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https://www.readbyqxmd.com/read/29149811/testing-actions-of-a-multi-action-emollient-patient-acceptability-efficacy-skin-biophysiology-and-staphylococcal-isolation
#1
Kam Lun E Lun Hon
AIM: Eczema or atopic dermatitis (AD) is associated with itch, sleep disturbance, impaired life quality, reduced skin hydration, impaired epidermal barrier function and colonization by Staphylococcus aureus (SA). We investigated an emollient with claimed multi-actions on barrier repair, antihistaminergic and antimicrobial effects. METHODS: Consecutive AD patients were recruited. Swabs and cultures from eczematous areas, disease severity (SCORAD), quality-of-life (Children Dermatology Life Quality Index, CDLQI), skin hydration (SH), and transepidermal water loss (TEWL) were obtained before and 4-week following usage of the emollient...
November 16, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29136293/efficacy-and-safety-of-tofacitinib-for-moderate-to-severe-plaque-psoriasis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
C-M Kuo, T-H Tung, S-H Wang, C-C Chi
The effects of tofacitinib in treating moderate-to-severe plaque psoriasis were unclear. We aimed to assess the effects of tofacitinib in treating moderate-to-severe plaque psoriasis. We searched PubMed, Cochrane Central Register of Controlled Trials, and EMBASE for relevant randomised controlled trials (RCTs), and conducted a systematic review and meta-analysis. Four RCTs with 2,724 participants were included. Compared to placebo, tofacitinib significantly improved psoriasis (≥ 75% reduction in the Psoriasis Area and Severity Index score: 5 mg BID: risk difference (RD) 0...
November 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29128337/the-urticaria-activity-score-validity-reliability-and-responsiveness
#3
Tomasz Hawro, Tatevik Ohanyan, Nicole Schoepke, Martin Metz, Adriane Peveling-Oberhag, Petra Staubach, Marcus Maurer, Karsten Weller
BACKGROUND: Chronic spontaneous urticaria is characterized by fluctuating symptoms. Its activity is assessed with the urticaria activity score (UAS). Two versions of the urticaria activity score used for 7 consecutive days (UAS7) are available: (1) The guideline-recommended UAS7, with once-daily documentation, and (2) the UAS7TD, with twice-daily documentation. OBJECTIVE: To better characterize both UAS7 versions with regard to their validity, reliability, sensitivity to change, minimal important difference (MID), and smallest detectable change (SDC)...
November 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29118518/insignificant-correlation-between-thyroid-hormone-and-antithyroid-peroxidase-antibodies-in-alopecia-areata-patients-in-northern-rajasthan
#4
Gagandeep Kaur, C M Kuldeep, Puneet Bhargava, Deepak Kumar Mathur, Sonam Sharda, Pulkit Chaturvedi
Background: Alopecia areata (AA) is a common, recurrent form of nonscarring alopecia which often presents as circumscribed patches of spontaneous hair loss. The global prevalence of this disease varies from 0.1% to 0.2% in general population and 7-30 cases per 1000 dermatological patients. The etiology of AA still remains uncertain; however, genetic or environmental factor and autoimmunity are claimed responsible for it. Various autoimmune diseases, such as Hashimoto's thyroiditis, diabetes mellitus, vitiligo, and lupus erythematosus, have been reported in association with AA...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29114938/immune-response-patterns-in-non-communicable-inflammatory-skin-diseases
#5
REVIEW
Kilian Eyerich, Stefanie Eyerich
Non-communicable inflammatory skin diseases (ncISD) such as psoriasis or atopic eczema are a major cause of global disease burden. Due to their impact and complexity, ncISD represent a major challenge of modern medicine. Dermatology textbooks describe more than 100 different ncISD based on clinical phenotype and histological architecture. In the last decades, this historical description was complemented by increasing molecular knowledge - and this knowledge is now being translated into specific therapeutics...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29099667/redefining-the-therapeutic-objective-in-psoriatic-patients-candidates-for-biological-therapy
#6
G Carretero, L Puig, J M Carrascosa, L Ferrándiz, R Ruiz-Villaverde, P de la Cueva, I Belinchon, E Vilarrasa, R Del Rio, J L Sánchez-Carazo, A López-Ferrer, F Peral, S Armesto, N Eiris, J Mitxelena, J Vilar, M Ara, C Soria
The advances in psoriasis management currently allow achieving a good control of the disease. In particular, with the latest developed molecules, available evidence suggests that it is possible to pose an ambitious therapeutic goal, such as a Dermatology Life Quality Index 0/1, a Physician Global Assessment 0/1, or a Psoriasis Area and Severity Index 90/100 response. However, patients often fail to achieve the complete clearance of their cutaneous lesions or the improvement of disease factors that impair their quality of life...
November 3, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29078254/stress-and-skin-disease-quality-of-life-the-moderating-role-of-anxiety-sensitivity-social-concerns
#7
L J Dixon, S M Witcraft, N K McCowan, R T Brodell
BACKGROUND: Stress is an important factor in the onset, exacerbation, and reoccurrence of many skin diseases. Little is known about psychological risk factors that impact the association between stress and dermatologic conditions. One relevant factor that may modulate this link is anxiety sensitivity (AS) social concerns - the propensity to respond fearfully to anxiety-related sensations (e.g., sweating, flushing) due to perceived social consequences (e.g., rejection or humiliation). OBJECTIVE: To gain insight into psychological factors affecting skin disease, we examined the moderating role of AS social concerns in the relation between stress and skin disease quality of life (QOL)...
October 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29064988/signs-of-facial-aging-in-men-in-a-diverse-multinational-study-timing-and-preventive-behaviors
#8
MULTICENTER STUDY
Anthony M Rossi, Joseph Eviatar, Jeremy B Green, Robert Anolik, Michael Eidelman, Terrence C Keaney, Vic Narurkar, Derek Jones, Julia Kolodziejczyk, Adrienne Drinkwater, Conor J Gallagher
BACKGROUND: Men are a growing patient population in aesthetic medicine and are increasingly seeking minimally invasive cosmetic procedures. OBJECTIVE: To examine differences in the timing of facial aging and in the prevalence of preventive facial aging behaviors in men by race/ethnicity. METHODS: Men aged 18 to 75 years in the United States, Canada, United Kingdom, and Australia rated their features using photonumeric rating scales for 10 facial aging characteristics...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29055155/apremilast-for-the-treatment-of-moderate-to-severe-palmoplantar-psoriasis-results-from-a-double-blind-placebo-controlled-randomized-study
#9
R Bissonnette, R Haydey, L Rosoph, C W Lynde, M Bukhalo, J Fowler, I Delorme, A Gagné-Henley, M Gooderham, Y Poulin, K Barber, P Jenkin, I Landells, D Pariser
BACKGROUND: Palmoplantar psoriasis is a variant of psoriasis vulgaris which can severely impair quality of life. OBJECTIVES: The main objectives of this double-blind, placebo-controlled, randomized study were to assess the efficacy and impact on quality of life and work productivity of apremilast for the treatment of moderate to severe palmoplantar psoriasis. METHODS: A total of 100 patients with moderate to severe palmoplantar psoriasis were randomized to either apremilast 30mg bid or placebo for 16 weeks...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28991357/the-prevalence-of-psychological-co-morbidity-in-people-with-vitiligo-a-systematic-review-and-meta-analysis
#10
O Osinubi, M J Grainge, L Hong, A Ahmed, J M Batchelor, D Grindlay, A R Thompson, S Ratib
BACKGROUND: Vitiligo is a chronic disorder causing skin depigmentation with global prevalence varying from 0.2 to 1.8%. UK guidelines recommend assessment of psychological state during clinical evaluation of vitiligo. However, the prevalence of psychological co-morbidity in people with vitiligo has not been described. OBJECTIVES: We aimed to establish the prevalence of psychological symptoms or disorders in people with vitiligo and describe the outcome measures used...
October 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28964451/measurement-properties-of-the-psoriasis-symptom-inventory-electronic-daily-diary-in-patients-with-moderate-to-severe-plaque-psoriasis
#11
Hema N Viswanathan, Alex Mutebi, Cassandra E Milmont, Kenneth Gordon, Hilary Wilson, Hao Zhang, Paul A Klekotka, Dennis A Revicki, Matthias Augustin, Gregory Kricorian, Ajay Nirula, Bruce Strober
OBJECTIVES: The Psoriasis Symptom Inventory (PSI) is a patient-reported outcome instrument that measures the severity of psoriasis signs and symptoms. This study evaluated measurement properties of the PSI in patients with moderate to severe plaque psoriasis. METHODS: This secondary analysis used pooled data from a phase 3 brodalumab clinical trial (AMAGINE-1). Outcome measures included the PSI, Psoriasis Area and Severity Index (PASI), static Physician's Global Assessment (sPGA), psoriasis-affected body surface area, 36-item Short-Form Health Survey version 2, and the Dermatology Life Quality Index (DLQI)...
September 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28960570/clinical-interpretation-of-the-uremic-pruritus-in-dialysis-patients-up-dial-scale-a-novel-instrument-for-the-assessment-of-uremic-pruritus
#12
S Nochaiwong, C Ruengorn, K Koyratkoson, C Chaisai, R Awiphan, K Thavorn, K Noppakun, Y Suteeka, S Panyathong, W Chongruksut, S Nanta, S Chiewchanvit
BACKGROUND: The Uremic Pruritus in Dialysis Patients (UP-Dial) scale is valid and reliable for uremic pruritus (UP) assessment. However, it remains unknown how the scores should be interpreted in clinical practices. OBJECTIVES: To establish a clinical interpretation of the UP-Dial by identifying severity cut-off scores according to the disease severity and burden of pruritus. METHODS: This cross-sectional study developed a classification system for the UP-Dial scores using the patient-based anchors method...
September 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28943206/kaolinite-in-pharmaceutics-and-biomedicine
#13
REVIEW
Mahmoud E Awad, Alberto López-Galindo, Massimo Setti, Mahmoud M El-Rahmany, César Viseras Iborra
Kaolinite Al2Si2O5(OH)4 is an abundant and inexpensive geomaterial regarded as one of the most common clay minerals in the earth's crust and the most widespread phase among the other kaolin polymorphs (halloysite, dickite and nacrite). Structurally, it is a hydrous aluminum phyllosilicate member belonging to the dioctahedral 1:1 kaolin mineral group. The particle size of the pseudohexagonal kaolinite platelets is normally <2μm (if compared to a human red blood cell of a typical diameter 6.2-8.2μm or to a virus particle of about 50nm diameter)...
November 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28940801/low-and-high-body-mass-index-in-hidradenitis-suppurativa-patients-different-subtypes
#14
P Theut Riis, D M Saunte, F Benhadou, V Del Marmol, P Guillem, M El-Domyati, H Abdel-Wahab, C Antoniou, C Dessinioti, M A Gürer, B Beksaç, J C Szepietowski, L Matusiak, L Emtestam, J Lapins, H Riad, N Doss, A F Massa, I Hamzavi, C Nicholson, M Dolenc-Voljc, K H Kim, J Ohn, C C Zouboulis, I Karagiannidis, Z B Mokos, P Durinec, G B E Jemec
INTRODUCTION: Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. MATERIALS AND METHOD: Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. RESULTS: Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0...
September 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28913735/efficacy-and-safety-of-tazarotene-0-1-plus-clindamycin-1-gel-versus-adapalene-0-1-plus-clindamycin-1-gel-in-facial-acne-vulgaris-a-randomized-controlled-clinical-trial
#15
Rituparna Maiti, Chandra Sekhar Sirka, M A Ashique Rahman, Anand Srinivasan, Sansita Parida, Debasish Hota
BACKGROUND: Acne vulgaris is a multifactorial disorder which is ideally treated with combination therapy with topical retinoids and antibiotics. OBJECTIVES: The present study was conducted to compare the efficacy and safety of tazarotene plus clindamycin against adapalene plus clindamycin in facial acne vulgaris. METHODS: This study is a randomized, open-label, parallel design clinical trial conducted on 60 patients with facial acne at the outpatient dermatology department in a tertiary healthcare center...
November 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28905999/validation-of-patient-reported-global-severity-of-atopic-dermatitis-in-adults
#16
P P Vakharia, R Chopra, R Sacotte, N Patel, S Immaneni, T White, R Kantor, D Y Hsu, J I Silverberg
BACKGROUND: Atopic dermatitis (AD) is associated with a heterogeneous presentation and clinical course. There is a lack of simple and validated severity assessments that are feasible for clinical practice and epidemiological research. OBJECTIVES: We sought to validate patient-reported global AD severity in adults. METHODS: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n = 265)...
September 14, 2017: Allergy
https://www.readbyqxmd.com/read/28903134/task-shifting-in-dermatology-a-call-to-action
#17
Danielle N Brown, Sinéad M Langan, Esther E Freeman
Clinical Question: Can task shifting be used to improve the delivery of dermatologic care in resource-poor settings worldwide? Bottom Line: Task shifting is a means of redistributing available resources, whereby highly trained individuals train an available workforce to provide necessary care in low-resource settings. Limited evidence exists for task shifting in dermatology; however, studies from psychiatry demonstrate its efficacy. In the field of dermatology there is a need for high-quality evidence including randomized clinical trials to validate the implementation of task shifting in low-resource settings globally...
November 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28892936/hazards-and-health-risks-encountered-by-manual-sand-dredgers-from-udupi-india-a-cross-sectional-study
#18
Sidhiprada Mohapatra, Alfiya Shaikh, Priyanka Nayak, Rajesh Navada
INTRODUCTION: Globalization and urbanization have resulted in an increased demand on sand dredging. Legal and environmental restrictions on automated dredging have led to a rise in manual technique. The working techniques and environment involved in manual sand dredging may expose the workers to multiple work related disorders. AIM: To determine the health risks and occupational hazards involved in manual sand dredging. MATERIALS AND METHODS: An assessment schedule was developed and content was validated by five experts for the study...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28855482/prof-masao-ota
#19
Tomomichi Ono
Masao Ota was a Professor of Dermatology at Tokyo Imperial University. He is known to dermatologists around the world as the researcher who identified Nevus of Ota. He is also known for his research on Hansen's Disease. He was critical of the forced isolation policy and the sterilization law. He dreamt of developing chemotherapeutic measures and dedicated himself to cultivating Mycobacterium leprae. Among his accomplishments, those in the area of medical mycology are particularly remarkable. His discovery of Microsporum ferrugineum, his proposal for Trichophytia pompholyciformis, and his work on Ota-Langeron taxonomy based on the findings on fungus colonies are highly regarded and earned him the Ordre Royale de la Legion D'honneur...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28834124/black-peel-in-facial-dermatoses
#20
Ebtisam Elghblawi
BACKGROUND: Melasma (facial dermatoses) is an acquired chronic disorder of hyperpigmentation over sun exposed parts and continues to be a therapeutic challenge due to the presence of melanin at varying depths in the epidermis and dermis, and many researchers are working hard to find a solution. The main culprit to remain is direct sun exposure, with other factors like drugs, genetic predisposition, thyroid abnormalities, pregnancy, phototoxic and photoallergic cosmetics. Melasma continues to have a remarkable impact on the well-being of affected patients causing deep psychological and social anguish, and with the expansion of cosmetic dermatology globally, treatments that are successful against skin diseases and boost beauty without prolonged recovery periods, or exposing patients to the risks of surgery, are increasingly recognised and acknowledged...
August 22, 2017: Journal of Cosmetic Dermatology
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