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https://www.readbyqxmd.com/read/29684454/process-desired-functional-attributes-of-anendoxylanase-of-gh10-family-from-a-new-strain-of-aspergillus-terreus-s9
#1
Sunny Sharma, Vishal Sharma, Parushi Nargotra, Bijender Kumar Bajaj
Huge industrial application potential of xylanases is stalled due to lack of process suitable characteristics like thermostability, broad range pH stability, and high catalytic efficiency in the available enzymes. Current study presents the first ever report of a pH stable (pH 6-11) and thermostable (80-100 °C) xylanase from a novel strain of Aspergillus terreus S9. The xylanase was purified to homogeneity (6.67-fold) by ammonium sulphate precipitation, ion exchange chromatography, and molecular exclusion chromatography...
April 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29682180/glycogen-debranching-enzyme-agl-is-a-novel-regulator-of-non-small-cell-lung-cancer-growth
#2
Craig S Richmond, Darby Oldenburg, Garrett Dancik, David R Meier, Benjamin Weinhaus, Dan Theodorescu, Sunny Guin
Glycogen debranching enzyme (AGL) and Glycogen phosphorylase (PYG) are responsible for glycogen breakdown. We have earlier shown that AGL is a regulator of bladder tumor growth. Here we investigate the role of AGL in non-small cell lung cancers (NSCLC). Short hairpin RNA (shRNA) driven knockdown of AGL resulted in increased anchorage independent and xenograft growth of NSCLC cells. We further establish that an increase in hyaluronic acid (HA) synthesis driven by Hyaluronic Acid Synthase 2 (HAS2) is critical for anchorage independent growth of NSCLC cells with AGL loss...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681005/analytical-review-of-contemporary-fatwas-in-resolving-biomedical-issues-over-gender-ambiguity
#3
Taqwa Zabidi
Issues of gender ambiguity have been discussed over time from both Islamic and medical perspectives. In Islam, these issues are typically considered in the context of khunūthah (literally translated as hermaphroditism). While biomedical studies have appeared to provide a large amount of information on abnormal human biological development, i.e. Disorders of Sex Development (DSDs). However, the connection between these two fields has been given little attention. This research aims to determine the Islamic underpinnings through the fatwa around the globe...
April 21, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29675972/the-american-academy-of-nursing-jonas-policy-scholars-program-mentoring-future-nurse-leaders-to-advance-health-policy
#4
EDITORIAL
Sarah Oerther, Sunny Hallowell, Alicia Rossiter, Deborah Gross
In 2010, the Institute of Medicine released a landmark report, "The Future of Nursing: Leading Change, Advancing Health," calling for a transformation of the nursing profession in education, leadership, and practice (Institute of Medicine [IOM], 2010). Consistent with the call to transform nursing and its role in health and health care, the American Academy of Nursing (the Academy), an organization of approximately 2,500 nursing leaders from around the world, created the Jonas Policy Scholars Program...
April 20, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29673411/dietary-minerals-reproductive-hormone-levels-and-sporadic-anovulation-associations-in-healthy-women-with-regular-menstrual-cycles
#5
Keewan Kim, Jean Wactawski-Wende, Kara A Michels, Karen C Schliep, Torie C Plowden, Ellen N Chaljub, Sunni L Mumford
Although minerals are linked to several reproductive outcomes, it is unknown whether dietary minerals are associated with ovulatory function. We hypothesised that low intakes of minerals would be associated with an increased risk of anovulation. We investigated associations between dietary mineral intake and both reproductive hormones and anovulation in healthy women in the BioCycle Study, which prospectively followed up 259 regularly menstruating women aged 18-44 years who were not taking mineral supplements for two menstrual cycles...
April 20, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29668891/maternal-polycystic-ovarian-syndrome-and-early-offspring-development
#6
Griffith A Bell, Rajeshwari Sundaram, Sunni L Mumford, Hyojun Park, James Mills, Erin M Bell, Miranda Broadney, Edwina H Yeung
STUDY QUESTION: Is maternal polycystic ovarian syndrome (PCOS) associated with developmental delays in offspring? SUMMARY ANSWER: Offspring of mothers with PCOS were at higher risk of failure on the Ages and Stages Questionnaire (ASQ). WHAT IS KNOWN ALREADY: There is growing evidence that offspring of mothers with PCOS may be at higher risk for developmental disorders due to potential exposure to hyperandrogenism and insulin resistance. Few studies exist regarding maternal PCOS and early childhood development in the USA...
April 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29667728/comparison-of-10-efficient-protocols-for-photodynamic-therapy-of-actinic-keratosis-how-relevant-are-effective-light-dose-and-local-damage-in-predicting-the-complete-response-rate-at-3-months
#7
Anne-Sophie Vignion-Dewalle, Gregory Baert, Elise Thecua, Fabienne Lecomte, Claire Vicentini, Henry Abi-Rached, Laurent Mortier, Serge Mordon
BACKGROUND: Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu-U illuminator is approved in the United States. Many other protocols using irradiation by a variety of light sources are also clinically efficient. OBJECTIVES: This paper aims to compare 10 different protocols with clinically proven efficacy for photodynamic therapy of actinic keratosis and the available spectral irradiance of the light source...
April 18, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29667034/thermal-comfort-along-the-marathon-course-of-the-2020-tokyo-olympics
#8
Tsuyoshi Honjo, Yuhwan Seo, Yudai Yamasaki, Nobumitsu Tsunematsu, Hitoshi Yokoyama, Hiroaki Yamato, Takehiko Mikami
The Olympic Games will be held in Tokyo in 2020 and the period will be the hottest period of the year in Japan. Marathon is a sport with a large heat load, and it is said that the risk of heat stroke rises more than other sports activities. The thermal environment of the 2020 Tokyo Olympic marathon course is analyzed by using wet-bulb globe temperature (WBGT) and Universal Thermal Climate Index (UTCI) map of the center area of Tokyo. The change due to the place, the effect of the shadow of the building, and the position on the course was analyzed from the distribution of WBGT and UTCI in the short-term analysis of sunny day from August 2 to August 6, 2014...
April 17, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29666767/present-and-future-ecological-niche-modeling-of-garter-snake-species-from-the-trans-mexican-volcanic-belt
#9
Andrea González-Fernández, Javier Manjarrez, Uri García-Vázquez, Maristella D'Addario, Armando Sunny
Land use and climate change are affecting the abundance and distribution of species. The Trans-Mexican Volcanic Belt (TMVB) is a very diverse region due to geological history, geographic position, and climate. It is also one of the most disturbed regions in Mexico. Reptiles are particularly sensitive to environmental changes due to their low dispersal capacity and thermal ecology. In this study, we define the important environmental variables (considering climate, topography, and land use) and potential distribution (present and future) of the five Thamnophis species present in TMVB...
2018: PeerJ
https://www.readbyqxmd.com/read/29663475/subtle-changes-in-menstrual-cycle-function-pieces-of-the-puzzle
#10
Sunni L Mumford, Keewan Kim
No abstract text is available yet for this article.
April 16, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29659783/managed-fire-frequency-significantly-influences-the-litter-arthropod-community-in-longleaf-pine-flatwoods
#11
Rachel A Atchison, Jiri Hulcr, Andrea Lucky
Frequent prescribed burns are essential to pine forest restoration and management. Research studies have assessed effects of prescribed fire and burn frequency on plants and vertebrates, but impacts of fire on terrestrial invertebrate communities are still poorly understood. This case study investigated effects of burning frequency on species richness and community composition of social insects (ants, Hymenoptera: Formicidae and termites, Blattodea: Isoptera) in fire-managed Southern longleaf pine flatwoods in central Florida...
April 11, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29656488/importance-of-coverage-and-quality-for-impact-of-nutrition-interventions-delivered-through-an-existing-health-programme-in-bangladesh
#12
Phuong Hong Nguyen, Edward A Frongillo, Tina Sanghvi, Sunny S Kim, Silvia Alayon, Lan Mai Tran, Zeba Mahmud, Bachera Aktar, Purnima Menon
Understanding implementation of interventions is critical to illuminate if, how, and why the interventions achieve impact. Alive & Thrive integrated a nutrition intervention into an existing maternal, neonatal, and child health (MNCH) programme in Bangladesh, documenting improvements in women's micronutrient supplement intake and dietary diversity. Here, we examined how well the nutrition intervention was implemented and which elements of implementation explained intervention impact. Survey data were collected in 2015 and 2016 from frontline health workers (FLW) and households in areas randomized to nutrition-focused MNCH (intensified interpersonal counselling, community mobilization, distribution of free micronutrient supplements, and weight-gain monitoring) or standard MNCH (antenatal care with standard nutrition counselling)...
April 14, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29653158/mice-deficient-in-akap13-brx-develop-compulsive-like-behavior-and-increased-body-weight
#13
K Maravet Baig, Szu-Chi Su, Sunni L Mumford, Emma Giuliani, Sinnie Sin Man Ng, Charles Armstrong, Margaret F Keil, Kamaria Cayton Vaught, Nils Olsen, Elyse Pettiford, Irina Burd, James H Segars
OBJECTIVE: Hormonal contributions to the sex-dependent development of both obsessive-compulsive disorder (OCD) and obesity have been described, but the underlying mechanisms are incompletely understood. A-kinase anchoring protein 13 (AKAP13) significantly augments ligand-dependent activation of estrogen receptors alpha and beta. The hypothalamus and pituitary gland are implicated in the development and exacerbation of OCD and obesity and have strong AKAP13 expression. The AKAP13 localization pattern observed in these key brain regions together with its effects on sex steroid action suggest a potential role for AKAP13 in compulsive-like behaviors...
April 10, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29651590/effect-of-long-term-acclimatization-on-summer-thermal-comfort-in-outdoor-spaces-a-comparative-study-between-melbourne-and-hong-kong
#14
Cho Kwong Charlie Lam, Kevin Ka-Lun Lau
The Universal Thermal Climate Index (UTCI) is an index for assessing outdoor thermal environment which aims to be applicable universally to different climates. However, the scale of UTCI thermal stress classification can be interpreted depending on the context. Previous studies validated the UTCI in individual cities, but comparative studies between different cities are scarce. This study examines the differences in thermal perception and clothing choices between residents from two climate zones over similar UTCI ranges in summer...
April 12, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29648647/a-prospective-study-of-physical-activity-and-fecundability-in-women-with-a-history-of-pregnancy-loss
#15
Lindsey M Russo, Brian W Whitcomb, Sunni L Mumford, Marquis Hawkins, Rose G Radin, Karen C Schliep, Robert M Silver, Neil J Perkins, Keewan Kim, Ukpebo R Omosigho, Daniel L Kuhr, Tiffany L Holland, Lindsey A Sjaarda, Enrique F Schisterman
STUDY QUESTION: Is physical activity (PA) associated with fecundability in women with a history of prior pregnancy loss? SUMMARY ANSWER: Higher fecundability was related to walking among overweight/obese women and to vigorous PA in women overall. WHAT IS KNOWN ALREADY: PA may influence fecundability through altered endocrine function. Studies evaluating this association have primarily utilized Internet-based recruitment and self-report for pregnancy assessment and have yielded conflicting results...
April 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29644807/factors-influencing-the-uptake-of-a-mass-media-intervention-to-improve-child-feeding-in-bangladesh
#16
Sunny S Kim, Terry Roopnaraine, Phuong H Nguyen, Kuntal K Saha, Mahbubul I Bhuiyan, Purnima Menon
Mass media are increasingly used to deliver health messages to promote social and behaviour change, but there has been little evidence of mass media use for improving a set of child feeding practices, other than campaigns to promote breastfeeding. This study aimed to examine the factors influencing the uptake of infant and young child feeding messages promoted in TV spots that were launched and aired nationwide in Bangladesh. We conducted a mixed-methods study, using household surveys (n = 2,000) and semistructured interviews (n = 251) with mothers of children 0-23...
April 11, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29644574/erratum-to-percutaneous-mitral-valve-interventions-and-heart-failure
#17
Abhishek Sharma, Sunny Goel, Sahil Agrawal
No abstract text is available yet for this article.
April 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29644037/obstructive-hydrocephalus-secondary-to-odontoid-pannus-case-report-and-review-of-literature
#18
Wai Cheong Soon, Gopiga Thanabalasundaram, Kyaw Zayar Thant, Ebere Sunny Ogbonnaya, Stuart Edward Harrisson
Odontoid pannus or periodontoid pseudotumour is associated with a variety of rheumatological conditions. We report a case of an 80-year old man who presented with acute hydrocephalus following an emergency operation to amputate his infected left big toe. Imaging revealed a large tissue mass causing severe compression at the cervico-medullary junction and obstruction of CSF flow. The acute hydrocephalus was presumed to be related to neck manoeuvring during general anaesthesia. Following an initial emergency CSF diversion through external ventricular drainage catheter insertion, the patient subsequently underwent ventriculo-peritoneal insertion and posterior spinal decompression and fixation...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29642940/multi-cohort-analysis-of-colorectal-cancer-metagenome-identified-altered-bacteria-across-populations-and-universal-bacterial-markers
#19
Zhenwei Dai, Olabisi Oluwabukola Coker, Geicho Nakatsu, William K K Wu, Liuyang Zhao, Zigui Chen, Francis K L Chan, Karsten Kristiansen, Joseph J Y Sung, Sunny Hei Wong, Jun Yu
BACKGROUND: Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to the tumorigenesis. The potential use of gut microbes as markers for early diagnosis has also been reported. However, cohort specific noises may distort the structure of microbial dysbiosis in CRC and lead to inconsistent results among studies. In this regard, our study targeted at exploring changes in gut microbiota that are universal across populations at species level...
April 11, 2018: Microbiome
https://www.readbyqxmd.com/read/29627917/autosomal-short-tandem-repeat-variations-and-population-genetic-data-on-23-systems-in-seven-major-subpopulations-from-lebanon
#20
Ansar El Andari, Mira Khazzouh, Issam Mansour
Population allele frequency is an indicator of population genetic diversity and plays significant roles in DNA profiling interpretation in human identification, kinship, and forensic testing. The Lebanese population is a mosaic of 18 religious communities with high rates of consanguinity and endogamy. Allele frequencies for 23 STR loci were estimated and analyzed in the seven major Lebanese religious subcommunities (Muslims Shiaa, Sunni, and Druze, and Christians Orthodox, Maronite, and Catholics), to assess possible significant differences among their STR allele frequencies...
April 7, 2018: International Journal of Legal Medicine
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