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https://www.readbyqxmd.com/read/28427368/complications-of-miliary-tuberculosis-low-mortality-and-predictive-biomarkers-from-a-uk-cohort
#1
Jonathan Underwood, Fiona Cresswell, Alex P Salam, Alex J Keeley, Charles Cleland, Laurence John, Robert N Davidson
BACKGROUND: Untreated, miliary tuberculosis (TB) has a mortality approaching 100%. As it is uncommon there is little specific data to guide its management. We report detailed data from a UK cohort of patients with miliary tuberculosis and the associations and predictive ability of admission blood tests with clinical outcomes. METHODS: Routinely collected demographic, clinical, blood, imaging, histopathological and microbiological data were assessed for all patients with miliary TB identified from the London TB register from 2008 to 2012 from Northwest London Hospitals NHS Trust...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28416764/a-recombinant-fungal-compound-induces-anti-proliferative-and-pro-apoptotic-effects-on-colon-cancer-cells
#2
Lili Nimri, Orly Spivak, Dana Tal, Dominik Schälling, Irena Peri, Lutz Graeve, Tomer M Salame, Oded Yarden, Yitzhak Hadar, Betty Schwartz
Finding intracellular pathways and molecules that can prevent the proliferation of colon cancer cells can provide significant bases for developing treatments for this disease. Ostreolysin (Oly) is a protein found in the mushroom Pleurotus ostreatus, and we have produced a recombinant version of this protein (rOly).We measured the viability of several colon cancer cells treated with rOly. Xenografts and syngeneic colon cancer cells were injected into in vivo mouse models, which were then treated with this recombinant protein...
March 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409762/readmission-for-neonatal-hyperbilirubinemia-in-an-area-with-a-high-prevalence-of-glucose-6-phosphate-dehydrogenase-deficiency-a-hospital-based-retrospective-study
#3
A M Al-Omran, S Y Al-Abdi, Z S Al-Salam
BACKGROUND: Hyperbilirubinemia is one of the most common causes of neonatal readmission to hospital. AIMS: To assess risk factors for hyperbilirubinemia among neonates readmitted for this condition and the ratio of the mean corpuscular hemoglobin concentration (MCHC) to the mean corpuscular volume (MCV). METHODS: We retrospectively studied the clinical and laboratory findings, management and possible risk factors for hyperbilirubinemia in 301 neonates born at ≥35 weeks gestation and readmitted to hospital owing to hyperbilirubinemia over five years...
April 8, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28409051/revisiting-hemicraniectomy-late-decompressive-hemicraniectomy-for-malignant-middle-cerebral-artery-stroke-and-the-role-of-infarct-growth-rate
#4
Saadat Kamran, Naveed Akhtar, Abdul Salam, Ayman Alboudi, Kainat Kamran, Arsalan Ahmed, Rabia A Khan, Mohsin K Mirza, Jihad Inshasi, Ashfaq Shuaib
Objective and Methods. The outcome in late decompressive hemicraniectomy in malignant middle cerebral artery stroke and the optimal timings of surgery has not been addressed by the randomized trials and pooled analysis. Retrospective, multicenter, cross-sectional study to measure outcome following DHC under 48 or over 48 hours using the modified Rankin scale [mRS] and dichotomized as favorable ≤4 or unfavorable >4 at three months. Results. In total, 137 patients underwent DHC. Functional outcome analyzed as mRS 0-4 versus mRS 5-6 showed no difference in this split between early and late operated on patients [P = 0...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28408108/busulfan-drug-monitoring-is-needed-in-patients-undergoing-allogeneic-stem-cell-transplantation
#5
Bushra Salman, Mohammed Al-Zaabi, Mohammed Al-Huneini, David Dennison, Abdulhakeem Al-Rawas, Salam Al-Kindi, Khalil Al-Farsi, Melanie Tauro, Murtadha Al-Khabori
Busulfan (Bu)-based preparative regimens in hematopoietic stem cell transplantation are commonly used. Previous studies have shown that Bu at a fixed dose of 3.2mg/kg/day (FBD) given intravenously decreases variability in drug pharmacokinetics and this decreases the dependency on therapeutic drug monitoring (TDM) of Bu. We compared the Bu dose given using TDM with the FBD of 3.2mg/kg/day. Seventy-three patients with acute leukemia, myelodysplasia, chronic myeloid leukemia, thalassemia major, and sickle cell disease were included...
April 6, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28406118/recent-advances-in-the-management-of-renal-cell-carcinoma-a-radiation-oncology-perspective
#6
REVIEW
A A Abdus-Salam, A A Olabumuyi, M A Jimoh
Renal cell carcinoma (RCC) is a rare cancer in developing countries like Nigeria. However, with an increasing understanding of its epidemiology, the increasing availability of trained personnel, improvement in diagnostic facilities, and greater awareness in the populace, an increase in its incidence as was witnessed in developed nations in the last few decades could be safely predicted. This narrative review highlights the international best practices in the multidisciplinary approach to the management of RCC, its diagnosis and treatment, with emphasis on recent advances and radiation treatment...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28405694/levels-of-organotin-compounds-in-selected-fish-species-from-the-arabian-gulf
#7
Muhammad Waqar Ashraf, Abdus Salam, Atiq Mian
In the present work, data on the levels of hazardous Organotin compounds in eight commercially important fish species, caught from Arabian Gulf, has been reported. Highest levels of tributyltin (TBT) (98.5 ng/g dry weight) were detected in Epinephelus Tauvina whereas minimum (43.7 ng/g) were found in Acanthoparagus Bifasciatus. Highest levels of triphenyltin (TPT) were detected in Lethrinus Miniatus (107.5 ng/g) whereas lowest were encountered in Acanthoparagus Bifasciatus (64.9 ng/g). Highest value of total butyltin compounds (∑BT) were found in emperors (Lethrinus Miniatus) (228...
April 12, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28395021/tipifarnib-prevents-development-of-hypoxia-induced-pulmonary-hypertension
#8
Lucie Duluc, Blerina Ahmetaj-Shala, Jane Mitchell, Vahitha B Abdul-Salam, Abdul S Mahomed, Lulwah Aldabbous, Eduardo Oliver, Lucio Iannone, Olivier D Dubois, Elisabeth M Storck, Edward W Tate, Lan Zhao, Martin R Wilkins, Beata Wojciak-Stothard
Aims: RhoB plays a key role in the pathogenesis of hypoxia-induced pulmonary hypertension. Farnesylated RhoB promotes growth responses in cancer cells and we investigated whether inhibition of protein farnesylation will have a protective effect. Methods and results: The analysis of lung tissues from rodent models and pulmonary hypertensive patients showed increased levels of protein farnesylation. Oral farnesyltransferase inhibitor tipifarnib prevented development of hypoxia-induced pulmonary hypertension in mice...
March 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28393681/characterization-of-bacterial-community-structure-in-a-hydrocarbon-contaminated-tropical-african-soil
#9
Lateef B Salam, Mathew O Ilori, Olukayode O Amund, Yee LiiMien, Hideaki Nojiri
Bacterial community structure in a hydrocarbon-contaminated Mechanical Engineering Workshop (MWO) soil was deciphered using 16S rRNA gene clone library analysis. Four hundred and thirty seven clones cutting across thirteen bacterial phyla were recovered from the soil. The representative bacterial phyla identified from MWO soil are Proteobacteria, Bacteroidetes, Chloroflexi, Acidobacteria, Firmicutes, Actinobacteria, Verrucomicrobia, Planctomycetes, Ignavibacteriae, Spirochaetes, Chlamydiae, Candidatus Saccharibacteria and Parcubacteria...
April 10, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28393618/regulatory-b-cells-are-functionally-impaired-in-patients-having-hemophilia-a-with-inhibitors
#10
Mohamed-Rachid Boulassel, Maryam Al-Ghonimi, Badriya Al-Balushi, Amal Al-Naamani, Zahra Al-Qarni, Yasser Wali, Mohamed Elshinawy, Maryam Al-Shezawi, Hamad Khan, Hanan Nazir, Doaa Khater, Anil Pathare, Salam Al-Kindi
Development of inhibitors remains a major clinical complication in patients with hemophilia A receiving replacement therapy with factor VIII (FVIII). Understanding the immune mechanisms involved in the development of inhibitors can provide valuable information about pathways to human tolerance. Recent evidence indicates that B regulatory (Breg) cells play a pivotal role in controlling the production of antibodies (Abs) while promoting follicular T helper (Tfh) cells and monocytes, expressing the low-density lipoprotein receptor-related protein (LRP/CD91), which is involved in FVIII intake from the circulation...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28387156/mpk9-and-mpk12-function-in-sa-induced-stomatal-closure-in-arabidopsis-thaliana
#11
Md Atiqur Rahman Khokon, Mohammad Abdus Salam, Fabien Jammes, Wenxiu Ye, Mohammad Anowar Hossain, Eiji Okuma, Yoshimasa Nakamura, Izumi C Mori, June M Kwak, Yoshiyuki Murata
Salicylic acid (SA) induces stomatal closure sharing several components with abscisic acid (ABA) and methyl jasmonate (MeJA) signaling. We have previously shown that two guard cell-preferential mitogen-activated protein kinases (MAPKs), MPK9 and MPK12, positively regulate ABA signaling and MeJA signaling in Arabidopsis thaliana. In this study, we examined whether these two MAPKs are involved in SA-induced stomatal closure using genetic mutants and a pharmacological, MAPKK inhibitor. Salicylic acid induced stomatal closure in mpk9 and mpk12 single mutants but not in mpk9 mpk12 double mutants...
April 7, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28387126/gender-variations-in-in-hospital-mortality-in-patients-hospitalized-with-dizziness-a-retrospective-study
#12
Amar M Salam, Hajar A AlBinali, Rajvir Singh, Awad Al-Qahtani, Nidal Asaad, Jassim Al Suwaidi
Women with cardiac diseases generally have a higher mortality than men. Suggested reasons include delay in reporting to hospital, less aggressive management, and higher cardiovascular risk profiles in women. We assessed gender differences in patients hospitalized with dizziness. We retrospectively reviewed the database of patients hospitalized with acute cardiac disease in Qatar from 1991 to the end of 2010. Patients hospitalized with dizziness were analyzed; 1611 (3.8%; 95% confidence interval [CI]: 3.6%-4%) of the total N = 42 144 patients were hospitalized with dizziness during the 20 years: 410 (25...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28379273/effect-of-nucleants-in-photothermally-assisted-crystallization
#13
T Shilpa, Sajan D George, Aseefhali Bankapur, Santhosh Chidangil, Aditya K Dharmadhikari, Deepak Mathur, S Madan Kumar, K Byrappa, Abdul Ajees Abdul Salam
Laser-induced crystallization is emerging as a promising technique to crystallize biomolecules like amino acids and proteins. The use of external materials as nucleants and novel seeding methods open new paths for protein crystallization. We report here the results of experiments that explore the effect of nucleants on laser-based crystallization of microlitre droplets of small molecules, amino acids, and proteins. The role of parameters like solute concentration, droplet volume, type and size of the nucleant, and laser power, are systematically investigated...
April 5, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28375126/tyrosinase-inhibition-anti-acetylcholinesterase-and-antimicrobial-activities-of-the-phytochemicals-from-gynotroches-axillaris-blume
#14
Salam Ahmed Abed, Hasnah Mohd Sirat, Muhammad Taher
The leaves of Gynotroches axillaris were chemically and biologically studied. Sequential extraction of the leaves using petroleum ether, chloroform, and methanol afforded three extracts. Purification of pet. ether extract yielded, squalene and β-amyrin palmitate as the major compounds, together with palmitic acid and myristic acid as the minor components. The methanol extract yielded two flavonoids, quercitrin and epicatechin. The isolated compounds were characterized by MS, IR and NMR (1D and 2D). Anti-acetyl cholinesterase screening using TLC bio-autography assay showed that palmitic acid and myristic acid were the strongest inhibition with detection limit 1...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28372248/validation-of-quechers-based-method-for-determination-of-fenitrothion-residues-in-tomatoes-by-gas-chromatography-flame-photometric-detector-decline-pattern-and-risk-assessment
#15
Farag Malhat, Julien Boulangé, Ehab Abdelraheem, Osama Abd Allah, Rania Abd El-Hamid, Shokr Abd El-Salam
A simple and rapid gas chromatography with flame photometric detector (GC-FPD) determination method was developed to detect residue levels and investigate the dissipation pattern and safe use of fenitrothion in tomatoes. A modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) using an ethyl acetate-based extraction, followed by a dispersive solid-phase extraction (d-SPE) with primary-secondary amine (PSA) and graphite carbon black (GCB) for clean up, was applied prior to GC-FPD analysis. The method showed satisfactory linearity, recovery and precision...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28367013/motor-vehicle-accidents-the-physical-versus-the-psychological-trauma
#16
Mahmoud M Salam
No abstract text is available yet for this article.
April 2017: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/28366721/neuroprotective-role-of-ginkgo-biloba-against-cognitive-deficits-associated-with-bisphenol-a-exposure-an-animal-model-study
#17
Manar Mohammed El Tabaa, Samia Salem Sokar, Ehab Sayed Ramdan, Inas Zakria Abd El Salam, Anis Zaid
Our study aimed to elucidate to what extent Ginkgo biloba (Gb) can protect rats from cognitive deficits induced by exposure to Bisphenol A (BPA) at high dose. Therefore, sixty male Wistar rats were randomly divided into four groups of 15 animals in each group: Vehicle group, Gb-control group, BPA-exposed group and Gb pre-treated group. All administrations were given daily by an oral gavage once a day for eight weeks. Cognitive function was assessed using Morris water maze; Y-maze and Novel object recognition tasks...
March 30, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28359140/gold-nanoparticles-as-a-direct-and-rapid-sensor-for-sensitive-analytical-detection-of-biogenic-amines
#18
K M A El-Nour, E T A Salam, H M Soliman, A S Orabi
A new optical sensor was developed for rapid screening with high sensitivity for the existence of biogenic amines (BAs) in poultry meat samples. Gold nanoparticles (GNPs) with particle size 11-19 nm function as a fast and sensitive biosensor for detection of histamine resulting from bacterial decarboxylation of histidine as a spoilage marker for stored poultry meat. Upon reaction with histamine, the red color of the GNPs converted into deep blue. The appearance of blue color favorably coincides with the concentration of BAs that can induce symptoms of poisoning...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28357173/status-epilepticus-and-blindness-in-a-patient-with-carfilzomib-associated-posterior-reversible-encephalopathy-syndrome
#19
Salam Kadhem, Rawaa Ebrahem, Scott Cooper, Emily Manlove, Ricky Lee
Posterior reversible encephalopathy syndrome (PRES) is a neurological condition characterized by headaches, visual disturbances, and seizures. A magnetic resonance imaging (MRI) scan of an affected brain typically shows symmetrical white matter edema in the posterior cerebral hemispheres. The onset of PRES can constitute a medical emergency, especially when accompanied by status epilepticus. If promptly recognized and treated, the clinical syndrome and associated radiological findings are usually resolved in a matter of weeks or months...
February 19, 2017: Curēus
https://www.readbyqxmd.com/read/28346519/views-of-senior-health-personnel-about-quality-of-emergency-obstetric-care-a-qualitative-study-in-nigeria
#20
Friday Okonofua, Abdullahi Randawa, Rosemary Ogu, Kingsley Agholor, Ola Okike, Rukayat Adeola Abdus-Salam, Mohammed Gana, Eghe Abe, Adetoye Durodola, Hadiza Galadanci
BACKGROUND: Late arrival in hospital by women experiencing pregnancy complications is an important background factor leading to maternal mortality in Nigeria. The use of effective and timely emergency obstetric care determines whether women survive or die, or become near-miss cases. Healthcare managers have the responsibility to deploy resources for implementing emergency obstetric care. OBJECTIVES: To determine the nature of institutional policies and frameworks for managing obstetric complications and reducing maternal deaths in Nigeria...
2017: PloS One
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