Jiayou Liu, Luda Feng, Qi Jia, Jia Meng, Yun Zhao, Lei Ren, Ziming Yan, Manrui Wang, Jianguo Qin
Mitophagy, the selective removal of damaged mitochondria, plays a critical role in kidney diseases, but its involvement in hypertensive nephropathy (HTN) is not well understood. To address this gap, we investigated mitophagy-related genes in HTN, identifying potential biomarkers for diagnosis and treatment. Transcriptome datasets from the Gene Expression Omnibus database were analyzed, resulting in the identification of seven mitophagy related differentially expressed genes (MR-DEGs), namely PINK1, ULK1, SQSTM1, ATG5, ATG12, MFN2, and UBA52...
February 9, 2024: Journal of Biomolecular Structure & Dynamics