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https://www.readbyqxmd.com/read/28319995/clinical-trials-of-therapeutics-for-the-prevention-of-congenital-zika-virus-disease-challenges-and-potential-solutions
#1
Alex P Salam, Amanda Rojek, Jake Dunning, Peter W Horby
Zika virus (ZIKV) infection in pregnancy is associated with adverse fetal outcomes, such as microcephaly and other congenital malformations. No therapeutic options are available to pregnant women with ZIKV infection to prevent these effects. Drug trials in pregnancy raise several scientific, ethical, and logistical challenges, which are compounded further in ZIKV because of limited knowledge of the disease pathophysiology and a product development pipeline in its infancy. We evaluate the major challenges in choosing therapeutics to prevent congenital ZIKV disease and conducting clinical trials of these treatments, with a focus on preventing congenital central nervous system malformations...
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28303625/eradication-rate-of-helicobacter-pylori-infection-is-directly-influenced-by-adherence-to-therapy-in-children
#2
Kallirroi Kotilea, Joyce Mekhael, Assaad Salame, Tania Mahler, Veronique Yvette Miendje-Deyi, Samy Cadranel, Patrick Bontems
BACKGROUND: Current commonly accepted strategies to eradicate Helicobacter pylori in children are a 10-day sequential treatment or a triple therapy for 7-14 days. To avoid further expensive and possibly risky investigations as well as induction of secondary antimicrobial resistance, a success rate of elimination strategies over 90% in a per-protocol analysis is the target goal but rates observed in clinical trials are lower. Antimicrobial resistance is a well-recognized risk factor for treatment failure; therefore, only a treatment tailored to susceptibility testing should be recommended...
March 17, 2017: Helicobacter
https://www.readbyqxmd.com/read/28302182/qualitative-assessment-of-women-s-satisfaction-with-maternal-health-care-in-referral-hospitals-in-nigeria
#3
Friday Okonofua, Rosemary Ogu, Kingsley Agholor, Ola Okike, Rukiyat Abdus-Salam, Mohammed Gana, Abdullahi Randawa, Eghe Abe, Adetoye Durodola, Hadiza Galadanci
BACKGROUND: Available evidence suggests that the low use of antenatal, delivery, and post-natal services by Nigerian women may be due to their perceptions of low quality of care in health facilities. This study investigated the perceptions of women regarding their satisfaction with the maternity services offered in secondary and tertiary hospitals in Nigeria. METHODS: Five focus group discussions (FGDs) were held with women in eight secondary and tertiary hospitals in four of the six geo-political zones of the country...
March 16, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28300600/ethanolic-extracts-of-inula-viscosa-salix-alba-and-quercus-calliprinos-negatively-affect-the-development-of-the-entomopathogenic-nematode-heterorhabditis-bacteriophora-a-model-to-compare-gastro-intestinal-nematodes-developmental-effect
#4
Velayudhan Satheeja Santhi, Liora Salame, Levana Dvash, Hussein Muklada, Hassan Azaizeh, Raghda Mreny, Safaa Awwad, Alex Markovics, Serge Yan Landau, Itamar Glazer
Heterorhabditis bacteriophora can represent a model system for herbal medication against gastro-intestinal strongylid parasites in determining the recovery and development due to their unique parasitic infectious cycle. The fact that plant extracts impair nematode development is known but their differential impact on stages of the life cycle of H. bacteriophora has never been investigated. We examined the developmental stages resumed from eggs, young juveniles (J1-3), infective juveniles (IJs), young and adult hermaphrodites of H...
March 11, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28299320/etiology-of-end-stage-renal-disease-and-arterial-stiffness-among-hemodialysis-patients
#5
Balsam El Ghoul, Yazan Daaboul, Serge Korjian, Andrew El Alam, Anthony Mansour, Essa Hariri, Salam Samad, Pascale Salameh, Georges Dahdah, Jacques Blacher, Michel E Safar, Sola Aoun Bahous
Background. Prior studies have demonstrated that conventional and emerging CV risk factors are associated with worsening arterial stiffness among end-stage renal disease (ESRD) patients on hemodialysis. The present cross-sectional study evaluates the association between the etiology of ESRD and arterial stiffness among a cohort of hemodialysis patients. Methods. Etiology of ESRD was identified from patients' medical records and classified as either vascular renal disease, diabetic nephropathy, nondiabetic glomerulopathy, tubular interstitial nephropathy, hereditary nephropathy, or ESRD of unconfirmed etiology...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28296467/comparison-of-insulin-pump-therapy-and-multiple-daily-injections-insulin-regimen-in-patients-with-type-1-diabetes-during-ramadan-fasting
#6
Reem Alamoudi, Maram Alsubaiee, Ali Alqarni, Yousef Saleh, Saleh Aljaser, Abdul Salam, Mohsen Eledrisi
INTRODUCTION: Fasting Ramadan carries a high risk for patients with type 1 diabetes (T1DM). Data on the optimum insulin regimen in these patients are limited. OBJECTIVES: To compare glucose profiles in patients with T1DM who use continuous subcutaneous insulin infusion (CSII) compared with those who use multiple daily injections (MDI) insulin regimen during Ramadan fast. The primary outcome was rates of hypoglycemia. Other outcomes included glycemic control, number of days needed to break fasting, and acute glycemic complications...
March 15, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28293401/alloimmunization-in-patients-with-sickle-cell-disease-and-thalassemia-experience-of-a-single-centre-in-oman
#7
Salam Alkindi, Saba AlMahrooqi, Sumaiya AlHinai, Ali AlMarhoobi, Saif Al-Hosni, Shahina Daar, Naglaa Fawaz, Anil Pathare
BACKGROUND: Blood transfusion is an integral part of the supportive care for patients with sickle cell disease (SCD) and thalassaemia. The hazard of red cell alloimmunization, however, is one of the main complications of this therapy. OBJECTIVES: The aim of this study was to evaluate the prevalence of red cell alloimmunization in Omani patients with sickle cell anaemia and thalassemia. METHODS: This study included 262 patients whose historical transfusion records were available...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28271163/molecular-characterization-of-neuraminidase-genes-of-influenza-a-h3n2-viruses-circulating-in-southwest-india-from-2009-to-2013
#8
Anitha Jagadesh, Abdul Ajees Abdul Salam, Vahid Rajabali Zadeh, Anjana Krishnan, Govindakarnavar Arunkumar
Molecular characterization of neuraminidase (NA) gene of 25 influenza A(H3N2) virus isolates (2009-2013) archived at the Manipal Centre for Virus Research was carried out. The annual rate of amino acid substitutions in the N2 gene of influenza A(H3N2) virus isolates was 0.2-0.6%. Out of the 25 NA sequences analyzed, catalytic site mutations were observed in three isolates. Two of the mutations (D151G and E276G) were detected in functional catalytic residues, and an E227V mutation was detected in the framework residues...
March 7, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28259469/microbial-enhanced-lindane-removal-by-sugarcane-saccharum-officinarum-in-doped-soil-applications-in-phytoremediation-and-bioaugmentation
#9
Jaseetha Abdul Salam, Mohammed A A Hatha, Nilanjana Das
The aim of this study was to examine the effect of lindane-degrading yeast on the growth and lindane uptake by Saccharum sp., in doped garden soils. The rhizosphere of Saccharum plant was amended with yeast Candida VITJzN04 by root-inoculation. The bio-augment yeast was applied in two different forms viz., planktonic form and cells immobilized on sugarcane-bagasse, in the pot experiments. Garden soils (lindane∼100 mg/kg) exposed to various treatments were monitored for a period of 30 days, for residual lindane by gas-chromatography analysis...
May 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28251418/comparison-between-two-linear-supervised-learning-machines-methods-with-principle-component-based-methods-for-the-spectrofluorimetric-determination-of-agomelatine-and-its-degradants
#10
Mahmoud M Elkhoudary, Ibrahim A Naguib, Randa A Abdel Salam, Ghada M Hadad
Four accurate, sensitive and reliable stability indicating chemometric methods were developed for the quantitative determination of Agomelatine (AGM) whether in pure form or in pharmaceutical formulations. Two supervised learning machines' methods; linear artificial neural networks (PC-linANN) preceded by principle component analysis and linear support vector regression (linSVR), were compared with two principle component based methods; principle component regression (PCR) as well as partial least squares (PLS) for the spectrofluorimetric determination of AGM and its degradants...
March 1, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28250677/assessment-of-changes-in-insulin-requirement-in-patients-of-type-2-diabetes-mellitus-on-maintenance-hemodialysis
#11
M J Sudha, Halma S Salam, S Viveka, A L Udupa
BACKGROUND: Hemodialysis improves insulin sensitivity. Currently, there is no recommendation for the adjustment of insulin dose on dialysis day and nondialysis day in diabetic patients. This study was undertaken to determine the variations in insulin requirement based on blood glucose levels on dialysis days and nondialysis days in type 2 diabetic patients with chronic kidney disease on maintenance hemodialysis. METHODOLOGY: Twenty-eight diabetic patients on hemodialysis were recruited into the study after obtaining written informed consent and approval from Azeezia Ethics Committee...
January 2017: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/28245471/water-pipe-smoke-exposure-induced-circulatory-disturbances-in-mice-and-the-influence-of-betaine-supplementation-thereon
#12
Abderrahim Nemmar, Suhail Al-Salam, Sumaya Beegam, Priya Yuvaraju, Abderrahim Oulhaj, Badreldin H Ali
BACKGROUND/AIMS: It has been shown, both experimentally and clinically, that water-pipe smoke (WPS) exposure adversely affects the cardiovascular system (CVS) through the generation of oxidative stress and inflammation. Betaine, a naturally occurring compound in common foods, has antioxidant and anti-inflammatory actions. However, its potential to mitigate the adverse effect of WPS on the CVS has never been reported before. This is the subject of this study in mice. METHODS: Mice were exposed daily for 30 min to either normal air (control), or to WPS for two consecutive weeks...
February 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28240250/regulation-of-tfpi%C3%AE-expression-by-mir-27a-b-3p-in-human-endothelial-cells-under-normal-conditions-and-in-response-to-androgens
#13
Ana B Arroyo, Salam Salloum-Asfar, Carlos Pérez-Sánchez, Raúl Teruel-Montoya, Silvia Navarro, Nuria García-Barberá, Ginés Luengo-Gil, Vanessa Roldán, John-Bjarne Hansen, Chary López-Pedrera, Vicente Vicente, Rocío González-Conejero, Constantino Martínez
The increased risk of cardiovascular events in older men is multifactorial, but the significant reduction of testosterone levels has been involved. As this hormone regulates the expression of TFPI by unknown mechanisms, we aimed to evaluate the role of miRNAs in the regulation of TFPIα expression under normal conditions and in response to androgens. In silico studies allowed the selection of 4 miRNAs as potential TFPIα regulators. Only miR-27a/b-3p significantly reduced TFPIα expression in two endothelial cell lines...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28235702/design-synthesis-biological-evaluation-and-x-ray-structural-studies-of-potent-human-dihydroorotate-dehydrogenase-inhibitors-based-on-hydroxylated-azole-scaffolds
#14
Stefano Sainas, Agnese C Pippione, Marta Giorgis, Elisa Lupino, Parveen Goyal, Cristina Ramondetti, Barbara Buccinnà, Marco Piccinini, Rodolpho C Braga, Carolina H Andrade, Mikael Andersson, Ann-Christin Moritzer, Rosmarie Friemann, Stefano Mensa, Salam Al-Kadaraghi, Donatella Boschi, Marco L Lolli
A new generation of potent hDHODH inhibitors designed by a scaffold-hopping replacement of the quinolinecarboxylate moiety of brequinar, one of the most potent known hDHODH inhibitors, is presented here. Their general structure is characterized by a biphenyl moiety joined through an amide bridge with an acidic hydroxyazole scaffold (hydroxylated thiadiazole, pyrazole and triazole). Molecular modelling suggested that these structures should adopt a brequinar-like binding mode involving interactions with subsites 1, 2 and 4 of the hDHODH binding site...
March 31, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28231123/antibacterial-and-antioxidant-activities-of-essential-oils-from-artemisia-herba-alba-asso-pelargonium-capitatum-%C3%A3-radens-and-laurus-nobilis-l
#15
Ragina Rafiq, Saeed A Hayek, Ugochukwu Anyanwu, Bonita I Hardy, Valerie L Giddings, Salam A Ibrahim, Reza Tahergorabi, Hye Won Kang
Essential oils are natural antimicrobials that have the potential to provide a safer alternative to synthetic antimicrobials currently used in the food industry. Therefore, the aim of this study was to evaluate the antimicrobial and antioxidant activities of essential oils from white wormwood, rose-scented geranium and bay laurel against Salmonella typhimurium and Escherichia coli O157:H7 on fresh produce and to examine consumer acceptability of fresh produce treated with these essential oils. Our results showed that essential oil derived from rose-scented geranium exhibited the most effective antimicrobial activity at the same and similar minimum inhibition concentration levels (0...
April 11, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28229100/diagnosis-of-tuberculosis-following-world-health-organization-recommended-criteria-in-severely-malnourished-children-presenting-with-pneumonia
#16
Mohammod Jobayer Chisti, Mohammed Abdus Salam, Abu S M S B Shahid, K M Shahunja, Sumon Kumar Das, Abu Syed Golam Faruque, Pradip Kumar Bardhan, Tahmeed Ahmed
Evidences on diagnosis of tuberculosis (TB) following the World Health Organization (WHO) criteria in children with severe acute malnutrition (SAM) are lacking. We sought to evaluate the WHO criteria for the diagnosis of TB in such children. In this prospective study, we enrolled SAM children aged <5 with radiological pneumonia. We collected induced sputum and gastric lavage for smear microscopy, mycobacterial culture, and Xpert MTB/RIF. Using the last 2 methods as the gold standard, we determined sensitivity, specificity, and positive and negative predictive values of WHO criteria (n = 388)...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28219371/erratum-to-camel-milk-peptide-improves-wound-healing-in-diabetic-rats-by-orchestrating-the-redox-status-and-immune-response
#17
Hossam Ebaid, Bahaa Abdel-Salam, Iftekhar Hassan, Jameel Al-Tamimi, Ali Metwalli, Ibrahim Alhazza
No abstract text is available yet for this article.
February 20, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28215918/molecular-detection-of-genes-responsible-for-macrolide-resistance-among-streptococcus-pneumoniae-isolated-in-north-lebanon
#18
Salam El Ashkar, Marwan Osman, Rayane Rafei, Hassan Mallat, Marcel Achkar, Fouad Dabboussi, Monzer Hamze
In recent years, the increased use of macrolides was linked with the emergence of resistance Streptococcus pneumoniae worldwide. The main aim of this study was to determine the prevalence of S. pneumoniae resistant to macrolides and to identify the macrolide resistance genotypes among clinical isolates collected in North Lebanon. Disk diffusion susceptibility method was performed for 132 strains of S. pneumoniae isolated over a period of 5 years in North Lebanon. Polymerase Chain Reaction followed by pyrosequencing was carried out for confirmation of phenotypic diagnosis...
February 16, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28214941/monitoring-water-pollution-levels-in-wadi-hanifa-riyadh-saudi-arabia-and-its-public-health-implications
#19
Bushra Ahmed Al-Hammad, Magda Magdy Abd El-Salam
This study was performed to evaluate the levels of metals in the fish caught from Wadi Hanifa's main basin over four seasons, determine the potential fitness of the fish for human consumption, and evaluate the overall water quality after enforcement of local standards. The physical and chemical parameters from a total of 192 water samples were tested using standard methods. Additionally, a total of 48 fish samples were analyzed for heavy metal concentrations. Mean values for basic water quality parameters of COD, PO4(-3), NH3(-)-N, and NO3(-)-N exceeded Saudi standards in all seasons...
April 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28214187/microbiological-analysis-antimicrobial-activity-and-heavy-metals-content-of-jordanian-ma-in-hot-springs-water
#20
Muhamad Ali K Shakhatreh, Jacob H Jacob, Emad I Hussein, Majed M Masadeh, Safwan M Obeidat, Abdul-Salam F Juhmani, Mutaz A Abd Al-Razaq
Ma'in hot springs are known as sites of balneotherapy. However, little is known about their microbiology and chemistry. In this study, we aim at evaluating the antimicrobial activity of Ma'in hot-springs water (MHSW), studying its microbiology, and determining its physicochemical properties including the heavy metals content. Therefore, water samples were collected from Ma'in hot springs and tested for antimicrobial activity using agar diffusion method. Water was then cultivated on nutrient agar to isolate and identify the dominant bacteria by chemical and molecular methods...
February 14, 2017: Journal of Infection and Public Health
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