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https://www.readbyqxmd.com/read/29108792/comparison-of-the-primary-stability-of-a-porous-coated-acetabular-revision-cup-with-a-standard-cup
#1
Nicholas A Beckmann, Sebastian Jaeger, Maciej B Janoszka, Matthias C Klotz, Thomas Bruckner, Rudi G Bitsch
BACKGROUND: The number of revision hip arthroplasty procedures has been increasing substantially, with the acetabular component requiring component revision in over half of the cases. New porous implant designs attempt to improve outcomes due to improved osseointegration; however, sufficient primary stability is paramount for good osseointegration. METHODS: We compared 2 revision cups of the same geometry, yet different surface properties in an in vitro scenario: a porous titanium surface and a conventional sintered-bead titanium surface...
September 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29080252/clinical-evaluation-of-tavocept-to-decrease-diuresis-time-and-volume-in-dogs-with-bladder-cancer-receiving-cisplatin
#2
C J Henry, B K Flesner, S A Bechtel, J N Bryan, D J Tate, K A Selting, J C Lattimer, M E Bryan, L Grubb, F Hausheer
BACKGROUND: Transitional cell carcinoma is the most common bladder cancer of dogs. Cisplatin combined with piroxicam provides superior response rates, but unacceptable rates of nephrotoxicity. Tavocept is a chemoprotectant that has mitigated cisplatin toxicity and decreased the required infusion/diuresis volume in clinical trials in humans. HYPOTHESIS/OBJECTIVES: We hypothesized that Tavocept would decrease diuresis volume and time and facilitate safe administration of a cisplatin/piroxicam protocol to dogs with bladder cancer...
October 27, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29067083/the-long-term-prognosis-of-epilepsy-patients-with-medically-treated-over-a-period-of-eight-years-in-turkey
#3
Pelin Duman, Asuman Orhan Varoglu, Esra Kurum
OBJECTIVE: The aim of this study was to investigate the effect of demographic and clinical characteristics on temporal changes in seizure control and frequency in medically treated epilepsy patients to guide treatment modalities. METHODS: We retrospectively analyzed the association between clinical and demographic characteristics and seizure frequency in 1329 epilepsy patients who were followed up at an outpatient clinic for one to eight years, 2008-2015.. RESULTS: Younger age at first seizure (p = 0...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29052094/severe-physical-complications-among-survivors-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#4
Cristina Olteanu, Neil H Shear, Hall F Chew, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Michael Ziv, Shachar Sade, Marc G Jeschke, Roni P Dodiuk-Gad
INTRODUCTION: Few studies have reported the physical complications among Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) survivors. OBJECTIVE: The aim of this study was to comprehensively characterize the physical complications among SJS/TEN survivors and to learn about patients' perspectives of surviving SJS/TEN. METHODS: SJS/TEN survivors older than 18 years of age were assessed by different methods: a medical interview; a questionnaire assessing patients' perspectives; thorough skin, oral mucous membrane, and ophthalmic examinations; and a retrospective assessment of medical records...
October 19, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29045029/the-immunosuppressant-brasilicardin-determination-of-the-biosynthetic-gene-cluster-in-the-heterologous-host-amycolatopsis-japonicum
#5
Paul N Schwarz, Anina Buchmann, Luisa Roller, Andreas Kulik, Harald Gross, Wolfgang Wohlleben, Evi Stegmann
Nocardia terpenica IFM 0406 is the producer of the immunosuppressants brasilicardins A-D. Brasilicardin is a promising compound because of its unique mode of action and its higher potency and reduced toxicity compared to today's standard drugs. However, production of brasilicardin was so far hampered since N. terpenica IFM 0406 synthesizes brasilicardin in only low amounts and represents a human pathogen (biosafety level 2 BSL2). In order to achieve a safe and high yield production of brasilicardin A (BraA) we heterologously expressed the brasilicardin gene cluster in the nocardioform actinomycete Amycolatopsis japonicum (A...
October 16, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29033041/short-term-venoarterial-extracorporeal-membrane-oxygenation-for-massive-endobronchial-hemorrhage-after-pulmonary-endarterectomy
#6
Stefan Guth, Christoph B Wiedenroth, Marc Wollenschläger, Manuel Jonas Richter, Hossein A Ghofrani, Matthias Arlt, Eckhard Mayer
OBJECTIVES: Pulmonary endarterectomy (PEA) is the only curative treatment option for patients with chronic thromboembolic pulmonary hypertension. Massive endobronchial bleeding that precludes weaning from cardiopulmonary bypass is an often-fatal complication of PEA. The aim of this study was to determine whether short-term extracorporeal membrane oxygenation (ECMO) is a safe and feasible procedure in patients with severe endobronchial bleeding. METHODS: From January 2014 to December 2016, 396 patients (mean age 60 ± 18 years, 54...
September 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29021437/a-systematic-review-of-the-effectiveness-of-antianxiety-and-antidepressive-agents-for-functional-dyspepsia
#7
Mariko Hojo, Akihito Nagahara, Daisuke Asaoka, Yuji Shimada, Sasaki Hitoshi, Kohei Matsumoto, Tsutomu Takeda, Hiroya Ueyama, Kenshi Matsumoto, Sumio Watanabe
Background and Aim Functional dyspepsia (FD) is defined as persistent or recurrent pain or discomfort centered in the upper abdomen without organic disease. Psychosocial factors have been proposed as an important element in the pathophysiology of FD. Therefore, psychotropic agents having antianxiety or antidepressive action are expected to alleviate FD. We previously reported on the treatment of FD using such agents in a systematic review, wherein the effectiveness of the agents on FD was suggested, although there were several limitations...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28902578/associations-between-the-hla-a-b-drb1-polymorphisms-and-aplastic-anemia-evidence-from-17-case-control-studies
#8
Xiao-Zhen Deng, Meng Du, Jiao Peng, Jian-Xiong Long, Cheng-Jun Zheng, Yuan Tan, Li-Juan Li, Hui-Ying Chen, Cao Qing, Yan-Yan Pang, Yan Lan, Hai-Tian Zhang
OBJECTIVE: To estimate the associations between HLA-A/B/DRB1 polymorphisms and aplastic anemia (AA), we carried out the meta-analysis. METHODS: In this meta-analysis, all publications in English and Chinese were considered up to 30 September 2015. The electronic databases we searched were Pubmed, Science Direct, Embase, Web of Science, CNKI, Wanfang Data and VIP. We conducted all statistical data analyses in the Stata11.0 software. RESULTS: A total of 17 studies including 9164 subjects (containing 1372 cases and 7792 controls) were retrieved, which studied the relationship between HLA-A/B/DRB1 and AA...
September 13, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28811859/long-term-effect-of-alogliptin-on-glycemic-control-in-japanese-patients-with-type-2-diabetes-a-3-5-year-observational-study
#9
Kohzo Takebayashi, Tatsuhiko Suzuki, Rika Naruse, Kenji Hara, Mariko Suetsugu, Takafumi Tsuchiya, Toshihiko Inukai
BACKGROUND: The goal of the current study was to investigate the long-term effects (after 3 years or more) of alogliptin on glycemic control in Japanese patients with type 2 diabetes. METHODS: We retrospectively studied the effect of alogliptin on glycemic control in the patients with type 2 diabetes who had participated in our previous 3-month study and who continued to take alogliptin for at least 36 months. RESULTS: The mean duration of alogliptin treatment was 42...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28771005/inhibition-mechanisms-of-a-pyridazine-based-amyloid-inhibitor-as-a-%C3%AE-sheet-destabilizer-and-a-helix-bridge-maker
#10
Hamid R Kalhor, M Parsa Jabbari
Conformational diseases have been investigated extensively in recent years; as a result, a number of drug candidates have been introduced as amyloid inhibitors; however, no effective therapies have been put forward. RS-0406 with pyridazine as its core chemical structure has so far shown promising results in inhibiting amyloid formation. In the present work, using molecular dynamics, we undertook the investigation of RS-0406 interactions with U-shaped Aβ1-42 and Aβ1-40 pentamers, Aβ1-42 monomers, and double-horseshoe-like Aβ1-42...
August 3, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28699263/predictors-of-early-continence-after-robot-assisted-radical-prostatectomy
#11
Yuta Yamada, Tetsuya Fujimura, Hiroshi Fukuhara, Toru Sugihara, Tohru Nakagawa, Haruki Kume, Yasuhiko Igawa, Yukio Homma
OBJECTIVE: Our objective was to investigate predictors of early continence outcome after robot-assisted radical prostatectomy (RARP). METHODS: Clinical records were prospectively collected in 272 patients who underwent RARP. Clinical parameters, continence rates, and time to achieve continence were investigated and analyzed. Recovery of continence was defined as achieving complete continence (pad-free). RESULTS: In the univariate analysis, young age (≤67 years) and low pT stage (≤pT2) were significantly associated with continence achieved within 2 weeks after RARP (P = 0...
July 11, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28614380/interleukin-34-inhibits-hepatitis-b-virus-replication-in-vitro-and-in-vivo
#12
Sheng-Tao Cheng, Hua Tang, Ji-Hua Ren, Xiang Chen, Ai-Long Huang, Juan Chen
BACKGROUND: The hepatitis B virus (HBV) infection could activate the immune system and induce extensive inflammatory response. As the most important inflammatory factor, interleukins are critical for anti-viral immunity. Here we investigated whether interleukin-34 (IL-34) play a role in HBV infection. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we first found that both serum IL-34 and IL-34 mRNA in PBMCs in chronic HBV patients was significantly decreased compared to the healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28226184/cd117-kit-is-a-useful-marker-in-the-diagnosis-of-plasmablastic-plasma-cell-myeloma
#13
Etan Marks, Yang Shi, Yanhua Wang
AIMS: Plasmablastic plasma cell myeloma (PPCM) is a rare morphological presentation of multiple myeloma, and can resemble plasmablastic lymphoma (PBL), a human immunodeficiency virus (HIV)-related lymphoid neoplasm, morphologically and immunophenotypically. The aim of this study was to retrospectively search for factors that could help to differentiate these two entities. METHODS AND RESULTS: We used clinical looking glass, a data mining tool, to identify patients with a diagnosis of either PPCM or PBL with a CD117 test performed...
July 2017: Histopathology
https://www.readbyqxmd.com/read/28196659/sutures-impregnated-with-carbazate-activated-polyvinyl-alcohol-reduce-intraperitoneal-adhesions
#14
F Fredriksson, F Sellberg, T Bowden, T Engstrand, D Berglund, H E Lilja
BACKGROUND: Intraperitoneal adhesions cause significant morbidity. They occur after peritoneal trauma, which induces oxidative stress with production of inflammatory cytokines, peroxidized proteins (carbonyls) and lipids (aldehydes). This study aimed to investigate if carbazate-activated polyvinyl alcohol (PVAC), an aldehyde-carbonyl inhibitor, can reduce intraperitoneal adhesions in an experimental model. MATERIAL AND METHODS: Male Sprague-Dawley rats (n=110) underwent laparotomy, cecal abrasion and construction of a small bowel anastomosis...
November 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28127808/a-randomized-controlled-trial-of-brief-interventions-to-reduce-drug-use-among-adults-in-a-low-income-urban-emergency-department-the-healthier-you-study
#15
Frederic C Blow, Maureen A Walton, Amy S B Bohnert, Rosalinda V Ignacio, Stephen Chermack, Rebecca M Cunningham, Brenda M Booth, Mark Ilgen, Kristen L Barry
AIMS: To examine efficacy of drug brief interventions (BIs) among adults presenting to a low-income urban emergency department (ED). DESIGN: Randomized controlled trial on drug use outcomes at 3, 6 and 12 months. Participants were assigned to (1) computer-delivered BI (Computer BI), (2) therapist-delivered, computer-guided BI (Therapist BI) or (3) enhanced usual care (EUC-ED) for drug-using adults. Participants were re-randomized after the 3-month assessment to either adapted motivational enhancement therapy (AMET) booster or enhanced usual care booster (EUC-B)...
January 26, 2017: Addiction
https://www.readbyqxmd.com/read/28115032/hybrid-methodology-for-tuberculosis-incidence-time-series-forecasting-based-on-arima-and-a-nar-neural-network
#16
K W Wang, C Deng, J P Li, Y Y Zhang, X Y Li, M C Wu
Tuberculosis (TB) affects people globally and is being reconsidered as a serious public health problem in China. Reliable forecasting is useful for the prevention and control of TB. This study proposes a hybrid model combining autoregressive integrated moving average (ARIMA) with a nonlinear autoregressive (NAR) neural network for forecasting the incidence of TB from January 2007 to March 2016. Prediction performance was compared between the hybrid model and the ARIMA model. The best-fit hybrid model was combined with an ARIMA (3,1,0) × (0,1,1)12 and NAR neural network with four delays and 12 neurons in the hidden layer...
April 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28013570/polymorphisms-and-expression-of-toll-like-receptors-in-autoimmune-thyroid-diseases
#17
Naoya Inoue, Yuka Katsumata, Mikio Watanabe, Naoko Ishido, Yu Manabe, Ayano Watanabe, Ryota Masutani, Yoh Hidaka, Yoshinori Iwatani
Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production of proinflammatory cytokines. UNC93B1 is a transcription factor of TLR7 and TLR9. In this study, we examined the association of TLR expression and TLR and UNC93B1 polymorphisms with the development and prognosis of AITDs. The ratio of intracellular TLR7 (iTLR7) and iTLR9 intensities in B cells was lower in patients with GD in remission than in patients with intractable GD (p = 0...
December 26, 2016: Autoimmunity
https://www.readbyqxmd.com/read/27979943/high-quality-draft-genome-sequence-of-the-actinobacterium-nocardia-terpenica-ifm-0406-producer-of-the-immunosuppressant-brasilicardins-using-illumina-and-pacbio-technologies
#18
Anina Buchmann, Michael Eitel, Pierre Koch, Paul N Schwarz, Evi Stegmann, Wolfgang Wohlleben, Marcin Wolański, Michał Krawiec, Jolanta Zakrzewska-Czerwińska, Carmen Méndez, Alma Botas, Luz Elena Núñez, Francisco Morís, Jesus Cortés, Harald Gross
The bacterium Nocardia terpenica IFM 0406 is known as the producer of the immunosuppressant brasilicardin A. Here, we report the completely sequenced genome of strain IFM 0406, which facilitates the heterologous expression of the brasilicardin biosynthetic gene cluster but also unveils the intriguing biosynthetic capacity of the strain to produce secondary metabolites.
December 15, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27892594/chloroprocaine-10-mg-ml-for-low-dose-spinal-anaesthesia-in-perianal-surgery-a-randomised-dose-finding-study
#19
RANDOMIZED CONTROLLED TRIAL
V Gebhardt, L Mueller-Hansen, A Schwarz, D Bussen, C Weiss, M D Schmittner
BACKGROUND: Low-dose spinal anaesthesia is a safe and reliable anaesthesia technique in outpatient perianal surgery. Regarding its short duration of action and its trend to hyperbaric characteristics, plain chloroprocaine 10 mg/ml seems to be ideal to perform low-dose spinal anaesthesia. The aim of this trial was to determine the optimal dosage of chloroprocaine for this indication. METHODS: Hundred and twenty patients undergoing perianal surgery were enrolled and randomly allocated to receive 10, 20 or 30 mg of chloroprocaine 10 mg/ml intrathecally...
February 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27565715/immunogenicity-of-trimethoprim-sulfamethoxazole-in-a-macaque-model-of-hiv-infection
#20
Yat Yee Wong, Eva G Rakasz, David J Gasper, Thomas C Friedrich, Lauren A Trepanier
BACKGROUND: Sulfonamide hypersensitivity has a high incidence in HIV infection and correlates with low CD4+ counts, but the mechanisms are not understood. The aims of this study were to determine whether trimethoprim/sulfamethoxazole (TMP/SMX) led to SMX adduct formation, immunogenicity, or signs of drug hypersensitivity in SIV-infected rhesus macaques, and whether differences in antioxidants, pro-inflammatory mediators, or SMX disposition were predictive of drug immunogenicity. METHODS: Nine macaques chronically infected with SIVmac239 and 7 non-infected controls were studied...
August 10, 2016: Toxicology
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