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https://www.readbyqxmd.com/read/27919243/tumour-stage-distribution-and-survival-of-malignant-melanoma-in-germany-2002-2011
#1
Olaf Schoffer, Stefanie Schülein, Gerlinde Arand, Hans Arnholdt, Dieter Baaske, Ralf C Bargou, Nikolaus Becker, Matthias W Beckmann, Yves Bodack, Beatrix Böhme, Tayfun Bozkurt, Regine Breitsprecher, Andre Buchali, Elke Burger, Ulrike Burger, Klaus Dommisch, Gudrun Elsner, Karin Fernschild, Ulrike Flintzer, Uwe Funke, Michael Gerken, Hubert Göbel, Norbert Grobe, Vera Gumpp, Lucie Heinzerling, Lana Raffaela Kempfer, Alexander Kiani, Monika Klinkhammer-Schalke, Sabine Klöcking, Ute Kreibich, Katrin Knabner, Peter Kuhn, Stine Lutze, Uwe Mäder, Tanja Maisel, Jan Maschke, Martin Middeke, Andreas Neubauer, Antje Niedostatek, Anabelle Opazo-Saez, Christoph Peters, Beatrice Schell, Gerhard Schenkirsch, Harald Schmalenberg, Peter Schmidt, Constanze Schneider, Birgit Schubotz, Anika Seide, Paul Strecker, Sabine Taubenheim, Matthias Wackes, Steffen Weiß, Claudia Welke, Carmen Werner, Christian Wittekind, Jörg Wulff, Heike Zettl, Stefanie J Klug
BACKGROUND: Over the past two decades, there has been a rising trend in malignant melanoma incidence worldwide. In 2008, Germany introduced a nationwide skin cancer screening program starting at age 35. The aims of this study were to analyse the distribution of malignant melanoma tumour stages over time, as well as demographic and regional differences in stage distribution and survival of melanoma patients. METHODS: Pooled data from 61 895 malignant melanoma patients diagnosed between 2002 and 2011 and documented in 28 German population-based and hospital-based clinical cancer registries were analysed using descriptive methods, joinpoint regression, logistic regression and relative survival...
December 5, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27917981/the-role-of-pastoralism-in-regulating-ecosystem-services
#2
M A Seid, N J Kuhn, T Z Fikre
Pastoralism is rarely viewed as a major future form of land use, because of well-documented cases of rangeland degradation, attributed to irrational overstocking by pastoralists, and the subsequent losses of ecosystem services. However, pastoralists were actually encouraged to settle and adopt such strategies, copied from rangelands with higher and more reliable rainfall. This curtailed mobility resulted in a shift from opportunistic and extensive land use to more intensive and settled forms of use. The purpose of this review is to examine the link between pastoralism and the provision of ecosystem services by rangelands, focusing on biodiversity conservation and carbon sequestration...
November 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/27917964/communication-for-the-development-of-pastoralism
#3
M A Seid, L W Yoseph, U W Befekadu, A Muhammed, T Z Fikre
Communication is vital for the socio-economic and cultural development of pastoralists. If used constructively, communication can help to create a favourable environment for change and modernisation. This paper tries to uncover trends in communication as part of pastoral development, emphasising both indigenous and current methods of communication and prevailing constraints. This study reveals that pastoral development interventions in the past have often failed to achieve their goals, due to the centralised, 'top-down' approaches adopted and to reliance on external strategies and channels which ignored the indigenous knowledge and communications systems of pastoralists...
November 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/27917960/a-vision-for-the-future-of-pastoralism
#4
J Zinsstag, B Bonfoh, G Zinsstag, L Crump, I O Alfaroukh, M F Abakar, J Kasymbekov, Z Baljinnyam, K Liechti, M A Seid, E Schelling
Pastoral regions are challenged by social and ecological changes. Yet, there is increasingly robust evidence that pastoralism is a viable and sustainable livelihood and that pastoralists play a role in attaining the United Nations Sustainable Development Goals (SDGs). In this issue of the Scientific and Technical Review of the World Organisation for Animal Health (OIE), the authors take a broad view of pastoralism and pastoral livestock production from a number of different perspectives, taking into account societal and ecological viewpoints as well as issues of animal and human health...
November 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/27902860/genetic-and-biochemical-interactions-between-the-bacterial-replication-initiator-dnaa-and-the-nucleoid-associated-protein-rok-in-bacillus-subtilis
#5
Charlotte A Seid, Janet L Smith, Alan D Grossman
We identified interactions between the conserved bacterial replication initiator and transcription factor DnaA and the nucleoid-associated protein Rok of Bacillus subtilis. DnaA binds directly to clusters of DnaA boxes at the origin of replication and elsewhere, including the promoters of several DnaA-regulated genes. Rok, an analog of H-NS from gamma-proteobacteria that affects chromosome architecture and Lsr2 from Mycobacteria, binds A+T-rich sequences throughout the genome and represses expression of many genes...
November 30, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27773761/expression-purification-immunogenicity-and-protective-efficacy-of-a-recombinant-nucleoside-hydrolase-from-leishmania-donovani-a-vaccine-candidate-for-preventing-cutaneous-leishmaniasis
#6
C Patrick McAtee, Christopher A Seid, Molly Hammond, Elissa Hudspeth, Brian P Keegan, Zhuyun Liu, Junfei Wei, Bin Zhan, Raul Arjona-Sabido, Vladimir Cruz-Chan, Eric Dumonteil, Peter J Hotez, Maria Elena Bottazzi
The nucleoside hydrolase gene from Leishmania donovani was cloned and expressed in Escherichia coli as a full length 36-kDa protein (LdNH36). Following lysis and extraction, the protein was purified by anion exchange and gel filtration chromatography. The purified protein had a molecular mass of approximately 36-kDa and was confirmed to be >99% pure. Using a nucleoside hydrolase assay, the protein was found to exhibit a Km of 741 ± 246 μM. Protein integrity was confirmed by lithium dodecyl sulfate polyacrylamide gel electrophoresis (LDS-PAGE), mass spectrometry (MS), and enzymatic assay...
October 20, 2016: Protein Expression and Purification
https://www.readbyqxmd.com/read/27764192/incidence-of-exposure-of-patients-in-the-united-states-to-multiple-drugs-for-which-pharmacogenomic-guidelines-are-available
#7
Matthias Samwald, Hong Xu, Kathrin Blagec, Philip E Empey, Daniel C Malone, Seid Mussa Ahmed, Patrick Ryan, Sebastian Hofer, Richard D Boyce
Pre-emptive pharmacogenomic (PGx) testing of a panel of genes may be easier to implement and more cost-effective than reactive pharmacogenomic testing if a sufficient number of medications are covered by a single test and future medication exposure can be anticipated. We analysed the incidence of exposure of individual patients in the United States to multiple drugs for which pharmacogenomic guidelines are available (PGx drugs) within a selected four-year period (2009-2012) in order to identify and quantify the incidence of pharmacotherapy in a nation-wide patient population that could be impacted by pre-emptive PGx testing based on currently available clinical guidelines...
2016: PloS One
https://www.readbyqxmd.com/read/27759778/long-term-results-after-stapled-hemorrhoidopexy-alone-and-complemented-by-excisional-hemorrhoidectomy-a-retrospective-cohort-study
#8
Sergio Eduardo Alonso Araujo, Lucas de Araujo Horcel, Victor Edmond Seid, Alexandre Bruno Bertoncini, Sidney Klajner
Background: Stapled hemorrhoidopexy is associated with less postoperative pain and faster recovery. However, it may be associated with a greater risk of symptomatic recurrence. We hypothesized that undertaking a limited surgical excision of hemorrhoid disease after stapling may be a valid approach for selected patients. Aim: To compare long-term results after stapled hemorrhoidopexy with and without complementation with closed excisional technique. Method: In a retrospective uni-institutional cohort study, sixty-five (29 men) patients underwent stapled hemorrhoidopexy and 21 (13 men) underwent stapled hemorrhoidopexy with excision...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27747591/an-adaptive-annotation-approach-for-biomedical-entity-and-relation-recognition
#9
Seid Muhie Yimam, Chris Biemann, Ljiljana Majnaric, Šefket Šabanović, Andreas Holzinger
In this article, we demonstrate the impact of interactive machine learning: we develop biomedical entity recognition dataset using a human-into-the-loop approach. In contrary to classical machine learning, human-in-the-loop approaches do not operate on predefined training or test sets, but assume that human input regarding system improvement is supplied iteratively. Here, during annotation, a machine learning model is built on previous annotations and used to propose labels for subsequent annotation. To demonstrate that such interactive and iterative annotation speeds up the development of quality dataset annotation, we conduct three experiments...
September 2016: Brain Informatics
https://www.readbyqxmd.com/read/27737611/cysteine-mutagenesis-improves-the-production-without-abrogating-antigenicity-of-a-recombinant-protein-vaccine-candidate-for-human-chagas-disease
#10
Christopher A Seid, Kathryn M Jones, Jeroen Pollet, Brian Keegan, Elissa Hudspeth, Molly Hammond, Junfei Wei, C Patrick McAtee, Leroy Versteeg, Amanda Gutierrez, Zhuyun Liu, Bin Zhan, Jonathan L Respress, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez
A therapeutic vaccine for human Chagas disease is under development by the Sabin Vaccine Institute Product Development Partnership. The aim of the vaccine is to significantly reduce the parasite burden of Trypanosoma cruzi in humans, either as a standalone product or in combination with conventional chemotherapy. Vaccination of mice with Tc24 formulated with monophosphoryl-lipid A (MPLA) adjuvant results in a Th1 skewed immune response with elevated IgG2a and IFNγ levels and a statistically significant decrease in parasitemia following T...
October 13, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27736152/high-health-satisfaction-among-emerging-adults-with-diabetes-factors-predicting-resilience
#11
Sarah D Corathers, Jessica C Kichler, Nora F Fino, Wei Lang, Jean M Lawrence, Jennifer K Raymond, Joyce P Yi-Frazier, Dana Dabelea, Angela D Liese, Sharon H Saydah, Michael Seid, Lawrence M Dolan
Objective: This study was conducted to identify factors contributing to health satisfaction outcomes among emerging adults (ages 18-25) with diabetes. Method: SEARCH for Diabetes in Youth study participants whose diabetes was prevalent in 2001 and were ≥18 years of age when they completed a 2008-2009 follow-up survey (n = 340) were included. We developed a health resilience model (HRM) to identify potentially modifiable factors (anticipatory guidance, social support, physical activity, quality of life) associated with health outcomes (satisfaction with health care, overall personal health, self-report of hemoglobin A1c [HbA1c])...
October 13, 2016: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/27696568/postural-orthostatic-tachycardia-is-not-a-useful-diagnostic-marker-for-chronic-fatigue-syndrome
#12
M E Roerink, J W M Lenders, I C Schmits, A M A Pistorius, J W Smit, H Knoop, J W M van der Meer
BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is considered a diagnostic marker for chronic fatigue syndrome (CFS). OBJECTIVES: The aims of this study were to (i) compare POTS prevalence in a CFS cohort with fatigued patients not meeting CFS criteria, and (ii) assess activity, impairment and response to cognitive behavioural therapy (CBT) in CFS patients with POTS (POTS-CFS) and without POTS (non-POTS-CFS). METHODS: Prospective cohort study at the Radboud University Medical Centre in the Netherlands...
October 2, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27608678/ethiopian-teachers-their-knowledge-attitude-and-practice-towards-epilepsy
#13
Meron Awraris Gebrewold, Fikre Enquselassie, Redda Teklehaimanot, Seid Ali Gugssa
BACKGROUND: In Ethiopia where the burden of epilepsy is highest among school age children and teenagers, and where people with epilepsy (PWE) and their relatives suffers from high level of perceived stigma, there had not been any study that assessed the knowledge, attitude and practice of teachers towards PWE. This study aims to assess and understand the social and demographic determinants of knowledge, attitude and practice of teachers towards PLW in Addis Ababa, Ethiopia. METHODS: Multistage cluster sampling procedure was used to identify twenty schools from three sub cities of Addis Ababa, Ethiopia...
September 8, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27596403/nano-encapsulation-of-fish-oil-in-nano-liposomes-and-its-application-in-fortification-of-yogurt
#14
Tahere Ghorbanzade, Seid Mahdi Jafari, Sahar Akhavan, Roxana Hadavi
Fish oils have many dietary benefits, but due to their strong odors and rapid deterioration, their application in food formulations is limited. For these reasons, nano-liposome was used to nano-encapsulate fish oil in this study and encapsulated fish oil was utilized in fortifying yogurt. Physicochemical properties of produced yogurt including pH, acidity, syneresis, fatty acid composition, peroxide value as well as sensory tests were investigated during three weeks storage at 4°C. Nano-liposome encapsulation resulted in a significant reduction in acidity, syneresis and peroxide value...
February 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27516916/valproic-acid-induced-hyperammonemia-in-a-long-time-treated-patient
#15
Rohit Aiyer, Margaret Seide, Robert G Stern
We report a case of a patient who had been on long time valproic acid for treatment of bipolar affective disorder. While being an inpatient, serology ammonia level testing revealed a very high ammonia level despite being asymptomatic. Dual therapy of carnitine and lactulose was provided to the patient for treatment of the hyperammonemia. It should also be noted that, during this treatment, valproic acid was not stopped. Consequently, this case illustrates that patients can present asymptomatically despite very high ammonia levels and hyperammonemia can occur in chronic valproic acid despite not increasing the dose of the medication and psychiatrists do not need to discontinue valproic acid in the presence of elevated levels of ammonia if the patient shows no signs of encephalopathy or delirium...
2016: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/27507989/comparative-efficacy-of-topical-curcumin-and-triamcinolone-for-oral-lichen-planus-a-randomized-controlled-clinical-trial
#16
Seid Javad Kia, Shiva Shirazian, Arash Mansourian, Leila Khodadadi Fard, Sajjad Ashnagar
OBJECTIVES: Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. Its treatment is often symptomatic and includes topical and systemic corticosteroids. Although corticosteroid therapy is usually successful, it has side effects and thus, an alternative treatment is favorable. The aim of this study was to compare the efficacy of topical curcumin and triamcinolone for treatment of oral lichen planus (OLP). MATERIALS AND METHODS: In this study, 50 patients (36 women and 14 men) in the age range of 38 to 73 years with OLP were randomly divided into two groups...
November 2015: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27488366/allogeneic-anorectal-transplantation-in-rats-technical-considerations-and-preliminary-results
#17
Flavio H F Galvão, Daniel R Waisberg, Victor E Seid, Anderson C L Costa, Eleazar Chaib, Rachel Rossini Baptista, Vera Luiza Capelozzi, Cinthia Lanchotte, Ruy J Cruz, Jun Araki, Luiz Carneiro D'Albuquerque
Fecal incontinence is a challenging condition with numerous available treatment modalities. Success rates vary across these modalities, and permanent colostomy is often indicated when they fail. For these cases, a novel potential therapeutic strategy is anorectal transplantation (ATx). We performed four isogeneic (Lewis-to-Lewis) and seven allogeneic (Wistar-to-Lewis) ATx procedures. The anorectum was retrieved with a vascular pedicle containing the aorta in continuity with the inferior mesenteric artery and portal vein in continuity with the inferior mesenteric vein...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27454156/reliability-and-validity-of-the-psoriasis-itch-visual-analog-scale-in-psoriasis-vulgaris
#18
Claus Bang Pedersen, Colleen A McHorney, Lotte Seiding Larsen, Katja Wendicke Lophaven, Anders Holmen Moeller, Matthew Reaney
INTRODUCTION: The single-item Psoriasis Itch VAS was developed to measure itch intensity within the last 24 hours in psoriasis vulgaris to assess treatment benefit. Its psychometric properties were explored in two trials. METHODS: Data from two randomized, parallel-group phase 3 trials with subjects suffering from psoriasis vulgaris on the body (n = 426, 463) were analyzed. Cross-sectional distributional properties and construct validity of the Psoriasis Itch VAS as well as longitudinal test-retest reliability and sensitivity to change of the Psoriasis Itch VAS were investigated...
July 25, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27452330/igfbp-1-marker-of-cervical-ripening-and-predictor-of-preterm-birth
#19
Larisa Mešić Ðogić, Dragana Mićić, Feđa Omeragić, Refka Kovač, Seid Fazlagić
Aim To establish a correlation between positive values of IGFBP-1(>10 mg/L, Actim Partus Test, APT) and premature cervical ripening in imminent preterm labor. Methods A prospective study was conducted in primary health care centers in Tuzla, Gynecology and Obstetrics Clinic of the University Clinical Centre in Tuzla and General Hospital Tešanj. The study included 50 women (singleton pregnancy, 28-37 week) with imminent preterm labor diagnosed by cervical biometry and modified Bishop score) (examinees) and 30 healthy pregnant women (control group)...
August 1, 2016: Medicinski Glasnik
https://www.readbyqxmd.com/read/27419648/biopolymer-nano-particles-and-natural-nano-carriers-for-nano-encapsulation-of-phenolic-compounds
#20
REVIEW
Afshin Faridi Esfanjani, Seid Mahdi Jafari
Phenolic compounds are major micronutrients in our diet,(1) and evidence for their role in the prevention of degenerative diseases such as cancer, inflammation and neurodegenerative diseases is emerging. The easily destruction against environment stresses and low bioavailability of phenolics are main limitations of their application. Therefore, nano-encapsulated phenolics as a fine delivery system can solve their restrictions. Polymeric nanoparticles and natural nano-carriers are one of the most effective and industrial techniques which can be used for protection and delivery of phenolics...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
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