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https://www.readbyqxmd.com/read/28070634/increasing-the-reference-populations-for-the-55-aisnp-panel-the-need-and-benefits
#1
Andrew J Pakstis, Longli Kang, Lijun Liu, Zhiying Zhang, Tianbo Jin, Elena L Grigorenko, Frank R Wendt, Bruce Budowle, Sibte Hadi, Mariam Salam Al Qahtani, Niels Morling, Helle Smidt Mogensen, Goncalo E Themudo, Usha Soundararajan, Haseena Rajeevan, Judith R Kidd, Kenneth K Kidd
Ancestry inference for an individual can only be as good as the reference populations with allele frequency data on the SNPs being used. If the most relevant ancestral population(s) does not have data available for the SNPs studied, then analyses based on DNA evidence may indicate a quite distantly related population, albeit one among the more closely related of the existing reference populations. We have added reference population allele frequencies for 14 additional population samples (with >1100 individuals studied) to the 125 population samples previously published for the Kidd Lab 55 AISNP panel...
January 9, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28069844/adults-are-more-likely-to-become-eligible-for-medicaid-during-future-recessions-if-their-state-expanded-medicaid
#2
Paul D Jacobs, Steven C Hill, Salam Abdus
Eligibility for and enrollment in Medicaid can vary with economic recessions, recoveries, and changes in personal income. Understanding how Medicaid responds to such forces is important to budget analysts and policy makers tasked with forecasting Medicaid enrollment. We simulated eligibility for Medicaid for the period 2005-14 in two scenarios: assuming that each state's eligibility rules in 2009, the year before passage of the Affordable Care Act (ACA), were in place during the entire study period; and assuming that the ACA's expanded eligibility rules were in place during the entire period for all states...
January 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28049440/an-assessment-of-the-level-of-concern-among-hospital-based-health-care-workers-regarding-mers-outbreaks-in-saudi-arabia
#3
Mostafa A Abolfotouh, Ali A AlQarni, Suliman M Al-Ghamdi, Mahmoud Salam, Mohammed H Al-Assiri, Hanan H Balkhy
BACKGROUND: Middle East Respiratory Syndrome (MERS) is caused by MERS coronavirus (MERS-CoV). More than 80% of reported cases have occurred in Saudi Arabia, with a mortality exceeding 50%. Health-care workers (HCWs) are at risk of acquiring and transmitting this virus, so the concerns of HCWs in Saudi Arabia regarding MERS were evaluated. METHODS: An anonymous, self-administered, previously validated questionnaire was given to 1031 HCWs at three tertiary hospitals in Saudi Arabia from October to December, 2014...
January 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28033740/intestinal-malrotation-and-replaced-common-hepatic-artery-during-duodenopancreatectomy-a-case-report
#4
Alexander Schank, Philippe Colonval, Mikhaël Salame
BACKGROUND: Intestinal malrotation is a well-known anomaly in the normal rotation process of the midgut during embryogenesis. Multiple forms are described, resulting in various positional configurations of the small bowel and colon. Replaced common hepatic artery is a rare but not anecdotic variant of the standard hepatic vascularization, associated with surgical implications. Our aim is to explain the impact of their simultaneous presence during this procedure and the difficulty in identifying them preoperatively, despite imaging...
December 29, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28025680/impact-of-surgery-on-quality-of-life-of-women-with-obstetrical-fistula-a-qualitative-study-in-burkina-faso
#5
Julie Désalliers, Marie-Eve Paré, Salam Kouraogo, Jacques Corcos
INTRODUCTION AND HYPOTHESIS: Obstetric fistula, caused by traumatic delivery and patient lack of access to obstetric care, is an important public health concern in developing countries, particularly in Sub-Saharan Africa. This research focuses on the experience of women living with obstetric fistula in Burkina Faso as well as their reintegration into community after surgery. METHODS: This project was funded by the Mères du Monde en Santé (MMS) Foundation and conducted in collaboration with the Boromo Hospital...
December 26, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/28017795/injury-induced-senescence-enables-in%C3%A2-vivo-reprogramming-in-skeletal-muscle
#6
Aurélie Chiche, Isabelle Le Roux, Mathieu von Joest, Hiroshi Sakai, Sabela Búa Aguín, Coralie Cazin, Rana Salam, Laurence Fiette, Olinda Alegria, Patricia Flamant, Shahragim Tajbakhsh, Han Li
In vivo reprogramming is a promising approach for tissue regeneration in response to injury. Several examples of in vivo reprogramming have been reported in a variety of lineages, but some including skeletal muscle have so far proven refractory. Here, we show that acute and chronic injury enables transcription-factor-mediated reprogramming in skeletal muscle. Lineage tracing indicates that this response frequently originates from Pax7+ muscle stem cells. Injury is associated with accumulation of senescent cells, and advanced aging or local irradiation further enhanced in vivo reprogramming, while selective elimination of senescent cells reduced reprogramming efficiency...
December 22, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/28009194/how-bright-is-the-proton-a-precise-determination-of-the-photon-parton-distribution-function
#7
Aneesh Manohar, Paolo Nason, Gavin P Salam, Giulia Zanderighi
It has become apparent in recent years that it is important, notably for a range of physics studies at the Large Hadron Collider, to have accurate knowledge on the distribution of photons in the proton. We show how the photon parton distribution function (PDF) can be determined in a model-independent manner, using electron-proton (ep) scattering data, in effect viewing the ep→e+X process as an electron scattering off the photon field of the proton. To this end, we consider an imaginary, beyond the Standard Model process with a flavor changing photon-lepton vertex...
December 9, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/28004527/efficacy-of-balloon-sinuplasty-in-treatment-of-frontal-rhinosinusitis-a-prospective-study-in-sixty-patients
#8
Philippe F Bowles, Satish Agrawal, Mahmoud A Salam
Balloon dilatation of sinus ostia (sinuplasty) was introduced in 2005 as a treatment for Chronic Rhinosinusitis (CRS).(1) It has been described as a 'transition space' tool for the ethmoidal infundibulum and frontal recess.(1) It can been used as a lone procedure or in combination with functional endoscopic sinus surgery (FESS) as a "hybrid" technique. Balloon sinuplasty applies the Seldinger technique to cannulate and dilate stenosed or occluded sinus ostia re-establishing drainage pathways and ventilation...
December 22, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28000444/diagnosis-and-classification-of-17-diseases-from-1404-subjects-via-pattern-analysis-of-exhaled-molecules
#9
Morad K Nakhleh, Haitham Amal, Raneen Jeries, Yoav Y Broza, Manal Aboud, Alaa Gharra, Hodaya Ivgi, Salam Khatib, Shifaa Badarneh, Lior Har-Shai, Lea Glass-Marmor, Izabella Lejbkowicz, Ariel Miller, Samih Badarny, Raz Winer, John Finberg, Sylvia Cohen-Kaminsky, Frédéric Perros, David Montani, Barbara Girerd, Gilles Garcia, Gérald Simonneau, Farid Nakhoul, Shira Baram, Raed Salim, Marwan Hakim, Maayan Gruber, Ohad Ronen, Tal Marshak, Ilana Doweck, Ofer Nativ, Zaher Bahouth, Da-You Shi, Wei Zhang, Qing-Ling Hua, Yue-Yin Pan, Li Tao, Hu Liu, Amir Karban, Eduard Koifman, Tova Rainis, Roberts Skapars, Armands Sivins, Guntis Ancans, Inta Liepniece-Karele, Ilze Kikuste, Ieva Lasina, Ivars Tolmanis, Douglas Johnson, Stuart Z Millstone, Jennifer Fulton, John W Wells, Larry H Wilf, Marc Humbert, Marcis Leja, Nir Peled, Hossam Haick
We report on an artificially intelligent nanoarray based on molecularly modified gold nanoparticles and a random network of single-walled carbon nanotubes for noninvasive diagnosis and classification of a number of diseases from exhaled breath. The performance of this artificially intelligent nanoarray was clinically assessed on breath samples collected from 1404 subjects having one of 17 different disease conditions included in the study or having no evidence of any disease (healthy controls). Blind experiments showed that 86% accuracy could be achieved with the artificially intelligent nanoarray, allowing both detection and discrimination between the different disease conditions examined...
December 21, 2016: ACS Nano
https://www.readbyqxmd.com/read/27999986/post-treatment-changes-of-tumour-perfusion-parameters-can-help-to-predict-survival-in-patients-with-high-grade-astrocytoma
#10
Roberto Sanz-Requena, Antonio J Revert-Ventura, Gracián García-Martí, Fares Salamé-Gamarra, Alexandre Pérez-Girbés, Enrique Mollá-Olmos, Luis Martí-Bonmatí
OBJECTIVES: Vascular characteristics of tumour and peritumoral volumes of high-grade gliomas change with treatment. This work evaluates the variations of T2*-weighted perfusion parameters as overall survival (OS) predictors. METHODS: Forty-five patients with histologically confirmed high-grade astrocytoma (8 grade III and 37 grade IV) were included. All patients underwent pre- and post-treatment T2*-weighted contrast-enhanced magnetic resonance (MR) imaging. Tumour, peritumoral and control volumes were segmented...
December 20, 2016: European Radiology
https://www.readbyqxmd.com/read/27995624/diagnosing-liver-fibrosis-a-narrative-review-of-current-literature-for-dermatologists
#11
REVIEW
J R Potts, C M Maybury, A Salam, J N Barker, K Agarwal, C H Smith
Chronic liver disease is a growing problem worldwide due to obesity, alcohol-related liver disease and viral hepatitis. Liver fibrosis is generally asymptomatic and patients may not present until they have advanced cirrhosis, when the scope for reversibility is limited. Identification of asymptomatic individuals at an early stage, is fundamental to reversing the rising toll of liver-related morbidity and mortality. Awareness of liver disease and the techniques for diagnosis is important for dermatologists, not only due to the burden of disease in the general population but also because some dermatology cohorts may have an elevated risk; for example the increased prevalence of metabolic syndrome and excess alcohol use in those with psoriasis and hidradenitis suppurativa, in addition to the use of potentially hepatotoxic drugs such as methotrexate...
December 20, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27994630/corrigendum-to-use-of-ethnomedicinal-plants-by-the-people-living-around-indus-river
#12
Sakina Mussarat, Naser M AbdEl-Salam, Akash Tariq, Sultan Mehmood Wazir, Riaz Ullah, Muhammad Adnan
[This corrects the article DOI: 10.1155/2014/212634.].
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27992946/balloon-tuboplasty-in-patients-with-eustachian-tube-dysfunction-a-prospective-study-in-39-patients-55-ears
#13
P F Bowles, S Agrawal, M A Salam
No abstract text is available yet for this article.
December 19, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27984734/dissecting-immune-circuits-by-linking-crispr-pooled-screens-with-single-cell-rna-seq
#14
Diego Adhemar Jaitin, Assaf Weiner, Ido Yofe, David Lara-Astiaso, Hadas Keren-Shaul, Eyal David, Tomer Meir Salame, Amos Tanay, Alexander van Oudenaarden, Ido Amit
In multicellular organisms, dedicated regulatory circuits control cell type diversity and responses. The crosstalk and redundancies within these circuits and substantial cellular heterogeneity pose a major research challenge. Here, we present CRISP-seq, an integrated method for massively parallel single-cell RNA sequencing (RNA-seq) and clustered regularly interspaced short palindromic repeats (CRISPR)-pooled screens. We show that profiling the genomic perturbation and transcriptome in the same cell enables us to simultaneously elucidate the function of multiple factors and their interactions...
December 15, 2016: Cell
https://www.readbyqxmd.com/read/27983993/lentiviral-vector-driven-inhibition-of-5-ht-synthesis-in-b3-bulbo-spinal-serotonergic-projections-consequences-on-nociception-inflammatory-and-neuropathic-pain-in-rats
#15
Anne Gautier, Hanady El Ouaraki, Natacha Bazin, Soha Salam, Guilan Vodjdani, Sylvie Bourgoin, Sophie Pezet, Jean-François Bernard, Michel Hamon
Although it is well established that bulbo-spinal serotonergic projections contribute to pain control mechanisms, whether they exert anti- or pro-nociceptive modulations is still a matter of debate. In order to reappraise the role of 5-HT in descending controls, we used RNA interference to selectively inhibit 5-HT synthesis in B3 neurons and assess resulting changes in nociception. Rats were injected into the bulbar B3 group with a recombinant lentiviral vector, LV-shTPH2, encoding RNA interfering with tryptophan hydroxylase 2 expression...
February 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27979497/societal-norms-and-conditions-and-their-influence-on-daily-life-in-children-with-type-1-diabetes-in-the-west-bank-in-palestine
#16
Kawther Elissa, Ewa-Lena Bratt, Åsa B Axelsson, Salam Khatib, Carina Sparud-Lundin
PURPOSE: To explore the experiences of daily life in children with type 1 diabetes (T1D) and their parents living in the West Bank in Palestine. DESIGN AND METHODS: A qualitative study using thematic interviews was performed with 10 children with T1D and their parents (n=10). Content analysis was performed with the assistance of NVIVO 10. RESULTS: The overall theme was facing the social reality of diabetes. This was underpinned by two themes: stigmatization and social constraints...
December 13, 2016: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/27955746/novel-neuroprotective-and-hepatoprotective-effects-of-citric-acid-in-acute-malathion-intoxication
#17
Omar M E Abdel-Salam, Eman R Youness, Nadia A Mohammed, Noha N Yassen, Yasser A Khadrawy, Safinaz Ebrahim El-Toukhy, Amany A Sleem
OBJECTIVE: To study the effect of citric acid given alone or combined with atropine on brain oxidative stress, neuronal injury, liver damage, and DNA damage of peripheral blood lymphocytes induced in the rat by acute malathion exposure. METHODS: Rats were received intraperitoneal (i.p.) injection of malathion 150 mg/kg along with citric acid (200 or 400 mg/kg, orally), atropine (1 mg/kg, i.p.) or citric acid 200 mg/kg + atropine 1 mg/kg and euthanized 4 h later...
December 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27940964/chronic-exposure-to-water-pipe-smoke-induces-cardiovascular-dysfunction-in-mice
#18
Abderrahim Nemmar, Suhail Al-Salam, Priya Yuvaraju, Sumaya Beegam, Javed Yasin, Badreldin H Ali
Water-pipe tobacco smoking is becoming prevalent in all over the world including Western countries. There are limited data on the cardiovascular effects of water-pipe smoke (WPS), in particular following chronic exposure. Here, we assessed the chronic cardiovascular effects of nose-only WPS exposure in C57BL/6 mice. The duration of the session was 30 min/day, 5 days/week for six consecutive months. Control mice were exposed to air. WPS significantly increased systolic blood pressure. The relative heart weight and plasma concentrations of troponin-I and B-type natriuretic peptide were increased in mice exposed to WPS...
December 9, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27940950/a-gc-rich-sequence-feature-in-the-3-utr-directs-upf1-dependent-mrna-decay-in-mammalian-cells
#19
Naoto Imamachi, Kazi Abdus Salam, Yutaka Suzuki, Nobuyoshi Akimitsu
Up-frameshift protein 1 (UPF1) is an ATP-dependent RNA helicase that has essential roles in RNA surveillance and in post-transcriptional gene regulation by promoting the degradation of mRNAs. Previous studies revealed that UPF1 is associated with the 3' untranslated region (UTR) of target mRNAs via as-yet-unknown sequence features. Herein, we aimed to identify characteristic sequence features of UPF1 targets. We identified 246 UPF1 targets by measuring RNA stabilization upon UPF1 depletion and by identifying mRNAs that associate with UPF1...
December 9, 2016: Genome Research
https://www.readbyqxmd.com/read/27932061/-rare-cause-of-nasal-obstruction-in-infants-rhinopharyngeal-teratoma
#20
L Bahbah, K Chbani, Z Baroudi, S Salam, H Elmahfoudi, L Ouzidane
No abstract text is available yet for this article.
January 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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