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https://www.readbyqxmd.com/read/28456952/preparation-of-scaffolds-from-decellularized-testicular-matrix
#1
Yoni Baert, Ellen Goossens
Biological scaffolds composed of extracellular matrix (ECM) are typically derived by processes that involve decellularization of tissues or organs. Here we describe a simple and robust methodology for the preparation of decellularized testicular matrix (DTM) scaffolds with minimal damage to the native three-dimensional structure and tissue-specific ECM components. Such DTM scaffolds can help to gain a better insight into the molecular composition and function of testicular ECM and to develop new tissue engineering approaches to treat various types of male fertility disorders...
April 30, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28379609/rna-guided-cas9-as-an-in-vivo-desired-target-mutator-in-maize
#2
Chuxi Li, Changlin Liu, Xiantao Qi, Yongchun Wu, Xiaohong Fei, Long Mao, Beijiu Chen, Xinhai Li, Chuanxiao Xie
The RNA-guided Cas9 system is a versatile tool for genome editing. Here, we established a RNA-guided endonuclease (RGEN) system as an in vivo desired-target mutator (DTM) in maize to reduce the linkage drag during breeding procedure, using the LIGULELESS1 (LG1) locus as a proof-of-concept. Our system showed 51.5% to 91.2% mutation frequency in T0 transgenic plants. We then crossed the T1 plants stably expressing DTM with six diverse recipient maize lines and found that 11.79% to 28.71% of the plants tested were mutants induced by the DTM effect...
April 5, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28253317/development-of-the-diabetes-typology-model-for-discerning-type-2-diabetes-mellitus-with-national-survey-data
#3
Anna Bellatorre, Sharon H Jackson, Kelvin Choi
OBJECTIVE: To classify individuals with diabetes mellitus (DM) into DM subtypes using population-based studies. DESIGN: Population-based survey. SETTING: Individuals participated in 2003-2004, 2005-2006, or 2009-2010 the National Health and Nutrition Examination Survey (NHANES), and 2010 Coronary Artery Risk Development in Young Adults (CARDIA) survey (research materials obtained from the National Heart, Lung, and Blood Institute Biologic Specimen and Data Repository Information Coordinating Center)...
2017: PloS One
https://www.readbyqxmd.com/read/28098810/state-of-the-art-dtm-generation-using-airborne-lidar-data
#4
REVIEW
Ziyue Chen, Bingbo Gao, Bernard Devereux
Digital terrain model (DTM) generation is the fundamental application of airborne Lidar data. In past decades, a large body of studies has been conducted to present and experiment a variety of DTM generation methods. Although great progress has been made, DTM generation, especially DTM generation in specific terrain situations, remains challenging. This research introduces the general principles of DTM generation and reviews diverse mainstream DTM generation methods. In accordance with the filtering strategy, these methods are classified into six categories: surface-based adjustment; morphology-based filtering, triangulated irregular network (TIN)-based refinement, segmentation and classification, statistical analysis and multi-scale comparison...
January 14, 2017: Sensors
https://www.readbyqxmd.com/read/28035277/a-model-of-the-extent-and-distribution-of-woody-linear-features-in-rural-great-britain
#5
Paul Scholefield, Dan Morton, Clare Rowland, Peter Henrys, David Howard, Lisa Norton
Hedges and lines of trees (woody linear features) are important boundaries that connect and enclose habitats, buffer the effects of land management, and enhance biodiversity in increasingly impoverished landscapes. Despite their acknowledged importance in the wider countryside, they are usually not considered in models of landscape function due to their linear nature and the difficulties of acquiring relevant data about their character, extent, and location. We present a model which uses national datasets to describe the distribution of woody linear features along boundaries in Great Britain...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27975450/molecular-networking-approach-to-detect-new-analogues-of-prenylated-stilbenes-from-macaranga-spp
#6
T Péresse, P M Allard, J L Wolfender, V C Pham, Dtm Huong, F Roussi, M Litaudon
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27862429/c-terminal-modification-and-multimerization-increase-the-efficacy-of-a-proline-rich-antimicrobial-peptide
#7
Wenyi Li, Neil M O'Brien-Simpson, Shenggen Yao, Julien Tailhades, Eric C Reynolds, Raymond M Dawson, Laszlo Otvos, Mohammed Akhter Hossain, Frances Separovic, John D Wade
Two series of branched tetramers of the proline-rich antimicrobial peptide (PrAMP), Chex1-Arg20, were prepared to improve antibacterial selectivity and potency against a panel of Gram-negative nosocomial pathogens including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. First, tetramerization was achieved by dithiomaleimide (DTM) conjugation of two C-terminal-cysteine bearing dimers that also incorporated C-terminal peptide chemical modification. DTM-linked tetrameric peptides containing a C-terminal hydrazide moiety on each dimer exhibited highly potent activities in the minimum inhibitory concentration (MIC) range of 0...
November 16, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27830091/new-indices-of-endothelial-function-measured-by-digital-thermal-monitoring-of-vascular-reactivity-data-from-6084-patients-registry
#8
Morteza Naghavi, Albert A Yen, Alex W H Lin, Hirofumi Tanaka, Stanley Kleis
Background. Endothelial function is viewed as a barometer of cardiovascular health and plays a central role in vascular reactivity. Several studies showed digital thermal monitoring (DTM) as a simple noninvasive method to measure vascular reactivity that is correlated with atherosclerosis risk factors and coronary artery disease. Objectives. To further evaluate the relations between patient characteristics and DTM indices in a large patient registry. Methods. DTM measures were correlated with age, sex, heart rate, and systolic and diastolic blood pressure in 6084 patients from 18 clinics...
2016: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/27828567/factors-associated-with-negative-self-perception-of-oral-health-among-institutionalized-elderly
#9
Laércio Almeida de Melo, Meily de Mello Sousa, Annie Karoline Bezerra de Medeiros, Adriana da Fonte Porto Carreiro, Kenio Costa de Lima
The aim of this study was to determine self-perception of oral-health in institutionalized elderly, and look into the sociodemographic and clinical aspects associated with negative self-perception. One hundred and sixty-six elderly were assessed by answering a self-perception question that predicts the GOHAI (Geriatric Oral Health Assessment Index). Sociodemographic data was obtained from a previously validated questionnaire and clinical data taken from the WHO file and QST-TMD used to check the existence of TMD (temporomandibular disturbance)...
November 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27815243/bmp4-acts-as-a-dorsal-telencephalic-morphogen-in-a-mouse-embryonic-stem-cell-culture-system
#10
Momoko Watanabe, Ernest S Fung, Felicia B Chan, Jessica S Wong, Margaret Coutts, Edwin S Monuki
The concept of a morphogen - a molecule that specifies two or more cell fates in a concentration-dependent manner - is paradigmatic in developmental biology. Much remains unknown, however, about the existence of morphogens in the developing vertebrate central nervous system (CNS), including the mouse dorsal telencephalic midline (DTM). Bone morphogenetic proteins (BMPs) are candidate DTM morphogens, and our previous work demonstrated BMP4 sufficiency to induce one DTM cell fate - that of choroid plexus epithelial cells (CPECs) - in a mouse embryonic stem cell (mESC) culture system...
December 15, 2016: Biology Open
https://www.readbyqxmd.com/read/27785895/transcriptome-analysis-of-zebrafish-embryos-exposed-to-deltamethrin
#11
Tsung-Cheng Chueh, Li-Sung Hsu, Chin-Ming Kao, Tung-Wei Hsu, Hung-Yu Liao, Kuan-Yi Wang, Ssu Ching Chen
Deltamethrin (DTM), a type II pyrethroid, is one of the most commonly used insecticides. The increased use of pyrethroid leads to potential adverse effects, particularly in sensitive populations such as children and pregnant women. None of the related studies was focused on the transcriptome responses in zebrafish embryos after treatment with DTM; therefore, RNA-seq, a high-throughput method, was performed to analyze the global expression of differential expressed genes (DEGs) in zebrafish embryos treated with DTM (40 and 80 μg/L) from fertilization to 48 h postfertilization (hpf) as compared with that in the control group (without DTM treatment)...
May 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/27777859/a-new-multi-step-technique-with-differential-transform-method-for-analytical-solution-of-some-nonlinear-variable-delay-differential-equations
#12
Brahim Benhammouda, Hector Vazquez-Leal
This work presents an analytical solution of some nonlinear delay differential equations (DDEs) with variable delays. Such DDEs are difficult to treat numerically and cannot be solved by existing general purpose codes. A new method of steps combined with the differential transform method (DTM) is proposed as a powerful tool to solve these DDEs. This method reduces the DDEs to ordinary differential equations that are then solved by the DTM. Furthermore, we show that the solutions can be improved by Laplace-Padé resummation method...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27766956/application-of-dynamic-topic-models-to-toxicogenomics-data
#13
Mikyung Lee, Zhichao Liu, Ruili Huang, Weida Tong
BACKGROUND: All biological processes are inherently dynamic. Biological systems evolve transiently or sustainably according to sequential time points after perturbation by environment insults, drugs and chemicals. Investigating the temporal behavior of molecular events has been an important subject to understand the underlying mechanisms governing the biological system in response to, such as, drug treatment. The intrinsic complexity of time series data requires appropriate computational algorithms for data interpretation...
October 6, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27670688/simultaneous-proteomic-discovery-and-targeted-monitoring-using-liquid-chromatography-ion-mobility-spectrometry-and-mass-spectrometry
#14
Kristin E Burnum-Johnson, Song Nie, Cameron P Casey, Matthew E Monroe, Daniel J Orton, Yehia M Ibrahim, Marina A Gritsenko, Therese R W Clauss, Anil K Shukla, Ronald J Moore, Samuel O Purvine, Tujin Shi, Weijun Qian, Tao Liu, Erin S Baker, Richard D Smith
Current proteomic approaches include both broad discovery measurements and quantitative targeted analyses. In many cases, discovery measurements are initially used to identify potentially important proteins (e.g. candidate biomarkers) and then targeted studies are employed to quantify a limited number of selected proteins. Both approaches, however, suffer from limitations. Discovery measurements aim to sample the whole proteome but have lower sensitivity, accuracy, and quantitation precision than targeted approaches, whereas targeted measurements are significantly more sensitive but only sample a limited portion of the proteome...
December 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27619649/in-vivo-precision-of-three-hr-pqct-derived-finite-element-models-of-the-distal-radius-and-tibia-in-postmenopausal-women
#15
C E Kawalilak, S A Kontulainen, M A Amini, J L Lanovaz, W P Olszynski, J D Johnston
BACKGROUND: The distal radius is the most common osteoporotic fracture site occurring in postmenopausal women. Finite element (FE) modeling is a non-invasive mathematical technique that can estimate bone strength using inputted geometry/micro-architecture and tissue material properties from computed tomographic images. Our first objective was to define and compare in vivo precision errors for three high-resolution peripheral quantitative computed tomography (HR-pQCT, XtremeCT; Scanco) based FE models of the distal radius and tibia in postmenopausal women...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27610116/screening-of-bread-wheat-genotypes-for-drought-tolerance-using-phenotypic-and-proline-analyses
#16
Learnmore Mwadzingeni, Hussein Shimelis, Samson Tesfay, Toi J Tsilo
Drought stress is one of the leading constraints to wheat (Triticum aestivum L.) production globally. Breeding for drought tolerance using novel genetic resources is an important mitigation strategy. This study aimed to determine the level of drought tolerance among diverse bread wheat genotypes using agronomic traits and proline analyses and to establish correlation of proline content and agronomic traits under drought-stress conditions in order to select promising wheat lines for breeding. Ninety-six diverse genotypes including 88 lines from the International Maize and Wheat Improvement Center (CIMMYT)'s heat and drought nurseries, and eight local checks were evaluated under greenhouse and field conditions during 2014/15 and 2015/16 making four testing environments...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27584031/detecting-precontact-anthropogenic-microtopographic-features-in-a-forested-landscape-with-lidar-a-case-study-from-the-upper-great-lakes-region-ad-1000-1600
#17
Meghan C L Howey, Franklin B Sullivan, Jason Tallant, Robert Vande Kopple, Michael W Palace
Forested settings present challenges for understanding the full extent of past human landscape modifications. Field-based archaeological reconnaissance in forests is low-efficiency and most remote sensing techniques are of limited utility, and together, this means many past sites and features in forests are unknown. Archaeologists have increasingly used light detection and ranging (lidar), a remote sensing tool that uses pulses of light to measure reflecting surfaces at high spatial resolution, to address these limitations...
2016: PloS One
https://www.readbyqxmd.com/read/27568310/drug-therapy-management-in-patients-with-renal-impairment-how-to-use-creatinine-based-formulas-in-clinical-practice
#18
Willemijn L Eppenga, Cornelis Kramers, Hieronymus J Derijks, Michel Wensing, Jack F M Wetzels, Peter A G M De Smet
PURPOSE: The use of estimated glomerular filtration rate (eGFR) in daily clinical practice. METHODS: eGFR is a key component in drug therapy management (DTM) in patients with renal impairment. eGFR is routinely reported by laboratories whenever a serum creatinine testing is ordered. In this paper, we will discuss how to use eGFR knowing the limitations of serum creatinine-based formulas. RESULTS: Before starting a renally excreted drug, an equally effective drug which can be used more safely in patients with renal impairment should be considered...
December 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27486059/direct-catalytic-asymmetric-mannich-reaction-with-dithiomalonates-as-excellent-mannich-donors-organocatalytic-synthesis-of-r-sitagliptin
#19
Han Yong Bae, Mun Jong Kim, Jae Hun Sim, Choong Eui Song
In this study, dithiomalonates (DTMs) were demonstrated to be exceptionally efficient Mannich donors in terms of reactivity and stereoselectivity in cinchona-based-squaramide-catalyzed enantioselective Mannich reactions of diverse imines or α-amidosulfones as imine surrogates. Owing to the superior reactivity of DTMs as compared to conventional malonates, the catalyst loading could be reduced to 0.1 mol % without the erosion of enantioselectivity (up to 99 % ee). Furthermore, by the use of a DTM, even some highly challenging primary alkyl α-amidosulfones were smoothly converted into the desired adducts with excellent enantioselectivity (up to 97 % ee), whereas the use of a malonate or monothiomalonate resulted in no reaction under identical conditions...
August 26, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27387553/self-rating-of-daily-time-management-in-children-psychometric-properties-of-the-time-s
#20
Annika Sköld, Gunnel Kristina Janeslätt
BACKGROUND: Impaired ability to manage time has been shown in several diagnoses common in childhood. Impaired ability involves activities and participation domain (daily time management, DTM) and body function and structure domain (time-processing ability, TPA). DTM needs to be evaluated from an individual's own perspective. To date, there has been a lack of self-rating instruments for children that focus on DTM. AIM: The aim of this study is to describe psychometric properties of Time-S when used in children aged 10-17 years with a diagnosis of ADHD, Autism, CP or mild ID...
May 2017: Scandinavian Journal of Occupational Therapy
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