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https://www.readbyqxmd.com/read/29458158/toll-like-receptor-tlr-9-promotor-polymorphisms-and-gene-expression-are-associated-with-persistent-staphylococcus-aureus-nasal-carriage
#1
Dennis Nurjadi, Klaus Heeg, Alexander N R Weber, Philipp Zanger
OBJECTIVES: Toll-like receptor (TLR) -9 could have importance in human S. aureus immunity, but population level evidence for this hypothesis is missing. METHODS: We phenotyped 603 volunteers for S. aureus nasal carriage using four consecutive swabs, genotyped TLR9 promotor variants in 106 persistent carriers and 219 non-carriers, measured TLR9-mRNA expression in whole blood after stimulation with viable S. aureus, and studied mutual associations of carriage, transcriptional activity, and single nucleotide polymorphisms while accounting for sex and hormonal contraceptive use (HCU+/- )...
February 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29458053/circulating-bile-acids-in-healthy-adults-respond-differently-to-a-dietary-pattern-characterized-by-whole-grains-legumes-and-fruits-and-vegetables-compared-to-a-diet-high-in-refined-grains-and-added-sugars-a-randomized-controlled-crossover-feeding-study
#2
Bigina N R Ginos, Sandi L Navarro, Yvonne Schwarz, Haiwei Gu, Dongfang Wang, Timothy W Randolph, Ali Shojaie, Meredith A J Hullar, Paul D Lampe, Mario Kratz, Marian L Neuhouser, Daniel Raftery, Johanna W Lampe
OBJECTIVE: The effects of diets high in refined grains on biliary and colonic bile acids have been investigated extensively. However, the effects of diets high in whole versus refined grains on circulating bile acids, which can influence glucose homeostasis and inflammation through activation of farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5), have not been studied. MATERIALS AND METHODS: We conducted a secondary analysis from a randomized controlled crossover feeding trial (NCT00622661) in 80 healthy adults (40 women/40 men, age 18-45 years) from the greater Seattle Area, half of which were normal weight (BMI 18...
February 16, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29457849/tobacco-attributable-burden-of-cancer-according-to-socioeconomic-position-in-france
#3
Gwenn Menvielle, Ivana Kulhánová, Joséphine Bryère, Guy Launoy, Daniel Eilstein, Cyrille Delpierre, Isabelle Soerjomataram
Smoking is a major preventable cause of cancers and is increasingly concentrated among the most deprived individuals leading to increasing socioeconomic inequalities in the incidence of cancers linked to smoking. We aimed to estimate the tobacco-attributable cancer burden according to socioeconomic position in France. The analysis was restricted to cancer sites for which tobacco smoking was recognized as a risk factor. Cancer cases by sex, age group and European Deprivation Index (EDI) among people aged 30-74 between 2006 and 2009 were obtained from cancer registries covering approximately 20% of the French population...
February 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29456896/factors-associated-with-elevated-blood-pressure-or-hypertension-in-afro-caribbean-youth-a-cross-sectional-study
#4
Trevor S Ferguson, Novie O M Younger-Coleman, Marshall K Tulloch-Reid, Nadia R Bennett, Amanda E Rousseau, Jennifer M Knight-Madden, Maureen E Samms-Vaughan, Deanna E Ashley, Rainford J Wilks
Background: Although several studies have identified risk factors for high blood pressure (BP), data from Afro-Caribbean populations are limited. Additionally, less is known about how putative risk factors operate in young adults and how social factors influence the risk of high BP. In this study, we estimated the relative risk for elevated BP or hypertension (EBP/HTN), defined as BP ≥ 120/80 mmHg, among young adults with putative cardiovascular disease (CVD) risk factors in Jamaica and evaluated whether relative risks differed by sex...
2018: PeerJ
https://www.readbyqxmd.com/read/29456091/frequency-of-human-papillomavirus-infection-in-patients-with-gastrointestinal-cancer
#5
F Roesch-Dietlen, A D Cano-Contreras, Y J Sánchez-Maza, J M Espinosa-González, M Á Vázquez-Prieto, E J Valdés-de la O, F Díaz-Roesch, M Á Carrasco-Arroniz, A Cruz-Palacios, P Grube-Pagola, A Sumoza-Toledo, H Vivanco-Cid, G Mellado-Sánchez, A Meixueiro-Daza, C S Silva-Cañetas, M G Carrillo-Toledo, R Lagunes-Torres, M Amieva-Balmori, P C Gómez-Castaño, J U Reyes-Huerta, J M Remes-Troche
INTRODUCTION AND AIM: Cancer is the result of the interaction of genetic and environmental factors. It has recently been related to viral infections, one of which is human papillomavirus. The aim of the present study was to describe the frequency of human papillomavirus infection in patients with digestive system cancers. MATERIALS AND METHODS: A prospective, multicenter, observational study was conducted on patients with gastrointestinal cancer at 2public healthcare institutes in Veracruz...
February 15, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29455688/early-life-nutritional-status-and-metabolic-syndrome-gender-specific-associations-from-a-cross-sectional-analysis-of-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#6
Bruna Lucas Briskiewicz, Sandhi Maria Barreto, Joana Ferreira do Amaral, Maria de Fátima Haueisen Sander Diniz, Maria Del Carmen Bisi Molina, Sheila Maria Alvim Matos, Letícia de Oliveira Cardoso, Gustavo Velasquez-Melendez, Maria Inês Schmidt, Luana Giatti
OBJECTIVE: In the present study we investigated gender-specific associations of low birth weight (LBW) and shorter relative leg length with metabolic syndrome (MetS) after adjusting for sociodemographic characteristics and health-related behaviours. We also investigated whether these associations are independent of age at menarche and BMI at 20 years old. DESIGN: Cross-sectional analysis. SUBJECTS: Baseline data from 12 602 participants (35-74 years) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), 2008-2010...
February 19, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29455057/the-impact-of-body-composition-pain-and-resilience-on-physical-activity-physical-function-and-physical-performance-at-2-months-post-hip-fracture
#7
Barbara Resnick, J Richard Hebel, Ann L Gruber-Baldini, Gregory E Hicks, Marc C Hochberg, Denise Orwig, Marty Eastlack, Jay Magaziner
The purpose of this study was to test a model of the factors influencing physical activity, physical function and physical performance at 2 months post hip fracture and compare model fit between men and women. Age, cognitive status, comorbidities, pain, resilience, bone mineral density, total body lean mass, total body fat and grip strength were hypothesized to be directly and/or indirectly related to physical activity, physical function and physical performance. This analysis used data from the seventh Baltimore Hip Studies (BHS-7), a prospective cohort study that included 258 community-dwelling participants, 125 (48%) men and 133 (52%) women, hospitalized for treatment of a hip fracture; survey and objective data were obtained at 2 months post hip fracture...
February 15, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29454928/resting-state-functional-connectivity-of-the-amygdala-and-problem-drinking-in-non-dependent-alcohol-drinkers
#8
Sien Hu, Jaime S Ide, Herta H Chao, Simon Zhornitsky, Kimberly A Fischer, Wuyi Wang, Sheng Zhang, Chiang-Shan R Li
Alcohol misuse is associated with dysfunction of the amygdala-prefrontal cortical circuit. The amygdala and its cortical targets show decreased activity during a variety of task challenges in individuals engaged in problem drinking. On the other hand, it is less clear how amygdala resting state functional connectivity (rsFC) may be altered in association with alcohol misuse and whether such changes are restricted to prefrontal cortical structures. Further, the influences of comorbid substance use and depression and potential sex differences have not been assessed in earlier work...
February 7, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29454927/syndemics-among-individuals-enrolled-in-the-prep-brasil-study
#9
Raquel B De Boni, Iona K Machado, Mauricio T L De Vasconcellos, Brenda Hoagland, Esper G Kallas, José Valdez Madruga, Nilo M Fernandes, Natalia B Cerqueira, Ronaldo I Moreira, Silvia P Goulart, Valdilea G Veloso, Beatriz Grinsztejn, Paula M Luz
BACKGROUND: Concurrent psychosocial problems may synergistically increase the risk of HIV infection (syndemics), representing a challenge for prevention. We aimed to evaluate the prevalence and associated factors of syndemics among men who have sex with men (MSM) and transgender women (TGW) enrolled in the Brazilian pre-exposure prophylaxis demonstration study (PrEP Brasil Study). METHODS: Secondary cross-sectional analysis of the PrEP Brasil Study was performed...
February 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29454634/feminizing-genital-gender-confirmation-surgery
#10
REVIEW
Miriam Hadj-Moussa, Dana A Ohl, William M Kuzon
INTRODUCTION: For many patients with gender dysphoria, gender-confirmation surgery (GCS) helps align their physical characteristics with their gender identity and is a fundamental element of comprehensive treatment. This article is the 2nd in a 3-part series about the treatment of gender dysphoria. Non-operative management was covered in part 1. This section begins broadly by reviewing surgical eligibility criteria, benefits of GCS, and factors associated with regret for transgender men and women...
February 14, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29454594/low-magnesium-intake-is-associated-with-increased-knee-pain-in-subjects-with-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#11
Anna Shmagel, Naoko Onizuka, Lisa Langsetmo, Tien Vo, Robert Foley, Kristine Ensrud, Peter Valen
OBJECTIVE: As magnesium mediates bone and muscle metabolism, inflammation, and pain signaling, we aimed to evaluate whether magnesium intake is associated with knee pain and function in radiographic knee osteoarthritis. METHODS: We investigated the associations between knee pain/function metrics and magnesium intake from food and supplements in 2548 Osteoarthritis Initiative cohort participants with prevalent radiographic knee OA (Kellgren-Lawrence score ≥2). Magnesium intake was assessed by Food Frequency Questionnaire at baseline...
February 15, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29454322/using-ehealth-to-engage-and-retain-priority-populations-in-the-hiv-treatment-and-care-cascade-in-the-asia-pacific-region-a-systematic-review-of-literature
#12
Julianita Purnomo, Katherine Coote, Limin Mao, Ling Fan, Julian Gold, Raghib Ahmad, Lei Zhang
BACKGROUND: The exponential growth in the reach and development of new technologies over the past decade means that mobile technologies and social media play an increasingly important role in service delivery models to maximise HIV testing and access to treatment and care. This systematic review examines the impact of electronic and mobile technologies in medical care (eHealth) in the linkage to and retention of priority populations in the HIV treatment and care cascade, focussing on the Asia-Pacific region...
February 17, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29454241/frailty-and-life-course-violence-the-international-mobility-in-aging-study
#13
Cristiano Dos Santos Gomes, Catherine McLean Pirkle, Maria Vitoria Zunzunegui, Dimitri Taurino Guedes, Juliana Fernandes De Souza Barbosa, Phoebe Hwang, Ricardo Oliveira Guerra
OBJECTIVE: To estimate the prevalence of frailty in older adults in the IMIAS population, to examine associations between lifelong domestic violence and frailty and possible pathways to explain these associations. METHODS: A cross-sectional study with 2002 men and women in the International Mobility in Aging Study, aged between 65 and 74 years old living in five cities of Tirana (Albania), Natal (Brazil), Kingston and Saint-Hyacinthe (Canada), and Manizales (Colombia)...
February 8, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29453953/concept-analysis-of-responsible-sexual-behavior-in-adult-women
#14
Melissa Lehan Mackin, Nicole Loew, Lioness Ayres
The concept of responsible sexual behavior is not clearly defined as it applies to adult women who have sex with men. Responsible sexual behavior is a socially desirable and deliberate pattern of behaviors used to promote sexual health, manage risk, and foster respect for sexual partners within the context of community influences. A purposeful redefinition may be necessary to maintain a concept that is useful and effective for evaluating sexual behavior.
February 14, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29453873/association-between-pemphigus-and-neurologic-diseases
#15
Khalaf Kridin, Shira Zelber-Sagi, Doron Comaneshter, Arnon D Cohen
Importance: The association between pemphigus and neurologic diseases was not evaluated systematically in the past. In a recent uncontrolled cross-sectional study, Parkinson disease was found to be significantly associated with pemphigus; in the same study, epilepsy had a nonsignificant association with pemphigus. Several case reports have suggested that pemphigus coexists with multiple sclerosis and dementia. Objective: To estimate the association between pemphigus and 4 neurologic conditions (dementia, epilepsy, Parkinson disease, and multiple sclerosis), using one of the largest cohorts of patients with pemphigus...
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29453551/characterization-of-hiv-recent-infection-among-high-risk-men-at-public-sti-clinics-in-mumbai
#16
Hong-Ha M Truong, Robin Fatch, Robert M Grant, Meenakshi Mathur, Sameer Kumta, Hemangi Jerajani, Timothy A Kellogg, Christina P Lindan
We examined associations with HIV recent infection and estimated transmitted drug resistance (TDR) prevalence among 3345 men at sexually transmitted infection clinics in Mumbai (2002-2005). HIV seroincidence was 7.92% by the BED-CEIA and was higher at a clinic located near brothels (12.39%) than at a hospital-based clinic (3.94%). HIV recent infection was associated with a lifetime history of female sex worker (FSW) partners, HSV-2, genital warts, and gonorrhea. TDR prevalence among recent infection cases was 5...
February 16, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29452966/gender-differences-in-the-relationship-of-childhood-trauma-and-the-course-of-illness-in-schizophrenia
#17
Krisztina Kocsis-Bogár, Veronika Mészáros, Dóra Perczel-Forintos
INTRODUCTION: Different types of childhood trauma have been repeatedly shown to contribute to psychotic symptoms. Gender differences in schizophrenia are well known. Some studies argue that trauma history means a significantly higher risk of psychosis for women than men. However, there is evidence of early adverse life events to be associated with higher stress-sensitivity in men. Little is known about the connection of specific type of trauma and specific psychotic symptoms as well as the course of illness with explicit regard to gender differences...
February 13, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29452784/abdominal-aortic-aneurysm-sex-differences
#18
REVIEW
Christina Villard, Rebecka Hultgren
OBJECTIVE: Abdominal aortic aneurysm (AAA) predominantly affects an elderly male population. Even so, AAA appears more detrimental in women, who experience a higher risk of aneurysm rupture and a worse outcome after surgery than men. Why women are privileged from yet are worse off once affected has been attributed to an effect of sex hormones. This review summarizes the knowledge of sex differences in AAA and addresses the changes in the aneurysm wall from a gender perspective. METHOD: Standard reporting guidelines set by the PRISMA Group were followed to identify studies examining AAA from a gender perspective...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29452782/multimorbidity-and-quality-of-life-at-mid-life-a-systematic-review-of-general-population-studies
#19
REVIEW
Jeeva Kanesarajah, Michael Waller, Jennifer A Whitty, Gita D Mishra
There is substantial multimorbidity at mid-life but little is known about the strength of evidence on multimorbidity and health-related quality of life (HrQoL) at mid-life. This review addresses this gap, focusing on studies of the general population. PubMed, Web of Science, Embase and APA PsycNET databases were screened on 6 March 2017 for original research on multimorbidity and HrQoL in adults aged 40-65 years from the general population. Studies focused on index conditions, using single-item HrQoL measures, unlikely to represent the general population (e...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29452705/the-changing-incidence-and-presentation-of-urinary-stones-over-3-decades
#20
Wonngarm Kittanamongkolchai, Lisa E Vaughan, Felicity T Enders, Tsering Dhondup, Ramila A Mehta, Amy E Krambeck, Cynthia H McCollough, Terri J Vrtiska, John C Lieske, Andrew D Rule
OBJECTIVE: To evaluate trends in the incidence of kidney stones and characteristics associated with changes in the incidence rate over 3 decades. PATIENTS AND METHODS: Adult stone formers in Olmsted County, Minnesota, from January 1, 1984, to December 31, 2012, were validated and characterized by age, sex, stone composition, and imaging modality. The incidence of kidney stones per 100,000 person-years was estimated. Characteristics associated with changes in the incidence rate over time were assessed using Poisson regression models...
February 6, 2018: Mayo Clinic Proceedings
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