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https://www.readbyqxmd.com/read/28449332/behavioural-disinhibition-in-the-general-population-during-the-antiretroviral-therapy-roll-out-in-sub-saharan-africa-systematic-review-and-meta-analysis
#1
REVIEW
Eva M Legemate, Jan A C Hontelez, Caspar W N Looman, Sake J De Vlas
OBJECTIVES: Improved life expectancy and reduced transmission probabilities due to ART may result in behavioural disinhibition - i.e. an increase in sexual risk behaviour in response to a perceived lower risk of HIV. We examined trends in sexual risk behaviour in the general population of sub-Saharan African countries 1999 - 2015. METHODS: We systematically reviewed scientific literature of sexual behaviour, and reviewed trends in Demographic and Health Surveys...
April 27, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28449232/safety-pharmacokinetics-and-pharmacologic-effects-of-the-selective-androgen-receptor-modulator-gsk2881078-in-healthy-men-and-postmenopausal-women
#2
Richard V Clark, Ann C Walker, Susan Andrews, Philip Turnbull, Jeffrey A Wald, Mindy H Magee
AIM: Selective androgen receptor modulators (SARMs) induce anabolic effects on muscle without the adverse effects of androgenic steroids. In this first-in-human study, we report safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of the SARM GSK2881078. METHODS: In Part A, healthy young men (n = 10) received a single dose of study drug (0 mg, 0.05 mg, 0.1 mg, 0.2 mg GSK2881078 or matching-placebo). In Part B, repeat-dose cohorts in men (n = 65) were 0...
April 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28448813/adverse-childhood-experiences-mental-health-and-excessive-alcohol-use-examination-of-race-ethnicity-and-sex-differences
#3
Rosalyn D Lee, Jieru Chen
Responses from N=60,598 interviews from the 2010 Behavioral Risk Factor Surveillance System (the 10 states and the District of Columbia that included the optional Adverse Childhood Experience (ACE) module) were used to test whether associations between childhood adversity and adult mental health and alcohol behaviors vary by race/ethnicity and sex. ACE items were categorized into two types - household challenges and child abuse. Outcomes were current depression, diagnosed depression, heavy drinking and binge drinking...
April 24, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28448668/prognostic-indication-of-sarcopenia-for-wound-complication-after-total-laryngectomy
#4
Virginie Achim, Jasper Bash, Alia Mowery, Alexander R Guimaraes, Ryan Li, Josh Schindler, Mark Wax, Peter Andersen, Daniel Clayburgh
Importance: Postoperative wound complications after total laryngectomy (TL) increase hospital stay, costs, and delay adjuvant therapy when indicated. Recently, sarcopenia has been identified as a predictor of postoperative complications in patients undergoing major surgery but has not been assessed in head and neck surgery patients. Objective: To determine the incidence of sarcopenia in patients with squamous cell carcinoma (SCC) undergoing TL and evaluate its association with the development of postoperative wound complications...
April 27, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28448601/determinants-of-coronary-flow-reserve-in-non-diabetic-patients-with-chest-pain-without-myocardial-perfusion-defects
#5
Helena U Westergren, Erik Michaëlsson, Juuso I Blomster, Tasso Miliotis, Sara Svedlund, Li-Ming Gan
BACKGROUND: Microvascular dysfunction could be responsible for chest pain in patients without myocardial perfusion defects. We evaluated microvascular function using ultrasound-assessed coronary flow reserve (CFR) in patients with chest pain and normal myocardial perfusion scintigram. Secondly, we investigated association between cardiovascular parameters and decreased CFR in a sex specific manner. METHODS: A total of 202 (128 women) non-diabetic patients with chest pain and suspected myocardial ischemia, but without myocardial perfusion defects on myocardial perfusion scintigram, were enrolled and underwent CFR examination and blood sampling...
2017: PloS One
https://www.readbyqxmd.com/read/28448081/association-between-satisfaction-with-state-of-health-and-meals-physical-condition-and-food-diversity-health-behavior-and-perceptions-of-shopping-difficulty-among-older-people-living-alone-in-japan
#6
M Ishikawa, T Yokoyama, Y Takemi, Y Fukuda, T Nakaya, K Kusama, N Yoshiike, M Nozue, K Yoshiba, N Murayama
OBJECTIVE: This study aimed to examine perceptions of shopping difficulty, and the relationships with satisfaction with state of health and meals, physical condition, food diversity and health behavior in older people living alone in Japan. DESIGN: A cross-sectional, multilevel survey was designed. The questionnaire was distributed by mail and self-completed by participants. SETTING: The sample was drawn from seven towns and cities across Japan...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28447931/time-trends-in-cardiometabolic-risk-factors-in-adults
#7
Jonas D Finger, Markus A Busch, Yong Du, Christin Heidemann, Hildtraud Knopf, Ronny Kuhnert, Thomas Lampert, Gert B M Mensink, Hannelore K Neuhauser, Angelika Schaffrath Rosario, Christa Scheidt-Nave, Anja Schienkiewitz, Julia Truthmann, Bärbel-Maria Kurth
BACKGROUND: Data from three representative health examination surveys in Germany were analyzed to examine secular trends in the prevalence and magnitude of cardiometabolic risk factors. METHODS: The target variables were the following cardiometabolic risk factors: lack of exercise, smoking, obesity, systolic blood pressure, total cholesterol, serum glucose, self-reported high blood pressure, hyperlipidemia, and diabetes, and the use of antihypertensive, cholesterol-lowering, and antidiabetic drugs...
October 21, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28447871/the-effects-of-specialization-and-sex-on-anterior-y-balance-performance-in-high-school-athletes
#8
Madeline M Miller, Jessica L Trapp, Eric G Post, Stephanie M Trigsted, Timothy A McGuine, M Alison Brooks, David R Bell
BACKGROUND: Sport specialization and movement asymmetry have been separately discussed as potential risk factors for lower extremity injury. Early specialization may lead to the development of movement asymmetries that can predispose an athlete to injury, but this has not been thoroughly examined. HYPOTHESIS: Athletes rated as specialized would exhibit greater between-limb anterior reach asymmetry and decreased anterior reach distance on the Y-balance test (YBT) as compared with nonspecialized high school athletes, and these differences would not be dependent on sex...
April 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28446420/measuring-sexual-behavior-stigma-to-inform-effective-hiv-prevention-and-treatment-programs-for-key-populations
#9
Shauna Stahlman, James R Hargreaves, Laurel Sprague, Anne L Stangl, Stefan D Baral
BACKGROUND: The levels of coverage of human immunodeficiency virus (HIV) treatment and prevention services needed to change the trajectory of the HIV epidemic among key populations, including gay men and other men who have sex with men (MSM) and sex workers, have consistently been shown to be limited by stigma. OBJECTIVE: The aim of this study was to propose an agenda for the goals and approaches of a sexual behavior stigma surveillance effort for key populations, with a focus on collecting surveillance data from 4 groups: (1) members of key population groups themselves (regardless of HIV status), (2) people living with HIV (PLHIV) who are also members of key populations, (3) members of nonkey populations, and (4) health workers...
April 26, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28445947/characteristics-and-comparison-of-colorectal-cancer-incidence-in-beijing-with-other-regions-in-the-world
#10
Zhongmin Li, Lei Yang, Changzheng Du, Xuedong Fang, Ning Wang, Jin Gu
BACKGROUND: Population-based epidemiologic studies about colorectal cancer are lacking in China. This study aims to provide a basis for colorectal cancer screening and prevention, through analysis and comparisons the characteristics of the trends in colorectal cancer incidence in Beijing and selected representative regions. RESULTS: The annual incidence rate in Beijing region increased significantly, from 9.40/100,000 in 1998 to 18.61/100,000 in 2012. The stratified rate showed that the incidence of distal colon adenocarcinoma increased substantially in men, especially in those aged > 75 years and residing in urban areas...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445898/dramatic-changes-over-time-of-methamphetamine-intake-in-a-german-hiv-positive-sample-of-men-who-have-sex-with-men-msm
#11
Henrike Dirks, Stefan Esser, Norbert Brockmeyer, Udo Bonnet, Fabrizio Schifano, Norbert Scherbaum
No abstract text is available yet for this article.
April 26, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28445810/circulating-cadmium-concentration-and-risk-of-aortic-aneurysms-a-nested-case-control-study-within-the-malm%C3%A3-diet-and-cancer-cohort
#12
Björn Fagerberg, Yan Borné, Gerd Sallsten, J Gustav Smith, Stefan Acosta, Margaretha Persson, Olle Melander, Niklas Forsgard, Anders Gottsäter, Bo Hedblad, Lars Barregard, Gunnar Engström
BACKGROUND AND AIMS: Diet and smoking expose the general population to cadmium (Cd), which is a toxic metal that accumulates in the arterial wall. In experimental studies, Cd causes reductions in proliferation of smooth muscle cells and cellular synthesis of procollagen. The aim of this study was to examine whether blood Cd levels, a valid measure of Cd exposure, are associated with increased risk of abdominal aortic aneurysm (AAA). METHODS: All middle-aged men and women enrolled in the Malmö Diet and Cancer study (n = 30 447) were followed from the baseline examination in 1991-1996 through 2009...
April 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28445437/an-exploratory-study-on-the-influence-of-psychopathological-risk-and-impulsivity-on-bmi-and-perceived-quality-of-life-in-obese-patients
#13
Renata Tambelli, Luca Cerniglia, Silvia Cimino, Giulia Ballarotto, Marinella Paciello, Carla Lubrano, Serena Marchitelli, Lucio Gnessi, Andrea Lenzi
The present study aimed to assess the psychological profiles of adult male and female obese patients, as well as to verify the possible influence of their psychopathological risk and impulsivity on their body mass index (BMI) and perceived quality of life. A total of 64 obese subjects accessing a center for care of their obesity were assessed through anthropometric and psychometric measurements. All anthropometric measures in men were higher than in women, while in turn, women showed higher psychopathological symptoms...
April 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28444829/disparities-in-hiv-1-transmitted-drug-resistance-detected-by-ultradeep-sequencing-between-men-who-have-sex-with-men-and-heterosexual-populations
#14
E Todesco, C Charpentier, M Bertine, M Wirden, A Storto, N Desire, M Grude, T Nguyen, S Sayon, Y Yazdanpanah, C Katlama, D Descamps, V Calvez, A G Marcelin
OBJECTIVES: Transmitted drug resistance (TDR) can impair the response to first-line antiretroviral therapy. In treatment-naïve patients chronically infected with HIV type 1 (HIV-1), it was previously shown through Sanger sequencing that TDR was more common in men who have sex with men (MSM) than in other transmission risk groups. We aimed to compare two HIV-1 transmission groups in terms of the presence of TDR mutations. METHODS: We investigated, through Sanger sequencing and ultradeep sequencing (UDS), the presence of resistance mutations, both in majority (> 20%) and in minority (1-20%) proportions, in 70 treatment-naïve MSM and 70 treatment-naïve heterosexual patients who recently screened positive for HIV-1...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444818/reduced-community-viral-load-does-not-coincide-with-a-reduction-in-the-rate-of-new-hiv-diagnoses-and-recent-infections-data-from-a-region-of-southern-italy
#15
L Monno, A Saracino, L Scudeller, C Santoro, G Brindicci, G Punzi, A Lagioia, S Lo Caputo, G Angarano
OBJECTIVES: We assessed whether changes in community viral load (CVL) over time were associated with the rate of new HIV diagnoses (NDs). METHODS: HIV-1-positive individuals referred to our institute and permanently residing in our province were considered for inclusion in the study. A total of 861 HIV-infected adults with at least one HIV RNA measurement (12 530 measurements in total) between 2008 and 2014 were included. Viraemia copy-years were calculated from all HIV RNA values for each patient using the trapezoidal rule; multiple CVL indicators were considered...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444714/is-testosterone-important-in-lut-function-in-men-and-women-ici-rs-2015
#16
REVIEW
Jasmin Katrin Badawi, Ruud Bosch, Jens Christian Djurhuus, Ann T Hanna-Mitchell
AIM: This review article is a collaborative report based upon the Authors' presentations and Group discussion on the role of testosterone (T) in the male and female lower urinary tract (LUT) which took place at the 6th International Consultation on Incontinence Research Society's (ICI-RS) annual meeting, in Bristol, UK (September 8-10, 2015). METHODS: It comprises overviews and opinions on both the current state of knowledge of the role of T in LUT function and dysfunction in both sexes...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28444704/how-does-lower-urinary-tract-dysfunction-lutd-affect-sexual-function-in-men-and-women-ici-rs-2015-part-2
#17
REVIEW
Apostolos Apostolidis, Angie Rantell, Ralf Anding, Ruth Kirschner-Hermanns, Linda Cardozo
AIM: To discuss available data on the links between LUTD and sexual dysfunction, what is still unknown about the causative effect of disease processes on sexual function (SF), and to suggest proposals for further research. METHODS: At the 2015 International Consultation on Incontinence-Research Society (ICI-RS), a multi-disciplinary group presented a literature search of what is known about the effect of LUTD on SF in men and women. Wider discussions regarding knowledge gaps, and ideal research methodology ensued and are presented...
April 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28444628/moving-beyond-age-an-exploratory-qualitative-study-on-the-context-of-young-african-american-men-and-women-s-sexual-debut
#18
Yzette Lanier, Jennifer M Stewart, Jean J Schensul, Barbara J Guthrie
African American youth continue to be disproportionately affected by HIV. Early sexual debut has been identified as a major determinant of HIV risk. However, emerging research suggests that the overarching context in which first sex occurs may have greater implications for sexual health than simply age alone. The purpose of this exploratory, qualitative study was to better understand the broader context of African Americans' sexual debut. In-depth, semi-structured interviews were conducted with 10 African American men and women aged 18-24 years...
April 25, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28444529/-we-deserve-better-perceptions-of-hiv-testing-campaigns-among-black-and-latino-msm-in-new-york-city
#19
Kathryn Drumhiller, Ashley Murray, Zaneta Gaul, Tiffiany M Aholou, Madeline Y Sutton, Jose Nanin
In 2014, Black/African-American and Hispanic/Latino men who have sex with men (BLMSM) comprised 64.1% of HIV diagnoses among MSM in the U.S. Routine HIV testing allows earlier diagnosis, linkage to care, and improved health outcomes. HIV testing campaigns may increase HIV awareness and testing behaviors, but perceptions of these campaigns by BLMSM have been understudied. We explored perceptions of HIV testing campaigns with BLMSM in New York City (NYC) to inform campaign strategies that target BLMSM for HIV testing...
April 25, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28444469/modelling-the-unaids-90-90-90-treatment-cascade-for-gay-bisexual-and-other-men-who-have-sex-with-men-in-south-africa-using-the-findings-of-a-data-triangulation-process-to-map-a-way-forward
#20
Andrew Scheibe, Michael Grasso, Henry Fisher Raymond, Albert Manyuchi, Thomas Osmand, Tim Lane, Helen Struthers
A data triangulation exercise was carried out between 2013 and 2015 to assess the HIV epidemic and response among gay, bisexual and other men who have sex with men (GBMSM) in South Africa. We used the findings to assess progress in achieving the UNAIDS 90-90-90 goals for GBMSM in the country. Three scenarios were developed using different GBMSM population factors (2.0, 3.5 and 5.0% of males aged ≥15) to estimate the population size, HIV prevalence of 13.2-49.5%, and 68% of GBMSM knowing their status. Due to data gaps, general population data were used as estimates of GBMSM on antiretroviral therapy (ART) and virologically suppressed (25...
April 25, 2017: AIDS and Behavior
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