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antibiotics versus appendicectomy

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https://www.readbyqxmd.com/read/28818844/conservative-treatment-versus-surgery-for-uncomplicated-appendicitis-in-children-a-systematic-review-and-meta-analysis
#1
Ulf Kessler, Selim Mosbahi, Benedict Walker, Eva M Hau, Michael Cotton, Barbara Peiry, Steffen Berger, Bernhard Egger
OBJECTIVES: To compare conservative treatment with index admission appendicectomy in children with acute uncomplicated appendicitis. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Medline, Embase and the Cochrane Library (CENTRAL) from 1950 to 18 February 2017. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Studies that assessed both appendicectomy and non-operative management of acute uncomplicated appendicitis in children of less than 18 years of age...
August 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28677879/economic-evaluation-of-antibiotic-therapy-versus-appendicectomy-for-the-treatment-of-uncomplicated-acute-appendicitis-from-the-appac-randomized-clinical-trial
#2
S Sippola, J Grönroos, R Tuominen, H Paajanen, T Rautio, P Nordström, M Aarnio, T Rantanen, S Hurme, P Salminen
BACKGROUND: An increasing amount of evidence supports antibiotic therapy for treating uncomplicated acute appendicitis. The objective of this study was to compare the costs of antibiotics alone versus appendicectomy in treating uncomplicated acute appendicitis within the randomized controlled APPAC (APPendicitis ACuta) trial. METHODS: The APPAC multicentre, non-inferiority RCT was conducted on patients with CT-confirmed uncomplicated acute appendicitis. Patients were assigned randomly to appendicectomy or antibiotic treatment...
September 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28574593/early-versus-delayed-appendicectomy-for-appendiceal-phlegmon-or-abscess
#3
REVIEW
Yao Cheng, Xianze Xiong, Jiong Lu, Sijia Wu, Rongxing Zhou, Nansheng Cheng
BACKGROUND: Appendiceal phlegmon and abscess account for 2% to 10% of acute appendicitis. People with appendiceal phlegmon or abscess usually need an appendicectomy to relieve their symptoms and avoid complications. The timing of appendicectomy for appendiceal phlegmon or abscess is controversial. OBJECTIVES: To assess the effects of early versus delayed appendicectomy for appendiceal phlegmon or abscess, in terms of overall morbidity and mortality. SEARCH METHODS: We searched the Cochrane Library (CENTRAL; 2016, Issue 7), MEDLINE Ovid (1950 to 23 August 2016), Embase Ovid (1974 to 23 August 2016), Science Citation Index Expanded (1900 to 23 August 2016), and the Chinese Biomedical Literature Database (CBM) (1978 to 23 August 2016)...
June 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28112705/antibiotics-alone-for-uncomplicated-acute-appendicitis-in-high-operative-risk-adult-patients-analytical-review-of-rcts-and-proposal-of-evidence-based-treatment-decision
#4
Hariscine Keng Abongwa, G Cervellin, A Tarasconi, G Perrone, G Baiocchi, N Portolani, F Catena
BACKGROUND: Clinical trials have so far shown controversial results as regards the standard of care for treating uncomplicated acute appendicitis (uC-AA). High operational risk adult patients (HORAP) could represent selected patients where primary antibiotic conservative therapy (pACT or A) could be indicated. METHODS: We carried a comprehensive search of the PubMed searching engine in the English language scientific literature from 1995 to 2015, using medical subject headings "antibiotics", "uncomplicated appendicitis", "appendicectomy", "conservative treatment", "surgery" and "randomized clinical trial"...
January 16, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/27199000/antibiotics-versus-appendicectomy-for-the-treatment-of-uncomplicated-acute-appendicitis-an-updated-meta-analysis-of-randomised-controlled-trials
#5
Katie E Rollins, Krishna K Varadhan, Keith R Neal, Dileep N Lobo
BACKGROUND: Uncomplicated acute appendicitis has been managed traditionally by early appendicectomy. However, recently, there has been increasing interest in the potential for primary treatment with antibiotics, with studies finding this to be associated with fewer complications than appendicectomy. The aim of this study was to compare outcomes of antibiotic therapy with appendicectomy for uncomplicated acute appendicitis. METHOD: This meta-analysis of randomised controlled trials included adult patients presenting with uncomplicated acute appendicitis treated with antibiotics or appendicectomy...
October 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/26990957/meta-analysis-of-antibiotics-versus-appendicectomy-for-non-perforated-acute-appendicitis
#6
REVIEW
V Sallinen, E A Akl, J J You, A Agarwal, S Shoucair, P O Vandvik, T Agoritsas, D Heels-Ansdell, G H Guyatt, K A O Tikkinen
BACKGROUND: For more than a century, appendicectomy has been the treatment of choice for appendicitis. Recent trials have challenged this view. This study assessed the benefits and harms of antibiotic therapy compared with appendicectomy in patients with non-perforated appendicitis. METHODS: A comprehensive search was conducted for randomized trials comparing antibiotic therapy with appendicectomy in patients with non-perforated appendicitis. Key outcomes were analysed using random-effects meta-analysis, and the quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach...
May 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/25282456/-comparison-of-two-protocols-of-prophylactic-antibiotic-therapy-in-childhood-appendectomy
#7
COMPARATIVE STUDY
C Bechis, F Michel, T Merrot, P Nicoleta, A Lando, M Leone, C Martin
OBJECTIVE: Antibiotic administration during acute appendicitis in children continues to be debated. The purpose of this study was to compare efficacy of two prophylactic antibiotic treatment guidelines in acute appendicitis and peritonitis in children. MATERIEL AND METHODS: The infectious complication rate after appendicectomy was compared during two distinct periods (before/after study). During the first period, the guidelines for antibiotic administration were based on ticarcillin-clavulanic acid...
November 2014: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/24940408/meta-analysis-of-the-therapeutic-effects-of-antibiotic-versus-appendicectomy-for-the-treatment-of-acute-appendicitis
#8
Zhi-Hua Liu, Chao Li, Xing-Wei Zhang, Liang Kang, Jian-Ping Wang
Appendicectomy has been the gold standard treatment of acute appendicitis for more than a century, while nonoperative therapies, including antibiotics, have acquired increased interest in recent years. The present meta-analysis aimed to compare the therapeutic effects of antibiotics versus appendicectomy for the treatment of acute appendicitis. Medline, Embase and The Cochrane Library databases were searched. Prospective randomized controlled trials that compared antibiotic treatment with surgery were included...
May 2014: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/24714099/antibiotics-versus-appendicectomy-in-the-management-of-acute-appendicitis-an-ongoing-debate
#9
Gerard J Fitzmaurice, Emanuel Epanomeritakis
No abstract text is available yet for this article.
2012: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/22491789/safety-and-efficacy-of-antibiotics-compared-with-appendicectomy-for-treatment-of-uncomplicated-acute-appendicitis-meta-analysis-of-randomised-controlled-trials
#10
COMPARATIVE STUDY
Krishna K Varadhan, Keith R Neal, Dileep N Lobo
OBJECTIVE: To compare the safety and efficacy of antibiotic treatment versus appendicectomy for the primary treatment of uncomplicated acute appendicitis. DESIGN: Meta-analysis of randomised controlled trials. POPULATION: Randomised controlled trials of adult patients presenting with uncomplicated acute appendicitis, diagnosed by haematological and radiological investigations. INTERVENTIONS: Antibiotic treatment versus appendicectomy...
April 5, 2012: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/21550483/amoxicillin-plus-clavulanic-acid-versus-appendicectomy-for-treatment-of-acute-uncomplicated-appendicitis-an-open-label-non-inferiority-randomised-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Corinne Vons, Caroline Barry, Sophie Maitre, Karine Pautrat, Mahaut Leconte, Bruno Costaglioli, Mehdi Karoui, Arnaud Alves, Bertrand Dousset, Patrice Valleur, Bruno Falissard, Dominique Franco
BACKGROUND: Researchers have suggested that antibiotics could cure acute appendicitis. We assessed the efficacy of amoxicillin plus clavulanic acid by comparison with emergency appendicectomy for treatment of patients with uncomplicated acute appendicitis. METHODS: In this open-label, non-inferiority, randomised trial, adult patients (aged 18-68 years) with uncomplicated acute appendicitis, as assessed by CT scan, were enrolled at six university hospitals in France...
May 7, 2011: Lancet
https://www.readbyqxmd.com/read/19358184/randomized-clinical-trial-of-antibiotic-therapy-versus-appendicectomy-as-primary-treatment-of-acute-appendicitis-in-unselected-patients
#12
RANDOMIZED CONTROLLED TRIAL
J Hansson, U Körner, A Khorram-Manesh, A Solberg, K Lundholm
BACKGROUND: A trial in selected men suggested that antibiotic therapy could be an alternative to appendicectomy in appendicitis. This study aimed to evaluate antibiotic therapy in unselected men and women with acute appendicitis. METHODS: Consecutive patients were allocated to study (antibiotics) or control (surgery) groups according to date of birth. Study patients received intravenous antibiotics for 24 h and continued at home with oral antibiotics for 10 days...
May 2009: British Journal of Surgery
https://www.readbyqxmd.com/read/16703441/open-versus-laparoscopic-appendicectomy-a-critical-review
#13
REVIEW
M Kapischke, A Caliebe, J Tepel, T Schulz, J Hedderich
BACKGROUND: The benefit of laparoscopic appendicectomy remains unclear. We have analysed available randomised studies comparing laparoscopic and open appendicectomy regarding their clinical pitfalls and statistical relevance. METHODS: Thirty eight studies were analysed in terms of the following aspects: A. clinical problems (e.g., expertise of the surgeons, pre- and postoperative antibiotic treatment, definition of complications, blinding of outcomes) and B. statistical problems (e...
July 2006: Surgical Endoscopy
https://www.readbyqxmd.com/read/16034862/antibiotics-versus-placebo-for-prevention-of-postoperative-infection-after-appendicectomy
#14
REVIEW
B R Andersen, F L Kallehave, H K Andersen
BACKGROUND: Appendicitis is the most common cause of acute abdominal pain requiring surgical intervention. The cause of appendicitis is unclear and the mechanism of pathogenesis continues to be debated. Despite improved asepsis and surgical techniques, postoperative complications, such as wound infection and intraabdominal abscess, still account for a significant morbidity. Several studies implicate that postoperative infections are reduced by administration of antimicrobial regimes. OBJECTIVES: This review evaluated the use of antibiotics compared to placebo or no treatment in patients undergoing appendectomy...
July 20, 2005: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/12804408/antibiotics-versus-placebo-for-prevention-of-postoperative-infection-after-appendicectomy
#15
REVIEW
B R Andersen, F L Kallehave, H K Andersen
BACKGROUND: Appendicitis is the most common cause of acute abdominal pain requiring surgical intervention. The cause of appendicitis is unclear and the mechanism of pathogenesis continues to be debated. Despite improved asepsis and surgical techniques, postoperative complications, such as wound infection and intraabdominal abscess, still account for a significant morbidity. Several studies implicate that postoperative infections are reduced by administration of antimicrobial regimes. OBJECTIVES: The objective of this review is to evaluate the use of antibiotics with placebo or no treatment in patients undergoing appendectomy...
2003: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/12525844/-comparative-evaluation-of-the-surgical-treatment-of-acute-appendicitis-open-appendicetomy-versus-laparoscopic-appendicectomy-in-the-national-hospital-hospital-carlos-a-seguin-e-essalud
#16
COMPARATIVE STUDY
Edgar Marcial Rivera Díaz
STATE OF THE PROBLEM: To establish the advantages and disadvantages of open appendicectomy versus laparoscopic appendicectomy in the surgical treatment of acute appendicitis in the National Hospital Carlos Alberto Seguin Escobedo. OBJECTIVES/AIMS: Comparative evaluation of open appendicectomy versus laparoscopic appendicectomy in their grouped in: a) Characters/Features.- Age, sex, occupation, time of disease, symptoms and signs, laboratory investigations, pre and post operative diagnoses, pre and post operative antibiotic therapy and time of anesthesia, b) Impact of surgical techniques in: preoperative time, operative time, operative accidents, stay in hospital and postoperative complications, and c) Evaluation of the benefits through comparative costs of both techniques...
October 2002: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/11405988/antibiotics-versus-placebo-for-prevention-of-postoperative-infection-after-appendicectomy
#17
REVIEW
B R Andersen, F L Kallehave, H K Andersen
BACKGROUND: Appendicitis is the most common cause of acute abdominal pain requiring surgical intervention. The cause of appendicitis is unclear and the mechanism of pathogenesis continues to be debated. Despite improved asepsis and surgical techniques, postoperative complications, such as wound infection and intraabdominal abscess, still account for a significant morbidity. Several studies implicate that postoperative infections are reduced by administration of antimicrobial regimes. OBJECTIVES: The objective of this review is to compare the use of antibiotics with placebo or no treatment in patients undergoing appendectomy...
2001: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/10700762/association-between-streptococcus-milleri-and-abscess-formation-after-appendicitis
#18
R H Hardwick, A Taylor, M H Thompson, E Jones, A M Roe
Abscesses after appendicitis occur in some patients despite timely surgery and antibiotics. The Streptococcus milleri group of bacteria are commonly associated with gastrointestinal abscesses. This study investigated the relationship between S. milleri and abscess formation after appendicectomy a total of 301 patients (172 males, 129 females, median age 22 years) with appendicitis were identified retrospectively from the hospital PAS computer system who had an appendicectomy and peritoneal bacteriology swabs taken...
January 2000: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/9420396/comparative-evaluation-of-conservative-management-versus-early-surgical-intervention-in-appendicular-mass-a-clinical-study
#19
RANDOMIZED CONTROLLED TRIAL
P Garg, B K Dass, A R Bansal, N Chitkara
The management of appendicular mass seems to be taking turn with the availability of better antibiotics, care and anaesthesia. Quite a few workers turned to the other extreme of traditional conservative approach and reported acceptable results with immediate intervention during phlegmonous stage. But practically, surgeons still continue to adopt the same old regime. To alleviate this fear and circumvent the disadvantages of immediate intervention a midpath regime called early appendicectomy has been clinically evaluated...
June 1997: Journal of the Indian Medical Association
https://www.readbyqxmd.com/read/8313090/laparoscopic-versus-open-appendicectomy-a-prospective-assessment
#20
J A Lujan Mompean, R Robles Campos, P Parrilla Paricio, V Soria Aledo, J Garcia Ayllon
A prospective study of 200 consecutive patients with suspected acute appendicitis was performed to compare open and laparoscopic appendicectomy. Formal randomization was precluded by instrument availability. Some 100 patients underwent laparoscopic appendicectomy (conversion to laparotomy was carried out in five) and 100 had conventional surgery. The groups were similar in sex ratio, age, degree of appendiceal inflammation and antibiotic treatment. The mean duration of open appendicectomy was 46 min and of the laparoscopic procedure 51 min (P not significant)...
January 1994: British Journal of Surgery
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