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https://www.readbyqxmd.com/read/29146510/relative-contributions-of-the-midcarpal-and-radiocarpal-joints-to-dart-thrower-s-motion-at-the-wrist
#1
Patrick M Kane, Bryan G Vopat, P Kaveh Mansuripur, Michael P Gaspar, Scott W Wolfe, Joseph J Crisco, Christopher Got
PURPOSE: To identify the relative contributions of the radiocarpal (RC) and midcarpal (MC) joints to dart-thrower's motion (DTM) of the wrist. METHODS: Six cadaveric upper extremities were fixed to a custom-designed loading jig allowing for pure moment-rotation analysis in 24 different directions of wrist motion. Each specimen was tested in 3 states: intact, simulated radiocarpal fusion (sRCF) and simulated pancarpal fusion (sPCF). Moments of ± 1.5 Nm were applied at each of 24 directions for each state and the resulting wrist rotation recorded...
November 14, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28956183/effectiveness-of-time-related-interventions-in-children-with-adhd-aged-9-15%C3%A2-years-a-randomized-controlled-study
#2
Birgitta Wennberg, Gunnel Janeslätt, Anette Kjellberg, Per A Gustafsson
Specific problems with time and timing that affect daily routines, homework, school work, and social relations have been recognized in children with ADHD. The primary treatments for children with ADHD do not specifically focus on time-related difficulties. The aim of this randomized controlled study (RCT) was to investigate how multimodal interventions, consisting of training in time-processing ability (TPA) and compensation with time-assistive devices (TAD), affect TPA and daily time management (DTM) in children with ADHD and time difficulties, compared with only educational intervention...
September 27, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28919923/revealing-topics-and-their-evolution-in-biomedical-literature-using-bio-dtm-a-case-study-of-ginseng
#3
Qian Chen, Ni Ai, Jie Liao, Xin Shao, Yufeng Liu, Xiaohui Fan
BACKGROUND: Valuable scientific results on biomedicine are very rich, but they are widely scattered in the literature. Topic modeling enables researchers to discover themes from an unstructured collection of documents without any prior annotations or labels. In this paper, taking ginseng as an example, biological dynamic topic model (Bio-DTM) was proposed to conduct a retrospective study and interpret the temporal evolution of the research of ginseng. METHODS: The system of Bio-DTM mainly includes four components, documents pre-processing, bio-dictionary construction, dynamic topic models, topics analysis and visualization...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28858057/effects-of-six-weeks-sprint-strength-and-agility-training-on-body-composition-cardiovascular-and-physiological-parameters-of-male-field-hockey-players
#4
Hanjabam Barun Sharma, Jyotsna Kailashiya
Optimal physiological and cardiovascular characteristics are essential for optimal physical performance. Different types of training regimes affect these characteristics and lead to trainee's adaptation and changes in relevant parameters. In present interventional study we have evaluated effects of six weeks sprint-strength & agility training on such parameters. Twenty four young Indian national hockey players volunteered for this study. BW(weight), BMI, BF (%body fat), LBM (lean body mass), rHR (resting heart rate), rBP (blood pressure), rDP (double-product), P/power (using Running-based Anaerobic Sprint Test), VJ (vertical jump), SP (seated shot-put test), BS (ball-hitting speed), Tm (505-agility test) & VO2max were measured, and changes (d) after specified training regime were studied...
August 26, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28845185/comparison-of-deep-tissue-massage-and-therapeutic-massage-for-lower-back-pain-disease-activity-and-functional-capacity-of-ankylosing-spondylitis-patients-a-randomized-clinical-pilot-study
#5
Mateusz Wojciech Romanowski, Maja Špiritović, Radosław Rutkowski, Adrian Dudek, Włodzimierz Samborski, Anna Straburzyńska-Lupa
OBJECTIVES: This study aims to compare the effectiveness of deep tissue massage (DTM) and therapeutic massage (TM) in the management of ankylosing spondylitis (AS) patients. MATERIALS AND METHODS: This was a small, randomized clinical pilot study. Subjects were 27 men with diagnosed AS, randomly assigned to DTM group or TM group. Subjects in each group had 10 sessions of massage. Outcomes included the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), Modified Schober Test, Finger to Floor Test, chest expansion, and pain intensity of lower back...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28837840/development-of-a-recombinant-yellow-fever-vector-expressing-a-hiv-clade-c-founder-envelope-gp120
#6
Jae-Sung Yu, Hua-Xin Liao, Jamie Pritchett, Cindy Bowman, Callie Vivian, Robert Parks, Shi-Mao Xia, Melissa Cooper, Wilton B Williams, Mattia Bonsignori, Steven G Reed, Meng Chen, Nathan Vandergrift, Charles M Rice, Barton F Haynes
Development of a HIV-1 vaccine is a major global priority. The yellow fever virus (YFV) attenuated vaccine 17D is among the most effective of currently used vaccines. However, the stability of the YFV17D vector when carrying non-flavivirus genes has been problematic. We have constructed and expressed HIV-1 Env in YFV17D with either single transmembrane (STM) or double transmembrane (DTM) YFV E protein domains for the development of anti-HIV antibodies. Here we describe modifications of the YFV17D vector such that HIV-1 Env gp120 is expressed in up to 5 passages in Vero cells...
November 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28816303/reversible-surface-functionalisation-of-emulsion-templated-porous-polymers-using-dithiophenol-maleimide-functional-macromolecules
#7
A M Eissa, P Wilson, C Chen, J Collins, M Walker, D M Haddleton, N R Cameron
A new facile and efficient route for the chemical functionalisation of thiol-acrylate polyHIPE materials with responsive macromolecules using the highly emissive dithiomaleimide (DTM) linker is demonstrated. Functionalisation is found to be reversible upon addition of a thiol-containing compound, glutathione, resulting in switchable surface properties including fluorescence and wettability, hence broadening the scope of applications.
August 29, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28815102/clinical-trials-gov-a-topical-analyses
#8
Vibha Anand, Amos Cahan, Soumya Ghosh
ClinicalTrials.gov was established as a web-based registry for clinical trials of human participants in 2000. Mandatory registration started in 2008. Given more than a decade of registered trials, it's important to understand the "topic" areas and their evolution over time from this resource. This information may help in identifying current knowledge gaps. We use dynamic topic model (DTM) methods to discover topics and their evolution over last 17 years. Our model suggests that there are disease or organ specific trials such as 'Cardiovascular disorders', Heart & Brain conditions', or 'Breast & Prostate cancer' as well as trials registered for general health...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28765278/the-peroxisomal-matrix-protein-translocon-is-a-large-cavity-forming-protein-assembly-into-which-pex5-protein-enters-to-release-its-cargo
#9
Ana F Dias, Tony A Rodrigues, Ana G Pedrosa, Aurora Barros-Barbosa, Tânia Francisco, Jorge E Azevedo
A remarkable property of the machinery for import of peroxisomal matrix proteins is that it can accept already folded proteins as substrates. This import involves binding of newly synthesized proteins by cytosolic peroxisomal biogenesis factor 5 (PEX5) followed by insertion of the PEX5-cargo complex into the peroxisomal membrane at the docking/translocation module (DTM). However, how these processes occur remains largely unknown. Here, we used truncated PEX5 molecules to probe the DTM architecture. We found that the DTM can accommodate a larger number of truncated PEX5 molecules comprising amino acid residues 1-197 than full-length PEX5 molecules...
September 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28756304/chemomechanically-engineered-3d-organotypic-platforms-of-bladder-cancer-dormancy-and-reactivation
#10
Taraka Sai Pavan Grandhi, Thrimoorthy Potta, Rajeshwar Nitiyanandan, Indrani Deshpande, Kaushal Rege
Tumors undergo periods of dormancy followed by reactivation leading to metastatic disease. Arrest in the G0/G1 phase of the cell cycle and resistance to chemotherapeutic drugs are key hallmarks of dormant tumor cells. Here, we describe a 3D platform of bladder cancer cell dormancy and reactivation facilitated by a novel aminoglycoside-derived hydrogel, Amikagel. These 3D dormant tumor microenvironments (3D-DTMs) were arrested in the G0/G1 phase and were highly resistant to anti-proliferative drugs. Inhibition of targets in the cellular protein production machinery led to induction of endoplasmic reticulum (ER) stress and complete ablation of 3D-DTMs...
October 2017: Biomaterials
https://www.readbyqxmd.com/read/28653835/di-1h-tetrazol-5-yl-methane-as-neutral-ligand-in-energetic-transition-metal-complexes
#11
Manuel Freis, Thomas M Klapötke, Jörg Stierstorfer, Norbert Szimhardt
The synthesis of di(1H-tetrazol-5-yl)methane (1, 5-DTM), starting from commercially available sodium azide and malononitrile, is described. This tetrazole was characterized and investigated for use as a neutral nitrogen-rich ligand in various energetic transition metal complexes: ([CuCl2(5-DTM)2]·2H2O (2), [Co(H2O)2(5-DTM)2]Cl2 (3), [Ni(H2O)2(5-DTM)2]Cl2 (4), [Co(H2O)2(5-DTM)2](NO3)2 (6), [Ni(H2O)2(5-DTM)2](NO3)2 (7), [Zn(H2O)2(5-DTM)2](NO3)2 (8), {[Cu3(SO4)2(5-DTM-H)2(H2O)4(5-DTM)2]·2H2O}∞ (9), [Cu(H2O)2(5-DTM)2](NO3)2 (11), [Cu(NO3)2(5-DTM)2]·2H2O (12), [Cu(NO3)2(5-DTM)2] (13), [Cu(H2O)2(5-DTM)2](ClO4)2 (14), and [Cu(ClO4)2(5-DTM)2] (15)...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28588164/diagnosis-of-dermatophytosis-by-conventional-methods-and-comparatative-analysis-of-sabouraud-dextrose-agar-and-dermatophyte-test-medium-for-isolation-of-dermatophytes
#12
S Monwar, M A Hossain, F Boby, H Begum, N Begum
Dermatophytosis is a fungal disease which ranked as one of the most common cutaneous condition in all over the world. The aim of this cross sectional observational study is to identify the etiological agent of dermatophytosis and comparison of Sabouraud dextrose agar (SDA) and Dermatophyte test medium (DTM) for the primary isolation of dermatophytes among the clinically suspected cases of dermatophytosis from the outpatient Department of Dermatology and Venereology, Mymensingh Medical College Hospital from July 2013 to December 2015...
April 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28546133/tissue-engineered-trachea-regeneration-using-decellularized-trachea-matrix-treated-with-laser-micropore-technique
#13
Yong Xu, Dan Li, Zongqi Yin, Aijuan He, Miaomiao Lin, Gening Jiang, Xiao Song, Xuefei Hu, Yi Liu, Jinpeng Wang, Xiaoyun Wang, Liang Duan, Guangdong Zhou
Tissue-engineered trachea provides a promising approach for reconstruction of long segmental tracheal defects. However, a lack of ideal biodegradable scaffolds greatly restricts its clinical translation. Decellularized trachea matrix (DTM) is considered a proper scaffold for trachea cartilage regeneration owing to natural tubular structure, cartilage matrix components, and biodegradability. However, cell residual and low porosity of DTM easily result in immunogenicity and incomplete cartilage regeneration. To address these problems, a laser micropore technique (LMT) was applied in the current study to modify trachea sample porosity to facilitate decellular treatment and cell ingrowth...
May 22, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28456952/preparation-of-scaffolds-from-decellularized-testicular-matrix
#14
Yoni Baert, Ellen Goossens
Biological scaffolds composed of extracellular matrix (ECM) are typically derived by processes that involve decellularization of tissues or organs. Here we describe a simple and robust methodology for the preparation of decellularized testicular matrix (DTM) scaffolds with minimal damage to the native three-dimensional structure and tissue-specific ECM components. Such DTM scaffolds can help to gain a better insight into the molecular composition and function of testicular ECM and to develop new tissue engineering approaches to treat various types of male fertility disorders...
April 30, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28379609/rna-guided-cas9-as-an-in%C3%A2-vivo-desired-target-mutator-in-maize
#15
Chuxi Li, Changlin Liu, Xiantao Qi, Yongchun Wu, Xiaohong Fei, Long Mao, Beijiu Cheng, Xinhai Li, Chuanxiao Xie
The RNA-guided Cas9 system is a versatile tool for genome editing. Here, we established a RNA-guided endonuclease (RGEN) system as an in vivo desired-target mutator (DTM) in maize to reduce the linkage drag during breeding procedure, using the LIGULELESS1 (LG1) locus as a proof-of-concept. Our system showed 51.5%-91.2% mutation frequency in T0 transgenic plants. We then crossed the T1 plants stably expressing DTM with six diverse recipient maize lines and found that 11.79%-28.71% of the plants tested were mutants induced by the DTM effect...
April 5, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28253317/development-of-the-diabetes-typology-model-for-discerning-type-2-diabetes-mellitus-with-national-survey-data
#16
Anna Bellatorre, Sharon H Jackson, Kelvin Choi
OBJECTIVE: To classify individuals with diabetes mellitus (DM) into DM subtypes using population-based studies. DESIGN: Population-based survey. SETTING: Individuals participated in 2003-2004, 2005-2006, or 2009-2010 the National Health and Nutrition Examination Survey (NHANES), and 2010 Coronary Artery Risk Development in Young Adults (CARDIA) survey (research materials obtained from the National Heart, Lung, and Blood Institute Biologic Specimen and Data Repository Information Coordinating Center)...
2017: PloS One
https://www.readbyqxmd.com/read/28098810/state-of-the-art-dtm-generation-using-airborne-lidar-data
#17
REVIEW
Ziyue Chen, Bingbo Gao, Bernard Devereux
Digital terrain model (DTM) generation is the fundamental application of airborne Lidar data. In past decades, a large body of studies has been conducted to present and experiment a variety of DTM generation methods. Although great progress has been made, DTM generation, especially DTM generation in specific terrain situations, remains challenging. This research introduces the general principles of DTM generation and reviews diverse mainstream DTM generation methods. In accordance with the filtering strategy, these methods are classified into six categories: surface-based adjustment; morphology-based filtering, triangulated irregular network (TIN)-based refinement, segmentation and classification, statistical analysis and multi-scale comparison...
January 14, 2017: Sensors
https://www.readbyqxmd.com/read/28035277/a-model-of-the-extent-and-distribution-of-woody-linear-features-in-rural-great-britain
#18
Paul Scholefield, Dan Morton, Clare Rowland, Peter Henrys, David Howard, Lisa Norton
Hedges and lines of trees (woody linear features) are important boundaries that connect and enclose habitats, buffer the effects of land management, and enhance biodiversity in increasingly impoverished landscapes. Despite their acknowledged importance in the wider countryside, they are usually not considered in models of landscape function due to their linear nature and the difficulties of acquiring relevant data about their character, extent, and location. We present a model which uses national datasets to describe the distribution of woody linear features along boundaries in Great Britain...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27975450/molecular-networking-approach-to-detect-new-analogues-of-prenylated-stilbenes-from-macaranga-spp
#19
T Péresse, P M Allard, J L Wolfender, V C Pham, Dtm Huong, F Roussi, M Litaudon
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27862429/c-terminal-modification-and-multimerization-increase-the-efficacy-of-a-proline-rich-antimicrobial-peptide
#20
Wenyi Li, Neil M O'Brien-Simpson, Shenggen Yao, Julien Tailhades, Eric C Reynolds, Raymond M Dawson, Laszlo Otvos, Mohammed Akhter Hossain, Frances Separovic, John D Wade
Two series of branched tetramers of the proline-rich antimicrobial peptide (PrAMP), Chex1-Arg20, were prepared to improve antibacterial selectivity and potency against a panel of Gram-negative nosocomial pathogens including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. First, tetramerization was achieved by dithiomaleimide (DTM) conjugation of two C-terminal-cysteine bearing dimers that also incorporated C-terminal peptide chemical modification. DTM-linked tetrameric peptides containing a C-terminal hydrazide moiety on each dimer exhibited highly potent activities in the minimum inhibitory concentration (MIC) range of 0...
January 5, 2017: Chemistry: a European Journal
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