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https://www.readbyqxmd.com/read/29048724/longitudinal-perspectives-on-the-psychosis-spectrum-in-22q11-2-deletion-syndrome
#1
REVIEW
Sunny X Tang, Raquel E Gur
The prevalence of psychotic disorders in individuals with 22q11.2 Deletion Syndrome (22q11DS) reaches 25-35% in young adulthood and may provide a neurogenetic model for clinical risk of psychotic disorders in the general population. This review focuses on prospective longitudinal studies in 22q11DS, which capture fluctuations in psychosis symptoms over time and may provide insights into potential demographic, clinical, cognitive, and neuroimaging predictors of psychosis-spectrum outcomes in the general population...
October 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29048595/ultraviolet-radiation-and-skin-cancer-risk-in-offshore-workers
#2
J S Stenehjem, T E Robsahm, M Bråtveit, S O Samuelsen, J Kirkeleit, T K Grimsrud
Background: Excess skin cancer mortality and incidence have been reported among both land-based and offshore petroleum workers. The association between skin cancer and ultraviolet radiation (UVR) exposure has not been examined in these workers, although they have long off-duty periods and high average income that may allow travelling to sunny destinations. In addition, they have access to solariums free of charge on many accommodation platforms. Aims: To prospectively examine risk of incident cutaneous melanoma (CM) and non-melanoma skin cancer (NMSC), according to sun-tanning habits with adjustment for aromatic hydrocarbon exposure...
October 1, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29045890/a-rhim-with-a-view-flying-with-functional-amyloids
#3
Sunny Shin, Sara Cherry
Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins. Amyloid formation can be negatively regulated, suggesting that it presents a regulatory point in multiple biological processes.
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29044160/eosinophilia-and-clinical-outcome-of-chronic-obstructive-pulmonary-disease-a-meta-analysis
#4
Jeffery Ho, Wajia He, Matthew T V Chan, Gary Tse, Tong Liu, Sunny H Wong, Czarina C H Leung, Wai T Wong, Sharon Tsang, Lin Zhang, Rose Y P Chan, Tony Gin, Joseph Leung, Benson W M Lau, William K K Wu, Shirley P C Ngai
Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles indexed in four databases using Medical Subject Heading or Title and Abstract words including COAD, COPD, eosinophil, eosinophilia, eosinopenia from inception to December 2016. Observational studies and randomized controlled trials with parallel groups comparing COPD patients with and without eosinophilia were included...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042254/cardiac-sodium-channel-antagonism-translation-of-preclinical-in-vitro-assays-to-clinical-qrs-prolongation
#5
Stephen Jenkinson, Asser Bassyouni, Jason Cordes, Bernard Fermini, Donglin Guo, David M Potter, David S Ramirez, Jill Steidl-Nichols, Sunny Sun, Todd Wisialowski
INTRODUCTION: Cardiac sodium channel antagonists have historically been used to treat cardiac arrhythmias by preventing the reentry of the electrical impulse that could occur following myocardial damage. However, clinical studies have highlighted a significant increase in mortality associated with such treatment. Cardiac sodium channel antagonist activity is now seen as an off-target pharmacology that should be mitigated during the drug development process. The aim of this study was to examine the correlation between in vitro/ex vivo assays that are routinely used to measure Nav1...
October 14, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29040797/attention-deficit-hyperactivity-disorder-symptoms-and-psychosis-in-22q11-2-deletion-syndrome
#6
Maria Niarchou, Monica E Calkins, Tyler M Moore, Sunny X Tang, Donna M McDonald-McGinn, Elaine H Zackai, Beverly S Emanuel, Ruben C Gur, Raquel E Gur
OBJECTIVE: 22q11.2 Deletion Syndrome (22q11.2DS) is associated with increased risk for schizophrenia in adulthood while Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent diagnosis in childhood. Inattention symptoms are pronounced in 22q11.2DS and given that attentional impairment is a core feature of schizophrenia, inattention symptoms may reflect underlying ADHD, psychosis, or both. We investigate whether inattention is associated with psychosis in 22q11.2DS and in other groups at risk for psychosis but without the deletion (ND) (idiopathic clinical risk and first degree family members of individuals with schizophrenia)...
October 10, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29037369/ambient-temperature-and-humidity-modulate-the-behavioural-thermoregulation-of-a-small-arboreal-mammal-callicebus-bernhardi
#7
Karine G D Lopes, Júlio César Bicca-Marques
Maintaining a constant body temperature is critical to the proper functioning of metabolic reactions. Behavioural thermoregulation strategies may minimize the cost of energetic balance when an animal is outside its thermoneutral zone. We investigated whether ambient temperature and relative air humidity influence the use of behavioural strategies by a group of Prince Bernhard's titi monkeys (Callicebus bernhardi) living in a forest fragment. We monitored a social group composed of four individuals (an adult couple and two juveniles) for 1010h from March to September 2015...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29036741/the-effects-of-aspirin-in-gestation-and-reproduction-eager-trial-a-story-of-discovery
#8
Matthew T Connell, Lindsey A Sjaarda, Rose G Radin, Daniel Kuhr, Sunni L Mumford, Torie C Plowden, Robert M Silver, Enrique F Schisterman
No abstract text is available yet for this article.
July 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/29030687/tolerability-of-bisoprolol-on-domiciliary-spirometry-in-copd
#9
Sunny Jabbal, Brian J Lipworth
We investigated if serial domiciliary measures of spirometry were sensitive at detecting subtle effects of beta-2 blockade associated with bisoprolol in (n = 17) patients with COPD. After a two-week run in on inhaled corticosteroid (ICS) and long acting beta-2 agonist (LABA): beclometasone/formoterol 100/6 µg, patients' started additional a long acting muscarinic receptor antagonist: (LAMA) Tiotropium 18 µg, with concomitant weekly dose titration of bisoprolol: 1.25-2.5-5 mg. After a further week of bisoprolol 5 mg, they were stepped back down to (ICS/LABA) for one week...
October 14, 2017: Lung
https://www.readbyqxmd.com/read/29028803/scale-of-body-connection-a-multi-sample-construct-validation-study
#10
Cynthia J Price, Elaine Adams Thompson, Sunny Chieh Cheng
The Scale of Body Connection (SBC) was created to address the need for a self-report measure to examine body awareness and bodily dissociation in mind-body research. Developed in the U.S.A., it has been translated into many languages and tested for validity of scale translation. The burgeoning of mind-body research and the widespread use of the SBC scale underscored the need for critical assessment of the instrument's measurement properties. Thus, a broader evaluation of the SBC was designed using large samples from eight international, cross-sectional studies drawn from community (i...
2017: PloS One
https://www.readbyqxmd.com/read/29025321/rutin-ameliorates-oxidative-stress-and-preserves-hepatic-and-renal-functions-following-exposure-to-cadmium-and-ethanol
#11
Sunny O Abarikwu, Rex-Clovis Njoku, Chiamaka J Lawrence, Iniobong A Charles, Jude C Ikewuchi
CONTEXT: Rutin (RUT) is an antioxidant flavonoid with well-known metal chelating potentials. OBJECTIVE: This study was designed to evaluate the protective effects of RUT against cadmium (Cd) + ethanol (EtOH)-induced hepatic and renal toxicity in rats. MATERIALS AND METHODS: Wistar rats were treated with Cd (50 mg/kg) alone or in combination with EtOH (5 mg/kg) and RUT (25, 50 and 100 mg/kg) for 15 days. After treatment, the liver, kidney and serum were removed for biochemical assays by spectrophotometric methods...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29024194/disrupted-cortico-limbic-connectivity-during-reward-processing-in-remitted-bipolar-i-disorder
#12
Sunny J Dutra, Vincent Man, Hedy Kober, William A Cunningham, June Gruber
OBJECTIVES: Bipolar disorder (BD) is associated with elevated reward sensitivity and persistent positive affect, yet the neural mechanisms underlying these patterns are not well understood. In the present study, we examined putative disruptions in communication within a well-known cortico-limbic reward circuit during reward processing as a potential contributing mechanism to these symptoms. METHODS: The present investigation employed a within- and between-subjects design utilizing a monetary and social incentive delay task among adults with bipolar disorder type I (BD; N = 24) and a healthy non-psychiatric control group (HC; N = 25) during functional magnetic resonance imaging (fMRI)...
October 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29023481/phytochemical-residue-profiles-in-rice-grains-fumigated-with-essential-oils-for-the-control-of-rice-weevil
#13
S Ezhil Vendan, S Manivannan, Anila M Sunny, R Murugesan
In the present study, we investigated the fumigant potential of five edible essential oils (EOs) against Sitophilus oryzae and their phytochemical residues in treated grains. Among the tested EOs, peppermint oil proved significantly effective (P ≤ 0.05) on S.oryzae at 400 μl/L air concentration, inducing 83 and 100% mortalities in with-food and without-food conditions respectively over 72 h exposure. In addition, it was also observed that the binary mixtures of peppermint + lemon oil (1:1 ratio) produced an equivalent effect to that of peppermint oil alone treatments...
2017: PloS One
https://www.readbyqxmd.com/read/29021370/integrating-nutrition-interventions-into-an-existing-maternal-neonatal-and-child-health-program-increased-maternal-dietary-diversity-micronutrient-intake-and-exclusive-breastfeeding-practices-in-bangladesh-results-of-a-cluster-randomized-program-evaluation
#14
Phuong Hong Nguyen, Sunny S Kim, Tina Sanghvi, Zeba Mahmud, Lan Mai Tran, Sadia Shabnam, Bachera Aktar, Raisul Haque, Kaosar Afsana, Edward A Frongillo, Marie T Ruel, Purnima Menon
Background: Maternal undernutrition is a major concern globally, contributing to poor birth outcomes. Limited evidence exists on delivering multiple interventions for maternal nutrition simultaneously. Alive & Thrive addressed this gap by integrating nutrition-focused interpersonal counseling, community mobilization, distribution of free micronutrient supplements, and weight-gain monitoring through an existing Maternal, Neonatal, and Child Health (MNCH) program in Bangladesh.Objectives: We evaluated the effect of providing nutrition-focused MNCH compared with standard MNCH (antenatal care with standard nutrition counseling) on coverage of nutrition interventions, maternal dietary diversity, micronutrient supplement intake, and early breastfeeding practices...
October 11, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/29017929/inappropriate-sinus-tachycardia-symptom-and-heart-rate-reduction-with-ivabradine-pooled-analysis-of-prospective-studies
#15
Sunil T Mathew, Sunny S Po, Udho Thadani
BACKGROUND: Inappropriate sinus tachycardia (IST) is debilitating despite available treatment. Off-label use of ivabradine for IST prompted this systematic analysis of existing data quality and sample size estimates for adequately powered studies. OBJECTIVE: To determine clinical efficacy of ivabradine in IST from pooled prospective studies. METHODS: Analysis included ivabradine studies, for IST subjects without structural heart disease and follow-up of > 2 weeks...
October 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29017777/predictive-value-of-inter-atrial-block-for-new-onset-or-recurrent-atrial-fibrillation-a-systematic-review-and-meta-analysis
#16
Gary Tse, Cheuk Wai Wong, Mengqi Gong, Wing Tak Wong, George Bazoukis, Sunny Hei Wong, Guangping Li, William K K Wu, Lap Ah Tse, Konstantinos Lampropoulos, Yunlong Xia, Tong Liu, Adrian Baranchuk
BACKGROUND AND OBJECTIVES: Inter-atrial block (IAB) is characterized by a delay of inter-atrial conduction and is defined electrocardiographically by a P-wave duration (PWD)>120ms. Several studies have implicated IAB in the development of new onset atrial fibrillation (AF), whereas others have reported no significant associations. Moreover, there has been no systematic evaluation of the predictive value of IAB in AF recurrence. Therefore, we conducted a systematic review and meta-analysis to examine whether IAB predicts new onset AF or AF recurrence...
October 3, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29017075/a-simple-dilute-and-shoot-approach-incorporated-with-pentafluorophenyl-pfp-column-based-lc-ms-ms-assay-for-the-simultaneous-determination-of-trimethylamine-n-oxide-and-trimethylamine-in-spot-urine-samples-with-high-throughput
#17
Xiaoguang Sunny Li, Shu Li, Gottfried Kellermann
Determination of trimethylamine N-oxide (TMAO) and trimethylamine (TMA) in biological and environmental samples has drawn great attention recently due to their increasing association with human health and disease. It remains a challenge to simultaneously quantify TMAO and TMA in a simple, fast and cost-effective manner due to pre-analytical and analytical constraints. For the first time, we describe a dilute and shoot approach combined with LC-MS/MS detection for the simultaneous measurement of the analytes in spot urine samples with high throughput...
October 3, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29016645/spontaneous-variability-of-pre-dialysis-concentrations-of-uremic-toxins-over-time-in-stable-hemodialysis-patients
#18
Sunny Eloot, Wim Van Biesen, Sanne Roels, Willem Delrue, Eva Schepers, Annemieke Dhondt, Raymond Vanholder, Griet Glorieux
BACKGROUND AND AIM: Numerous outcome studies and interventional trials in hemodialysis (HD) patients are based on uremic toxin concentrations determined at one single or a limited number of time points. The reliability of these studies however entirely depends on how representative these cross-sectional concentrations are. We therefore investigated the variability of predialysis concentrations of uremic toxins over time. METHODS: Prospectively collected predialysis serum samples of the midweek session of week 0, 1, 2, 3, 4, 8, 12, and 16 were analyzed for a panel of uremic toxins in stable chronic HD patients (N = 18) while maintaining dialyzer type and dialysis mode during the study period...
2017: PloS One
https://www.readbyqxmd.com/read/28993351/haematuria-in-adpkd-not-always-benign-be-aware
#19
Manav Agarwal, Ashok Kumar Sokhal, Manoj Kumar, Sunny Goel
Haematuria in patients with autosomal dominant polycystic kidney disease (ADPKD) is a very common manifestation. The cause of haematuria is often benign with the most common cause being haemorrhage within the renal cyst. But haematuria may also be caused by a coincident malignancy, the diagnosis of which may be missed if not investigated thoroughly. Herein, we present a case of ADPKD who presented to us with haematuria and was later found to have bladder cancer.
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28992139/concentrations-of-representative-uraemic-toxins-in-a-healthy-versus-non-dialysis-chronic-kidney-disease-paediatric-population
#20
Evelien Snauwaert, Wim Van Biesen, Ann Raes, Griet Glorieux, Valerie Van Bogaert, Koen Van Hoeck, Marc Coppens, Sanne Roels, Johan Vande Walle, Sunny Eloot
Background: Chronic kidney disease (CKD) in childhood is poorly explained by routine markers (e.g. urea and creatinine) and is better depicted in adults by other uraemic toxins. This study describes concentrations of representative uraemic toxins in non-dialysis CKD versus healthy children. Methods: In 50 healthy children and 57 children with CKD Stages 1-5 [median estimated glomerular filtration rate 48 (25th-75th percentile 24-71) mL/min/1.73 m 2 ; none on dialysis], serum concentrations of small solutes [symmetric and asymmetric dimethyl-arginine (SDMA and ADMA, respectively)], middle molecules [β2-microglobuline (β2M), complement factor D (CfD)] and protein-bound solutes [ p -cresylglucuronide (pCG), hippuric acid (HA), indole-acetic acid (IAA), indoxyl sulphate (IxS), p -cresyl sulphate (pCS) and 3-carboxy-4-methyl-5-propyl-furanpropionic acid (CMPF)] were measured...
July 24, 2017: Nephrology, Dialysis, Transplantation
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