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https://www.readbyqxmd.com/read/28215042/platelet-mediated-modulation-of-fibrinolysis
#1
Claire S Whyte, Joanne L Mitchell, Nicola J Mutch
Platelets are crucial to the hemostatic response. Their role in coagulation is well documented and they have been considered for some time to promote resistance of thrombi to fibrinolysis. Platelets confer resistance to lysis by promoting clot retraction of the immediate fibrin network and through release of plasminogen activator inhibitor-1 from their α-granules. However, recent developments in the field indicate that the role of platelets in fibrinolysis is much more diverse. Indeed, novel studies suggest that platelets form different subpopulations upon activation that play varied roles in regulating hemostasis...
February 19, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28214640/the-art-of-mimicry-anterior-clinoid-dural-based-cavernous-hemangioma-mistaken-for-a-meningioma
#2
Tarek R Mansour, Yacine Medhkour, Pouya Entezami, Robert Mrak, Jason Schroeder, Azedine Medhkour
BACKGROUND: Cavernous hemangiomas account for 5-13% of central nervous system vascular lesions. They are usually found intra-axially but rarely involve extra-axial structures, most commonly the middle cranial fossa. A cavernous hemangioma presenting as a clinoid meningioma is extremely rare. CASE DESCRIPTION: We present a 36-year-old male with an asymptomatic intracranial mass found incidentally after an ATV accident. Preoperative MRI revealed a well-defined dural-based lesion arising from the right anterior clinoid process which was nearly homogenously enhancing, with a radiological diagnosis of meningioma...
February 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28212919/thrombus-composition-in-sudden-cardiac-death-from-acute-myocardial-infarction
#3
Johanne Silvain, Jean-Philippe Collet, Paul Guedeney, Olivier Varenne, Chandrasekaran Nagaswami, Carole Maupain, Jean-Philippe Empana, Chantal Boulanger, Muriel Tafflet, Stephane Manzo-Silberman, Mathieu Kerneis, Delphine Brugier, Nicolas Vignolles, John W Weisel, Xavier Jouven, Gilles Montalescot, Christian Spaulding
BACKGROUND AND AIM: It was hypothesized that the pattern of coronary occlusion (thrombus composition) might contribute to the onset of ventricular arrhythmia and sudden cardiac death (SCD) in myocardial infarction (MI). METHODS: The TIDE (thrombus and inflammation in sudden death) study included patients with angiographically-proven acute coronary occlusion as the cause of a ST elevation MI (STEMI) complicated by Sudden Cardiac Death (SCD group) or not (STEMI group)...
February 14, 2017: Resuscitation
https://www.readbyqxmd.com/read/28209798/neutrophil-extracellular-traps-in-atherosclerosis-and-atherothrombosis
#4
REVIEW
Yvonne Döring, Oliver Soehnlein, Christian Weber
Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These net-like structures have also been detected in atherosclerotic lesions and arterial thrombi in humans and mice. Functionally, neutrophil extracellular traps have been shown to induce activation of endothelial cells, antigen-presenting cells, and platelets, resulting in a proinflammatory immune response. Overall, this suggests that they are not only present in plaques and thrombi but also they may play a causative role in triggering atherosclerotic plaque formation and arterial thrombosis...
February 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28207887/platelet-monocyte-derived-and-tissue-factor-carrying-circulating-microparticles-are-related-to-acute-myocardial-infarction-severity
#5
Gemma Chiva-Blanch, Kristian Laake, Peder Myhre, Vibeke Bratseth, Harald Arnesen, Svein Solheim, Lina Badimon, Ingebjørg Seljeflot
OBJECTIVE: Circulating microparticles (cMPs) are phospholipid-rich vesicles released from cells when activated or injured, and contribute to the formation of intracoronary thrombi. Tissue factor (TF, CD142) is the main trigger of fibrin formation and TF-carrying cMPs are considered one of the most procoagulant cMPs. Similar types of atherosclerotic lesions may lead to different types of AMI, although the mechanisms behind are unresolved. Therefore, we aimed to investigate the phenotype of cMPs found in plasma of ACS patients and its relation to AMI severity and thrombotic burden...
2017: PloS One
https://www.readbyqxmd.com/read/28198520/twelve-month-follow-up-of-left-atrial-appendage-occlusion-with-amplatzer-amulet
#6
Caroline Kleinecke, Jai-Wun Park, Martin Gödde, Konstantin Zintl, Steffen Schnupp, Johannes Brachmann
BACKGROUND: The Amplatzer Amulet (St. Jude Medical, Minneapolis, MN, USA) is a second generation Amplatzer device for left atrial appendage occlusion for stroke prophylaxis in patients with atrial fibrillation. This research sought to assess the clinical performance of the Amplatzer Amulet device and in follow up for 12 months. METHODS: In this single-center registry patients with atrial fibrillation and contraindication to oral anticoagulation underwent left atrial appendage occlusion (LAAO) with the Amplatzer Amulet device...
February 15, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28195879/fibrin-associated-ebv-positive-large-b-cell-lymphoma-an-indolent-neoplasm-with-features-distinct-from-diffuse-large-b-cell-lymphoma-associated-with-chronic-inflammation
#7
Daniel F Boyer, Penelope A McKelvie, Laurence de Leval, Kerstin L Edlefsen, Young-Hyeh Ko, Zachary A Aberman, Alexandra E Kovach, Aneal Masih, Ha T Nishino, Lawrence M Weiss, Alan K Meeker, Valentina Nardi, Maryknoll Palisoc, Lina Shao, Stefania Pittaluga, Judith A Ferry, Nancy Lee Harris, Aliyah R Sohani
Incidental cases of localized fibrin-associated Epstein-Barr virus (EBV)+ large B-cell proliferations have been described at unusual anatomic sites and have been included in the category of diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI) in the WHO Classification. We describe 12 cases and review the literature to define their clinicopathologic spectrum and compare features with typical cases of DLBCL-CI. Median age was 55.5 years with a M:F ratio of 3. In all 12 cases, the lymphoma was an incidental microscopic finding involving atrial myxomas (n=3), thrombi associated with endovascular grafts (n=3), chronic hematomas (n=2), and pseudocysts (n=4)...
March 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28195071/spatial-differences-of-matrix-metalloproteinase-2-and-matrix-metalloproteinase-9-within-abdominal-aortic-aneurysm-wall-and-intraluminal-thrombus
#8
A Siennicka, M Zuchowski, M Kaczmarczyk, M Cnotliwy, J S Clark, M Jastrzebska
Formation of an abdominal aortic aneurysm is a complex process involving aortic wall degradation. The matrix metalloproteinases (MMPs) mainly involved in this process are MMP-2 and MMP-9. Most aneurysms contain an intraluminal thrombus. It is suggested that the thrombus' thickness correlates with the risk of aneurysm rupture and may be a new prognostic factor. The purpose of the present study was to investigate enzyme protein levels in thick (A1) and thin (B1) segments of the thrombus and aneurysm wall sections A (adjacent to A1) and B (adjacent to B1)...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28194181/simultaneous-left-ventricular-and-deep-vein-thrombi-caused-by-protein-c-deficiency
#9
Harufumi Maki, Motohiro Nishiyama, Motoaki Shirakawa
Protein C deficiency is a risk of venous thrombosis because of poor fibrinolytic activity. It remains controversial whether protein C deficiency causes arterial thrombosis. A 21-year-old woman was referred with a chief complaint of right leg pain and numbness. Contrast-enhanced computed tomography revealed a low-density mass in the left ventricle (LV), splenic infarction, and peripheral arterial obstructions in her right leg. Thrombosis extending from the renal vein to the inferior vena cava was also detected...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28192448/differential-inhibitory-action-of-apixaban-on-platelet-and-fibrin-components-of-forming-thrombi-studies-with-circulating-blood-and-in-a-platelet-based-model-of-thrombin-generation
#10
Lluis Pujadas-Mestres, Irene Lopez-Vilchez, Eduardo Arellano-Rodrigo, Joan Carles Reverter, Antonio Lopez-Farre, Maribel Diaz-Ricart, Juan Jose Badimon, Gines Escolar
INTRODUCTION: Mechanisms of action of direct oral anticoagulants (DOAC) suggest a potential therapeutic use in the prevention of thrombotic complications in arterial territories. However, effects of DOACs on platelet activation and aggregation have not been explored in detail. We have investigated the effects of apixaban on platelet and fibrin components of thrombus formation under static and flow conditions. METHODS: We assessed the effects of apixaban (10, 40 and 160 ng/mL) on: 1) platelet deposition and fibrin formation onto a thrombogenic surface, with blood circulating at arterial shear-rates; 2) viscoelastic properties of forming clots, and 3) thrombin generation in a cell-model of coagulation primed by platelets...
2017: PloS One
https://www.readbyqxmd.com/read/28191906/intracardiac-echocardiography-for-verification-for-left-atrial-appendage-thrombus-presence-detected-by-transesophageal-echocardiography-the-actionice-ii-study
#11
Jakub Baran, Beata Zaborska, Roman Piotrowski, Malgorzata Sikora-Frąc, Ewa Pilichowska-Paszkiet, Piotr Kułakowski
BACKGROUND: Transesophageal echocardiography (TEE) remains the gold standard for exclusion of left atrial appendage (LAA) thrombus in patients scheduled for direct electrical cardioversion (DEC) or atrial fibrillation (AF) ablation. Recently, intracardiac echocardiography (ICE) of the pulmonary artery (PA) has been shown to provide excellent LAA images and to be useful in verification of equivocal TEE findings. HYPOTHESIS: ICE of the PA may have a role in detecting false-positive TEE results...
February 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28190820/pulmonary-neuroendocrine-tumor-in-a-female-wolf-canis-lupus-lupus
#12
Ayako Shiraki, Toshinori Yoshida, Masahi Kawashima, Hirotada Murayama, Rei Nagahara, Nanao Ito, Makoto Shibutani
A 17-year-old female wolf (Canis lupus lupus) had a right lung mass that was adhered to the thoracic cavity. Histopathological examination revealed that the mass consisted of sheets, cord or ribbon-like structures of monotonous, small, cuboidal cells with round, oval or short-spindle nuclei and scant clear cytoplasm, demarcated by a fine fibrovascular stroma. Focal necrosis, congestion and thrombi were observed. Immunohistochemically, the tumor cells diffusely expressed cytokeratin AE1/AE3, and some expressed chromogranin A, neural cell adhesion molecule (CD56) and thyroid transcription factor-1...
February 11, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28181272/left-atrial-appendage-closure-for-stroke-prevention-more-choice-is-always-a-good-thing
#13
EDITORIAL
Rong Bai
While oral anticoagulants (OACs) remains the main strategy of prevention of thromboembolic event in patients with atrial fibrillation (AF), left atrial appendage closure (LAAC) has become an alternative recently. The concept of this technique is based on the understanding that in more than 90% non-valvular AF patients, the thrombi form in the left atrial appendage (LAA), so excluding the LAA from the systemic circulation can prevent stroke or peripheral arterial embolization. To achieve this goal, novel trans-catheter techniques have been developed to either occlude the LAA endocardially or ligate the LAA epicardially...
February 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28180915/-nonthrombotic-pulmonary-embolisms
#14
A G Bach, D Schramm, A Surov
The term nonthrombotic pulmonary embolism (NTPE) is defined as embolization of pulmonary arteries caused by foreign bodies (e. g. detached catheter fragments), biological substances (e. g. septic thrombus) or exogenous substances (e. g. gas). The frequency of NTPE is underestimated. Symptoms can cover the spectrum from undetectable to sudden death. In addition to mechanical obstruction of the pulmonary arteries, some NTPEs trigger an inflammatory cascade that causes deterioration of vascular, pulmonary and cardiac function...
February 8, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28180197/added-value-of-two-dimensional-shear-wave-elastography-to-ultrasonography-for-staging-common-femoral-vein-thrombi
#15
Fu-Shun Pan, Wen-Shuo Tian, Jia Luo, Ming Liu, Jin-Yu Liang, Ming Xu, Yan-Ling Zheng, Xiao-Yan Xie
: prove the performance for staging common femoral vein thrombi (CFVT). MATERIAL AND METHODS: A total of 194 consecutive patients with CFVT who underwent US and 2D-SWE were enrolled. These patients were categorized into three groups according to CFVT duration: Stage A (≤14 days), Stage B (14 days to 6 months), and Stage C (≥6 months). The diagnostic performance was assessed by the area under the receiver operating characteristic curve (AUC). RESULTS: Among all US features, CFV diameter ratio of thrombosed leg to contralateral leg (CFVD_ratio) showed the highest AUC in predicting Stage A and Stage C (0...
January 31, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28179613/left-atrial-appendage-thrombi-formation-in-japanese-non-valvular-atrial-fibrillation-patients-during-anticoagulation-therapy%C3%A3-warfarin-vs-direct-oral-anticoagulants
#16
Mihoko Kawabata, Masahiko Goya, Takeshi Sasaki, Shingo Maeda, Yasuhiro Shirai, Takuro Nishimura, Takakatsu Yoshitake, Shinya Shiohira, Mitsuaki Isobe, Kenzo Hirao
BACKGROUND: Atrial fibrillation (AF) is a common cardiac arrhythmia, associated with increased cardiovascular morbidity and mortality including thromboembolic events. The aims of this study were to assess the prevalence of left atrial appendage (LAA) thrombi in Japanese non-valvular atrial fibrillation (NVAF) patients undergoing preprocedural transesophageal echocardiography (TEE) during anticoagulation therapy, and to compare the efficacy of warfarin and direct oral anticoagulants (DOAC)...
February 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28174341/pulmonary-artery-aneurysms-and-thrombi
#17
C M J Steendam, A L Diederik, A Dendooven, R J Snijder, G J Herder
No abstract text is available yet for this article.
February 7, 2017: Thorax
https://www.readbyqxmd.com/read/28170136/intracranial-posterior-circulation-large-artery-thrombi-visualized-using-susceptibility-weighted-mri
#18
Naidong Wang, Qimin Hu, Qiaoshu Wang, Jinglong Zhao, Nikita Dedhia, Louis R Caplan
PURPOSE: To identify thrombi in patients with posterior circulation large artery occlusion using susceptibility-weighted magnetic resonance imaging (MRI). METHODS: All patients hospitalized with intracranial posterior circulation occlusion from January 2003 to September 2013 were included. MRI and computed tomography angiography were reviewed to determine the presence of arterial occlusion and identify thrombi. Eighty-one patients were analyzed to investigate susceptibility vessel sign (SVS) that was identified as blooming artifact (BA) on T2*-weighted gradient echo imaging...
February 7, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28169486/hepatic-vena-cava-syndrome-new-concept-of-pathogenesis
#19
REVIEW
Santosh Man Shrestha, Masayoshi Kage, Byung Boong Lee
Hepatic vena cava syndrome (HVCS) also known as membranous obstruction of inferior vena cava was considered a rare congenital disease and included under Budd Chiari syndrome. It is now recognized as a bacterial infection induced disease related to poor hygienic living condition. Localized thrombophlebitis of IVC at the site close to hepatic veins (HV) outlets is the initial lesion which converts on resolution into stenosis or complete obstruction, the circulatory equilibrium being maintained by development of cavo-caval collateral anastomosis...
February 7, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28162796/-balloon-pulmonary-angioplasty-an-additional-treatment-option-to-improve-the-status-of-patients-with-chronic-thromboembolic-pulmonary-hypertension
#20
H Bouvaist
In chronic thromboembolic pulmonary hypertension (CTEPH), stenoses or obstructions of the pulmonary arteries due to organized thrombi can cause an elevation in pulmonary artery resistance, which in turn can result in pulmonary hypertension and progressive right heart failure. CTEPH can be cured surgically by pulmonary endarterectomy (PEA); however, patients deemed unsuitable for PEA due to distal lesion, advanced age, or comorbidities have a poor prognosis and limited treatment options. Recently, an alternative interventional strategy of balloon pulmonary angioplasty (BPA) reduces pulmonary artery hypertension in patients with CTEPH...
February 2, 2017: Revue de Pneumologie Clinique
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