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https://www.readbyqxmd.com/read/28646580/biosimilars-for-psoriasis-worldwide-overview-of-regulatory-guidelines-uptake-and-implications-for-dermatology-clinical-practice
#1
REVIEW
A D Cohen, J J Wu, L Puig, S Chimenti, R Vender, M Rajagopalan, R Romiti, C de la Cruz, L Skov, C Zachariae, H S Young, P Foley, J M van der Walt, L Naldi, A Blauvelt
The introduction of biologic drugs for the treatment of patients with psoriasis has revolutionized treatment paradigms and enabled numerous patients to achieve disease control with an acceptable safety profile. However, the high cost of biologics limits access to these medications for the majority of patients worldwide. In recent years, the introduction of biosimilars for inflammatory diseases has become a fast evolving field. The future use of biosimilars offers the potential for decreased cost and increased access to biologic drugs for patients with psoriasis...
June 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28636793/development-and-validation-of-ihs4-a-novel-dynamic-scoring-system-to-assess-hidradenitis-suppurativa-acne-inversa-severity
#2
C C Zouboulis, T Tzellos, A Kyrgidis, G B E Jemec, F G Bechara, E J Giamarellos-Bourboulis, J R Ingram, T Kanni, I Karagiannidis, A Martorell, Ł Matusiak, A Pinter, E P Prens, D Presser, S Schneider-Burrus, E von Stebut, J C Szepietowski, H H van der Zee, S M Wilden, R Sabat
BACKGROUND: A validated tool for the dynamic severity assessment of hidradenitis suppurativa (HS) is lacking. The aim of this study was to develop and validate such a novel scoring system. METHODS: A Delphi voting procedure was conducted among the members of the European Hidradenitis Suppurativa Foundation (EHSF) to achieve consensus towards an initial HS Severity Score System (HS4). Strengths and weaknesses of HS4 were examined by a multicenter prospective study...
June 21, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28620064/sleep-disturbance-in-psoriatic-disease-prevalence-and-associated-factors
#3
Ian T Y Wong, Vinod Chandran, Suzanne Li, Dafna D Gladman
OBJECTIVE: We aimed to determine the prevalence and quality of sleep in patients with psoriatic arthritis (PsA) and those with psoriasis without PsA (PsC) followed in the same center, to identify factors associated with sleep disturbance, and to compare findings to those of healthy controls (HC). METHODS: The study included 113 PsA [ClASsification for Psoriatic ARthritis (CASPAR) criteria] and 62 PsC (PsA excluded by a rheumatologist) patients and 52 HC. Clinical variables were collected using a standard protocol...
June 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28617145/defining-treatment-success-in-rosacea-as-clear-may-provide-multiple-patient-benefits-results-of-a-pooled-analysis
#4
Guy Webster, Martin Schaller, Jerry Tan, J Mark Jackson, Nabil Kerrouche, Gregor Schäfer
Background Rosacea treatment success is usually defined as a score of 1 ("almost clear") or 0 ("clear") on the 5-point Investigator Global Assessment (IGA) scale. Objective To evaluate whether after successful treatment, "clear" subjects had better outcomes than "almost clear" subjects. Methods A pooled analysis was performed on 1366 rosacea subjects from 4 randomized controlled trials with IGA before and after treatment (ivermectin, metronidazole or vehicle). Assessments included the Dermatology Life Quality Index (DLQI) questionnaire and subject assessment of rosacea improvement...
June 15, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28597709/philippine-academy-of-rehabilitation-medicine-emergency-basic-relief-and-medical-aid-mission-project-november-2013-february-2014-the-role-of-physiatrists-in-super-typhoon-haiyan
#5
Filipinas Ganchoon, Rommel Bugho, Liezel Calina, Rochelle Dy, James Gosney
BACKGROUND: Physiatrists have provided humanitarian assistance in recent large-scale global natural disasters. Super Typhoon Haiyan, the deadliest and most costly typhoon in modern Philippine history, made landfall on 8 November 2013 resulting in significant humanitarian needs. METHODS: Philippine Academy of Rehabilitation Medicine physiatrists conducted a project of 23 emergency basic relief and medical aid missions in response to Super Typhoon Haiyan from November 2013 to February 2014...
June 9, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28555722/the-global-state-of-psoriasis-disease-epidemiology-a-workshop-report
#6
C E M Griffiths, J M van der Walt, D M Ashcroft, C Flohr, L Naldi, T Nijsten, M Augustin
The International Psoriasis Council, a global nonprofit organization dedicated to innovation across the full spectrum of psoriasis, led a symposium to discuss the current state of psoriasis epidemiology and to introduce the vision and development of a Global Psoriasis Atlas. The symposium was held on 9 September 2015 at the 45th annual meeting of the European Society for Dermatological Research, Rotterdam, the Netherlands. Collectively, these presentations highlighted challenges associated with assessing psoriasis epidemiology and emphasized the urgent need for an authoritative resource to clarify psoriasis disease burden on a global scale...
May 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28542874/comparison-of-ixekizumab-with-ustekinumab-in-moderate-to-severe-psoriasis-24-week-results-from-ixora-s-a-phase-3-study
#7
K Reich, A Pinter, J P Lacour, C Ferrandiz, G Micali, L E French, M Lomaga, Y Dutronc, C Henneges, S Wilhelm, S Hartz, C Paul
BACKGROUND: The interleukin (IL)-23/IL-17 axis has been shown critical in the pathogenesis of psoriasis. OBJECTIVES: To present the primary endpoint (Week 12) and safety/efficacy data up to Week 24 from a head-to-head trial (IXORA-S) of the IL-17A inhibitor, ixekizumab (IXE), vs. the IL-12/23 inhibitor ustekinumab (UST). METHODS: Randomised patients received IXE (160-mg starting dose, then 80 mg every two weeks for 12 weeks, then 80 mg every four weeks, N=136) or UST (45 mg/90 mg weight-based dosing per label, N=166)...
May 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28537860/global-skin-diseases-on-instagram-hashtags
#8
Taylor Braunberger, Jessica Mounessa, Kyle Rudningen, Cory A Dunnick, Robert P Dellavalle
Recently named one of the most influential phone applications, Instagram continues to grow in popularity [1]. Instagram consists of images and video posts, making it ideal for education and communication within the visual field of dermatology. In this study, we seek to determine the presence of dermatology-related content with regard to the most common cutaneous diseases of the world. We searched the account types and hashtags associated with the eight most common skin diseases globally as identified by the Global Burden of Disease (GBD) study by Hollenstein et al...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28522039/injectable-and-topical-neurotoxins-in-dermatology-indications-adverse-events-and-controversies
#9
REVIEW
Cerrene N Giordano, Seth L Matarasso, David M Ozog
The use of neuromodulators for therapeutic and cosmetic indications has proven to be remarkably safe. While aesthetic and functional adverse events are uncommon, each anatomic region has its own set of risks of which the physician and patient must be aware before treatment. The therapeutic usages of botulinum toxins now include multiple specialties and multiple indications. New aesthetic indications have also developed, and there has been an increased utilization of combination therapies to combat the effects of global aging...
June 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28516494/recommendations-for-approaches-to-meticillin-resistant-staphylococcal-infections-of-small-animals-diagnosis-therapeutic-considerations-and-preventative-measures-clinical-consensus-guidelines-of-the-world-association-for-veterinary-dermatology
#10
REVIEW
Daniel O Morris, Anette Loeffler, Meghan F Davis, Luca Guardabassi, J Scott Weese
BACKGROUND: Multiple drug resistance (MDR) in staphylococci, including resistance to the semi-synthetic penicillinase-resistant penicillins such as meticillin, is a problem of global proportions that presents serious challenges to the successful treatment of staphylococcal infections of companion animals. OBJECTIVES: The objective of this document is to provide harmonized recommendations for the diagnosis, prevention and treatment of meticillin-resistant staphylococcal infections in dogs and cats...
June 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28516256/-skin-diseases-associated-with-environmental-factors
#11
REVIEW
Vera Mahler
BACKGROUND: Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease. OBJECTIVES: Provide an overview of non-allergic skin diseases associated with environmental factors. MATERIALS AND METHODS: Review of current scientific evidence for associations of non-allergic skin diseases with environmental exposures: irritation, chemicals, infection, UV-radiation, temperature. RESULTS: Predisposition (constitution e...
June 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28507497/sense-of-coherence-as-a-protective-factor-in-chronic-urticaria
#12
Alicja Ograczyk, Joanna Miniszewska, Anna Pietrzak, Anna Zalewska-Janowska
INTRODUCTION: Chronic urticaria (CU) seems to be perceived as a psychodermatological disorder. Different psychological factors play an important role in CU triggering and course. One of them is a sense of coherence (SOC), which is believed to be a protective factor against anxiety and depression. AIM: To investigate quality of life (QoL) in CU patients and to compare selected psychological parameters (anxiety, depression and sense of coherence) between CU individuals and the control group...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28492018/impact-of-leishmaniasis-in-women-a-practical-review-with-an-update-on-my-isd-supported-initiative-to-combat-leishmaniasis-in-yemen-elyp
#13
REVIEW
Mohamed A Al-Kamel
Stigma is synonymous with leishmaniasis, an endemic deadly flesh-eating disease in Yemen that affects predominantly poor rural women and children. Women with leishmaniasis often present late and experience not only physical deformities and the risk of death, but also the painful stigma of the disease and its consequences, a similar situation to that of leprosy decades ago. The International Society of Dermatology-sponsored community dermatology project Eradication of Leishmaniasis from Yemen Project has made a difference in the leishmaniasis situation in Yemen and addressed its magnitude...
September 2016: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28485036/severity-strata-for-easi-measi-oscorad-scorad-adsi-and-bsa-in-adolescents-and-adults-with-atopic-dermatitis
#14
R Chopra, P P Vakharia, R Sacotte, N Patel, S Immaneni, T White, R Kantor, D Y Hsu, J I Silverberg
BACKGROUND: Scoring systems for assessing the signs of atopic dermatitis (AD) are complex and difficult to interpret. Severity strata are helpful to properly interpret these assessments. We sought to confirm previously reported strata for Eczema Area and Severity Index (EASI), Scoring AD (SCORAD) and objective component of SCORAD (oSCORAD) and develop strata for the modified EASI (mEASI), Atopic Dermatitis Severity Index (ADSI) and body surface (BSA) for use in adults with AD. METHODS: Skin-examination was performed in 673 adolescents and adults (age ≥13 years) with diagnosed AD in a dermatology practice setting...
May 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28442804/clinico-epidemiological-profile-of-patients-attending-suraksha-clinic-of-tertiary-care-hospital-of-north-india
#15
H S Banger, Anisha Sethi, Sita Malhotra, Suresh Kumar Malhotra, Tejinder Kaur
BACKGROUND: Sexually transmitted infections (STIs) are a global health problem. Trends of STIs vary from place to place depending on various epidemiological factors prevailing in that respective geographic area. AIMS AND OBJECTIVES: The present study was conducted to find the pattern and prevalence of different STIs out of total STI clinic attendees, to identify any change in the trend of STIs, various epidemiological factors, and behavior of individual diseases...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28411776/establishment-of-a-dermatology-global-health-outreach-and-residency-partnership-program-in-guatemala
#16
Jules B Lipoff, Neha Jariwala, Monica Paz, Rudolf R Roth
No abstract text is available yet for this article.
May 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28410445/integrative-skin-care-dermatology-and-traditional-and-complementary-medicine
#17
REVIEW
Gerard Bodeker, Terence J Ryan, Adva Volk, Jahnavi Harris, Gemma Burford
Skin problems and diseases are extremely common globally and, due to their visibility, often result in severe distress and stigma for sufferers. Traditional (i.e., indigenous or local) and complementary health systems are widely used and incorporate many treatment modalities suitable for skin care, and a body of evidence for their efficacy and safety has built up over many decades. These approaches are often used as part of a broader "integrative medicine" (IM) approach that may also include, for example, nutrition and mind-body approaches...
June 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28403267/the-current-state-of-dermatologists-familiarity-and-perspectives-of-biosimilars-for-the-treatment-of-psoriasis-a-global-cross-sectional-survey
#18
Iviensan F Manalo, Kathleen E Gilbert, Jashin J Wu
<p>BACKGROUND: Biologic patent expiration, accelerated approval pathways, and business interests of third party payers and the biopharmaceutical industry are driving the development of biosimilars to treat immune-mediated disorders like psoriasis. No studies have investigated dermatologists' familiarity and perspectives of biosimilars.</p> <p>OBJECTIVES: To assess: (1) dermatologists' familiarity with biosimilars and interchangeability and (2) their perspectives toward biosimilar properties, including interchangeability, indication extrapolation, and immunogenicity risk...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28401585/a-proposed-scoring-system-for-assessing-the-severity-of-actinic-keratosis-on-the-head-actinic-keratosis-area-and-severity-index
#19
T Dirschka, G Pellacani, G Micali, J Malvehy, A J Stratigos, A Casari, L Schmitz, G Gupta
BACKGROUND: Actinic keratosis (AK) severity is currently evaluated by subjective assessment of patients. OBJECTIVES: To develop and perform an initial pilot validation of a new easy-to-use quantitative tool for assessing AK severity on the head. METHODS: The actinic keratosis area and severity index (AKASI) for the head was developed based on a review of other severity scoring systems in dermatology, in particular the psoriasis area and severity index (PASI)...
April 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28346251/histological-mohs-maps-improve-the-accuracy-of-dermatology-residents-interpretations-of-mohs-slides-a-pilot-study
#20
Jeffrey B Tiger, Zai Ganesh, John Mouzakis, Satori Iwamoto
BACKGROUND: Effective Mohs surgery depends on accurate histopathological identification and mapping of tumor burden to ensure complete removal of tumor. OBJECTIVE: The purpose of this study is to evaluate whether using a photograph of the histopathological slide as the Mohs map improves mapping accuracy. METHODS AND MATERIALS: Single-blinded pilot study. Five dermatology residents at one academic institution mapped 11 cases of basal cell carcinoma using both traditional hand-drawn maps and color photographic maps...
March 23, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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