validation approach showed moderate to high level; hence, genomic selection approach holds great potential for biofortification breeding to enhance grain zinc and iron concentrations in wheat. Wheat (Triticum aestivum L.) is a major staple crop, providing 20 % of dietary energy and protein consumption worldwide. It is an important source of mineral micronutrients such as zinc (Zn) and iron (Fe) for resource poor consumers. Genomic selection (GS) approaches have great potential to accelerate development of Fe- and Zn-enriched wheat...
August 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27112271/orthotic-intervention-incorporating-the-dart-thrower-s-motion-as-part-of-conservative-management-guidelines-for-treatment-of-scapholunate-injury
#20
Hamish Anderson, Greg Hoy
STUDY DESIGN: Case series. INTRODUCTION: This paper describes conservative guidelines for the management of scapho-lunate interosseous ligament (SLIL) injury including fabrication of an orthosis that restricts active wrist movement to the dart-throwers (DTM) plane. PURPOSE OF THE STUDY: The dart throwers' orthosis (DTO) was designed as a response to biomechanical studies suggesting that restraining motion to the DTM would off-load a deficient SLIL...
April 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
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