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https://www.readbyqxmd.com/read/28323990/galactose-supplementation-in-tmem165-cdg-patients-rescues-the-glycosylation-defects
#1
Willy Morelle, Sven Potelle, Peter Witters, Sunnie Wong, Leslie Climer, Vladimir Lupashin, Gert Matthijs, Therese Gadomski, Jaak Jaeken, David Cassiman, Eva Morava, François Foulquier
Context: TMEM165 deficiency is a severe multisystem disease that manifests with metabolic, endocrine and skeletal involvement. It leads to one type of congenital disorders of glycosylation (CDG), a rapidly growing group of inherited diseases where the glycosylation process is altered. Patients have decreased galactosylation by serum glycan analysis. There are over one hundred CDGs but only specific types are treatable. Objective: Galactose has been shown to be beneficial in other CDG types with abnormal galactosylation...
January 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323989/preconception-low-dose-aspirin-restores-diminished-pregnancy-and-live-birth-rates-in-women-with-low-grade-inflammation-a-secondary-analysis-of-a-randomized-trial
#2
Lindsey A Sjaarda, Rose G Radin, Robert M Silver, Emily Mitchell, Sunni L Mumford, Brian Wilcox, Noya Galai, Neil J Perkins, Jean Wactawski-Wende, Joseph B Stanford, Enrique F Schisterman
Context: Inflammation is linked to causes of infertility. Low dose aspirin (LDA) may improve reproductive success in women with chronic, low-grade inflammation. Objective: To investigate the effect of preconception-initiated LDA on pregnancy rate, pregnancy loss, live birth rate, and inflammation during pregnancy. Design: Stratified secondary analysis of a multi-center, block-randomized, double-blind, placebo-controlled trial. Setting: Four U...
February 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323976/protective-effects-of-fetal-zone-steroids-are-comparable-to-estradiol-in-hyperoxia-induced-cell-death-of-immature-glia
#3
Stephanie Hübner, Donna E Sunny, Christine Pöhlke, Johanna Ruhnau, Antje Vogelgesang, Bettina Reich, Matthias Heckmann
Impaired neurodevelopment in preterm infants is caused by prematurity itself; however, hypoxia/ischemia, inflammation, and hyperoxia contribute to the extent of impairment. Because preterm birth is accompanied by a dramatic decrease in 17β-estradiol (E2) and progesterone, preliminary clinical studies have been carried out to substitute these steroids in preterm infants; however, they failed to confirm significantly improved neurological outcomes. We therefore hypothesized that the persistently high postnatal production of fetal zone steroids (mainly dehydroepiandrosterone (DHEA)) until term could interfere with E2-mediated protection...
March 3, 2017: Endocrinology
https://www.readbyqxmd.com/read/28319625/photoprotection-prevents-skin-cancer-let-s-make-it-fashionable-to-wear-sun-protective-clothing
#4
Jeffrey M Milch, Nicholas F Logemann
Protection from UV radiation (UVR) is of paramount importance in preventing skin cancers, the majority of which occur on sun-exposed areas of the face, ears, and neck. A reusable, inexpensive, and truly simple measure of personal protection that greatly reduces exposure to UVR, thereby reducing the risk for developing skin cancers, can be achieved simply by regularly wearing a wide-brimmed hat. In some areas of the world where sunny climates are pervasive and exposure to UVR is part of everyday life, fashion trends, policy, and public health initiatives are in sync, and photoprotection with wide-brimmed hats is embraced as a common and fashionable practice...
February 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28306528/protective-effect-of-moringa-oleifera-oil-against-hgcl2-induced-hepato-and-nephro-toxicity-in-rats
#5
Sunny O Abarikwu, Sussan Benjamin, Sunday Godspower Ebah, Godbless Obilor, Goodluck Agbam
BACKGROUND: Various parts of the Moringa oleifera (M. oleifera) tree are widely accepted to have ameliorative effects against metal toxicity. In the present study, M. oleifeira oil (MO) was tested against HgCl2-induced tissue pathologies and oxidative stress. METHODS: Male Wistar rats were administered MO (1.798 mg/kg p.o.) or HgCl2 (5 mg/kg body wt) alone or in combination (5 mg/kg HgCl2+1.798 mg/kg MO p.o.) three times per week for 21 days. After exposure and treatment periods, rats were sacrificed; blood collected and the oxidative status of the liver and kidney homogenates were evaluated...
March 15, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28296592/ethanol-extract-of-capsella-bursa-pastoris-improves-hepatic-steatosis-through-inhibition-of-histone-acetyltransferase-activity
#6
Hyo-Kyoung Choi, Eun Ju Shin, Su Jin Park, Haeng Jeon Hur, Jae Ho Park, Min-Yu Chung, Myung Sunny Kim, Jin-Taek Hwang
Histone lysine acetylation is thought to play a role in regulating the balance between energy storage and energy expenditure. However, the epigenetic mechanisms by which food phytochemicals influence metabolic processes in the liver have not been thoroughly investigated. In this study, we investigated the effect of an ethanol extract of Capsella bursa-pastoris (ECB) on histone acetyltransferase (HAT) inhibition, and whether it could thereby attenuate lipid accumulation in vitro and in vivo. We observed that ECB inhibits HAT activity as assessed by colorimetric and autoradiography assay systems...
March 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28295953/three-dimensional-carbon-nanotube-scaffolds-for-long-term-maintenance-and-expansion-of-human-mesenchymal-stem-cells
#7
Gaurav Lalwani, Michael D'Agati, Anu Gopalan, Sunny C Patel, Yahfi Talukdar, Balaji Sitharaman
Expansion of mesenchymal stem cells (MSCs) and maintenance of their self-renewal capacity in vitro requires specialized robust cell culture systems. Conventional approaches using animal derived or artificial matrices and a cocktail of growth factors have limitations such as consistency, scalability, pathogenicity and loss of MSC phenotype. Herein, we report the use of all-carbon 3D single- and multiwalled carbon nanotube scaffolds (SWCNTs and MWCNTs) as artificial matrices for long-term maintenance and expansion of human MSCs...
March 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28290636/newborn-with-an-arm-deformity
#8
Jaividhya Dasarathy, Vanessa Yeh, Arjun Sunny Dhoopar
No abstract text is available yet for this article.
February 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28285416/a-naturally-occurring-conditional-albino-mutant-in-rice-caused-by-defects-in-the-plastid-localized-osabci8-transporter
#9
Xiuyu Zeng, Ran Tang, Herong Guo, Shanwen Ke, Bin Teng, Yu-Hung Hung, Zhenjiang Xu, Xin-Ming Xie, Tzung-Fu Hsieh, Xiang-Qian Zhang
A wide range of molecules are transported across membranes by the ATP binding cassette (ABC) transporters. Plants possess a collection of ABC proteins bearing similarities to the components of prokaryotic multi subunit ABC transporters, designed as ABC group I. However the functions of most of them are not well understood. Here, we characterized a naturally occurring rice mutant that exhibited albino phenotype under continuous rainy days in the field, but gradually recovered to normal green after the rainy season...
March 11, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28278232/correction-mapping-of-complete-set-of-ribose-and-base-modifications-of-yeast-rrna-by-rp-hplc-and-mung-bean-nuclease-assay
#10
Jun Yang, Sunny Sharma, Peter Watzinger, Johannes David Hartmann, Peter Kötter, Karl-Dieter Entian
[This corrects the article DOI: 10.1371/journal.pone.0168873.].
2017: PloS One
https://www.readbyqxmd.com/read/28272296/performance-of-carbon-nanotube-polysulfone-cnt-psf-composite-membranes-during-oil-water-mixture-separation-effect-of-cnt-dispersion-method
#11
Michael Olawale Daramola, Palesa Hlanyane, Oluwafolakemi O Sadare, Olugbenga O Oluwasina, Sunny E Iyuke
Effect of the dispersion method employed during the synthesis of carbon nanotube (CNT)/polysulfone-infused composite membranes on the quality and separation performance of the membranes during oil-water mixture separation is demonstrated. Carbon nanotube/polysulfone composite membranes containing 5% CNT and pure polysulfone membrane (with 0% CNT) were synthesized using phase inversion. Three CNT dispersion methods referred to as Method 1 (M1), Method 2 (M2), and Method 3 (M3) were used to disperse the CNTs...
March 6, 2017: Membranes
https://www.readbyqxmd.com/read/28264465/peroxisome-proliferator-activated-receptor-%C3%AE-activation-is-not-the-main-contributor-to-teratogenesis-elicited-by-polar-compounds-from-oxidized-frying-oil
#12
Yu-Shun Lin, Ting-Yi Lin, Jia-Jiuan Wu, Hsien-Tsung Yao, Sunny Li-Yun Chang, Pei-Min Chao
We previously reported that polar compounds (PO) in cooking oil are teratogenic and perturbed retinoic acid (RA) metabolism. Considering PO as a potent peroxisome proliferator-activated receptor α (PPARα) activator, this study aimed to investigate the role of PPARα in PO-induced teratogenesis and disturbance of RA metabolism. Female PPARα knockout or wild type mice were mated with males of the same genotype. Pregnant mice were fed a diet containing 10% fat from either fresh oil (FO) or PO from gestational day1 to day18, and killed at day18...
February 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28251663/emotion-dysregulation-and-autonomic-responses-to-film-rumination-and-body-awareness-extending-psychophysiological-research-to-a-naturalistic-clinical-setting-and-a-chemically-dependent-female-sample
#13
Sheila E Crowell, Cynthia J Price, Megan E Puzia, Mona Yaptangco, Sunny Chieh Cheng
Substance use is a complex clinical problem characterized by emotion dysregulation and daily challenges that can interfere with laboratory research. Thus, few psychophysiological studies examine autonomic and self-report measures of emotion dysregulation with multidiagnostic, chemically dependent samples or extend this work into naturalistic settings. In this study, we used a within-subject design to examine changes in respiratory sinus arrhythmia (RSA), electrodermal activity (EDA), and self-reported affect across three tasks designed to elicit distinct psychophysiological and emotional response patterns...
March 2, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28251196/long-persistence-phosphor-assisted-all-weather-solar-cells-electricity-generation-beyond-sunny-days
#14
Jialong Duan, Jing Wang, Qunwei Tang, Benlin He, Wei Wang
We present here a rational design and fabrication for all-weather dye-sensitized solar cells tailored with long-persistence phosphor materials, yielding a maximized photoelectric conversion efficiency of 8.86% under simulated sunlight and up to 26% in the dark.
March 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28249903/non-coding-effects-of-circular-rna-ccdc66-promote-colon-cancer-growth-and-metastasis
#15
Kuei-Yang Hsiao, Ya-Chi Lin, Sachin Kumar Gupta, Ning Chang, Laising Yen, H Sunny Sun, Shaw-Jenq Tsai
Circular RNA (circRNA) is a class of non-coding RNA whose functions remain mostly unknown. Recent studies indicate circRNA may be involved in disease pathogenesis, but direct evidence is scarce. Here we characterize the functional role of a novel circRNA, circCCDC66, in colorectal cancer (CRC). RNA-Seq data from matched normal and tumor colon tissue samples identified numerous circRNAs specifically elevated in cancer cells, several of which were verified by quantitative RT-PCR. CircCCDC66 expression was elevated in polyps and colon cancer and was associated with poor prognosis...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28248290/systems-based-analysis-of-rig-i-dependent-signalling-identifies-khsrp-as-an-inhibitor-of-rig-i-receptor-activation
#16
Stephen Soonthornvacharin, Ariel Rodriguez-Frandsen, Yingyao Zhou, Felipe Galvez, Nicholas J Huffmaster, Shashank Tripathi, Vinod R M T Balasubramaniam, Atsushi Inoue, Elisa de Castro, Hong Moulton, David A Stein, María Teresa Sánchez-Aparicio, Paul D De Jesus, Quy Nguyen, Renate König, Nevan J Krogan, Adolfo García-Sastre, Sunnie M Yoh, Sumit K Chanda
Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5'-triphosphorylated RNA and triggers a signalling cascade that results in the induction of type-I interferon (IFN)-dependent responses. Its precise regulation represents a pivotal balance between antiviral defences and autoimmunity. To elucidate the cellular cofactors that regulate RIG-I signalling, we performed two global RNA interference analyses to identify both positive and negative regulatory nodes operating on the signalling pathway during virus infection...
March 1, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28246036/investigating-the-spatial-extent-of-acoustically-activated-echogenic-liposomes
#17
An T Nguyen, Youhan Sunny, Christopher Bawiec, Peter A Lewin, Steven P Wrenn
The purpose of this work was to investigate the ability of bubbles entrapped within echogenic liposomes (ELIP) to serve as foci for cavitational events that would cause leakage in neighboring non-echogenic liposomes (NELIP). Previous studies have shown that entrapping bubbles into liposomes increases ultrasound-mediated leakage of hydrophilic components at ultrasound settings known to induce inertial cavitation, specifically 20kHz and 2.2W/cm(2). Using tone-burst approach and pulse repetition frequency of 10Hz would bring this intensity level to the one accepted (220mW/cm(2)) in clinical imaging...
January 31, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28224090/vitamin-d-deficiency-insufficiency-from-childhood-to-adulthood-insights-from-a-sunny-country
#18
REVIEW
Motti Haimi, Richard Kremer
Vitamin D is known to be a key regulator of bone metabolism and is associated with muscle strength. Vitamin D deficiency is widely prevalent worldwide. In adults, vitamin D deficiency has been implicated in numerous health conditions including osteoporosis, cancer, diabetes, and autoimmune diseases. Considerable changes have occurred in lifestyles and childhood activities in the past years. Studies have shown that the children population is at high risks of vitamin D deficiency. The objective of this study was to learn about the extent of vitamin D deficiency in children worldwide and especially in sunny country like Israel...
February 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28222903/modified-mrna-vaccines-protect-against-zika-virus-infection
#19
Justin M Richner, Sunny Himansu, Kimberly A Dowd, Scott L Butler, Vanessa Salazar, Julie M Fox, Justin G Julander, William W Tang, Sujan Shresta, Theodore C Pierson, Giuseppe Ciaramella, Michael S Diamond
The emergence of ZIKV infection has prompted a global effort to develop safe and effective vaccines. We engineered a lipid nanoparticle (LNP) encapsulated modified mRNA vaccine encoding wild-type or variant ZIKV structural genes and tested immunogenicity and protection in mice. Two doses of modified mRNA LNPs encoding prM-E genes that produced virus-like particles resulted in high neutralizing antibody titers (∼1/100,000) that protected against ZIKV infection and conferred sterilizing immunity. To offset a theoretical concern of ZIKV vaccines inducing antibodies that cross-react with the related dengue virus (DENV), we designed modified prM-E RNA encoding mutations destroying the conserved fusion-loop epitope in the E protein...
February 16, 2017: Cell
https://www.readbyqxmd.com/read/28216432/epigenetic-modification-by-dietary-factors-implications-in-metabolic-syndrome
#20
REVIEW
Jae-Ho Park, Soon-Hee Kim, Myeong Soo Lee, Myung-Sunny Kim
Dietary factors play a role in normal biological processes and are involved in the regulation of pathological progression over a lifetime. Evidence has emerged indicating that dietary factor-dependent epigenetic modifications can significantly affect genome stability and the expression of mRNA and proteins, which are involved in metabolic dysfunction. Since metabolic syndrome is a progressive phenotype characterized by insulin resistance, obesity, hypertension, dyslipidemia, or type 2 diabetes, gene-diet interactions are important processes involved in the initiation of particular symptoms of metabolic syndrome and their progression...
February 17, 2017: Molecular Aspects of Medicine
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