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https://www.readbyqxmd.com/read/28057360/efficacy-and-safety-of-guselkumab-an-anti-interleukin-23-monoclonal-antibody-compared-with-adalimumab-for-the-continuous-treatment-of-patients-with-moderate-to-severe-psoriasis-results-from-the-phase-iii-double-blinded-placebo-and-active-comparator-controlled
#1
Andrew Blauvelt, Kim A Papp, Christopher E M Griffiths, Bruce Randazzo, Yasmine Wasfi, Yaung-Kaung Shen, Shu Li, Alexa B Kimball
BACKGROUND: Guselkumab, an interleukin-23 blocker, was superior to adalimumab in treating moderate to severe psoriasis in a phase II trial. OBJECTIVES: We sought to compare efficacy and safety of guselkumab with adalimumab and placebo in patients with psoriasis treated for 1 year. METHODS: Patients were randomized to guselkumab 100 mg (weeks 0 and 4, then every 8 weeks; n = 329); placebo→guselkumab (weeks 0, 4, and 12 then guselkumab at weeks 16 and 20, then every 8 weeks; n = 174); or adalimumab (80 mg week 0, 40 mg week 1, then 40 mg every 2 weeks through week 47; n = 334)...
December 29, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28054351/hidradenitis-suppurativa-treated-with-tetracycline-in-combination-with-colchicine-a-prospective-series-of-20-patients
#2
Kalliopi Armyra, Anargyros Kouris, Vasiliki Markantoni, Andreas Katsambas, George Kontochristopoulos
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of the follicular epithelium. OBJECTIVES: The objective of the present study was to evaluate the effectiveness of the combination of tetracycline with colchicine in the treatment of HS. METHODS: Twenty patients (10 women and 10 men) with HS were included in an open, prospective, pilot study. All patients were treated with 100 mg minocycline administered orally once per day in combination with 0...
January 4, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27992140/impact-on-quality-of-life-of-alitretinoin-in-severe-chronic-hand-eczema-fugetta-real-world-study
#3
Matthias Augustin, Diamant Thaçi, Anja Kamps
BACKGROUND AND OBJECTIVES: Alitretinoin is the only approved treatment for severe chronic hand eczema (CHE) refractory to potent topical corticosteroids. This study (FUGETTA) evaluated the effectiveness and impact on quality of life (QoL) of oral alitretinoin in patients with severe refractory CHE in accordance with prescription guidelines. PATIENTS AND METHODS: Open-label, multicenter, noninterventional, observational study conducted in Germany. Patients were treated at their physician's discretion with once-daily alitretinoin 10 mg or 30 mg for a maximum of 24 weeks...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27992125/der-einfluss-von-alitretinoin-auf-die-lebensqualit%C3%A3-t-bei-patienten-mit-schwerem-chronischen-handekzem-fugetta-beobachtungsstudie-unter-praxisbedingungen
#4
Matthias Augustin, Diamant Thaçi, Anja Kamps
HINTERGRUND UND ZIELE: Alitretinoin ist die einzige zugelassene Behandlung für schweres chronisches Handekzem (CHE), das refraktär gegenüber potenten topischen Corticosteroiden ist. Bei dieser Studie (FUGETTA) wurde die Wirksamkeit von leitliniengerecht angewendetem oralem Alitretinoin sowie dessen Einfluss auf die Lebensqualität (LQ) bei Patienten mit schwerem refraktärem CHE beurteilt. PATIENTEN UND METHODEN: Multizentrische, offene, nichtinterventionelle Beobachtungsstudie, durchgeführt in Deutschland...
December 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27976465/determination-of-the-nail-psoriasis-severity-index-improvement-rate-standards-for-nail-psoriasis-treatment-in-a-phase-iv-clinical-trial-of-ustekinumab-the-marcopolo-study
#5
LETTER
S W Youn, B R Kim, S Cho, S J Seo, E S Lee, J Y Roh, G S Choi, M G Lee
No abstract text is available yet for this article.
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27938932/objective-structured-clinical-examination-as-an-assessment-tool-for-clinical-skills-in-dermatology
#6
D Saceda-Corralo, P Fonda-Pascual, Ó M Moreno-Arrones, A Alegre-Sánchez, Á Hermosa-Gelbard, N Jiménez-Gómez, S Vañó-Galván, P Jaén-Olasolo
BACKGROUND: Objective Structured Clinical Evaluation (OSCE) is an excellent method to evaluate student's abilities, but there are no previous reports implementing it in dermatology. OBJECTIVES: To determine the feasibility of implementation of a dermatology OSCE in the medical school. METHODS: Five stations with standardized patients and image-based assessment were designed. A specific checklist was elaborated in each station with different items which evaluated one competency and were classified into five groups (medical history, physical examination, technical skills, case management and prevention)...
December 6, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27909086/the-12-item-psoriatic-arthritis-impact-of-disease-questionnaire-construct-validity-reliability-and-interpretability-in-a-clinical-setting
#7
Marco Di Carlo, Andrea Becciolini, Valentina Lato, Chiara Crotti, Ennio Giulio Favalli, Fausto Salaffi
OBJECTIVE: To study, in a real-life setting, the construct validity, the reliability, and the interpretability of the 12-item Psoriatic Arthritis Impact of Disease (PsAID-12) questionnaire in patients with psoriatic arthritis (PsA). METHODS: In 144 consecutive patients with PsA (81 men and 63 women, mean age of 51.4 ± 12.8 yrs, and 77 receiving biologic treatment), the PsAID-12 and other patient-reported outcomes (PRO) were collected, such as the Dermatology Life Quality Index...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27885973/leprosy-trends-at-a-tertiary-care-hospital-in-mumbai-india-from-2008-to-2015
#8
Thirumugam Muthuvel, Petros Isaakidis, Hemant Deepak Shewade, Lucy Kattuppara, Rajbir Singh, Srinivas Govindarajulu
BACKGROUND: Leprosy remains an important cause of preventable disabilities. After the advent of multidrug therapy, new leprosy cases have come down dramatically. Despite this achievement, India, which contributes 60% of the global leprosy burden, faces some challenges to eliminate the disease, including active transmission in the community and delayed diagnosis of leprosy patients. OBJECTIVES: The objectives of the study were 1) to determine sociodemographic and clinical characteristics of newly diagnosed adults and children (less than 15 years) with leprosy and their trends over time (2008-2015) and 2) to describe the profile of surgical procedures among leprosy patients registered for reconstructive surgeries during 2006-2015...
2016: Global Health Action
https://www.readbyqxmd.com/read/27878060/a-retrospective-analysis-comparing-the-new-standardized-letter-of-recommendation-in-dermatology-with-the-classic-narrative-letter-of-recommendation
#9
Jessica A Kaffenberger, Joy Mosser, Grace Lee, Llana Pootrakul, Katya Harfmann, Stephanie Fabbro, Esteban Fernandez Faith, David Carr, Alisha Plotner, Matthew Zirwas, Benjamin H Kaffenberger
Background: In an effort to avoid numerous problems associated with narrative letters of recommendation, a dermatology standardized letter of recommendation was utilized in the 2014-2015 resident application cycle. Objective: A comparison of the standardized letter of recommendation and narrative letters of recommendation from a single institution and application cycle to determine if the standardized letter of recommendation met its original goals of efficiency, applicant stratification, and validity. Methods: Eight dermatologists assessed all standardized letters of recommendation/narrative letters of recommendation pairs received during the 2014-2015 application cycle...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27874885/patient-reported-outcomes-of-azelaic-acid-foam-15-for-patients-with-papulopustular-rosacea-secondary-efficacy-results-from-a-randomized-controlled-double-blind-phase-3-trial
#10
Stephen Tyring, James A Solomon, Gerald Staedtler, Jason P Lott, Richard Nkulikiyinka, Kaweh Shakery
Patient-reported treatment outcomes are important for evaluating the impact of drug therapies on patient experience. A randomized, double-blind, vehicle-controlled, parallel-group, multicenter, phase 3 study was conducted in 961 participants to assess patient perception of efficacy, utility, and effect on quality of life (QOL) of an azelaic acid (AzA) 15% foam formulation for the treatment of papulopustular rosacea (PPR). Secondary end points included patient-reported global assessment of treatment response, global assessment of tolerability, and opinion on cosmetic acceptability and practicability of product use...
October 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27828771/how-does-chronic-cigarette-smoke-exposure-affect-human-skin-a-global-proteomics-study-in-primary-human-keratinocytes
#11
Pavithra Rajagopalan, Vishalakshi Nanjappa, Remya Raja, Ankit P Jain, Kiran K Mangalaparthi, Gajanan J Sathe, Niraj Babu, Krishna Patel, Nükhet Cavusoglu, Jeremie Soeur, Akhilesh Pandey, Nita Roy, Lionel Breton, Aditi Chatterjee, Namita Misra, Harsha Gowda
Cigarette smoking has been associated with multiple negative effects on human skin. Long-term physiological effects of cigarette smoke are through chronic and not acute exposure. Molecular alterations due to chronic exposure to cigarette smoke remain unclear. Primary human skin keratinocytes chronically exposed to cigarette smoke condensate (CSC) showed a decreased wound-healing capacity with an increased expression of NRF2 and MMP9. Using quantitative proteomics, we identified 4728 proteins, of which 105 proteins were overexpressed (≥2-fold) and 41 proteins were downregulated (≤2-fold) in primary skin keratinocytes chronically exposed to CSC...
November 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27782026/a-review-and-critique-of-teledermatology-in-the-south-african-public-health-sector
#12
Laticha E M Walters, Maurice Mars, Richard E Scott
: Nearly 80% of the world's population live in developing countries in Asia, Africa, and Latin America. Many of these countries must face a triple or quadruple burden of disease with severely limited resources and health systems. South Africa (SA) is one such country, and recognises the potential for e-health to moderate these limitations. Dermatological issues remain a concern in SA and globally. Indeed, the World Health Organisation (WHO) has recognised that a number of diseases are most likely to manifest themselves through a dermatological problem before becoming full-blown...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27768196/correction-of-age-related-midface-volume-loss-with-low-volume-hyaluronic-acid-filler
#13
Monique Vanaman Wilson, Sabrina Guillen Fabi, Ryan Greene
Importance: The pivotal approval trial for a smooth, highly cohesive, viscous, 20-mg/mL hyaluronic acid filler demonstrated sustained aesthetic improvement, with a mean injection volume of 6.65 mL. In daily practice, however, it is not often practical or necessary to use large injection volumes to achieve the desired cosmetic outcome. Objective: To assess the efficacy, longevity, and patient satisfaction associated with correction of age-related midface volume loss using the low volumes of hyaluronic acid filler more commonly used in day-to-day practice...
October 20, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27742168/is-speed-of-healing-a-good-predictor-of-eventual-healing-of-pyoderma-gangrenosum
#14
Sally R Wilkes, Hywel C Williams, Anthony D Ormerod, Fiona E Craig, Nicola Greenlaw, John Norrie, Eleanor J Mitchell, James M Mason, Kim S Thomas
BACKGROUND: Pyoderma gangrenosum is a rare inflammatory skin condition. Two prospective studies have evaluated treatments for pyoderma gangrenosum using a primary outcome of healing speed at 6 weeks. OBJECTIVE: Using data from both studies we assessed the predictive value of 3 early predictors for healing at 6 months: speed of healing, Investigator Global Assessment (IGA), and resolution of inflammation, recorded at 2 and 6 weeks. METHODS: Logistic regression models were applied and the effectiveness of the 3 measures was assessed through estimating the positive and negative predictive values and the area under the receiver operating characteristic curve...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27741336/bensal-hp-for-second-intention-healing-following-mohs-micrographic-surgery-or-shave-skin-biopsy-an-open-label-pilot-study
#15
Breanne Mordorski, Adam J Friedman, Leon H Kircik
Dermatologists frequently create cutaneous defects that heal by second intention, yet there is no universal protocol for wound care in this setting. Several ointments commonly used for wound healing are not cost effective as they contain known contact allergens, contribute to antimicrobial resistance, and do not enhance the healing process. Recent studies indicate that Bensal HP, a commercially available ointment used for a variety of dermatologic conditions, may be useful for wound healing; although clinical data is currently limited...
October 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27732588/preclinical-study-of-single-dose-moxidectin-a-new-oral-treatment-for-scabies-efficacy-safety-and-pharmacokinetics-compared-to-two-dose-ivermectin-in-a-porcine-model
#16
Charlotte Bernigaud, Fang Fang, Katja Fischer, Anne Lespine, Ludwig Serge Aho, Dominique Dreau, Andrew Kelly, Jean-François Sutra, Francis Moreau, Thomas Lilin, Françoise Botterel, Jacques Guillot, Olivier Chosidow
BACKGROUND: Scabies is one of the commonest dermatological conditions globally; however it is a largely underexplored and truly neglected infectious disease. Foremost, improvement in the management of this public health burden is imperative. Current treatments with topical agents and/or oral ivermectin (IVM) are insufficient and drug resistance is emerging. Moxidectin (MOX), with more advantageous pharmacological profiles may be a promising alternative. METHODOLOGY/PRINCIPAL FINDINGS: Using a porcine scabies model, 12 pigs were randomly assigned to receive orally either MOX (0...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27707593/secukinumab-shows-significant-efficacy-in-palmoplantar-psoriasis-results-from-gesture-a-randomized-controlled-trial
#17
Alice Gottlieb, John Sullivan, Martijn van Doorn, Alexey Kubanov, Ruquan You, Anne Parneix, Sophie Hugot, Marina Milutinovic
BACKGROUND: Plaque psoriasis affecting palms and soles is disabling and often resistant to treatment. OBJECTIVE: Evaluate the efficacy and safety of secukinumab, an anti-interleukin 17A antibody, in subjects with palmoplantar psoriasis. METHODS: In this double-blinded, randomized controlled trial, 205 subjects were randomized 1:1:1 to secukinumab 300 mg, 150 mg, or placebo. The primary endpoint was Palmoplantar Investigator's Global Assessment (ppIGA) 0 (clear) or 1 (almost clear/minimal) response at week 16...
January 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27696381/climate-change-and-the-epidemiology-of-selected-tick-borne-and-mosquito-borne-diseases-update-from-the-international-society-of-dermatology-climate-change-task-force
#18
Louise K Andersen, Mark D P Davis
Climate change refers to variation in the climate of a specific region or globally over time. A change has been reported in the epidemiology of tick- and mosquito-borne diseases in recent decades. Investigators have postulated that this effect may be associated with climate change. We reviewed the English-language literature describing changes in the epidemiology of specific tick- and mosquito-borne diseases, including the tick-borne diseases of Lyme disease, tularemia, Crimean-Congo hemorrhagic fever, Mediterranean spotted fever, and Rocky Mountain spotted fever and the mosquito-borne diseases of dengue, malaria, West Nile virus infection, Ross River virus disease, and Barmah Forest virus disease...
October 1, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27695864/acta-dermatovenerologica-alpina-pannonica-et-adriatica-accepted-for-coverage-in-thomson-reuters-emerging-sources-citation-index-esci
#19
Mario Poljak, Jovan Miljković, Tina Triglav
Acta Dermatovenerologica Alpina, Pannonica et Adriatica (Acta Dermatovenerol APA) is the leading journal in dermatology and sexually transmitted infections in the region. Several important steps were taken during the last 25 years to improve the journal's quality, global visibility, and international impact. After a 1-year trial period, Thomson Reuters recently informed the editorial office that they had accepted Acta Dermatovenerol APA for coverage in Thomson Reuters' new index in the Web of Science Core Collection called the Emerging Sources Citation Index (ESCI)...
September 2016: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/27692733/tofacitinib-improves-pruritus-and-health-related-quality-of-life-up-to-52%C3%A2-weeks-results-from-2-randomized-phase-iii-trials-in-patients-with-moderate-to-severe-plaque-psoriasis
#20
Steven R Feldman, Diamant Thaçi, Melinda Gooderham, Matthias Augustin, Claudia de la Cruz, Lotus Mallbris, Marjorie Buonanno, Svitlana Tatulych, Mandeep Kaur, Shuping Lan, Hernan Valdez, Carla Mamolo
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor that improves clinical measures of psoriasis. OBJECTIVE: We sought to assess patient-reported outcomes in tofacitinib-treated patients with moderate to severe plaque psoriasis over 52 weeks. METHODS: In 2 identical, phase III studies (Oral treatment for Psoriasis Trial Pivotal 1 [NCT01276639], n = 901, and Pivotal 2 [NCT01309737], n = 960), patients were randomized 2:2:1 to receive 5 or 10 mg of tofacitinib or placebo, twice daily...
December 2016: Journal of the American Academy of Dermatology
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