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Boya Zhang, Yangzhige He, Yanpeng Xu, Fan Mo, Tingwei Mi, Qing Sunny Shen, Chunfeng Li, Yali Li, Jing Liu, Yihui Wu, Guilai Chen, Wenliang Zhu, Chengfeng Qin, Baoyang Hu, Guomin Zhou
Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) poses a serious threat to the world's public health yet without a cure. Certain JEV-infected neural cells express a subset of previously identified intrinsic antiviral interferon stimulated genes (ISGs), indicating brain cells retain autonomous antiviral immunity. However, whether this happens in composited brain remains unclear. Human pluripotent stem cell (hPSC)-derived organoids can model disorders caused by human endemic pathogens such as Zika virus, which may potentially address this question and facilitate the discovery of a cure for JE...
June 18, 2018: Cell Death & Disease
Steven Davey, Jamin Halberstadt, Elliot Bell, Sunny Collings
BACKGROUND: Alexithymia is a problem of emotion regulation and for this reason alone may relate to suicidality. This article investigates the evidence for a direct relationship. It explores the possibility of an additional role for interoception in future research. METHODS: A scoping review of peer-reviewed journal articles examining alexithymia and suicidality was undertaken, followed by a critical assessment of the overall state of the evidence base in relation to interoception...
June 7, 2018: Journal of Affective Disorders
Carsten Schroeder, Jane M Chung, Judith A Mackall, Ivan T Cakulev, Aaron Patel, Sunny J Patel, Brian D Hoit, Jayakumar Sahadevan
OBJECTIVE: The aim of the study was to study the feasibility, safety, and efficacy of transesophageal echocardiography-guided intraoperative left ventricular lead placement via a video-assisted thoracoscopic surgery approach in patients with failed conventional biventricular pacing. METHODS: Twelve patients who could not have the left ventricular lead placed conventionally underwent epicardial left ventricular lead placement by video-assisted thoracoscopic surgery...
June 14, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
John M Hollingsworth, Brahmajee K Nallamothu, Phyllis Yan, Sarah Ward, Sunny Lin, Carrie H Colla, Valerie A Lewis, John Z Ayanian, Brent K Hollenbeck, Andrew M Ryan
BACKGROUND: Because specialty care accounts for half of Medicare expenditures, improving its value is critical to the success of Medicare accountable care organizations (ACOs) in curbing spending growth. However, whether ACOs have reduced low-value specialty care without compromising use of high-value services remains unknown. METHODS AND RESULTS: Using national Medicare data, we identified 2 cohorts: beneficiaries for whom the value of coronary revascularization is lower (those with ischemic heart disease without angina, congestive heart failure, or recent admission for acute myocardial infarction) and beneficiaries for whom its value is higher (those with recent acute myocardial infarction admission)...
June 2018: Circulation. Cardiovascular Quality and Outcomes
Emeka Emmanuel Okoro, Adewale Dosunmu, Sunny E Iyuke
The focus of this research was to present a data article for analyzing the cost of displacing a drilling fluid during the drilling operation. The cost of conventional Spud, KCl and Pseudo Oil base (POBM) muds used in drilling oil and gas wells are compared with that of a Reversible Invert Emulsion Mud. The cost analysis is limited to three sections for optimum and effective Comparison. To optimize drilling operations, it is important that we specify the yardstick by which drilling performance is measured. The most relevant yardstick is the cost per foot drilled...
August 2018: Data in Brief
Samarth Agarwal, Sunny Goel, Satyanarayan Sankhwar, Gaurav Garg
No abstract text is available yet for this article.
June 13, 2018: BMJ Case Reports
Nansi S Boghossian, Winston Koo, Aiyi Liu, Sunni L Mumford, Michael Y Tsai, Edwina H Yeung
BACKGROUND/OBJECTIVES: Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry and body composition as assessed by dual energy X-ray absorptiometry (DXA). SUBJECTS/METHODS: Three longitudinal pregnancy samples from the Memphis site of the Calcium for Preeclampsia Prevention trial (1992-1995) were used...
June 12, 2018: European Journal of Clinical Nutrition
Ka H C Li, Mei Dong, Mengqi Gong, George Bazoukis, Ishan Lakhani, Yan Y Ting, Sunny H Wong, Guangping Li, William K K Wu, Vassilios S Vassiliou, Martin C S Wong, Konstantinos Letsas, Yimei Du, Victoria Laxton, Bryan P Yan, Yat S Chan, Yunlong Xia, Tong Liu, Gary Tse
Background and Objectives: Atrial fibrillation is a common abnormal cardiac rhythm caused by disorganized electrical impulses. AF which is refractory to antiarrhythmic management is often treated with catheter ablation. Recently a novel ablation system (nMARQ) was introduced for PV isolation. However, there has not been a systematic review of its efficacy or safety compared to traditional ablation techniques. Therefore, we conducted this meta-analysis on the nMARQ ablation system. Methods: PubMed and EMBASE were searched up until 1st of September 2017 for articles on nMARQ...
2018: Frontiers in Physiology
Noam Stern-Ginossar, Sunnie R Thompson, Michael B Mathews, Ian Mohr
As obligate intracellular parasites, virus reproduction requires host cell functions. Despite variations in genome size and configuration, nucleic acid composition, and their repertoire of encoded functions, all viruses remain unconditionally dependent on the protein synthesis machinery resident within their cellular hosts to translate viral messenger RNAs (mRNAs). A complex signaling network responsive to physiological stress, including infection, regulates host translation factors and ribosome availability...
June 11, 2018: Cold Spring Harbor Perspectives in Biology
Sunni L Mumford, Edwina H Yeung
No abstract text is available yet for this article.
June 8, 2018: Fertility and Sterility
Wuhong Pei, Lisha Xu, Sunny C Huang, Kade Pettie, Jennifer Idol, Alberto Rissone, Erin Jimenez, Jason W Sinclair, Claire Slevin, Gaurav K Varshney, MaryPat Jones, Blake Carrington, Kevin Bishop, Haigen Huang, Raman Sood, Shuo Lin, Shawn M Burgess
Regenerative medicine holds great promise for both degenerative diseases and traumatic tissue injury which represent significant challenges to the health care system. Hearing loss, which affects hundreds of millions of people worldwide, is caused primarily by a permanent loss of the mechanosensory receptors of the inner ear known as hair cells. This failure to regenerate hair cells after loss is limited to mammals, while all other non-mammalian vertebrates tested were able to completely regenerate these mechanosensory receptors after injury...
2018: NPJ Regenerative Medicine
Sunni L Mumford, Rebecca A Garbose, Keewan Kim, Kerri Kissell, Daniel L Kuhr, Ukpebo R Omosigho, Neil J Perkins, Noya Galai, Robert M Silver, Lindsey A Sjaarda, Torie C Plowden, Enrique F Schisterman
BACKGROUND: Vitamin D deficiency during pregnancy is associated with adverse pregnancy outcomes, although the association between preconception vitamin D concentrations and livebirth is unknown. We aimed to assess the association between preconception vitamin D and pregnancy outcomes among women with proven fecundity. METHODS: We did a secondary analysis of a prospective cohort from the block-randomised, double-blind, placebo-controlled EAGeR trial. Women aged 18-40 years with one to two previous pregnancy losses were recruited from June 15, 2007, to July 15, 2011, at four clinical sites in the USA and followed up for up to six menstrual cycles while attempting pregnancy and throughout pregnancy if they conceived...
May 30, 2018: Lancet Diabetes & Endocrinology
Brian J Lipworth, Sunny Jabbal
Impulse oscillometry (IOS) is the most commonly used type of forced oscillation technique in clinical practice, although relatively little is known about its application in COPD. Resistance at 20 Hz (R20) is unrelated to COPD severity and does not improve with bronchodilatation or bronchoconstriction, inferring a lack of large airway involvement in COPD. Peripheral airway resistance expressed as frequency dependent heterogeneity between 5 Hz and 20 Hz (R5-R20), and peripheral airway compliance as area under the reactance curve (AX), are both closely related to COPD severity and exacerbations...
June 2018: Respiratory Medicine
Qing Tang, Swei Sunny Hann
Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to be determined...
May 24, 2018: Cellular Physiology and Biochemistry
SongTao Xiang, PeiLiang Zou, JingJing Wu, Fang Zheng, Qing Tang, Jianfu Zhou, Swei Sunny Hann
BACKGROUND/AIMS: Polyphyllin I (PPI), one of the steroidal saponins in Paris polyphylla, reportedly exhibits antitumor effects. However, the detailed mechanism underlying PPI, particularly in enhancing the effect of the androgen receptor inhibitor enzalutamide in controlling castration-resistant prostate cancer (CRPC) has not been explored. METHODS: Cell viability and cell cycle distribution were measured using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, respectively...
May 22, 2018: Cellular Physiology and Biochemistry
Nicolas W Shammas, Ryan Kelly, Jon Lemke, Ram Niwas, Sarah Castro, Christine Beuthin, Jackie Carlson, Marti Cox, Gail A Shammas, Terri DeClerck, Kathy Lenaghan, Sunny Arikat, Marcia Erickson
Background: Hospital inpatient readmissions for patients admitted initially with the primary diagnosis of heart failure (HF) can be as high as 20-25% within 30 days of discharge. This, however, does not include admissions for observations or emergency department (ED) visits within the same time frame and does not show a time-dependent hospital encounter following discharge after an index admission. We present data on time-dependent hospital encounter of HF patients discharged after an index admission for a primary diagnosis of HF...
2018: Cardiology Research and Practice
Sunny B Bhakta, A Carmine Colavecchia, William Coffey, David R Curlee, Kevin W Garey
PURPOSE: The purpose of this study was to quantify the impact of robotic technology on efficiency, accuracy, and cost in a satellite oncology pharmacy. METHODS: A 33-week quasi-experimental study was conducted at an academic, quaternary care institution with 1,119 licensed beds from June 2016 to February 2017 to evaluate the turnaround time (TAT) for preparations compounded by automated robotic compounding technology (ARCT) versus historical procedures. Secondary endpoints included mean preparation time and percentage of doses with a TAT of <30 minutes before and after the implementation of ARCT and were evaluated using time-segmented regression analysis...
June 1, 2018: American Journal of Health-system Pharmacy: AJHP
Anant Ramaswamy, Sunny Jandyal, Vikas Ostwal, Reena Engineer, Shirley Lewis, Subhadeep Bose, Nikhil Pande, Shailesh V Shrikhande
BACKGROUND: Outcomes and survival of truly unresectable locally advanced pancreatic cancers (LAPC) is often reported along with borderline resectable pancreatic cancers especially from a real world cohort. METHODS: The audit of LAPC patients, diagnosed based on the NCCN criteria between February 2013 and January 2016 was used to identify patients starting and continuing treatment in our institution. Practice patterns, outcomes and prognostic factors for overall survival were evaluated...
July 2017: Indian Journal of Cancer
Griffith A Bell, Rajeshwari Sundaram, Sunni L Mumford, Hyojun Park, Miranda Broadney, James L Mills, Erin M Bell, Edwina H Yeung
BACKGROUND: Polycystic ovarian syndrome (PCOS) is the most common cause of female infertility and is associated with higher levels of circulating androgens. Exposure to higher levels of androgens in utero may be a risk factor for obesity among children of women with PCOS. METHODS: We examined whether maternal PCOS was associated with differences in offspring growth and obesity in the Upstate KIDS study, a prospective cohort study of infants born in New York State (excluding New York City) oversampled for fertility treatments and multiple births...
May 22, 2018: Journal of Epidemiology and Community Health
Jodie Birch, Syba S Sunny, Katy L M Hester, Gareth Parry, F Kate Gould, John H Dark, Stephen C Clark, Gerard Meachery, James Lordan, Andrew J Fisher, Paul A Corris, Anthony De Soyza
BACKGROUND: Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here. METHODS: A retrospective review of case notes and transplantation databases was conducted for patients that had underwent lung transplantation for bronchiectasis at the Freeman Hospital between 1990 and 2013. RESULTS: Fourty two BR patients underwent lung transplantation, the majority (39) having bilateral sequential lung transplantation...
May 22, 2018: BMC Pulmonary Medicine
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