keyword
https://read.qxmd.com/read/38493836/inhibition-of-lysyl-oxidase-by-pharmacological-intervention-and-genetic-manipulation-alleviates-epilepsy-associated-cognitive-disorder
#21
JOURNAL ARTICLE
Kang-Ni Chen, Qi-Lin Peng, Dan-Feng Cao, Zhao-Jun Wang, Kai Zhang, Xin-Yu Zhou, Dong-Yu Min, Bo-Ting Zhou, Xiao-Yuan Mao
Epilepsy-associated cognitive disorder (ECD), a prevalent comorbidity in epilepsy patients, has so far uncharacterized etiological origins. Our prior work revealed that lysyl oxidase (Lox) acted as a novel contributor of ferroptosis, a recently discovered cell death mode in the regulation of brain function. However, the role of Lox-mediated ferroptosis in ECD remains unknown. ECD mouse model was established 2 months later following a single injection of kainic acid (KA) for. After chronic treatment with KA, mice were treated with different doses (30mg/kg, 100mg/kg and 300mg/kg) of Lox inhibitor BAPN...
March 15, 2024: Brain Research Bulletin
https://read.qxmd.com/read/38487174/modification-of-4-4-chlorothiophen-2-yl-thiazol-2-amine-derivatives-for-the-treatment-of-analgesia-and-inflammation-synthesis-and-in-vitro-in-vivo-and-in-silico-studies
#22
JOURNAL ARTICLE
Mater H Mahnashi, Umer Rashid, Hassan Hussain Almasoudi, Mohammed H Nahari, Imran Ahmad, Abdulkarim S Binshaya, Osama Abdulaziz, Meshari A Alsuwat, Muhammad Saeed Jan, Abdul Sadiq
Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized seven new thiazole derivatives ( 5a - 5g ). Initially, we examined the in vitro anti-inflammatory potentials of our compounds using COX-1, COX-2, and 5-LOX enzyme assays. After in vitro confirmation, the potential compounds were subjected to in vivo analgesic and anti-inflammatory studies...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38487169/phenolic-phytochemistry-in-vitro-in-silico-in-vivo-and-mechanistic-anti-inflammatory-and-antioxidant-evaluations-of-habenaria-digitata
#23
JOURNAL ARTICLE
Hassan Hussain Almasoudi, Muhammad Saeed Jan, Mohammed H Nahari, Abdulfattah Yahya M Alhazmi, Abdulkarim S Binshaya, Osama Abdulaziz, Mater H Mahnashi, Muhammad Ibrar, Rehman Zafar, Abdul Sadiq
Excessive and imbalance of free radicals within the body lead to inflammation. The objective of the current research work was to explore the anti-inflammatory and antioxidant potential of the isolated compounds from Habenaria digitata. In this study, the isolated phenolic compounds were investigated for in vitro and in vivo anti-inflammatory potential along with the antioxidant enzyme. The anti-inflammatory and antioxidant potential of the phenolic compounds was assayed via various enzymes like COX-1/2, 5-LOX and ABTS, DPPH, and H2 O2 free radical enzyme inhibitory assay...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38484676/pro-inflammatory-enzyme-inhibition-of-lipoxygenases-by-flavonoid-rich-extract-from-artemisia-vulgaris
#24
JOURNAL ARTICLE
Jin Ru Lim, Lee Suan Chua, Azizul Azri Mustaffa
The peroxyl radicals generated by the activity of lipoxygenases (LOX) are mediators to trigger inflammatory diseases. Therefore, it is important to investigate potent LOX inhibitor for modulating the occurrence and resolving inflammatory processes. Artemisa vulgaris, is a herbal plant that is known for flavonoids, potentially inhibiting lipid peroxidation and scavenging radicals. The objectives of the present study were to obtain flavonoids rich extract from A. vulgaris, and determine the inhibitory mode of the extract against LOX...
March 10, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38483957/the-candidate-proteins-associated-with-keratoconus-a-meta-analysis-and-bioinformatic-analysis
#25
JOURNAL ARTICLE
Ting Song, Jie Song, Jingyi Li, Halima Ben Hilal, Xiaona Li, Pengfei Feng, Weiyi Chen
PURPOSE: Keratoconus (KC) is a multifactorial disorder. This study aimed to conduct a systematic meta-analysis to exclusively explore the candidate proteins associated with KC pathogenesis. METHODS: Relevant literature published in the last ten years in Pubmed, Web of Science, Cochrane, and Embase databases were searched. Protein expression data were presented as the standard mean difference (SMD) and 95% confidence intervals (CI). The meta-analysis is registered on PROSPERO, registration number CRD42022332442 and was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement (PRISMA)...
2024: PloS One
https://read.qxmd.com/read/38483920/reactive-oxygen-species-responsive-nanoparticles-toward-extracellular-matrix-normalization-for-pancreatic-fibrosis-regression
#26
JOURNAL ARTICLE
Liang Qi, Bo-Wen Duan, Hui Wang, Yan-Jun Liu, Han Han, Meng-Meng Han, Lei Xing, Hu-Lin Jiang, Stephen J Pandol, Ling Li
Pancreatic fibrosis (PF) is primarily characterized by aberrant production and degradation modes of extracellular matrix (ECM) components, resulting from the activation of pancreatic stellate cells (PSCs) and the pathological cross-linking of ECM mediated by lysyl oxidase (LOX) family members. The excessively deposited ECM increases matrix stiffness, and the over-accumulated reactive oxygen species (ROS) induces oxidative stress, which further stimulates the continuous activation of PSCs and advancing PF; challenging the strategy toward normalizing ECM homeostasis for the regression of PF...
March 14, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38475558/physiological-and-transcriptomic-analyses-reveal-the-mechanisms-underlying-methyl-jasmonate-induced-mannitol-stress-resistance-in-banana
#27
JOURNAL ARTICLE
Jiaxuan Yu, Lu Tang, Fei Qiao, Juhua Liu, Xinguo Li
Exogenous methyl jasmonate (MeJA) application has shown promising effects on plant defense under diverse abiotic stresses. However, the mechanisms underlying MeJA-induced stress resistance in bananas are unclear. Therefore, in this study, we treated banana plants with 100 μM MeJA before inducing osmotic stress using mannitol. Plant phenotype and antioxidant enzyme activity results demonstrated that MeJA improved osmotic stress resistance in banana plants. Thereafter, to explore the molecular mechanisms underlying MeJA-induced osmotic stress resistance in banana seedlings, we conducted high-throughput RNA sequencing (RNA-seq) using leaf and root samples of "Brazilian" banana seedlings treated with MeJA for 0 h and 8 h...
March 3, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38474215/gene-expression-studies-in-down-syndrome-what-do-they-tell-us-about-disease-phenotypes
#28
REVIEW
Laura R Chapman, Isabela V P Ramnarine, Dan Zemke, Arshad Majid, Simon M Bell
Down syndrome is a well-studied aneuploidy condition in humans, which is associated with various disease phenotypes including cardiovascular, neurological, haematological and immunological disease processes. This review paper aims to discuss the research conducted on gene expression studies during fetal development. A descriptive review was conducted, encompassing all papers published on the PubMed database between September 1960 and September 2022. We found that in amniotic fluid, certain genes such as COL6A1 and DSCR1 were found to be affected, resulting in phenotypical craniofacial changes...
March 4, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472175/the-hif-1%C3%AE-plod2-axis-integrates-extracellular-matrix-organization-and-cell-metabolism-leading-to-aberrant-musculoskeletal-repair
#29
JOURNAL ARTICLE
Heeseog Kang, Amy L Strong, Yuxiao Sun, Lei Guo, Conan Juan, Alec C Bancroft, Ji Hae Choi, Chase A Pagani, Aysel A Fernandes, Michael Woodard, Juhoon Lee, Sowmya Ramesh, Aaron W James, David Hudson, Kevin N Dalby, Lin Xu, Robert J Tower, Benjamin Levi
While hypoxic signaling has been shown to play a role in many cellular processes, its role in metabolism-linked extracellular matrix (ECM) organization and downstream processes of cell fate after musculoskeletal injury remains to be determined. Heterotopic ossification (HO) is a debilitating condition where abnormal bone formation occurs within extra-skeletal tissues. Hypoxia and hypoxia-inducible factor 1α (HIF-1α) activation have been shown to promote HO. However, the underlying molecular mechanisms by which the HIF-1α pathway in mesenchymal progenitor cells (MPCs) contributes to pathologic bone formation remain to be elucidated...
March 12, 2024: Bone Research
https://read.qxmd.com/read/38471004/enzyme-mediated-bioorthogonal-cascade-catalytic-reaction-for-metabolism-intervention-and-enhanced-ferroptosis-on-neuroblastoma
#30
JOURNAL ARTICLE
Qi Wang, Xiangze Li, Zhiyao Cao, Wei Feng, Yu Chen, Dapeng Jiang
It remains a tremendous challenge to explore effective therapeutic modalities against neuroblastoma, a lethal cancer of the sympathetic nervous system with poor prognosis and disappointing treatment outcomes. Considering the limitations of conventional treatment modalities and the intrinsic vulnerability of neuroblastoma, we herein develop a pioneering sequential catalytic therapeutic system that utilizes lactate oxidase (LOx)/horseradish peroxidase (HRP)-loaded amorphous zinc metal-organic framework, named LOx/HRP-aZIF, in combination with a 3-indole-acetic acid (IAA) prodrug...
March 12, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38469407/efficacy-of-polyethylene-glycol-loxenatide-for-type-2-diabetes-mellitus-patients-a-systematic-review-and-meta-analysis
#31
JOURNAL ARTICLE
Yibo Liu, Wenjing Ma, Hui Fu, Zhe Zhang, Yanyan Yin, Yongchun Wang, Wei Liu, Shaohong Yu, Zhongwen Zhang
Objective: Some studies have proved that polyethylene glycol loxenatide (PEG-Loxe) has significant effects on controlling blood glucose and body weight in patients with type 2 diabetes mellitus (T2DM), but there is still some controversy over the improvement of blood lipid profiles (BLP) and blood pressure (BP), and more evidences are needed to verify such effects. Therefore, this study was conducted to provide a comprehensive evaluation of the efficacy of PEG-Loxe in improving blood glucose (BG), BLP, BP, body mass index (BMI), and body weight (BW) in patients with T2DM for clinical reference...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38468823/identification-of-lysyl-oxidase-as-an-adipocyte-secreted-mediator-that-promotes-a-partial-mesenchymal-to-epithelial-transition-in-mda-mb-231-cells
#32
JOURNAL ARTICLE
Cassidy M Van Stiphout, Grant Kelly, Nikitha K Pallegar, Eman Elbakry, Ana Valeria Vilchis-Celis, Sherri L Christian, Alicia M Viloria-Petit
AIM: Breast cancer (BC) is the most common cancer in women worldwide, where adiposity has been linked to BC morbidity. In general, obese premenopausal women diagnosed with triple-negative BC (TNBC) tend to have larger tumours with more metastases, particularly to the bone marrow, and worse prognosis. Previous work using a 3-dimensional (3D) co-culture system consisting of TNBC cells, adipocytes and the laminin-rich extracellular matrix (ECM) trademarked as Matrigel, demonstrated that adipocytes and adipocyte-derived conditioned media (CM) caused a partial mesenchymal-to-epithelial transition (MET)...
2024: Exploration of targeted anti-tumor therapy
https://read.qxmd.com/read/38466882/crosstalk-of-lysyl-oxidase-like-1-and-lysyl-oxidase-prolongs-their-half-lives-and-regulates-liver-fibrosis-through-notch-signal
#33
JOURNAL ARTICLE
Ning Zhang, Aiting Yang, Wen Zhang, Hong Li, Anjian Xu, Xuzhen Yan, Qi Han, Bingqiong Wang, Hong You, Wei Chen
BACKGROUND: Lysyl oxidase (LOX) family members (LOX and LOXL1 to 4) are crucial copper-dependent enzymes responsible for cross-linking collagen and elastin. Previous studies have revealed that LOX and LOXL1 are the most dramatically dysregulated LOX isoforms during liver fibrosis. However, the crosstalk between them and the underlying mechanisms involved in the profibrotic behaviors of HSCs, as well as the progression of liver fibrosis, remain unclear. METHODS: pCol9GFP-HS4,5Tg mice, Loxl1fl/flGfapCre mice, human HSC line, and primary HSCs were enrolled to study the dysregulation pattern, profibrotic roles, and the potential mechanisms of LOX and LOXL1 interaction involved in the myofibroblast-like transition of HSCs and liver fibrogenesis...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38466162/rapid-screening-and-isolation-of-5-lipoxygenase-inhibitors-in-inonotus-obliquus-and-mechanism-of-action-in-the-treatment-of-asthma
#34
JOURNAL ARTICLE
Haocheng Yun, Zhen Liu, Wanchao Hou, Qiang Liu, Yuyu Nong, Sainan Li, Chunming Liu
Accurate screening and targeted preparative isolation of active substances in natural medicines have long been two technical challenges in natural medicine research. This study outlines a new approach to improve the efficiency of natural product preparation, focusing on rapidly and accurately screening potential active ingredients in Inonotus obliquus as well as efficiently preparing 5-lipoxidase (5-LOX) inhibitors, to provide new ideas for the treatment of asthma with Inonotus obliquus. First, we used ultrafiltration (UF) mass spectrometry to screen for three potential inhibitors of 5-LOX in Inonotus obliquus...
March 2024: Journal of Separation Science
https://read.qxmd.com/read/38464309/coordination-between-cytoskeletal-organization-cell-contraction-and-extracellular-matrix-development-is-depended-on-lox-for-aneurysm-prevention
#35
Rohtem Aviram, Shelly Zaffryar-Eilot, Anna Kaganovsky, Anas Odeh, Shay Melamed, Ruslana Militsin, Cameron B Pinnock, Ariel Shemesh, Raz Palty, Santhi K Ganesh, Peleg Hasson
Distinct, seemingly independent, cellular pathways affecting intracellular machineries or extracellular matrix (ECM) deposition and organization, have been implicated in aneurysm formation. One of the key genes associated with the pathology in both humans and mice is Lysyl oxidase (LOX), a secreted ECM-modifying enzyme, highly expressed in medial vascular smooth muscle cells. To dissect the mechanisms leading to aneurysm development, we conditionally deleted Lox in smooth muscle cells. We find that cytoskeletal organization is lost following Lox deletion...
February 29, 2024: bioRxiv
https://read.qxmd.com/read/38462455/dicarbonyl-modified-low-density-lipoproteins-are-key-inducers-of-lox-1-and-nox1-gene-expression-in-the-cultured-human-umbilical-vein-endotheliocytes
#36
JOURNAL ARTICLE
Vadim Z Lankin, Mars G Sharapov, Alla K Tikhaze, Ruslan G Goncharov, Olga A Antonova, Galina G Konovalova, Vladimir I Novoselov
Expression of LOX-1 and NOX1 genes in the human umbilical vein endotheliocytes (HUVECs) cultured in the presence of low-density lipoproteins (LDL) modified with various natural dicarbonyls was investigated for the first time. It was found that among the investigated dicarbonyl-modified LDLs (malondialdehyde (MDA)-modified LDLs, glyoxal-modified LDLs, and methylglyoxal-modified LDLs), the MDA-modified LDLs caused the greatest induction of the LOX-1 and NOX1 genes, as well as of the genes of antioxidant enzymes and genes of proapoptotic factors in HUVECs...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38461237/strategies-for-labelling-of-exogenous-and-endogenous-extracellular-vesicles-and-their-application-for-in-vitro-and-in-vivo-functional-studies
#37
REVIEW
Marie Boudna, Andres Delgado Campos, Petra Vychytilova-Faltejskova, Tana Machackova, Ondrej Slaby, Kamila Souckova
This review presents a comprehensive overview of labelling strategies for endogenous and exogenous extracellular vesicles, that can be utilised both in vitro and in vivo. It covers a broad spectrum of approaches, including fluorescent and bioluminescent labelling, and provides an analysis of their applications, strengths, and limitations. Furthermore, this article presents techniques that use radioactive tracers and contrast agents with the ability to track EVs both spatially and temporally. Emphasis is also placed on endogenous labelling mechanisms, represented by Cre-lox and CRISPR-Cas systems, which are powerful and flexible tools for real-time EV monitoring or tracking their fate in target cells...
March 9, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38453127/lxa4-protected-mice-from-renal-ischemia-reperfusion-injury-by-promoting-irg1-nrf2-and-irak-m-traf6-signal-pathways
#38
JOURNAL ARTICLE
Hongtao Tie, Ge Kuang, Xia Gong, Lidan Zhang, Zizuo Zhao, Shengwang Wu, Wenya Huang, Xiahong Chen, Yinglin Yuan, Zhenhan Li, Hongzhong Li, Li Zhang, Jingyuan Wan, Bin Wang
Excessive inflammatory response and increased oxidative stress play an essential role in the pathophysiology of ischemia/reperfusion (I/R)-induced acute kidney injury (IRI-AKI). Emerging evidence suggests that lipoxin A4 (LXA4), as an endogenous negative regulator in inflammation, can ameliorate several I/R injuries. However, the mechanisms and effects of LXA4 on IRI-AKI remain unknown. In this study, A bilateral renal I/R mouse model was used to evaluate the role of LXA4 in wild-type, IRG1 knockout, and IRAK-M knockout mice...
March 5, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38445291/atherosclerosis-and-toll-like-receptor4-tlr4-lectin-like-oxidized-low-density-lipoprotein-1-lox-1-and-proprotein-convertase-subtilisin-kexin-type9-pcsk9
#39
REVIEW
Bahador Bagheri, Zahra Khatibiyan Feyzabadi, Ahmad Nouri, Ali Azadfallah, Mahyar Mahdizade Ari, Maral Hemmati, Mahboubeh Darban, Parisa Alavi Toosi, Seyedeh Zahra Banihashemian
Atherosclerosis is a leading cause of death in the world. A significant body of evidence suggests that inflammation and various players are implicated and have pivotal roles in the formation of atherosclerotic plaques. Toll-like receptor 4 (TLR4) is linked with different stages of atherosclerosis. This receptor is highly expressed in the endothelial cells (ECs) and atherosclerotic plaques. TLR4 activation can lead to the production of inflammatory cytokines and related responses. Lectin-like oxidized low-density lipoprotein-1 (LOX-1), an integral membrane glycoprotein with widespread expression on the ECs, is involved in atherosclerosis and has some common pathways with TLR4 in atherosclerotic lesions...
2024: Mediators of Inflammation
https://read.qxmd.com/read/38442806/hawthorn-leaf-flavonoids-alleviate-the-deterioration-of-atherosclerosis-by-inhibiting-scap-srebp2-ldlr-pathway-through-spla2-%C3%A2-a-signaling-in-macrophages-in-mice
#40
JOURNAL ARTICLE
Xufeng Bai, Shuwen Wang, Limei Shu, Qingyu Cao, Huiming Hu, Yanchen Zhu, Chen Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Hawthorn leaves are a combination of the dried leaves of the Rosaceae plants, i.e., Crataegus pinnatifida Bge. or Crataegus pinnatifida Bge. var. major N. E. Br., is primarily cultivated in East Asia, North America, and Europe. hawthorn leaf flavonoids (HLF) are the main part of extraction. The HLF have demonstrated potential in preventing hypertension, inflammation, hyperlipidemia, and atherosclerosis. However, the potential pharmacological mechanism behind its anti-atherosclerotic effect has yet to be explored...
March 3, 2024: Journal of Ethnopharmacology
keyword
keyword
8770
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.