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Naoya Inoue, Yuka Katsumata, Mikio Watanabe, Naoko Ishido, Yu Manabe, Ayano Watanabe, Ryota Masutani, Yoh Hidaka, Yoshinori Iwatani
Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production of proinflammatory cytokines. UNC93B1 is a transcription factor of TLR7 and TLR9. In this study, we examined the association of TLR expression and TLR and UNC93B1 polymorphisms with the development and prognosis of AITDs. The ratio of intracellular TLR7 (iTLR7) and iTLR9 intensities in B cells was lower in patients with GD in remission than in patients with intractable GD (p = 0...
December 26, 2016: Autoimmunity
Anina Buchmann, Michael Eitel, Pierre Koch, Paul N Schwarz, Evi Stegmann, Wolfgang Wohlleben, Marcin Wolański, Michał Krawiec, Jolanta Zakrzewska-Czerwińska, Carmen Méndez, Alma Botas, Luz Elena Núñez, Francisco Morís, Jesus Cortés, Harald Gross
The bacterium Nocardia terpenica IFM 0406 is known as the producer of the immunosuppressant brasilicardin A. Here, we report the completely sequenced genome of strain IFM 0406, which facilitates the heterologous expression of the brasilicardin biosynthetic gene cluster but also unveils the intriguing biosynthetic capacity of the strain to produce secondary metabolites.
December 15, 2016: Genome Announcements
V Gebhardt, L Mueller-Hansen, A Schwarz, D Bussen, C Weiss, M D Schmittner
BACKGROUND: Low-dose spinal anaesthesia is a safe and reliable anaesthesia technique in outpatient perianal surgery. Regarding its short duration of action and its trend to hyperbaric characteristics, plain chloroprocaine 10 mg/ml seems to be ideal to perform low-dose spinal anaesthesia. The aim of this trial was to determine the optimal dosage of chloroprocaine for this indication. METHODS: Hundred and twenty patients undergoing perianal surgery were enrolled and randomly allocated to receive 10, 20 or 30 mg of chloroprocaine 10 mg/ml intrathecally...
November 28, 2016: Acta Anaesthesiologica Scandinavica
Yat Yee Wong, Eva G Rakasz, David J Gasper, Thomas C Friedrich, Lauren A Trepanier
BACKGROUND: Sulfonamide hypersensitivity has a high incidence in HIV infection and correlates with low CD4+ counts, but the mechanisms are not understood. The aims of this study were to determine whether trimethoprim/sulfamethoxazole (TMP/SMX) led to SMX adduct formation, immunogenicity, or signs of drug hypersensitivity in SIV-infected rhesus macaques, and whether differences in antioxidants, pro-inflammatory mediators, or SMX disposition were predictive of drug immunogenicity. METHODS: Nine macaques chronically infected with SIVmac239 and 7 non-infected controls were studied...
August 10, 2016: Toxicology
J-M Halimi, L Vernier, P Gatault, C Barbet, J Roumy, J Marliere, H Longuet, E Merieau, B Sautenet, C Baron, M Buchler
OBJECTIVE: Some studies suggest that pulse pressure (PP) and renal resistive index (RI) could be predictive of the risk of death; however, whether they also predict graft loss is debated. It was recently demonstrated that RI reflects large artery arterial stiffness as PP does but RI is also affected by alteration in renal microcirculation alteration. Finally, the respective predictive value of these 2 parameters considered together on graft loss and death is unknown. DESIGN AND METHOD: Cohort study of consecutive patients who received a renal graft in Tours from 1985 to 2014 in whom PP and RI were measured at 3 months...
September 2016: Journal of Hypertension
Badurudeen Mahmood Buhary, Ohoud Almohareb, Naji Aljohani, Saad H Alzahrani, Samer Elkaissi, Suphia Sherbeeni, Abdulrahman Almaghamsi, Mussa Almalki
CONTEXT: Diabetes in pregnancy (DIP) is either pregestational or gestational. AIMS: To determine the relationship between glycemic control and pregnancy outcomes in a cohort of DIP patients. SETTINGS AND DESIGN: In this 12-month retrospective study, a total of 325 Saudi women with DIP who attended the outpatient clinics at a tertiary center Riyadh, Saudi Arabia, were included. SUBJECTS AND METHODS: The patients were divided into two groups, those with glycated hemoglobin (HbA1c) ≤6...
July 2016: Indian Journal of Endocrinology and Metabolism
Norikazu Kawai, Shuko Suzuki, Hiroshi Naito, Keiji Kushibe, Takashi Tojo, Yoshito Ikada, Shigeki Taniguchi
BACKGROUND: Air leak is a common problem in pulmonary surgical procedures. In this study, we evaluated the efficacy and safety of gelatin glue (cross-linked with glutaraldehyde) in a rat model of lung air leak. METHODS: A model of pulmonary fistula was created in the rat lung with the use of a needle. The fistula was then sealed with either gelatin glue (group A), fibrin glue (group B), or fibrin glue with a polyglycolic acid sheet (group C). The seal breaking pressures were measured for each group, and the results were compared...
July 2016: Annals of Thoracic Surgery
C C Kirwan, N J Bundred, J Castle, R Clarke, C Dive, J Morris, C Holcombe, J R Harvey
INTRODUCTION: Breast cancer is associated with a 3-4 fold increased risk of VTE. These patients have a 4-fold lower survival than those remaining free of VTE, implying VTE is a surrogate marker for aggressive cancer. Tumour expression of thrombin pathway markers are increased in the oestrogen receptor negative (ER-), high Ki67, more aggressive breast cancer subtypes. In in vitro and in vivo studies, the thrombin pathway promotes cancer growth and metastases, highlighting the potential role of the thrombin pathway as a therapeutic target in cancer...
April 2016: Thrombosis Research
Emily A Lalone, Ruby Grewal, Joy C MacDermid
The patient was a 15-year-old adolescent girl with a chief complaint of intermittent pain and clicking at her right distal radioulnar joint, after having fractured her forearm 5 months previously. Radiographs of the patient's forearm indicated a midshaft radial deformity. Given the patient's pain and limited range of motion, computed tomography imaging was requested to assess whether the midshaft malunion resulted in distal radioulnar joint instability and to plan the corrective osteotomy. J Orthop Sports Phys Ther 2016;46(5):399...
May 2016: Journal of Orthopaedic and Sports Physical Therapy
Željko Martinović, Dražen Kovač, Cvita Martinović
BACKGROUND: Angiogenesis plays a pivotal role in malignant tumor progression. The count of blood microvessels of the tumor has been recognized as an indicator of malignant potential of the tumors and provides the ability to predict tumors recurrence. The role endoglin in the Dukes B rectal cancer is still unexplored. The aims of this study were to examine immunohistochemical expression of endoglin in resected rectal cancer and investigate the relationship of tumor recurrence and other clinicopathological variables to the endoglin-assessed microvessel density of the tumor tissue and distal resection margins...
April 22, 2016: World Journal of Surgical Oncology
J M Halimi, L Vernier, P Gatault, C Barbet, J Roumy, J Marliere, H Longuet, E Merieau, B Sautenet, C Baron, M Buchler
OBJECTIFS: Certaines études ont suggéré que la pression pulsée (PP) et l'index de résistance intra-rénale (IR) pouvaient être prédictifs du risque de décès, mais leur impact sur la survie du greffon est controversé. Il a été montré que l'IR était un reflet de la rigidité artérielle des gros vaisseaux comme la PP, mais aussi de l'état de la microcirculation rénale. Cependant, l'impact respectif de ces 2 paramètres sur les risques de décès et de perte de greffon n'est pas connu, et a été l'objet de cette étude...
December 2015: Annales de Cardiologie et D'angéiologie
Lei Wang, Peng Cao, Wei Li, Peijin Tong, Xiaofang Zhang, Yiping Du
Solid Phase Extraction Spectroscopy (SPES) developed in this paper is a technique to measure spectrum directly on the solid phase material where the analytes are concentrated in SPE process. Membrane enrichment and UV-Visible spectroscopy were utilized to fulfill SPES, and multivariate calibration method of partial least squares (PLS) was used to simultaneously detect the concentrations of trace cobalt (II) and zinc (II) in water samples. The proposed method is simple, sensitive and selective. The complexes of analyte ions were collected on the cellulose acetate membranes via membrane filtration after the complexation reaction with 1-2-pyridylazo 2-naphthol (PAN)...
April 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Adela S Oliva Chávez, James W Fairman, Roderick F Felsheim, Curtis M Nelson, Michael J Herron, LeeAnn Higgins, Nicole Y Burkhardt, Jonathan D Oliver, Todd W Markowski, Timothy J Kurtti, Thomas E Edwards, Ulrike G Munderloh
Anaplasma phagocytophilum, the causative agent of Human Granulocytic Anaplasmosis (HGA), is an obligately intracellular α-proteobacterium that is transmitted by Ixodes spp ticks. However, the pathogen is not transovarially transmitted between tick generations and therefore needs to survive in both a mammalian host and the arthropod vector to complete its life cycle. To adapt to different environments, pathogens rely on differential gene expression as well as the modification of proteins and other molecules...
2015: PLoS Pathogens
Ruonan Duan, Hongmei Xue, Yan Liu, Mingzhe Yang, Guo Cheng
OBJECTIVE: To investigate eating behaviors of children and adolescents in Chengdu city, and to explore the associations between eating behaviors and overweight/ obesity among children. METHODS: A total of 2179 children and adolescents aged 7-15 years were recruited from Chengdu city by cluster random sampling method. A self-designed food frequency questionnaire was used to collect information on eating behaviors among children. Anthropometric data were measured to calculate percent body fat (PBF) and BMI Z-score...
July 2015: Wei Sheng Yan Jiu, Journal of Hygiene Research
Liyun Xu, Yanyan Huang, Linlin Tan, Wei Yu, Dongdong Chen, ChangChang Lu, Jianying He, Guoqing Wu, Xiaoguang Liu, Yongkui Zhang
T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) has been shown to play an important role in mediating NK-cell function in human diseases. However, the relationship between Tim-3 expression in natural killer (NK) cells and human lung adenocarcinoma remains unclear. We therefore investigated the expression of Tim-3 in NK cells and explored the effect of Tim-3 blockade on NK cell-mediated activity in human lung adenocarcinoma. Upregulated expression of Tim-3 on CD3-CD56+ cells (P<0.05) and CD3-CD56(dim) cells (P<0...
December 2015: International Immunopharmacology
M Kepper, T-S Tseng, J Volaufova, R Scribner, H Nuss, M Sothern
The study determined the association between body mass index (BMI) z score and fruit and vegetable intake, frequency and ratio of fast food outlets and grocery stores in concentric areas around the child's residence, outdoor play and total crime index. Data from 78 Louisiana pre-school children were analyzed using Pearson's correlation and multiple regression analysis. Parental-reported fruit intake was linearly associated with increased number of grocery store counts in concentric areas around the child's residence (P = 0...
October 2016: Pediatric Obesity
Yu Zhang, Hongji Yang, Xiaofan Deng, Yunfei Chen, Shikai Zhu, Chen Kai
BACKGROUND: Despite accumulated experience and advancing techniques for laparoscopic hepatectomy, bleeding remains the major concern during parenchymal transection. The vascular inflow control technique is still important to decrease intraoperative blood loss. The objective of this study was to compare intermittent Pringle with continuous hemihepatic vascular inflow occlusion using extra-glissonian approach in laparoscopic liver resection. METHODS: Between January 2011 and January 2015, a total of 79 consecutive patients with tumors locating either in the right or in the left hemiliver were included into this retrospective study (45 in the Pringle group vs...
March 2016: Surgical Endoscopy
Zeljko Martinovic, Drazen Kovac, Mia Martinovic
Background. The role of endoglin in the Dukes B rectal cancer is still unexplored. The aim of this study was to examine the expression of endoglin (CD105) in resected rectal cancer and to evaluate the relationship between microvessels density (MVD), clinicopathological factors, and survival rates. Methods. The study included 95 primary rectal adenocarcinomas, corresponding to 67 adjacent and 73 distant normal mucosa specimens from surgical resection samples. Tumor specimens were paraffin-embedded and immunohistochemical staining for the CD105 endothelial antigen was performed to count CD105-MVD...
2015: Gastroenterology Research and Practice
Adriana J Soares, Gustavo A Souza, Andrea C Pereira, Julio Vargas-Neto, Alexandre A Zaia, Emmanuel J N L Silva
This retrospective study evaluated the frequency of development of root resorption in dental trauma cases involving supporting tissue. For 249 traumatized teeth of 125 patients aged between 7 and 51 years, we collected data on the gender and age of the patient, the teeth involved, the type of trauma, and the period between dental injury and initial examination. Radiographic parameters examined in relation to root resorption included the presence of inflammatory external root resorption, internal root resorption, replacement resorption, and canal calcification...
June 2015: Journal of Oral Science
Johan P Woelber, Helena Bienas, Goetz Fabry, Waltraud Silbernagel, Marianne Giesler, Christian Tennert, Susanne Stampf, Petra Ratka-Krüger, Elmar Hellwig
AIM: The aim of this study was to assess whether oral hygiene-related self-efficacy is correlated with current oral hygiene and might influence the outcome of oral hygiene instruction. MATERIALS AND METHODS: Hundred and twenty-six patients filled out questionnaires about oral hygiene-related self-efficacy, general self-efficacy, oral hygiene-related knowledge and demographic variables. Plaque and gingival inflammation were measured and an individual oral hygiene plan was conducted...
February 2015: Journal of Clinical Periodontology
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