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https://www.readbyqxmd.com/read/28944936/smoking-cessation-in-workplace-settings-quit-rates-and-determinants-in-a-group-behaviour-therapy-programme
#1
Yann Hausherr, Carlos Quinto, Leticia Grize, Christian Schindler, Nicole Probst-Hensch
INTRODUCTION: To capitalise on the opportunities that the smoking ban legislation in Switzerland offers for the prevention of tobacco-related diseases, a smoking cessation programme in a workplace setting was developed and implemented in companies across the language and cultural regions of Switzerland. Our goal was to identify factors associated with relapse into smoking that may be overcome during training sessions or that should be considered for the optimisation of future interventions...
September 25, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28944611/gene-therapy-with-the-trf1-telomere-gene-rescues-decreased-trf1-levels-with-aging-and-prolongs-mouse-health-span
#2
Aksinya Derevyanko, Kurt Whittemore, Ralph P Schneider, Verónica Jiménez, Fàtima Bosch, Maria A Blasco
The shelterin complex protects telomeres by preventing them from being degraded and recognized as double-strand DNA breaks. TRF1 is an essential component of shelterin, with important roles in telomere protection and telomere replication. We previously showed that TRF1 deficiency in the context of different mouse tissues leads to loss of tissue homeostasis owing to impaired stem cell function. Here, we show that TRF1 levels decrease during organismal aging both in mice and in humans. We further show that increasing TRF1 expression in both adult (1-year-old) and old (2-year-old) mice using gene therapy can delay age-associated pathologies...
September 24, 2017: Aging Cell
https://www.readbyqxmd.com/read/28944527/psychophysiological-changes-during-pure-vs-guided-mirror-exposure-therapies-in-women-with-high-body-dissatisfaction-what-are-they-learning-about-their-bodies
#3
Sandra Díaz-Ferrer, Sonia Rodríguez-Ruiz, Blanca Ortega-Roldán, José Luis Mata-Martín, M Carmen Fernández-Santaella
This study aimed to examine the psychophysiological changes resulting from two mirror exposure treatments that are effective at reducing body dissatisfaction. Thirty-five university women with body dissatisfaction and subclinical eating disorders were randomly assigned to one of two groups: pure (n = 17) or guided exposure (n = 18). The participants received six sessions of treatment. Their thoughts, feelings and avoidance behaviours were assessed after each session. Their subjective discomfort, heart rate and skin conductance were assessed within the sessions...
September 24, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28943232/daily-opioid-use-fluctuates-as-a-function-of-pain-catastrophizing-and-affect-in-patients-with-sickle-cell-disease-an-electronic-daily-diary-analysis
#4
Patrick H Finan, C Patrick Carroll, Gyasi Moscou-Jackson, Marc O Martel, Claudia M Campbell, Alex Pressman, Joshua M Smyth, Jean-Michel Tremblay, Sophie M Lanzkron, Jennifer A Haythornthwaite
Chronic opioid therapy is a common treatment regimen for patients with sickle cell disease (SCD), a chronically painful recessive hemoglobinopathy. The collective risk profile of chronic opioid therapy necessitates an understanding of which pain-related factors, such as affect and pain catastrophizing, are associated with the ebbs and flows of opioid use in daily life, a topic that has received very little attention among patients with any type of chronically painful condition, including SCD. We therefore investigated the variability of day-to-day patterns of short and long-acting opioid use and their associations with pain and pain-related cognitive and affective processes in daily life among patients with SCD using a nightly electronic diary (N = 45)...
September 21, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28942806/comparison-of-stepped-care-delivery-against%C3%A2-a%C3%A2-single-empirically-validated-cognitive-behavioral-therapy-program-for-youth-with-anxiety-a-randomized-clinical-trial
#5
Ronald M Rapee, Heidi J Lyneham, Viviana Wuthrich, Mary Lou Chatterton, Jennifer L Hudson, Maria Kangas, Cathrine Mihalopoulos
OBJECTIVE: Stepped care is embraced as an ideal model of service delivery but is minimally evaluated. The aim of this study was to evaluate the efficacy of cognitive-behavioral therapy (CBT) for child anxiety delivered via a stepped-care framework compared against a single, empirically validated program. METHOD: A total of 281 youth with anxiety disorders (6-17 years of age) were randomly allocated to receive either empirically validated treatment or stepped care involving the following: (1) low intensity; (2) standard CBT; and (3) individually tailored treatment...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28942803/systematic-review-of-universal-resilience-focused-interventions-targeting-child-and-adolescent-mental-health-in-the-school-setting
#6
REVIEW
Julia Dray, Jenny Bowman, Elizabeth Campbell, Megan Freund, Luke Wolfenden, Rebecca K Hodder, Kathleen McElwaine, Danika Tremain, Kate Bartlem, Jacqueline Bailey, Tameka Small, Kerrin Palazzi, Christopher Oldmeadow, John Wiggers
OBJECTIVE: To examine the effect of universal, school-based, resilience-focused interventions on mental health problems in children and adolescents. METHOD: Eligible studies were randomized controlled trials (RCTs) of universal, school-based interventions that included strategies to strengthen a minimum of 3 internal resilience protective factors, and included an outcome measure of mental health problems in children and adolescents aged 5 to 18 years. Six databases were searched from 1995 to 2015...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28942748/nutritional-psychiatry-the-present-state-of-the-evidence
#7
Wolfgang Marx, Genevieve Moseley, Michael Berk, Felice Jacka
Mental illness, including depression, anxiety and bipolar disorder, accounts for a significant proportion of global disability and poses a substantial social, economic and heath burden. Treatment is presently dominated by pharmacotherapy, such as antidepressants, and psychotherapy, such as cognitive behavioural therapy; however, such treatments avert less than half of the disease burden, suggesting that additional strategies are needed to prevent and treat mental disorders. There are now consistent mechanistic, observational and interventional data to suggest diet quality may be a modifiable risk factor for mental illness...
September 25, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28942477/cognitive-performance-in-mid-stage-parkinson-s-disease-functional-connectivity-under-chronic-antiparkinson-treatment
#8
Roxana Vancea, Kristina Simonyan, Maria Petracca, Miroslaw Brys, Alessandro Di Rocco, Maria Felice Ghilardi, Matilde Inglese
Cognitive impairment in Parkinson's disease (PD) is related to the reorganization of brain topology. Although drug challenge studies have proven how levodopa treatment can modulate functional connectivity in brain circuits, the role of chronic dopaminergic therapy on cognitive status and functional connectivity has never been investigated. We sought to characterize brain functional topology in mid-stage PD patients under chronic antiparkinson treatment and explore the presence of correlation between reorganization of brain architecture and specific cognitive deficits...
September 23, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28942450/cognitive-function-and-prognosis-of-multimodal-neuroimage-guided-thrombectomy-on-mild-to-moderate-anterior-circulation-infarction-patients-with-broadened-therapeutic-window-a-prospective-study
#9
Guodong Xu, Xiaoli Dong, Xiaoli Niu, Guimin Zheng, Hebo Wang, Fan Zhang, Litao Li, Peiyuan Lv
BACKGROUND AND OBJECTIVES: Endovascular mechanical thrombectomy is an important approach for acute ischemic stroke (AIS) treatment. Multimodal neuroimaging methods ideally provide the exact localization, extent, and metabolic activity of target tissues. Post-stroke cognitive impairment has recently been realized to be another major concern except for neurological function impairment. The aim of our study was to carry out a prospective study to compare neurological and cognitive functions after thrombectomy in mild to moderate anterior circulation infarction patients selected by multimodal neuroimaging...
September 22, 2017: European Neurology
https://www.readbyqxmd.com/read/28942056/children-s-resilience-and-trauma-specific-cognitive-behavioral-therapy-comparing-resilience-as-an-outcome-a-trait-and-a-process
#10
Kaitlin Happer, Elissa J Brown, Komal Sharma-Patel
Resilience, which is associated with relatively positive outcomes following negative life experiences, is an important research target in the field of child maltreatment (Luthar et al., 2000). The extant literature contains multiple conceptualizations of resilience, which hinders development in research and clinical utility. Three models emerge from the literature: resilience as an immediate outcome (i.e., behavioral or symptom response), resilience as a trait, and resilience as a dynamic process. The current study compared these models in youth undergoing trauma-specific cognitive behavioral therapy...
September 20, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28941113/the-efficacy-of-smartphone-based-mental-health-interventions-for-depressive-symptoms-a-meta-analysis-of-randomized-controlled-trials
#11
Joseph Firth, John Torous, Jennifer Nicholas, Rebekah Carney, Abhishek Pratap, Simon Rosenbaum, Jerome Sarris
The rapid advances and adoption of smartphone technology presents a novel opportunity for delivering mental health interventions on a population scale. Despite multi-sector investment along with wide-scale advertising and availability to the general population, the evidence supporting the use of smartphone apps in the treatment of depression has not been empirically evaluated. Thus, we conducted the first meta-analysis of smartphone apps for depressive symptoms. An electronic database search in May 2017 identified 18 eligible randomized controlled trials of 22 smartphone apps, with outcome data from 3,414 participants...
October 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28941098/comparing-three-year-extension-of-early-intervention-service-to-regular-care-following-two-years-of-early-intervention-service-in-first-episode-psychosis-a-randomized-single-blind-clinical-trial
#12
Ashok Malla, Ridha Joober, Srividya Iyer, Ross Norman, Norbert Schmitz, Thomas Brown, Danyael Lutgens, Eric Jarvis, Howard C Margolese, Nicola Casacalenda, Amal Abdel-Baki, Eric Latimer, Sally Mustafa, Sherezad Abadi
This study aimed to determine if, following two years of early intervention service for first-episode psychosis, three-year extension of that service was superior to three years of regular care. We conducted a randomized single blind clinical trial using an urn randomization balanced for gender and substance abuse. Participants were recruited from early intervention service clinics in Montreal. Patients (N=220), 18-35 years old, were randomized to an extension of early intervention service (EEIS; N=110) or to regular care (N=110)...
October 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28941093/staging-in-bipolar-disorder-from-theoretical-framework-to-clinical-utility
#13
Michael Berk, Robert Post, Aswin Ratheesh, Emma Gliddon, Ajeet Singh, Eduard Vieta, Andre F Carvalho, Melanie M Ashton, Lesley Berk, Susan M Cotton, Patrick D McGorry, Brisa S Fernandes, Lakshmi N Yatham, Seetal Dodd
Illness staging is widely utilized in several medical disciplines to help predict course or prognosis, and optimize treatment. Staging models in psychiatry in general, and bipolar disorder in particular, depend on the premise that psychopathology moves along a predictable path: an at-risk or latency stage, a prodrome progressing to a first clinical threshold episode, and one or more recurrences with the potential to revert or progress to late or end-stage manifestations. The utility and validity of a staging model for bipolar disorder depend on its linking to clinical outcome, treatment response and neurobiological measures...
October 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28941087/the-third-wave-of-cognitive-behavioral-therapy-and-the-rise-of-process-based-care
#14
EDITORIAL
Steven C Hayes, Stefan G Hofmann
No abstract text is available yet for this article.
October 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28940630/synthesis-molecular-modeling-and-evaluation-of-novel-sulfonylhydrazones-as-acetylcholinesterase-inhibitors-for-alzheimer-s-disease
#15
Thais B Fernandes, Micael R Cunha, Renata P Sakata, Thalita M Candido, André R Baby, Maurício T Tavares, Euzébio G Barbosa, Wanda P Almeida, Roberto Parise-Filho
Alzheimer's disease (AD) is the most common type of dementia and related to the degeneration of hippocampal cholinergic neurons, which dramatically affects cognitive ability. Acetylcholinesterase (AChE) inhibitors are employed as drugs for AD therapy. Three series of sulfonylhydrazone compounds were designed, and their ability to inhibit AChE was evaluated. Fifteen compounds were synthesized and twelve of them had IC50 values of 0.64-51.09 μM. The preliminary structure-activity relationships indicated that the methylcatechol moiety and arylsulfonyl substituents generated better compounds than both the benzodioxole and alkylsulfonyl chains...
September 22, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28939708/the-decisions-interventions-and-goals-in-implantable-cardioverter-defibrillator-therapy-dignity-pilot-study
#16
Daniel B Kramer, Daniel Habtemariam, Yaw Adjei-Poku, Michelle Samuel, Diane Engorn, Matthew R Reynolds, Susan L Mitchell
BACKGROUND: Implantable cardioverter-defibrillators (ICDs) are commonly implanted in older patients, including those with multiple comorbidities. There are few prospective studies assessing the clinical course and end-of-life circumstances for these patients. METHODS AND RESULTS: We prospectively followed 51 patients with ICDs for up to 18 months to longitudinally assess in terms of (1) advance care planning, (2) health status, (3) healthcare utilization, and (4) end-of-life circumstances through quarterly phone interviews and electronic medical record review...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28939545/protocol-for-co-design-development-and-open-trial-of-a-prototype-game-based-ehealth-intervention-to-treat-anxiety-in-young-people-with-long-term-physical-conditions
#17
Hiran Thabrew, Karolina Stasiak, Sally Merry
BACKGROUND: Approximately 10% to 12% of New Zealand young people (and 21% of Maori young people) have long-term physical conditions and are more likely to develop psychological problems, particularly anxiety and depression. Delayed treatment leads to worse management of physical conditions, school absence, and poorer long-term outcomes. Recently, electronic health (eHealth) interventions have been shown to be as good as face-to-face therapy and biofeedback techniques have been shown to enhance relaxation during the treatment of anxiety...
September 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28939343/effects-of-nurse-led-home-based-exercise-cognitive-behavioral-therapy-on-reducing-cancer-related-fatigue-in-patients-with-ovarian-cancer-during-and-after-chemotherapy-a-randomized-controlled-trial
#18
Qi Zhang, Feng Li, Han Zhang, Xiuli Yu, Yunfeng Cong
BACKGROUND: High levels of fatigue have been documented in ovarian cancer patients. However, increased levels of fatigue are positively associated with a high risk of sleep disturbance and depression. OBJECTIVE: To investigate the feasibility of a nurse-led home-based exercise and cognitive behavioral therapy (E&CBT) for ovarian cancer adults with cancer-related fatigue on outcomes of fatigue, plus other secondary outcomes (sleep disturbance and depression), either during or after completion of primary cancer treatment...
August 24, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28939258/novel-calcium-related-targets-of-insulin-in-hippocampal-neurons
#19
Shaniya Maimaiti, Hilaree N Frazier, Katie L Anderson, Adam O Ghoweri, Lawrence D Brewer, Nada M Porter, Olivier Thibault
Both insulin signaling disruption and Ca(2+) dysregulation are closely related to memory loss during aging and increase the vulnerability to Alzheimer's disease (AD). In hippocampal neurons, aging-related changes in calcium regulatory pathways have been shown to lead to higher intracellular calcium levels and an increase in the Ca(2+)-dependent afterhyperpolarization (AHP), which is associated with cognitive decline. Recent studies suggest that insulin reduces the Ca(2+)-dependent AHP. Given the sensitivity of neurons to insulin and evidence that brain insulin signaling is reduced with age, insulin-mediated alterations in calcium homeostasis may underlie the beneficial actions of insulin in the brain...
September 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28939223/stereotactic-radiosurgery-with-or-without-whole-brain-radiation-therapy-for-limited-brain-metastases-a-secondary-analysis-of-the-north-central-cancer-treatment-group-n0574-alliance-randomized-controlled-trial
#20
Thomas M Churilla, Karla V Ballman, Paul D Brown, Erin L Twohy, Kurt Jaeckle, Elana Farace, Jane H Cerhan, S Keith Anderson, Xiomara W Carrero, Yolanda I Garces, Fred G Barker, Richard Deming, Jesse G Dixon, Stuart H Burri, Caroline Chung, Cynthia Ménard, Volker W Stieber, Bruce E Pollock, Evanthia Galanis, Jan C Buckner, Anthony L Asher
PURPOSE: To determine whether whole-brain radiation therapy (WBRT) is associated with improved overall survival among non-small cell lung cancer (NSCLC) patients with favorable prognoses at diagnosis. METHODS AND MATERIALS: In the N0574 trial, patients with 1 to 3 brain metastases were randomized to receive stereotactic radiosurgery (SRS) or SRS plus WBRT (SRS + WBRT), with a primary endpoint of cognitive deterioration. We calculated diagnosis-specific graded prognostic assessment (DS-GPA) scores for NSCLC patients and evaluated overall survival according to receipt of WBRT and DS-GPA score using 2 separate cut-points (≥2...
August 5, 2017: International Journal of Radiation Oncology, Biology, Physics
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