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https://www.readbyqxmd.com/read/28811859/long-term-effect-of-alogliptin-on-glycemic-control-in-japanese-patients-with-type-2-diabetes-a-3-5-year-observational-study
#1
Kohzo Takebayashi, Tatsuhiko Suzuki, Rika Naruse, Kenji Hara, Mariko Suetsugu, Takafumi Tsuchiya, Toshihiko Inukai
BACKGROUND: The goal of the current study was to investigate the long-term effects (after 3 years or more) of alogliptin on glycemic control in Japanese patients with type 2 diabetes. METHODS: We retrospectively studied the effect of alogliptin on glycemic control in the patients with type 2 diabetes who had participated in our previous 3-month study and who continued to take alogliptin for at least 36 months. RESULTS: The mean duration of alogliptin treatment was 42...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28771005/inhibition-mechanisms-of-a-pyridazine-based-amyloid-inhibitor-as-a-%C3%AE-sheet-destabilizer-and-a-helix-bridge-maker
#2
Hamid R Kalhor, M Parsa Jabbari
Conformational diseases have been investigated extensively in recent years; as a result, a number of drug candidates have been introduced as amyloid inhibitors; however, no effective therapies have been put forward. RS-0406 with pyridazine as its core chemical structure has so far shown promising results in inhibiting amyloid formation. In the present work, using molecular dynamics, we undertook the investigation of RS-0406 interactions with U-shaped Aβ1-42 and Aβ1-40 pentamers, Aβ1-42 monomers, and double-horseshoe-like Aβ1-42...
August 3, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28699263/predictors-of-early-continence-after-robot-assisted-radical-prostatectomy
#3
Yuta Yamada, Tetsuya Fujimura, Hiroshi Fukuhara, Toru Sugihara, Tohru Nakagawa, Haruki Kume, Yasuhiko Igawa, Yukio Homma
OBJECTIVE: Our objective was to investigate predictors of early continence outcome after robot-assisted radical prostatectomy (RARP). METHODS: Clinical records were prospectively collected in 272 patients who underwent RARP. Clinical parameters, continence rates, and time to achieve continence were investigated and analyzed. Recovery of continence was defined as achieving complete continence (pad-free). RESULTS: In the univariate analysis, young age (≤67 years) and low pT stage (≤pT2) were significantly associated with continence achieved within 2 weeks after RARP (P = 0...
July 11, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28614380/interleukin-34-inhibits-hepatitis-b-virus-replication-in-vitro-and-in-vivo
#4
Sheng-Tao Cheng, Hua Tang, Ji-Hua Ren, Xiang Chen, Ai-Long Huang, Juan Chen
BACKGROUND: The hepatitis B virus (HBV) infection could activate the immune system and induce extensive inflammatory response. As the most important inflammatory factor, interleukins are critical for anti-viral immunity. Here we investigated whether interleukin-34 (IL-34) play a role in HBV infection. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we first found that both serum IL-34 and IL-34 mRNA in PBMCs in chronic HBV patients was significantly decreased compared to the healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28226184/cd117-kit-is-a-useful-marker-in-the-diagnosis-of-plasmablastic-plasma-cell-myeloma
#5
Etan Marks, Yang Shi, Yanhua Wang
AIMS: Plasmablastic plasma cell myeloma (PPCM) is a rare morphological presentation of multiple myeloma, and can resemble plasmablastic lymphoma (PBL), a human immunodeficiency virus (HIV)-related lymphoid neoplasm, morphologically and immunophenotypically. The aim of this study was to retrospectively search for factors that could help to differentiate these two entities. METHODS AND RESULTS: We used clinical looking glass, a data mining tool, to identify patients with a diagnosis of either PPCM or PBL with a CD117 test performed...
July 2017: Histopathology
https://www.readbyqxmd.com/read/28196659/sutures-impregnated-with-carbazate-activated-polyvinyl-alcohol-reduce-intraperitoneal-adhesions
#6
F Fredriksson, F Sellberg, T Bowden, T Engstrand, D Berglund, H E Lilja
BACKGROUND: Intraperitoneal adhesions cause significant morbidity. They occur after peritoneal trauma, which induces oxidative stress with production of inflammatory cytokines, peroxidized proteins (carbonyls) and lipids (aldehydes). This study aimed to investigate if carbazate-activated polyvinyl alcohol (PVAC), an aldehyde-carbonyl inhibitor, can reduce intraperitoneal adhesions in an experimental model. MATERIAL AND METHODS: Male Sprague-Dawley rats (n=110) underwent laparotomy, cecal abrasion and construction of a small bowel anastomosis...
February 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28127808/a-randomized-controlled-trial-of-brief-interventions-to-reduce-drug-use-among-adults-in-a-low-income-urban-emergency-department-the-healthier-you-study
#7
Frederic C Blow, Maureen A Walton, Amy S B Bohnert, Rosalinda V Ignacio, Stephen Chermack, Rebecca M Cunningham, Brenda M Booth, Mark Ilgen, Kristen L Barry
AIMS: To examine efficacy of drug brief interventions (BIs) among adults presenting to a low-income urban emergency department (ED). DESIGN: Randomized controlled trial on drug use outcomes at 3, 6 and 12 months. Participants were assigned to (1) computer-delivered BI (Computer BI), (2) therapist-delivered, computer-guided BI (Therapist BI) or (3) enhanced usual care (EUC-ED) for drug-using adults. Participants were re-randomized after the 3-month assessment to either adapted motivational enhancement therapy (AMET) booster or enhanced usual care booster (EUC-B)...
January 26, 2017: Addiction
https://www.readbyqxmd.com/read/28115032/hybrid-methodology-for-tuberculosis-incidence-time-series-forecasting-based-on-arima-and-a-nar-neural-network
#8
K W Wang, C Deng, J P Li, Y Y Zhang, X Y Li, M C Wu
Tuberculosis (TB) affects people globally and is being reconsidered as a serious public health problem in China. Reliable forecasting is useful for the prevention and control of TB. This study proposes a hybrid model combining autoregressive integrated moving average (ARIMA) with a nonlinear autoregressive (NAR) neural network for forecasting the incidence of TB from January 2007 to March 2016. Prediction performance was compared between the hybrid model and the ARIMA model. The best-fit hybrid model was combined with an ARIMA (3,1,0) × (0,1,1)12 and NAR neural network with four delays and 12 neurons in the hidden layer...
April 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28013570/polymorphisms-and-expression-of-toll-like-receptors-in-autoimmune-thyroid-diseases
#9
Naoya Inoue, Yuka Katsumata, Mikio Watanabe, Naoko Ishido, Yu Manabe, Ayano Watanabe, Ryota Masutani, Yoh Hidaka, Yoshinori Iwatani
Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production of proinflammatory cytokines. UNC93B1 is a transcription factor of TLR7 and TLR9. In this study, we examined the association of TLR expression and TLR and UNC93B1 polymorphisms with the development and prognosis of AITDs. The ratio of intracellular TLR7 (iTLR7) and iTLR9 intensities in B cells was lower in patients with GD in remission than in patients with intractable GD (p = 0...
December 26, 2016: Autoimmunity
https://www.readbyqxmd.com/read/27979943/high-quality-draft-genome-sequence-of-the-actinobacterium-nocardia-terpenica-ifm-0406-producer-of-the-immunosuppressant-brasilicardins-using-illumina-and-pacbio-technologies
#10
Anina Buchmann, Michael Eitel, Pierre Koch, Paul N Schwarz, Evi Stegmann, Wolfgang Wohlleben, Marcin Wolański, Michał Krawiec, Jolanta Zakrzewska-Czerwińska, Carmen Méndez, Alma Botas, Luz Elena Núñez, Francisco Morís, Jesus Cortés, Harald Gross
The bacterium Nocardia terpenica IFM 0406 is known as the producer of the immunosuppressant brasilicardin A. Here, we report the completely sequenced genome of strain IFM 0406, which facilitates the heterologous expression of the brasilicardin biosynthetic gene cluster but also unveils the intriguing biosynthetic capacity of the strain to produce secondary metabolites.
December 15, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27892594/chloroprocaine-10-mg-ml-for-low-dose-spinal-anaesthesia-in-perianal-surgery-a-randomised-dose-finding-study
#11
RANDOMIZED CONTROLLED TRIAL
V Gebhardt, L Mueller-Hansen, A Schwarz, D Bussen, C Weiss, M D Schmittner
BACKGROUND: Low-dose spinal anaesthesia is a safe and reliable anaesthesia technique in outpatient perianal surgery. Regarding its short duration of action and its trend to hyperbaric characteristics, plain chloroprocaine 10 mg/ml seems to be ideal to perform low-dose spinal anaesthesia. The aim of this trial was to determine the optimal dosage of chloroprocaine for this indication. METHODS: Hundred and twenty patients undergoing perianal surgery were enrolled and randomly allocated to receive 10, 20 or 30 mg of chloroprocaine 10 mg/ml intrathecally...
February 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27565715/immunogenicity-of-trimethoprim-sulfamethoxazole-in-a-macaque-model-of-hiv-infection
#12
Yat Yee Wong, Eva G Rakasz, David J Gasper, Thomas C Friedrich, Lauren A Trepanier
BACKGROUND: Sulfonamide hypersensitivity has a high incidence in HIV infection and correlates with low CD4+ counts, but the mechanisms are not understood. The aims of this study were to determine whether trimethoprim/sulfamethoxazole (TMP/SMX) led to SMX adduct formation, immunogenicity, or signs of drug hypersensitivity in SIV-infected rhesus macaques, and whether differences in antioxidants, pro-inflammatory mediators, or SMX disposition were predictive of drug immunogenicity. METHODS: Nine macaques chronically infected with SIVmac239 and 7 non-infected controls were studied...
August 10, 2016: Toxicology
https://www.readbyqxmd.com/read/27508625/-op-2b-06-renal-resistive-index-and-pulse-pressure-at-3-months-have-a-different-impact-on-long-term-risk-of-death-and-graft-loss-in-renal-transplantation
#13
J-M Halimi, L Vernier, P Gatault, C Barbet, J Roumy, J Marliere, H Longuet, E Merieau, B Sautenet, C Baron, M Buchler
OBJECTIVE: Some studies suggest that pulse pressure (PP) and renal resistive index (RI) could be predictive of the risk of death; however, whether they also predict graft loss is debated. It was recently demonstrated that RI reflects large artery arterial stiffness as PP does but RI is also affected by alteration in renal microcirculation alteration. Finally, the respective predictive value of these 2 parameters considered together on graft loss and death is unknown. DESIGN AND METHOD: Cohort study of consecutive patients who received a renal graft in Tours from 1985 to 2014 in whom PP and RI were measured at 3 months...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27366714/glycemic-control-and-pregnancy-outcomes-in-patients-with-diabetes-in-pregnancy-a-retrospective-study
#14
Badurudeen Mahmood Buhary, Ohoud Almohareb, Naji Aljohani, Saad H Alzahrani, Samer Elkaissi, Suphia Sherbeeni, Abdulrahman Almaghamsi, Mussa Almalki
CONTEXT: Diabetes in pregnancy (DIP) is either pregestational or gestational. AIMS: To determine the relationship between glycemic control and pregnancy outcomes in a cohort of DIP patients. SETTINGS AND DESIGN: In this 12-month retrospective study, a total of 325 Saudi women with DIP who attended the outpatient clinics at a tertiary center Riyadh, Saudi Arabia, were included. SUBJECTS AND METHODS: The patients were divided into two groups, those with glycated hemoglobin (HbA1c) ≤6...
July 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27209616/sealing-effect-of-cross-linked-gelatin-glue-in-the-rat-lung-air-leak-model
#15
Norikazu Kawai, Shuko Suzuki, Hiroshi Naito, Keiji Kushibe, Takashi Tojo, Yoshito Ikada, Shigeki Taniguchi
BACKGROUND: Air leak is a common problem in pulmonary surgical procedures. In this study, we evaluated the efficacy and safety of gelatin glue (cross-linked with glutaraldehyde) in a rat model of lung air leak. METHODS: A model of pulmonary fistula was created in the rat lung with the use of a needle. The fistula was then sealed with either gelatin glue (group A), fibrin glue (group B), or fibrin glue with a polyglycolic acid sheet (group C). The seal breaking pressures were measured for each group, and the results were compared...
July 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27161723/po-36-thrombin-inhibition-preoperatively-tip-in-early-breast-cancer-the-first-clinical-trial-of-noacs-as-an-anti-cancer-agent-trial-methodology
#16
C C Kirwan, N J Bundred, J Castle, R Clarke, C Dive, J Morris, C Holcombe, J R Harvey
INTRODUCTION: Breast cancer is associated with a 3-4 fold increased risk of VTE. These patients have a 4-fold lower survival than those remaining free of VTE, implying VTE is a surrogate marker for aggressive cancer. Tumour expression of thrombin pathway markers are increased in the oestrogen receptor negative (ER-), high Ki67, more aggressive breast cancer subtypes. In in vitro and in vivo studies, the thrombin pathway promotes cancer growth and metastases, highlighting the potential role of the thrombin pathway as a therapeutic target in cancer...
April 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27133942/impact-of-radius-malunion-on-wrist-contact-mechanics
#17
Emily A Lalone, Ruby Grewal, Joy C MacDermid
The patient was a 15-year-old adolescent girl with a chief complaint of intermittent pain and clicking at her right distal radioulnar joint, after having fractured her forearm 5 months previously. Radiographs of the patient's forearm indicated a midshaft radial deformity. Given the patient's pain and limited range of motion, computed tomography imaging was requested to assess whether the midshaft malunion resulted in distal radioulnar joint instability and to plan the corrective osteotomy. J Orthop Sports Phys Ther 2016;46(5):399...
May 2016: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27102733/recurrences-in-stage-ii-rectal-carcinoma-after-curative-resection-alone-from-the-viewpoint-of-angiogenesis
#18
Željko Martinović, Dražen Kovač, Cvita Martinović
BACKGROUND: Angiogenesis plays a pivotal role in malignant tumor progression. The count of blood microvessels of the tumor has been recognized as an indicator of malignant potential of the tumors and provides the ability to predict tumors recurrence. The role endoglin in the Dukes B rectal cancer is still unexplored. The aims of this study were to examine immunohistochemical expression of endoglin in resected rectal cancer and investigate the relationship of tumor recurrence and other clinicopathological variables to the endoglin-assessed microvessel density of the tumor tissue and distal resection margins...
April 22, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26877293/co-39-pulse-pressure-and-renal-resistive-index-at-3-months-following-transplantation-differentially-affect-long-term-risk-of-death-and-graft-loss
#19
J M Halimi, L Vernier, P Gatault, C Barbet, J Roumy, J Marliere, H Longuet, E Merieau, B Sautenet, C Baron, M Buchler
OBJECTIFS: Certaines études ont suggéré que la pression pulsée (PP) et l'index de résistance intra-rénale (IR) pouvaient être prédictifs du risque de décès, mais leur impact sur la survie du greffon est controversé. Il a été montré que l'IR était un reflet de la rigidité artérielle des gros vaisseaux comme la PP, mais aussi de l'état de la microcirculation rénale. Cependant, l'impact respectif de ces 2 paramètres sur les risques de décès et de perte de greffon n'est pas connu, et a été l'objet de cette étude...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26845581/simultaneous-detection-of-trace-metal-ions-in-water-by-solid-phase-extraction-spectroscopy-combined-with-multivariate-calibration
#20
Lei Wang, Peng Cao, Wei Li, Peijin Tong, Xiaofang Zhang, Yiping Du
Solid Phase Extraction Spectroscopy (SPES) developed in this paper is a technique to measure spectrum directly on the solid phase material where the analytes are concentrated in SPE process. Membrane enrichment and UV-Visible spectroscopy were utilized to fulfill SPES, and multivariate calibration method of partial least squares (PLS) was used to simultaneously detect the concentrations of trace cobalt (II) and zinc (II) in water samples. The proposed method is simple, sensitive and selective. The complexes of analyte ions were collected on the cellulose acetate membranes via membrane filtration after the complexation reaction with 1-2-pyridylazo 2-naphthol (PAN)...
April 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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