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https://www.readbyqxmd.com/read/29343958/preparation-of-anastrozole-loaded-peg-pla-nanoparticles-evaluation-of-apoptotic-response-of-breast-cancer-cell-lines
#1
Yusra A Alyafee, Manal Alaamery, Shahad Bawazeer, Mansour S Almutairi, Badr Alghamdi, Nawaf Alomran, Atia Sheereen, Maha Daghestani, Salam Massadeh
Purpose: Anastrozole (ANS) is an aromatase inhibitor that is widely used as a treatment for breast cancer in postmenopausal women. Despite the wide use of ANS, it is associated with serious side effects due to uncontrolled delivery. In addition, ANS exhibits low solubility and short plasma half-life. Nanotechnology-based drug delivery has the potential to enhance the efficacy of drugs and overcome undesirable side effects. In this study, we aimed to prepare novel ANS-loaded PLA-PEG-PLA nanoparticles (ANS-NPs) and to compare the apoptotic response of MCF-7 cell line to both ANS and ANS-loaded NPs...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29337401/rhabdomyolysis-after-co-administration-of-a-statin-and-fusidic-acid-an-analysis-of-the-literature-and-of-the-who-database-of-adverse-drug-reactions
#2
T Deljehier, A Pariente, G Miremont-Salamé, F Haramburu, L Nguyen, S Rubin, C Rigothier, H Théophile
Following a severe case of rhabdomyolysis in our University Hospital after a co-administration of atorvastatin and fusidic acid, we describe this interaction as this combination is not clearly contraindicated in some countries, particularly for long-term treatment by fusidic acid. All cases of rhabdomyolysis during a co-administration of a statin and fusidic acid were identified in the literature and in the World and Health Organization database, VigiBase®. In the literature, 29 cases of rhabdomyolysis were identified; mean age was 66 years, median duration of co-administration before rhabdomyolysis occurrence was 21 days, 28% of cases were fatal...
January 16, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29332193/melanogenesis-inhibitory-activity-of-components-from-salam-leaf-syzygium-polyanthum-extract
#3
Andriyana Setyawati, Kae Hirabayashi, Kosei Yamauchi, Hiroyuki Hattori, Tohru Mitsunaga, Irmanida Batubara, Rudi Heryanto, Hiroshi Hashimoto, Mitsuyuki Hotta
In order to identify a novel whitening agent, the methanol extract of S. polyanthum leaf was focused on by the screening test using nine Indonesian medicinal plants for the inhibition of melanogenesis and tyrosinase activity in B16 melanoma cells. Three novel compounds [(1) 1-(2,3,5-trihydroxy-4-methylphenyl)hexane-1-one, (2) 1-(2,3,5-trihydroxy methylphenyl)octane-1-one, and (3) (4E)-1-(2,3,5-trihydroxy-4-methylphenyl)decan-1-one and one known compound [(4) 1-(2,3,5-trihydroxy-4-methylphenyl)decan-1-one were isolated from the methanol extract...
January 13, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29331191/-an-innovative-teleconsultation-project-in-liver-transplantation
#4
REVIEW
Ephrem Salamé, Dominique Lepagnot, Isabelle Goujon
The Tours and Bourges hospital teams have developed innovative collaborative practices in the monitoring of patients having received a liver transplant. Teleconsultation helps the patient resume their normal life by enabling them to avoid tiring and time-consuming appointments.
January 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29330712/correction-to-pre-existing-small-vessel-disease-in-patients-with-acute-stroke-from-the-middle-east-southeast-asia-and-philippines
#5
Naveed Akhtar, Abdul Salam, Saadat Kamran, Atlantic D'Souza, Yahia Imam, Pablo Garcia Bermejo, Muhammad Faisal Wadiwala, Ahmed Own, Ahmed ElSotouhy, Surjith Vattoth, Paula Bourke, Zain Bhutta, Sujatha Joseph, Mark Santos, Rabia Ali Khan, Ashfaq Shuaib
The author names "Dr. Pablo Garcia Bermejo" and "Dr. Muhammad Faisal Wadiwala" needed to be added as the 6th and 7th authors, respectively. The authors regret this error.
January 13, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29316259/fatal-outcome-after-reactivation-of-inherited-chromosomally-integrated-hhv-6a-icihhv-6a-transmitted-through-liver-transplantation
#6
P Bonnafous, J Marlet, D Bouvet, E Salamé, A-C Tellier, S Guyetant, A Goudeau, H Agut, A Gautheret-Dejean, C Gaudy-Graffin
HHV-6A and HHV-6B are found as inherited and chromosomally integrated forms (iciHHV-6A and -6B) into all germinal and somatic cells and vertically transmitted in a Mendelian manner in about 1% of the population. They were occasionally shown to be horizontally transmitted through hematopoietic stem cell transplantation. Here, we present a clinical case of horizontal transmission of iciHHV-6A from donor to recipient through liver transplantation. Molecular analysis performed on three viral genes (7.2 kb) in the recipient and donor samples supports transmission of iciHHV-6A from the graft...
January 9, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29298235/recipient-selection-for-optimal-utilization-of-discarded-grafts-in-liver-transplantation
#7
Giovanni Giretti, Louise Barbier, Petru Bucur, Frédéric Marques, Jean-Marc Perarnau, Martine Ferrandière, Anne-Charlotte Tellier, Vincent Kerouredan, Mario Altieri, Xavier Causse, Maryline Debette-Gratien, Christine Silvain, Ephrem Salamé
BACKGROUND: In France, liver grafts that have been refused by at least 5 teams are considered for rescue allocation, with the choice of the recipient being at the team's discretion. While this system permits the use of otherwise discarded grafts in a context of organ shortage, outcomes and potential benefits need to be assessed. METHODS: Between 2011 and 2015, outcomes of rescue allocation grafts (n=33) were compared to standard allocation grafts (n=321) at a single French center...
January 2, 2018: Transplantation
https://www.readbyqxmd.com/read/29298127/association-between-loss-of-type-iv-pilus-synthesis-ability-and-phenotypic-variation-in-the-cucurbit-pathogenic-bacterium-acidovorax-citrulli
#8
Tally Rosenberg, Bolaji Babajide Salam, Saul Burdman
Acidovorax citrulli is the causal agent of bacterial fruit blotch of cucurbits. We have shown that functional type IV pili (T4P) are required for full virulence of this bacterium. To identify A. citrulli genes required for T4P activity, we screened a library of about 10,000 transposon mutants of A. citrulli strain M6 for altered T4P-mediated twitching motility. This screen led to the identification of 50 mutants impaired in twitching ability due to transposon insertions into 20 different genes. Representative mutants with disruptions in these genes were further characterized...
January 3, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29288361/genome-sequence-and-comparative-analysis-of-jiangella-alba-yim-61503t-isolated-from-a-medicinal-plant-maytenus-austroyunnanensis
#9
Jian-Yu Jiao, Nimaichand Salam, Lan Liu, Manik Prabhu Narsing Rao, Xiao-Tong Zhang, Bao-Zhu Fang, Ming-Xian Han, Zi-Tong Zhang, Jing Chen, Jiao Zhao, Yu Zhou, Dalal Hussien M Alkhalifah, Qing Liu, Min Xiao, Hans-Peter Klenk, Wen-Jun Li
A draft genome sequence of Jiangella alba YIM 61503T revealed a genome size of 7,664,864 bp arranged in 33 scaffolds. The genome was predicted to contain 7196 predicted genes, including 51 coding for RNA. Phylogenetic and comparative analyses of the draft genome of J. alba YIM 61503T with the available genomes of other Jiangella species suggested a proximal similarity between strains J. alba YIM 61503T and J. muralis DSM 45357T, while indicating a high divergence between J. gansuensis YIM 002T and other Jiangella species...
December 29, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29283095/evaluation-of-cervical-vestibular-evoked-myogenic-potential-in-subjects-with-chronic-noise-exposure
#10
Nehal Mamdouh Abd El Salam, Elshahat Ibrahem Ismail, Ayman El Saeed El Sharabasy
OBJECTIVE: Noise has been recognized as a major cause of cochlear damage resulting in both tinnitus and hearing loss. On the other hand, damage to the vestibular system, especially the saccule, can be considered as a potential problem. The cervical vestibular-evoked myogenic potentials (cVEMPs) have been established as a clinical test of measuring both sac-cular and inferior vestibular nerve function. Therefore, it is thought to be sensitive to the noise-induced damage to the vestibular system...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29281090/novel-reagents-for-human-prolactin-research-large-scale-preparation-and-characterization-of-prolactin-receptor-extracellular-domain-non-pegylated-and-pegylated-prolactin-and-prolactin-receptor-antagonist
#11
Ewa Oclon, Gili Solomon, Zvi Hayouka, Tomer Meir Salame, Vincent Goffin, Arieh Gertler
To provide new tools for in vitro and in vivo prolactin (PRL) research, novel protocols for large-scale preparation of untagged human PRL (hPRL), a hPRL antagonist (del 1-9-G129R hPRL) that acts as a pure antagonist of hPRL in binding to hPRL receptor extracellular domain (hPRLR-ECD), and hPRLR-ECD are demonstrated. The interaction of del 1-9-G129R hPRL with hPRLR-ECD was demonstrated by competitive non-radioactive binding assay using biotinylated hPRL as the ligand and hPRLR-ECD as the receptor, by formation of stable 1:1 complexes with hPRLR-ECD under non-denaturing conditions using size-exclusion chromatography, and by surface plasmon resonance methodology...
December 21, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/29279091/molecular-genotyping-of-echinococcus-granulosus-in-the-north-of-iraq
#12
Salam Jumaah Hammad, Serena Cavallero, Giovanni Luigi Milardi, Simona Gabrielli, Stefano D Amelio, Fatima Shihab Al-Nasiri
Cystic echinococcosis/hydatidosis is an important cosmopolitan zoonotic disease that causes large economic losses and human suffering. The larval stages of Echinococcus granulosus are the etiological agents of cystic echinococcosis that showed different genotypes in different regions in the world. The present study was aimed at the detection of E. granulosus strains circulating in two cities from north of Iraq (Kirkuk and Sulaimania). A total of 47 specimens of hydatid cysts were collected from patients and from different domestic intermediate hosts including cattle, sheep, goat and buffalo from slaughterhouses...
January 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29274208/the-light-microscopy-and-ultrastructural-characteristics-of-myxobolus-naffari-myxosporea-myxobolidae-infecting-the-nile-carp-labeo-niloticus-cyprinidae-and-its-histological-impact
#13
Naksheen M Ardalan, Salam F Al-Hashimi, Manal El Garhy, Salwa AH Hamdi, Ali Al Ghamdi, Kareem Morsy
During a survey of myxosporean parasites infecting freshwater fishes from the River Nile at Giza Governorates, Egypt between March and September 2016, nine out of 30 specimens of the Nile carp Labeo niloticus (Cyprinidae) were found to be naturally infected with Myxobolus naffari (Myxobolidae). Small macroscopic plasmodia appeared embedded in the host gill tissue accompanied with fusion of the gill epithelia, and atrophy was observed at the site of infection. The host reaction was manifested by the encapsulation of the plasmodia with a thick layer of connective tissue...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/29273806/multiancestry-association-study-identifies-new-asthma-risk-loci-that-colocalize-with-immune-cell-enhancer-marks
#14
Florence Demenais, Patricia Margaritte-Jeannin, Kathleen C Barnes, William O C Cookson, Janine Altmüller, Wei Ang, R Graham Barr, Terri H Beaty, Allan B Becker, John Beilby, Hans Bisgaard, Unnur Steina Bjornsdottir, Eugene Bleecker, Klaus Bønnelykke, Dorret I Boomsma, Emmanuelle Bouzigon, Christopher E Brightling, Myriam Brossard, Guy G Brusselle, Esteban Burchard, Kristin M Burkart, Andrew Bush, Moira Chan-Yeung, Kian Fan Chung, Alexessander Couto Alves, John A Curtin, Adnan Custovic, Denise Daley, Johan C de Jongste, Blanca E Del-Rio-Navarro, Kathleen M Donohue, Liesbeth Duijts, Celeste Eng, Johan G Eriksson, Martin Farrall, Yuliya Fedorova, Bjarke Feenstra, Manuel A Ferreira, Maxim B Freidin, Zofia Gajdos, Jim Gauderman, Ulrike Gehring, Frank Geller, Jon Genuneit, Sina A Gharib, Frank Gilliland, Raquel Granell, Penelope E Graves, Daniel F Gudbjartsson, Tari Haahtela, Susan R Heckbert, Dick Heederik, Joachim Heinrich, Markku Heliövaara, John Henderson, Blanca E Himes, Hiroshi Hirose, Joel N Hirschhorn, Albert Hofman, Patrick Holt, Jouke Hottenga, Thomas J Hudson, Jennie Hui, Medea Imboden, Vladimir Ivanov, Vincent W V Jaddoe, Alan James, Christer Janson, Marjo-Riitta Jarvelin, Deborah Jarvis, Graham Jones, Ingileif Jonsdottir, Pekka Jousilahti, Michael Kabesch, Mika Kähönen, David B Kantor, Alexandra S Karunas, Elza Khusnutdinova, Gerard H Koppelman, Anita L Kozyrskyj, Eskil Kreiner, Michiaki Kubo, Rajesh Kumar, Ashish Kumar, Mikko Kuokkanen, Lies Lahousse, Tarja Laitinen, Catherine Laprise, Mark Lathrop, Susanne Lau, Young-Ae Lee, Terho Lehtimäki, Sébastien Letort, Albert M Levin, Guo Li, Liming Liang, Laura R Loehr, Stephanie J London, Daan W Loth, Ani Manichaikul, Ingo Marenholz, Fernando J Martinez, Melanie C Matheson, Rasika A Mathias, Kenji Matsumoto, Hamdi Mbarek, Wendy L McArdle, Mads Melbye, Erik Melén, Deborah Meyers, Sven Michel, Hamida Mohamdi, Arthur W Musk, Rachel A Myers, Maartje A E Nieuwenhuis, Emiko Noguchi, George T O'Connor, Ludmila M Ogorodova, Cameron D Palmer, Aarno Palotie, Julie E Park, Craig E Pennell, Göran Pershagen, Alexey Polonikov, Dirkje S Postma, Nicole Probst-Hensch, Valery P Puzyrev, Benjamin A Raby, Olli T Raitakari, Adaikalavan Ramasamy, Stephen S Rich, Colin F Robertson, Isabelle Romieu, Muhammad T Salam, Veikko Salomaa, Vivi Schlünssen, Robert Scott, Polina A Selivanova, Torben Sigsgaard, Angela Simpson, Valérie Siroux, Lewis J Smith, Maria Solodilova, Marie Standl, Kari Stefansson, David P Strachan, Bruno H Stricker, Atsushi Takahashi, Philip J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Carla M T Tiesler, Dara G Torgerson, Tatsuhiko Tsunoda, André G Uitterlinden, Ralf J P van der Valk, Amaury Vaysse, Sailaja Vedantam, Andrea von Berg, Erika von Mutius, Judith M Vonk, Johannes Waage, Nick J Wareham, Scott T Weiss, Wendy B White, Magnus Wickman, Elisabeth Widén, Gonneke Willemsen, L Keoki Williams, Inge M Wouters, James J Yang, Jing Hua Zhao, Miriam F Moffatt, Carole Ober, Dan L Nicolae
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases...
January 2018: Nature Genetics
https://www.readbyqxmd.com/read/29261288/optimization-of-the-pore-structure-of-biomass-based-carbons-in-relation-to-their-use-for-co2-capture-at-low-and-high-pressure-regimes
#15
Marta Sevilla, Abdul Salam M Al-Jumialy, Antonio B Fuertes, Robert Mokaya
A versatile chemical activation approach for the fabrication of sustainable porous carbons with a pore network tunable from micro- to hierarchical micro-/mesoporous is hereby presented. It is based on the use of a less corrosive and less toxic chemical, i.e. potassium oxalate, than the widely used KOH. The fabrication procedure is exemplified for glucose as precursor, although it can be extended to other biomass derivatives (saccharides) with similar results. When potassium oxalate alone is used as activating agent, highly microporous carbons are obtained (SBET ~ 1300 - 1700 m2 g-1)...
December 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29251012/enhancing-effect-of-hydroxyurea-on-hb-f-in-sickle-cell-disease-ten-year-egyptian-experience
#16
Ilham Youssry, Amina Abdel-Salam, Rania Ismail, Rayan Bou-Fakhredin, Rania Mohamed Samy, Fatma Ezz El-Deen, Ali T Taher
Patients with sickle cell disease experience hemolytic anemia and vaso-occlusions that result in pain, organ injury, and premature mortality. Several prospective studies have verified the efficacy and tolerability of hydroxyurea (HU), and demonstrated its efficacy in reducing painful vaso-occlusive crises (VOCs) in addition to its ability to increase Hb F levels. We aimed to evaluate the long-term effects of HU therapy on Hb F and assess its long term efficacy and safety in sickle cell disease patients. A retrospective study on 60 sickle cell disease patients was conducted...
December 18, 2017: Hemoglobin
https://www.readbyqxmd.com/read/29248085/recommendations-on-arresting-global-health-challenges-facing-adolescents-and-young-adults
#17
Zohra S Lassi, Rehana A Salam, Zulfiqar A Bhutta
BACKGROUND: The health challenges faced by young people are more complex than adults and can compromise their full growth and development. Attention must be paid to the health of this age group, yet adolescents and youth remain largely invisible and often disappear from the major global datasets. OBJECTIVE: The aim of this paper is to discuss the global health challenges faced by adolescents and youth, global legislations and guidelines pertaining to this particular age group, recommendations to arrest these challenges, and research priorities...
September 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29246671/histology-of-thrombectomy-specimen-reveals-cardiac-tumor-embolus-in-cryptogenic-young-stroke
#18
Kizhakkaniyakath Abdu Salam, Mohammed Rafeeque, Hisham Hashim, Neena Mampilly, Mohan Leslie Noone
A 25-year-old woman presented with acute onset of right hemiplegia and global aphasia with National Institutes of Health Stroke Scale score of 19. Computed tomography angiography demonstrated occlusion of the left proximal middle cerebral artery. She was thrombolysed with intravenous recombinant tissue plasminogen activator (0.6 mg/kg) within 3 hours of onset of symptoms and was taken up for mechanical thrombectomy. The retrieved specimen appeared pale white and soft; histopathologic examination revealed a papillary neoplasm composed of papillae with hyalinized cores lined by endothelium, consistent with papillary fibroelastoma of cardiac origin...
December 12, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29237664/giant-retrocardiac-foregut-duplication-cyst-presenting-with-left-atrial-compression-and-palpitations
#19
Abdus Salam, Mujtaba Mubashir, Hadika Mubashir, Saulat Hasnain Fatimi
A 35-year-old man presented with a 3-month history of palpitations and shortness of breath. An ECG showed premature atrial contractions and episodes of supraventricular tachycardia. A subsequent echocardiogram showed a retrocardiac cystic mass that was compressing the left atrium. A CT scan confirmed these findings by showing a large left-sided posterior mediastinal cyst compressing the left atrium and pulmonary veins. The cyst was successfully excised from the retrocardiac position via left thoracotomy after which there was complete resolution of the palpitations...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29237190/determination-of-acid-and-neutral-cannabinoids-in-extracts-of-different-strains-of-cannabis-sativa-using-gc-fid
#20
Elsayed A Ibrahim, Waseem Gul, Shahbaz W Gul, Brandon J Stamper, Ghada M Hadad, Randa A Abdel Salam, Amany K Ibrahim, Safwat A Ahmed, Suman Chandra, Hemant Lata, Mohamed M Radwan, Mahmoud A ElSohly
Cannabis (Cannabis sativa L.) is an annual herbaceous plant that belongs to the family Cannabaceae. Trans-Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two major phytocannabinoids accounting for over 40% of the cannabis plant extracts, depending on the variety. At the University of Mississippi, different strains of C. sativa, with different concentration ratios of CBD and Δ9-THC, have been tissue cultured via micropropagation and cultivated. A GC-FID method has been developed and validated for the qualitative and quantitative analysis of acid and neutral cannabinoids in C...
December 13, 2017: Planta Medica
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