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https://www.readbyqxmd.com/read/29457367/sperm-morphological-normality-under-high-magnification-is-correlated-to-male-infertility-and-predicts-embryo-development
#1
B F Zanetti, D P A F Braga, R R Provenza, R C S Figueira, A Iaconelli, E Borges
Human sperm morphology has been described as an essential parameter for the diagnosis of male infertility and a prognostic indicator of natural or assisted pregnancies. Nevertheless, standard morphological assessment remains a subjective analysis and its impact on intracytoplasmic sperm injection (ICSI) is also of limited value. The objective of this prospective cohort study was to investigate whether motile sperm organelle morphology examination (MSOME) can improve semen analysis by better defining male infertility and providing a better prognosis for ICSI up to a year later...
February 18, 2018: Andrology
https://www.readbyqxmd.com/read/29457190/family-based-interventions-targeting-improvements-in-health-and-family-outcomes-of-children-and-adolescents-with-type-1-diabetes-a-systematic-review
#2
REVIEW
Marissa A Feldman, Lindsay M Anderson, Jenna B Shapiro, Aneta M Jedraszko, Meredyth Evans, Lindsey E G Weil, Kimberly P Garza, Jill Weissberg-Benchell
PURPOSE OF REVIEW: A systematic review was conducted of family-based interventions to improve glycemic control, adherence, and psychosocial outcomes in children and adolescents with type 1 diabetes (T1D). Electronic databases were searched for randomized controlled trials (RCTs) published since the seminal Diabetes Control and Compliance Trial (DCCT). Interventions are summarized and findings reviewed to help guide clinical practice and future research. RECENT FINDINGS: Twenty-five RCTs are reviewed...
February 19, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29456693/seminal-bacterial-composition-in-patients-with-obstructive-and-non-obstructive-azoospermia
#3
Houyang Chen, Tao Luo, Tingtao Chen, Gongxian Wang
A number of culture-dependent and -independent studies have reported that the number and significance of bacterial species in semen may have been underestimated. The aim of the present study was to profile the seminal microbiome in patients with obstructive or non-obstructive azoospermia. A high-throughput sequencing method was adopted to sequence genomic DNA extracted from the semen of healthy people (C group), patients with obstructive azoospermia (OA group) and patients with non-obstructive azoospermia (NOA group)...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455752/imagining-class-a-study-into-material-social-class-position-subjective-identification-and-voting-behavior-across-europe
#4
Lorenzo D'Hooge, Peter Achterberg, Tim Reeskens
The traditional approach to class voting has largely ignored the question whether material class positions coincide with subjective class identification. Following Sosnaud et al. (2013), this study evaluates party preferences when Europeans' material and subjective social class do not coincide. Seminal studies on voting behavior have suggested that members of lower classes are more likely to vote for the economic left and cultural right and that higher classes demonstrate the opposite pattern. Yet, these studies have on the one hand overlooked the possibility that there is a mismatch between the material class people can be classified in and the class they think they are part of, and on the other hand the consequences of this discordant class identification on voting behavior...
February 2018: Social Science Research
https://www.readbyqxmd.com/read/29455706/review-the-potential-of-seminal-fluid-mediated-paternal-maternal-communication-to-optimise-pregnancy-success
#5
J J Bromfield
Artificial insemination has been a landmark procedure in improving animal agriculture over the past 150 years. The utility of artificial insemination has facilitated a rapid improvement in animal genetics across agricultural species, leading to improvements of growth, health and productivity in poultry, swine, equine and cattle species. The utility of artificial insemination, as with all assisted reproductive technologies side-steps thousands of years of evolution that has led to the development of physiological systems to ensure the transmission of genetics from generation to generation...
February 19, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29453369/intratesticular-injection-followed-by-electroporation-allows-gene-transfer-in-caprine-spermatogenic-cells
#6
R Kumar Pramod, Abhijit Mitra
The production of transgenic livestock is constrained due to the limited success of currently available methods for transgenesis. Testis mediated gene transfer (TMGT) is an emerging method that shows a high success rate in generating transgenic mice. In this study, we report a newly developed protocol for electroporation-aided TMGT to produce a transgenic goat. The injectable volume and concentration of the transgene were first standardized, and then electroporation conditions were optimized in vitro. In vivo experiments were performed by injecting a transgenic construct (pIRES2-EGFP; enhanced green fluorescent protein) into the testicular interstitium followed by electroporation...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29451828/the-effect-of-omega-3-fatty-acids-epa-and-or-dha-on-male-infertility-a-systematic-review-and-meta-analysis
#7
Banafshe Hosseini, Mahdieh Nourmohamadi, Shima Hajipour, Mohsen Taghizadeh, Zatollah Asemi, Seyed Ali Keshavarz, Sadegh Jafarnejad
The objective was to evaluate the effect of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on sperm parameters including total sperm concentration, sperm motility, sperm DHA, and seminal plasma DHA concentration in infertile men. The literature search was conducted in PubMed, Google Scholar, and Scopus from January 1, 1990 to December 20, 2017. The systematic review and meta-analysis were based on randomized controlled trials in infertile men with DHA or EPA treatments, either alone or in combination with other micronutrients...
February 16, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29450923/organic-zinc-and-copper-supplementation-on-antioxidant-protective-mechanism-and-their-correlation-with-sperm-functional-characteristics-in-goats
#8
M Narasimhaiah, A Arunachalam, S Sellappan, V K Mayasula, P R Guvvala, S K Ghosh, V Chandra, J Ghosh, H Kumar
Trace minerals feeding had significant effects on sperm production and fertility with better absorption and proper utilization within the body for optimum reproductive function. Several studies have shown that more influenced trace elements in the diets of animals are copper (Cu) and zinc (Zn). Bucks showing deficiency of this mineral might affect the quality of semen production which in turn would affect the fertility. This experiment was thus designed to test the effects of organic Cu and Zn supplementation on antioxidants enzyme activities and sperm functional attributes in fresh semen of bucks...
February 15, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29448163/sperm-dna-fragmentation-an-early-and-reliable-marker-of-air-pollution
#9
Liana Bosco, Tiziana Notari, Giovanni Ruvolo, Maria C Roccheri, Chiara Martino, Rosanna Chiappetta, Domenico Carone, Giosuè Lo Bosco, Laura Carrillo, Salvatore Raimondo, Antonino Guglielmino, Luigi Montano
Environmental factors could have a key role in the continuous and remarkable decline of sperm quality observed in the last decades. This study compared the seminal parameters and sperm DFI in men living in areas with different levels of air pollution. Results demonstrate that both steel plants workers and patients living in a high polluted area show a mean percentage of sperm DNA fragmentation above 30%, highlighting a clear sperm damage. In this work, two different techniques were used to measure sperm DNA damage in patients' groups, finding in both cases a high sperm DFI in patients living in polluted areas...
February 7, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29444949/downregulation-of-eca-mir-128-in-seminal-exosomes-and-enhanced-expression-of-cxcl16-in-the-stallion-reproductive-tract-are-associated-with-long-term-persistence-of-equine-arteritis-virus
#10
Mariano Carossino, Pouya Dini, Theodore S Kalbfleisch, Alan T Loynachan, Igor F Canisso, Kathleen M Shuck, Peter J Timoney, R Frank Cook, Udeni B R Balasuriya
Equine arteritis virus (EAV) can establish long-term persistent infection in the reproductive tract of stallions and is shed in the semen. Previous studies showed that long-term persistence is associated with a specific allele of the CXCL16 gene ( CXCL16S ) and that persistent infection is maintained despite the presence of a local inflammatory and humoral and mucosal antibody responses. Here, we demonstrated that equine seminal exosomes (SEs) are enriched in a small subset of miRNAs. Most importantly, we demonstrated that long-term EAV persistence is associated with the downregulation of an SE-associated miRNA (eca-mir-128) and with an enhanced expression of CXCL16 in the reproductive tract, a putative target of eca-mir-128...
February 14, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29444628/assisting-the-investigation-of-stranger-rapes-predicting-the-criminal-record-of-u-k-stranger-rapists-from-their-crime-scene-behaviors
#11
Louise Almond, Michelle McManus, Amarat Bal, Freya O'Brien, Lee Rainbow, Mark Webb
Davies, Wittebrood, and Jackson (1997) were among the first to investigate whether offense behaviors are predictive of criminal history, with the findings of their paper then utilized by the National Crime Agency (NCA) Behavioral Investigative Advisors (BIAs) when assisting rape investigations. The aim of the study was to replicate this seminal paper with a larger contemporary sample of U.K. stranger rapists as identified by NCA. Data from 474 adult male stranger rapists were obtained in relation to 22 crime scene behaviors and nine preconviction variables...
February 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29443016/resurrection-of-dormant-daphnia-magna-protocol-and-applications
#12
Maria Cuenca Cambronero, Luisa Orsini
Long-term studies enable the identification of eco-evolutionary processes that occur over extended time periods. In addition, they provide key empirical data that may be used in predictive modelling to forecast evolutionary responses of natural ecosystems to future environmental changes. However, excluding a few exceptional cases, long-term studies are scarce because of logistic difficulties associated with accessing temporal samples. Temporal dynamics are frequently studied in the laboratory or in controlled mesocosm experiments with exceptional studies that reconstruct the evolution of natural populations in the wild...
January 19, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29440636/chronic-neutrophilic-leukemia-new-science-and-new-diagnostic-criteria
#13
REVIEW
Natasha Szuber, Ayalew Tefferi
Chronic neutrophilic leukemia (CNL) is a distinct myeloproliferative neoplasm defined by persistent, predominantly mature neutrophil proliferation, marrow granulocyte hyperplasia, and frequent splenomegaly. The seminal discovery of oncogenic driver mutations in CSF3R in the majority of patients with CNL in 2013 generated a new scientific framework for this disease as it deepened our understanding of its molecular pathogenesis, provided a biomarker for diagnosis, and rationalized management using novel targeted therapies...
February 13, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29440266/essential-immunologic-orchestrators-of-intestinal-homeostasis
#14
REVIEW
Lei Zhou, Gregory F Sonnenberg
Over the past 25 years, substantial advances have been made in our understanding of the cellular and molecular pathways that are essential to maintain a state of health in the mammalian gastrointestinal tract, an organ that is densely colonized by both immune cells and trillions of microbes. Seminal studies in the 1990s identified that several cytokines, antigen-presentation molecules, and components of the T cell receptor were necessary to prevent the development of spontaneous intestinal inflammation in mice...
February 9, 2018: Science Immunology
https://www.readbyqxmd.com/read/29439357/dale-schenk-one-year-anniversary-fighting-to-preserve-the-memories
#15
Cassia Overk, Eliezer Masliah
 It has been a year since we lost Dale Schenk on September 30, 2016. Dale's visionary work resulted in the remarkable discovery in 1999 that an experimental amyloid-β (Aβ) vaccine reduced the neurodegeneration in a transgenic model of Alzheimer's disease (AD). Following Dale's seminal work, several active and passive immunotherapies have since been developed and tested in the clinic for AD, Parkinson's disease (PD), and other neurodegenerative disorders. Here we provide a brief overview of the current state of development of immunotherapy for AD, PD, and other neurodegenerative disorders in the context of this anniversary...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29438491/new-insights-on-a-ngf-mediated-pathway-to-induce-ovulation-in-rabbits-oryctolagus-cuniculus
#16
Margherita Maranesi, Linda Petrucci, Leonardo Leonardi, Federica Piro, Pilar García Rebollar, Pilar Millán, Paolo Cocci, Cecilia Vullo, Francesco Parillo, Arlindo Moura, Gabriela Gonzalez Mariscal, Cristiano Boiti, Massimo Zerani
To investigate the ovulatory mechanisms triggered by raw semen in rabbits, we examined the expression of nerve growth factor (NGF)-a supposed ovulation-inducing factor (OIF)-and cognate receptors in anterior pituitary, ovary, and cervix as well as plasma NGF and LH concentrations. Six does/group were: sham-inseminated with sterile saline (PBS), naturally mated (NM), inseminated with raw semen alone (RS) or after lumbar anesthesia (ARS) or treatment with COX inhibitors (CIRS). Immunohistochemistry revealed positive signals for NGF and receptors in all tissues...
February 9, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29436852/comparing-photon-and-proton-based-hypofractioned-sbrt-for-prostate-cancer-accounting-for-robustness-and-realistic-treatment-deliverability
#17
Lee Goddard, Nils P Brodin, William R Bodner, Madhur Garg, Wolfgang A Tomé
OBJECTIVE: To investigate whether photon or proton based SBRT is the preferred modality for high dose hypofractionation prostate cancer treatment. Achievable dose distributions were compared when uncertainties in target positioning and range uncertainties were appropriately accounted for. METHODS: Ten patients with prostate cancer previously treated at our institution with photon SBRT using volumetric modulated arc therapy (VMAT) were identified. MRI images fused to the treatment planning CT allowed for accurate target and organ-at-risk (OAR) delineation...
February 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29430663/dna-hydroxymethylation-rate-in-the-ache-and-hoxc4-promoter-associated-with-human-sperm-quality
#18
Y Li, Y H Li, X Zhou, B Wu, J P Chen, Z K Wang, X Wang, H J Shi, R S Li
The relationship of altered DNA 5'-hydroxymethylation in human spermatozoa with seminal parameters remains unclear. The aim of the study was to investigate the association between the 5'-hydroxymethylcytosine (5hmC) rate in the promoters of acetylcholinesterase (AChE) and homeobox C4 (HoxC4) genes and human sperm concentration/motility. The study population consisted of three groups: asthenozoospermia (AZ), oligoasthenozoospermia (OAZ) and normozoospermia (NZ). The 5hmC rate in the promoter was measured by CCGG loci-dependent MspI/HpaII restriction mapping of glycosylation-modified sperm DNA combined with a hydroxymethylation-specific real-time polymerase chain reaction assay...
February 11, 2018: Andrologia
https://www.readbyqxmd.com/read/29429895/first-postoperative-psa-is-associated-with-outcomes-in-patients-with-node-positive-prostate-cancer-results-from-the-search-database
#19
Michelle L McDonald, Lauren E Howard, William J Aronson, Martha K Terris, Matthew R Cooperberg, Christopher L Amling, Stephen J Freedland, Christopher J Kane
OBJECTIVE: To analyze factors associated with metastases, prostate cancer-specific mortality, and all-cause mortality in pN1 patients. MATERIALS AND METHODS: We analyzed 3,642 radical prostatectomy patients within the Shared Equal Access Regional Cancer Hospital (SEARCH) database. Pathologic Gleason grade, number of lymph nodes (LN) removed, and first postoperative prostate-specific antigen (PSA) (<0.2 ng/ml or ≥0.2 ng/ml) were among covariates assessed. Cox regression was used to analyze the association between characteristics and survival outcomes...
February 8, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29429544/ebola-virus-localization-in-the-macaque-reproductive-tract-during-acute-ebola-virus-disease
#20
Donna L Perry, Louis M Huzella, John G Bernbaum, Michael R Holbrook, Peter B Jahrling, Katie R Hagen, Matthias J Schnell, Reed F Johnson
Sexual transmission of Ebola virus (EBOV) has been demonstrated more than a year after recovery from the acute phase of Ebola virus disease (EVD). The mechanisms underlying EBOV persistence and sexual transmission are not currently understood. Using the acute macaque model of EVD, we hypothesized EBOV would infect the reproductive tissues and sought to localize the infection in these tissues using immunohistochemistry and transmission electron microscopy. In four female and eight male macaques that succumbed to EVD between 6 and 9 days after EBOV challenge, we demonstrate widespread EBOV infection of the interstitial tissues and endothelium in the ovary, uterus, testis, seminal vesicle, epididymis, and prostate gland, with minimal associated tissue immune response or organ pathology...
February 6, 2018: American Journal of Pathology
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