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https://www.readbyqxmd.com/read/29244117/quality-of-life-self-esteem-and-future-expectations-of-adolescent-and-young-adult-cancer-survivors
#1
Kareen N Tonsing, Rosaleen Ow
Significant advancements in treatment modalities over the past few decades have significantly improved the survival rates of many types of childhood cancer, directing attention to the psychosocial consequences of successful treatment and subsequent survival. This study assesses quality of life (QoL) among survivors of childhood cancer. Data were collected by means of a survey questionnaire. Participants were assured of confidentiality and of the voluntary nature of participation. Participants ranged in age from 12 to 24 years (mean age = 17...
December 13, 2017: Health & Social Work
https://www.readbyqxmd.com/read/29243572/development-dissemination-and-applications-of-a-new-terminological-resource-the-q-code-taxonomy-for-professional-aspects-of-general-practice-family-medicine
#2
Marc Jamoulle, Melissa Resnick, Julien Grosjean, Ashwin Ittoo, Elena Cardillo, Robert Vander Stichele, Stefan Darmoni, Marc Vanmeerbeek
BACKGROUND: While documentation of clinical aspects of General Practice/Family Medicine (GP/FM) is assured by the International Classification of Primary Care (ICPC), there is no taxonomy for the professional aspects (context and management) of GP/FM. OBJECTIVES: To present the development, dissemination, applications, and resulting face validity of the Q-Codes taxonomy specifically designed to describe contextual features of GP/FM, proposed as an extension to the ICPC...
December 15, 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/29242725/68ga-psma-pet-ct-imaging-predicting-intraprostatic-tumor-extent-extracapsular-extension-and-seminal-vesicle-invasion-prior-to-radical-prostatectomy-in-patients-with-prostate-cancer
#3
Christoph-Alexander J von Klot, Axel S Merseburger, Alena Böker, Sebastian Schmuck, Tobias L Ross, Frank M Bengel, Markus A Kuczyk, Christoph Henkenberens, Hans Christiansen, Hans-Jürgen Wester, Wiebke Solass, Marcel Lafos, Thorsten Derlin
Purpose: 68Ga-labeled prostate-specific membrane antigen (PSMA) ligand positron emission tomography/computed tomography (PET/CT) has shown promising results in patients with biochemical recurrence after primary therapy for prostate cancer. In this study, we evaluated the usefulness of PSMA I&T (imaging and therapy) PET/CT prior to radical prostatectomy. Methods: The study population consisted of 21 patients with prostate cancer who underwent 68Ga-PSMA I&T PET/CT before either open or laparoscopic radical prostatectomy...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29240413/reversible-twisting-of-primary-amides-via-ground-state-n-c-o-destabilization-highly-twisted-rotationally-inverted-acyclic-amides
#4
Guangrong Meng, Shicheng Shi, Roger A Lalancette, Roman Szostak, Michal Szostak
Since the seminal studies by Pauling in 1930s, planarity has become the defining characteristic of the amide bond. Planarity of amides has central implications for the reactivity and chemical properties of amides of relevance to a range of chemical disciplines. While the vast majority of amides are planar, non-planarity has a profound effect on the properties of the amide bond, with the most common method to restrict the amide bond relying on the incorporation of the amide function into a rigid cyclic ring system...
December 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29239112/male-reproductive-tract-and-spermatozoa-ultrastructure-in-the-grasshopper-orphulella-punctata-de-geer-1773-insecta-orthoptera-caelifera
#5
Daniela Santos Martins Silva, Jamile Fernanda Silva Cossolin, Marcelo Ribeiro Pereira, José Lino-Neto, Carlos Frankl Sperber, José Eduardo Serrão
Identification Orphulellini grasshoppers (Acrididae: Gomphocerinae) species has been difficult due to high polymorphism rate. Orphulella Giglio-Tos, 1894 is a genus with widespread geographical distribution and poor descriptions. Orphulella punctata (De Geer, 1773) has an extensive record of occurrence and available information about the phallic complex, however, there is poor data describing other parts of the male reproductive tract. The objective of this study was characterizes the internal organs of the male reproductive system and spermatozoa of O...
December 14, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29237198/-sociology-as-a-major-factor-for-the-psychiatrie-enquete-in-the-federal-republic-of-germany-results-from-expert-interviews-and-document-analyses
#6
Felicitas Söhner, Heiner Fangerau, Thomas Becker
Objective This paper examines the influence of sociology as a discipline on the Psychiatrie-Enquete by analysing interviews with expert (psychiatrist, psychologist, sociologist etc.) witnesses of the Enquete process and by analysing pertinent documents. Methods 24 interviews were conducted and analysed using qualitative secondary analysis. Results Sociological texts and research results influenced the professional development of psychiatrists at the time. Cross-talk between psychiatry and sociology developed through seminal sociological analyses of psychiatric institutions and the interest taken in medical institutions in a number of sociological texts...
December 13, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/29235909/the-role-of-balint-group-training-in-the-professional-and-personal-development-of-family-medicine-residents
#7
Marty Player, John R Freedy, Vanessa Diaz, Clive Brock, Alexander Chessman, Carolyn Thiedke, Alan Johnson
This paper presents a study based on the participation of PGY2 and PGY3 family medicine residents in Balint seminars that occurred twice monthly for 24 months. Balint groups were cofacilitated by leader pairs experienced with the Balint method. Prior to residency graduation, 18 of 19 eligible resident physicians (94.5%) completed 30- to 60-min semistructured interviews conducted by a research assistant. Resident physicians were told that these individual interviews concerned "…how we teach communication in residency...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29233452/downregulation-of-caspase-8-in-a-group-of-iranian-breast-cancer-patients-a-pilot-study
#8
Masoumeh Aghababazadeh, Najmeh Dorraki, Fahimeh Afzal Javan, Asieh Sadat Fattahi, Masoumeh Gharib, Alireza Pasdar
PURPOSE: It is now well known that evading apoptosis, as a cancer hallmark, can lead to tumour initiation, progression and metastasis. As a result of genome wide association studies, an initiator protease in this pathway, caspase 8 (CASP8), has been found to be an important gene regarding breast cancer susceptibility. The alterations of the expression of this gene have been reported in breast cancer cell lines. Given that in previous studies expression analysis of this gene had only been done in breast cancer cell lines, in this study we aimed to evaluate the expression of this gene in breast cancer tissues versus adjacent normal tissues, using real-time quantitative method...
December 7, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29232249/clinical-trials-in-valvular-surgery-a-2018-update
#9
Bobby Yanagawa, Amine Mazine, Derrick Y Tam, Subodh Verma
PURPOSE OF REVIEW: There is a growing emphasis on the conduct of large-scale, multicenter randomized controlled trials (RCTs) to guide decision-making in cardiac surgery. Here we review recent landmark RCTs in cardiac valvular surgery. RECENT FINDINGS: RCTs are the gold-standard level of data in medicine. However, there are unique challenges of conducting large-scale surgical trials including funding, blinding, generalizability, nonstandardization of the surgical technique, crossover, among others...
December 11, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29230840/correlation-of-biochemical-constituents-of-seminal-plasma-with-semen-quality-in-teddy-goat-capra-hircus-bucks
#10
S Umar, M Ahmad, I Ahmad, M Zubair, Z Umar, A S Qureshi, A Manzoor, A Murtaza, A Shaukat
This study was planned to determine the relationship between semen quality parameters and the levels of biochemical constituents of seminal plasma of Teddy (Capra hircus) buck semen. For this purpose, semen ejaculates were collected from five mature healthy Teddy bucks. All the experimental bucks were kept under natural environmental conditions. Semen was collected twice in a week for the duration of 6 weeks by Artificial Vagina (AV) in the breeding season (February-April). Two successive ejaculates of single buck were pooled at time of collection, and a total of 60 semen samples were processed for semen analysis...
December 12, 2017: Andrologia
https://www.readbyqxmd.com/read/29230439/ex-vivo-detection-and-quantification-of-gold-nanoparticles-in-human-seminal-and-follicular-fluids
#11
Dimitrios Bitounis, Jean-Philippe Klein, Lionel Mery, Amira El-Merhie, Valérie Forest, Delphine Boudard, Jérémie Pourchez, Michèle Cottier
Increasing consumption of engineered nanoparticles and occupational exposure to novel, ultrafine airborne particles during the last decades has coincided with deterioration of sperm parameters and delayed fecundity. In order to prevent possible adverse health effects and ensure a sustainable growth for the nanoparticle industry, the ability to investigate the nanosized, mineralogical load of human reproductive systems is becoming a real clinical need. Toward this goal, the current study proposes two methods for the detection and quantification of engineered nanoparticles in human follicular and seminal fluid, developed with the use of well-defined 60 nm Au particles...
December 12, 2017: Analyst
https://www.readbyqxmd.com/read/29230007/elevated-preoperative-neutrophil-lymphocyte-ratio-predicts-upgrading-at-radical-prostatectomy
#12
Mehmet Özsoy, Marco Moschini, Harun Fajkovic, Francesco Soria, Christian Seitz, Tobias Klatte, Kilian Gust, Alberto Briganti, Pierre I Karakiewicz, Morgan Roupret, Gero Kramer, Shahrokh F Shariat
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) is a widely used, representative marker of systemic inflammatory response within the body. NLR can be calculated from simple, inexpensive peripheral blood samples. High NLR is a negative prognostic factor in a variety of malignancies including urological tumors. In this study, we aim to assess the prognostic value of preoperative neutrophil- lymphocyte ratio (NLR) in patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa)...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29229667/prostate-organogenesis
#13
Jeffrey C Francis, Amanda Swain
The prostate is a male exocrine gland that secretes components of the seminal fluid. In men, prostate tumors are one of the most prevalent cancers. Studies on the development of the prostate have given a better understanding of the processes and genes that are important in the formation of this organ and have provided insights into the mechanisms of prostate tumorigenesis. These developmental studies have provided evidence that some of the genes and signaling pathways involved in development are reactivated or deregulated during prostate cancer...
December 11, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29229299/diffusion-mri-of-white-matter-microstructure-development-in-childhood-and-adolescence-methods-challenges-and-progress
#14
REVIEW
Christian K Tamnes, David R Roalf, Anne-Lise Goddings, Catherine Lebel
Diffusion magnetic resonance imaging (dMRI) continues to grow in popularity as a useful neuroimaging method to study brain development, and longitudinal studies that track the same individuals over time are emerging. Over the last decade, seminal work using dMRI has provided new insights into the development of brain white matter (WM) microstructure, connections and networks throughout childhood and adolescence. This review provides an introduction to dMRI, both diffusion tensor imaging (DTI) and other dMRI models, as well as common acquisition and analysis approaches...
December 7, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29228232/external-validation-of-two-web-based-postoperative-nomograms-predicting-the-probability-of-early-biochemical-recurrence-after-radical-prostatectomy-a-retrospective-cohort-study
#15
Kei Yoneda, Takanobu Utsumi, Takatoshi Somoto, Ken Wakai, Ryo Oka, Takumi Endo, Masashi Yano, Naoto Kamiya, Nobuyuki Hiruta, Hiroyoshi Suzuki
The present study aimed to validate and compare the predictive accuracies of the Memorial Sloan Kettering Cancer Center (MSKCC) and Johns Hopkins University (JHU) web-based postoperative nomograms for predicting early biochemical recurrence (BCR) after radical prostatectomy (RP) and to analyze clinicopathological factors to predict early BCR after RP using our dataset. The c-index was 0.72 (95% confidence (CI): 0.61-0.83) for the MSKCC nomogram and 0.71 (95% CI: 0.61-0.81) for the and JHU nomogram, demonstrating fair performance in the Japanese population...
December 8, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29227444/the-association-between-local-economic-conditions-and-opioid-prescriptions-among-disabled-medicare-beneficiaries
#16
Chao Zhou, Ning Neil Yu, Jan L Losby
BACKGROUND: This paper concerns public health crises today-the problem of opioid prescription access and related abuse. Inspired by Case and Deaton's seminal work on increasing mortality among white Americans with lower education, this paper explores the relationship between opioid prescribing and local economic factors. OBJECTIVE: We examined the association between county-level socioeconomic factors (median household income, unemployment rate, Gini index) and opioid prescribing...
January 2018: Medical Care
https://www.readbyqxmd.com/read/29226989/transcriptome-characterization-of-male-accessory-glands-in-ants-to-identify-molecules-involved-in-their-reproductive-success
#17
A Gotoh, S Shigenobu, K Yamaguchi, S Kobayashi, F Ito, K Tsuji
In insects, seminal fluid proteins that are produced by male accessory glands and transferred to females during mating have key functions in sperm competition and sperm physiology that lead to male reproductive success. In ants, male reproductive success also depends on the longevity of sperm stored in the queen's spermatheca because their sexual offspring are usually produced only after a prolonged storage period. We identified genes that were up-regulated in the male accessory glands relative to the bodies of Crematogaster osakensis to characterize the reproductive molecules associated with male reproductive success in ants...
December 11, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/29226521/the-ontogeny-of-the-female-reproductive-system-in-the-parasitic-castrator-pea-crab-calyptraeotheres-garthi-implications-for-its-mating-system
#18
Emiliano H Ocampo, Tomás A Luppi, Eduardo D Spivak, Sebastian Klaus
The knowledge of the mating system of pea crabs is still fragmentary as it remains dubious whether females copulate in the juvenile and free-living 'hard' or in the obligatory symbiotic stages (adult stage 'V' or intermediate stages II to IV). To discriminate between these two possibilities, we analysed the female seminal receptacles, vagina and opercula, and the sperm content in different stages of the pea crab Calyptraeotheres garthi. Our histology and scanning electron microscopy results revealed that in the hard stage the seminal receptacle is simple without secretory epithelia, and vagina and opercula are not controlled by musculature...
December 11, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29226429/morphological-variations-of-the-human-ejaculatory-ducts-in-relation-to-the-prostatic-urethra
#19
A P Malalasekera, K Sivasuganthan, S Sarangan, K Thaneshan, D N Weerakoon, Y Mathangasinghe, C L Gunasekera, S Mallawaarachchi, N D Nanayakkara, D J Anthony, D Ediriweera
PURPOSE: Loss of ejaculation can follow transurethral resection of the prostate (TURP). Periverumontanal prostate tissue is preserved in ejaculation-preserving TURP (ep-TURP). Knowledge of ejaculatory duct anatomy in relation to the prostatic urethra can help in ep-TURP. This was evaluated in cross-sections of the prostate using a 3D model to determine a safe zone for resecting the prostate in ep-TURP. MATERIALS AND METHODS: A 3D reconstruction of the ejaculatory ducts was developed on the basis of six prostate gland cross-sections...
December 11, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/29226316/interpersonal-predictors-of-stress-generation-is%C3%A2-there-a-super-factor
#20
Josephine H Shih, Matthew G Barstead, Nicole Dianno
Hammen's (1991, Journal of Abnormal Psychology, 100, 555-561) seminal paper on stress generation highlighted the reciprocal relationship between stress and depression. Not only does stress predict depression, but women with a diagnosis of depression also experienced subsequent increased levels of stress. In the ensuing years, depression researchers have moved beyond clinical predictors and examined whether depression vulnerability factors also contribute to stress generation. This interest has led to a growing focus on interpersonal vulnerability factors that contribute to stress generation...
December 10, 2017: British Journal of Psychology
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