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Mikyung Lee, Zhichao Liu, Ruili Huang, Weida Tong
BACKGROUND: All biological processes are inherently dynamic. Biological systems evolve transiently or sustainably according to sequential time points after perturbation by environment insults, drugs and chemicals. Investigating the temporal behavior of molecular events has been an important subject to understand the underlying mechanisms governing the biological system in response to, such as, drug treatment. The intrinsic complexity of time series data requires appropriate computational algorithms for data interpretation...
October 6, 2016: BMC Bioinformatics
Kristin E Burnum-Johnson, Song Nie, Cameron P Casey, Matthew E Monroe, Daniel J Orton, Yehia M Ibrahim, Marina A Gritsenko, Therese R W Clauss, Anil K Shukla, Ronald J Moore, Samuel O Purvine, Tujin Shi, Weijun Qian, Tao Liu, Erin S Baker, Richard D Smith
Current proteomic approaches are comprised of both broad discovery measurements and quantitative targeted analyses. In many cases, discovery measurements are initially used to identify potentially important proteins (e.g., candidate biomarkers) and then targeted studies are employed to quantify a limited number of selected proteins. Both approaches, however, suffer from limitations. Discovery measurements aim to sample the whole proteome but have lower sensitivity, accuracy, and quantitation precision than targeted approaches, while targeted measurements are significantly more sensitive but only sample a limited portion of the proteome...
September 25, 2016: Molecular & Cellular Proteomics: MCP
C E Kawalilak, S A Kontulainen, M A Amini, J L Lanovaz, W P Olszynski, J D Johnston
BACKGROUND: The distal radius is the most common osteoporotic fracture site occurring in postmenopausal women. Finite element (FE) modeling is a non-invasive mathematical technique that can estimate bone strength using inputted geometry/micro-architecture and tissue material properties from computed tomographic images. Our first objective was to define and compare in vivo precision errors for three high-resolution peripheral quantitative computed tomography (HR-pQCT, XtremeCT; Scanco) based FE models of the distal radius and tibia in postmenopausal women...
2016: BMC Musculoskeletal Disorders
Learnmore Mwadzingeni, Hussein Shimelis, Samson Tesfay, Toi J Tsilo
Drought stress is one of the leading constraints to wheat (Triticum aestivum L.) production globally. Breeding for drought tolerance using novel genetic resources is an important mitigation strategy. This study aimed to determine the level of drought tolerance among diverse bread wheat genotypes using agronomic traits and proline analyses and to establish correlation of proline content and agronomic traits under drought-stress conditions in order to select promising wheat lines for breeding. Ninety-six diverse genotypes including 88 lines from the International Maize and Wheat Improvement Center (CIMMYT)'s heat and drought nurseries, and eight local checks were evaluated under greenhouse and field conditions during 2014/15 and 2015/16 making four testing environments...
2016: Frontiers in Plant Science
Meghan C L Howey, Franklin B Sullivan, Jason Tallant, Robert Vande Kopple, Michael W Palace
Forested settings present challenges for understanding the full extent of past human landscape modifications. Field-based archaeological reconnaissance in forests is low-efficiency and most remote sensing techniques are of limited utility, and together, this means many past sites and features in forests are unknown. Archaeologists have increasingly used light detection and ranging (lidar), a remote sensing tool that uses pulses of light to measure reflecting surfaces at high spatial resolution, to address these limitations...
2016: PloS One
Willemijn L Eppenga, Cornelis Kramers, Hieronymus J Derijks, Michel Wensing, Jack F M Wetzels, Peter A G M De Smet
PURPOSE: The use of estimated glomerular filtration rate (eGFR) in daily clinical practice. METHODS: eGFR is a key component in drug therapy management (DTM) in patients with renal impairment. eGFR is routinely reported by laboratories whenever a serum creatinine testing is ordered. In this paper, we will discuss how to use eGFR knowing the limitations of serum creatinine-based formulas. RESULTS: Before starting a renally excreted drug, an equally effective drug which can be used more safely in patients with renal impairment should be considered...
August 27, 2016: European Journal of Clinical Pharmacology
Han Yong Bae, Mun Jong Kim, Jae Hun Sim, Choong Eui Song
In this study, dithiomalonates (DTMs) were demonstrated to be exceptionally efficient Mannich donors in terms of reactivity and stereoselectivity in cinchona-based-squaramide-catalyzed enantioselective Mannich reactions of diverse imines or α-amidosulfones as imine surrogates. Owing to the superior reactivity of DTMs as compared to conventional malonates, the catalyst loading could be reduced to 0.1 mol % without the erosion of enantioselectivity (up to 99 % ee). Furthermore, by the use of a DTM, even some highly challenging primary alkyl α-amidosulfones were smoothly converted into the desired adducts with excellent enantioselectivity (up to 97 % ee), whereas the use of a malonate or monothiomalonate resulted in no reaction under identical conditions...
August 26, 2016: Angewandte Chemie
Annika Sköld, Gunnel Kristina Janeslätt
BACKGROUND: Impaired ability to manage time has been shown in several diagnoses common in childhood. Impaired ability involves activities and participation domain (daily time management, DTM) and body function and structure domain (time-processing ability, TPA). DTM needs to be evaluated from an individual's own perspective. To date, there has been a lack of self-rating instruments for children that focus on DTM. AIM: The aim of this study is to describe psychometric properties of Time-S when used in children aged 10-17 years with a diagnosis of ADHD, Autism, CP or mild ID...
July 8, 2016: Scandinavian Journal of Occupational Therapy
W De Caro, L Mitello, A R Marucci, L Lancia, J Sansoni
Every day there is a data explosion on the web. In 2013, 5 exabytes of content were created each day. Every hour internet networks carries a quantity of texts equivalent to twenty billion books. For idea Iit is a huge mass of information on the linguistic behavior of people and society that was unthinkable until a few years ago. It is an opportunity for valuable analysis for understanding social phenomena, also in nursing and health care sector.This poster shows the the steps of an idealy strategy for textual statistical analysis and the process of extracting useful information about health care, referring expecially nursing care from journal and web information...
2016: Studies in Health Technology and Informatics
Lynne Feehan, Trevor Fraser
UNLABELLED: This case describes an early controlled mobilization (ECM) approach that uses dart-throwing motion (DTM) with a twist orthoses as an alternative to immobilization for conservative management of a minimally displaced and intra-articular distal radius styloid fracture with an associated scapholunate ligament injury in a 47-year-old female health care administrator (JP). Pain-free active DTM began at day 10 (5 times/d) with a dynamic DTM with a twist orthosis worn during the day from weeks 3 to 6...
April 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
Ronnie Kaufmann, Shlomo E Blum, Daniel Elad, Gila Zur
BACKGROUND: Point-of-care Dermatophyte Test Medium (PoC-DTM) is a diagnostic procedure to rule in/rule out dermatophytosis in veterinary clinics. OBJECTIVE: To evaluate the performance of PoC-DTM in the clinic compared to DTM plate culture in a mycology laboratory and to compare results obtained by general practitioners and referral clinicians. ANIMALS: Hair samples were collected from 47 cats and 54 dogs with suspected dermatophytosis and from nine healthy controls (seven cats and two dogs)...
August 2016: Veterinary Dermatology
José Crossa, Diego Jarquín, Jorge Franco, Paulino Pérez-Rodríguez, Juan Burgueño, Carolina Saint-Pierre, Prashant Vikram, Carolina Sansaloni, Cesar Petroli, Deniz Akdemir, Clay Sneller, Matthew Reynolds, Maria Tattaris, Thomas Payne, Carlos Guzman, Roberto J Peña, Peter Wenzl, Sukhwinder Singh
This study examines genomic prediction within 8416 Mexican landrace accessions and 2403 Iranian landrace accessions stored in gene banks. The Mexican and Iranian collections were evaluated in separate field trials, including an optimum environment for several traits, and in two separate environments (drought, D and heat, H) for the highly heritable traits, days to heading (DTH), and days to maturity (DTM). Analyses accounting and not accounting for population structure were performed. Genomic prediction models include genotype × environment interaction (G × E)...
2016: G3: Genes—Genomes—Genetics
Govindan Velu, Jose Crossa, Ravi P Singh, Yuanfeng Hao, Susanne Dreisigacker, Paulino Perez-Rodriguez, Arun K Joshi, Ravish Chatrath, Vikas Gupta, Arun Balasubramaniam, Chhavi Tiwari, Vinod K Mishra, Virinder Singh Sohu, Gurvinder Singh Mavi
Predictability estimated through cross-validation approach showed moderate to high level; hence, genomic selection approach holds great potential for biofortification breeding to enhance grain zinc and iron concentrations in wheat. Wheat (Triticum aestivum L.) is a major staple crop, providing 20 % of dietary energy and protein consumption worldwide. It is an important source of mineral micronutrients such as zinc (Zn) and iron (Fe) for resource poor consumers. Genomic selection (GS) approaches have great potential to accelerate development of Fe- and Zn-enriched wheat...
August 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Hamish Anderson, Greg Hoy
STUDY DESIGN: Case series. INTRODUCTION: This paper describes conservative guidelines for the management of scapho-lunate interosseous ligament (SLIL) injury including fabrication of an orthosis that restricts active wrist movement to the dart-throwers (DTM) plane. PURPOSE OF THE STUDY: The dart throwers' orthosis (DTO) was designed as a response to biomechanical studies suggesting that restraining motion to the DTM would off-load a deficient SLIL...
April 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
Mathew P Robin, Shani A M Osborne, Zoe Pikramenou, Jeffery E Raymond, Rachel K O'Reilly
Block copolymer micelles have been prepared with a dithiomaleimide (DTM) fluorophore located in either the core or shell. Poly(triethylene glycol acrylate)-b-poly(tert-butyl acrylate) (P(TEGA)-b-P(tBA)) was synthesized by RAFT polymerization, with a DTM-functional acrylate monomer copolymerized into either the core forming P(tBA) block or the shell forming P(TEGA) block. Self-assembly by direct dissolution afforded spherical micelles with R h of ca. 35 nm. Core-labeled micelles (CLMs) displayed bright emission (Φf = 17%) due to good protection of the fluorophore, whereas shell-labeled micelles (SLMs) had lower efficiency emission due to collisional quenching in the solvated corona...
January 26, 2016: Macromolecules
Zoltan Bardosi, Wolfgang Freysinger
PURPOSE: The fiducial localization error distribution (FLE) and fiducial configuration govern the application accuracy of point-based registration and drive target registration error (TRE) prediction models. The error of physically localizing patient fiducials ([Formula: see text]) is negligible when a registration probe matches the implanted screws with mechanical precision. Reliable trackers provide an unbiased estimate of the positional error ([Formula: see text]) with cheap repetitions...
June 2016: International Journal of Computer Assisted Radiology and Surgery
Catherine Klersy, Giuseppe Boriani, Annalisa De Silvestri, Georges H Mairesse, Frieder Braunschweig, Valeria Scotti, Anna Balduini, Martin R Cowie, Francisco Leyva
AIMS: Implantable device telemonitoring (DTM) is a diagnostic adjunct to traditional face-to-face hospital visits. Remote device follow-up and earlier diagnoses facilitated by DTM should reduce healthcare utilization. We explored whether DTM reduces healthcare utilization over standard of care (SoC), without compromising patient outcomes. METHODS AND RESULTS: This systematic review and meta-analysis of 11 randomized controlled trials on DTM in patients with heart failure consisted of 5702 patients, with a median of 117 [interquartile range (IQR) 76-331] patients per study [age 65 years (IQR 63-67)] and follow-up range of 12-36 months...
February 2016: European Journal of Heart Failure
Virpi Junttila, Basanta Gautam, Bhaskar Singh Karky, Almasi Maguya, Katri Tegel, Tuomo Kauranne, Katja Gunia, Jarno Hämäläinen, Petri Latva-Käyrä, Ekaterina Nikolaeva, Jussi Peuhkurinen
BACKGROUND: Participatory forest monitoring has been promoted as a means to engage local forest-dependent communities in concrete climate mitigation activities as it brings a sense of ownership to the communities and hence increases the likelihood of success of forest preservation measures. However, sceptics of this approach argue that local community forest members will not easily attain the level of technical proficiency that accurate monitoring needs. Thus it is interesting to establish if local communities can attain such a level of technical proficiency...
December 2015: Carbon Balance and Management
Brahim Benhammouda
The solution of higher-index Hessenberg differential-algebraic equations (DAEs) is of great importance since this type of DAEs often arises in applications. Higher-index DAEs are known to be numerically and analytically difficult to solve. In this paper, we present a new analytical method for the solution of two classes of higher-index Hessenberg DAEs. The method is based on Adomian polynomials and the differential transform method (DTM). First, the DTM is applied to the DAE where the differential transforms of nonlinear terms are calculated using Adomian polynomials...
2015: SpringerPlus
Hiroyuki Watanabe, Masahiro Ono, Hideo Saji
In vivo fluorescence imaging of β-amyloid (Aβ) plaques in the brain is expected to be used as a new method for detecting Alzheimer's disease (AD). We synthesized novel push-pull dimethylaminothiophenyl (DTM) derivatives and evaluated their utility as in vivo fluorescence imaging probes targeting Aβ plaques. As a result, we found that DTM-2 is a promising fluorescent probe for Aβ plaques in the AD brains.
December 14, 2015: Chemical Communications: Chem Comm
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