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https://www.readbyqxmd.com/read/29233423/complementary-and-alternative-medicine-education-in-u-s-schools-and-colleges-of-pharmacy
#1
Alice Scaletta, Nishi Ghelani, Subin Sunny
INTRODUCTION: The objective of this survey is to provide an update on the state of complementary and alternative medicine (CAM) education and describe instructional and assessment methods across schools and colleges of pharmacy. METHODS: One hundred thirty-five schools of pharmacy were contacted to participate in a survey describing the incorporation of CAM education into their respective curricula. The survey also inquired about perceived barriers and future plans for CAM-related courses...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29228022/can-conditional-cash-transfers-improve-the-uptake-of-nutrition-interventions-and-household-food-security-evidence-from-odisha-s-mamata-scheme
#2
Kalyani Raghunathan, Suman Chakrabarti, Rasmi Avula, Sunny S Kim
There is considerable global evidence on the effectiveness of cash transfers in improving health and nutrition outcomes; however, the evidence from South Asia, particularly India, is limited. In the context of India where more than a third of children are undernourished, and where there is considerable under-utilization of health and nutrition interventions, it is opportune to investigate the impact of cash transfer programs on the use of interventions. We study one conditional cash transfer program, Mamata scheme, implemented in the state of Odisha, in India that targeted pregnant and lactating women...
2017: PloS One
https://www.readbyqxmd.com/read/29222426/surveillance-of-antibiotic-resistance-among-common-clostridium-difficile-ribotypes-in-hong-kong
#3
Viola C Y Chow, Thomas N Y Kwong, Erica W M So, Yolanda I I Ho, Sunny H Wong, Raymond W M Lai, Raphael C Y Chan
Incidence of Clostridium difficile infection (CDI) is rapidly increasing and it poses a major health burden globally. However, data regarding the epidemiology of CDI in Asia are limited. We aimed to characterize the antimicrobial susceptibility patterns of common ribotypes of toxigenic C. difficile in Hong Kong. Fifty-three PCR ribotypes were identified among 284 toxigenic C. difficile clinical isolates. The five most prevalent ribotypes were 002 (13%), 017 (12%), 014 (10%), 012 (9.2%), and 020 (9.5%). All tested C...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221985/hotair-mediated-reciprocal-regulation-of-ezh2-and-dnmt1-contribute-to-polyphyllin-i-inhibited-growth-of-castration-resistant-prostate-cancer-cells-in-vitro-and-in-vivo
#4
SongTao Xiang, PeiLiang Zou, Qing Tang, Fang Zheng, JingJing Wu, ZhiQiang Chen, Swei Sunny Hann
BACKGROUND: Polyphyllin I (PPI), one of the steroidal saponins in paris polyphylla, has been reported to exhibit antitumor effects. However, the detailed molecular mechanism underlying this has not been elucidated. METHODS: Cell viability and cell cycle distribution were measured using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and Flow cytometry assays, respectively. Cell invasion and migration were examined by Transwell invasion and wound healing assays...
December 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29215951/regulation-of-aqueous-humor-dynamics-by-hydrogen-sulfide-potential-role-in-glaucoma-pharmacotherapy
#5
Sunny E Ohia, Jenaye Robinson, Leah Mitchell, Kalu K Ngele, Segewkal Heruye, Catherine A Opere, Ya Fatou Njie-Mbye
Hydrogen sulfide (H2S) is a gaseous transmitter with well-known biological actions in a wide variety of tissues and organs. The potential involvement of this gas in physiological and pathological processes in the eye has led to several in vitro, ex vivo, and in vivo studies to understand its pharmacological role in some mammalian species. Evidence from literature demonstrates that 4 enzymes responsible for the biosynthesis of this gas (cystathionine β-synthase, CBS; cystathionine γ-lyase, CSE; 3-mercaptopyruvate sulfurtransferase, 3MST; and d-amino acid oxidase) are present in the cornea, iris, ciliary body, lens, and retina...
December 7, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29215354/associations-between-extreme-precipitation-and-acute-gastro-intestinal-illness-due-to-cryptosporidiosis-and-giardiasis-in-an-urban-canadian-drinking-water-system-1997-2009
#6
Bimal K Chhetri, Tim K Takaro, Robert Balshaw, Michael Otterstatter, Sunny Mak, Marcus Lem, Marc Zubel, Mark Lysyshyn, Len Clarkson, Joanne Edwards, Manon D Fleury, Sarah B Henderson, Eleni Galanis
Drinking water related infections are expected to increase in the future due to climate change. Understanding the current links between these infections and environmental factors is vital to understand and reduce the future burden of illness. We investigated the relationship between weekly reported cryptosporidiosis and giardiasis (n = 7,422), extreme precipitation (>90th percentile), drinking water turbidity, and preceding dry periods in a drinking water system located in greater Vancouver, British Columbia, Canada (1997-2009) using distributed lag non-linear Poisson regression models adjusted for seasonality, secular trend, and the effect of holidays on reporting...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29212910/foxp1-negatively-regulates-t-follicular-helper-cell-differentiation-and-germinal-center-responses-by-controlling-cell-migration-and-ctla-4
#7
Bi Shi, Jianlin Geng, Yin-Hu Wang, Hairong Wei, Beth Walters, Wei Li, Xuerui Luo, Anna Stevens, Melanie Pittman, Bin Li, Sunnie R Thompson, Hui Hu
T follicular helper (Tfh) cells play an essential role in the formation of germinal centers (GC) and generation of high-affinity Abs. The homing of activated CD4+ T cells into B cell follicles and the involvement of key costimulatory and coinhibitory molecules are critical in controlling both the initiation and the magnitude of GC responses. Meanwhile, studies have shown that a high number of single clone B cells leads to intraclonal competition, which inhibits the generation of high-affinity Abs. Our previous work has shown that transcription factor Foxp1 is a critical negative regulator of Tfh cell differentiation...
December 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29210489/effects-of-temperature-and-photorepair-radiation-on-a-marine-ciliate-exposed-to-uvb-radiation
#8
Sarah E Hamsher, Cheng Yun Tina Sung, Robert W Sanders
The influences of intensity and repeated exposure to ultraviolet-B radiation (UVB), photoreactivating repair radiation (PRR), and temperature on the scuticociliate Parauronema acutum were explored under laboratory conditions. Population growth was negatively affected after exposure to the equivalent of one sunny summer day of ambient UVB, especially in the absence of PRR. Repeated daily exposure to UVB severely compromised ciliate survival. UVB-exposed treatments without PRR recovered slower and reached lower final abundances than treatments receiving PRR...
December 6, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/29200060/changing-default-ventilator-settings-on-anesthesia-machines-improves-adherence-to-lung-protective-ventilation-measures
#9
Sunny S Chiao, Douglas A Colquhoun, Bhiken I Naik, Jennie Z Ma, Edward C Nemergut, Marcel E Durieux, Randal S Blank, Katherine T Forkin
Perioperative lung-protective ventilation (LPV) can reduce perioperative pulmonary morbidity. We hypothesized that modifying default anesthesia machine ventilator settings would increase the use of intraoperative LPV. Default tidal volume settings on our anesthesia machines were decreased from 600 to 400 mL, and default positive end-expiratory pressure was increased from 0 to 5 cm H2O. This modification increased mean positive end-expiratory pressure from 3.1 to 5.0 cm H2O and decreased mean tidal volume from 8...
November 30, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29199718/multiple-myeloma-experience-of-an-institute-in-limited-resource-setting
#10
Linu Abraham Jacob, M C Suresh Babu, K C Lakshmaiah, K Govind Babu, D Lokanatha, L K Rajeev, K N Lokesh, A H Rudresha, Ankit Agarwal, Sunny Garg
INTRODUCTION: Multiple myeloma (MM) is a plasma cell dyscrasias and an incurable clonal B-cell malignancy, with an annual incidence of 1% of all malignancies. The mainstay of treatment of myeloma is induction treatment followed by consolidation with autologous stem cell transplant (ASCT). However, still in a developing country like India where affordability is a major hurdle for health care, a number of MM patients are not able to undergo ASCT. AIM: To study the epidemiological features and outcome of MM patients treated in a limited resource setting...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29196859/validation-of-simplified-postoperative-nausea-and-vomiting-intensity-scale-in-taiwan
#11
Hsun-Chang Shin, Ting-Wei Kang, Yu Hua Wu, H Sunny Sun, Chia-Chih Alex Tseng
This study determined whether the Simplified Postoperative Nausea and Vomiting Impact Scale (SPONVIS), could be used to predict clinically important PONV in Taiwanese. In this prospective, observational study, SPONVIS, simplified Apfel PONV Risk Scores, post-operative anti-emetic drug use, total PONV score, and 3-month recall score for PONV were recorded from Taiwanese patients who had undergone general anesthesia and surgery. With antiemetic use and 3-month recall score as validations of clinical significance, we determined whether the elements and cut-off points used in the original SPONVIS study could be used in Taiwanese patients...
December 1, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29191327/optogenetic-modulation-of-cardiac%C3%A2-sympathetic-nerve-activity-to%C3%A2-prevent-ventricular%C3%A2-arrhythmias
#12
Lilei Yu, Liping Zhou, Gang Cao, Sunny S Po, Bing Huang, Xiaoya Zhou, Menglong Wang, Shenxu Yuan, Zhuo Wang, Songyun Wang, Hong Jiang
BACKGROUND: Studies have shown that left stellate ganglion (LSG) suppression protects against ventricular arrhythmias (VAs). Optogenetics is a novel technique to reversibly regulate the activity of the targeted neurons. OBJECTIVES: This study aimed to investigate whether an optogenetically silenced LSG could protect against VAs induced by myocardial ischemia. METHODS: Adeno-associated virus (AAV) was used as the vector to deliver ArchT, an inhibitory light-sensitive opsin, to the LSG neurons...
December 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29190401/addressing-food-insecurity-in-family-medicine-and-medical-education
#13
Sunny Smith, David Malinak, Jinnie Chang, Amanda Schultz, Kristin Brownell
BACKGROUND AND OBJECTIVES: Food insecurity is associated with poor health outcomes, yet is not routinely addressed in health care. This study was conducted to determine if education regarding food insecurity as a health issue could modify knowledge, attitudes, and clinical behavior. METHODS: Educational sessions on food insecurity and its impact on health were conducted in 2015 at three different family medicine residency programs and one medical school. A pre/post survey was given immediately before and after this session...
November 2017: Family Medicine
https://www.readbyqxmd.com/read/29185233/estimating-prevalence-and-healthcare-utilization-for-treatment-resistant-depression-in-japan-a-retrospective-claims-database-study
#14
Jörg Mahlich, Sunny Tsukazawa, Frank Wiegand
BACKGROUND: Major depressive disorders (MDDs) including treatment-resistant depression (TRD) are common disabling conditions, but data on their epidemiology in Japan are limited. This study investigated the incidence, epidemiology, and direct medical costs of TRD and pharmaceutically-treated depression (PTD) in Japan to increase our health economic understanding of this phenotype of MDD. METHODS: A retrospective cohort study from a private health insurance claims database estimated the 1-year incidence of PTD and TRD and described the health services used and direct medical costs associated with these conditions...
November 28, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29180820/subcutaneous-white-adipocytes-express-a-light-sensitive-signaling-pathway-mediated-via-a-melanopsin-trpc-channel-axis
#15
Katarina Ondrusova, Mohammad Fatehi, Amy Barr, Zofia Czarnecka, Wentong Long, Kunimasa Suzuki, Scott Campbell, Koenraad Philippaert, Matthew Hubert, Edward Tredget, Peter Kwan, Nicolas Touret, Martin Wabitsch, Kevin Y Lee, Peter E Light
Subcutaneous white adipose tissue (scWAT) is the major fat depot in humans and is a central player in regulating whole body metabolism. Skin exposure to UV wavelengths from sunlight is required for Vitamin D synthesis and pigmentation, although it is plausible that longer visible wavelengths that penetrate the skin may regulate scWAT function. In this regard, we discovered a novel blue light-sensitive current in human scWAT that is mediated by melanopsin coupled to transient receptor potential canonical cation channels...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29180436/broad-detection-of-bacterial-type-iii-secretion-system-and-flagellin-proteins-by-the-human-naip-nlrc4-inflammasome
#16
Valeria M Reyes Ruiz, Jasmine Ramirez, Nawar Naseer, Nicole M Palacio, Ingharan J Siddarthan, Brian M Yan, Mark A Boyer, Daniel A Pensinger, John-Demian Sauer, Sunny Shin
Inflammasomes are cytosolic multiprotein complexes that initiate host defense against bacterial pathogens by activating caspase-1-dependent cytokine secretion and cell death. In mice, specific nucleotide-binding domain, leucine-rich repeat-containing family, apoptosis inhibitory proteins (NAIPs) activate the nucleotide-binding domain, leucine-rich repeat-containing family, CARD domain-containing protein 4 (NLRC4) inflammasome upon sensing components of the type III secretion system (T3SS) and flagellar apparatus...
November 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29179681/low-flow-extracorporeal-co2-removal-in-ards-patients-a-prospective-short-term-crossover-pilot-study
#17
Harlinde Peperstraete, Sunny Eloot, Pieter Depuydt, Filip De Somer, Carl Roosens, Eric Hoste
BACKGROUND: Lung protective mechanical ventilation (MV) is the corner stone of therapy for ARDS. However, its use may be limited by respiratory acidosis. This study explored feasibility of, effectiveness and safety of low flow extracorporeal CO2 removal (ECCO2R). METHODS: This was a prospective pilot study, using the Abylcap® (Bellco) ECCO2R, with crossover off-on-off design (2-h blocks) under stable MV settings, and follow up till end of ECCO2R. Primary endpoint for effectiveness was a 20% reduction of PaCO2 after the first 2-h...
November 28, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29179155/patterns-of-adverse-childhood-experiences-and-substance-use-among-young-adults-a-latent-class-analysis
#18
Sunny H Shin, Shelby Elaine McDonald, David Conley
INTRODUCTION: Adverse childhood experiences (ACEs) have been strongly linked with subsequent substance use. The aim of this study was to investigate how different patterns of ACEs influence substance use in young adulthood. METHODS: Using a community sample of young individuals (N=336; ages 18-25), we performed latent class analyses (LCA) to identify homogenous groups of young people with similar patterns of ACEs. Exposure to ACEs incorporates 13 childhood adversities including childhood maltreatment, household dysfunction, and community violence...
November 13, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29176904/mobile-microscopy-as-a-screening-tool-for-oral-cancer-in-india-a-pilot-study
#19
Arunan Skandarajah, Sumsum P Sunny, Praveen Gurpur, Clay D Reber, Michael V D'Ambrosio, Nisheena Raghavan, Bonney Lee James, Ravindra D Ramanjinappa, Amritha Suresh, Uma Kandasarma, Praveen Birur, Vinay V Kumar, Honorius-Cezar Galmeanu, Alexandru Mihail Itu, Mihai Modiga-Arsu, Saskia Rausch, Maria Sramek, Manohar Kollegal, Gianluca Paladini, Moni Kuriakose, Lance Ladic, Felix Koch, Daniel Fletcher
Oral cancer is the most common type of cancer among men in India and other countries in South Asia. Late diagnosis contributes significantly to this mortality, highlighting the need for effective and specific point-of-care diagnostic tools. The same regions with high prevalence of oral cancer have seen extensive growth in mobile phone infrastructure, which enables widespread access to telemedicine services. In this work, we describe the evaluation of an automated tablet-based mobile microscope as an adjunct for telemedicine-based oral cancer screening in India...
2017: PloS One
https://www.readbyqxmd.com/read/29174966/pentraxin-3-as-a-marker-of-sepsis-severity-and-predictor-of-mortality-outcomes-a-systematic-review-and-meta-analysis
#20
Yee Ting Lee, Mengqi Gong, Alex Chau, Wing Tak Wong, George Bazoukis, Sunny Hei Wong, William K K Wu, Konstantinos Lampropoulos, Yunlong Xia, Guangping Li, Martin C S Wong, Tong Liu, Gary Tse
OBJECTIVES: Pentraxin-3 (PTX-3) is a multi-functional pattern recognition molecule produced by various cell types of peripheral tissues in different infections. It is raised in sepsis, but its values in predicting disease severity or mortality outcomes have been controversial. Therefore, we conducted a systematic review and meta-analysis of these associations. METHODS: PubMed and Embase were searched until 18th July 2017 for studies that evaluated the relationship between PTX-3 levels and disease severity or mortality in sepsis...
November 23, 2017: Journal of Infection
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