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https://www.readbyqxmd.com/read/28738336/innate-immune-memory-implications-for-microglial-function-and-neuroprogression
#1
Alex P Salam, Carmine M Pariante, Patricia Zunszain
Immunostimulatory insults such as stress and infection are risk factors for the development of several neuropsychiatric disorders characterized by neuroprogression. Inflammatory and neurotoxic molecules in the brain can cause disruptions in neurogenesis, neuronal excitability, synaptic transmission, synaptic plasticity, and neuronal survival - changes that characterize neuroprogression. We draw on recent findings in the immunology literature that peripheral innate immune cells are capable of retaining long-term memory of infectious insults and displaying long-lasting upregulated proinflammatory function in response to repeated infectious insults - a concept known as "innate immune memory...
July 24, 2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28732090/incidence-predictors-and-severity-of-adverse-events-among-whole-blood-donors
#2
Hamdan Almutairi, Mahmoud Salam, Abdulaziz Alajlan, Faisal Wani, Bushra Al-Shammari, Khaled Al-Surimi
BACKGROUND: Adverse events have been reported post blood donation. Donors might refrain from donating again due to such events which lowers the blood supply in collection centers. AIM: This study measured the incidence, predictors and severity of adverse events among donors of a single whole blood unit at one of the largest donation centers in Saudi Arabia. METHODS: A retrospective cohort was conducted in 2015 to investigate the adverse events immediately post donation...
2017: PloS One
https://www.readbyqxmd.com/read/28730747/study-of-the-prevalence-of-5-ht-2c-receptor-gene-polymorphisms-in-egyptian-patients-with-lifelong-premature-ejaculation
#3
M F Roaiah, Y I Elkhayat, L A Rashed, S F GamalEl Din, A M El Guindi, M A Abd El Salam
We investigated the prevalence of 5HT2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation. A total of 350 participants were enrolled in a prospective study. Two hundred and forty-five cases with lifelong premature ejaculation joined this study, in addition to 105 controls. We instructed the partners of the cases to measure the IELT of the first intercourse only using a stopwatch for 1 month. Genotyping was carried out at the end of the study. The results showed that the majority of the patients and controls were Cys/Cys...
July 21, 2017: Andrologia
https://www.readbyqxmd.com/read/28724813/correlation-between-the-graft-host-junction-of-penetrating-keratoplasty-by-anterior-segment-optical-coherence-tomography-and-the-magnitude-of-postoperative-astigmatism
#4
Ghada Azab Nassar, Shaimaa Abd El Salam Arfeen
PURPOSE: This study aimed to evaluate the alignment pattern of the graft-host junction after penetrating keratoplasty (PK) by anterior segment-optical coherence tomography (AS-OCT) and to correlate this pattern with the magnitude of postoperative astigmatism. METHODS: This retrospective observational study was carried out on forty patients who underwent PK from February 2013 to August 2014. AS-OCT was performed, and the graft-host junctions were classified into well-apposed junction, malapposed junction, and equally apposed junction...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724188/bisindole-oxadiazole-hybrids-t3p-%C3%A2-mediated-synthesis-and-appraisal-of-their-apoptotic-antimetastatic-and-computational-bcl-2-binding-potential
#5
Pooja R Kamath, Manu M Joseph, Abdul Ajees Abdul Salam, Sreelekha T Therakathinal, Dhanya Sunil, Subhankar Biswas, Karkala Sreedhara Ranganath Pai
In the pursuit of novel anticancer leads, new bisindole-oxadiazoles were synthesized using propyl phosphonic anhydride as a mild and efficient reagent. The molecule, 3-[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]-1H-indole (3a) exhibited selective cytotoxicity to MCF-7 cells with a cell cycle arrest in the G1 phase. The mechanism of cytotoxicity of 3a involved caspase-2-dependent apoptotic pathway with characteristic apoptotic morphological alterations as observed in acridine orange/ethidium bromide and Hoechst staining...
July 19, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28718249/frequency-of-undiagnosed-chronic-obstructive-pulmonary-disease-in-patients-with-coronary-artery-disease
#6
Raza Ullah, Shahid Salam, Tahir Ghaffar, Rahim Muhammad, Imran Khan
BACKGROUND: Chronic obstructive airway disease (COPD) is considered as risk factor for coronary artery disease (CAD) along with other risk factors. This study was conducted to determine the frequency of undiagnosed chronic obstructive pulmonary disease in patients with coronary artery disease. METHODS: This cross-sectional study was conducted in the Pulmonology and Cardiology wards/OPD's of Khyber Teaching Hospital Peshawar. Patients more than 35 years of age, diagnosed with CAD of either gender were included...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28715338/closed-loop-neurostimulators-a-survey-and-a-seizure-predicting-design-example-for-intractable-epilepsy-treatment
#7
Hossein Kassiri, Sana Tonekaboni, M Tariqus Salam, Nima Soltani, Karim Abdelhalim, Jose Luis Perez Velazquez, Roman Genov
First, existing commercially available open-loop and closed-loop implantable neurostimulators are reviewed and compared in terms of their targeted application, physical size, system-level features, and performance as a medical device. Next, signal processing algorithms as the primary strength point of the closed-loop neurostimulators are reviewed, and various design and implementation requirements and trade-offs are discussed in details along with quantitative examples. The review results in a set of guidelines for algorithm selection and evaluation...
July 17, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28712175/corneal-complications-and-visual-impairment-in-vernal-keratoconjunctivitis-patients
#8
Abdus Salam Arif, Bushra Aaqil, Afsheen Siddiqui, Zainab Nazneen, Umer Farooq
BACKGROUND: Vernal kerato-conjunctivitis (VKC) is an infrequent but serious form of allergic conjunctivitis common in warm and humid areas where air is rich in allergens. It affects both eyes asymmetrically. Although VKC is a self-limiting disease but visions affecting corneal complications influence the quality of life in school children. The aim of this study was to list the corneal complications due to this condition and to find out the extent of visual impairment among VKC patients...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28710059/a-foxo1-induced-oncogenic-network-defines-the-aml1-eto-pre-leukemic-program
#9
Shan Lin, Anetta Ptasinska, Xiaoting Chen, Mahesh Shrestha, Salam A Assi, Paulynn S Chin, Maria R Imperato, Bruce Aronow, Jingsong Zhang, Matthew T Weirauch, Constanze Bonifer, James C Mulloy
Understanding and blocking the self-renewal pathway of pre-leukemia stem cells could prevent acute myeloid leukemia (AML) relapse. In this study we show that increased FOXO1 represents a critical mechanism driving aberrant self-renewal in pre-leukemic cells expressing the t(8;21)-associated oncogene AML1-ETO (AE). Though generally considered as a tumor suppressor, FOXO1 is consistently upregulated in t(8;21) AML. Expression of FOXO1 in human CD34+ cells promotes a pre-leukemic state with enhanced self-renewal and dysregulated differentiation...
July 14, 2017: Blood
https://www.readbyqxmd.com/read/28708216/colonoscopy-in-automated-peritoneal-dialysis-patients-value-of-prophylactic-antibiotics-a-prospective-study-on-a-single-antibiotic
#10
Abdullah K Al-Hwiesh, Ibrahiem S Abdul-Rahman, Mohammad A Hussameldeen, Nadia Al-Audah, Abdalla Abdelrahman, Hala M Moaigel, Tamer El-Salamony, Abdul-Salam Noor, Aisha Al-Osail, Dalal Al-Sayel, Nourah Al-Dossari
OBJECTIVE: To evaluate the need for prophylactic antibiotics in automated peritoneal dialysis (APD) patients undergoing flexible colonoscopy. PATIENTS AND METHODS: A total of 93 patients on automated peritoneal dialysis (APD) undergoing diagnostic colonoscopy were enrolled in a prospective, randomized study. Patients were randomized into 2 age- and sex-matched groups; group A (46 patients) with intraperitoneal (IP) ceftazidime prior to colonoscopy and group B (47 patients) without prophylactic antibiotics...
July 5, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28704972/impact-of-first-aid-on-treatment-outcomes-for-non-fatal-injuries-in-rural-bangladesh-findings-from-an-injury-and-demographic-census
#11
Dewan Md Emdadul Hoque, Md Irteja Islam, Shumona Sharmin Salam, Qazi Sadeq-Ur Rahman, Priyanka Agrawal, Aminur Rahman, Fazlur Rahman, Shams El-Arifeen, Adnan A Hyder, Olakunle Alonge
Non-fatal injuries have a significant impact on disability, productivity, and economic cost, and first-aid can play an important role in improving non-fatal injury outcomes. Data collected from a census conducted as part of a drowning prevention project in Bangladesh was used to quantify the impact of first-aid provided by trained and untrained providers on non-fatal injuries. The census covered approximately 1.2 million people from 7 sub-districts of Bangladesh. Around 10% individuals reported an injury event in the six-month recall period...
July 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28697715/conversion-from-once-daily-prolonged-release-tacrolimus-to-once-daily-extended-release-tacrolimus-in-stable-liver-transplant-recipients
#12
Mario Altieri, Guillaume Delaval, Elisabeth Kimmoun, Manon Allaire, Ephrem Salamé, Jérôme Dumortier
OBJECTIVES: After organ transplant, strategies to simplify the therapeutic regimen may improve adherence and prevent rejection and/or graft loss. The aim of the present study was to evaluate the safety of conversion from once-daily prolonged-release tacrolimus (Advagraf; Astellas Pharma Europe Limited, Middlesex, UK) to once-daily extended-release tacrolimus (Envarsus; Chiesi SAS, Nanterre, France) in stable adult liver transplant recipients. MATERIALS AND METHODS: This observational study inclu-ded 44 liver transplant patients (median age of 59 y; 63...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28697347/immediate-reconstruction-and-dental-rehabilitation-of-segmental-mandibular-defects-description-of-a-novel-technique
#13
Salam O Salman, Rui P Fernandes, Sundeep R Rawal
The aim of this report is to present a new technique using current technologic advances for immediate reconstruction and dental rehabilitation of segmental mandibular defects with a screw-retained prosthesis. One case is reviewed and a detailed review of surgical and prosthetic techniques used is presented.
June 23, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28694110/predictors-of-in-hospital-mortality-after-decompressive-hemicraniectomy-for-malignant-ischemic-stroke
#14
Saadat Kamran, Abdul Salam, Naveed Akhtar, Aymen Alboudi, Arsalan Ahmad, Rabia Khan, Rashed Nazir, Muhammad Nadeem, Jihad Inshasi, Ahmed ElSotouhy, Ghanim Al Sulaiti, Ashfaq Shuaib
OBJECTIVE: The purpose of this retrospective multicenter, pooled-data analysis was to determine the factors associated with in-hospital mortality in decompressive hemicraniectomy (DHC) for malignant middle cerebral artery (MMCA) stroke. PATIENTS AND METHODS: The authors reviewed pooled DHC database from 3 countries for patients with MMCA with hospital mortality in spite of DHC to identify factors that predicted in-hospital mortality after DHC. The identified factors were applied to the group of patients who were selected for DHC but either refused surgery and died or stabilized and did not undergo DHC...
July 7, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28691505/impact-of-chronic-kidney-disease-on-the-presentation-and-outcome-of-patients-hospitalized-with-atrial-fibrillation-insights-from-qatar
#15
Imtiaz Salim, Jassim Al Suwaidi, Hajar A AlBinali, Rajvir Singh, Awad Al-Qahtani, Nidal Asaad, Amar M Salam
Atrial fibrillation (AF) with coexistent chronic kidney disease (CKD) is poorly described in the literature. We compared the presenting symptoms, clinical characteristics, treatment, and outcome of patients hospitalized with AF with and without CKD in a large clinical registry. Data of patients hospitalized with AF between 1991 and 2012 in Qatar were analyzed. Of 5201 patients hospitalized for AF, 264 (5.1%) had CKD. Patients with AF and CKD were older with higher prevalence of other comorbidities and left ventricular dysfunction and were more likely to present with shortness of breath and chest pain compared with patients with AF alone who were more likely to present with palpitation...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28691204/mortality-with-brainstem-seizures-from-focal-4-aminopyridine-induced-recurrent-hippocampal-seizures
#16
Muhammad Tariqus Salam, Gaspard Montandon, Roman Genov, Orrin Devinsky, Martin Del Campo, Peter L Carlen
OBJECTIVE: Sudden unexplained death in epilepsy is the leading cause of death in young adult epilepsy patients, typically occurring during the early postictal period, presumably resulting from brainstem and cardiorespiratory dysfunction. We hypothesized that ictal discharges in the brainstem disrupt the cardiorespiratory network, causing mortality. To study this hypothesis, we chose an animal model comprising focal unilateral hippocampal injection of 4-aminopyridine (4-AP), which produced focal recurrent hippocampal seizures with secondary generalization in awake, behaving rats...
July 10, 2017: Epilepsia
https://www.readbyqxmd.com/read/28683781/determinants-of-complete-immunization-among-senegalese-children-aged-12-23%C3%A2-months-evidence-from-the-demographic-and-health-survey
#17
Mouhamed Abdou Salam Mbengue, Moussa Sarr, Adama Faye, Ousseynou Badiane, Fatou Bintou Niang Camara, Souleymane Mboup, Tandakha Ndiaye Dieye
BACKGROUND: The expanded Programme on Immunization (EPI) is one of the most cost-effective interventions to reduce childhood mortality and morbidity. However, determinants of childhood immunization have not been well studied in Senegal. Thus, the aim of our study is to assess routine immunization uptake and factors associated with full immunization status among Senegalese children aged 12-23 months. METHODS: We used the 2010-2011 Senegalese Demographic and Health Survey data...
July 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28682775/molecular-phylogeny-of-the-haplosplanchnata-olson-cribb-tkach-bray-and-littlewood-2003-with-a-description-of-schikhobalotrema-huffmani-n-sp
#18
Daniel C Huston, Scott C Cutmore, Thomas H Cribb
We describe Schikhobalotrema huffmani n. sp. from Tylosurus crocodilus (Péron and Leseur) (Belonidae) collected off Lizard Island, Great Barrier Reef, Queensland, Australia and Tylosurus gavialoides (Castelnau) collected from Moreton Bay, Queensland. Schikhobalotrema huffmani n. sp., along with Schikhobalotrema ablennis (Abdul-Salam and Khalil, 1987) Madhavi, 2005, Schikhobalotrema acutum (Linton, 1910) Skrjabin and Guschanskaja, 1955 and Schikhobalotrema adacutum (Manter, 1937) Skrjabin and Guschanskaja, 1955 are distinguished from all other species of Schikhobalotrema Skrjabin and Guschanskaja, 1955 in having ventral suckers which bear lateral lobes and have longitudinal apertures...
September 26, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28671520/cysteiniphilum-litorale-gen-nov-sp-nov-isolated-from-coastal-seawater
#19
Lan Liu, Nimaichand Salam, Jian-Yu Jiao, Shun-Mei E, Cha Chen, Bao-Zhu Fang, Min Xiao, Mo Li, Wen-Jun Li, Ping-Hua Qu
A taxonomic study was performed on strain SYSU D3-2T, isolated from coastal seawater near the estuary of Pearl River in southern China. The strain was observed to be Gram-reaction-negative, non-motile and non-spore-forming. Cells were found to be of coccobacilli shape. Chemotaxonomic analysis of the plasma membrane revealed ubiquinone-8 as the respiratory quinone, diphosphatidylglycerol, phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, an unidentified aminolipid, an unidentified aminophospholipid and an unidentified phospholipid as the polar lipids, and anteiso-C15 : 0, C18 : 0 and anteiso-C17 : 0 as the major fatty acids (>10 % of total fatty acids)...
July 3, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28667456/from-clinical-trials-to-clinical-practice-outcome-of-nsabp-b27-neoadjuvant-chemotherapy-regimen-for-high-risk-early-stage-breast-cancer
#20
Hikmat Abdel-Razeq, Lina Marei, Salwa S Saadeh, Hazem Abdulelah, Mahmoud Abu-Nasser, Mourad Salam, Walid Daana, Basel Al-Haj Ali, Ayat Taqash
PURPOSE: Majority of Jordanian breast cancer patients present at a relatively young age and with locally advanced disease highlight the importance of neoadjuvant chemotherapy. This study evaluated the efficacy and safety of NSABP-B27 regimen in high-risk patients in daily clinical practice. METHODS: Patients' medical records and hospital database were searched for all consecutive patients treated at our institution for breast cancer using neoadjuvant NSABP-B27 chemotherapy regimen...
June 30, 2017: Breast Cancer Research and Treatment
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