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https://www.readbyqxmd.com/read/29142799/respiratory-failure-following-organophosphate-poisoning-a-literature-review
#1
REVIEW
Pirthvi Raj Giyanwani, Ujala Zubair, Osama Salam, Zarafshan Zubair
Organophosphates (OPs) account for a large portion of suicides globally. OP manifests as cholinergic crises, which underlie respiratory failure. There are many pathways by which respiration is inhibited secondary to organophosphate poisoning. These include central as well as peripheral mechanisms, with central mechanisms predominating. We conducted a literature review in June 2017. PubMed, Embase, and Google Scholar were searched for studies that reported acute organophosphate poisoning in humans. In our review, data were collected from studies published during the years 2001 to 2016...
September 3, 2017: Curēus
https://www.readbyqxmd.com/read/29140751/further-delineation-of-the-oculoauricular-syndrome-phenotype-a-new-family-with-a-novel-truncating-hmx1-mutation
#2
Ghada M H Abdel-Salam, Mohamed S Abdel-Hamid, Mennat I Mehrez, Ahmad M Kamal, Mohamed B Taher, Hanan H Afifi
Biallelic HMX1 mutations cause a very rare autosomal recessive genetic disorder termed as oculoauricular syndrome (OAS) because it is characterized only by the combination of eye and ear anomalies. We identified a new family bringing to three the total families reported with this disorder. Our proband presented with anteriorly protruded ears and malformed ear pinnae in association with microphthalmia, congenital cataract, microcornea, and iris and optic disc colobomata. Additionally, he had high and broad forehead with asymmetry giving a recognizable facial gestalt...
November 15, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29125456/microbacterium-album-sp-nov-and-microbacterium-deserti-sp-nov-two-halotolerant-actinobacteria-isolated-from-desert-soil
#3
Zi-Wen Yang, Nimaichand Salam, Mohamed Mohany, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Min Xiao, Wael N Hozzein, Wen-Jun Li
Strains SYSU D8007(T) and SYSU D8014(T) were isolated from desert soil collected from Saudi Arabia. The two isolates were Gram-stain-positive, non-motile, aerobic and non-spore-forming. These strains were able to grow at 4-45 °C and in the presence of up to 8 % (w/v) NaCl. Strain SYSU D8007(T) could grow at pH 6.0-10.0, and strain SYSU D8014(T) at pH 5.0-10.0. They shared highest 16S rRNA gene sequence similarities with Microbacterium marinilacus YM11-607(T) and Microbacterium paludicola US15(T). Menaquinones MK-11 and MK-12 were detected as the respiratory quinones...
November 10, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29124324/the-effect-of-mental-fatigue-on-critical-power-during-cycling-exercise
#4
Hawbeer Salam, Samuele M Marcora, James G Hopker
PURPOSE: Time to exhaustion (TTE) tests used in the determination of critical power (CP) and curvature constant (W') of the power-duration relationship are strongly influenced by the perception of effort (PE). This study aimed to investigate whether manipulation of the PE alters the CP and W'. METHODS: Eleven trained cyclists completed a series of TTE tests to establish CP and W' under two conditions, following a mentally fatiguing (MF), or a control (CON) task...
November 9, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29119631/safety-and-efficacy-of-early-start-of-iron-chelation-therapy-with-deferiprone-in-young-children-newly-diagnosed-with-transfusion-dependent-thalassemia-a-randomized-controlled-trial
#5
Mohsen Saleh Elalfy, Amira Adly, Hanem Awad, Mohamed Tarif Salam, Vasilios Berdoukas, Fernando Tricta
Iron overload is inevitable in patients who are transfusion dependent. In young children with transfusion-dependent thalassemia (TDT), current practice is to delay the start of iron chelation therapy due to concerns over toxicities, which have been observed when deferoxamine was started too early. However, doing so may increase the risk of iron accumulation that will be manifested as toxicities later in life. This study investigated whether deferiprone, a chelator with a lower affinity for iron than deferoxamine, could postpone transfusional iron overload while maintaining a good safety profile...
November 9, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29101611/pre-existing-small-vessel-disease-in-patients-with-acute-stroke-from-the-middle-east-southeast-asia-and-philippines
#6
Naveed Akhtar, Abdul Salam, Saadat Kamran, Atlantic D'Souza, Yahia Imam, Ahmed Own, Ahmed ElSotouhy, Surjith Vattoth, Paula Bourke, Zain Bhutta, Sujatha Joseph, Mark Santos, Rabia Ali Khan, Ashfaq Shuaib
Asymptomatic small vessel disease (SVD), including white matter hyperintensities (WMHIs), periventricular hyperintensities (PVHIs), silent stroke (SS), and cerebral microbleeds (CMBs), increases the risk of stroke. There are limited studies of SVD in subjects from the Middle East and Southeast Asia (SA). All patients admitted to stroke service between 2014 and 2015 were reviewed for presence of "pre-existing" SVD. Stroke mimics with no previous history of stroke were used as controls. There were 1727 patients admitted with stroke...
November 3, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29100544/effects-of-selected-palestinian-plants-on-the-in-vitro-exsheathment-of-the-third-stage-larvae-of-gastrointestinal-nematodes
#7
Rana Majed Jamous, Mohammed Saleem Ali-Shtayeh, Salam Yousef Abu-Zaitoun, Alex Markovics, Hassan Azaizeh
BACKGROUND: Gastrointestinal parasites are one of the main restrictions to small ruminant production. Their pathological importance is primarily related to the major production losses, in quantity or quality, induced by the direct action of worms. Control of these parasites is based exclusively on the frequent use of anthelmintic drugs. However, the resistance to anthelmintics in worm populations after commercialisation of chemical drugs is now widespread. Therefore, there is a need to find new natural resources to ensure sustainable and effective treatment and control of these parasites...
November 3, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29098799/prenatal-traffic-related-air-pollution-exposures-cord-blood-adipokines-and-infant-weight
#8
T L Alderete, A Y Song, T Bastain, R Habre, C M Toledo-Corral, M T Salam, F Lurmann, F D Gilliland, C V Breton
OBJECTIVE: Studies suggest that prenatal exposure to traffic-related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early-life weight gain. METHODS: The Maternal and Child Health Study birth cohort included 136 women from the Los Angeles County + University of Southern California Medical Center. This study estimated prenatal residential TRAP exposure and used linear regression analysis to examine associations between adipokines with TRAP exposure and infant weight change (birth to 6 months)...
November 3, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/29091482/image-once-print-thrice-three-dimensional-printing-of-replacement-parts
#9
Timothy M Rankin, Blair A Wormer, John D Miller, Nicholas A Giovinco, Salam Al Kassis, David G Armstrong
OBJECTIVE: The last 20 years has seen an exponential increase in 3D printing as it pertains to the medical industry and more specifically surgery. Previous reviews in this domain have chosen to focus on applications within a specific field. To our knowledge none have evaluated the broad applications of patient-specific or Digital Imaging and Communications in Medicine (DICOM) derived applications of this technology. METHODS: We searched PUBMED and CINAHL from April 2012 up to April 2017...
November 1, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29077657/does-portopulmonary-hypertension-impede-liver-transplantation-in-cirrhotic-patients-a-french-multicentric-retrospective-study
#10
Maud Reymond, Louise Barbier, Ephrem Salame, Camille Besh, Jerome Dumortier, Georges-Philippe Pageaux, Christophe Bureau, Sébastien Dharancy, Claire Vanlemmens, Armand Abergel, Marie-Lorraine Woehl Jaegle, Pascal Magro, Frederic Patat, Emeline Laurent, Jean-Marc Perarnau
BACKGROUND: Portopulmonary hypertension is defined by the presence of pulmonary arterial hypertension associated with portal hypertension. Its presence is a major stake for cirrhotic patients requiring liver transplantation, with increased postoperative mortality and unpredictable evolution after transplantation. The aim was to study outcomes after liver transplantation in patients with portopulmonary hypertension and to identify factors associated with normalization of pulmonary hypertension...
October 26, 2017: Transplantation
https://www.readbyqxmd.com/read/29076669/diabetic-ketoacidosis-characteristics-and-differences-in-type-1-versus-type-2-diabetes-patients
#11
Muhammad Owais Rashid, Aisha Sheikh, Abdus Salam, Saad Farooq, Zareen Kiran, Najmul Islam
BACKGROUND: Diabetes is undoubtedly one of the most challenging health problems of the 21st century. It is well known that diabetes once develop can lead to several complications. Diabetic ketoacidosis (DKA) is one of the life-threatening complications of diabetes. This study was designed to determine the frequency of DKA in diabetes patients and find out the clinical and biochemical determinants of DKA. METHODS: This descriptive study was conducted at Aga Khan University Hospital (AKUH) Karachi, Pakistan from January 2010 to February 2016...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29074256/synthesis-anticancer-structural-and-computational-docking-studies-of-3-benzylchroman-4-one-derivatives
#12
Lalitha Simon, Abdul Ajees Abdul Salam, S Madan Kumar, T Shilpa, K K Srinivasan, K Byrappa
A series of 3-Benzylchroman-4-ones were synthesized and screened for anticancer activity by MTT assay. The compounds were evaluated against two cancerous cell lines BT549 (human breast carcinoma), HeLa (human cervical carcinoma), and one noncancerous cell line vero (normal kidney epithelial cells). 3b was found to be the most active molecule against BT549 cells (IC50 = 20.1 µM) and 3h against HeLa cells (IC50 = 20.45 µM). 3b also exhibited moderate activity against HeLa cells (IC50 = 42.8 µM)...
October 16, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29073228/using-a-whole-body-31p-birdcage-transmit-coil-and-16-element-receive-array-for-human-cardiac-metabolic-imaging-at-7t
#13
Ladislav Valkovič, Iulius Dragonu, Salam Almujayyaz, Alex Batzakis, Liam A J Young, Lucian A B Purvis, William T Clarke, Tobias Wichmann, Titus Lanz, Stefan Neubauer, Matthew D Robson, Dennis W J Klomp, Christopher T Rodgers
PURPOSE: Cardiac phosphorus magnetic resonance spectroscopy (31P-MRS) provides unique insight into the mechanisms of heart failure. Yet, clinical applications have been hindered by the restricted sensitivity of the surface radiofrequency-coils normally used. These permit the analysis of spectra only from the interventricular septum, or large volumes of myocardium, which may not be meaningful in focal disease. Löring et al. recently presented a prototype whole-body (52 cm diameter) transmit/receive birdcage coil for 31P at 7T...
2017: PloS One
https://www.readbyqxmd.com/read/29062553/impact-of-educational-activities-in-reducing-pre-analytical-laboratory-errors-a-quality-initiative
#14
Hamed Al-Ghaithi, Anil Pathare, Sahimah Al-Mamari, Rodrigo Villacrucis, Naglaa Fawaz, Salam Alkindi
OBJECTIVES: Pre-analytic errors during diagnostic laboratory investigations can lead to increased patient morbidity and mortality. This study aimed to ascertain the effect of educational nursing activities on the incidence of pre-analytical errors resulting in non-conforming blood samples. METHODS: This study was conducted between January 2008 and December 2015. All specimens received at the Haematology Laboratory of the Sultan Qaboos University Hospital, Muscat, Oman, during this period were prospectively collected and analysed...
August 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29062550/first-cytogenetic-profile-of-omani-patients-with-de-novo-myelodysplastic-syndromes-comparison-with-data-from-asia-africa-europe-and-north-and-south-america
#15
Achandira M Udayakumar, Nagla Fawaz, Anil Pathare, Shakila Asraf, Mohammed Al-Huneini, Khalil Al-Farsi, Salam Al-Kindi, Murtadha Al-Khabouri
Clonal cytogenetic abnormalities have been reported among 30-80% of patients with myelodysplastic syndromes (MDS); however, 20-70% of patients with MDS show a normal karyotype that may nevertheless harbour a cryptic genetic alteration. Earlier reports have suggested that the distribution of specific chromosomal aberrations varies among Western and Asian countries, with geographical and ethnic differences in the frequency of specific chromosomal aberrations. This article compared the cytogenetic data of 36 adult Omani patients with MDS to previously reported data from other populations...
August 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29060665/robust-motion-artefact-resistant-circuit-for-calculation-of-mean-arterial-pressure-from-pulse-transit-time
#16
Tinish Bhattacharya, Ankesh Gupta, Salam ThoiThoi Singh, Sitikantha Roy, Anamika Prasad
Cuff-less and non-invasive methods of Blood Pressure (BP) monitoring have faced a lot of challenges like stability, noise, motion artefact and requirement for calibration. These factors are the major reasons why such devices do not get approval from the medical community easily. One such method is calculating Blood Pressure indirectly from pulse transit time (PTT) obtained from electrocardiogram (ECG) and Photoplethysmogram (PPG). In this paper we have proposed two novel analog signal conditioning circuits for ECG and PPG that increase stability, remove motion artefacts, remove the sinusoidal wavering of the ECG baseline due to respiration and provide consistent digital pulses corresponding to blood pulses/heart-beat...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055085/current-use-of-baseline-medical-treatment-in-chronic-rhinosinusitis-data-from-the-national-chronic-rhinosinusitis-epidemiology-study-cres
#17
Carl Philpott, Sally Erskine, Rupert Smith, Claire Hopkins, Naveed Kara, Amir Farboud, Mahmoud Salam, Alasdair Robertson, Rob Almeyda, B Nirmal Kumar, Shahram Anari, Jaydip Ray, Russell Cathcart, Sean Carrie, Shahzada Ahmed, Hisham Khalil, Allan Clark, Mike Thomas
OBJECTIVES: According to clinical and comissioning guidelines for chronic rhinosinusitis (CRS), patients being referred to secondary care should have failed primary medical treatment with nasal douching (ND) and intranasal corticosteroids (INCS). The study objectives were to identify the rate of specific medical therapy in CRS patients and establish any differences in medication use, for both CRS and associated medical conditions, between CRS phenotypes. DESIGN AND SETTING: Case-control study in a secondary care setting...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29053419/enhanced-sanitation-standard-operating-procedures-have-limited-impact-on-listeria-monocytogenes-prevalence-in-retail-delis
#18
Andrea J Etter, Susan R Hammons, Sherry Roof, Courtenay Simmons, Tongyu Wu, Peter W Cook, Alex Katubig, Matthew J Stasiewicz, Emily Wright, Steven Warchocki, Jill Hollingworth, Hilary S Thesmar, Salam A Ibrahim, Martin Wiedmann, Haley F Oliver
In a recent longitudinal surveillance study in 30 U.S. retail delicatessens, 9.7% of environmental surfaces were positive for Listeria monocytogenes, and we found substantial evidence of persistence. In this study, we aimed to reduce the prevalence and persistence of L. monocytogenes in the retail deli environment by developing and implementing practical and feasible intervention strategies (i.e., sanitation standard operating procedures; SSOPs). These SSOPs were standardized across the 30 delis enrolled in this study...
October 20, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29051847/symbiotic-bacteria-associated-with-puffer-fish-gastrophysus-spadiceus-and-evaluation-of-their-antimicrobial-activities
#19
Yi-Huan Wang, Nimaichand Salam, Qing Liu, Zi-Wen Yang, Li-Xiang Cao, Xiao-Lin Meng, Guo-Xing Nie, Jian-Hua Ju, Wen-Jun Li
The present study reports the diversity of culturable bacteria associated with the puffer fish Gastrophysus spadiceus. During the study, a total of 31 strains affiliated to the genera Pseudomonas, Janthinobacterium, Rahnella, and Psychrobacter were isolated from liver, intestines, and flesh of G. spadiceus. These strains exhibited a diverse range of metabolites as indicated by the HPLC and TLC profiles of the chemical extracts of their fermentation products. Some of these crude extracts showed strong antimicrobial activities against pathogenic bacterial strains...
December 2017: 3 Biotech
https://www.readbyqxmd.com/read/29048276/the-breadth-of-viruses-in-human-semen
#20
Alex P Salam, Peter W Horby
Zika virus RNA is frequently detected in the semen of men after Zika virus infection. To learn more about persistence of viruses in genital fluids, we searched PubMed for relevant articles. We found evidence that 27 viruses, across a broad range of virus families, can be found in human semen.
November 2017: Emerging Infectious Diseases
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